Claims
- 1. A protein capable of stimulating superoxide production, wherein the protein comprises mox or duox, a fragment thereof or a conservative substitution thereof.
- 2. The protein of claim 1, wherein the protein comprises the amino acid sequence of SEQ ID NO:2, a fragment thereof, or a conservative substitution thereof.
- 3. The protein of claim 1, wherein the protein comprises the amino acid sequence of SEQ ID NO:4, a fragment thereof, or a conservative substitution thereof.
- 4. The protein of claim 1, wherein the protein comprises the amino acid sequence of SEQ ID NO:21, a fragment thereof, or a conservative substitution thereof.
- 5. The protein of claim 1, wherein the protein comprises the amino acid sequence of SEQ ID NO:42, a fragment thereof, or a conservative substitution thereof.
- 6. The protein of claim 1, wherein the protein comprises the amino acid sequence of SEQ ID NO:46, a fragment thereof, or a conservative substitution thereof.
- 7. The protein of claim 1, wherein the protein comprises the amino acid sequence of SEQ ID NO:48, a fragment thereof, or a conservative substitution thereof.
- 8. A nucleotide sequence encoding for the protein, the fragment thereof or the conservative substitution thereof as recited in claim 1.
- 9. The nucleotide sequence of claim 8, wherein the nucleotide sequence comprises SEQ ID NO:1, a fragment thereof, or a conservative substitution thereof.
- 10. The nucleotide sequence of claim 8, wherein the nucleotide sequence comprises SEQ ID NO:3, a fragment thereof, or a conservative substitution thereof.
- 11. The nucleotide sequence of claim 8, wherein the nucleotide sequence comprises SEQ ID NO:22, a fragment thereof, or a conservative substitution thereof.
- 12. The nucleotide sequence of claim 8, wherein the nucleotide sequence comprises SEQ ID NO:41, a fragment thereof, or a conservative substitution thereof.
- 13. The nucleotide sequence of claim 8, wherein the nucleotide sequence comprises SEQ ID NO:45, a fragment thereof, or a conservative substitution thereof.
- 14. The nucleotide sequence of claim 8, wherein the nucleotide sequence comprises SEQ ID NO:47, a fragment thereof, or a conservative substitution thereof.
- 15. A vector, wherein the vector comprises a nucleotide sequence encoding for the protein, the fragment thereof or the conservative substitution thereof, as recited in claim 1.
- 16. The vector of claim 15 wherein the nucleotide sequence comprises SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:22, SEQ ID NO:41, SEQ ID NO:45, or SEQ ID NO:47, a fragment thereof, or a conservative substitution thereof.
- 17. A cell containing the vector of claim 15.
- 18. A cell containing the vector of claim 16.
- 19. An antibody, wherein the antibody is capable of binding to the protein, the fragment thereof, or the conservative substitution thereof, as recited in claim 1.
- 20. The antibody of claim 19, wherein the protein, the fragment thereof, or the conservative substitution thereof, has the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:21, SEQ ID NO:42, SEQ ID NO:46, or SEQ ID NO:48, a fragment thereof, or a conservative substitution thereof.
- 21. A method of stimulating superoxide formation comprising administration, in vitro or in vivo, of a composition comprising the protein, the fragment thereof, or the conservative substitution thereof of claim 1 in a pharmaceutically acceptable carrier.
- 22. The method of claim 21, wherein the protein, the fragment thereof, or the conservative substitution thereof comprises the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:21, SEQ ID NO:42, SEQ ID NO:46, or SEQ ID NO:48, a fragment thereof, or a conservative substitution thereof.
- 23. A method of stimulating superoxide formation comprising administration, in vitro or in vivo, of a composition comprising the vector of claim 15 in a pharmaceutically acceptable carrier.
- 24. A method of stimulating superoxide formation comprising administration, in vitro or in vivo, of a composition comprising the vector of claim 16 in a pharmaceutically acceptable carrier.
- 25. A method for determining the activity of a drug comprising measuring the activity of the protein, the fragment thereof or the conservative substitution thereof, as recited in claim 1, to stimulate superoxide production following administration of the drug.
- 26. The method of claim 25, wherein the protein, the fragment thereof or the conservative substitution thereof comprises the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:21, SEQ ID NO:42, SEQ ID NO:46, or SEQ ID NO:48, a fragment thereof, or a conservative substitution thereof.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Patent Application Serial No. 60/107,911, filed Nov. 10, 1998, U.S. Provisional Patent Application Serial No. 60/149,332, filed Aug. 17, 1999, and U.S. Provisional Patent Application Serial No. 60/151,242, filed Aug. 27, 1999. Each of the aforementioned patent applications is hereby incorporated by reference in its entirety.
Government Interests
[0002] The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of National Institutes of Health grants HL38206 and HL58000.
Provisional Applications (3)
|
Number |
Date |
Country |
|
60107911 |
Nov 1998 |
US |
|
60149332 |
Aug 1999 |
US |
|
60151242 |
Aug 1999 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09437568 |
Nov 1999 |
US |
Child |
10318906 |
Dec 2002 |
US |