Claims
- 1. A multimeric antiviral agent comprising two units wherein said units may be the same or different and are each independently selected from the group consisting of transmembrane intercellular adhesion molecule-1 (tmICAM-1) and truncated forms of intercellular adhesion molecule-1 (tICAMs), each of said units containing at least one unpaired cysteine residue at a position selected from the group consisting of 307 and 309, wherein each of said units is linked to at least one other of said units via a disulfide bridge, and wherein said multimeric antiviral agent binds to HRV and reduces infectivity thereof.
- 2. A multimeric antiviral agent according to claim 1 wherein said tICAM is selected from the group consisting of tICAM(453) and tICAM(185).
- 3. The multimeric antiviral agent of claim 1 which is dimeric tmICAM-1 wherein each monomer of tmICAM-1 contains a cysteine residue at position 307 and said cysteine residues form a disulfide bridge.
- 4. The multimeric antiviral agent of claim 1 which is dimeric tmICAM-1 wherein each monomer of tmICAM-1 contains a cysteine residue at position 309 and said cysteine residues form a disulfide bridge.
- 5. The multimeric antiviral agent of claim 1 which is dimeric tICAM(453) wherein each monomer of tICAM(453) contains a cysteine residue at position 307 and said cysteine residues form a disulfide bridge.
- 6. The multimeric antiviral agent of claim 1 which is dimeric tICAM(453) wherein each monomer of tICAM(453) contains a cysteine residue at position 309 and said cysteine residues form a disulfide bridge.
Parent Case Info
This is a continuation of copending U.S. application Ser. No. 08/318,038, filed 4 Oct. 1994, which is a continuation of U.S. Ser. No. 08/171,261, filed 21 Dec. 1993, abandoned, which is a continuation of U.S. Ser. No. 07/977,590, filed 17 Nov. 1992, abandoned, which is a continuation of U.S. Ser. No. 07/704,984, filed 24 May 1991, abandoned, which is a continuation-in-part of U.S. Ser. No. 07/556,238, filed 20 Jul. 1990, abandoned.
US Referenced Citations (13)
Foreign Referenced Citations (1)
Number |
Date |
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A-1463088 |
Oct 1988 |
AUX |
Continuations (4)
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318038 |
Oct 1994 |
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171261 |
Dec 1993 |
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977590 |
Nov 1992 |
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704984 |
May 1991 |
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Continuation in Parts (1)
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556238 |
Jul 1990 |
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