Claims
- 1. A multimeric antiviral agent comprising two or more tICAMs having the ability to bind to HRV of the major receptor class, wherein said tICAMs are multimerized by binding to an antibody that does not interfere with said HRV binding, and wherein said multimeric antiviral agent mimics the multimeric configuration of tmICAM-1 and exhibits enhanced binding to said HRV relative to the constituent monomers.
- 2. The multimeric antiviral agent of claim 1 wherein said multimer is a dimer.
- 3. The multimeric antiviral agent of claim 1 wherein said antibody is selected from the group consisting of CL 203 and antibodies which bind to the same epitope as CL 203.
- 4. The multimeric antiviral agent according to claim 3 wherein said antibody is CL 203.
- 5. The multimeric antiviral agent according to claim 1 wherein at least one of said tICAMs is tICAM(453).
- 6. The multimeric antiviral agent of claim 5 wherein all of said tICAMs are tICAM(453).
- 7. In a method for enhancing the binding of a tICAM to HRV of the major receptor class, the improvement comprising presenting said tICAM to said HRV in the form of a multimeric antiviral agent according to claim 1, 2, 3, 4, 5, or 6.
- 8. A method for reducing infectivity of a human rhinovirus of the major receptor class, said method comprising contacting said virus with a multimeric antiviral agent according to claim 1, 2, 3, 4, 5, or 6.
- 9. A pharmaceutical composition comprising a pharmaceutically acceptable solvent, diluent, adjuvant or carrier and a multimeric antiviral agent according to claim 1, 2, 3, 4, 5, or 6.
Parent Case Info
This is a continuation of copending application USSN 08/318,038, filed Oct. 4, 1994, which is a continuation of USSN 08/171,261, filed Dec. 21, 1993, abandoned, which is a continuation of USSN 07/977,590, filed Nov. 17, 1992, abandoned, which is a continuation of USSN 07/704,984, filed May 24, 1991, abandoned, which is a continuation-in-part of USSN 07/556,238, filed Jul. 20, 1990, abandoned.
US Referenced Citations (14)
Foreign Referenced Citations (1)
Number |
Date |
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A-1463088 |
Oct 1988 |
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Continuations (4)
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318038 |
Oct 1994 |
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171261 |
Dec 1993 |
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977590 |
Nov 1992 |
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704984 |
May 1991 |
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Continuation in Parts (1)
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556238 |
Jul 1990 |
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