Claims
- 1. An improved multiple wavelength light spectrophotometer for non-invasive monitoring of a body organ in vivo comprising:
- (a) a single light source emitting radiation at at least four near infrared wavelengths including a lamp powered by AC-timed pulses;
- (b) an optical fiber transmitting the near infrared radiation emitted from said single light source to a body organ;
- (c) an optical fiber receiving near infrared radiation transmitted through the organ by said transmitting optical fiber (b) and conducting the received infrared radiation to a radiation detector (d), which receiving optical fiber is disposed in relation to said transmitting optical fiber (b) so that the two optical fibers are aligned or form an angle therebetween of up to 180.degree.;
- (d) a radiation detector having means for branching the radiation conducted from optical fiber (c) into at least four different wavelengths, comprising a system of at least four interference filters and complimentary photomultipliers whereby at least four individual signals corresponding to said at least four different wavelengths are produced and transmitted to amplifier means (e);
- (e) amplifier means for converting said at least four individual signals to continuous signals; and
- (f) data acquisition means connected to said amplifier means for converting the continuous signals into display signals representing values of physiological parameters, including a microprocessor utilizing the following algorithm to correct the display signals for light diffusion effects:
- .delta.OD.sub.app (.lambda.)=(C.sub.2 .lambda.-2C.sub.3 .lambda.A)(a.sub.1 .lambda..delta.V+a.sub.2 .lambda..delta.O+a.sub.3 .lambda..delta.R)+A.gamma.(C.sub.2o .lambda.-AC.sub.3o .lambda.).delta.S,
- wherein
- OD.sub.app is the apparent optical density at a given wavelength (.lambda.);
- A is absorbance;
- S is the blood volume;
- R is the redox state of cyt aa.sub.3 ;
- O is the hemoglobin oxygen saturation; and
- V is the heme value.
- 2. An improved multiple wavelength light spectrophotometer as claimed in claim 1 wherein the light source is a xenon flash lamp.
- 3. An improved multiple wavelength light spectrophotometer as claimed in claim 1 wherein the interference filters have a mid-height bandwidth within the range of 4 to 25 nm centered in the 700 to 950 nm range.
- 4. An improved multiple wavelength light spectrophotometer as claimed in claim 3 wherein the interference filters have a mid-height within the range of 4 to 25 nm centered at 750, 800, 850 and 900 nm, respectively.
- 5. An improved multiple wavelength light spectrophotometer as claimed in claim 3 wherein the interference filters have a mid-height bandwidth within the range of 4 to 25 nm centered at 750, 820, 850 and 900 nm, respectively.
- 6. An improved multiple wavelength light spectrophotometer for non-invasive monitoring of a body organ in vivo comprising:
- (a) a single light source emitting radiation at at least four near infrared wavelengths including a lamp powered by AC-timed pulses;
- (b) an optical fiber transmitting the near infrared radiation emitted from said single light source to a body organ;
- (c) an optical fiber receiving near infrared radiation transmitted through the organ by said transmitting optical fiber (b) and conducting the received infrared radiation to a radiation detector (d), which receiving optical fiber is disposed in relation to said transmitting optical fiber (b) so that the two optical fibers are aligned or form an angle therebetween of up to 180.degree.;
- (d) a radiation detector having means for branching the radiation conducted from optical fiber (c) into at least four different wavelengths, comprising a system of a single interference filter variable in the range of 750 to 900 nm and complimentary photomultiplier whereby at least four individual signals corresponding to said at least four different wavelengths are produced and transmitted to amplifier means (e);
- (e) amplifier means for converting said at least four individual signals to continuous signals; and
- (f) data acquisition means connected to said amplifier means for converting the continuous signals into display signals representing values of physiological parameters, including a microprocessor utilizing the following algorithm to correct the display signals for light diffusion effects:
- .delta.OD.sub.app (.lambda.)=(C.sub.2 .lambda.-2C.sub.3 .lambda.A)(a.sub.1 .lambda..delta.V+a.sub.2 .lambda..delta.O+a.sub.3 .lambda..delta.R)+A.gamma.(C.sub.2o .lambda.-AC.sub.3o .lambda.).delta.S,
- wherein
- OD.sub.app is the apparent optical density at a given wavelength (.lambda.);
- A is absorbance;
- S is the blood volume;
- R is the redox state of cyt aa.sub.3 ;
- O is the hemoglobin oxygen saturation; and
- V is the heme value.
Priority Claims (1)
Number |
Date |
Country |
Kind |
22247 A/84 |
Aug 1984 |
ITX |
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Parent Case Info
This application is a continuation-in-part of application Ser. No. 06/756,394, filed July 17, 1985, now abandoned.
US Referenced Citations (12)
Non-Patent Literature Citations (1)
Entry |
Takatani et al., 30th ACEMB, Los Angeles, 5-9 Nov. 1977, p. 171. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
756394 |
Jul 1985 |
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