Nebulizer

Description

BACKGROUND

The present invention relates to a nebulizer for nebulizing a fluid.

WO 2006/125577 A2 discloses a nebulizer which comprises, as a reservoir for fluid which is to be atomized or nebulized, an insertable rigid container having an inner bag containing the fluid and a pressure generator with a drive spring for delivering and atomizing the fluid. The container is pre-installed in nebulizer in a delivery state. The pre-installed container is held by a transportation lock unmovable within the housing in the delivery state in order to avoid any undesired opening of the container. Before being used for the first time a lower housing part of the nebulizer is completely closed. Thus, the pre-installed container is opened by a delivery tube piercing a sealing and a septum to fluidically connect to the inner bag of the container. Further, the transportation lock is opened so that the container can move inside the nebulizer back and forth.

By rotating the lower housing part the drive spring can be put under tension and fluid can be sucked into a compression chamber of the pressure generator. Simultaneously, the container is moved into the lower housing part in a stroke movement within the nebulizer and when tensioned for the first time the container may be pierced through its base by a piercing element in the lower housing part to allow venting of the container. After manual operation of a stop element the drive spring is released and moves the delivery tube into the pressure chamber so that the fluid is put under pressure by the drive spring and is delivered or atomized through a nozzle into a mouthpiece as an aerosol, without the use of propellant gas.

WO 2007/022898 A2, US 2011/0011393 A1, and WO 2012/162305 A1 disclose a similar nebulizer. A container can be inserted into a housing of the nebulizer. The housing is closed by a lower housing part. The container is moving axially forth and back during conveying of the fluid to be nebulized, and during pressure generation and nebulization. A counter device can be arranged in the lower housing part. The counter device locks the nebulizer against further use if a predetermined number of operations has been reached or exceeded. Then, the housing part may be replaced together with the counter device and the container. The container may be connected inseparably with the housing part. Further, the nebulizer comprises a device for permanently locking the nebulizer when a certain number of containers have been used or when a certain number of operations have been reached.

SUMMARY

Object of the present invention is to provide a nebulizer allowing easy and/or improved handling and/or secure or defined indication of handling and state.

According to one aspect of the present invention, the nebulizer comprises preferably a blocking device which is adapted to block opening of the housing, when the nebulizer or, in particular, its energy store is in a tensioned state (In this tensioned state, the nebulizer is in a loaded state, i.e. in a ready-to-discharge state, in particular in a state in which a dose of fluid is dispensed or discharged upon the actuation of a stop element). Preferably, the housing can only be opened if the nebulizer is in an untensioned state or discharged state. This allows or ensures secure handling and/or a defined position of the preferably moveable container when opening the nebulizer and/or replacing the container.

According to another aspect of the present invention, the nebulizer comprises preferably a blocking device, preferably the blocking device mentioned above, adapted to block indexing (i.e. the step-wise movement) of an indicator member, when the nebulizer or its energy store is in a tensioned state. This allows or ensures easy and/or improved handling and/or secure or defined indication of handling and state, in particular when the indicator member shows a required container replacement only when the nebulizer or its energy store is not in a tensioned state, i.e. preferably after relaxing the energy store or a drive spring of the nebulizer.

Preferably, the indicator member shows numbers and/or symbols, in particular indicating any required steps such as container replacement, closing of the housing, or the like.

Preferably, the blocking device controls blocking of opening of the housing by means of the indicator member, in particular by blocking required indexing of the indicator member.

Preferably, the blocking device blocks indexing of the indicator member in the tensioned state. The indicator member, in turn, blocks preferably opening of the housing in the tensioned state. Thus, the blocking device preferably indirectly (in particular by means of the indicator member and/or control member) controls or blocks opening of the housing and/or locks the nebulizer or housing part selectively against opening.

Preferably, the nebulizer comprises a counter device for counting pressurizing and/or dispensing operations of the nebulizer and a guidance device which comprises the indicator member and/or control member. In particular, an actuation part of the counter device cooperates with the guidance device when a predetermined number of pressurizing and/or dispensing operations have been reached or exceeded with the current container. Thus, the guidance device can indicate a required container replacement and/or enable the opening of the housing when a container has to be replaced.

The control of opening of the nebulizer via the indicator member allows a simple integration of the blocking device and/or results in a well defined indication of the necessary steps to a user and/or allows a secure handling for the user.

According to a further aspect of the present invention, the nebulizer comprises preferably an indicator device for indicating a tensioned state of the nebulizer or its energy store. This allows visualization of the status (tensioned or not tensioned) and facilitates handling of the nebulizer.

According to another aspect of the present invention, the nebulizer comprises preferably a manually depressable actuator member at a housing part, wherein the housing part is detachable together with the actuator member from the housing of the nebulizer for replacing the container when the actuator member is depressed. This facilitates the handling in particular because the user can detach the housing part together with the still depressed actuator member from the nebulizer and does not have to leave the actuator member at the nebulizer.

Preferably, the actuator member is or forms a push button. This allows very easy and intuitive manual actuation.

The actuator member or push button acts preferably on a retaining element arranged on or at the nebulizer non-detachable. Thus, the housing part is detached from the retaining elements as well when the housing part is detached from the nebulizer.

The retaining element forms preferably a catch or snap for preferably automatically holding or securing the housing part when it is shifted onto or into the nebulizer, most preferably with two catch positions, i.e. a first catch position with partly closed housing part or housing of the nebulizer and a second catch position with completely closed housing part or housing.

Preferably, the retaining element is blocked against release when the blocking device or indicator member blocks release of the retaining element. In particular, the blocking device or indicator member may block the retaining element against depression and, thus, against release (in this case, the retaining element cannot be depressed and, thus, the actuator member or push button can neither be depressed), in particular when a predetermined number of doses of fluid have not yet been dispensed from the current container, the nebulizer is still tensioned and/or a further container replacement is not allowed.

The above aspects of the present invention and the further aspect described below can be realized independently from each other, and in any combination.

DESCRIPTION OF THE DRAWINGS

Further advantages, features, characteristics and aspects of the present invention will become apparent from the claims and the following description of a preferred embodiment with reference to the drawings. It shows:

FIG. 1 a schematic section of a known nebulizer in a non-tensioned state;

FIG. 2 a schematic section, rotated 90° compared with FIG. 1, of the known nebulizer in a tensioned state;

FIG. 3 a schematic section of a nebulizer in a delivery state with a partly closed housing and with a pre-installed, closed container;

FIG. 4 a schematic section of the nebulizer according to FIG. 3 in an activated, tensioned state with completely closed housing and with opened container;

FIG. 5 a schematic section of the nebulizer according to FIG. 4 in a non-tensioned state;

FIG. 6 a schematic perspective view of a nebulizer according to the present invention with a separate housing part shown with a partly cut-away portion, the housing part having a securing device holding unmoveably a container of the nebulizer;

FIG. 7 a schematic section of the nebulizer according to FIG. 6;

FIG. 8 a schematic side view of the nebulizer according to FIG. 6 with partly mounted housing part and with some cut-away portions, the container being held unmoveably;

FIG. 9 a schematic section of the nebulizer according to FIG. 6 in the completely closed state with opened securing device so that the container can move axially;

FIG. 10 a schematic section of the housing part with the associated container after use or separation from the nebulizer;

FIG. 11 a perspective view of an upper part of the nebulizer according to FIG. 6 without the housing part and with partly cut-away portions;

FIG. 12 a side view of a control/indicator member of the nebulizer according to FIG. 6;

FIG. 13 a perspective view of the control/indicator member according to FIG. 12;

FIG. 14 a perspective side view of a lock member of the nebulizer according to FIG. 6;

FIG. 15 another perspective view of the lock member according to FIG. 14;

FIG. 16 a partial schematic section of the nebulizer with a blocking device according to the present invention;

FIG. 17 a partial axial section of the area of FIG. 16 showing the blocking of an indicator member or control member by the blocking device;

FIG. 18 a perspective view of the blocking device;

FIG. 19 another perspective view of the blocking device;

FIG. 20 a schematic section of an upper part of the nebulizer with an indicator device according to the present invention in a first position;

FIG. 21 a schematic section similar to FIG. 20 with the indicator device in a second position;

FIG. 22 a schematic section of the nebulizer according to the present invention with detached housing part comprising a depressable actuator member;

FIG. 23 a schematic section of the nebulizer according to FIG. 22 with partly attached housing part;

FIG. 24 a schematic section of the nebulizer according to FIG. 22 with completely attached housing part or completely housing; and

FIG. 25 a partial enlarged view of the encircled area of FIG. 24.

DETAILED DESCRIPTION

In the Figures, the same reference numerals are used for identical or similar parts, resulting preferably in corresponding or comparable properties and advantages, even if the associated description is not repeated.

FIGS. 1 and 2 show a known nebulizer 1 for atomizing a fluid 2, particularly a highly effective pharmaceutical composition, medicament or the like, diagrammatically shown in a non-tensioned state (FIG. 1) and in a tensioned state (FIG. 2). The nebulizer 1 is constructed in particular as a portable inhaler and preferably operates only mechanical and/or without propellant gas.

When the fluid 2, preferably a liquid, more particularly a pharmaceutical composition, is nebulized, an aerosol 14 (FIG. 1) is formed, which can be breathed in or inhaled by a user. Usually the inhaling is done at least once a day, more particularly several times a day, preferably at set intervals, depending on the complaint or illness from which a patient is suffering.

The nebulizer 1 is provided with or comprises an insertable or replaceable container 3 containing the fluid 2. The container 3 thus forms a reservoir for the fluid 2, which is to be nebulized. Preferably, the container 3 contains multiple doses of fluid 2 or active substance in particular sufficient to provide up to 200 dosage units or doses, for example, i.e. to allow up to 200 sprays or applications. A typical container 3, as disclosed in WO 96/06011 A1, holds e.g. a volume of about 2 to 20 ml.

It has to be noted that the dose can vary, in particular depending on the fluid 2 or medicament. The nebulizer 1 can be adapted respectively.

Further, the number of doses contained in the container 3 and/or the total volume of the fluid 2 contained in the container 3 can vary depending on the fluid 2 or respective medicament and/or depending on the container 3 and/or depending on the necessary medication or the like.

Preferably, the container 3 can be replaced or exchanged, wherein the number of containers 3, which can be used with the same nebulizer 1, is preferably restricted, e.g. to a total number of four or five containers 3.

The container 3 is preferably substantially cylindrical or cartridge-shaped and once the nebulizer 1 has been opened the container 3 can be inserted therein preferably from below and changed if desired. It is preferably of rigid construction, the fluid 2 in particular being held in a collapsible bag 4 in the container 3. In particular, the container 3 comprises a venting hole 31 which is opened before or during first use.

The nebulizer 1 comprises a delivery mechanism, preferably a pressure generator 5, for conveying and nebulizing the fluid 2, particularly in a preset and optionally in an adjustable dosage amount. The nebulizer or pressure generator 5 comprises preferably a holder 6 for releasably holding the container 3, a drive spring 7 associated to the holder 6, only partly shown, and/or a stop element 8 preferably in form of or with a button for preferably manual actuation or depressing, which stop element 8 can catch and block the holder 6 and can be manually operated to release the holder 6 allowing drive spring 7 to expand. The nebulizer 1 or pressure generator 5 comprises preferably further a conveying element, such as a conveying tube 9, a non-return valve 10, a pressure chamber 11 and/or a nozzle 12 for nebulizing the fluid 2 into a mouthpiece 13. The completely inserted container 3 is fixed or held in the nebulizer 1 via the holder 6 such that the conveying tube 9 penetrates into the container 3. The holder 6 is preferably constructed so that the container 3 can be exchanged.

When the drive spring 7 is axially tensioned in the tensioning process the holder 6 with the container 3 and the conveying tube 9 are moved downwards in the drawings and fluid 2 is sucked out of the container 3 into the pressure chamber 11 of the pressure generator 5 through the non-return valve 10. In this state, the holder 6 is caught by the stop element 8 so that the drive spring 7 is kept compressed. Then, the nebulizer 1 is in the so-called loaded or tensioned state.

During the subsequent relaxation in the nebulization process after actuation or pressing of the stop element 8 the fluid 2 in the pressure chamber 11 is put under pressure as the conveying tube 9 with its now closed non-return valve 10 is moved back in the pressure chamber 11, here in the drawings upwards, by the relaxation or force of the drive spring 7 and now acts as a pressing ram or piston. This pressure forces the fluid 2 through the nozzle 12, whereupon it is nebulized into the aerosol 14, as shown in FIG. 1.

Generally, the nebulizer 1 operates with a spring pressure of 5 to 200 MPa, preferably 10 to 100 MPa on the fluid 2, and/or with a volume of fluid 2 delivered per stroke of 10 to 50 μl, preferably 10 to 20 μl, most preferably about 15 μl. The fluid 2 is converted into or nebulized as aerosol 14, the droplets of which have an aerodynamic diameter of up to 20 μm, preferably 3 to 10 μm. Preferably, the generated jet spray has an angle of 20° to 160°, preferably 80° to 100°. These values also apply to the nebulizer 1 according to the teaching of the present invention as particularly preferred values.

A user or patient (not shown) can inhale the aerosol 14, preferably while an air supply can be sucked into the mouthpiece 13 through at least one optional air supply opening 15.

Preferably, the drive spring 7 can be manually activated or tensioned (or the nebulizer 1 can be loaded), in particular by actuation of an actuation member.

The nebulizer 1 comprises preferably a housing or (upper) housing part 16 and optionally a biasing or inner part 17 preferably which is rotatable relative thereto (FIG. 2) and/or having an upper part 17a and a lower part 17b (FIG. 1).

The nebulizer 1 comprises preferably an in particular manually operable (lower) housing part or cap 18 releasable fixed, particularly fitted or held onto the inner part 17, preferably by means of a retaining element 19.

Preferably, the housing parts 16 and 18 and/or other parts form a housing of the nebulizer 1. In order to insert and/or replace the container 3, preferably the housing can be opened and/or the housing part 18 can be detached from the nebulizer 1 or its housing. Generally and preferably, the container 3 can be inserted before the housing is closed and/or before the housing part 18 is connected to the housing. Preferably, the container 3 is inserted, opened and/or fluidically connected to the delivery mechanism automatically or simultaneously when (completely) connecting the housing part 18 to the housing/nebulizer 1 and/or when (completely) closing the housing/nebulizer 1.

The actuation member, preferably the housing part 18, can be actuated, here rotated relative to the upper housing part 16, carrying with it or driving the inner part 17. As a result the drive spring 7 is tensioned in the axial direction by means of a gear or transmission (not shown) formed between the inner part 17, in particular its upper part 17a, and the holder 6 and acting on the holder 6. During tensioning the container 3 is moved axially downwards until the container 3 assumes an end position as shown in FIG. 2. In this activated or tensioned state the drive spring 7 is under tension and can be caught or held by the stop element 8. During the nebulizing process the container 3 is moved back into its original position (non-tensioned position or state shown in FIG. 1) by the drive spring 7. Thus the container 3 executes a lifting or stroke movement during the tensioning process and during the nebulizing process.

The housing part 18 preferably forms a cap-like lower housing part and fits around or over a lower free end portion of the container 3. As the drive spring 7 is tensioned the container 3 moves with its end portion (further) into the housing part 18 or towards the end face thereof, while an aeration means, such as an axially acting spring 20 arranged in the housing part 18, comes in contact with base 21 of the container 3 and pierces the container 3 or a base seal thereon with a piercing element 22 when the container 3 makes contact with it for the first time, to allow air in or aeration.

The nebulizer 1 comprises preferably a counter device 23, which counts in particular actuations of the nebulizer 1, preferably by detecting its tensioning or the rotation of the inner part 17 relative to the upper part 16 or housing. Preferably, the counter device 23 or an associated lock locks the (further) actuation or use of the nebulizer 1, e.g. blocks further rotation of the housing part 18/inner part 17 and, thus, tensioning of the nebulizer 1 or its drive spring 7 and/or blocks actuation of the stop element 8, when a certain number of actuations or operations or discharged doses has been reached or exceeded.

A preferred construction and mode of operation of the inhaler or nebulizer 1 will now be described in more detail with reference to FIGS. 3 to 5, but emphasizing only essential differences from the nebulizer 1 according to FIGS. 1 and 2. The remarks relating to FIGS. 1 and 2 thus apply preferably accordingly or in a similar manner, while any desired combinations of features of the nebulizer 1 according to FIGS. 1 and 2 and the nebulizer 1 described below are possible.

Preferably, the container 3 is pre-installed. This can be realized in particular as shown in WO 2006/125577 A2 or as described in the following.

FIG. 3 shows the nebulizer 1 in a delivery state with preferably pre-installed container 3, which is still closed. In this state, the housing of the nebulizer 1 is not completely closed, in particular the housing part 18 is not completely pushed on the inner part 17. FIGS. 4 and 5 show the nebulizer 1 in an activated state with the housing completely closed and with the container 3 opened. In FIG. 4, the nebulizer 1 or drive spring 7 is tensioned, i.e. the container 3 is in its lower position. FIG. 5 shows the nebulizer 1 in a non-tensioned state, e.g. after dispensing or nebulizing of one dose of the fluid 2; the container 3 is in its upper position.

The container 3 comprises a fluid outlet 24 for outputting the fluid 2 to be dispensed. In particular, the fluid outlet 24 allows a fluidic connection between the container 3 or its bag 4 on one hand and the nebulizer 1, its pressure generator 5 or the conveying element on the other hand.

The fluid outlet 24 has an inner closure 25 that is preferably formed by a septum, a membrane, a plastic seal or the like and/or is provided inside the container 3. Optionally, a second or outer closure 26 can be provided such that successive opening is possible by means of one common element, in particular the conveying element or conveying tube 9 or the like, and/or by piercing.

Preferably, the first or inner closure 25 is formed or supported by a closure part 27 extending from the outlet or head end of the container 3 into the container 3 or bag 4. The second or outer closure 26 is preferably located adjacent to the head or axial end of the container 3 and/or held or connected to a flange 28, which can be formed by the closure part 27 or any other suitable part. However, other constructional solutions are possible.

In the delivery state according to FIG. 3, the container 3 has been pre-installed, i.e. inserted into the nebulizer 1. However, the container 3 or its fluid outlet 24 is not yet opened. In particular, the second closure 26 is already opened, but not the first closure 25. This is achieved in particular in that the housing of the nebulizer 1 is closed only partly, i.e. not completely, in the delivery state.

In particular, the container 3 is attached to or held by or secured in the housing part 18, in particular by a transportation lock 29, which is preferably arranged within or at the housing part 18. The transportation lock 29 holds the container 3 preferably temporarily, in particular before attaching the housing part 18 to the nebulizer 1 and/or in the delivery state. In particular, the transportation lock 29 holds the container 3 fixed during the fluidic connection of container 3 and/or during the mechanic connection of container 3, here with holder 6. Preferably, the transportation lock 29 holds the container 3 fixed during opening, in particular piercing, the container 3.

In the delivery state, in which the nebulizer 1 can be shipped or delivered to the user or is still packed, the nebulizer 1 or the housing part 18 is preferably secured, in particular by means of a securing member 30, e.g. a banderole, such that the container 3 and/or housing part 18 are held sufficiently spaced from the nebulizer 1 or upper housing part 16 and/or prevented from being completely closed or completely inserted or pushed on the conveying element or tube 9, the housing or inner housing part 17 or the like and/or such that (complete) opening of the container 3, namely of the first closure 25, is prevented.

Once the security member 30 has been removed a user (not shown) can push the housing part 18 fully on in the axial direction and thereby open the container 3, i.e. first closure 25, by inserting the conveying element or conveying tube 9. FIGS. 4 and 5 show this activated state with the housing part 18 pushed fully on and/or the container 3 open (fluidically connected to the nebulizer 1 or its pressure generator 5 or the conveying element or tube 9).

FIG. 4 shows the nebulizer 1 or container 3 in the activated state, the container 3, i.e. first closure 25, is open, i.e. the container 3 or its fluid 2 is fluidically connected to the nebulizer 1 or its pressure generator 5, and the housing part 18 has been pushed fully on in the axial direction. In order to bring the holder 6 into (complete) engagement with the container 3 at the head end and then be able to move the container 3 back and/or forth for the suction/tensioning and pressing strokes, it may be necessary to tension the nebulizer 1 or it drive spring 7 for the first time. During this tensioning process the holder 6 is moved together with the conveying tube 9 axially towards or into the housing part 18, thus bringing the holder 6 into (complete) engagement with the container 3 and preferably also moving or pressing the container 3 against the piercing element 22 in the region of the base of the housing part 18 and thereby piercing or opening a venting hole 31 in the container base 21. FIG. 4 shows the nebulizer 1 in this tensioned and activated state. The holder 6 is engaged with the container 3 and the conveying tube 9 has been fully inserted into the container 3.

FIG. 5 shows the nebulizer 1 in the relaxed, non-tensioned state, i.e. after atomization or discharge of a dose of the fluid 2. The holder 6 and the container 3 are in the upper position. The holder 6 is still engaged with the container 3 and remains engaged during the further uses of the nebulizer 1. Further, the container 3 is still open and fluidically connected, i.e. the nebulizer 1 remains activated.

To prevent unwanted opening of the container 3, particularly of the first closure 25, in the delivery state of the nebulizer 1, and/or to prevent (axial) movement of the container 3 relative to the associated housing part 18 before complete closing of the nebulizer 1, preferably the transportation lock 29 is provided. By frictional, forcible or interlocking engagement, for example, the transportation lock 29 prevents the container 3 from undesirably moving axially.

Preferably, the opening of the transportation lock 29 occurs automatically when closing the nebulizer 1 or its housing completely, i.e. when snapping or pushing on the housing part 18 completely towards the upper housing part 16. During this (preferably linear, axial or telescopic) closing movement, the transportation lock 29 is opened and the container 3 released in axial direction preferably during or after piercing or opening the container 3 and/or preferably during only a last part of the movement and/or just little before the final completely closed position is reached or just when the final completely closed position is reached.

During the closing movement in which preferably parts 17 and 18 are joined, the transportation lock 29 is preferably opened by the direct or indirect interaction with or actuation by the housing of the nebulizer 1, the inner part 17 or its lower part 17b or the like. Preferably, the container 3 and/or first closure 25 are opened as well as the transportation lock 29 by means of a common actuation and/or component, here the closing movement of the nebulizer 1 or its housing or bottom part 18.

FIGS. 4 and 5 show the transportation lock 29 in the open position, i.e. wherein the container 3 is free to move axially.

In the following, a preferred embodiment of the nebulizer 1 according to the present invention will be described in more detail with reference to the further Figures, wherein only essential differences from the nebulizer 1 described above or shown in FIGS. 1 to 5 will be emphasized or described. Thus, the remarks relating to FIGS. 1 to 5 apply preferably accordingly or in a similar manner, while any desired combinations of features are possible.

FIG. 6 shows the nebulizer 1 in a perspective side view with not yet mounted, i.e. separated (lower) housing part 18 (partly cut open for illustration purposes) with associated container 3. The container 3 has not been inserted or pre-installed in the nebulizer 1 yet. With other words, the nebulizer 1 has not been assembled yet or is not in the preferred delivery state yet.

FIG. 7 shows the nebulizer 1 in a schematic section as well as the container 3 and housing part 18 which are still separated from the (upper part of the) nebulizer 1.

The nebulizer 1 or its housing or housing part 18 comprises preferably a securing device 32 which may have different functions. The securing device 32 may hold the container 3 such that the container 3 is moveable back and forth within the completely closed housing for conveying the fluid 2, pressure generation and/or nebulization, wherein the securing device 32 may ensure that the container 3 is inseparable from the housing or housing part 18. Thus, only complete replacement of the housing part 18 together with the respective container 3 is possible. Alternatively or additionally, the securing device 32 may form the transportation lock 29. Alternatively or additionally, the securing device 32 may prevent that the used container 3 and/or used housing part 18 can be (re)connected to or used with the nebulizer 1 once more.

When the securing device 32 or transportation lock 29 is closed, the container 3 is held or counter-beared for opening by inserting the conveying element or tube 9, preferably wherein a press-fit is formed between the conveying element or tube 9 and the container 3 or closure part 27, and/or for (completely) connecting the container (head) to the holder 6. With other words, the transportation lock 29 or securing device 32 form preferably a counter-bearing for the container 3 during closing of the nebulizer 1.

When the securing device 32 or transportation lock 29 is closed, the container 3 is held spaced from the piercing element 22.

The securing device 32 is preferably located or arranged or fixed at or in the housing part 18 as shown in FIGS. 6 and 7.

Preferably, the securing device 32 comprises or consists of a metal and/or stamped part and/or consists of a single, unitary part. The securing device 32 may consist of two or more parts, preferably connected by means of gluing, crimping, riveting, welding, or the like.

Preferably, the securing device 32 is made of steel, in particular spring steel. Preferably, the securing device 32 is produced from sheet material by cutting, stamping or the like and/or by bending. Preferably, the securing device 32 or a part thereof forms a cage, in particular encompassing the container 3 or an end portion thereof, in particular the container base 21.

Preferably, the securing device 32 comprises holding elements 33 and/or locking elements 34. The elements 33 and/or 34 are preferably designed like arms, fingers, leaves or the like. In particular, the elements 33 and 34 are alternately distributed over the circumference of the container 3. Preferably, the securing device 32 comprises multiple holding elements 33 and multiple locking elements 34, in particular three or more holding elements 33 and three or more locking elements 34. Preferably, the elements 33 and 34 extend at least essentially axially and/or in the direction of the back and forth movement of the container 3 and/or in the direction of the longitudinal or main extension of the nebulizer 1 or main dispensing direction of the aerosol 14.

Preferably, the elements 33 and 34 are held by or connected with a base 35 of the securing device 32, as shown in FIG. 8. FIG. 8 shows the nebulizer 1 in a schematic side view with already partly mounted housing part 18 and with some cut-away portions. The transportation lock 29 or securing device 32 is still closed or locked, i.e. the container 3 is still securely held so that it cannot axially move (axially means in the direction of the back and forth or stroke movements).

Preferably, the securing device 32 or base 35 comprises or holds the piercing element 22 for piercing the container 3, i.e. opening the container base 21 or its venting hole 31 or a respective sealing of the container 3 or the like in the activated and tensioned state, i.e. when the container 3 reaches its lower end position. In the shown and preferred embodiment, the piercing element 22 is formed by a respective bending of a spring portion 36 of the securing device 32 or its base 35. The spring portion 36 can support or facilitate the (complete or final) connection of the container 3 to the holder 6.

The securing device 32 or base 35 comprises preferably at least one or multiple fixing portions 37 for fixing the securing device 32 at or in the nebulizer 1 or housing or housing part 18. In particular, the fixing portions 37 may fix the securing device 32 when it is pressed into the housing part 18 by cooperating with the sidewall of the housing part 18. However, it is also possible to overmold the securing device 32, its base 35, the fixing portions 37 or the like. Moreover, the securing device 32 could be connected with the housing part 18 or the like in any other suitable manner, in particular, by a separate fixing member, by gluing or the like.

As already mentioned, the securing device 32 preferably forms the transportation lock 29 for holding the container 3 unmovable in the housing or housing part 18 in the delivery state of the nebulizer and/or before attaching the housing part 18 to the nebulizer 1. In this situation (in particular in the delivery state), the container 3 or a preferably radially protruding and/or circumferentially extending part or edge 38 thereof, preferably formed at the container base 21, is held preferably in a form-fit manner and/or between the holding elements 33 and locking elements 34, in particular between respectively formed or bent end portions 33a and 34a of the elements 33 and 34, respectively, as shown in FIGS. 6 to 8.

In the shown embodiment, the container 3 and/or edge 38 is caught between the end portions 33a and 34a, preferably alternatively. The holding elements 33 and/or end portions 33a grip or extend over the edge 38, and the locking elements 34 or its end portions 34a grip or extend under the edge 38, so that the edge 38 and container 3 are securely held in between, in particular by form-fit, preventing any axial movement of the container 3 relative to the securing device 32 and relative to the associated housing part 18 in this state or delivery state, i.e. with locked transportation lock 29/securing device 32.

Preferably, the end portions 33a and/or 34a are formed like claws or the like and/or extend preferably radially inwardly.

Preferably, the elements 33 and/or 34 can flex with its free ends radially outwardly.

Preferably, the securing device 32 is designed such that the associated container 3 can be connected with the securing device 32 by a respective axial force or movement, wherein the elements 33 and/or 34 flex preferably automatically outwardly as required to receive the container 3 in the locked position as shown in FIGS. 6 to 8. However, if necessary, a suitable tool (not shown) or the like could be used alternatively or additionally for assembly if necessary.

For example, the ends of the end portions 33a could be inclined such that the container 3 may be inserted into or connected with the securing device 32 by a respective axial movement so that the holding elements 33 flex outwardly to allow passing of edge 38.

Preferably, the holding elements 33 or its end portions 33a prevent separation of the container 3 from the securing device 32 and, thus, from the associated housing part 18 or the like.

In the present embodiment, the holding elements 33 extend preferably above the end portions 33a and/or form or comprise preferably arm-like guiding and/or locking portions 33b. These axial extensions and/or these portions 33b extend axially beyond the end portions 33a and/or may cooperate with the container 3 or its edge 38 during axial assembly of the container 3 with the securing device 32 such that the holding elements 33 are flexed sufficiently outwardly so that the edge 38 can pass the end portions 33a and the container base 21 can be seated on the end portions 34a of the locking elements 34.

The locking elements 34 preferably comprise actuation portions 34b at its free ends extending axially beyond the end portions 34a. The actuation portions 34b may radially guide the container 3 and/or facilitate insertion of the container 3 or its edge 38 between the free ends of the locking elements 34 although the locking elements 34 are preferably radially inwardly biased as well as the holding elements 33.

When, the container 3 is held with its edge 38 between the end portions 33a and 34a, the transportation lock 29/securing device 32 is closed, i.e. the container 3 cannot move axially within the housing part 18 or nebulizer 1.

For opening the transportation lock 29 or securing device 32, the locking elements 34 and/or its end portions 34a are flexed preferably radially outwardly so that the container 3 can freely move axially, in particular restricted such that the edge 38 can only move axially within the securing device 32 and/or that the axial movement is restricted (in the drawings upwardly) by the holding elements 33 or its end portions 33b and/or such that the container 3 cannot be separated from the securing device 32. This opening of the transportation lock 29 or securing device 32 will take place when activating the nebulizer 1, when using the nebulizer 1 for the first time and/or when completely closing the nebulizer 1. Then, the container 3 can axially move, in particular back and forth and/or with its edge 38 between the end portions 33a and the piercing element 22 in the present embodiment. This situation is schematically shown in the schematic section according to FIG. 9 which shows the nebulization with closed housing or housing part 18 and with opened transportation lock 29/securing device 32.

In FIG. 9, the container 3 is shown in its lower position similar to FIG. 4, in particular, wherein the container base 21 is in contact with the piercing element 32. However, the nebulizer 1 is not shown in the tensioned state, i.e. the holder 6 is not in its lower position, i.e. the holder 6 is not yet connected with the upper end or head of the container 3. Normally, the holder 6 would be connected to the container 3 in this situation with the container 3 in the lower position. With other words, usually the nebulizer 1 or drive spring 7 would be tensioned in the situation with the container 3 being in the lower position.

Preferably, the container is finally or completely or correctly connected to holder 6 when tensioning the nebulizer 1 or its drive spring 7 for the first time after completely closing the nebulizer 1. However, it is generally also possible that the nebulizer 1 is in the tensioned state, i.e. the drive spring 7 is already tensioned and the holder 6 is in the lower position, before or during (first) assembly with lower housing part 18. Consequently, the holder 6 should directly connect with the container 3 when completely closing the housing part 18, and the situation shown in FIG. 9 should normally not occur.

In FIG. 9, the end portions 34a are moved radially outwardly in order to open the transportation lock 29 or securing device 32. This is achieved preferably by flexing the locking elements 34 radially outwardly. This can be achieved in particular by acting on the actuation portions 34b.

Preferably, the transportation lock 29 is opened or the locking elements 34 are flexed outwardly when completely closing the nebulizer 1 or its housing part 18, in particular by cooperation with or abutment of the inner part 17, its lower part 17b, a retaining part 39 and/or a securing part 40. The retaining part 39 is preferably arranged at the upper housing part 16 or inner part 17. The securing part 40 is preferably arranged in the lower housing part 18.

The retaining part 39 is connected to the lower or free end of the inner part 17 or its lower part 17b in order to hold, bear or support an end (the lower end) of the drive spring 7. FIGS. 3 to 5 show a preferred construction of the retaining part 39. It is preferably formed as a ring and/or provided with hooks or the like for interconnection with the inner part 17. In the preferred embodiment, the retaining element 19 forms a unitary component or portion of the retaining part 39. However, other constructional solutions are possible.

In the embodiment shown in FIGS. 3 to 5, a preferably ring-like securing part 40 opens the transportation lock 29, in particular flexible arms of the transportation lock 29, to allow axial movement of the container 3. This securing part 40 keeps the transportation lock 29 or its flexible arms open when the nebulizer 1 or its housing part 18 has been completely closed. The securing part 40 is pushed axially downwards by abutment of the inner part 17 or retaining part 39 within the housing part 18 when completely closing the nebulizer 1.

In the preferred embodiment shown in FIGS. 6 to 15 and particular in FIG. 9, the nebulizer 1, housing part 18 or securing device 32 comprises the preferably ring-like securing part 40 for opening the transportation lock 29/securing device 32 or its locking elements 34. In particular, the securing part 40 is pushed axially downwards when closing the nebulizer 1 so that it is moved between the locking elements 34 or its actuation portions 34b and exerts an axial force radially outwards. Preferably, an inclined plane converts the axial or closing movement into an opening or radial movement which forces the actuation portions 34b radially outwardly when the securing part 40 is forced axially downwardly, here by abutment of the retaining part 39, in particular in the axial end position shown in FIG. 9.

Preferably, the securing part 40 and/or locking elements 34 or actuation portions 34b comprise a respectively inclined guiding surface 41 or the like to convert the axial closing movement or movement of the securing part 40 into the desired radial opening movement of the locking elements 34 or actuation portions 34b and, thus, of the end portions 34a to open the transportation lock 29, in particular when the housing has been completely closed or when the housing part 18 has been pushed completely on the nebulizer 1.

However, other constructional solutions are possible to realize opening of the transportation lock 29 or securing device 32 or its locking elements 34 or end portions 34a when closing the nebulizer 1 or its housing parts 18.

In the preferred embodiment the securing part 40 serves alternatively or additionally another purpose. Namely, the securing part 40 prevents the locking portions 33b from moving radially apart or flexing radially outwards before the nebulizer 1 is assembled with its housing part 18 for the first time.

As already mentioned, the securing device 32 prevents preferably that a container 3 can be connected to or used with the nebulizer 1 once more. In particular, the securing device 32 can prevent that a used housing part 18 or used container 3 can be reconnected to the nebulizer 1 once it has been detached from the nebulizer 1. Thus, the securing device 32 prevents any undesired reuse of the container 3 and/or housing part 18 with its preferably inseparable container 3.

In the present embodiment, the undesired reuse is prevented in that the locking portions 33b force apart or move apart or radially and/or outwards at least after the used container 3 and/or housing part 18 has been detached from the nebulizer 1 such that the used container 3 and/or housing part 18 cannot be connected to or used with the nebulizer 1 once more. Preferably, the locking portions 33b are biased such that the locking portions 33b force apart or move radially and/or outwards after release.

In the preferred embodiment, the locking portions 33b are held together or held against moving apart, radially and/or outwards by the securing part 40 (schematically indicated in FIG. 7) before the container 3 and the associated housing part 18 have been connected to the nebulizer 1 for the first time. In this pre-assembly state, the securing part 40 is located preferably near the free ends of the locking portions 33b and/or it encompasses that locking portions 33b such that locking portions 33b are held sufficiently close together to be inserted with its free ends within the retaining part 39 and/or drive spring 7 when pushing the housing part 18 axially onto the nebulizer 1 or its inner part 17, in particular lower part 17b.

The securing part 40 may cooperate with the locking portions 33b or protrusions 33c thereof (shown in FIG. 9) preferably such that the securing part 40 is held by a preferably radial engagement and/or frictional force in its (upper) position holding the locking portions 33b or holding elements 33 together in the pre-assembly state. Later during assembly, in particular during complete closing of the housing or pushing on the housing part 18, the locking portions 33b are moved into the retaining part 39 and drive spring 7, while the securing part 40 is moved axially downwards or towards the securing device 32, the container base 21 and/or bottom part of the end of the housing part 18. Then, the end position or completely assembled position is reached as shown in FIG. 9. In this state, the radially biased locking portions 33b are held together by the drive spring 7 as the securing part 40 does not hold the locking portions 33b together any more.

Preferably, the securing part 40 has opened the transportation lock 29 or locking elements 34 in the last part of the closing movement or just when completely closing the nebulizer 1 as already mentioned.

The schematic section of FIG. 10 shows the housing part 18 together with its associated container 3 after it has been used and separated from the nebulizer 1. The securing part 40 remains preferably in its lower position. The transportation lock 29 is (still) open. The container 3 is shown in its upper position where it is held by the end portions 33a of the holding elements 33 when detaching the container 3 from the nebulizer 1, in particular from the holder 6 and the conveying element or tube 9.

FIG. 10 shows that the locking portions 33b have been forced apart, in particular due to its biasing or elastic force, here moved radially outwardly with its free ends in particular due to its preferably radial biasing or elastic force. This forced apart position of the locking portions 33b blocks reconnection of the container 3 and/or housing part 18 and/or securing device 32 with the nebulizer 1. Thus, the already used container 3 cannot be reused. Thus, misuse of the container 3 or nebulizer 1 can be prevented.

The securing part 40 may additionally secure the holding elements 33 or its end portions 33a against radial opening when the securing part 40 is in its lower position as shown in FIGS. 9 and 10. In this case, the securing part 40 contacts the holding elements 33 preferably on the outer side to prevent or restrict any outward flexing. Thus, the securing device 32 or its holding elements 33 or end portions 33a are secured against opening so that the container 3 or its edge 38 is securely held within the securing device 32 or the cage formed by the securing device 32 or holding elements 33.

In the preferred embodiment, the counter device 23 is arranged preferably at the housing part 18 as schematically shown in FIGS. 7 to 10.

The counter device 23 counts the actuations or operations of the nebulizer 1 or the discharged doses, preferably for the respective container 3.

Preferably, the counter device 23 counts actuations or operations by detecting the rotation of the inner part 17 relative to the upper part 16 of the housing. With other words, the counter device 23 may count the tensioning the nebulizer 1 or its drive spring 7. However, other constructional solutions are possible.

Preferably, the counter device 23 comprises a threaded spindle or shaft 42 with an associated, preferably unitary formed drive gear 43. The counter device 23 comprises preferably further a rider 44 associated to the threaded shaft 42 and cooperating with the threaded shaft 42 such that the rider 44 is axially moved along the threaded shaft 42 as the shaft 42 is rotated.

The threaded shaft 42 is rotatable beared preferably in the lower housing part 18 and/or extents preferably parallel to the axial or longitudinal direction of the nebulizer 1 and/or to the axial or stroke movement of the container 3.

The drive gear 43 is located preferably at an upper end of the threaded shaft 42 and/or housing part 18, in particular such that it can mesh with a preferably inner toothing 45 of the housing or upper housing part 16 of the nebulizer 1 in the assembled state, i.e. when the housing of the nebulizer 1 is completely closed, as schematically shown in FIG. 9.

The counter device 23 or its rider 44, in particular the axial position of the rider 44 along the threaded shaft 42, may show or indicate the number of operations, in particular of tensioning, actuations or doses, which have already been performed or used with the current container 3 or which can still be performed with the current container 3. This operation number can in particularly been shown by a pointer 46 and/or an associated scale or the like which are visible reasonable through a corresponding window or transparent part of the housing part 18. It has to be noted that the number has not be shown precisely. In particular, it may be sufficient that the counter device 23, the rider 44 or its pointer 46 give a rough indication of the number. For this purpose, it may be sufficient if the scale shows only different colored areas or regions roughly indicating said number. Further, it has to be noted that other constructional solutions are possible as well.

The counter device 23 works preferably mechanically. This allows a very simple and robust construction and a very secure operation.

The counter device 23 may control or provide preferably locking of the nebulizer 1, indicating any required container replacement and/or container counting. For this purpose, the monitoring 23 or the rider 44 comprises preferably an actuation part 47 as schematically shown in FIG. 8. The actuation part 47 is preferably ridge-like and/or extending in axial direction and/or towards the upper housing part 16 and/or upwards.

The counter device 23 is associated to the respective housing part 18 and, thus, preferably to only one container 3 and counts operations of the nebulizer 1 with the respective container 3, i.e. counts (only) the number of doses of fluid 2 removed or still removable from this container 3.

It has to be noted that the first container 3 may be pre-installed together with the associated housing part 18 in the delivery state. This pre-installment is optional. Preferably, further separate containers 3 are delivered together with the nebulizer 1, wherein each container 3 is inseparably connected with an associated housing part 18 and, thus, with an associated counter device 23. Preferably, the counter device 23 or threaded shaft 42 of each housing part 18 is designed or provided with inhibition or brake means, such that any undesired counting or rotation is prevented before the respective housing part 18 is mounted to the nebulizer 1.

The nebulizer 1 comprises preferably a device 48 for counting the number of containers 3 that have been used or still can be used with the nebulizer 1 and/or for indicating or displaying said container numbers and/or symbols indicating container replacement and/or end of use. This device 48 is preferably for monitoring and/or user guidance.

Preferably, said numbers and/or symbols are visible or shown through a transparent part or window 49 of the nebulizer 1, in particular located in the upper housing part 16 as schematically indicated in FIG. 6. In particular, said numbers and/or symbols are shown at a side face of the nebulizer 1. Other arrangements or constructional solutions are possible.

FIG. 11 shows the nebulizer 1 without lower housing part 18 and without container 3 in a schematic side view, wherein parts of the upper housing part 16 have been cut-away so that the monitoring or guidance device 48 of the nebulizer 1 is better visible.

The nebulizer 1 or device 48 comprises preferably a member 50 for indicating or displaying said container number, symbols, a status, and/or user instructions, e.g. relating to container replacement, and/or for controlling locking of the nebulizer 1. Thus, the member 50 is also called indicator member and/or control member. Preferably, both functions are achieved by the same or one single member 50. However, it is also possible that the indicator member and the control member are formed by separate parts or multiple parts. Preferably, the following description shall be understood in such a broad sense.

Preferably, the nebulizer 1 or device 48 comprises a spring 51 for driving or moving, in particular rotating, the member 50. This spring 51 is shown in FIGS. 7, 8, 9 and 11. Preferably, the member 50 is driven or rotated—in particular in multiple steps and/or from an initial (rotational) position to a final (rotational) position—only by spring force or by means of the spring 51.

The spring 51 is preferably a helical, sleeve-like, ring-like and/or torsional spring and/or a leg spring. It is preferably located coaxially with and/or adjacent to the driven member 50.

The spring 51 is preferably mounted in a biased state so that it applies a rotational force to the member 50. For this purpose, the spring 51 is supported with one end or leg at the nebulizer 1, in particular at the upper housing part 16, and engages with its other end or leg with member 50, e.g. by abutting a respective shoulder or bearing portion 67 (shown in FIGS. 12 and 13) of the member 50 or the like.

FIG. 12 shows a preferred embodiment of the member 50 in a schematic side view. FIG. 13 shows the member 50 in a perspective view.

The member 50 is preferably formed by a unitary and/or molded part. The member 50 is preferably at least essentially ring-like and forms or comprises a preferably closed ring.

The member 50 comprises or is provided with numbers 52 indicating said container number, and/or with said symbols 53 for user guidance, in particular for indicating container replacement and/or end of use of the nebulizer 1. Preferably, the numbers 52 and symbols 53 are shown and/or arranged on the member 50 such that one or more numbers 52 and one or more symbols 53 alternate. In particular, between preferably consecutive numbers 52 one or more symbols 53 are arranged and/or shown such that these symbols 53 indicate e.g. necessary container replacement, opening of the nebulizer 1, closing of the nebulizer 1 or the like. This may be communicated or indicated by respective arrows, colors, marks or the like as symbols 53. Further, the last symbol 53 may indicate end of use of the nebulizer 1 or complete locking of the nebulizer 1, e.g. by an “X” or the like. This symbol 53 may be shown for example when the allowable number of operations or actuations of the nebulizer 1 have been reached or exceeded of the last container 3 that may be used with or in the nebulizer 1, i.e. indicating total or final locking of the nebulizer 1. In the present embodiment, preferably a sequence of at least two different symbols 53 is shown between different or consecutive numbers 52. This sequence of symbols 53 comprises preferably a first symbol 53 (e.g. arrow downwards) indicating opening of the nebulizer 1 for container replacement and a second symbol 53 (e.g. arrow upwards) indicating closure of the nebulizer 1 for completing container replacement. However, it is also possible to show only one, potentially similar or identical symbol 53 between the different or consecutive numbers 52, such as one symbol 53 indicating container replacement. Preferably, only one special or end symbol 53, such as “X”, is shown at the end when the allowable number of operations or actuations of the nebulizer 1 has been reached or exceeded for the last container 3 and/or when the nebulizer 1 is finally blocked and/or when no further container 3 can be inserted.

The member 50 comprises preferably engagement or stop portions 54 which are preferably formed by radial protrusions or the like in the present embodiment. The stop positions 54 are used preferably to allow or realize a stepwise movement or rotation (indexing) of the member 50.

The member 50 comprises further preferably blocking portions 55 which extend preferably axially and/or cooperate with the retaining element 19 to selectively lock the nebulizer 1 or housing part 18 against opening, in particular by selectively blocking the retaining element 19 against depressing or radial inward movement.

The member 50 comprises preferably control portions 56 for controlling or driving an associated lock 57 of the nebulizer 1. The control portions 56 are formed preferably by protrusions or indentions or inclined guiding surfaces or the like which preferably extend radially and/or which are preferably formed on an outer circumference of the member 50 or its ring portion. However, other arrangements are possible as well.

The lock 57 is preferably formed by a locking member 58 or a portion 59 thereof, which is preferably tongue-like, leaf-like and/or flexible. FIG. 14 shows in a perspective view the locking member 58. FIG. 15 shows in other perspective view the locking member 58.

The locking member 58 is preferably made of metal and/or formed by plate material and/or a stamped part or the like. The locking member 58 is preferably ring-like and/or sleeve-like.

The portion 59 is preferably bent or indented or provided with such a form, in particular in radial direction and/or provided with a crimp, corrugation 60 or the like, for cooperating with the member 50 and/or at least one or more or all of the control portions 56, in particular such that depending on the rotational movement or position of the member 50 the portion 59 is radially flexed, in particular outwards, or not. For example, the control portions 56 are indented or recessed so that a portion 59 is not flexed radially outwards if the respective corrugation 60, which extends radially inwards from the respective portion 59, is received in a portion 56 located adjacent to this corrugation 60 on the inner side. If the member 50 is in another rotational portion, the corrugation 60 may abut on the non-recessed outer periphery of member 50 so that the respective portion 59 is flexed outwards and the lock 57 is closed. Thus, the lock 57 is driven or controlled, namely closed and opened, by means of the control member 50, in particular depending on its rotational position.

As already mentioned, the device 48 or member 50 is preferably driven by spring force, in the present embodiment by the force of spring 51. In particular, the member 50 is rotated or indexed stepwise by means of the force of the spring 51, wherein a ratchet or stop mechanism is provided to ensure the only stepwise moving or rotating of the member 50. In particular, stop means engage with the stop portions 54 of the member 50. In the present embodiment, the mechanism or stop means are preferably formed by one or two stop elements 61. The stop elements 61 are preferably formed like arms and/or by the locking member 58. The stop elements 61 are preferably elastically flexible to selectively allow a stop portion 54 to pass, i.e. to selectively allow the member 50 to index one step further, or to block a stop portion 54 and, thus, member 50 against further rotation. Preferably, the stop elements 61 are biased into a stopping position such that each stop element 61 extends into the way of movement of the stop portions 24 such that no stop portion 54 can pass the respective stop element 61.

Preferably, at least two stop elements 61 are provided and preferably offset such that stop elements 61 can be actuated alternatively to allow the member 50 to index or move further by one step, i.e. by one rotational movement or increment when the stop elements 61 are alternatively actuated, e.g. flexed, in particular in axial and/or radial direction, to allow one stop portion 54 to pass. The stop elements 61 are preferably flexed upwards to allow the respective stop portion 54 to pass. The actuation of the stop elements 61 will be explained in more detail below.

The stop elements 61 or its free ends may be provided with a broadened abutment or engagement body or surface, in particular by respectively bending the element or arm 61, by overmolding or the like. Each stop element 61 may be provided with a contact element 61a as schematically shown in FIG. 8. The contact element 61a may be formed by overmolding and/or may be shoe-like. The contact element 61a may form a stop or abutment for the stop portions 54 such that the member 50 is blocked against further rotation by force of spring 51 when the stop element 61 or contact element 61a is in the blocking position, here in the lower position shown in FIG. 8 where one stop portion 54 abuts the contact element 61a and cannot pass in circumferential direction. Here, the stop element 61 or contact element 61a has to be moved upwards or axially so that the blocked stop portion 51 can pass and the member 50 can index one step further in circumferential direction.

In the following, the operation and handling of the nebulizer 1 will be explained in more detail.

The nebulizer 1 may be delivered with a pre-installed container 3 and pre-attached housing part 18. In this case, the nebulizer 1 or its housing part 18 is not completely closed so that the container 3 is not yet fluidically connected or opened.

Alternatively the nebulizer 1 may be delivered with a separate container 3 and housing part 18. In this case the container 3 and the housing part 18 are preferably pre-assembled, i.e. form a unit that is separate from the nebulizer 1.

In any case, the nebulizer 1 is preferably delivered together with multiple containers 3, e.g. four or five containers 3, wherein each container 3 is inseparably connected to an associated housing part 18. These units of containers 3 and housing parts 18 can be exchanged so that the nebulizer 1 can be used with multiple containers 3 one after the other.

In both cases, the container 3 is preferably held unmoveably at or within the housing part 18 by the closed transportation lock 29 or securing device 39.

In both cases, the housing part 18 comprises preferably a coding, e.g. by one or more grooves, protrusions, ribs 62 or the like distributed around the inner circumference of the housing part 18 and/or axially extending, as schematically indicated in FIG. 10. This coding corresponds to the container 3 or the respective fluid 2 associated to the housing part 18. The coding matches to a complementary coding at the nebulizer 1, in particular at the inner part 17 or retaining part 39, and is preferably formed by respectively arranged and/or dimensioned indentions, coding portions 63, such as protrusion, indentions, recesses or the like, in particular formed by or at the retaining ring or part 39, as schematically shown in FIG. 11. Only when the codings match, the housing part 18 and, thus, the container 3 can be pre-installed and/or (completely) connected to or with the nebulizer 1.

Before (completely) closing the nebulizer 1 or its housing part 18, the device 48 or indicator member 50 may indicate by a respective symbol 53, such as an arrow pointing upwards, to completely close the nebulizer 1 or housing part 18.

When the housing part 18 is completely closed, the container 3 associated to the housing part 18 is fluidically connected to the nebulizer 1. This is detected or registered by the nebulizer 1 or device 48. This detection of the connection of the housing part 18 and, thus, of an associated container 3 is preferably realized mechanically, in particular by actuating one of the stop elements 61 to allow the member 50 to index one step further, i.e. until the other stop element 61 stops further indexing or rotation of the member 50. In the present embodiment, this registration or actuation is preferably achieved by a protrusion 64 formed at the housing part 18, in particular at its upper front face, as shown in particular in FIG. 7. When completely closing nebulizer 1, the protrusion 64 abuts one associated stop element 61 or contact element 61a and consequently flexes the stop element 61 or contact element 61a upwards such that it does not stop a corresponding stop portion 54 of the member 50 anymore, but allows the member 50 to move or rotate one step further, i.e. until the other stop element 61, which has not been flexed out of engagement in this state, stops further rotation by stopping a corresponding stop portion 54, preferably another one of stop portions 54.

As already mentioned, the container 3 is preferably inseparable from the housing part 18, the associated counter device 23 and/or associated securing device 32. Thus, after connection of a new container 3 with the nebulizer 1, the associated counter device 23 starts counting of the number of operations or uses of the respective container 3 that have already been performed or still can be performed. This operation number may be indicated or shown by the counter device 23 or its rider 44 or pointer 46 as already mentioned, while the device 48 or member 50 preferably only shows the container number 52, i.e. the number of containers 3 that have already been used or still can be used with the nebulizer 1.

Preferably, the nebulizer 1 is blocked against opening until the current container 3 has been (sufficiently) emptied, and/or until a predetermined number of operations or actuations has been reached or exceeded. This blocking of the nebulizer 1 or its housing part 18 against opening and/or container replacement is preferably achieved by a respective blocking portion 55 of the member 50 located below the retaining element 19 in this state as schematically indicated e.g. in FIG. 9, such that the retaining element 19 cannot be depressed, i.e. the nebulizer 1 cannot be opened and the housing part 18 cannot be detached.

When a predetermined number of operations or actuations of the nebulizer 1 has been reached, the nebulizer 1 is blocked against further use with the current container 3. This blocking is also called first locked state.

The first locked state is entered preferably by means of the counter device 23. In particular, the rider 44 or its actuation part 47 cooperate with the device 48 to enter the first locked state, when a predetermined number of operations have been reached or exceeded with the current container 3. Particularly, the rider 44 or its actuation part 47 reach an upper axial position in this state and actuate a respective stop element 61 or contact element 61a that is in blocking position or engagement with a stop portion 54. Thus, the stop element 61 or contact element 61a is preferably flexed or deformed such that the previously stopped stop portion 54 can pass and the member 50 is free to index one step further by the force of spring 51. FIG. 8 shows a situation, in which the rider 44 and actuation part 47 are already near the upper position and near the position to actuate the associated stop element 61 or contact element 61a. However, in the state shown in FIG. 8 one stop portion 54 and the member 50 are still blocked against rotating one step further.

The above indexing of the member 50 by one step leads to the first locked state. In this state, the nebulizer 1 or retaining element 19 is unblocked so that it can be opened. In particular, the blocking portion 55 blocking actuation of the retaining element 19 in the previous state is moved further, so that the retaining element 19 is not blocked any more, but can be actuated or pushed in order to allow detachment of the housing part 18 for container replacement.

In the first locked state the nebulizer 1, device 48 or member 50 indicates preferably by a respective symbol 53, in particular by an arrow pointing downwards, that container replacement is necessary and/or that the nebulizer 1 is locked against further use with the current container 3.

By the above indexing of the member 50 to reach the first locked state, the nebulizer 1 is locked against further use. This is achieved in particular in that the member 50 drives the lock 57 to lock the nebulizer 1 against further actuation, preferably against further tensioning of the drive spring 7 and/or against rotating of the housing part 18. This is preferably realized in that the rotation of the member 50 flexes the lock 57 or portion 59 of the locking member 58 radially outwards so that the flexed portion 59 leaves its non-locking position, into which it is biased, and locks further rotation of the inner part 17 relative to the upper housing part 16. This locking is in particularly achieved in that a free end of the portion 59 engages into a respective toothing or against respective abutment surfaces formed at the inner surface of the upper housing part 16. In this respect it has to be noted that the device 48 is preferably arranged or mounted on inner part 17, particular on its upper part 17a, wherein the preferably ring-like locking member 58 is preferably arranged around the rotatable member 50. The locking member 58 is preferably secured against rotation relative to the inner part 17 by respective form fit engagement, preferably of the inner part 17 or at least one protrusion 17c thereof into a recess 65 of the locking member 58. In the present embodiment, the recess 65 is preferably formed like a pocket or a portion cut-out of the periphery from one axial side. In particular, the locking member 58 may be provided with two or more recesses 65 as schematically shown in FIGS. 14 and 15, for engagement of respective protrusions 17c or the like, in particular of the associated inner part 17. However, other constructional solutions are possible as well.

Consequently, only member 50 is rotatable relative to inner part 17 and, thus, to locking member 58. However, locking member 58 is rotatable together with inner part 17 relative to upper housing part 16.

As already mentioned, the control member 50 is moveable, in particular rotatable, relative to locking member 58. This relative rotation is meant when any rotation or indexing of the control member 50 is mentioned. In this context, it has to be considered that the device 48 and the locking member 58 are rotated together with the inner part 17, but this rotation is different as this is the movement for tensioning the energy store, here spring 7, and/or for delivering or sucking fluid 2 out of the container 3 by in particular axial movement of the conveying element or tube 9.

The construction mentioned above, results in that the device 48 is rotated together with the inner part 17 each time the lower housing part 18 is rotated, i.e. when tensioning the drive spring 7. This rotation is preferably performed in 180° steps. Therefore, the device 48 or indicator member 50 comprises preferably two sets of respective number 52 and/or symbols 53 that are shown alternately through the window 49.

Thus, the member 50 comprises preferably two groups of numbers 52 and/or symbols 53, each group with the respective sequence of numbers 52 and/or symbols 53, wherein the groups are arranged offset by 180° on the member 50. This offset correspondence to the rotational angle for each rotational actuation of the lower housing part 18 and inner part 17 for tensioning the nebulizer 1/drive spring 7.

Preferably, the control portions 56 and/or the peripheral parts of the control member 50 in between the portion 56 form an inclined or control plane or surface cooperating with the portion 59 or its cam or corrugation 60 such that the lock 57 or the locking can be actuated alone by the force of the spring 51 acting on the member 50. In particular, the spring 51 or member 50 drives the lock 57. Further, the member 50 controls the lock 57 or the locking. As the member 50 also forms an indicator member, the indicator member drives the lock 57 or locking as well.

In the present embodiment, the locking member 58 is preferably arranged outside or around the control member 50 at least around a cylindrical main part of control member 50. In particular, the locking member 58 encompasses or covers at least substantially the cylindrical main part of the control member 50. The locking member 58 comprises preferably two openings 66 (shown in FIGS. 14 and 15) that are alternately aligned with window 49 depending on the rotational position of inner part 17 and, thus, of the locking member 58 so that the respective number 52 and/or symbol 53 is visible through the window 49 and through locking member 58.

In the first locked state, the member 50 is preferably stopped against further rotation by the protrusion 64 where any other part corresponding to the attachment of the housing part 18. When the housing part 18 is detached from the nebulizer 1 or its upper housing part 16 or inner part 17 for container replacement, this detachment is registered by unblocking the further movement or rotation of the member 50. In particular, a stop portion 54 of the member 50 which has been stopped by protrusion 64 or the like, can pass after detachment of the housing part 18 so that the member 50 can index one step further. In this further rotational position, the nebulizer 1 is still in its first locked state, i.e. is still locked against further use, in particular against further actuation or tensioning of the drive spring 7. However, the member 50 may show the next symbol 53, in particular an arrow pointing upwards, indicating that a new container 3 has to be connected and/or that a new housing part 18 has to be connected to the nebulizer 1. This situation correspondents to the initial situation before first assembly of the nebulizer 1 with the housing part 18 as already described.

It has to be noted that the stop element 8 is preferably blocked against actuation, in particular against release of the holder 6 and drive spring 7 in the first locked state. This actuation locking will also be achieved by the device 48 or member 50.

When the housing part 18 and the associated container 3 have been replaced, this is registered by the device 48, in particular by actuation of the corresponding stop element 61 by means of the protrusion 64. Then the member 50 indexes one step further and shows the next container number 52. Then, the lock 57 is reset, i.e. opened or unlocked again. Thus, the nebulizer 1 is unlocked and can be used further with the new container 3. Simultaneously, the container 3 or housing part 18 is preferably locked again against opening or container replacement, in particular in that the next blocking portion 55 is positioned below retaining element 19 to prevent actuation of the retaining element 19 which is necessary for opening the nebulizer 1.

The above sequence can be repeated, i.e. new containers 3 and new housing parts 18 can be used one after the after with the nebulizer 1, wherein the device 48 or indicator member 50 displays or shows the container number 52 and, preferably, symbols 53 for user guidance, in particular to indicate any necessary container replacement and/or indicating to open and close the nebulizer 1 or the like. The container number 52 relates in particular to the number of containers 3 that have already been used with the nebulizer 1 or still can be used with the nebulizer 1. In particular, one or more symbols 53 are displayed or shown alternately with the consecutive container numbers 52. This is realized preferably by one comment component, namely indicator member 50. However, other constructional realizations are possible.

Further, the display of the container numbers 52 and/or symbols 53 works preferably only mechanical.

In particular, the device 48 and/or the lock 57 work only mechanical.

After a predetermined number of containers 3 have been connected to or with the nebulizer 1, the nebulizer 1 will be blocked against further container replacement. After using the lastly inserted or connected container 3, the nebulizer 1 will enter the final locked state, i.e. the second locked state, preferably where the lock 57 or nebulizer 1 is blocked against resetting and/or the nebulizer 1 or housing part 18 is blocked against opening. This second locked state is entered in particular after the predetermined number of operations has been reached or exceeded with the ultimate, current container 3. Similar to the previous process the counter device 23 or its rider 44 or actuation part 47 actuates the device 48, in particular the corresponding stop element 61 to allow to index the member 50 one step further into its final rotational position. Thus, the second locked state is entered.

In the second lock state, the control member 50 cannot be rotated any further. This is realized in the present embodiment in particular in that the bearing portion 67 abuts one protrusion 17c of the inner part 17 engaging into one of the recesses 65. However, other constructional solutions are possible in order to realize the desired rotational stop or blocking for the control member 50 in the final rotational position, i.e. in the second locked state.

In the second locked state, the device 48 or member 50 does not allow opening of the nebulizer 1 or housing part 18 as it would be in the case in the first locked state. Instead, the member 50 comprises a respectively designed, preferably sufficiently long blocking portion 55 to block the retaining element 19 further against actuation and, thus, to block the nebulizer 1 against opening and container replacement.

In the second locked state, the nebulizer 1 can be locked against further actuation, in particular against tensioning of the drive spring 1 and/or rotation of the housing part 18 or inner part 17. This can be realized by actuating the lock 57, in particular by flexing portion 59 radially (preferably outwards) by the member 50 or its corresponding control portion 56. In the second locked state, the nebulizer 1 is preferably locked against any further discharge of fluid 2, in particular by blocking actuation of the stop element 8. This is preferably also realized by device 48.

Therefore, the nebulizer 1 cannot be used anymore after the second locked state has been entered. The second locked state is not reversible. In particular, resetting or unlocking of the lock 57 is not possible, but prevented in the second locked state.

As already outlined above, some general aspects or ideas of the nebulizer 1 according to the preferred embodiment can be summarized as indicated in the following.

The device 48 consists preferably only of two parts (control member 50 and locking member 58) or three parts (control member 50, spring 51 and locking member 58), but provides multiple functions, in particular displaying of numbers 42 and/or symbols 53 and/or user instructions, locking of the nebulizer 1 against further use, locking of the nebulizer 1 against tensioning, and/or locking of the nebulizer 1 against opening or container replacement.

The nebulizer 1 may comprise the indicator member 50 for showing numbers, in particular container numbers 52 and alternately symbols 53 indicating container replacement and/or nebulizer opening and/or closing.

The indicator member 50 may be moved or rotated stepwise by the force of the spring 51.

The indicator member 50 may drive the lock 57 of the nebulizer 1 such that the nebulizer 1 is locked against further use in the first locked state, when he container 3 has to be replaced, wherein the first locked state is reset by indexing the indicator member 50 and/or resetting the lock 57 if the container 3 and/or housing part 18 have been replaced.

The indicator member 50 is preferably ring-like.

The indicator member 50 works or shows the numbers 52 and/or symbols 53 mechanically.

The nebulizer 1 comprises preferably the lock 57 for locking the nebulizer 1 against further use in the first locked state, in particular when the container 3 has to be replaced.

Preferably, the first locked state is reset by resetting the lock 57, if the container 3 and/or housing part 18 have been replaced. With other words, the lock 57 is preferably resettable and can be used further after container replacement. In particular, an exchange or replacement of the lock 57 is not necessary to reuse the nebulizer 1.

The nebulizer 1 comprises preferably the control member 50 for controlling or driving the lock 57.

The control member 50 is preferably moved or rotated stepwise by the force of the spring 51.

The lock 57 and/or first locked state is preferably blocked against resetting in the second locked state.

The second locked state is preferably entered when a predetermined number of containers 3 has been used or inserted into the nebulizer 1 and, preferably after a predetermined number of operations has been performed or exceeded with the nebulizer 1 after inserting the last container 3.

The control member 50 is preferably ring-like.

Preferably, the control member 50 forms the indicator member or vice versa.

The control member 50 displays preferably the numbers 52 of containers 3 that have been used or still can be used and/or the symbols 53 indicating containing replacement and/or user guidance or nebulizer handling.

The control member 50 blocks preferably opening of the nebulizer 1 and/or container replacement until a predetermined number of operations has been reached or exceeded with the current container 3.

Preferably, the nebulizer 1 is locked against opening or container replacement, in particular by means of the control member 50, in the second locked state.

Preferably, the nebulizer 1 is locked against opening or container replacement, in particular by means of the control member 50, before the first locked state has been reached.

Preferably, the lock 57 locks the nebulizer 1 in the first and/or second locked state against conveying fluid 2 into the pressure generator 5 and/or against tensioning of the drive spring 7 of the nebulizer 1 and/or against rotation or turning of the housing part 18 or inner part 17.

Preferably, the housing part 18 has to be replaced each time the container 3 is replaced. In particular, the container 3 is inseparable from the housing part 18 and/or counter device 23 or vice versa.

The securing device 32, in particular its moved apart locking portions 33b, preferably prevent that the used and/or detached container 3 can be re-connected to or reused with the nebulizer 1 once more and or prevent that a used or detached housing part 18 can be reconnected to the nebulizer 1 once more.

Preferably, the housing part 18 can be or has to be detached or opened for replacing the container 3.

Preferably, the securing device 32 is associated to the container 3 preventing that a used container 3 can be connected or used with the nebulizer once more.

FIGS. 16 to 25 show preferred aspects and/or preferred modifications of the nebulizer 1 according to the present invention. The previous descriptions and explanations apply preferably in addition even if a repetition is omitted.

FIG. 16 shows the upper part 16 of the nebulizer 1 in a partial, schematic sectional view. FIG. 17 shows a schematic sectional view perpendicular to the plane of FIG. 16 essentially in the plane of the indicator/control member 50.

The nebulizer 1 comprises preferably a blocking device 68 which—in the tensioned state of the nebulizer 1 or energy store or drive spring 7—blocks opening of the nebulizer 1 or housing and/or blocks detachment of the housing part 18 and/or blocks indexing of the member 50.

In particular, the member 50, preferably the rotational position of member 50, controls locking and unlocking of the housing or housing part 18 or retaining element 19. Thus, the blocking device 68 blocks opening of the housing or detaching of the housing part 18 in the tensioned state of the nebulizer 1 preferably via or by means of the indicator/control member 50, in particular by selectively blocking indexing of a member 50.

Preferably, the housing of the nebulizer 1 is blocked against opening in a form-fit manner when the nebulizer 1 is in its tensioned state.

Preferably, the blocking device 68 comprises a blocking element 68a as shown in different perspective views in FIGS. 18 and 19.

The blocking device 68 or blocking element 68a comprises preferably a blocking part 68b for engaging or cooperating with the member 50 (see FIG. 17) and/or for blocking the member 50 against rotational indexing, when the nebulizer 1 or its energy store (drive string 7) is in the tensioned state.

The blocking part 68b protrudes or extends preferably radially.

The blocking element 68a or blocking part 68b is preferably moveable axially and/or selectively in engagement with member 50, in particular with a member recess 72, and out of engagement.

Preferably, the blocking element 68a or blocking part 68b has different (axial) positions depending on the state of the nebulizer 1, namely tensioned or un-tensioned, and/or is moveable between different positions in response to the movement of the container 3 or holder 6 or drive spring 7 at its end at the holder 6.

Thus, by the cooperation of blocking part 68b with the member 50, the blocking device 68 preferably always blocks the member 50 against rotational indexing, when the nebulizer 1 or its energy store (drive string 7) is in the tensioned state.

FIGS. 16 and 17 show the nebulizer 1 in the tensioned state. The blocking device 68 blocks opening of the nebulizer 1. In particular, the blocking device 68 or its blocking element 68a blocks indexing of the member 50. The blocking element 68a or blocking part 68b engages preferably into member 50 or a member recess 72 such that member 50 cannot index one step further even if the predetermined number of uses of the nebulizer 1 with the current container 3 has been reached or exceeded, i.e. even if when the rider 44 or actuation part 47 has reached the upper axial position and actuated the respective stop element 61 or contact element 61a so that the member 50 should be free to index into the first or second locked state. However, the member 50 is blocked against indexing by the blocking device 68 or blocking part 68b until the nebulizer 1 is non-tensioned, i.e. the energy store or drive spring 7 is relaxed, and fluid 2 is dispensed for the last time from the current container 3.

Preferably, the blocking device 68 or its blocking part 68b prevent any indexing of the member 50 in the tensioned state of the nebulizer 1 independent on the position of the counter device 23 or its rider 44, i.e. each time the nebulizer 1 is tensioned.

The blocking element 68a is preferably received or guided in an inner recess of the inner part 17, in particular upper part 17a of inner part 17. The inner part 17 or upper part 17a comprises preferably at least one guiding element 71, in particular two guiding ribs or elements 71, in particular on opposite sides, for holding the blocking element 68a, in particular such that it can move axially relative to the inner part 17 and/or the member 50. Preferably, the blocking element 68a is snapped in a gliding rail or the like, here formed preferably by the guiding elements 71.

In the present embodiment, the blocking device 68 or blocking element 68a or blocking part 68b is moved or driven preferably by the movement of the container 3, the drive spring 7 or the holder 6. In particular, the blocking device 68 or blocking element 68a engages with an engagement part 68g into a holder recess 69 formed in the holder 6. In particular, the engagement or coupling of the blocking device 68 or blocking element 68a with the holder 6 or any other component driving or moving the blocking device 68 or blocking element 68a can be realized as a rigid connection or alternatively as a flexible or articulated engagement and/or as any other suitable drive connection e.g. with play, relative movability between the interconnected parts, an intermediate transmission element or the like.

In the tensioned state of the nebulizer the container 3, holder 6 and holder side of the drive spring 7 are in a different axial position than in the untensioned state. Thus, different positions of the blocking device 68 engaged to or triggered by at least one these components also correspond to the tensioned and untensioned state of the nebulizer 1, respectively.

In the present embodiment, the blocking device 68 or blocking element 68a comprises in addition to the blocking part 68b preferably a base 68c and/or guiding part 68d.

The base 68c holds preferably the blocking part 68b which protrudes preferably radially outwardly from the blocking element 68a or base 68c.

The guiding part 68d is provided preferably with noses 68e, in particular at opposite sides and respectively offset, such that the blocking element 68a or guiding part 68d is moveably guided and held by means of the guiding elements 71 of the inner part 17 engaging in between the noses 68e. However, other constructional solutions are possible as well.

The blocking device 68 or blocking element 68a comprises preferably an arm 68f for holding the engagement part 68g. In the present embodiment, the arm 68f extends essentially in axial direction and is inclined from the inner part 17 to the holder 6 within the inner part 17 so that the engagement part 68g can preferably completely sit in or engage into the holder recess 69 of the holder 6.

Generally it is possible to connect the engagement part 68g and, thus, the blocking element 68a, rigidly with one of the components, in particular the holder 6, for following the axial movement, in particular over the entire axial stroke. However, it is also possible to reduce the stroke of the engagement part 68g and, thus, of the blocking element 68a in comparison to the stroke of the container 3, holder 6 and the like, wherein different end stops limiting the stroke of the blocking element 68a can be provided, as it is preferred in the present embodiment.

In particular, the engagement part 68g has play (i.e. can move relative to the holder 6) in the holder recess 69 in the axial direction of movement. Alternatively or additionally, the holder recess 69 may be open towards the drive spring 7 so that the end of the drive spring 7 forms one (axial) end stop for the engagement part 63g and, thus, for the blocking element 68a. The other or upper end stop 69a is preferably formed by the other end of the holder recess 69, as shown in FIG. 16. However, the holder recess 69 could form both end stops if desired.

The position of the end stops define the end of the movement of the engagement part 68g relative to the axial stroke or movement of the container 3 and holder 6 and, thus, defines the coupling.

In the present embodiment, the holder recess 69 is preferably open towards the drive spring 7, but forms the upper end stop 69a as indicated in FIG. 16. The lower end stop is preferably formed by the drive spring 7, more precisely by its upper end, but could be formed by any suitable component.

The engagement part 68g follows—at least partly, in particular depending on the position of the end stops—the axial movement of the holder 6 and/or drive spring 7 and, thus, the back and forth movement of the container 3. This drive movement of the engagement part 68g preferably transmitted by arm 68f controls, moves or drives the blocking device 68 or blocking element 68a, in particular the blocking part 68b.

The orientation or position, such as upwards, downwards, upper, lower or the like mentioned above or used in the following, refers to the usual orientation of the nebulizer 1 or container 3 where the nebulizer 1 is at least essentially vertical and/or the outlet, nozzle 12 or mouthpiece 13 points upwards and/or the housing part 18 is at the bottom of the nebulizer 1 and/or the axial direction of the container 3 or its movement is vertical and/or the fluid outlet 24 or head of the container 3 is directed vertically upwards.

The counter device 23 is preferably driven by the movement, in particular rotation, of the housing part 18 or inner part 17 relative to the housing or upper part 16 for tensioning the nebulizer 1, energy store or drive spring 7. Thus, the counter device 23 or its rider 44 or actuation part 47 will reach its final axial end position (upper position) when the nebulizer 1 is tensioned for the last time. In this end position, the counter device 23 or its rider 44 or actuation part 47 unlocks the member 50 in particular by flexing stop element 61 or contact element 61a out of locking engagement with member 50 or the respective stop portion 54. However, the blocking device 68 or blocking part 68b still prevents the member 50 from indexing one step further into the first or second locked state until the nebulizer 1 has been actuated for the last time with the present container 3 to relax the energy store or drive spring 7.

The actuation of the nebulizer 1, i.e. release of drive spring 7, results namely in that the holder 6 and container 3 move axially towards the mouthpiece 13, i.e. upwards, and, simultaneously the blocking device 68 or its blocking part 68b is moved out of engagement with member recess 72 or member 50 so that member 50 is free to index one step into the first or second locked state.

In the present embodiment, the upper end of the drive spring 7 forms the lower end stop which abuts at the lower end of the engagement part 68g of the blocking element 68a and finally moves the blocking part 68b out of engagement with member recess 72 or member 50 when the holder 6 and container 3 move upwards.

It has to be noted that during each downward movement of the holder 6 or during each tensioning of the nebulizer 1 or drive spring 7, the holder 6 or more precisely, the upper end stop 69a, moves or pushes the engagement part 68g and, thus, the blocking element 68a downwards and/or into engagement with member 50, in particular such that blocking part 68b moves axially into member 50 or its member recess 72.

In the first locked state, the member 50 unlocks the retaining element 19 so that the nebulizer 1 or its housing can be opened, in particular the housing part 18 can be detached, for replacing the container 3, in particular together with the housing part 18 and counter device 23.

It has to be noted that the member 50 comprises preferably multiple engagement possibilities, in particular member recesses 72, so that the blocking device 68 or blocking part 68b can engage into the respective member recess 72 depending on the actual rotational position of the member 50 in response to the actual number of containers 3 already used.

FIG. 20 shows in a schematic section an upper part of the nebulizer 1. The nebulizer 1 comprises preferably an indicator device 73 for indicating the state, in particular a tensioned state, of the nebulizer 1. In particular, the indicator device 73 indicates a tensioned state of the nebulizer 1 and a non-tensioned state of the nebulizer 1.

FIG. 20 shows the nebulizer 1 in the non-tensioned state. The stop element 8 is depressed or moved to the left side in the present representation.

FIG. 21 shows a similar schematic section of nebulizer 1 as FIG. 20, wherein the nebulizer 1 is in the tensioned state. Here, the stop element 8 is in its blocking position where it is moved to the right side in the present representation and where it blocks upward movement of the holder 6 and, thus, of the container 3.

In the present embodiment, the indicator device 73 comprises preferably an indicator element 74. The indicator element 74 is preferably driven or moveable, in particular pivotable, by the stop element 8.

In the present embodiment, the indicator device 73 or indicator element 74 comprises preferably at least one indicator portion 75 with preferably different colors, symbols or the like for indicating the (pivotable) position of the indicator element 74 and/or of the stop element 8 and, thus, the state of the nebulizer 1 (tensioned or non-tensioned).

The nebulizer 1 or its upper part 16 comprises preferably a window 78 for viewing at least part of the indicator element 74 or indicator portion 75 to indicate the state.

In the present embodiment, the indicator element 74 comprises preferably an engagement portion 76, e.g. a protrusion, bolt or the like. The stop element 8 comprises preferably a drive portion 77, which is preferably fork-like and/or engages the engagement portion 76 for driving or moving, in particular pivoting, the indicator element 74 depending on the (radial) position of the stop element 8. However, other constructional solutions for coupling or linking the stop element 8 with the indicator device 73 are possible.

FIG. 22 shows the nebulizer 1 in a schematic sectional view without inner components, in particular without container 3, drive spring 7, holder 6, pressure generator 5 and nozzle 12. In FIG. 22, the housing part 18 is detached. FIG. 23 shows the nebulizer 1 in a similar schematic section as FIG. 22, wherein the housing part 18 is partly attached to the nebulizer 1 or inner part 17. FIG. 24 shows the nebulizer 1 in a similar schematic section as FIG. 22, wherein the housing part 18 is completely attached to the nebulizer 1 or inner part 17. FIG. 25 shows a partial enlargement of the encircled area of FIG. 24.

The nebulizer 1 comprises preferably a manually depressable actuator member 79, in particular in the form of a button or the like, at the housing part 18. Preferably, the actuator member 79 is received or held in a housing recess 81 formed at or by the housing part 18.

In the present embodiment, the actuator member 79 is preferably connected with or held by an actuator portion 80 or formed as a unitary piece with the actuator portion 80. Preferably, the actuator portion 80 is for securing the actuator member 79 at the housing part 18 and/or biasing the actuator member 79 into its non-depressed position shown in FIGS. 22 to 25.

Preferably, the retaining element 19 is connected with and not detachable from the nebulizer 1 or its inner part 17, i.e. is separated from the housing part 18 when detaching the housing part 18, as it is the case e.g. in the embodiment shown in FIGS. 7 and 9. However, in the preferred modification, the actuator member 79 is a separate part and is not formed by or connected with the retaining element 19, but separated therefrom when detaching the housing part 18 from the nebulizer 1 or inner part 17. This facilitates handling because the user (not shown) can leave a finger on the actuator member 79 when pulling the housing part 18 from the inner part 17 for opening the housing.

The housing part 18 comprises preferably a holding portion 82, in particular a shoulder or nose formed at the side of the housing recess 81 and/or adjacent to the actuator member 79, for interacting or cooperating with at the retaining element 19 or a retaining shoulder 83 of the retaining element 19.

FIG. 23 shows a partly attached or detached position of the housing part 18. Here, the holding portion 82 can engage into a retaining recess 84 formed at the retaining element 19 for holding the holding part 18 in this position.

Preferably, the retaining recess 84 and/or holding portion 82 comprises respectively inclined surfaces so that it is possible only to push the housing part 18 completely on the inner part 17, i.e. to completely close the housing, without actuating or depressing the actuator member 79 so that the nebulizer 1 can be completely closed as shown in FIGS. 24 and 25.

In the completely closed state, the holding portion 82 extends preferably over the retaining shoulder 83 so that the housing part 18 is secured in form-fit manner at the nebulizer 1 or inner part 17 or retaining element 19.

When depressing the actuator member 79, the retaining element 19 can flex inwardly (if not blocked by a blocking portion 55 of the member 50 as shown e.g. in FIG. 9) to move the retaining shoulder 83 inwards so that the housing part 18 can pass with its retaining shoulder 83 when detaching the housing part 18 in axial direction from the nebulizer 1.

The retaining element 19 comprises preferably a retaining portion 85 which extends towards the member 50 and can be selectively blocked against depression by the blocking portion 55 depending on the rotational position of the member 50. In FIGS. 22 to 25, the schematically shown blocking portion 55 adjacent to the retaining element 19 or retaining portion 85 is preferably circumferentially offset due to the rotational position of the member 50, so that the retaining portion 85 can move axially inwardly when the actuator member 79 is depressed and/or when attaching the housing part 18 to the nebulizer 1 and the passing of holding portion 82 results in an inward movement of the retaining element 19.

It has to noted that the blocking of opening of the nebulizer 1, i.e. the blocking of detaching the housing part 18 from the nebulizer 1 or inner part 17, functions in the previous embodiment preferably in a similar manner, namely by blocking the retaining element 19 against depression by means of one of the blocking portions 55 depending on the rotational position of the member 50 (compare FIG. 9 for example).

As already mentioned, individual features, aspects and/or principles of the embodiments described may also be combined with one another as desired and may be used particularly in the nebulizer according to FIGS. 1 and 5 but also in similar or different nebulizers.

Unlike freestanding equipment or the like the proposed nebulizer 1 is preferably designed to be portable and in particular is a mobile hand operated device.

The proposed solution may, however, be used not only in the nebulizers 1 specifically described here but also in other nebulizers or inhalers, e.g. powder inhalers or so-called metered dose inhalers.

Preferably, the fluid 2 is a liquid, as already mentioned, especially an aqueous pharmaceutical formulation or an ethanolic pharmaceutical formulation. However, it may also be some other pharmaceutical formulation, a suspension or the like.

According to an alternative embodiment the fluid 2 may also comprise particles or powder. In this case, instead of the expulsion nozzle 12, some other kind of supply device may be provided, especially an expulsion opening (not shown) or a supply channel (not shown) for supplying the fluid to or powder or the like into the mouthpiece 13. The optional air supply opening 15 then serves to supply ambient air preferably in parallel so as to general or allow an airflow with a sufficient volume for breathing in or inhaling through the mouthpiece 13.

If necessary the fluid 2 may also be atomized by means of a propellant gas.

Preferred ingredients and/or formulations of the preferably medicinal fluid 2 are listed in particular in WO 2009/115200 A1, preferably on pages 25 to 40, or in EP2 614 848 A1, paragraphs 0040 to 0087, which are incorporated herewith by reference. In particular, these may be aqueous or non-aqueous solutions, mixtures, formulations containing ethanol or free from any solvent, or the like.

LIST OF REFERENCE NUMERALS

1 nebulizer

2 fluid

3 container

4 bag

5 pressure generator

6 holder

7 drive spring

8 stop element

9 conveying tube

10 non-return valve

11 pressure chamber

12 nozzle

13 mouthpiece

14 aerosol

15 air supply opening

16 upper housing part

17 inner part

17
a upper part of the inner part

17
b lower part of the inner part

17
c protrusion

18 housing part (lower part)

19 retaining element

20 spring

21 container base

22 piercing element

23 counter device

24 fluid outlet

25 first closure

26 second closure

27 closure part

28 flange

29 transportation lock

30 securing member

31 venting hole

32 securing device

33 holding element

33
a end portion

33
b locking portion

33
c protrusion

34 locking element

34
a end portion

34
b actuation portion

35 base

36 spring portion

37 fixing portion

38 edge

39 retaining part

40 securing part

41 guiding surface

42 threaded shaft

43 drive gear

44 rider

45 toothing

46 pointer

47 actuation part

48 device

49 window

50 indicator/control member

51 spring

52 number

53 symbol

54 stop portion

55 blocking portion

56 control portion

57 lock

58 locking member

59 tongue-like portion

60 corrugation

61 stop element

61
a contact element

62 rib

63 coding portion

64 protrusion

65 recess

66 opening

67 bearing portion

68 blocking device

68
a blocking element

68
b blocking part

68
c base

68
d guiding part

68
e nose

68
f arm

68
g engagement part

69 holder recess

69
a end stop

70 inner recess

71 guiding element

72 member recess

73 indicator device

74 indicator element

75 indicator portion

76 engagement portion

77 drive portion

78 window

79 actuator member

80 actuator portion

81 housing recess

82 holding portion

83 retaining shoulder

84 retaining recess

85 retaining portion

Claims

1. A nebulizer (1) for a fluid (2), comprising: a container (3) containing the fluid (2);a housing part (18) which can be detached from the nebulizer (1) for replacing the container (3);an inner part (17);a retaining element (19) connected with and not detachable from the inner part (17), wherein the housing part (18) is releasable fixed to the inner part (17) by the retaining element (19);a delivery mechanism for dispensing the fluid (2); anda manually depressible actuator member (79), which is a separate part from the retaining element (19) and acts on the retaining element (19),wherein the actuator member (79) is depressed to elastically deform or flex the retaining element (19) to allow detachment of the housing part (18).
2. The nebulizer according to claim 1, wherein the housing part (18) forms a cap-like lower housing part and fits around or over a lower free end portion of the container (3).
3. The nebulizer according to claim 1, wherein the retaining element (19) forms a catch or snap for automatically holding or securing the housing part (18) when it is shifted onto or into the nebulizer (1).
4. The nebulizer according to claim 1, wherein the housing part (18) comprises a holding portion (82) for interacting or cooperating with the retaining element (19) or a retaining shoulder (83) of the retaining element (19).
5. The nebulizer according to claim 4, wherein, when depressing the actuator member (79), the retaining element (19) flexes inwardly to move the retaining shoulder (83) inwards, so that the housing part (18) passes the retaining shoulder (83) when detaching the housing part (18) in axial direction from the nebulizer (1).
6. The nebulizer according to claim 1, wherein the retaining element (19) is adapted to hold or secure the housing part (18) with two catch positions, i.e. a first catch position with partly closed housing part (18) of the nebulizer (1) and a second catch position with completely closed housing part (18).
7. The nebulizer according to claim 1, wherein the actuator member (79) is connected with or held by an actuator portion (80).
8. The nebulizer according to claim 7, wherein the actuator portion (80) biases the actuator member (79) into its non-depressed position.
9. The nebulizer according to claim 1, wherein the actuator member (79) is detachable together with the housing part (18) from the nebulizer (1).
10. The nebulizer according to claim 1, wherein the actuator member (79) is received or held in a housing recess (81) formed at or by the housing part (18).
11. The nebulizer according to claim 1, wherein the nebulizer (1) comprises a blocking device (68) adapted to block, when the nebulizer (1) is in a tensioned or loaded state, opening of the housing and/or indexing of an indicator member (50) which shows numbers (52) and/or symbols (53).
12. The nebulizer according to claim 11, wherein the retaining element (19) is blocked against deforming or flexing by the blocking device (68) or indicator member (50) in the tensioned state.
13. The nebulizer according to claim 11, wherein the blocking is terminated automatically after dispensing a dose of fluid (2).
14. The nebulizer according to claim 11, wherein the blocking device (68) blocks rotation of a control member (50) and/or of the indicator member (50) in the tensioned state.
15. The nebulizer according to claim 14, wherein the control member (50) and/or indicator member (50) controls the opening of the housing and/or locks the nebulizer or housing part (18) selectively against opening.
16. The nebulizer according to claim 11, wherein the blocking device (68) is driven, controlled or actuated by a position or movement of the container (3) within the housing and/or by a position or movement of a holder (6) holding the container (3) within the housing and/or by a position or movement of a drive spring (7).
17. The nebulizer according to claim 11, wherein the blocking device (68) comprises a blocking element (68a) which is axially moveably held by the inner part (17) of the nebulizer (1), where the inner part (17) is rotatable.
18. The nebulizer according to claim 11, wherein the housing is blocked against opening and/or container replacement until the container (3) has to be replaced due to multiple dispensing of fluid (2) and until the nebulizer (1) or an energy store has been released by dispensing fluid (2) or is in a non-tensioned state.

Priority Claims (1)

Number	Date	Country	Kind
13003987	Aug 2013	WO	international

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 15/942,737, accorded a filing date of Apr. 2, 2018, which is a continuation of U.S. patent application Ser. No. 14/453,805, accorded a filing date of Aug. 7, 2014 (issued U.S. Pat. No. 10,004,857 on Jun. 26, 2018), which claims priority to EP Application No. 13003987.8, filed Aug. 9, 2013, the entire disclosures of which are hereby incorporated by reference.

US Referenced Citations (529)

Number	Name	Date	Kind
1828864	Hopkins	Oct 1931	A
2015970	Schoene	Oct 1935	A
2127401	Gillican	Aug 1938	A
2161071	McGrath et al.	Jun 1939	A
2321428	Schloz	Jun 1943	A
2329311	Waters	Sep 1943	A
2362103	Smith	Nov 1944	A
2651303	Johnson et al.	Sep 1953	A
2720969	Kendall	Oct 1955	A
2793776	Lipari	May 1957	A
2974880	Stewart et al.	Mar 1961	A
3032823	Sherman et al.	May 1962	A
3157179	Allen et al.	Nov 1964	A
3172568	Modderno	Mar 1965	A
3196587	Hayward et al.	Jul 1965	A
3223289	Bouet	Dec 1965	A
3299603	Shaw	Jan 1967	A
3348726	La Cross	Oct 1967	A
3354883	Southerland	Nov 1967	A
3425591	Pugh, Sr.	Feb 1969	A
3440144	Anderson et al.	Apr 1969	A
3457694	Tatibana	Jul 1969	A
3491803	Galik	Jan 1970	A
3502035	Fedit	Mar 1970	A
3580249	Takaoka	May 1971	A
3590557	Vogel	Jul 1971	A
3606106	Yuhas	Sep 1971	A
3632743	Geller et al.	Jan 1972	A
3655096	Easter	Apr 1972	A
3674060	Ruekberg	Jul 1972	A
3675825	Morane	Jul 1972	A
3684124	Song	Aug 1972	A
3802604	Morane et al.	Apr 1974	A
3817416	Costa	Jun 1974	A
3820698	Franz	Jun 1974	A
3842836	Ogle	Oct 1974	A
3858580	Ogle	Jan 1975	A
3861851	Schiemann	Jan 1975	A
3870147	Orth	Mar 1975	A
3924741	Kachur et al.	Dec 1975	A
3933279	Maier	Jan 1976	A
3946732	Hurscham	Mar 1976	A
3949751	Birch et al.	Apr 1976	A
3951310	Steiman	Apr 1976	A
3953995	Haswell et al.	May 1976	A
3973603	Franz	Aug 1976	A
4012472	Lindsey	Mar 1977	A
4031892	Hurschman	Jun 1977	A
4036439	Green	Jul 1977	A
4048997	Raghavachari et al.	Sep 1977	A
4067499	Cohen	Jan 1978	A
4094317	Wasnich	Jun 1978	A
4120995	Phipps	Nov 1978	A
4126559	Cooper	Nov 1978	A
4153689	Hirai et al.	May 1979	A
4174035	Wiegner	Nov 1979	A
4177938	Brina	Dec 1979	A
4178928	Tischlinger	Dec 1979	A
4195730	Hunt	Apr 1980	A
4245788	Wright	Jan 1981	A
4275840	Staar	Jun 1981	A
4315570	Silver et al.	Feb 1982	A
4338765	Ohmori et al.	Jul 1982	A
4377106	Workman et al.	Mar 1983	A
4434908	French	Mar 1984	A
4456016	Nowacki et al.	Jun 1984	A
4463867	Nagel	Aug 1984	A
4467965	Skinner	Aug 1984	A
4474302	Golderberg	Oct 1984	A
4476116	Anik	Oct 1984	A
4515586	Mendenhall et al.	May 1985	A
4516967	Kopfer	May 1985	A
4524888	Tada	Jun 1985	A
4603794	DeFord et al.	Aug 1986	A
4677975	Edgar et al.	Jul 1987	A
4727985	McNeirney et al.	Mar 1988	A
4749082	Gardiner et al.	Jun 1988	A
4796614	Nowacki et al.	Jan 1989	A
4805377	Carter	Feb 1989	A
4813210	Masuda et al.	Mar 1989	A
4821923	Skorka	Apr 1989	A
4840017	Miller et al.	Jun 1989	A
4863720	Burghart et al.	Sep 1989	A
4868582	Dreinhoff	Sep 1989	A
4885164	Thurow	Dec 1989	A
4905450	Hansen et al.	Mar 1990	A
4926613	Hansen	May 1990	A
4951661	Sladek	Aug 1990	A
4952310	McMahan et al.	Aug 1990	A
4964540	Katz	Oct 1990	A
RE33444	Lerner	Nov 1990	E
4973318	Holm et al.	Nov 1990	A
4979941	Ogle, II	Dec 1990	A
4982875	Pozzi et al.	Jan 1991	A
5014492	Fiorini et al.	May 1991	A
5025957	Ranalletta et al.	Jun 1991	A
5059187	Sperry et al.	Oct 1991	A
5060791	Zulauf	Oct 1991	A
5067655	Farago et al.	Nov 1991	A
5156918	Marks et al.	Oct 1992	A
5174366	Nagakura et al.	Dec 1992	A
5207217	Cocozza et al.	May 1993	A
5230884	Evans et al.	Jul 1993	A
5237797	Varlet	Aug 1993	A
5246142	DiPalma et al.	Sep 1993	A
5261565	Drobish et al.	Nov 1993	A
5263842	Fealey	Nov 1993	A
5271153	Reiboldt et al.	Dec 1993	A
5282304	Reiboldt et al.	Feb 1994	A
5282549	Scholz et al.	Feb 1994	A
5284133	Burns et al.	Feb 1994	A
5289948	Moss et al.	Mar 1994	A
5339990	Wilder	Aug 1994	A
5352196	Haber et al.	Oct 1994	A
5380281	Tomellini et al.	Jan 1995	A
5385140	Smith	Jan 1995	A
5388572	Mulhauser	Feb 1995	A
5394866	Ritson et al.	Mar 1995	A
5408994	Wass et al.	Apr 1995	A
5433343	Meshberg	Jul 1995	A
5435282	Haber et al.	Jul 1995	A
5435884	Simmons et al.	Jul 1995	A
5451569	Wong et al.	Sep 1995	A
5456522	Beach	Oct 1995	A
5456533	Streiff et al.	Oct 1995	A
5472143	Bartels et al.	Dec 1995	A
5482030	Klein	Jan 1996	A
5487378	Robertson et al.	Jan 1996	A
5497944	Weston et al.	Mar 1996	A
5499750	Manifold	Mar 1996	A
5499751	Meyer	Mar 1996	A
5503869	Van Oort	Apr 1996	A
5509404	Lloyd et al.	Apr 1996	A
5518147	Peterson et al.	May 1996	A
5533994	Meyer	Jul 1996	A
5541569	Jang	Jul 1996	A
5544646	Lloyd et al.	Aug 1996	A
5547094	Bartels et al.	Aug 1996	A
5569191	Meyer	Oct 1996	A
5574006	Yanagawa	Nov 1996	A
5579760	Kohler	Dec 1996	A
5584285	Salter et al.	Dec 1996	A
5593069	Jinks	Jan 1997	A
5599297	Chin et al.	Feb 1997	A
5603943	Yanagawa	Feb 1997	A
5614172	Geimer	Mar 1997	A
5622162	Johansson et al.	Apr 1997	A
5622163	Jewett et al.	Apr 1997	A
5643868	Weiner et al.	Jul 1997	A
5662098	Yoshida	Sep 1997	A
5662271	Weston	Sep 1997	A
5676930	Jager et al.	Oct 1997	A
5685846	Michaels, Jr.	Nov 1997	A
5697242	Halasz et al.	Dec 1997	A
5709202	Lloyd et al.	Jan 1998	A
5722598	Werding	Mar 1998	A
5738087	King	Apr 1998	A
5740967	Simmons et al.	Apr 1998	A
5763396	Weiner et al.	Jun 1998	A
5775321	Alband	Jul 1998	A
5782345	Guasch et al.	Jul 1998	A
5827262	Neftel et al.	Oct 1998	A
5829435	Rubsamen et al.	Nov 1998	A
5833088	Kladders et al.	Nov 1998	A
5848588	Foley et al.	Dec 1998	A
5868287	Kurokawa et al.	Feb 1999	A
5881718	Mortensen et al.	Mar 1999	A
5884620	Gonda et al.	Mar 1999	A
5902298	Niedospial, Jr. et al.	May 1999	A
5934272	Lloyd et al.	Aug 1999	A
5935101	Kato et al.	Aug 1999	A
5941244	Yamazaki et al.	Aug 1999	A
5950016	Tanaka	Sep 1999	A
5950403	Yamaguchi et al.	Sep 1999	A
5951882	Simmons et al.	Sep 1999	A
5964416	Jaeger et al.	Oct 1999	A
5975370	Durliat	Nov 1999	A
5997263	Van Lintel et al.	Dec 1999	A
6041777	Faithfull et al.	Mar 2000	A
6041969	Parise	Mar 2000	A
6053368	Geimer	Apr 2000	A
6062430	Fuchs	May 2000	A
6098618	Jennings et al.	Aug 2000	A
6109479	Ruckdeschel	Aug 2000	A
6110247	Birmingham et al.	Aug 2000	A
6116233	Denyer et al.	Sep 2000	A
6119853	Garrill et al.	Sep 2000	A
6120492	Finch et al.	Sep 2000	A
6123068	Lloyd et al.	Sep 2000	A
6131566	Ashurst et al.	Oct 2000	A
6145703	Opperman	Nov 2000	A
6149054	Cimillo et al.	Nov 2000	A
6152296	Shih	Nov 2000	A
6171972	Mehregany et al.	Jan 2001	B1
6176442	Eicher et al.	Jan 2001	B1
6179118	Garrill et al.	Jan 2001	B1
6186409	Srinath et al.	Feb 2001	B1
6199766	Fox et al.	Mar 2001	B1
6223933	Hochrainer et al.	May 2001	B1
6224568	Morimoto et al.	May 2001	B1
6237589	Denyer et al.	May 2001	B1
6259654	de la Huerga	Jul 2001	B1
6267154	Felicelli et al.	Jul 2001	B1
6279786	de Pous et al.	Aug 2001	B1
6302101	Py	Oct 2001	B1
6315173	Di Giovanni et al.	Nov 2001	B1
6319943	Joshi et al.	Nov 2001	B1
6336453	Scarrott et al.	Jan 2002	B1
6341718	Schilthuizen et al.	Jan 2002	B1
6349856	Chastel	Feb 2002	B1
6352152	Anderson et al.	Mar 2002	B1
6352181	Eberhard et al.	Mar 2002	B1
6363932	Forchione et al.	Apr 2002	B1
6375048	van der Meer et al.	Apr 2002	B1
6392962	Wyatt	May 2002	B1
6395331	Yan et al.	May 2002	B1
6401710	Scheuch et al.	Jun 2002	B1
6401987	Oechsel et al.	Jun 2002	B1
6402055	Jaeger et al.	Jun 2002	B1
6405872	Ruther et al.	Jun 2002	B1
6412659	Kneer	Jul 2002	B1
6419167	Fuchs	Jul 2002	B1
6423298	McNamara et al.	Jul 2002	B2
6427682	Klimowicz et al.	Aug 2002	B1
6446054	Mayorga Lopez	Sep 2002	B1
6457658	Srinath et al.	Oct 2002	B2
6464108	Corba	Oct 2002	B2
6481435	Hochrainer et al.	Nov 2002	B2
6491897	Freund et al.	Dec 2002	B1
6503362	Bartels et al.	Jan 2003	B1
6513519	Gallem	Feb 2003	B2
6543448	Smith et al.	Apr 2003	B1
6548647	Dietz et al.	Apr 2003	B2
6550477	Casper et al.	Apr 2003	B1
6565743	Poirier et al.	May 2003	B1
6578741	Ritsche et al.	Jun 2003	B2
6581596	Truitt et al.	Jun 2003	B1
6584976	Japuntich et al.	Jul 2003	B2
6606990	Stapleton et al.	Aug 2003	B2
6620438	Pairet et al.	Sep 2003	B2
6626309	Jansen et al.	Sep 2003	B1
6640805	Castro et al.	Nov 2003	B2
6641782	Mauchan et al.	Nov 2003	B1
6669176	Rock	Dec 2003	B2
6679254	Rand et al.	Jan 2004	B1
6685691	Freund et al.	Feb 2004	B1
6698421	Attolini	Mar 2004	B2
6706726	Meissner et al.	Mar 2004	B2
6708846	Fuchs et al.	Mar 2004	B1
6725858	Loescher	Apr 2004	B2
6729328	Goldemann	May 2004	B2
6732731	Tseng	May 2004	B1
6745763	Webb	Jun 2004	B2
6779520	Genova et al.	Aug 2004	B2
6789702	O'Connor et al.	Sep 2004	B2
6792945	Davies et al.	Sep 2004	B2
6823862	McNaughton	Nov 2004	B2
6825441	Katooka et al.	Nov 2004	B2
6846413	Kadel et al.	Jan 2005	B1
6866039	Wright et al.	Mar 2005	B1
6889690	Crowder et al.	May 2005	B2
6890517	Drechsel et al.	May 2005	B2
6915901	Feinberg et al.	Jul 2005	B2
6929004	Bonney et al.	Aug 2005	B1
6932962	Backstrom et al.	Aug 2005	B1
6942127	Raats	Sep 2005	B2
6964759	Lewis et al.	Nov 2005	B2
6977042	Kadel et al.	Dec 2005	B2
6978916	Smith	Dec 2005	B2
6986346	Hochrainer et al.	Jan 2006	B2
6988496	Eicher et al.	Jan 2006	B1
6994083	Foley et al.	Feb 2006	B2
7040311	Hochrainer et al.	May 2006	B2
7066408	Sugimoto et al.	Jun 2006	B2
7090093	Hochrainer et al.	Aug 2006	B2
7131441	Keller et al.	Nov 2006	B1
7152760	Peabody	Dec 2006	B1
7258716	Shekarriz et al.	Aug 2007	B2
7314187	Hochrainer et al.	Jan 2008	B2
7331340	Barney	Feb 2008	B2
7341208	Peters et al.	Mar 2008	B2
7380575	Stricklin	Jun 2008	B2
7417051	Banholzer et al.	Aug 2008	B2
7451876	Bossi et al.	Nov 2008	B2
7470422	Freund et al.	Dec 2008	B2
7556037	Klein	Jul 2009	B2
7559597	Mori	Jul 2009	B2
7571722	Wuttke et al.	Aug 2009	B2
7575003	Rasmussen	Aug 2009	B2
7579358	Boeck et al.	Aug 2009	B2
7611694	Schmidt	Nov 2009	B2
7611709	Bassarab et al.	Nov 2009	B2
7621266	Kladders et al.	Nov 2009	B2
7645383	Kadel et al.	Jan 2010	B2
7652030	Moesgaard et al.	Jan 2010	B2
7665461	Zierenberg et al.	Feb 2010	B2
7681811	Geser et al.	Mar 2010	B2
7686014	Boehm et al.	Mar 2010	B2
7717299	Greiner-Perth	May 2010	B2
7723306	Bassarab et al.	May 2010	B2
7743945	Lu et al.	Jun 2010	B2
7779838	Hetzer et al.	Aug 2010	B2
7802568	Eicher et al.	Sep 2010	B2
7819342	Spallek et al.	Oct 2010	B2
7823584	Geser et al.	Nov 2010	B2
7837235	Geser et al.	Nov 2010	B2
7849851	Zierenberg et al.	Dec 2010	B2
7896264	Eicher et al.	Mar 2011	B2
7980243	Hochrainer	Jul 2011	B2
7994188	Disse	Aug 2011	B2
8062626	Freund et al.	Nov 2011	B2
8104643	Pruvot	Jan 2012	B2
8167171	Moretti	May 2012	B2
8298622	Nakayama	Oct 2012	B2
8479725	Hausmann et al.	Jul 2013	B2
8495901	Hahn et al.	Jul 2013	B2
8650840	Holakovsky et al.	Feb 2014	B2
8651338	Leak et al.	Feb 2014	B2
8656910	Boeck et al.	Feb 2014	B2
8733341	Boeck et al.	May 2014	B2
8734392	Stadelhofer	May 2014	B2
8944292	Moreau	Feb 2015	B2
8950393	Holakovsky et al.	Feb 2015	B2
8960188	Bach et al.	Feb 2015	B2
8997735	Zierenberg et al.	Apr 2015	B2
9027854	Moser et al.	May 2015	B2
9192734	Hausmann et al.	Nov 2015	B2
9238031	Schmelzer et al.	Jan 2016	B2
9744313	Besseler	Aug 2017	B2
9827384	Holakovsky	Nov 2017	B2
10004857	Besseler	Jun 2018	B2
20010008632	Freund et al.	Jul 2001	A1
20010028308	De La Huerga	Oct 2001	A1
20010032643	Hochrainer et al.	Oct 2001	A1
20010035182	Rubin et al.	Nov 2001	A1
20020000225	Schuler et al.	Jan 2002	A1
20020005195	Shick et al.	Jan 2002	A1
20020007155	Freund et al.	Jan 2002	A1
20020046751	MacRae et al.	Apr 2002	A1
20020053344	Davies	May 2002	A1
20020060255	Benoist	May 2002	A1
20020074429	Hettrich et al.	Jun 2002	A1
20020079285	Jansen et al.	Jun 2002	A1
20020092523	Connelly et al.	Jul 2002	A1
20020111363	Drechsel et al.	Aug 2002	A1
20020129812	Litherland et al.	Sep 2002	A1
20020130195	Jaeger	Sep 2002	A1
20020137764	Drechsel et al.	Sep 2002	A1
20020176788	Moutafis et al.	Nov 2002	A1
20030039915	Holt et al.	Feb 2003	A1
20030064032	Lamche et al.	Apr 2003	A1
20030066524	Hochrainer et al.	Apr 2003	A1
20030066815	Lucas	Apr 2003	A1
20030080210	Jaeger	May 2003	A1
20030085254	Katooka et al.	May 2003	A1
20030098023	Drachmann et al.	May 2003	A1
20030106827	Cheu et al.	Jun 2003	A1
20030145849	Drinan et al.	Aug 2003	A1
20030178020	Scarrott	Sep 2003	A1
20030181478	Drechsel et al.	Sep 2003	A1
20030183225	Knudsen	Oct 2003	A1
20030187387	Wirt et al.	Oct 2003	A1
20030191151	Chaudry et al.	Oct 2003	A1
20030194379	Brugger et al.	Oct 2003	A1
20030196660	Haveri	Oct 2003	A1
20030209238	Peters et al.	Nov 2003	A1
20030226907	Geser et al.	Dec 2003	A1
20040004138	Hettrich et al.	Jan 2004	A1
20040010239	Hochrainer et al.	Jan 2004	A1
20040015126	Zierenberg et al.	Jan 2004	A1
20040019073	Drechsel et al.	Jan 2004	A1
20040055907	Marco	Mar 2004	A1
20040060476	Sirejacob	Apr 2004	A1
20040069799	Gee et al.	Apr 2004	A1
20040092428	Chen et al.	May 2004	A1
20040094147	Schyra	May 2004	A1
20040134494	Papania et al.	Jul 2004	A1
20040134824	Chan et al.	Jul 2004	A1
20040139700	Powell et al.	Jul 2004	A1
20040143235	Freund et al.	Jul 2004	A1
20040164186	Kladders	Aug 2004	A1
20040166065	Schmidt	Aug 2004	A1
20040182867	Hochrainer et al.	Sep 2004	A1
20040184994	DeStefano et al.	Sep 2004	A1
20040194524	Jentzsch	Oct 2004	A1
20040210199	Atterbury et al.	Oct 2004	A1
20040231667	Horton et al.	Nov 2004	A1
20050028812	Djupesland	Feb 2005	A1
20050028815	Deaton et al.	Feb 2005	A1
20050028816	Fishman et al.	Feb 2005	A1
20050061314	Davies et al.	Mar 2005	A1
20050089478	Govind et al.	Apr 2005	A1
20050098172	Anderson	May 2005	A1
20050126469	Lu	Jun 2005	A1
20050131357	Denton et al.	Jun 2005	A1
20050158394	Staniforth et al.	Jul 2005	A1
20050159441	Hochrainer et al.	Jul 2005	A1
20050183718	Wuttke et al.	Aug 2005	A1
20050191246	Bechtold-Peters et al.	Sep 2005	A1
20050194472	Geser et al.	Sep 2005	A1
20050239778	Konetzki et al.	Oct 2005	A1
20050247305	Zierenberg et al.	Nov 2005	A1
20050250704	Bassarab et al.	Nov 2005	A1
20050250705	Bassarab et al.	Nov 2005	A1
20050255119	Bassarab et al.	Nov 2005	A1
20050263618	Spallek et al.	Dec 2005	A1
20050268905	Rasmussen	Dec 2005	A1
20050268909	Bonney et al.	Dec 2005	A1
20050268915	Wassenaar et al.	Dec 2005	A1
20050269359	Raats	Dec 2005	A1
20060002863	Schmelzer et al.	Jan 2006	A1
20060016449	Eicher et al.	Jan 2006	A1
20060035874	Lulla et al.	Feb 2006	A1
20060037612	Herder et al.	Feb 2006	A1
20060067952	Chen	Mar 2006	A1
20060086828	Bougamont et al.	Apr 2006	A1
20060150971	Lee et al.	Jul 2006	A1
20060196500	Hochrainer et al.	Sep 2006	A1
20060225734	Sagaser et al.	Oct 2006	A1
20060239886	Nakayama	Oct 2006	A1
20060239930	Lamche et al.	Oct 2006	A1
20060254579	Grychowski et al.	Nov 2006	A1
20060279588	Yearworth et al.	Dec 2006	A1
20060282045	Wilkinson et al.	Dec 2006	A1
20060285987	Jaeger et al.	Dec 2006	A1
20060289002	Hetzer et al.	Dec 2006	A1
20060293293	Muller et al.	Dec 2006	A1
20070062518	Geser	Mar 2007	A1
20070062519	Wuttke et al.	Mar 2007	A1
20070062979	Dunne	Mar 2007	A1
20070090205	Kunze et al.	Apr 2007	A1
20070090576	Geser et al.	Apr 2007	A1
20070107720	Boeck	May 2007	A1
20070119449	Boehm et al.	May 2007	A1
20070137643	Bonney et al.	Jun 2007	A1
20070163574	Rohrschneider et al.	Jul 2007	A1
20070181526	Frishman	Aug 2007	A1
20070183982	Berkel et al.	Aug 2007	A1
20070210121	Stadelhofer et al.	Sep 2007	A1
20070221211	Sagalovich	Sep 2007	A1
20070264437	Zimmermann	Nov 2007	A1
20070272763	Dunne et al.	Nov 2007	A1
20070298116	Bechtold-Peters et al.	Dec 2007	A1
20080017192	Southby et al.	Jan 2008	A1
20080029085	Lawrence et al.	Feb 2008	A1
20080060640	Waldner et al.	Mar 2008	A1
20080083408	Hodson et al.	Apr 2008	A1
20080092885	von Schuckmann	Apr 2008	A1
20080156321	Bowman	Jul 2008	A1
20080163869	Nobutani	Jul 2008	A1
20080164275	Poutiatine	Jul 2008	A1
20080197045	Metzger et al.	Aug 2008	A1
20080249459	Godfrey et al.	Oct 2008	A1
20080264412	Meyer et al.	Oct 2008	A1
20080265198	Warby	Oct 2008	A1
20080283553	Cox et al.	Nov 2008	A1
20080299049	Stangl	Dec 2008	A1
20080308580	Gaydos et al.	Dec 2008	A1
20090032427	Cheu et al.	Feb 2009	A1
20090060764	Mitzlaff et al.	Mar 2009	A1
20090075990	Schmidt	Mar 2009	A1
20090114215	Boeck et al.	May 2009	A1
20090166379	Wright et al.	Jul 2009	A1
20090170839	Schmidt	Jul 2009	A1
20090185983	Freund et al.	Jul 2009	A1
20090197841	Kreher et al.	Aug 2009	A1
20090202447	Kreher et al.	Aug 2009	A1
20090211576	Lehtonen et al.	Aug 2009	A1
20090221626	Schmidt	Sep 2009	A1
20090235924	Holakovsky et al.	Sep 2009	A1
20090272664	Marshall et al.	Nov 2009	A1
20090293870	Brunnberg	Dec 2009	A1
20090306065	Schmidt	Dec 2009	A1
20090308772	Abrams	Dec 2009	A1
20090314287	Spallek et al.	Dec 2009	A1
20090317337	Schmidt	Dec 2009	A1
20100012120	Herder	Jan 2010	A1
20100018524	Jinks et al.	Jan 2010	A1
20100018997	Faneca Llesera	Jan 2010	A1
20100044393	Moretti	Feb 2010	A1
20100056559	Schmelzer et al.	Mar 2010	A1
20100084531	Schuchman	Apr 2010	A1
20100095957	Corbacho	Apr 2010	A1
20100144784	Schmelzer et al.	Jun 2010	A1
20100168710	Braithwaite	Jul 2010	A1
20100237102	Margheritis	Sep 2010	A1
20100242557	Spreitzer et al.	Sep 2010	A1
20100242954	Hahn et al.	Sep 2010	A1
20100313884	Elliman	Dec 2010	A1
20100331765	Sullivan	Dec 2010	A1
20110005517	Boeck et al.	Jan 2011	A1
20110011393	Geser	Jan 2011	A1
20110041842	Bradshaw	Feb 2011	A1
20110168175	Dunne et al.	Jul 2011	A1
20110239594	Nottingham et al.	Oct 2011	A1
20110245780	Helmer et al.	Oct 2011	A1
20110268668	Lamche et al.	Nov 2011	A1
20110277753	Dunne et al.	Nov 2011	A1
20110290239	Bach	Dec 2011	A1
20110290242	Bach et al.	Dec 2011	A1
20110290243	Bach et al.	Dec 2011	A1
20120090603	Dunne et al.	Apr 2012	A1
20120132199	Kiesewetter	May 2012	A1
20120138049	Wachtel	Jun 2012	A1
20120138713	Schuy et al.	Jun 2012	A1
20120260913	Bach et al.	Oct 2012	A1
20120325204	Holakovsky et al.	Dec 2012	A1
20130012908	Yeung	Jan 2013	A1
20130056888	Holakovsky	Mar 2013	A1
20130125880	Holakovsky	May 2013	A1
20130125881	Holakovsky	May 2013	A1
20130126389	Holakovsky et al.	May 2013	A1
20130206136	Herrmann et al.	Aug 2013	A1
20130269687	Besseler et al.	Oct 2013	A1
20140121234	Kreher et al.	May 2014	A1
20140190472	Holakovsky et al.	Jul 2014	A1
20140228397	Schmelzer et al.	Aug 2014	A1
20140331994	Holakovsky et al.	Nov 2014	A1
20150040890	Bessler et al.	Feb 2015	A1
20150040893	Besseler	Feb 2015	A1
20150041558	Bessler et al.	Feb 2015	A1
20150114387	Bach et al.	Apr 2015	A1
20150122247	Besseler et al.	May 2015	A1
20150258021	Kreher et al.	Sep 2015	A1
20150306087	Schmelzer et al.	Oct 2015	A1
20150320947	Eicher et al.	Nov 2015	A1
20150320948	Eicher et al.	Nov 2015	A1
20150352298	Egerstrom	Dec 2015	A1
20160095992	Wachtel	Apr 2016	A1

Foreign Referenced Citations (317)

Number	Date	Country
2005201364	Jul 2006	AU
1094549	Jan 1981	CA
2233981	Apr 1997	CA
2237853	Jun 1997	CA
2251826	Oct 1997	CA
2275392	Jul 1998	CA
2297174	Feb 1999	CA
2343123	Apr 2000	CA
2434872	Aug 2002	CA
2497059	Mar 2004	CA
2497680	Mar 2004	CA
2513167	Oct 2004	CA
2557020	Sep 2005	CA
2653183	Dec 2007	CA
2653422	Dec 2007	CA
1125426	Jun 1996	CN
1849174	Oct 2006	CN
101247897	Aug 2008	CN
1653651	Jul 1971	DE
2754100	Jun 1978	DE
4117078	Nov 1992	DE
19625027	Jan 1997	DE
19615422	Nov 1997	DE
19653969	Jun 1998	DE
1992844	Nov 1999	DE
10007591	Nov 2000	DE
10104367	Aug 2002	DE
10300983	Jul 2004	DE
102004031673	Jan 2006	DE
202006017793	Jan 2007	DE
01102006025871	Dec 2007	DE
83175	Jul 1957	DK
140801	Nov 1979	DK
0018609	Nov 1980	EP
0289332	Nov 1988	EP
0289336	Nov 1988	EP
0354507	Feb 1990	EP
0364235	Apr 1990	EP
0372777	Jun 1990	EP
0386800	Sep 1990	EP
0412524	Feb 1991	EP
0505123	Sep 1992	EP
0520571	Dec 1992	EP
0622311	Nov 1994	EP
0642992	Mar 1995	EP
0679443	Nov 1995	EP
0845265	Jun 1996	EP
0735048	Oct 1996	EP
0811430	Mar 1997	EP
0778221	Jun 1997	EP
0845253	Jun 1998	EP
0860210	Aug 1998	EP
0916428	May 1999	EP
0965355	Dec 1999	EP
0970751	Jan 2000	EP
1003478	May 2000	EP
1017469	Jul 2000	EP
1025923	Aug 2000	EP
1068906	Jan 2001	EP
1075875	Feb 2001	EP
1092447	Apr 2001	EP
1157689	Nov 2001	EP
1211628	Jun 2002	EP
1245244	Oct 2002	EP
1312418	May 2003	EP
1375385	Jan 2004	EP
1521609	Apr 2005	EP
1535643	Jun 2005	EP
1595564	Nov 2005	EP
1595822	Nov 2005	EP
1726324	Nov 2006	EP
1736193	Dec 2006	EP
1795221	Jun 2007	EP
1813548	Aug 2007	EP
2135632	Aug 2007	EP
2614848	Jul 2013	EP
2262348	Nov 2006	ES
2505688	Nov 1982	FR
2604363	Apr 1988	FR
2673608	Sep 1992	FR
2756502	Jun 1998	FR
1524431	Sep 1976	GB
2081396	Feb 1982	GB
2101020	Jan 1983	GB
2279273	Jan 1995	GB
2291135	Jan 1996	GB
2332372	Jun 1999	GB
2333129	Jul 1999	GB
2347870	Sep 2000	GB
2355252	Apr 2001	GB
2398253	Aug 2004	GB
0700839.4	Jul 2008	GB
S5684246	Jul 1981	JP
H01288265	Nov 1989	JP
H0228121	Jan 1990	JP
H057246	Feb 1993	JP
H0553470	Mar 1993	JP
H06312019	Nov 1994	JP
H07118164	May 1995	JP
H07118166	May 1995	JP
07323086	Dec 1995	JP
H08277226	Oct 1996	JP
H092442	Jan 1997	JP
H0977073	Mar 1997	JP
H09315953	Dec 1997	JP
2001518428	Oct 2001	JP
2001346878	Dec 2001	JP
2002504411	Feb 2002	JP
2002235940	Aug 2002	JP
2003511212	Mar 2003	JP
2003299717	Oct 2003	JP
2004502502	Jan 2004	JP
2004097617	Apr 2004	JP
2005511210	Apr 2005	JP
2005144459	Jun 2005	JP
2006505374	Feb 2006	JP
2007517529	Jul 2007	JP
2007245144	Sep 2007	JP
2007534379	Nov 2007	JP
2008119489	May 2008	JP
2008541806	Nov 2008	JP
2010526620	Aug 2010	JP
2010540371	Dec 2010	JP
198100674	Mar 1981	WO
198200785	Mar 1982	WO
198300288	Feb 1983	WO
198303054	Sep 1983	WO
198605419	Sep 1986	WO
198706137	Oct 1987	WO
198803419	May 1988	WO
198900889	Feb 1989	WO
198900947	Feb 1989	WO
198902279	Mar 1989	WO
198903672	May 1989	WO
198903673	May 1989	WO
198905139	Jun 1989	WO
199009780	Sep 1990	WO
199009781	Sep 1990	WO
1991014468	Oct 1991	WO
199206704	Apr 1992	WO
199217231	Oct 1992	WO
199221332	Dec 1992	WO
199222286	Dec 1992	WO
1993013737	Jul 1993	WO
199325321	Dec 1993	WO
1993024164	Dec 1993	WO
1994007607	Apr 1994	WO
199417822	Aug 1994	WO
199425371	Nov 1994	WO
199427653	Dec 1994	WO
199503034	Feb 1995	WO
1995032015	Nov 1995	WO
199600050	Jan 1996	WO
1996006011	Feb 1996	WO
199606581	Mar 1996	WO
199623522	Aug 1996	WO
199701329	Jan 1997	WO
199706813	Feb 1997	WO
199706842	Feb 1997	WO
199712683	Apr 1997	WO
1997012687	Apr 1997	WO
199720590	Jun 1997	WO
199723208	Jul 1997	WO
199727804	Aug 1997	WO
199735562	Oct 1997	WO
199741833	Nov 1997	WO
1998012511	Mar 1998	WO
199827959	Jul 1998	WO
199831346	Jul 1998	WO
199839043	Sep 1998	WO
1999001227	Jan 1999	WO
1999007340	Feb 1999	WO
1999011563	Mar 1999	WO
1999016530	Apr 1999	WO
1999043571	Sep 1999	WO
19965464	Dec 1999	WO
199962495	Dec 1999	WO
200001612	Jan 2000	WO
200023037	Apr 2000	WO
2000023065	Apr 2000	WO
200027543	May 2000	WO
200037336	Jun 2000	WO
2000033965	Jun 2000	WO
200049988	Aug 2000	WO
200064779	Nov 2000	WO
200113885	Mar 2001	WO
200128489	Apr 2001	WO
2001064182	Sep 2001	WO
200187392	Nov 2001	WO
2001085097	Nov 2001	WO
200197888	Dec 2001	WO
200198175	Dec 2001	WO
200198176	Dec 2001	WO
200204054	Jan 2002	WO
200205879	Jan 2002	WO
200217988	Mar 2002	WO
200232899	Apr 2002	WO
2002034411	May 2002	WO
2002070141	Sep 2002	WO
2002089887	Nov 2002	WO
2003002045	Jan 2003	WO
2003014832	Feb 2003	WO
2003020253	Mar 2003	WO
2003022332	Mar 2003	WO
200307159	May 2003	WO
2003035030	May 2003	WO
2003037259	May 2003	WO
2003049786	Jun 2003	WO
2003050031	Jun 2003	WO
2003053350	Jul 2003	WO
2003057593	Jul 2003	WO
2003059547	Jul 2003	WO
2003068299	Aug 2003	WO
2003087097	Oct 2003	WO
2003097139	Nov 2003	WO
2004019985	Mar 2004	WO
2004022052	Mar 2004	WO
2004022132	Mar 2004	WO
2004022244	Mar 2004	WO
2004024157	Mar 2004	WO
200433954	Apr 2004	WO
2004041334	May 2004	WO
2004062813	Jul 2004	WO
2004078236	Sep 2004	WO
2004089551	Oct 2004	WO
2004091704	Oct 2004	WO
2004098689	Nov 2004	WO
2004098795	Nov 2004	WO
2005000476	Jan 2005	WO
2005004844	Jan 2005	WO
2005014175	Feb 2005	WO
2005020953	Mar 2005	WO
2005030211	Apr 2005	WO
2005055976	Jun 2005	WO
2005077445	Aug 2005	WO
2005079997	Sep 2005	WO
2005080001	Sep 2005	WO
2005080002	Sep 2005	WO
2005087299	Sep 2005	WO
2005107837	Nov 2005	WO
2005109948	Nov 2005	WO
2005112892	Dec 2005	WO
2005112996	Dec 2005	WO
2005113007	Dec 2005	WO
2006011638	Feb 2006	WO
2006018392	Feb 2006	WO
2006027595	Mar 2006	WO
2006037636	Apr 2006	WO
2006037948	Apr 2006	WO
2006042297	Apr 2006	WO
2006045813	May 2006	WO
2006110080	Oct 2006	WO
2006125577	Nov 2006	WO
2006126014	Nov 2006	WO
2007011475	Jan 2007	WO
2007022898	Mar 2007	WO
2007030162	Mar 2007	WO
2007049239	May 2007	WO
2007060104	May 2007	WO
2007060105	May 2007	WO
2007060106	May 2007	WO
2007060107	May 2007	WO
2007060108	May 2007	WO
2007062721	Jun 2007	WO
2007090822	Aug 2007	WO
2007101557	Sep 2007	WO
2007128381	Nov 2007	WO
2007134965	Nov 2007	WO
2007134966	Nov 2007	WO
2007134967	Nov 2007	WO
2007134968	Nov 2007	WO
2007141201	Dec 2007	WO
2007141203	Dec 2007	WO
2008023017	Feb 2008	WO
2008047035	Apr 2008	WO
2008077623	Jul 2008	WO
2008124666	Oct 2008	WO
2008138936	Nov 2008	WO
2008146025	Dec 2008	WO
2009006137	Jan 2009	WO
2009047021	Apr 2009	WO
2009047173	Apr 2009	WO
2009050978	Apr 2009	WO
2009090245	Jul 2009	WO
2009103510	Aug 2009	WO
2009115200	Sep 2009	WO
2010005946	Jan 2010	WO
2010006870	Jan 2010	WO
2010094305	Aug 2010	WO
2010094413	Aug 2010	WO
2010112358	Oct 2010	WO
2010133294	Nov 2010	WO
2010149280	Dec 2010	WO
2011006711	Jan 2011	WO
2011064160	Jun 2011	WO
2011064163	Jun 2011	WO
2011064164	Jun 2011	WO
2011131779	Oct 2011	WO
2011154295	Dec 2011	WO
2011160932	Dec 2011	WO
2012130757	Oct 2012	WO
2012159914	Nov 2012	WO
2012160047	Nov 2012	WO
2012160052	Nov 2012	WO
2012161685	Nov 2012	WO
2012162305	Nov 2012	WO
2013107640	Jul 2013	WO
2013110601	Aug 2013	WO
2013152861	Oct 2013	WO
2013152894	Oct 2013	WO
2014111370	Jul 2014	WO
2015018901	Feb 2015	WO
2015018903	Feb 2015	WO
2015018904	Feb 2015	WO
2015169431	Nov 2015	WO
2015169732	Nov 2015	WO
199901520	Dec 1999	ZA

Non-Patent Literature Citations (92)

Entry
International Search Report and Written Opinion for PCT/EP04006768, 10 pages, dated Sep. 24, 2004.
International Search Report and Written Opinion for PCT/EP2005/001947, 11 pages, dated May 19, 2005.
International Search Report and Written Opinion for PCT/EP2005/004792, 19 pages, dated Aug. 4, 201.
International Search Report and Written Opinion for PCT/EP2005/055560, 13 pages, dated Mar. 2, 2006.
International Search Report and Written Opinion for PCT/EP2006/068399, 8 pages, dated on Jun. 25, 2007.
International Search Report and Written Opinion for PCT/EP2006/068395, 8 pages, dated Jun. 25, 2007.
International Search Report and Written Opinion for PCT/EP2006/068396, 11 pages, dated Apr. 23, 2007.
International Search Report and Written Opinion for PCT/EP2006/068397, 13 pages, dated Feb. 21, 2007.
International Search Report and Written Opinion for PCT/EP2006/068398, 10 pages, dated May 10, 2007.
International Search Report and Written Opinion for PCT/EP2007/001558, 13 pages, dated Sep. 28, 2007.
International Search Report and Written Opinion for PCT/EP2007/054488, 11 pages, dated Jul. 18, 2007.
International Search Report and Written Opinion for PCT/EP2007/054490, 11 pages, dated Jul. 17, 2007.
International Search Report and Written Opinion for PCT/EP2007/054492, 13 pages, dated Aug. 16, 2007.
International Search Report and Written Opinion for PCT/EP2007/055381, 14 pages, dated Sep. 3, 2007.
International Search Report and Written Opinion for PCT/EP2007/055383, 18 pages, dated Sep. 27, 2007.
International Search Report and Written Opinion for PCT/EP2009/001619, 6 pages, dated Jun. 10, 2009.
International Search Report and Written Opinion for PCT/EP2009/005949, 8 pages, dated Jan. 20, 2010.
International Search Report and Written Opinion for PCT/EP2010/057937, 1 pages, dated Jul. 20, 2010.
International Search Report and Written Opinion for PCT/EP2010/067896, 14 pages, dated Apr. 13, 2011.
International Search Report and Written Opinion for PCT/EP2010/067901, 12 pages, dated Apr. 14, 2011.
International Search Report and Written Opinion for PCT/EP2010/067902, 10 pages, dated May 2, 2011.
International Search Report and Written Opinion for PCT/EP2012/058905, 12 pages, dated Oct. 19, 2012.
International Search Report and Written Opinion for PCT/EP2012/059454, 16 pages, dated Jan. 14, 2013.
International Search Report and Written Opinion for PCT/EP2012/059463, 10 pages, dated Oct. 25, 2012.
International Search Report and Written Opinion for PCT/EP2013/001068, 9 pages, dated Jun. 5, 2013.
International Search Report and Written Opinion for PCT/EP2013/054324, 11 pages, dated Jun. 5, 2013.
International Search Report and Written Opinion for PCT/EP2014/067006, 15 pages, dated Nov. 24, 2014.
International Search Report and Written Opinion for PCT/EP2015/000903, 31 pages, dated Nov. 5, 2015.
International Search Report and Written Opinion for PCT/EP2015/059691, 22 pages, dated Oct. 8, 2015.
International Search Report and Written Opinion for corresponding PCT/EP2010/007961, 18 pages, dated Oct. 28, 2010.
International Search Report for PCT/EP199904803, 6 pages, dated Dec. 15, 1998.
International Search Report for PCT/EP1999/07589, 6 pages, dated Mar. 1, 2000.
International Search Report and Written Opinion for PCT/EP2007/003322, 13 pages, dated Aug. 17, 200.
International Search Report and Written Opinion for PCT/EP2007/054489, 12 pages, dated Feb. 10, 2007.
International Search Report and Written Opinion for PCT/EP2008/011112, 14 pages, dated Sep. 3, 2009.
International Search Report and Written Opinion for PCT/EP2008/055863, 25 pages, dated Dec. 19, 2008.
International Search Report and Written Opinion for PCT/EP2009/001153, 8 pages, dated May 20, 2009.
International Search Report and Written Opinion for PCT/EP2010/002740, 18 pages, dated Nov. 12, 2010.
International Search Report and Written Opinion for PCT/EP2010/053668, 11 pages, dated Nov. 8, 2010.
International Search Report and Written Opinion for PCT/EP2011/059088, 14 pages, dated Sep. 26, 2011.
International Search Report and Written Opinion for PCT/EP2012/055209, 10 pages, dated Jan. 6, 2012.
International Search Report and Written Opinion for PCT/EP2007/051095, 10 pages, dated Sep. 21, 2007.
Wall et al., “High levels of exopeptidase activity are present in rat and anine bronchoalveolar lavage fluid,” International Journal of Pharmaceutics, vol. 97, Issue 1-3, pp. 171-181, (Jan. 1993).
International Search Report and Written Opinion for PCT/EP2014/067001 dated Sep. 9, 2014.
International Search Report and Written Opinion for PCT/EP2014/067004 dated Jan. 10, 2014.
“Activate”. Collins English Dictionary, London; Collins, 2000, 2 pages. [Retrieved at http://search.credoreference.com/content/entry/hcengdict/activate/0 on Jun. 12, 2014].
“Lung Cancer”. Merck Manual Home Edition, pp. 1-7. [Accessed at www.merck.com/mmhe/print/sec04/ch057/ch057a.html, on Jul. 28, 2010].
Abstract in English for DE19902844, 1999.
Abstract in English for DE4117078, 1992.
Abstract in English for EP0354507, 1990.
Abstract in English for FR2756502, 1998.
Abstract in English for JPS5684246, 1979.
Abstract in English of DE10007591, 2000.
Abstract in English of DE202006017793, 2007.
Abstract in English of FR2604363, Sep. 30, 1986.
Abstract in English of JPH0553470, 1993.
Abstract in English of JPH057246, 1993.
Abstract in English of JPH07118164, 1995.
Abstract in English of JPH07118166, 1995.
Abstract in English of JPH08277226,1996.
Abstract in English of JPH092442, 1997.
Abstract in English of JPH09315953, 1997.
Abstract in English of JPH0977073, 1997.
Abstract in English of WO199706813, 1997.
Abstract in English of WO199839043, 1998.
Abstract in English of WO2002070141, 2002.
Ackermann et al.; Quantitative Online Detection of Low-Concentrted Drugs via a SERS Microfluidic System; ChemPhysChem; 2007; vol. 8; pp. 2665-2670.
Beasley R et al: “Preservatives in Nebulizer solutions; Risks without Benefit” Pharmacotherapy, Boston, US, Bd. 18, Nr 1, Jan. 1998.
Beasley R et al: “Preservatives in Nebulizer solutions: Risks without Benefit” Pharmacotherapy, Boston, US, Bd. 18, Nr. 1, Jan. 1998, pp. 130-139.
Bocci et al., “Pulmonary catabolism of interferons: alveolar absorption of 125l-labeled human interferon alpha is accompanied by partial loss of biologicall activity” Antiviral Research, vol. 4, 1984, pp. 211-220.
Chen, F-K et al., “A study of forming pressure in the tube-hydroforming process”, Journal of Materials Processing Technology, 192-193, 2007, p. 404-409.
China Suppliers, Shanghai Life Chemical Technology Co., Ltd. Product details on polyvinylpyrrolidones. Obtained online by the USPTO examiner on Apr. 24, 2011.
Cras et al., “Comparison of chemical cleaning methods of glass in preparation for silanization”. Biosensors & Bioelectronics, vol. 14, 1999, pp. 683-688.
Diamond et al., “Substance P Fails to Mimic Vagally Mediated Nonadrenergic Bronchodilation”. Peptides, vol. 3, 1982, pp. 27-29.
Elwenspoek et al., “Silicon Micromachining”, Chapter 3, Mechanical Microsensors, Springer-Verlang Berlin Heidelberg, 2001, 4 pages.
English Language Abstract of EP1068906, 2001.
Fuchs et al., “Meopterin, biochemistry and clinical use as a marker for cellular immune reactions”. International Archives of Allergy and Immunology, vol. 101, No. 1, 1993, pp. 1-6, Abstract 1p.
Han et al.; Surface activation of thin silicon oxides by wet cleaninig and silanization; This Solid Films; 2006; vol. 510; No. 1-2; pp. 175-180.
Henkel et al.; Chip modules for generation and manipulation of fluid segments for micro serial flow processes; Chemical Engineering Journal; 2004; vol. 101; pp. 439-445.
Hoffmann et al., “Mixed self-assembled monolayers (SAMs) consisting of methoxy-tri(ethylene glycol)-terminated and alkyl-terminated dimethylchlorosilanes control the non-specific adsorption of proteins at oxidic sufaces”. Journal of Colloid and Interface Science, vol. 295, 2006, pp. 427-435.
Husseini et al., “Alkyl Monolayers on Silica Surfaces Prepaid Using Neat, Heated Dimethylmonochlorosilanes with Low Vapor Pressures”. Langmuir, vol. 19, 2003, pp. 5169-5171.
Ip et al., “Stability of Recombinant Consensus Interferon to Air-Jest and Ultrasonic Nebulization”. Journal of Pharmaceutical Sciences, vol. 84, No. 10, Oct. 1995, pp. 1210-1214.
Jendle et al., “Intrapulmonary administration of insulin to healthy volunteers”. Journal of Internal Medicine, vol. 240, 1996, pp. 93-98.
JP2005144459—English language abstract only.
Kutchoukov et al., “Fabrication of nanofluidic devices using glass-to-glass anodic bonding” Sensors and Actuators A, vol. 114, 2004, pp. 521-527.
Lougheed et al., “Insulin Aggregation in Artificial Delivery Systems”. Diabetologia, vol. 19, 1980, pp. 1-9.
Mandal et al., “Cytophobic surface modification of microfluidic arrays for in situ parallel peptide synthesis and cell adhesion assays”. Biotechnology Progress, vol. 23, No. 4, 2007, pp. 972-978 (Author Manuscript Available in PMC, Sep. 21, 2009, 19 pages).
Niven et al., “Some Factors Associated with the Ultrasonic Nebulization of Proteins”. Pharmaceutical Research, vol. 12, No. 1, 1995, pp. 53-59.
Remington Pharmacy, Editor Alfonso R. Gennaro. 19th ed., Spanish Secondary Edition: Panamericana, Spain, 1995, Sciarra, J.J., “Aerosols”, pp. 2560-2582. The English translation is from the 1995 English Primary Edition, Sciarra, J.J. , Chapter 95, R97-1185.
Trasch et al., “Performance data of refloquart Glucose in the Evaluation of Reflotron”. Clinical Chemistry, vol. 30, 1984, p. 969 (abstract only).
Wall et al., “High levels of exopeptidase activity are present in rat canine bronchoalyeolar lavage fluid”, International Journall of Pharmaceutics, vol. 97, Issue 1-3, pp. 171-181. 1993, Abstract pp. 1-2.
Wang et al.; Self-Assembled Silane Monolayers; Fabrication with Nanoscale Uniformity; Langmuir, 2005; vol. 21, No. 5; pp. 1846-1857.

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	20210093807 A1	Apr 2021	US

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	Number	Date	Country
Parent	15942737	Apr 2018	US
Child	17122043		US
Parent	14453805	Aug 2014	US
Child	15942737		US

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