Novel human polynucleotides and polypeptides encoded thereby

Abstract

The present invention provides ORFX, a novel isolated polypeptide, as well as a polynucleotide encoding ORFX and antibodies that immunospecifically bind to ORFX or any derivative, variant, mutant, or fragment of the ORFX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the ORFX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to others uses.

Description

BACKGROUND OF THE INVENTION

[0002] The invention relates generally to nucleic acids and polypeptides encoded thereby, and methods of using these nucleic acids and polypeptides.

SUMMARY OF THE INVENTION

[0003] The invention is based in part on the discovery of nucleic acids that include open reading frames encoding novel polypeptides, and on the polypeptides encoded thereby. The nucleic acids and polypeptides are collectively referred to herein as “ORFX”.

[0004] Accordingly, in one aspect, the invention provides an isolated nucleic acid molecule (SEQ ID NO:2n−1, wherein n is an integer between 1-4534), that encodes novel polypeptide, or a fragment, homolog, analog or derivative thereof. The nucleic acid can include, e.g., a nucleic acid sequence encoding a polypeptide at least 85% identical to a polypeptide comprising the amino acid sequences of SEQ ID NO:2n, wherein n is an integer between 1-4534. The nucleic acid can be, e.g., a genomic DNA fragment, or a cDNA molecule.

[0005] Also included in the invention is a vector containing one or more of the nucleic acids described herein, and a cell containing the vectors or nucleic acids described herein.

[0006] The invention is also directed to host cells transformed with a recombinant expression vector comprising any of the nucleic acid molecules described above.

[0007] In another aspect, the invention includes a pharmaceutical composition that includes an ORFX nucleic acid and a pharmaceutically acceptable carrier or diluent.

[0008] In a further aspect, the invention includes a substantially purified ORF polypeptide, e.g., any of the ORFX polypeptides encoded by an ORFX nucleic acid, and fragments, homologs, analogs, and derivatives thereof. The invention also includes a pharmaceutical composition that includes a ORFX polypeptide and a pharmaceutically acceptable carrier or diluent.

[0009] In a still a further aspect, the invention provides an antibody that binds specifically to an ORFX polypeptide. The antibody can be, e.g., a monoclonal or polyclonal antibody, and fragments, homologs, analogs, and derivatives thereof. The invention also includes a pharmaceutical composition including ORFX antibody and a pharmaceutically acceptable carrier or diluent. The invention is also directed to isolated antibodies that bind to an epitope on a polypeptide encoded by any of the nucleic acid molecules described above.

[0010] The invention also includes kits comprising any of the pharmaceutical compositions described above.

[0011] The invention further provides a method for producing an ORFX polypeptide by providing a cell containing a ORFX nucleic acid, e.g., a vector that includes a ORFX nucleic acid, and culturing the cell under conditions sufficient to express the ORFX polypeptide encoded by the nucleic acid. The expressed ORFX polypeptide is then recovered from the cell. Preferably, the cell produces little or no endogenous ORFX polypeptide. The cell can be, e.g., a prokaryotic cell or eukaryotic cell.

[0012] The invention is also directed to methods of identifying an ORFX polypeptide or nucleic acids in a sample by contacting the sample with a compound that specifically binds to the polypeptide or nucleic acid, and detecting complex formation, if present.

[0013] The invention further provides methods of identifying a compound that modulates the activity of a ORFX polypeptide by contacting ORFX polypeptide with a compound and determining whether the ORFX polypeptide activity is modified.

[0014] The invention is also directed to compounds that modulate ORFX polypeptide activity identified by contacting a ORFX polypeptide with the compound and determining whether the compound modifies activity of the ORFX polypeptide, binds to the ORFX polypeptide, or binds to a nucleic acid molecule encoding a ORFX polypeptide.

[0015] In a another aspect, the invention provides a method of determining the presence of or predisposition of an ORFX-associated disorder in a subject. The method includes providing a sample from the subject and measuring the amount of ORFX polypeptide in the subject sample. The amount of ORFX polypeptide in the subject sample is then compared to the amount of ORFX polypeptide in a control sample. An alteration in the amount of ORFX polypeptide in the subject protein sample relative to the amount of ORFX polypeptide in the control protein sample indicates the subject has a tissue proliferation-associated condition. A control sample is preferably taken from a matched individual, i.e., an individual of similar age, sex, or other general condition but who is not suspected of having a tissue proliferation-associated condition. Alternatively, the control sample may be taken from the subject at a time when the subject is not suspected of having a tissue proliferation-associated disorder. In some embodiments, the ORFX is detected using a ORFX antibody.

[0016] In a further aspect, the invention provides a method of determining the presence of or predisposition of an ORFX-associated disorder in a subject. The method includes providing a nucleic acid sample, e.g., RNA or DNA, or both, from the subject and measuring the amount of the ORFX nucleic acid in the subject nucleic acid sample. The amount of ORFX nucleic acid sample in the subject nucleic acid is then compared to the amount of an ORFX nucleic acid in a control sample. An alteration in the amount of ORFX nucleic acid in the sample relative to the amount of ORFX in the control sample indicates the subject has a tissue proliferation-associated disorder.

[0017] In a still further aspect, the invention provides a method of treating or preventing or delaying a ORFX-associated disorder. The method includes administering to a subject in which such treatment or prevention or delay is desired a ORFX nucleic acid, a ORFX polypeptide, or an ORFX antibody in an amount sufficient to treat, prevent, or delay a tissue proliferation-associated disorder in the subject.

[0018] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In the case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting. Other features and advantages of the invention will be apparent from the following detailed description and claims.

DETAILED DESCRIPTION OF THE INVENTION

[0019] The invention provides novel polypeptides and nucleotides encoded thereby. The polynucleotides and their encoded polypeptides can be grouped according to the functions played by their gene products. Such functions include, structural proteins, proteins from which associated with metabolic pathways fatty acid metabolism, glycolysis, intermediary metabolism, calcium metabolism, proteases, and amino acid metabolism, etc.

[0020] Included in the invention are 4534 novel nucleic acid sequences and their encoded polypeptides. The sequences are collectively referred to as “ORFX nucleic acids” or ORFX polynucleotides” and the corresponding encoded polypeptides are referred to as “ORFX polypeptides” or ORFX proteins”. The ORFX polynucleotides and the encoded polypeptides are

[0021] To determine similarity to previously described proteins, polypeptides encoded by ORFX DNA sequences were tested using the Framesearch Algorithm against a nonredundant version of the GenPept Database from NCBI/Genbank. DNA sequences that had a score of ‘90’ or above (Framesearch algorithm score, Edelman et. al. GCG Genetics) to a known protein were selected. Open reading frames were extended beyond the region of the protein matched using standard DNA translation and codon tables. Novel proteins that lacked a protein match were translated against the standard genetic codons and proteins with an ORF at least 80 amino acids and containing a Methionine start are included in the Table.

[0022] Column 4 of Table 1, entitled “Protein Domain”, lists previously described protein domains, designated by pfam entries, that are present in the polypeptides encoded by the ORFs, Also included in column 3 are proteins in which these domains are present. The pfam entries can be retrieved from http://pfam.wustl.edu/. DNA sequences were translated in all six frames and tested using the Hmmer Algorithm against the Pfam Database (References to the algorithm and Pfam database can be found at http://pfam.wustl.edu). Translated DNA sequences that matched a protein domain entry in the Pfam database AND had a score of ‘7.5’ were selected.

[0023] Column 5 of Table 3, entitled “Protein Classification”, lists the classification assigned for the protein, based on its homology. Examples of proteins in the classification include the following:

[0024] Amylases

[0025] Amylase is responsible for endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides. Variations in amylase gene may be indicative of delayed maturation and of various amylase producing neoplasms and carcinomas.

[0026] Amyloid

[0027] The serum amyloid A (SAA) proteins comprise a family of vertebrate proteins that associate predominantly with high density lipoproteins (HDL). The synthesis of certain members of the family is greatly increased in inflammation. Prolonged elevation of plasma SAA levels, as in chronic inflammation, 15 results in a pathological condition, called amyloidosis, which affects the liver, kidney and spleen and which is characterized by the highly insoluble accumulation of SAA in these tissues. Amyloid selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Deposition of fibrillar amyloid proteins intraneuronally, as neurofibrillary tangles, extracellularly, as plaques and in blood vessels, is characteristic of both Alzheimer's disease and aged Down's syndrome. Amyloid deposition is also associated with type II diabetes mellitus.

[0028] Angiopoeitin

[0029] Members of the angiopoeitin/fibrinogen family have been shown to stimulate the generation of new blood vessels, inhibit the generation of new blood vessels, and perform several roles in blood clotting. This generation of new blood vessels, called angiogenesis, is also an essential step in tumor growth in order for the tumor to get the blood supply it needs to expand. Variation in these genes may be predictive of any form of heart disease, numerous blood clotting disorders, stroke, hypertension and predisposition to tumor formation and metastasis. In particular, these variants may be predictive of the response to various antihypertensive drugs and chemotherapeutic and anti-tumor agents.

[0030] Apoptosis-related Proteins

[0031] Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins. It is controlled by regulators, which have either an inhibitory effect on programmed cell death (anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic). Many viruses have found a way of countering defensive apoptosis by encoding their own anti-apoptosis genes preventing their target-cells from dying too soon. Variants of apoptosis related genes may be useful in formulation of anti-aging drugs.

[0032] Cadherin, Cyclin, Polymerase, Oncogenes, Histones, Kinases

[0033] Members of the cell division/cell cycle pathways such as cyclins, many transcription factors and kinases, DNA polymerases, histones, helicases and other oncogenes play a critical role in carcinogenesis where the uncontrolled proliferation of cells leads to tumor formation and eventually metastasis. Variation in these genes may be predictive of predisposition to any form of cancer, from increased risk of tumor formation to increased rate of metastasis. In particular, these variants may be predictive of the response to various chemotherapeutic and anti-tumor agents.

[0034] Colony-stimulating Factor-related Proteins

[0035] (Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.

[0036] Complement-related Proteins

[0037] Complement proteins are immune associated cytotoxic agents, acting in a chain reaction to exterminate target cells to that were opsonized (primed) with antibodies, by forming a membrane attack complex (MAC). The mechanism of killing is by opening pores in the target cell membrane. Variations in 20 complement genes or their inhibitors are associated with many autoimmune disorders. Modified serum levels of complement products cause edemas of various tissues, lupus (SLE), vasculitis, glomerulonephritis, renal failure, hemolytic anemia, thrombocytopenia, and arthritis. They interfere with mechanisms of ADCC (antibody dependent cell cytotoxicity), severely impair immune competence and reduce phagocytic ability. Variants of complement genes may also be indicative of type I diabetes mellitus, meningitis neurological disorders such as nemaline myopathy, neonatal hypotonia, muscular disorders such as congenital myopathy and other diseases.

[0038] Cytochrome

[0039] The respiratory chain is a key biochemical pathway which is essential to all aerobic cells. There are five different cytochromes involved in the chain. These are heme bound proteins which serve as electron carriers. Modifications in these genes may be predictive of ataxia areflexia, dementia and myopathic and neuropathic changes in muscles. Also, association with various types of solid tumors.

[0040] Kinesins

[0041] Kinesins are tubulin molecular motors that function to transport organelles within cells and to move chromosomes along microtubules during cell division. Modifications of these genes may be indicative of neurological disorders such as Pick disease of the brain, tuberous sclerosis.

[0042] Cytokines, Interferon, Interleukin

[0043] Members of the cytokine families are known for their potent ability to stimulate cell growth and division even at low concentrations. Cytokines such as erythropoietin are cell-specific in their growth stimulation; erythropoietin is useful for the stimulation of the proliferation of erythroblasts. Variants in cytokines may be predictive for a wide variety of diseases, including cancer predisposition.

[0044] G-protein Coupled Receptors

[0045] G-protein coupled receptors (also called R7G) are an extensive group of hormones, neurotransmitters, odorants and light receptors which transduce extracellular signals by interaction with guanine nucleotide-binding (G) proteins. Alterations in genes coding for G-coupled proteins may be involved in and indicative of a vast number of physiological conditions. These include blood pressure regulation, renal dysfunctions, male infertility, dopamine associated cognitive, emotional, and endocrine functions, hypercalcemia, chondrodysplasia and osteoporosis, pseudohypoparathyroidism, growth retardation and dwarfism.

[0046] Thioesterases

[0047] Eukaryotic thiol proteases are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad. Variants of thioester associated genes may be predictive of neuronal disorders and mental illnesses such as Ceroid Lipoffiscinosis, Neuronal 1, Infantile, Santavuori disease and more.

[0048] The key to the molecule type is as follows:

Abbrev:            Title:
amylase            amylase protein
amylaseinhib       amylase inhibitor
amyloid            amyloid protein
apoptosis          apoptosis associated protein
apoptosisinhib     apoptosis inhibitors
apoptosisrecep     apoptosis receptors
ATPase_associated  ATPase associated protein
biotindep          biotin dependent enzyme/protein
cadherin           cadherin protein
calcium_channel    calcium channel protein
carboxylase        carboxylase protein
cathepsin          cathepsin/carboxypeptidases
cathepsininhib     cathepsin/carboxypeptidase inhibitor
chloride_channel   chloride channel protein
collagen           collagen
complement         complement protein
complementrecept   complement receptor protein
complementinhib    complement inhibitor
csf                colony stimulating factor
csfrecept          colony stimulating factor receptor
cyclin             cyclin protein
cyto450            cytochrome p450 protein
cytochrome         cytochrome related protein
deaminase          deaminase
dehydrogenase      dehydrogenase
desaturase         desaturase
dna_rna_bind       DNA/RNA binding protein/factor
dna_rna_inhib      DNA/RNA binding protein/factor inhibitor
dynein             dynein
elastase           elastase
elastaseinhib      elastase inhibitor
eph                EPH family of tyrosine kinases
esterase           esterase
esteraseinhib      esterase inhibitor
fgf                fibroblast growth factor
fgfreceptor        fibroblast growth factor receptor
gaba               GABA receptor
glucoamylase       glucoamylase
glucoronidase      glucoronidase
glycoprotein       glycoprotein
Guanylyl           guanylylate cyclase
helicase           helicase
histone            histone
HOM                homologous
homeobox           homeobox protein
hydrolase          hydrolase
hydroxysteroid     hydroxysteroid associated protein
hypoxanthine       hypoxanthine associated protein
immunoglob         immunoglobulin
immunoglobrecept   immunoglobulin receptor
interferon         interferon
interleukin        interleukin
interleukinrecept  interleukin receptor
isomerase          isomerase
isomeraseinhibitor isomerase inhibitor
isomerasereceptor  isomerase receptor
kinase             kinase
kinaseinhibitor    kinase inhibitor
kinasereceptor     kinase receptor
kinesin            kinesin
laminin            laminin associated protein
lipase             lipase
metallothionein    metallothionein
MHC                major histocompatability complex
misc_channel       miscellaneous channel
ngf                nerve growth factor
nuci_recpt         nuclear receptor
nuclease           nuclease
oncogene           oncogene associated protein
oxidase            oxidase
oxygenase          oxygenase
peptidase          peptidase
peroxidase         peroxidase
phosphatase        phosphatase
phosphataseinhib   phosphatase inhibitor
phosphorylase      phosphorylase
PIR                PIR DATABASE (release 56,
                   29 OCT. 1998)
polymerase         polymerase
potassium_channel  potassium channel protein
prostaglandin      prostaglandin
protease           protease
proteaseinhib      protease inhibitor
reductase          reductase
ribosomalprot      ribosomal associated protein
RTR                EMBLDATABASE translated entries not to
                   be incorporated into SWISS-PROT
                   (20 JUL. 1998)
SIM                similar
SPTR               EMBL DATABASE translated entries to be
                   incorporated into SWISS-PROT
                   (20 JUL. 1998)
struct             structural associated protein
sulfotransferase   sulfotransferase
SWP                SWISS-PROT DATABASE
                   (release 18 OCT. 1998)
SWPN               SWISS-PROT Update
                   (release 11 NOV. 1998)
synthase           synthase
tgf                transforming growth factor
tgfreceptor        transforming growth factor receptor
thioesterase       thioesterase
thiolase           thiolase
tm7                seven transmembrane domain G-protein
                   coupled receptor
tnf                necrosis factor receptor
traffic            tumor necrosis factor
tnfreceptor        tumor trafficking associated protein
TRN                EMBL DATABASE translated entries
                   update (20 JUL. 1998)
transcriptfactor   transcription factor
transferase        transferase
transport          transport protein
tubulin            tubulin
ubiquitin          ubiquitin
unclassified       Protein not categorized into one of the
                   aforementioned protein families
water channel      water channel protein

[0049] from the disclosed sequence while still encoding a protein that maintains its ORFX-like activities and physiological functions. The invention further includes the complement of the nucleic acid sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), including fragments, derivatives, analogs and homolog thereof. The invention additionally includes nucleic acids or nucleic acid fragments, or complements thereto, whose structures include chemical modifications.

[0050] Also included are nucleic acid fragments sufficient for use as hybridization probes to identify ORFX-encoding nucleic acids (e.g., ORFX mRNA) and fragments for use as polymerase chain reaction (PCR) primers for the amplification or mutation of ORFX nucleic acid molecules. As used herein, the term “nucleic acid molecule” is intended to include DNA molecules (e.g, cDNA or genomic DNA), RNA molecules (e.g., mRNA), analogs of the DNA or RNA generated using nucleotide analogs, and derivatives, fragments and homologs thereof. The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA.

[0051] “Probes” refer to nucleic acid sequences of variable length, preferably between at least about 10 nucleotides (nt), 100 nt, or as many as about, e.g., 6,000 nt, depending on use. Probes are used in the detection of identical, similar, or complementary nucleic acid sequences. Longer length probes are usually obtained from a natural or recombinant source, are highly specific and much slower to hybridize than oligomers. Probes may be single- or double-stranded and designed to have specificity in PCR, membrane-based hybridization technologies, or ELISA-like technologies.

[0052] An “isolated” nucleic acid molecule is one that is separated from other nucleic acid molecules that are present in the natural source of the nucleic acid. Examples of isolated nucleic acid molecules include, but are not limited to, recombinant DNA molecules contained in a vector, recombinant DNA molecules maintained in a heterologous host cell, partially or substantially purified nucleic acid molecules, and synthetic DNA or RNA molecules. Preferably, an “isolated” nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated ORFX nucleic acid molecule can contain less than about 50 kb, 25 kb, 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived. Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material or culture medium when produced by recombinant techniques, or of chemical precursors or other chemicals when chemically synthesized.

[0053] A nucleic acid molecule of the present invention, e.g., a nucleic acid molecule having the nucleotide sequence of SEQ ID NO:2n−1 (wherein n=1 to 4534), or a complement of any of this nucleotide sequence, can be isolated using standard molecular biology techniques and the sequence information provided herein. Using all or a portion of the nucleic acid sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534) as a hybridization probe, ORFX nucleic acid sequences can be isolated using standard hybridization and cloning techniques (e.g., as described in Sambrook et al., eds., Molecular Cloning: A Laboratory Manual 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989; and Ausubel, et al., eds., Current Protocols in Molecular Biology, John Wiley & Sons, New York, N.Y., 1993.)

[0054] A nucleic acid of the invention can be amplified using cDNA, mRNA or alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to ORFX nucleotide sequences can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.

[0055] As used herein, the term “oligonucleotide” refers to a series of linked nucleotide residues, which oligonucleotide has a sufficient number of nucleotide bases to be used in a PCR reaction. A short oligonucleotide sequence may be based on, or designed from, a genomic or cDNA sequence and is used to amplify, confirm, or reveal the presence of an identical, similar or complementary DNA or RNA in a particular cell or tissue. Oligonucleotides comprise portions of a nucleic acid sequence having about 10 nt, 50 nt, or 100 nt in length, preferably about 15 nt to 30 nt in length. In one embodiment, an oligonucleotide comprising a nucleic acid molecule less than 100 nt in length would further comprise at lease 6 contiguous nucleotides of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), or a complement thereof. Oligonucleotides may be chemically synthesized and may be used as probes.

[0056] In another embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule that is a complement of the nucleotide sequence shown in any of SEQ ID NO:2n−1 (wherein n=1 to 4534). In another embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule that is a complement of the nucleotide sequence shown in any of SEQ ID NO:2n−1 (wherein n=1 to 4534), or a portion of this nucleotide sequence. A nucleic acid molecule that is complementary to the nucleotide sequence shown in is one that is sufficiently complementary to the nucleotide sequence shown in of any of SEQ ID NO:2n−1 (wherein n=1 to 4534) that it can hydrogen bond with little or no mismatches to the nucleotide sequence shown in of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), thereby forming a stable duplex.

[0057] As used herein, the term “complementary” refers to Watson-Crick or Hoogsteen base pairing between nucleotides units of a nucleic acid molecule, and the term “binding” means the physical or chemical interaction between two polypeptides or compounds or associated polypeptides or compounds or combinations thereof. Binding includes ionic, non-ionic, Von der Waals, hydrophobic interactions, etc. A physical interaction can be either direct or indirect. Indirect interactions may be through or due to the effects of another polypeptide or compound. Direct binding refers to interactions that do not take place through, or due to, the effect of another polypeptide or compound, but instead are without other substantial chemical intermediates.

[0058] Moreover, the nucleic acid molecule of the invention can comprise only a portion of the nucleic acid sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), e.g. a fragment that can be used as a probe or primer, or a fragment encoding a biologically active portion of ORFX. Fragments provided herein are defined as sequences of at least 6 (contiguous) nucleic acids or at least 4 (contiguous) amino acids, a length sufficient to allow for specific hybridization in the case of nucleic acids or for specific recognition of an epitope in the case of amino acids, respectively, and are at most some portion less than a full length sequence. Fragments may be derived from any contiguous portion of a nucleic acid or amino acid sequence of choice. Derivatives are nucleic acid sequences or amino acid sequences formed from the native compounds either directly or by modification or partial substitution. Analogs are nucleic acid sequences or amino acid sequences that have a structure similar to, but not identical to, the native compound but differs from it in respect to certain components or side chains. Analogs may be synthetic or from a different evolutionary origin and may have a similar or opposite metabolic activity compared to wild type.

[0059] Derivatives and analogs may be full length or other than full length, if the derivative or analog contains a modified nucleic acid or amino acid, as described below. Derivatives or analogs of the nucleic acids or proteins of the invention include, but are not limited to, molecules comprising regions that are substantially homologous to the nucleic acids or proteins of the invention, in various embodiments, by at least about 70%, 80%, 85%, 90%, 95%, 98%, or even 99% identity (with a preferred identity of 80-99%) over a nucleic acid or amino acid sequence of identical size or when compared to an aligned sequence in which the alignment is done by a computer homology program known in the art, or whose encoding nucleic acid is capable of hybridizing to the complement of a sequence encoding the aforementioned proteins under stringent, moderately stringent, or low stringent conditions. See e.g. Ausubel, et al., Current Protocols in Molecular Biology, John Wiley & Sons, New York, N.Y., 1993, and below. An exemplary program is the Gap program (Wisconsin Sequence Analysis Package, Version 8 for UNIX, Genetics Computer Group, University Research Park, Madison, Wis.) using the default settings, which uses the algorithm of Smith and Waterman (Adv. Appl. Math., 1981, 2: 482-489, which is incorporated herein by reference in its entirety).

[0060] A “homologous nucleic acid sequence” or “homologous amino acid sequence,” or variations thereof, refer to sequences characterized by a homology at the nucleotide level or amino acid level as discussed above. Homologous nucleotide sequences encode those sequences coding for isoforms of ORFX polypeptide. Isoforms can be expressed in different tissues of the same organism as a result of, for example, alternative splicing of RNA. Alternatively, isoforms can be encoded by different genes. In the present invention, homologous nucleotide sequences include nucleotide sequences encoding for a ORFX polypeptide of species other than humans, including, but not limited to, mammals, and thus can include, e.g., mouse, rat, rabbit, dog, cat cow, horse, and other organisms. Homologous nucleotide sequences also include, but are not limited to, naturally occurring allelic variations and mutations of the nucleotide sequences set forth herein. A homologous nucleotide sequence does not, however, include the nucleotide sequence encoding human ORFX protein. Homologous nucleic acid sequences include those nucleic acid sequences that encode conservative amino acid substitutions (see below) in any of SEQ ID NO:2n (wherein n=1 to 4534) as well as a polypeptide having ORFX activity. Biological activities of the ORFX proteins are described below. A homologous amino acid sequence does not encode the amino acid sequence of a human ORFX polypeptide.

[0061] The nucleotide sequence determined from the cloning of the human ORFX gene allows for the generation of probes and primers designed for use in identifying the cell types disclosed and/or cloning ORFX homologues in other cell types, e.g., from other tissues, as well as ORFX homologues from other mammals. The probe/primer typically comprises a substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, 25, 50, 100, 150, 200, 250, 300, 350 or 400 or more consecutive sense strand nucleotide sequence of SEQ ID NO:2n−1 (wherein n=1 to 4534); or an anti-sense strand nucleotide sequence of SEQ ID NO:2n−1 (wherein n=1 to 4534); or of a naturally occurring mutant of SEQ ID NO:2n−1 (wherein n=1 to 4534).

[0062] Probes based on the human ORFX nucleotide sequence can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In various embodiments, the probe further comprises a label group attached thereto, e.g., the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells or tissue which misexpress a ORFX protein, such as by measuring a level of a ORFX-encoding nucleic acid in a sample of cells from a subject e.g., detecting ORFX mRNA levels or determining whether a genomic ORFX gene has been mutated or deleted.

[0063] “A polypeptide having a biologically active portion of ORFX” refers to polypeptides exhibiting activity similar, but not necessarily identical to, an activity of a polypeptide of the present invention, including mature forms, as measured in a particular biological assay, with or without dose dependency. A nucleic acid fragment encoding a “biologically active portion of ORFX” can be prepared by isolating a portion of SEQ ID NO:2n−1 (wherein n=1 to 4534), that encodes a polypeptide having a ORFX biological activity (biological activities of the ORFX proteins are summarized in Table 1), expressing the encoded portion of ORFX protein (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of ORFX. For example, a nucleic acid fragment encoding a biologically active portion of ORFX can optionally include a domain as shown in Table 1, column 4.

[0064] ORFX Variants

[0065] The invention further encompasses nucleic acid molecules that differ from the disclosed ORFX nucleotide sequences due to degeneracy of the genetic code. These nucleic acids thus encode the same ORFX protein as that encoded by the nucleotide sequence shown in SEQ ID NO:2n−1 (wherein n=1 to 4534). In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in any of SEQ ID NO:2n (wherein n=1 to 4534).

[0066] In addition to the human ORFX nucleotide sequence shown in any of SEQ ID NO:2n−1 (wherein n=1 to 4534), it will be appreciated by those skilled in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of ORFX may exist within a population (e.g., the human population). Such genetic polymorphism in the ORFX gene may exist among individuals within a population due to natural allelic variation. As used herein, the terms “gene” and “recombinant gene” refer to nucleic acid molecules comprising an open reading frame encoding a ORFX protein, preferably a mammalian ORFX protein. Such natural allelic variations can typically result in 1-5% variance in the nucleotide sequence of the ORFX gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in ORFX that are the result of natural allelic variation and that do not alter the functional activity of ORFX are intended to be within the scope of the invention.

[0067] Moreover, nucleic acid molecules encoding ORFX proteins from other species, and thus that have a nucleotide sequence that differs from the human sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), are intended to be within the scope of the invention. Nucleic acid molecules corresponding to natural allelic variants and homologues of the ORFX cDNAs of the invention can be isolated based on their homology to the human ORFX nucleic acids disclosed herein using the human cDNAs, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions.

[0068] In another embodiment, an isolated nucleic acid molecule of the invention is at least 6 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534). In another embodiment, the nucleic acid is at least 10, 25, 50, 100, 250, 500 or 750 nucleotides in length. In another embodiment, an isolated nucleic acid molecule of the invention hybridizes to the coding region. As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other.

[0069] Homologs (i.e., nucleic acids encoding ORFX proteins derived from species other than human) or other related sequences (e.g., paralogs) can be obtained by low, moderate or high stringency hybridization with all or a portion of the particular human sequence as a probe using methods well known in the art for nucleic acid hybridization and cloning.

[0070] As used herein, the phrase “stringent hybridization conditions” refers to conditions under which a probe, primer or oligonucleotide will hybridize to its target sequence, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures than shorter sequences. Generally, stringent conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength, pH and nucleic acid concentration) at which 50% of the probes complementary to the target sequence hybridize to the target sequence at equilibrium. Since the target sequences are generally present at excess, at Tm, 50% of the probes are occupied at equilibrium. Typically, stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes, primers or oligonucleotides (e.g., 10 nt to 50 nt) and at least about 60° C. for longer probes, primers and oligonucleotides. Stringent conditions may also be achieved with the addition of destabilizing agents, such as formamide.

[0071] Stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. Preferably, the conditions are such that sequences at least about 65%, 70%, 75%, 85%, 90%, 95%, 98%, or 99% homologous to each other typically remain hybridized to each other. A non-limiting example of stringent hybridization conditions is hybridization in a high salt buffer comprising 6×SSC, 50 mM Tris-HCl (pH 7.5), 1 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.02% BSA, and 500 mg/ml denatured salmon sperm DNA at 65° C. This hybridization is followed by one or more washes in 0.2×SSC, 0.01% BSA at 50° C. An isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to the sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534) corresponds to a naturally occurring nucleic acid molecule. As used herein, a “naturally-occurring” nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein).

[0072] In a second embodiment, a nucleic acid sequence that is hybridizable to the nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), or fragments, analogs or derivatives thereof, under conditions of moderate stringency is provided. A non-limiting example of moderate stringency hybridization conditions are hybridization in 6×SSC, 5×Denhardt's solution, 0.5% SDS and 100 mg/ml denatured salmon sperm DNA at 55° C., followed by one or more washes in 1×SSC, 0.1% SDS at 37° C. Other conditions of moderate stringency that may be used are well known in the art. See, e.g., Ausubel et al. (eds.), 1993, Current Protocols in Molecular Biology, John Wiley & Sons, NY, and Kriegler, 1990, Gene Transfer and Expression, A Laboratory Manual, Stockton Press, NY.

[0073] In a third embodiment, a nucleic acid that is hybridizable to the nucleic acid molecule comprising the nucleotide sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), or fragments, analogs or derivatives thereof, under conditions of low stringency, is provided. A non-limiting example of low stringency hybridization conditions are hybridization in 35% formamide, 5×SSC, 50 mM Tris-HCl (pH 7.5), 5 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.2% BSA, 100 mg/ml denatured salmon sperm DNA, 10% (wt/vol) dextran sulfate at 40° C., followed by one or more washes in 2×SSC, 25 mM Tris-HCl (pH 7.4), 5 mM EDTA, and 0.1% SDS at 50° C. Other conditions of low stringency that may be used are well known in the art (e.g., as employed for cross-species hybridizations). See, e.g., Ausubel et al. (eds.), 1993, Current Protocols in Molecular Biology, John Wiley & Sons, NY, and Kriegler, 1990, Gene Transfer and Expression, A Laboratory Manual, Stockton Press, NY; Shilo and Weinberg, 1981, Proc Natl Acad Sci USA 78: 6789-6792.

[0074] Conservative Mutations

[0075] In addition to naturally-occurring allelic variants of the ORFX sequence that may exist in the population, the skilled artisan will further appreciate that changes can be introduced by mutation into the nucleotide sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534), thereby leading to changes in the amino acid sequence of the encoded ORFX protein, without altering the functional ability of the ORFX protein. For example, nucleotide substitutions leading to amino acid substitutions at “non-essential” amino acid residues can be made in the sequence of any of SEQ ID NO:2n−1 (wherein n=1 to 4534). A “non-essential” amino acid residue is a residue that can be altered from the wild-type sequence of ORFX without altering the biological activity, whereas an “essential” amino acid residue is required for biological activity. For example, amino acid residues that are conserved among the ORFX proteins of the present invention, are predicted to be particularly unamenable to alteration.

[0076] Amino acid residues that are conserved among members of an ORFX family members are predicted to be less amenable to alteration. For example, an ORFX protein according to the present invention can contain at least one domain (e.g., as shown in Table 1) that is a typically conserved region in an ORFX family member. As such, these conserved domains are not likely to be amenable to mutation. Other amino acid residues, however, (e.g., those that are not conserved or only semi-conserved among members of the ORFX family) may not be as essential for activity and thus are more likely to be amenable to alteration.

[0077] Another aspect of the invention pertains to nucleic acid molecules encoding ORFX proteins that contain changes in amino acid residues that are not essential for activity. Such ORFX proteins differ in amino acid sequence from any of any of SEQ ID NO:2n (wherein n=1 to 4534), yet retain biological activity. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 75% homologous to the amino acid sequence of any of SEQ ID NO:2n (wherein n=1 to 4534). Preferably, the protein encoded by the nucleic acid is at least about 80% homologous to any of SEQ ID NO:2n (wherein n=1 to 4534), more preferably at least about 90%, 95%, 98%, and most preferably at least about 99% homologous to SEQ ID NO:2.

[0078] An isolated nucleic acid molecule encoding a ORFX protein homologous to the protein of any of SEQ ID NO:2n (wherein n=1 to 4534) can be created by introducing one or more nucleotide substitutions, additions or deletions into the corresponding nucleotide sequence, i.e. SEQ ID NO:2n−1 for the corresponding n, such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein.

[0079] Mutations can be introduced into SEQ ID NO:2n−1 (wherein n=1 to 4534) by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A “conservative amino acid substitution” is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in ORFX is replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of a ORFX coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for ORFX biological activity to identify mutants that retain activity. Following mutagenesis of SEQ ID NO:2n−1 (wherein n=1 to 4534). the encoded protein can be expressed by any recombinant technology known in the art and the activity of the protein can be determined.

[0080] In one embodiment, a mutant ORFX protein can be assayed for (1) the ability to form protein:protein interactions with other ORFX proteins, other cell-surface proteins, or biologically active portions thereof, (2) complex formation between a mutant ORFX protein and a ORFX receptor; (3) the ability of a mutant ORFX protein to bind to an intracellular target protein or biologically active portion thereof; (e.g., avidin proteins); (4) the ability to bind BRA protein; or (5) the ability to specifically bind an anti-ORFX protein antibody.

[0081] Antisense

[0082] Another aspect of the invention pertains to isolated antisense nucleic acid molecules that are hybridizable to or complementary to the nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:2n−1 (wherein n=1 to 4534), or fragments, analogs or derivatives thereof. An “antisense” nucleic acid comprises a nucleotide sequence that is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, 25, 50, 100, 250 or 500 nucleotides or an entire ORFX coding strand, or to only a portion thereof. Nucleic acid molecules encoding fragments, homologs, derivatives and analogs of a ORFX protein of any of SEQ ID NO:2n (wherein n=1 to 4534) or antisense nucleic acids complementary to a ORFX nucleic acid sequence of SEQ ID NO:2n−1 (wherein n=1 to 4534) are additionally provided.

[0083] In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence encoding ORFX. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues (e.g., the protein coding region of a human ORFX that corresponds to any of SEQ ID NO:2n (wherein n=1 to 4534)). In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence encoding ORFX. The term “noncoding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions).

[0084] Given the coding strand sequences encoding ORFX disclosed herein (e.g., SEQ ID NO:2n−1 (wherein n=1 to 4534)), antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of ORFX mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of ORFX mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of ORFX mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used.

[0085] Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

[0086] The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a ORFX protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, e.g. by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens. The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred.

[0087] In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al. (1987) Nucleic Acids Res 15: 6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylibonucleotide (Inoue et al. (1987) Nucleic Acids Res 15: 6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987) FEBS Lett 215: 327-330).

[0088] Ribozymes and PNA Moieties

[0089] Such modifications include, by way of nonlimiting example, modified bases, and nucleic acids whose sugar phosphate backbones are modified or derivatized. These modifications are carried out at least in part to enhance the chemical stability of the modified nucleic acid, such that they may be used, for example, as antisense binding nucleic acids in therapeutic applications in a subject.

[0090] In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334:585-591)) can be used to catalytically cleave ORFX mRNA transcripts to thereby inhibit translation of ORFX mRNA. A ribozyme having specificity for a ORFX-encoding nucleic acid can be designed based upon the nucleotide sequence of a ORFX DNA disclosed herein (i.e., SEQ ID NO:2n−1 (wherein n=1 to 4534)). For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a ORFX-encoding mRNA. See, e.g., Cech et al. U.S. Pat. No. 4,987,071; and Cech et al. U.S. Pat. No. 5,116,742. Alternatively, ORFX mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel et al., (1993) Science 261:1411-1418.

[0091] Alternatively, ORFX gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of the ORFX (e.g., the ORFX promoter and/or enhancers) to form triple helical structures that prevent transcription of the ORFX gene in target cells. See generally, Helene. (1991) Anticancer Drug Des. 6: 569-84; Helene. et.al. (1992) Ann. N.Y. Acad. Sci. 660:27-36; and Maher (1992) Bioassays 14: 807-15.

[0092] In various embodiments, the nucleic acids of ORFX can be modified at the base moiety, sugar moiety or phosphate backbone to improve, e.g., the stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of the nucleic acids can be modified to generate peptide nucleic acids (see Hyrup et al. (1996) Bioorg Med Chem 4: 5-23). As used herein, the terms “peptide nucleic acids” or “PNAs” refer to nucleic acid mimics, e.g., DNA mimics, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of PNAs has been shown to allow for specific hybridization to DNA and RNA under conditions of low ionic strength. The synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described in Hyrup et al. (1996) above; Perry-O'Keefe et al. (1996) PNAS 93: 14670-675.

[0093] PNAs of ORFX can be used in therapeutic and diagnostic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, e.g., inducing transcription or translation arrest or inhibiting replication. PNAs of ORFX can also be used, e.g., in the analysis of single base pair mutations in a gene by, e.g., PNA directed PCR clamping; as artificial restriction enzymes when used in combination with other enzymes, e.g., S1 nucleases (Hyrup B. (1996) above); or as probes or primers for DNA sequence and hybridization (Hyrup et al. (1996), above; Perry-O'Keefe (1996), above).

[0094] In another embodiment, PNAs of ORFX can be modified, e.g., to enhance their stability or cellular uptake, by attaching lipophilic or other helper groups to PNA, by the formation of PNA-DNA chimeras, or by the use of liposomes or other techniques of drug delivery known in

[0095] In general, an ORFX-like variant that preserves ORFX-like function includes any variant in which residues at a particular position in the sequence have been substituted by other amino acids, and further include the possibility of inserting an additional residue or residues between two residues of the parent protein as well as the possibility of deleting one or more residues from the parent sequence. Any amino acid substitution, insertion, or deletion is encompassed by the invention. In favorable circumstances, the substitution is a conservative substitution as defined above. Furthermore, without limiting the scope of the invention, positions of any of SEQ ID NO:2n (wherein n=1 to 4534) may be substitute such that a mutant or variant protein may include one or more substitutions

[0096] The invention also includes isolated ORFX proteins, and biologically active portions thereof, or derivatives, fragments, analogs or homologs thereof Also provided are polypeptide fragments suitable for use as immunogens to raise anti-ORFX antibodies. In one embodiment, native ORFX proteins can be isolated from cells or tissue sources by an appropriate purification scheme using standard protein purification techniques. In another embodiment, ORFX proteins are produced by recombinant DNA techniques. Alternative to recombinant expression, a ORFX protein or polypeptide can be synthesized chemically using standard peptide synthesis techniques.

[0097] An “isolated” or “purified” protein or biologically active portion thereof is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the ORFX protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. The language “substantially free of cellular material” includes preparations of ORFX protein in which the protein is separated from cellular components of the cells from which it is isolated or recombinantly produced. In one embodiment, the language “substantially free of cellular material” includes preparations of ORFX protein having less than about 30% (by dry weight) of non-ORFX protein (also referred to herein as a “contaminating protein”), more preferably less than about 20% of non-ORFX protein, still more preferably less than about 10% of non-ORFX protein, and most preferably less than about 5% non-ORFX protein. When the ORFX protein or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation.

[0098] The language “substantially free of chemical precursors or other chemicals” includes preparations of ORFX protein in which the protein is separated from chemical precursors or other chemicals that are involved in the synthesis of the protein. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of ORFX protein having less than about 30% (by dry weight) of chemical precursors or non-ORFX chemicals, more preferably less than about 20% chemical precursors or non-ORFX chemicals, still more preferably less than about 10% chemical precursors or non-ORFX chemicals, and most preferably less than about 5% chemical precursors or non-ORFX chemicals.

[0099] Biologically active portions of a ORFX protein include peptides comprising amino acid sequences sufficiently homologous to or derived from the amino acid sequence of the ORFX protein, e.g., the amino acid sequence shown in SEQ ID NO:2 that include fewer amino acids than the full length ORFX proteins, and exhibit at least one activity of a ORFX protein. Typically, biologically active portions comprise a domain or motif with at least one activity of the ORFX protein. A biologically active portion of a ORFX protein can be a polypeptide which is, for example, 10, 25, 50, 100 or more amino acids in length.

[0100] A biologically active portion of a ORFX protein of the present invention may contain at least one of the above-identified domains conserved between the FGF family of proteins. Moreover, other biologically active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the functional activities of a native ORFX protein.

[0101] In an embodiment, the ORFX protein has an amino acid sequence shown in any of SEQ ID NO:2n (wherein n=1 to 4534). In other embodiments, the ORFX protein is substantially homologous to any of SEQ ID NO:2n (wherein n=1 to 4534) and retains the functional activity of the protein of any of SEQ ID NO:2n (wherein n=1 to 4534), yet differs in amino acid sequence due to natural allelic variation or mutagenesis, as described in detail below. Accordingly, in another embodiment, the ORFX protein is a protein that comprises an amino acid sequence at least about 45% homologous, and more preferably about 55, 65, 70, 75, 80, 85, 90, 95, 98 or even 99% homologous to the amino acid sequence of any of SEQ ID NO:2n (wherein n=1 to 4534) and retains the functional activity of the ORFX proteins of the corresponding polypeptide having the sequence of SEQ ID NO:2n (wherein n=1 to 4534).

[0102] Determining Homology Between Two or More Sequences

[0103] To determine the percent homology of two amino acid sequences or of two nucleic acids, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in either of the sequences being compared for optimal alignment between the sequences). The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are homologous at that position (i.e., as used herein amino acid or nucleic acid “homology” is equivalent to amino acid or nucleic acid “identity”).

[0104] The nucleic acid sequence homology may be determined as the degree of identity between two sequences. The homology may be determined using computer programs known in the art, such as GAP software provided in the GCG program package. See, Needleman and Wunsch 1970 J Mol Biol 48: 443-453. Using GCG GAP software with the following settings for nucleic acid sequence comparison: GAP creation penalty of 5.0 and GAP extension penalty of 0.3, the coding region of the analogous nucleic acid sequences referred to above exhibits a degree of identity preferably of at least 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99%, with the CDS (encoding) part of the DNA sequence shown in SEQ ID NO:2n−1 (wherein n=1 to 4534).

[0105] The term “sequence identity” refers to the degree to which two polynucleotide or polypeptide sequences are identical on a residue-by-residue basis over a particular region of comparison. The term “percentage of sequence identity” is calculated by comparing two optimally aligned sequences over that region of comparison,determining the number of positions at which the identical nucleic acid base (e.g., A, T, C, G, U, or I, in the case of nucleic acids) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the region of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of sequence identity. The term “substantial identity” as used herein denotes a characteristic of a polynucleotide sequence, wherein the polynucleotide comprises a sequence that has at least 80 percent sequence identity, preferably at least 85 percent identity and often 90 to 95 percent sequence identity, more usually at least 99 percent sequence identity as compared to a reference sequence over a comparison region. The term “percentage of positive residues” is calculated by comparing two optimally aligned sequences over that region of comparison, determining the number of positions at which the identical and conservative amino acid substitutions, as defined above, occur in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the region of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of positive residues.

[0106] Chimeric and Fusion Proteins

[0107] The invention also provides ORFX chimeric or fusion proteins. As used herein, a ORFX “chimeric protein” or “fusion protein” includes a ORFX polypeptide operatively linked to a non-ORFX polypeptide. A “ORFX polypeptide” refers to a polypeptide having an amino acid sequence corresponding to ORFX, whereas a “non-ORFX polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a protein that is not substantially homologous to the ORFX protein, e.g., a protein that is different from the ORFX protein and that is derived from the same or a different organism. Within a ORFX fusion protein the ORFX polypeptide can correspond to all or a portion of a ORFX protein. In one embodiment, a ORFX fusion protein comprises at least one biologically active portion of a ORFX protein. In another embodiment, a ORFX fusion protein comprises at least two biologically active portions of a ORFX protein. Within the fusion protein, the term “operatively linked” is intended to indicate that the ORFX polypeptide and the non-ORFX polypeptide are fused in-frame to each other. The non-ORFX polypeptide can be fused to the N-terminus or C-terminus of the ORFX polypeptide.

[0108] For example, in one embodiment a ORFX fusion protein comprises a ORFX polypeptide operably linked to the extracellular domain of a second protein. Such fusion proteins can be further utilized in screening assays for compounds that modulate ORFX activity (such assays are described in detail below).

[0109] In another embodiment, the fusion protein is a GST-ORFX fusion protein in which the ORFX sequences are fused to the C-terminus of the GST (i.e., glutathione S-transferase) sequences. Such fusion proteins can facilitate the purification of recombinant ORFX.

[0110] In yet another embodiment, the fusion protein is a ORFX protein containing a heterologous signal sequence at its N-terminus. For example, the native ORFX signal sequence can be removed and replaced with a signal sequence from another protein. In certain host cells (e.g., mammalian host cells), expression and/or secretion of ORFX can be increased through use of a heterologous signal sequence.

[0111] In another embodiment, the fusion protein is a ORFX-immunoglobulin fusion protein in which the ORFX sequences comprising one or more domains are fused to sequences derived from a member of the immunoglobulin protein family. The ORFX-immunoglobulin fusion proteins of the invention can be incorporated into pharmaceutical compositions and administered to a subject to inhibit an interaction between a ORFX ligand and a ORFX protein on the surface of a cell, to thereby suppress ORFX-mediated signal transduction in vivo. In one nonlimiting example, a contemplated ORFX ligand of the invention is an ORFX receptor. The ORFX-immunoglobulin fusion proteins can be used to modulate the bioavailability of a ORFX cognate ligand. Inhibition of the ORFX ligand/ORFX interaction may be useful therapeutically for both the treatment of proliferative and differentiative disorders, as well as modulating (e.g., promoting or inhibiting) cell survival. Moreover, the ORFX-immunoglobulin fusion proteins of the invention can be used as immunogens to produce anti-ORFX antibodies in a subject, to purify ORFX ligands, and in screening assays to identify molecules that inhibit the interaction of ORFX with a ORFX ligand.

[0112] A ORFX chimeric or fusion protein of the invention can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, e.g., by employing blunt-ended or stagger-ended termnini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers that give rise to complementary overhangs between two consecutive gene fragments that can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example, Ausubel et al. (eds.) Current Protocols in Molecular Biology, John Wiley & Sons, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). A ORFX-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the ORFX protein.

[0113] ORFX Agonists and Antagonists

[0114] The present invention also pertains to variants of the ORFX proteins that function as either ORFX agonists (mimetics) or as ORFX antagonists. Variants of the ORFX protein can be generated by mutagenesis, e.g., discrete point mutation or truncation of the ORFX protein. An agonist of the ORFX protein can retain substantially the same, or a subset of, the biological activities of the naturally occurring form of the ORFX protein. An antagonist of the ORFX protein can inhibit one or more of the activities of the naturally occurring form of the ORFX protein by, for example, competitively binding to a downstream or upstream member of a cellular signaling cascade which includes the ORFX protein. Thus, specific biological effects can be elicited by treatment with a variant of limited function. In one embodiment, treatment of a subject with a variant having a subset of the biological activities of the naturally occurring form of the protein has fewer side effects in a subject relative to treatment with the naturally occurring form of the ORFX proteins.

[0115] Variants of the ORFX protein that function as either ORFX agonists (mimetics) or as ORFX antagonists can be identified by screening combinatorial libraries of mutants, e.g., truncation mutants, of the ORFX protein for ORFX protein agonist or antagonist activity. In one embodiment, a variegated library of ORFX variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of ORFX variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential ORFX sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins (e.g., for phage display) containing the set of ORFX sequences therein. There are a variety of methods which can be used to produce libraries of potential ORFX variants from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential ORFX sequences. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang (1983) Tetrahedron 39:3; Itakura et al. (1984) Annu Rev Biochem 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucl Acid Res 11:477.

[0116] Polypeptide Libraries

[0117] In addition, libraries of fragments of the ORFX protein coding sequence can be used to generate a variegated population of ORFX fragments for screening and subsequent selection of variants of a ORFX protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of a ORFX coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA that can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S1 nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal and internal fragments of various sizes of the ORFX protein.

[0118] Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of ORFX proteins. The most widely used techniques, which are amenable to high throughput analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recrusive ensemble mutagenesis (REM), a new technique that enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify ORFX variants (Arkin and Yourvan (1992) PNAS 89:7811-7815; Delgrave et al. (1993) Protein Engineering 6:327-331).

[0119] Anti-ORFX Antibodies

[0120] The invention further encompasses antibodies and antibody fragments, such as Fab or (Fab)2, that bind immunospecifically to any of the proteins of the invention.

[0121] An isolated ORFX protein, or a portion or fragment thereof, can be used as an immunogen to generate antibodies that bind ORFX using standard techniques for polyclonal and monoclonal antibody preparation. Full-length ORFX protein can be used. Alternatively, the invention provides antigenic peptide fragments of ORFX for use as immunogens. The antigenic peptide of ORFX comprises at least 4 amino acid residues of the amino acid sequence shown in any of SEQ ID NO:2n (wherein n=1 to 4534). The antigenic peptide encompasses an epitope of ORFX such that an antibody raised against the peptide forms a specific immune complex with ORFX. The antigenic peptide may comprise at least 6 aa residues, at least 8 aa residues, at least 10 aa residues, at least 15 aa residues, at least 20 aa residues, or at least 30 aa residues. In one embodiment of the invention, the antigenic peptide comprises a polypeptide comprising at least 6 contiguous amino acids of any of SEQ ID NO:2n (wherein n=1 to 4534).

[0122] In an embodiment of the invention, epitopes encompassed by the antigenic peptide are regions of ORFX that are located on the surface of the protein, e.g., hydrophilic regions. As a means for targeting antibody production, hydropathy plots showing regions of hydrophilicity and hydrophobicity may be generated by any method well known in the art, including, for example, the Kyte Doolittle or the Hopp Woods methods, either with or without Fourier transformation. See, e.g., Hopp and Woods, 1981, Proc. Nat. Acad. Sci. USA 78: 3824-3828; Kyte and Doolittle 1982, J. Mol. Biol. 157: 105-142, each incorporated herein by reference in their entirety.

[0123] As disclosed herein, an ORFX protein sequence of any of SEQ ID NO:2n (wherein n=1 to 4534), or derivatives, fragments, analogs or homologs thereof, may be utilized as immunogens in the generation of antibodies that immunospecifically-bind these protein components. The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that specifically binds (immunoreacts with) an antigen, such as ORFX. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, Fab and F(ab′)2 fragments, and an Fab expression library. In a specific embodiment, antibodies to human ORFX proteins are disclosed. Various procedures known within the art may be used for the production of polyclonal or monoclonal antibodies to a ORFX protein sequence of any of SEQ ID NO:2n (wherein n=1 to 4534) or derivative, fragment, analog or homolog thereof. Some of these proteins are discussed below.

[0124] For the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by injection with the native protein, or a synthetic variant thereof, or a derivative of the foregoing. An appropriate immunogenic preparation can contain, for example, recombinantly expressed ORFX protein or a chemically synthesized ORFX polypeptide. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, but are not limited to, Freund's (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface active substances (e.g., lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, etc.), human adjuvants such as Bacille Calmette-Guerin and Corynebacterium parvum, or similar immunostimulatory agents. If desired, the antibody molecules directed against ORFX can be isolated from the mammal (e.g., from the blood) and further purified by well known techniques, such as protein A chromatography to obtain the IgG fraction.

[0125] The term “monoclonal antibody” or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one species of an antigen binding site capable of immunoreacting with a particular epitope of ORFX. A monoclonal antibody composition thus typically displays a single binding affinity for a particular ORFX protein with which it immunoreacts. For preparation of monoclonal antibodies directed towards a particular ORFX protein, or derivatives, fragments, analogs or homologs thereof, any technique that provides for the production of antibody molecules by continuous cell line culture may be utilized. Such techniques include, but are not limited to, the hybridoma technique (see Kohler & Milstein, 1975 Nature 256: 495-497); the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., 1983 Immunol Today 4: 72) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., 1985 In: Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al., 1983. Proc Natl Acad Sci USA 80: 2026-2030) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al., 1985 In: Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Each of the above citations are incorporated herein by reference in their entirety

[0126] According to the invention, techniques can be adapted for the production of single-chain antibodies specific to a ORFX protein (see e.g., U.S. Pat. No. 4,946,778). In addition, methods can be adapted for the construction of Fab expression libraries (see e.g., Huse, et al., 1989 Science 246: 1275-1281) to allow rapid and effective identification of monoclonal Fab fragments with the desired specificity for a ORFX protein or derivatives, fragments, analogs or homologs thereof. Non-human antibodies can be “humanized” by techniques well known in the art. See e.g., U.S. Pat. No. 5,225,539. Each of the above citations are incorporated herein by reference. Antibody fragments that contain the idiotypes to a ORFX protein may be produced by techniques known in the art including, but not limited to: (i) an F(ab′)2 fragment produced by pepsin digestion of an antibody molecule; (ii) an Fab fragment generated by reducing the detect ORFX protein (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the ORFX protein. Anti-ORFX antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidintbiotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerytlirin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include 125I, 131I, 35S or 3H.

[0127] ORFX Recombinant Vectors and Host Cells

[0128] Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding ORFX protein, or derivatives, fragments, analogs or homologs thereof. As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid”, which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as “expression vectors”. In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, “plasmid” and “vector” can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions.

[0129] The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, that is operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner that allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term “regulatory sequence” is intended to includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence in many types of host cell and those that direct expression of the nucleotide sequence only in certain host cells (e.g., tissue-specific regulatory sequences). It will be appreciated by those skilled in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein (e.g., ORFX proteins, mutant forms of ORFX, fusion proteins, etc.).

[0130] The recombinant expression vectors of the invention can be designed for expression of ORFX in prokaryotic or eukaryotic cells. For example, ORFX can be expressed in bacterial cells such as E. coli, insect cells (using baculovirus expression vectors) yeast cells or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

[0131] Expression of proteins in prokaryotes is most often carried out in E. coli with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein. Such fusion vectors typically serve three purposes: (1) to increase expression of recombinant protein; (2) to increase the solubility of the recombinant protein; and (3) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith and Johnson (1988) Gene 67:31-40), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) that fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein.

[0132] Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amrann et al., (1988) Gene 69:301-315) and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990) 60-89).

[0133] One strategy to maximize recombinant protein expression in E. coli is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein. See, Gottesman, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990) 119-128. Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in E. coli (Wada et al., (1992) Nucleic Acids Res. 20:2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.

[0134] In another embodiment, the ORFX expression vector is a yeast expression vector. Examples of vectors for expression in yeast S. cerivisae include pYepSec1 (Baldari, et al., (1987) EMBO J 6:229-234), pMFa (Kurjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), pYES2 (Invitrogen Corporation, San Diego, Calif.), and picZ (InVitrogen Corp, San Diego, Calif.).

[0135] Alternatively, ORFX can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., SF9 cells) include the pAc series (Smith et al. (1983) Mol Cell Biol 3:2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170:31-39).

[0136] In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed (1987) Nature 329:840) and pMT2PC (Kaufman et al. (1987) EMBO J 6: 187-195). When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells. See, e.g., Chapters 16 and 17 of Sambrook et al., Molecular Cloning: A Laboratory Manual. 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.

[0137] In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al. (1987) Genes Dev 1:268-277), lymphoid-specific promoters (Calame and Eaton (1988) Adv Immunol 43:235-275), in particular promoters of T cell receptors (Winoto and Baltimore (1989) EMBO J 8:729-733) and immunoglobulins (Banerji et al. (1983) Cell 33:729-740; Queen and Baltimore (1983) Cell 33:741-748), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle (1989) PNAS 86:5473-5477), pancreas-specific promoters (Edlund et al. (1985) Science 230:912-916), and mammary gland-specific promoters (e.g.,.milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are also encompassed, e.g., the murine hox promoters (Kessel and Gruss (1990) Science 249:374-379) and the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev 3:537-546).

[0138] The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in a manner that allows for expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to ORFX mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen that direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen that direct constitutive, tissue specific, or cell type specific expression of antisense RNA. The antisense expression vector can be in the. form of a recombinant plasmid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see Weintraub et al., “Antisense RNA as a molecular tool for genetic analysis,” Reviews—Trends in Genetics, Vol. 1(1) 1986.

[0139] Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms “host cell” and “recombinant host cell” are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.

[0140] A host cell can be any prokaryotic or eukaryotic cell. For example, ORFX protein can be expressed in bacterial cells such as E. coli, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art.

[0141] Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g. DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual. 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.

[0142] For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Various selectable markers include those that confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding ORFX or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).

[0143] A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) ORFX protein. Accordingly, the invention further provides methods for producing ORFX protein using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding ORFX has been introduced) in a suitable medium such that ORFX protein is produced. In another embodiment, the method further comprises isolating ORFX from the medium or the host cell.

[0144] Transgenic Animals

[0145] The host cells of the invention can also be used to produce nonhuman transgenic animals. For example, in one embodiment, a host cell of the invention is a fertilized oocyte or an embryonic stem cell into which ORFX-coding sequences have been introduced. Such host cells can then be used to create non-human transgenic animals in which exogenous ORFX sequences have been introduced into their genome or homologous recombinant animals in which endogenous ORFX sequences have been altered. Such animals are useful for studying the function and/or activity of ORFX and for identifying and/or evaluating modulators of ORFX activity. As used herein, a “transgenic animal” is a non-human animal, preferably a mammal, more preferably a rodent such as a rat or mouse, in which one or more of the cells of the animal includes a transgene. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens, amphibians, etc. A transgene is exogenous DNA that is integrated into the genome of a cell from which a transgenic animal develops and that remains in the genome of the mature animal, thereby directing the expression of an encoded gene product in one or more cell types or tissues of the transgenic animal. As used herein, a “homologous recombinant animal” is a non-human animal, preferably a mammal, more preferably a mouse, in which an endogenous ORFX gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal, e.g., an embryonic cell of the animal, prior to development of the animal.

[0146] A transgenic animal of the invention can be created by introducing ORFX-encoding nucleic acid into the male pronuclei of a fertilized oocyte, e.g., by microinjection, retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. The human ORFX DNA sequence of SEQ ID NO:2n−1 (wherein n=1 to 4534) can be introduced as a transgene into the genome of a non-human animal. Alternatively, a nonhuman homologue of the human ORFX gene, such as a mouse ORFX gene, can be isolated based on hybridization to the human ORFX cDNA (described further above) and used as a transgene. Intronic sequences and polyadenylation signals can also be included in the transgene to increase the efficiency of expression of the transgene. A tissue-specific regulatory sequence(s) can be operably linked to the ORFX transgene to direct expression of ORFX protein to particular cells. Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866; 4,870,009; and 4,873,191; and Hogan 1986, In: Manipulating the Mouse Embryo, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the ORFX transgene in its genome and/or expression of ORFX mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene encoding ORFX can further be bred to other transgenic animals carrying other transgenes.

[0147] To create a homologous recombinant animal, a vector is prepared which contains at least a portion of a ORFX gene into which a deletion, addition or substitution has been introduced to thereby alter, e.g., functionally disrupt, the ORFX gene. The ORFX gene can be a human gene (e.g., SEQ ID NO:2n−1 (wherein n=1 to 4534)), but more preferably, is a non-human homologue of a human ORFX gene. For example, a mouse homologue of human ORFX gene of SEQ ID NO:2n−1 (wherein n=1 to 4534) can be used to construct a homologous recombination vector suitable for altering an endogenous ORFX gene in the mouse genome. In one embodiment, the vector is designed such that, upon homologous recombination; the endogenous ORFX gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a “knock out” vector).

[0148] Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous ORFX gene is mutated or otherwise altered but still encodes functional protein (e.g., the upstream regulatory region can be altered to thereby alter the expression of the endogenous ORFX protein). In the homologous recombination vector, the altered portion of the ORFX gene is flanked at its 5′ and 3′ ends by additional nucleic acid of the ORFX gene to allow for homologous recombination to occur between the exogenous ORFX gene carried by the vector and an endogenous ORFX gene in an embryonic stem cell. The additional flanking ORFX nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both at the 5′ and 3′ ends) are included in the vector. See e.g., Thomas et al. (1987) Cell 51:503 for a description of homologous recombination vectors. The vector is introduced into an embryonic stem cell line (e.g., by electroporation) and cells in which the introduced ORFX gene has homologously recombined with the endogenous ORFX gene are selected (see e.g., Li et al. (1992) Cell 69:915).

[0149] The selected cells are then injected into a blastocyst of an animal (e.g., a mouse) to form aggregation chimeras. See e.g., Bradley 1987, In: Teratocarcinomas and Embryonic Stem Cells: A Practical Approach, Robertson, ed. IRL, Oxford, pp. 113-152. A chimeric embryo can then be implanted into a suitable pseudopregnant female foster animal and the embryo brought to term. Progeny harboring the homologously recombined DNA in their germ cells can be used to breed animals in which all cells of the animal contain the homologously recombined DNA by germline transmission of the transgene. Methods for constructing homologous recombination vectors and homologous recombinant animals are described further in Bradley (1991) Curr Opin Biotechnol 2:823-829; PCT International Publication Nos.: WO 90/11354; WO 91/01140; WO 92/0968; and WO 93/04169.

[0150] In another embodiment, transgenic non-humans animals can be produced that contain selected systems that allow for regulated expression of the transgene. One example of such a

[0151] A pharmaceutical composition of the invention is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates, and agents for the adjustment of tonicity such as sodium chloride or dextrose. The pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic.

[0152] Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringeability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as manitol, sorbitol, sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin.

[0153] Sterile injectable solutions can be prepared by incorporating the active compound (e g., a ORFX protein or anti-ORFX antibody) in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, methods of preparation are vacuum drying and freeze-drying that yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.

[0154] Oral compositions generally include an inert diluent or an edible carrier. They can be enclosed in gelatin capsules or compressed into tablets. For the purpose of oral therapeutic administration, the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash, wherein the compound in the fluid carrier is applied orally and swished and expectorated or swallowed. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring.

[0155] For administration by inhalation, the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propellant, e.g., a gas such as carbon dioxide, or a nebulizer.

[0156] Systemic administration can also be by transmucosal or transdermal means. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are, generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. For transdermal administration, the active compounds are formulated into ointments, salves, gels, or creams as generally known in the art.

[0157] The compounds can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery.

[0158] In one embodiment, the active compounds are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. The materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811.

[0159] It is especially advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specification for the dosage unit forms of the invention are dictated by and directly dependent on the unique characteristics of the active compound and the particular therapeutic effect to be achieved.

[0160] The nucleic acid molecules of the invention can be inserted into vectors and used as gene therapy vectors. Gene therapy vectors can be delivered to a subject by any of a number of routes, e.g., as described in U.S. Pat. No. 5,703,055. Delivery can thus also include, e.g., intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or stereotactic injection (see e.g., Chen et al. (1994) PNAS 91:3054-3057). The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells, e.g., retroviral vectors, the pharmaceutical preparation can include one or more cells that produce the gene delivery system.

[0161] The pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration.

[0162] Additional Uses and Methods of the Invention

[0163] The nucleic acid molecules, proteins, protein homologues, and antibodies described herein can be used in one or more of the following methods: (a) screening assays; (b) detection assays (e.g., chromosomal mapping, cell and tissue typing, forensic biology), (c) predictive medicine (e.g., diagnostic assays, prognostic assays, monitoring clinical trials, and pharmacogenomics); and (d) methods of treatment (e.g., therapeutic and prophylactic).

[0164] The isolated nucleic acid molecules of the invention can be used to express ORFX protein (e.g., via a recombinant expression vector in a host cell in gene therapy applications), to detect ORFX mRNA (e.g., in a biological sample) or a genetic lesion in a ORFX gene, and to modulate ORFX activity, as described further below. In addition, the ORFX proteins can be used to screen drugs or compounds that modulate the ORFX activity or expression as well as to treat disorders characterized by insufficient or excessive production of ORFX protein, for example proliferative or differentiative disorders, or production of ORFX protein forms that have decreased or aberrant activity compared to ORFX wild type protein. In addition, the anti-ORFX antibodies of the invention can be used to detect and isolate ORFX proteins and modulate ORFX activity.

[0165] This invention further pertains to novel agents identified by the above described screening assays and uses thereof for treatments as described herein.

[0166] Screening Assays

[0167] The invention provides a method (also referred to herein as a “screening assay”) for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, small molecules or other drugs) that bind to ORFX proteins or have a stimulatory or inhibitory effect on, for example, ORFX. expression or ORFX activity.

[0168] In one embodiment, the invention provides assays for screening candidate or test compounds which bind to or modulate the activity of a ORFX protein or polypeptide or biologically active portion thereof. The test compounds of the present invention can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the “one-bead one-compound” library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam (1997) Anticancer Drug Des 12:145).

[0169] Examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt et al. (1993) Proc Natl Acad Sci U.S.A. 90:6909; Erb et al. (1994) Proc Natl Acad Sci U.S.A. 91:11422; Zuckermann et al. (1994) J Med Chem 37:2678; Cho et al. (1993) Science 261:1303; Carrell et.al. (1994) Angew Chem Int Ed Engl 33:2059; Carell et.al. (1994) Angew Chem Int Ed Engl 33:2061; and Gallop et al. (1994) J Med Chem 37:1233.

[0170] Libraries of compounds may be presented in solution (e.g., Houghten (1992) Biotechniques 13:412-421), or on beads (Lam (1991) Nature 354:82-84), on chips (Fodor (1993) Nature 364:555-556), bacteria (Ladner U.S. Pat. No. 5,223,409), spores (Ladner U.S. Pat. No. '409), plasmids (Cull et al. (1992) Proc Natl Acad Sci USA 89:1865-1869) or on phage (Scott and Smith (1990) Science 249:386-390; Devlin (1990) Science 249:404-406; Cwirla et.al. (1990) Proc Natl Acad Sci U.S.A. 87:6378-6382; Felici (1991) J Mol Biol 222:301-310; Ladner above.).

[0171] In one embodiment, an assay is a cell-based assay in which a cell which expresses a membrane-bound form of ORFX protein, or a biologically active portion thereof, on the cell surface is contacted with a test compound and the ability of the test compound to bind to a ORFX protein determined. The cell, for example, can of mammalian origin or a yeast cell. Determining the ability of the test compound to bind to the ORFX protein can be accomplished, for example, by coupling the test compound with a radioisotope or enzymatic label such that binding of the test compound to the ORFX protein or biologically active portion thereof can be determined by detecting the labeled compound in a complex. For example, test compounds can be labeled with 125I, 35S, 14C, or 3H, either directly or indirectly, and the radioisotope detected by direct counting of radioemission or by scintillation counting. Alternatively, test compounds can be enzymatically labeled with, for example, horseradish peroxidase, alkaline phosphatase, or luciferase, and the enzymatic label detected by determination of conversion of an appropriate substrate to product. In one embodiment, the assay comprises contacting a cell which expresses a membrane-bound form of ORFX protein, or a biologically active portion thereof, on the cell surface with a known compound which binds ORFX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a ORFX protein, wherein determining the ability of the test compound to interact with a ORFX protein comprises determining the ability of the test compound to preferentially bind to ORFX or a biologically active portion thereof as compared to the known compound.

[0172] In another embodiment, an assay is a cell-based assay comprising contacting a cell expressing a membrane-bound form of ORFX protein, or a biologically active portion thereof, on the cell surface with a test compound and determining the ability of the test compound to modulate (e.g., stimulate or inhibit) the activity of the ORFX protein or biologically active portion thereof. Determining the ability of the test compound to modulate the activity of ORFX or a biologically active portion thereof can be accomplished, for example, by determining the ability of the ORFX protein to bind to or interact with a ORFX target molecule. As used herein, a “target molecule” is a molecule with which a ORFX protein binds or interacts in nature, for example, a molecule on the surface of a cell which expresses a ORFX interacting protein, a molecule on the surface of a second cell, a molecule in the extracellular milieu, a molecule associated with the internal surface of a cell membrane or a cytoplasmic molecule. A ORFX target molecule can be a non-ORFX molecule or a ORFX protein or polypeptide of the present invention. In one embodiment, a ORFX target molecule is a component of a signal transduction pathway that facilitates transduction of an extracellular signal (e.g., a signal generated by binding of a compound to a membrane-bound ORFX molecule) through the cell membrane and into the cell. The target, for example, can be a second intercellular protein that has catalytic activity or a protein that facilitates the association of downstream signaling molecules with ORFX.

[0173] Determining the ability of the ORFX protein to bind to or interact with a ORFX target molecule can be accomplished by one of the methods described above for determining direct binding. In one embodiment, determining the ability of the ORFX protein to bind to or interact with a ORFX target molecule can be accomplished by determining the activity of the target molecule. For example, the activity of the target molecule can be determined by detecting induction of a cellular second messenger of the target (i.e. intracellular Ca2+, diacylglycerol, IP3, etc.), detecting catalytic/enzymatic activity of the target an appropriate substrate, detecting the induction of a reporter gene (comprising a ORFX-responsive regulatory element operatively linked to a nucleic acid encoding a detectable marker, e.g., luciferase), or detecting a cellular response, for example, cell survival, cellular differentiation, or cell proliferation.

[0174] In yet another embodiment, an assay of the present invention is a cell-free assay comprising contacting a ORFX protein or biologically active portion thereof with a test compound and determining the ability of the test compound to bind to the ORFX protein or biologically active portion thereof. Binding of the test compound to the ORFX protein can be determined either directly or indirectly as described above. In one embodiment, the assay comprises contacting the ORFX protein or biologically active portion thereof with a known compound which binds ORFX to form an assay mixture, contacting the assay mixture with a test compound, and determining the, ability of the test compound to interact with a ORFX protein, wherein determining the ability of the test compound to interact with a ORFX protein comprises determining the ability of the test compound to preferentially bind to ORFX or biologically active portion thereof as compared to the known compound.

[0175] In another embodiment, an assay is a cell-free assay comprising contacting ORFX protein or biologically active portion thereof with a test compound and determining the ability of the test compound to modulate (e.g., stimulate or inhibit) the activity of the ORFX protein or biologically active portion thereof. Determining the ability of the test compound to modulate the activity of ORFX can be accomplished, for example, by determining the ability of the ORFX protein to bind to a ORFX target molecule by one of the methods described above for determining direct binding. In an alternative embodiment, determining the ability of the test compound to modulate the activity of ORFX can be accomplished by determining the ability of the ORFX protein further modulate a ORFX target molecule. For example, the catalytic/enzymatic activity of the target molecule on an appropriate substrate can be determined as previously described.

[0176] In yet another embodiment, the cell-free assay comprises contacting the ORFX protein or biologically active portion thereof with a known compound which binds ORFX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a ORFX protein, wherein determining the ability of the test compound to interact with a ORFX protein comprises determining the ability of the ORFX protein to preferentially bind to or modulate the activity of a ORFX target molecule.

[0177] The cell-free assays of the present invention are amenable to use of both the soluble form or the membrane-bound form of ORFX. In the case of cell-free assays comprising the membrane-bound form of ORFX, it may be desirable to utilize a solubilizing agent such that the membrane-bound form of ORFX is maintained in solution. Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N-methylglucamide, decanoyl-N-methylglucamide, Triton® X-100, Tritono® X-114, Thesit®, Isotridecypoly(ethylene glycol ether)n, N-dodecyl—N,N-dimethyl-3-ammonio-1-propane sulfonate, 3-(3-cholaridopropyl)dimethylamminiol-1-propane sulfonate (CHAPS), or 3-(3-cholamidopropyl)dimethylamminiol-2-hydroxy-1-propane sulfonate (CHAPSO).

[0178] In more than one embodiment of the above assay methods of the present invention, it may be desirable to immobilize either ORFX or its target molecule to facilitate separation of complexed from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. Binding of a test compound to ORFX, or interaction of ORFX with a target molecule in the presence and absence of a candidate compound, can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtiter plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion protein can be provided that adds a domain that allows one or both of the proteins to be bound to a matrix. For example, GST-ORFX fusion proteins or GST-target fusion proteins can be adsorbed onto glutathione sepharose beads (Sigmna Chemical, St. Louis, Mo.) or glutathione derivatized microtiter plates, that are then combined with the test compound or the test compound and either the non-adsorbed target protein or ORFX protein, and the mixture is incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads or microtiter plate wells are washed to remove any unbound components, the matrix immobilized in the case of beads, complex determined either directly or indirectly, for example, as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of ORFX binding or activity determined using standard techniques.

[0179] Other techniques for immobilizing proteins on matrices can also be used in the screening assays of the invention. For example, either ORFX or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin. Biotinylated ORFX or target molecules can be prepared from biotin-NHS (N-hydroxy-succinimide) using techniques well known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, Ill.), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical). Alternatively, antibodies reactive with ORFX or target molecules, but which do not interfere with binding of the ORFX protein to its target molecule, can be derivatized to the wells of the plate, and unbound target or ORFX trapped in the wells by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the ORFX or target molecule, as well as enzyme-linked assays that rely on detecting an enzymatic activity associated with the ORFX or target molecule.

[0180] In another embodiment, modulators of ORFX expression are identified in a method wherein a cell is contacted with a candidate compound and the expression of ORFX mRNA or protein in the cell is determined. The level of expression of ORFX mRNA or protein in the presence of the candidate compound is compared to the level of expression of ORFX mRNA or protein in the absence of the candidate compound. The candidate compound can then be identified as a modulator of ORFX expression based on this comparison. For example, when expression of ORFX mRNA or protein is greater (statistically significantly greater) in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of ORFX mRNA or protein expression. Alternatively, when expression of ORFX mRNA or protein is less (statistically significantly less) in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of ORFX mRNA or protein expression. The level of ORFX mRNA or protein expression in the cells can be determined by methods described herein for detecting ORFX mRNA or protein.

[0181] In yet another aspect of the invention, the ORFX proteins can be used as “bait proteins” in a two-hybrid assay or three hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al. (1993) Cell 72:223-232; Madura et al. (1993) J Biol Chem 268:12046-12054; Bartel et al. (1993) Biotechniques 14:920-924; Iwabuchi et al. (1993) Oncogene 8:1693-1696; and Brent WO94/10300), to identify other proteins that bind to or interact with ORFX (“ORFX-binding proteins” or “ORFX-bp”) and modulate ORFX activity. Such ORFX-binding proteins are also likely to be involved in the propagation of signals by the ORFX proteins as, for example, upstream or downstream elements of the ORFX pathway.

[0182] The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for ORFX is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. If the “bait” and the “prey” proteins are able to interact, in vivo, forming a ORFX-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) that is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene that encodes the protein which interacts with ORFX.

[0183] This invention further pertains to novel agents identified by the above-described screening assays and uses thereof for treatments as described herein.

[0184] Detection Assays

[0185] Portions or fragments of the cDNA sequences identified herein (and the corresponding complete gene sequences) can be used in numerous ways as polynucleotide reagents. For example, these sequences can be used to: (i) map their respective genes on a chromosome; and, thus, locate gene regions associated with genetic disease; (ii) identify an individual from a minute biological sample (tissue typing); and (iii) aid in forensic identification of a biological sample.

[0186] The ORFX sequences of the present invention can also be used to identify individuals from minute biological samples. In this technique, an individual's genomic DNA is digested with one or more restriction enzymes, and probed on a Southern blot to yield unique bands for identification. The sequences of the present invention are useful as additional DNA markers for RFLP (“restriction fragment length polymorphisms,” described in U.S. Pat. No. 5,272,057).

[0187] Furthermore, the sequences of the present invention can be used to provide an alternative technique that determines the actual base-by-base DNA sequence of selected portions of an individual's genome. Thus, the ORFX sequences described herein can be used to prepare two PCR primers from the 5′ and 3′ ends of the sequences. These primers can then be used to amplify an individual's DNA and subsequently sequence it.

[0188] Panels of corresponding DNA sequences from individuals, prepared in this manner, can provide unique individual identifications, as each individual will have a unique set of such DNA sequences due to allelic differences. The sequences of the present invention can be used to obtain such identification sequences from individuals and from tissue. The ORFX sequences of the invention uniquely represent portions of the human genome. Allelic variation occurs to some degree in the coding regions of these sequences, and to a greater degree in the noncoding regions. It is estimated that allelic variation between individual humans occurs with a frequency of about once per each 500 bases. Much of the allelic variation is due to single nucleotide polymorphisms (SNPs), which include restriction fragment length polymorphisms (RFLPs).

[0189] Each of the sequences described herein can, to some degree, be used as a standard against which DNA from an individual can be compared for identification purposes. Because greater numbers of polymorphisms occur in the noncoding regions, fewer sequences are necessary to differentiate individuals. The noncoding sequences of SEQ ID NO:2n−1 (wherein n=1 to 4534), as described above, can comfortably provide positive individual identification with a panel of perhaps 10 to 1,000 primers that each yield a noncoding amplified sequence of 100 bases. If predicted coding sequences are used, a more appropriate number of primers for positive individual identification would be 500-2,000.

[0190] Predictive Medicine

[0191] The present invention also pertains to the field of predictive medicine in which diagnostic assays, prognostic assays, pharmacogenomics, and monitoring clinical trials are used for prognostic (predictive) purposes to thereby treat an individual prophylactically. Accordingly, one aspect of the present invention relates to diagnostic assays for determining ORFX protein and/or nucleic acid expression as well as ORFX activity, in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with a disease or disorder, or is at risk of developing a disorder, associated with aberrant ORFX expression or activity. The invention also provides for prognostic (or predictive) assays for determining whether an individual is at risk of developing a disorder associated with ORFX protein, nucleic acid expression or activity. For example, mutations in a ORFX gene can be assayed in a biological sample. Such assays can be used for prognostic or predictive purpose to thereby prophylactically treat an individual prior to the onset of a disorder characterized by or associated with ORFX protein, nucleic acid expression or activity.

[0192] Another aspect of the invention provides methods for determining ORFX protein, nucleic acid expression or ORFX activity in an individual to thereby. select appropriate therapeutic or prophylactic agents for that individual (referred to herein as “pharmacogenomics”). Pharmacogenomics allows for the selection of agents (e.g., drugs) for therapeutic or prophylactic treatment of an individual based on the genotype of the individual (e.g., the genotype of the individual examined to determine the ability of the individual to respond to a particular agent.)

[0193] Yet another aspect of the invention pertains to monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of ORFX in clinical trials.

[0194] Use of Partial ORFX Sequences in Forensic Biology

[0195] DNA-based identification techniques can also be used in forensic biology. Forensic biology is a scientific field employing genetic typing of biological evidence found at a crime scene as a means for positively identifying, for example, a perpetrator of a crime. To make such an identification, PCR technology can be used to amplify DNA sequences taken from very small biological samples such as tissues, e.g., hair or skin, or body fluids, e.g., blood, saliva, or semen found at a crime scene. The amplified sequence can then be compared to a standard, thereby allowing identification of the origin of the biological sample.

[0196] The sequences of the present invention can be used to provide polynucleotide reagents, e.g., PCR primers, targeted to specific loci in the human genome, that can enhance the reliability of DNA-based forensic identifications by, for example, providing another “identification marker” (i.e. another DNA sequence that is unique to a particular individual). As mentioned above, actual base sequence information can be used for identification as an accurate alternative to patterns formed by restriction enzyme generated fragments. Sequences targeted to noncoding regions of SEQ ID NOs:_ are particularly appropriate for this use as greater numbers of polymorphisms occur in the noncoding regions, making it easier to differentiate individuals using this technique. Examples of polynucleotide reagents include the ORFX sequences or portions thereof, e.g., fragments derived from the noncoding regions of one or more of SEQ ID NO:2n−1 (where n=1 to 4534), having a length of at least 20 bases, preferably at least 30 bases.

[0197] The ORFX sequences described herein can further be used to provide polynucleotide reagents, e.g., labeled or label-able probes that can be used, for example, in an in situ hybridization technique, to identify a specific tissue, e.g., brain tissue, etc. This can be very useful in cases where a forensic pathologist is presented with a tissue of unknown origin. Panels of such ORFX probes can be used to identify tissue by species and/or by organ type.

[0198] In a similar fashion, these reagents, e.g., ORFX primers or probes can be used to screen tissue culture for contamination (i.e. screen for the presence of a mixture of different types of cells in a culture).

[0199] Predictive Medicine

[0200] The present invention also pertains to the field of predictive medicine in which diagnostic assays, prognostic assays, pharmacogenomics, and monitoring clinical trials are used for prognostic (predictive) purposes to thereby treat an individual prophylactically. Accordingly, one aspect of the present invention relates to diagnostic assays for determining ORFX protein and/or nucleic acid expression as well as ORFX activity, in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with a disease or disorder, or is at risk of developing a disorder, associated with aberrant ORFX expression or activity. The invention also provides for prognostic (or predictive) assays for determining whether an individual is at risk of developing a disorder associated with ORFX protein, nucleic acid expression or activity. For example, mutations in a ORFX gene can be assayed in a biological sample. Such assays can be used for prognostic or predictive purpose to thereby prophylactically treat an individual prior to the onset of a disorder characterized by or associated with ORFX protein, nucleic acid expression or activity.

[0201] Another aspect of the invention provides methods for determining ORFX protein, nucleic acid expression or ORFX activity in an individual to thereby select appropriate therapeutic or prophylactic agents for that individual (referred to herein as “pharmacogenomics”). Pharmacogenomics allows for the selection of agents (e.g., drugs) for therapeutic or prophylactic treatment of an individual based on the genotype of the individual (e.g., the genotype of the individual examined to determine the ability of the individual to respond to a particular agent.)

[0202] Yet another aspect of the invention pertains to monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of ORFX in clinical trials.

[0203] These and other agents are described in further detail in the following sections.

[0204] Diagnostic Assays

[0205] Other conditions in which proliferation of cells plays a role include tumors, restenosis, psoriasis, Dupuytren's contracture, diabetic complications, Kaposi's sarcoma and rheumatoid arthritis.

[0206] An ORFX polypeptide may be used to identify an interacting polypeptide a sample or tissue. The method comprises contacting the sample or tissue with ORFX, allowing formation of a complex between the ORFX polypeptide and the interacting polypeptide, and detecting the complex, if present.

[0207] The proteins of the invention may be used to stimulate production of antibodies specifically binding the proteins. Such antibodies may be used in immunodiagnostic procedures to detect the occurrence of the protein in a sample. The proteins of the invention may be used to stimulate cell growth and cell proliferation in conditions in which such growth would be favorable. An example would be to counteract toxic side effects of chemotherapeutic agents on, for example, hematopoiesis and platelet formation, linings of the gastrointestinal tract, and hair follicles. They may also be used to stimulate new cell growth in neurological disorders including, for example, Alzheimer's disease. Alternatively, antagonistic treatments may be administered in which an antibody specifically binding the ORFX-like proteins of the invention would abrogate the specific growth-inducing effects of the proteins. Such antibodies may be useful, for example, in the treatment of proliferative disorders including various tumors and benign hyperplasias.

[0208] Polynucleotides or oligonucleotides corresponding to any one portion of the ORFX nucleic acids of SEQ ID NO:2n−1 (wherein n=1 to 4534) may be used to detect DNA containing a corresponding ORF gene, or detect the expression of a corresponding ORFX gene, or ORFX-like gene. For example, an ORFX nucleic acid expressed in a particular cell or tissue, as noted in Table 2, can be used to identify the presence of that particular cell type.

[0209] An exemplary method for detecting the presence or absence of ORFX in a biological sample involves obtaining a biological sample from a test subject and contacting the biological sample with a compound or an agent capable of detecting ORFX protein or nucleic acid (e.g., mRNA, genomic DNA) that encodes ORFX protein such that the presence of ORFX is detected in the biological sample. An agent for detecting ORFX mRNA or genomic DNA is a labeled nucleic acid probe capable of hybridizing to ORFX mRNA or genomic DNA. The nucleic acid probe can be, for example, a full-length ORFX nucleic acid, such as the nucleic acid of SEQ ID NO:2n−1 (wherein n=1 to 4534), or a portion thereof, such as an oligonucleotide of at least 15, 30, 50, 100, 250 or 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to ORFX mRNA or genomic DNA, as described above. Other suitable probes for use in the diagnostic assays of the invention are described herein.

[0210] An agent for detecting ORFX protein is an antibody capable of binding to ORFX protein, preferably an antibody with a detectable label. Antibodies can be polyclonal, or more preferably, monoclonal. An intact antibody, or a fragment thereof (e.g., Fab or F(ab′)2) can be used. The term “labeled”, with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a fluorescently labeled secondary antibody and end-labeling of a DNA probe with biotin such that it can be detected with fluorescently labeled streptavidin. The term “biological sample” is intended to include tissues, cells and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject. That is, the detection method of the invention can be used to detect ORFX mRNA, protein, or genomic DNA in a biological sample in vitro as well as in vivo. For example, in vitro techniques for detection of ORFX mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detection of ORFX protein include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations and immunofluorescence. In vitro techniques for detection of ORFX genomic DNA include Southern hybridizations. Furthermore, in vivo techniques for detection of ORFX protein include introducing into a subject a labeled anti-ORFX antibody. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques.

[0211] In one embodiment, the biological sample contains protein molecules from the test subject. Alternatively, the biological sample can contain mRNA molecules from the test subject or genomic DNA molecules from the test subject. A preferred biological sample is a peripheral blood leukocyte sample isolated by conventional means from a subject.

[0212] In another embodiment, the methods further involve obtaining a control biological sample from acontrol subject, contacting the control sample with a compound or agent capable of detecting ORFX protein, mRNA, or genomic DNA, such that the presence of ORFX protein, mRNA or genomic DNA is detected in the biological sample, and comparing the presence of ORFX protein, mRNA or genomic DNA in the control sample with the presence of ORFX protein, mRNA or genomic DNA in the test sample.

[0213] The invention also encompasses kits for detecting the presence of ORFX in a biological sample. For example, the kit can comprise: a labeled compound or agent capable of detecting ORFX protein or mRNA in a biological sample; means for determining the amount of ORFX in the sample; and means for comparing the amount of ORFX in the sample with a standard. The compound or agent can be packaged in a suitable container. The kit can further comprise instructions for using the kit to detect ORFX protein or nucleic acid.

[0214] Prognostic Assays

[0215] The diagnostic methods described herein can furthermore be utilized to identify subjects having or at risk of developing a disease or disorder associated with aberrant ORFX expression or activity. For example, the assays described herein, such as the preceding diagnostic assays or the following assays, can be utilized to identify a subject having or at risk of developing a disorder associated with ORFX protein, nucleic acid expression or activity in, e.g., proliferative or differentiative disorders such as hyperplasias, tumors, restenosis, psoriasis, Dupuytren's contracture, diabetic complications, or rheumatoid arthritis, etc.; and glia-associated disorders such as cerebral lesions, diabetic neuropathies, cerebral edema, senile dementia, Alzheimer's disease, etc. Alternatively, the prognostic assays can be utilized to identify a subject having or at risk for developing a disease or disorder. Thus, the present invention provides a method for identifying a disease or disorder associated with aberrant ORFX expression or activity in which a test sample is obtained from a subject and ORFX protein or nucleic acid (e.g., mRNA, genomic DNA) is detected, wherein the presence of ORFX protein or nucleic acid is diagnostic for a subject having or at risk of developing a disease or disorder associated with aberrant ORFX expression or activity. As used herein, a “test sample” refers to a biological sample obtained from a subject of interest. For example, a test sample can be a biological fluid (e.g., serum), cell sample, or tissue.

[0216] Furthermore, the prognostic assays described herein can be used to determine whether a subject can be administered an agent (e.g., an agonist, antagonist, peptidomimetic, protein, peptide, nucleic acid, small molecule, or other drug candidate) to treat a disease or disorder associated with aberrant ORFX expression or activity. For example, such methods can be used to determine whether a subject can be effectively treated with an agent for a disorder, such as a proliferative disorder, differentiative disorder, glia-associated disorders, etc. Thus, the present invention provides methods for determining whether a subject can be effectively treated with an agent for a disorder associated with aberrant ORFX expression or activity in which a test sample is obtained and ORFX protein or nucleic acid is detected (e.g., wherein the presence of ORFX protein or nucleic acid is diagnostic for a subject that can be administered the agent to treat a disorder associated with aberrant ORFX expression or activity.)

[0217] The methods of the invention can also be used to detect genetic lesions in a ORFX gene, thereby determining if a subject with the lesioned gene is at risk for, or suffers from, a proliferative disorder, differentiative disorder, glia-associated disorder, etc. In various embodiments, the methods include detecting, in a sample of cells from the subject, the presence or absence of a genetic lesion characterized by at least one of an alteration affecting the integrity of a gene encoding a ORFX-protein, or the mis-expression of the ORFX gene. For example, such genetic lesions can be detected by ascertaining the existence of at least one of (1) a deletion of one or more nucleotides from a ORFX gene; (2) an addition of one or more nucleotides to a ORFX gene; (3) a substitution of one or more nucleotides of a ORFX gene, (4) a chromosomal rearrangement of a ORFX gene; (5) an alteration in the level of a messenger RNA transcript of a ORFX gene, (6) aberrant modification of a ORFX gene, such as of the methylation pattern of the genomic DNA, (7) the presence of a non-wild type splicing pattern of a messenger RNA transcript of a ORFX gene, (8) a non-wild type level of a ORFX-protein, (9) allelic loss of a ORFX gene, and (10) inappropriate post-translational modification of a ORFX-protein. As described herein, there are a large number of assay techniques known in the art which can be used for detecting lesions in a ORFX gene. A preferred biological sample is a peripheral blood leukocyte sample isolated by conventional means from a subject. However, any biological sample containing nucleated cells may be used, including, for example, buccal mucosal cells.

[0218] In certain embodiments, detection of the lesion involves the use of a probe/primer in a polymerase chain reaction (PCR) (see, e.g., U.S. Pat. Nos. 4,683,195 and 4,683,202), such as anchor PCR or RACE PCR, or, alternatively, in a ligation chain reaction (LCR) (see, e.g, Landegran et al. (1988) Science 241:1077-1080; and Nakazawa et al. (1994) PNAS 91:360-364), the latter of which can be particularly useful for detecting point mutations in the ORFX-gene (see Abravaya et al. (1995) Nucl Acids Res 23:675-682). This method can include the steps of collecting a sample of cells from a patient, isolating nucleic acid (e.g., genomic, mRNA or both) from the cells of the sample, contacting the nucleic acid sample with one or more primers that specifically hybridize to a ORFX gene under conditions such that hybridization and amplification of the ORFX gene (if present) occurs, and detecting the presence or absence of an amplification product, or detecting the size of the amplification product and comparing the length to a control sample. It is anticipated that PCR and/or LCR may be desirable to use as a preliminary amplification step in conjunction with any of the techniques used for detecting mutations described herein.

[0219] Alternative amplification methods include: self sustained sequence replication (Guatelli et al., 1990, Proc Natl Acad Sci USA 87:1874-1878),transcriptional amplification system (Kwoh, et al., 1989, Proc Natl Acad Sci USA 86:1173-1177), Q-Beta Replicase (Lizardi et al, 1988, BioTechnology 6:1197), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers.

[0220] In an alternative embodiment, mutations in a ORFX gene from a sample cell can be identified by alterations in restriction enzyme cleavage patterns. For example, sample and control DNA is isolated, amplified (optionally), digested with one or more restriction endonucleases, and fragment length sizes are determined by gel electrophoresis and compared. Differences in fragment length sizes between sample and control DNA indicates mutations in the sample DNA. Moreover, the use of sequence specific ribozymes (see, for example, U.S. Pat. No. 5,493,531) can be used to score for the presence of specific mutations by development or loss of a ribozyme cleavage site.

[0221] In other embodiments, genetic mutations in ORFX can be identified by hybridizing a sample and control nucleic acids, e.g., DNA or RNA, to high density arrays containing hundreds or thousands of oligonucleotides probes (Cronin et al. (1996) Human Mutation 7: 244-255; Kozal et al. (1996) Nature Medicine 2: 753-759). For example, genetic mutations in ORFX can be identified in two dimensional arrays containing light-generated DNA probes as described in Cronin et al. above. Briefly, a first hybridization array of probes can be used to scan through long stretches of DNA in a sample and control to identify base changes between the sequences by making linear arrays of sequential overlapping probes. This step allows the identification of point mutations. This step is followed by a second hybridization array that allows the characterization of specific mutations by using smaller, specialized probe arrays complementary to all variants or mutations detected. Each mutation array is composed of parallel probe sets, one complementary to the wild-type gene and the other complementary to the mutant gene.

[0222] In yet another embodiment, any of a variety of sequencing reactions known in the art can be used to directly sequence the ORFX gene and detect mutations by comparing the sequence of the sample ORFX with the corresponding wild-type (control) sequence. Examples of sequencing reactions include those based on techniques developed by Maxim and Gilbert (1977) PNAS 74:560 or Sanger (1977) PNAS 74:5463. It is also contemplated that any of a variety of automated sequencing procedures can be utilized when performing the diagnostic assays (Naeve et al., (1995) Biotechniques 19:448), including sequencing by mass spectrometry (see, e.g., PCT International Publ. No. WO 94/16101; Cohen et al. (1996) Adv Chromatogr 36:127-162; and Griffin et al. (1993) Appl Biochem Biotechnol 38:147-159).

[0223] Other methods for detecting mutations in the ORFX gene include methods in which protection from cleavage agents is used to detect mismatched bases in RNA/RNA or RNA/DNA heteroduplexes (Myers et al. (1985) Science 230:1242). In general, the art technique of “mismatch cleavage” starts by providing heteroduplexes of formed by hybridizing (labeled) RNA or DNA containing the wild-type ORFX sequence with potentially mutant RNA or DNA obtained from a tissue sample. The double-stranded duplexes are treated with an agent that cleaves single-stranded regions of the duplex such as which will exist due to basepair mismatches between the control and sample strands. For instance, RNA/DNA duplexes can be treated with RNase and DNA/DNA hybrids treated with SI nuclease to enzymatically digesting the mismatched regions. In other embodiments, either DNA/DNA or RNA/DNA duplexes can be treated with hydroxylamine or osmium tetroxide and with piperidine in order to digest mismatched regions. After digestion of the mismatched regions, the resulting material is then separated by size on denaturing polyacrylamide gels to determine the site of mutation. See, for example, Cotton et al (1988) Proc Natl Acad Sci USA 85:4397; Saleeba et al (1992) Methods Enzymol 217:286-295. In an embodiment, the control DNA or RNA can be labeled for detection.

[0224] In still another embodiment, the mismatch cleavage reaction employs one or more proteins that recognize mismatched base pairs in double-stranded DNA (so called “DNA mismatch repair” enzymes) in defined systems for detecting and mapping point mutations in ORFX cDNAs obtained from samples of cells. For example, the mutY enzyme of E. coli cleaves A at G/A mismatches and the thymidine DNA glycosylase from HeLa cells cleaves T at G/F mismatches (Hsu et al. (1994) Carcinogenesis 15:1657-1662). According to an exemplary embodiment, a probe based on a ORFX sequence, e.g., a wild-type ORFX sequence, is hybridized to a cDNA or other DNA product from a test cell(s). The duplex is treated with a DNA mismatch repair enzyme, and the cleavage products, if any, can be detected from electrophoresis protocols or the like. See, for example, U.S. Pat. No. 5,459,039.

[0225] In other embodiments, alterations in electrophoretic mobility will be used to identify mutations in ORFX genes. For example, single strand conformation polymorphism (SSCP) may be used to detect differences in electrophoretic mobility between mutant and wild type nucleic acids (Orita et al. (1989) Proc Natl Acad Sci USA: 86:2766, see also Cotton (1993) Mutat Res 285:125-144; Hayashi (1992) Genet Anal Tech Appl 9:73-79). Single-stranded DNA fragments of sample and control ORFX nucleic acids will be denatured and allowed to renature. The secondary structure of single-stranded nucleic acids varies according to sequence, the resulting alteration in electrophoretic mobility enables the detection of even a single base change. The DNA fragments may be labeled or detected with labeled probes. The sensitivity of the assay may be enhanced by using RNA, rather than DNA, in which the secondary structure is more sensitive to a change in sequence. In one embodiment, the subject method utilizes heteroduplex analysis to separate double stranded heteroduplex molecules on the basis of changes in electrophoretic mobility. See, e.g., Keen et al. (1991) Trends Genet 7:5.

[0226] In yet another embodiment the movement of mutant or wild-type fragments in polyacrylamide gels containing a gradient of denaturant is assayed using denaturing gradient gel electrophoresis (DGGE). See, e.g., Myers et al (1985) Nature 313:495. When DGGE is used as the method of analysis, DNA will be modified to insure that it does not completely denature, for example by adding a GC clamp of approximately 40 bp of high-melting GC-rich DNA by PCR. In a further embodiment, a temperature gradient is used in place of a denaturing gradient to identify differences in the mobility of control and sample DNA. See, e.g., Rosenbaum and Reissner (1987) Biophys Chem 265:12753.

[0227] Examples of other techniques for detecting point mutations include, but are not limited to, selective oligonucleotide hybridization, selective amplification, or. selective primer extension. For example, oligonucleotide primers may be prepared in which the known mutation is placed centrally and then hybridized to target DNA under conditions that permit hybridization only if a perfect match is found. See, e.g., Saiki et al. (1986) Nature 324:163); Saiki et al. (1989) Proc Natl Acad Sci USA 86:6230. Such allele specific oligonucleotides are hybridized to PCR amplified target DNA or a number of different mutations when the oligonucleotides are attached to the hybridizing membrane and hybridized with labeled target DNA.

[0228] Alternatively, allele specific amplification technology that depends on selective PCR amplification may be used in conjunction with the instant invention. Oligonucleotides used as primers for specific amplification may carry the mutation of interest in the center of the molecule (so that amplification depends on differential hybridization) (Gibbs et al. (1989) Nucleic Acids Res 17:2437-2448) or at the extreme 3′ end of one primer where, under appropriate conditions, mismatch can prevent, or reduce polymerase extension (Prossner (1993) Tibtech 11:238). In addition it may be desirable to introduce a novel restriction site in the region of the mutation to create cleavage-based detection. See, e.g., Gasparini et al (1992) Mol Cell Probes 6:1. It is anticipated that in certain embodiments amplification may also be performed using Taq ligase for amplification. See, e.g., Barany (1991) Proc Natl Acad Sci USA 88:189. In such cases, ligation will occur only if there is a perfect match at the 3′ end of the 5′ sequence, making it possible to detect the presence of a known mutation at a specific site by looking for the presence or absence of amplification.

[0229] The methods described herein may be performed, for example, by utilizing pre-packaged diagnostic kits comprising at least one probe nucleic acid or antibody reagent described herein, which may be conveniently used, e.g., in clinical settings to diagnose patients exhibiting symptoms or family history of a disease or illness involving a ORFX gene.

[0230] Furthermore, any cell type or tissue, preferably peripheral blood leukocytes, in which ORFX is expressed may be utilized in the prognostic assays described herein. However, any biological sample containing nucleated cells may be used, including, for example, buccal mucosal cells.

[0231] Pharmacogenomics

[0232] Agents, or modulators that have a stimulatory or inhibitory effect on ORFX activity (e.g., ORFX gene expression), as identified by a screening assay described herein can be administered to individuals to treat (prophylactically or therapeutically) disorders (e.g., neurological, cancer-related or gestational disorders) associated with aberrant ORFX activity. In conjunction with such treatment, the pharmacogenomics (i.e., the study of the relationship between an individual's genotype and that individual's response to a foreign compound or drug) of the individual may be considered. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Thus, the pharmacogenomics of the individual permits the selection of effective agents (e.g., drugs) for prophylactic or therapeutic treatments based on a consideration of the individual's genotype. Such pharmacogenomics can further be used to determine appropriate dosages and therapeutic regimens. Accordingly, the activity of ORFX protein, expression of ORFX nucleic acid, or mutation content of ORFX genes in an individual can be determined to thereby select appropriate agent(s) for therapeutic or prophylactic treatment of the individual.

[0233] Pharmacogenomics deals with clinically significant hereditary variations in the response to drugs due to altered drug disposition and abnormal action in affected persons. See e.g., Eichelbaum, 1996, Clin Exp Pharmacol Physiol, 23:983-985 and Linder, 1997, Clin Chem, 43:254-266. In general, two types of pharmacogenetic conditions can be differentiated. Genetic conditions transmitted as a single factor altering the way drugs act on the body (altered drug action) or genetic conditions transmitted as single factors altering the way the body acts on drugs (altered drug metabolism). These pharmacogenetic conditions can occur either as rare defects or as polymorphisms. For example, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited enzymopathy in which the main clinical complication is haemolysis after ingestion of oxidant drugs (anti-malarials, sulfonamides, analgesics, nitrofurans) and consumption of fava beans.

[0234] As an illustrative embodiment, the activity of drug metabolizing enzymes is a major determinant of both the intensity and duration of drug action. The discovery of genetic polymorphisms of drug metabolizing enzymes (e.g., N-acetyltransferase 2 (NAT 2) and cytochrome P450 enzymes CYP2D6 and CYP2C19) has provided an explanation as to why some patients do not obtain the expected drug effects or show exaggerated drug response and serious toxicity after taking the standard and safe dose of a drug. These polymorphisms are expressed in two phenotypes in the population, the extensive metabolizer (EM) and poor metabolizer (PM). The prevalence of PM is different among different populations. For example, the gene coding for CYP2D6 is highly polymorphic and several mutations have been identified in PM, which all lead to the absence of functional CYP2D6. Poor metabolizers of CYP2D6 and CYP2C19 quite frequently experience exaggerated drug response and side effects when they receive standard doses. If a metabolite is the active therapeutic moiety, PM show no therapeutic response, as demonstrated for the analgesic effect of codeine mediated by its CYP2D6-formed metabolite morphine. The other extreme are the so called ultra-rapid metabolizers who do not respond to standard doses. Recently, the molecular basis of ultra-rapid metabolism has been identified to be due to CYP2D6 gene amplification.

[0235] Thus, the activity of ORFX protein, expression of ORFX nucleic acid, or mutation content of ORFX genes in an individual can be determined to thereby select appropriate agent(s) for therapeutic or prophylactic treatment of the individual. In addition, pharmacogenetic studies can be used to apply genotyping of polymorphic alleles encoding drug-metabolizing enzymes to the identification of an individual's drug responsiveness phenotype. This knowledge, when applied to dosing or drug selection, can avoid adverse reactions or therapeutic failure and thus enhance therapeutic or prophylactic efficiency when treating a subject with a ORFX modulator, such as a modulator identified by one of the exemplary screening assays described herein.

[0236] Monitoring Clinical Efficacy

[0237] Monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of ORFX (e.g., the ability to modulate aberrant cell proliferation and/or differentiation) can be applied in basic drug screening and in clinical trials. For example, the effectiveness of an agent determined by a screening assay as described herein to increase ORFX gene expression, protein levels, or upregulate ORFX activity, can be monitored in clinical trials of subjects exhibiting decreased ORFX gene expression, protein levels, or downregulated ORFX activity. Alternatively, the effectiveness of an agent determined by a screening assay to decrease ORFX gene expression, protein levels, or downregulate ORFX activity, can be monitored in clinical trials of subjects exhibiting increased ORFX gene expression, protein levels, or upregulated ORFX activity. In such clinical trials, the expression or activity of ORFX and, preferably, other genes that have been implicated in, for example, a proliferative or neurological disorder, can be used as a “read out” or marker of the responsiveness of a particular cell.

[0238] For example, genes, including ORFX, that are modulated in cells by treatment with an agent (e.g., compound, drug or small molecule) that modulates ORFX activity (e.g., identified in a screening assay as described herein) can be identified. Thus, to study the effect of agents on cellular proliferation disorders, for example, in a clinical trial, cells can be isolated and RNA prepared and analyzed for the levels of expression of ORFX and other genes implicated in the disorder. The levels of gene expression (i.e., a gene expression pattern) can be quantified by Northern blot analysis or RT-PCR, as described herein, or alternatively by measuring the amount of protein produced, by one of the methods as described herein, or by measuring the levels of activity of ORFX or other genes. In this way, the gene expression pattern can serve as a marker, indicative of the physiological response of the cells to the agent. Accordingly, this response state may be determined before, and at various points during, treatment of the individual with the agent.

[0239] In one embodiment, the invention provides a method for monitoring the effectiveness of treatment of a subject with an agent (e.g., an agonist, antagonist, protein, peptide, nucleic acid, peptidomimetic, small molecule, or other drug candidate identified by the screening assays described herein) comprising the steps of (i) obtaining a pre-administration sample from a subject prior to administration of the agent; (ii) detecting the level of expression of a ORFX protein, mRNA, or genomic DNA in the preadministration sample; (iii) obtaining one or more post-administration samples from the subject; (iv) detecting the level of expression or activity of the ORFX protein, mRNA, or genomic DNA in the post-administration samples; (v) comparing the level of expression or activity of the ORFX protein, mRNA, or genomic DNA in the pre-administration sample with the ORFX protein, mRNA, or genomic DNA in the post administration sample or samples; and (vi) altering the administration of the agent to the subject accordingly. For example, increased administration of the agent may be desirable to increase the expression or activity of ORFX to higher levels than detected, i.e., to increase the effectiveness of the agent. Alternatively, decreased administration of the agent may be desirable to decrease expression or activity of ORFX to lower levels than detected, i.e., to decrease the effectiveness of the agent.

[0240] Methods of Treatment

[0241] The present invention provides for both prophylactic and therapeutic methods of treating a subject at risk of (or susceptible to) a disorder or having a disorder associated with aberrant ORFX expression or activity.

[0242] Diseases and disorders that are characterized by increased (relative to a subject not suffering from the disease or disorder) levels or biological activity may be treated with Therapeutics that antagonize (i.e., reduce or inhibit) activity. Therapeutics that antagonize activity may be administered in a therapeutic or prophylactic manner. Therapeutics that may be utilized include, but are not limited to, (i) a ORFX polypeptide, or analogs, derivatives, fragments or homologs thereof; (it) antibodies to a ORFX peptide; (iii) nucleic acids encoding a ORFX peptide; (iv) administration of antisense nucleic acid and nucleic acids that are “dysfunctional” (i.e., due to a heterologous insertion within the coding sequences of coding sequences to a ORFX peptide) that are utilized to “knockout” endogenous function of a ORFX peptide by homologous recombination (see, e.g., Capecchi, 1989, Science 244: 1288-1292); or (v) modulators (i.e., inhibitors, agonists and antagonists, including additional peptide mimetic of the invention or antibodies specific to a peptide of the invention) that alter the interaction between a ORFX peptide and its binding partner.

[0243] Diseases and disorders that are characterized by decreased (relative to a subject not suffering from the disease or disorder) levels or biological activity may be treated with Therapeutics that increase (i.e., are agonists to) activity. Therapeutics that upregulate activity may be administered in a therapeutic or prophylactic manner. Therapeutics that may be utilized include, but are not limited to, a ORFX peptide, or analogs, derivatives, fragments or homologs thereof; or an agonist that increases bioavailability.

[0244] Increased or decreased levels can be readily detected by quantifying peptide and/or RNA, by obtaining a patient tissue sample (e.g., from biopsy tissue) and assaying it in vitro for RNA or peptide levels, structure and/or activity of the expressed peptides (or mRNAs of a ORFX peptide). Methods that are well-known within the art include, but are not limited to, immunoassays (e.g., by Western blot analysis, immunoprecipitation followed by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, immunocytochemistry, etc.) and/or hybridization assays to detect expression of mRNAs (e.g., Northern assays, dot blots, in situ hybridization, etc.).

[0245] In one aspect, the invention provides a method for preventing, in a subject, a disease or condition associated with an aberrant ORFX expression or activity, by administering to the subject an agent that modulates ORFX expression or at least one ORFX activity. Subjects at risk for a disease that is caused or contributed to by aberrant ORFX expression or activity can be identified by, for example, any or a combination of diagnostic or prognostic assays as described herein. Administration of a prophylactic agent can occur prior to the manifestation of symptoms characteristic of the ORFX aberrancy, such that a disease or disorder is prevented or, alternatively, delayed in its progression. Depending on the type of ORFX aberrancy, for example, a ORFX agonist or ORFX antagonist agent can be used for treating the subject. The appropriate agent can be determined based on screening assays described herein.

[0246] Another aspect of the invention pertains to methods of modulating ORFX expression or activity for therapeutic purposes. The modulatory method of the invention involves contacting a cell with an agent that modulates one or more of the activities of ORFX protein activity associated with the cell. An agent that modulates ORFX protein activity can be an agent as described herein, such as a nucleic acid or a protein, a naturally-occurring cognate ligand of a ORFX protein, a peptide, a ORFX peptidomimetic, or other small molecule. In one embodiment, the agent stimulates one or more ORFX protein activity. Examples of such stimulatory agents include active ORFX protein and a nucleic acid molecule encoding ORFX that has been introduced into the cell. In another embodiment, the agent inhibits one or more ORFX protein activity. Examples of such inhibitory agents include antisense ORFX nucleic acid molecules and anti-ORFX antibodies. These modulatory methods can be performed in vitro (e.g., by culturing the cell with the agent) or, alternatively, in vivo (e.g., by administering the agent to a subject). As such, the present invention provides methods of treating an individual afflicted with a disease or disorder characterized by aberrant expression or activity of a ORFX protein or nucleic acid molecule. In one embodiment, the method involves administering an agent (e.g., an agent identified by a screening assay described herein), or combination of agents that modulates (e.g., upregulates or downregulates) ORFX expression or activity. In another embodiment, the method involves administering a ORFX protein or nucleic acid molecule as therapy to compensate for reduced or aberrant ORFX expression or activity.

[0247] Determination of the Biological Effect of a Therapeutic

[0248] In various embodiments of the present invention, suitable in vitro or in vivo assays are utilized to determine the effect of a specific Therapeutic and whether its administration is indicated for treatment of the affected tissue.

[0249] In various specific embodiments, in vitro assays may be performed with representative cells of the type(s) involved in the patient's disorder, to determine if a given Therapeutic exerts the desired effect upon the cell type(s). Compounds for use in therapy may be tested in suitable animal model systems including, but not limited to rats, mice, chicken, cows, monkeys, rabbits, and the like, prior to testing in human subjects. Similarly, for in vivo testing, any of the animal model system known in the art may be used prior to administration to human subjects.

[0250] Malignancies

[0251] Some ORFX polypeptides are expressed in cancerous cells (see, e.g., Tables 1 and 2). Accordingly, the corresponding ORF protein is involved in the regulation of cell proliferation. Accordingly, Therapeutics of the present invention may be useful in the therapeutic or prophylactic treatment of diseases or disorders that are associated with cell hyperproliferation and/or loss of control of cell proliferation (e.g., cancers, malignancies and tumors). For a review of such hyperproliferation disorders, see e.g., Fishman, et al., 1985. Medicine 2nd ed., J. B. Lippincott Co., Philadelphia, Pa.

[0252] Therapeutics of the present invention may be assayed by any method known within the art for efficacy in treating or preventing malignancies and related disorders. Such assays include, but are not limited to, in vitro assays utilizing transformed cells or cells derived from the patient's tumor, as well as in vivo assays using animal models of cancer or malignancies. Potentially effective Therapeutics are those that, for example, inhibit the proliferation of tumor-derived or transformed cells in culture or cause a regression of tumors in animal models, in comparison to the controls.

[0253] In the practice of the present invention, once a malignancy or cancer has been shown to be amenable to treatment by modulating (i.e., inhibiting, antagonizing or agonizing) activity, that cancer or malignancy may subsequently be treated or prevented by the administration of a Therapeutic that serves to modulate protein function.

[0254] Premalignant Conditions

[0255] The Therapeutics of the present invention that are effective in the therapeutic or prophylactic treatment of cancer or malignancies may also be administered for the treatment of pre-malignant conditions and/or to prevent the progression of a pre-malignancy to a neoplastic or malignant state. Such prophylactic or therapeutic use is indicated in conditions known or suspected of preceding progression to neoplasia or cancer, in particular, where non-neoplastic cell growth consisting of hyperplasia, metaplasia or, most particularly, dysplasia has occurred. For a review of such abnormal cell growth see e.g., Robbins & Angell, 1976. Basic Pathology, 2nd ed., W. B. Saunders Co., Philadelphia, Pa.

[0256] Hyperplasia is a form of controlled cell proliferation involving an increase in cell number in a tissue or organ, without significant alteration in its structure or function. For example, it has been demonstrated that endometrial hyperplasia often precedes endometrial cancer. Metaplasia is a form of controlled cell growth in which one type of mature or fully differentiated cell substitutes for another type of mature cell. Metaplasia may occur in epithelial or connective tissue cells. Dysplasia is generally considered a precursor of cancer, and is found mainly in the epithelia. Dysplasia is the most disorderly form of non-neoplastic cell growth, and involves a loss in individual cell uniformity and in the architectural orientation of cells. Dysplasia characteristically occurs where there exists chronic irritation or inflammation, and is often found in the cervix, respiratory passages, oral cavity, and gall bladder.

[0257] Alternatively, or in addition to the presence of abnormal cell growth characterized as hyperplasia, metaplasia, or dysplasia, the presence of one or more characteristics of a transformed or malignant phenotype displayed either in vivo or in vitro within a cell sample derived from a patient, is indicative of the desirability of prophylactic/therapeutic administration of a Therapeutic that possesses the ability to modulate activity of An aforementioned protein. Characteristics of a transformed phenotype include, but are not limited to: (i) morphological changes; (ii) looser substratum attachment; (iii) loss of cell-to-cell contact inhibition; (iv) loss of anchorage dependence; (v) protease release; (vi) increased sugar transport; (vii) decreased serum requirement; (viii) expression of fetal antigens, (ix) disappearance of the 250 kDal cell-surface protein, and the like. See e.g., Richards, et al., 1986. Molecular Pathology, W. B. Saunders Co., Philadelphia, Pa.

[0258] In a specific embodiment of the present invention, a patient that exhibits one or more of the following predisposing factors for malignancy is treated by administration of an effective amount of a Therapeutic: (i) a chromosomal translocation associated with a malignancy (e.g., the Philadelphia chromosome (bcr/abl) for chronic myelogenous leukemia and t(14;18) for follicular lymphoma, etc.); (ii) familial polyposis or Gardner's syndrome (possible forerunners of colon cancer); (iii) monoclonal gammopathy of undetermined significance (a possible precursor of multiple myeloma) and (iv) a first degree kinship with persons having a cancer or pre-cancerous disease showing a Mendelian (genetic) inheritance pattern (e.g., familial polyposis of the colon, Gardner's syndrome, hereditary exostosis, polyendocrine adenomatosis, Peutz-Jeghers syndrome, neurofibromatosis of Von Recklinghausen, medullary thyroid carcinoma with amyloid production and pheochromocytoma, retinoblastoma, carotid body tumor, cutaneous melanocarcinoma, intraocular melanocarcinoma, xeroderma pigmentosum, ataxia telangiectasia, Chediak-Higashi syndrome, albinism, Fanconi's aplastic anemia and Bloom's syndrome).

[0259] In another embodiment, a Therapeutic of the present invention is administered to a human patient to prevent the progression to breast, colon, lung, pancreatic, or uterine cancer, or melanoma or sarcoma.

[0260] Hyperproliferative and Dysproliferative Disorders

[0261] In one embodiment of the present invention, a Therapeutic is administered in the therapeutic or prophylactic treatment of hyperproliferative or benign dysproliferative disorders. The efficacy in treating or preventing hyperproliferative diseases or disorders of a Therapeutic of the present invention may be assayed by any method known within the art. Such assays include in vitro cell proliferation assays, in vitro or in vivo assays using animal models of hyperproliferative diseases or disorders, or the like. Potentially effective Therapeutics may, for example, promote cell proliferation in culture or cause growth or cell proliferation in animal models in comparison to controls.

[0262] Specific embodiments of the present invention are directed to the treatment or prevention of cirrhosis of the liver (a condition in which scarring has overtaken normal liver regeneration processes); treatment of keloid (hypertrophic scar) formation causing disfiguring of the skin in which the scarring process interferes with normal renewal; psoriasis (a common skin condition characterized by excessive proliferation of the skin and delay in proper cell fate determination); benign tumors; fibrocystic conditions and tissue hypertrophy (e.g., benign prostatic hypertrophy).

[0263] Neurodegenerative Disorders

[0264] Some ORFX proteins are found in cell types have been implicated in the deregulation of cellular maturation and apoptosis, which are both characteristic of neurodegenerative disease. Accordingly, Therapeutics of the invention, particularly but not limited to those that modulate (or supply) activity of an aforementioned protein, may be effective in treating or preventing neurodegenerative disease. Therapeutics of the present invention that modulate the activity of an aforementioned protein involved in neurodegenerative disorders can be assayed by any method known in the art for efficacy in treating or preventing such neurodegenerative diseases and disorders. Such assays include in vitro assays for regulated cell maturation or inhibition of apoptosis or in vivo assays using animal models of neurodegenerative diseases or disorders, or any of the assays described below. Potentially effective Therapeutics, for example but not by way of limitation, promote regulated cell maturation and prevent cell apoptosis in culture, or reduce neurodegeneration in animal models in comparison to controls.

[0265] Once a neurodegenerative disease or disorder has been shown to be amenable to treatment by modulation activity, that neurodegenerative disease or disorder can be treated or prevented by administration of a Therapeutic that modulates activity. Such diseases include all degenerative disorders involved with aging, especially osteoarthritis and neurodegenerative disorders.

[0266] Disorders Related to Organ Transplantation

[0267] Some ORFX can be associated with disorders related to organ transplantation, in particular but not limited to organ rejection. Therapeutics of the invention, particularly those that modulate (or supply) activity, may be effective in treating or preventing diseases or disorders related to organ transplantation. Therapeutics of the invention (particularly Therapeutics that modulate the levels or activity of an aforementioned protein) can be assayed by any method known in the art for efficacy in treating or preventing such diseases and disorders related to organ transplantation. Such assays include in vitro assays for using cell culture models as described below, or in vivo assays using animal models of diseases and disorders related to organ transplantation, see e.g., below. Potentially effective Therapeutics, for example but not by way of limitation, reduce immune rejection responses in animal models in comparison to controls.

[0268] Accordingly, once diseases and disorders related to organ transplantation are shown to be amenable to treatment by modulation of activity, such diseases or disorders can be treated or prevented by administration of a Therapeutic that modulates activity.

[0269] Cardiovascular Disease

[0270] GENX has been implicated in cardiovascular disorders, including in atherosclerotic plaque formation. Diseases such as cardiovascular disease, including cerebral thrombosis or hemorrhage, ischemic heart or renal disease, peripheral vascular disease, or thrombosis of other major vessel, and other diseases, including diabetes mellitus, hypertension, hypothyroidism, cholesterol ester storage disease, systemic lupus erythematosus, homocysteinemia, and familial protein or lipid processing diseases, and the like, are either directly or indirectly associated with atherosclerosis. Accordingly, Therapeutics of the invention, particularly those that modulate (or supply) activity or formation may be effective in treating or preventing atherosclerosis-associated diseases or disorders. Therapeutics of the invention (particularly Therapeutics that modulate the levels or activity) can be assayed by any method known in the art, including those described below, for efficacy in treating or preventing such diseases and disorders.

[0271] A vast array of animal and cell culture models exist for processes involved in atherosclerosis. A limited and non-exclusive list of animal models includes knockout mice for premature atherosclerosis (Kurabayashi and Yazaki, 1996, Int. Angiol. 15: 187-194), transgenic mouse models of atherosclerosis (Kappel et al., 1994, FASEB J. 8: 583-592), antisense oligonucleotide treatment of animal models (Callow, 1995, Curr. Opin. Cardiol. 10: 569-576), transgenic rabbit models for atherosclerosis (Taylor, 1997, Ann. N.Y. Acad. Sci 811: 146-152), hypercholesterolemic animal models (Rosenfeld, 1996, Diabetes Res. Clin. Pract. 30 Suppl.: 1-11), hyperlipidemic mice (Paigen et al., 1994, Curr. Opin. Lipidol. 5: 258-264), and inhibition of lipoxygenase in animals (Sigal et al., 1994, Ann. N.Y. Acad. Sci. 714: 211-224). In addition, in vitro cell models include but are not limited to monocytes exposed to low density lipoprotein (Frostegard et al., 1996, Atherosclerosis 121: 93-103), cloned vascular smooth muscle cells (Suttles et al., 1995, Exp. Cell Res. 218: 331-338), endothelial cell-derived chemoattractant exposed T cells (Katz et al., 1994, J. Leukoc. Biol. 55: 567-573), cultured human aortic endothelial cells (Farber et al., 1992, Am. J. Physiol. 262: H1088-1085), and foam cell cultures (Libby et al., 1996, Curr Opin Lipidol 7: 330-335). Potentially effective Therapeutics, for example but not by way of limitation, reduce foam cell formation in cell culture models, or reduce atherosclerotic plaque formation in hypercholesterolemic mouse models of atherosclerosis in comparison to controls.

[0272] Accordingly, once an atherosclerosis-associated disease or disorder has been shown to be amenable to treatment by modulation of activity or formation, that disease or disorder can be treated or prevented by administration of a Therapeutic that modulates activity.

[0273] Cytokine and Cell Proliferation/Differentiation Activity

[0274] A GENX protein of the present invention may exhibit cytokine, cell proliferation (either inducing or inhibiting) or cell differentiation (either inducing or inhibiting) activity or may induce production of other cytokines in certain cell populations. Many protein factors discovered to date, including all known cytokines, have exhibited activity in one or more factor dependent cell proliferation assays, and hence the assays serve as a convenient confirmation of cytokine activity. The activity of a protein of the present invention is evidenced by any one of a number of routine factor dependent cell proliferation assays for cell lines including, without limitation, 32D, DA2, DA1G, T10, B9, B9/11, BaF3, MC9/G, M+(preB M+), 2E8, RB5, DA1, 123, T1165, HT2, CTLL2, TF-1, Mo7e and CMK.

[0275] The activity of a protein of the invention may, among other means, be measured by the following methods: Assays for T-cell or thymocyte proliferation include without limitation those described in: Current Protocols in Immunology, Ed by Coligan et al., Greene Publishing Associates and Wiley-Interscience (Chapter 3 and Chapter 7); Takai et al, J Immunol 137:3494-3500, 1986; Bertagnoili et al., J Immunol 145:1706-1712, 1990; Bertagnolli et al., Cell Immunol 133:327-341, 1991; Bertagnolli, et al., J Immunol 149:3778-3783, 1992; Bowman et al., J Immunol 152:1756-1761, 1994.

[0276] Assays for cytokine production and/or proliferation of spleen cells, lymph node cells or thymocytes include, without limitation,those described by Kruisbeek and Shevach, In: Current Protocols in Immunology. Coligan et al., eds. Vol 1, pp. 3.12.1-14, John Wiley and Sons, Toronto 1994; and by Schreiber, In: Current Protocols in Immunology. Coligan eds. Vol 1 pp. 6.8.1-8, John Wiley and Sons, Toronto 1994.

[0277] Assays for proliferation and differentiation of hematopoietic and lymphopoietic cells include, without limitation, those described by Bottomly et al., In: Current Protocols in Immunology. Coligan et al., eds. Vol 1 pp. 6.3.1-6.3.12, John Wiley and Sons, Toronto 1991; deVries et al., J Exp Med 173:1205-1211, 1991; Moreau et al., Nature 336:690-692, 1988; Greenberger et al., Proc Natl Acad Sci U.S.A. 80:2931-2938, 1983; Nordan, In: Current Protocols in Immunology. Coligan et al., eds. Vol 1 pp. 6.6.1-5, John Wiley and Sons, Toronto 1991; Smith et al., Proc Natl Acad Sci U.S.A. 83:1857-1861, 1986; Measurement of human Interleukin 11-Bennett, et al. In: Current Protocols in Immunology. Coligan et al., eds. Vol 1 pp. 6.15.1 John Wiley and Sons, Toronto 1991; Ciarletta, et al., In: Current Protocols in Immunology. Coligan et al., eds. Vol 1 pp. 6.13.1, John Wiley and Sons, Toronto 1991.

[0278] Assays for T-cell clone responses to antigens (which will identify, among others, proteins that affect APC-T cell interactions as well as direct T-cell effects by measuring proliferation and cytokine production) include, without limitation, those described In: Current Protocols in Immunology. Coligan et al., eds., Greene Publishing Associates and Wiley-Interscience (Chapter 3Chapter 6, Chapter 7); Weinberger et al., Proc Natl Acad Sci USA 77:6091-6095, 1980; Weinberger et al., Eur J Immun 11:405-411, 1981; Takai et al., J Immunol 137:3494-3500, 1986; Takai et al., J Immunol 140:508-512, 1988.

[0279] Immune Stimulating or Suppressing Activity

[0280] A GENX protein of the present invention may also exhibit immune stimulating or immune suppressing activity, including without limitation the activities for which assays are described herein. A protein may be useful in the treatment of various immune deficiencies and disorders (including severe combined immunodeficiency (SCID)), e.g., in regulating (up or down) growth and proliferation of T and/or B lymphocytes, as well as effecting the cytolytic activity of NK cells and other cell populations. These immune deficiencies may be genetic or be caused by vital (e.g., HIV) as well as bacterial or fungal infections, or may result from autoimmune disorders. More specifically, infectious diseases causes by vital, bacterial, fungal or other infection may be treatable using a protein of the present invention, including infections by HIV, hepatitis viruses, herpesviruses, mycobacteria, Leishmania species., malaria species. and various fungal infections such as candidiasis. Of course, in this regard, a protein of the present invention may also be useful where a boost to the immune system generally may be desirable, i.e., in the treatment of cancer.

[0281] Autoimmune disorders which may be treated using a protein of the present invention include, for example, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes mellitus, myasthenia gravis, graft-versus-host disease and autoimmune inflammatory eye disease. Such a protein of the present invention may also to be useful in the treatment of allergic reactions and conditions, such as asthma (particularly allergic asthma) or other respiratory problems. Other conditions, in which immune suppression is desired (including, for example, organ transplantation), may also be treatable using a protein of the present invention.

[0282] Using the proteins of the invention it may also be possible to immune responses, in a number of ways. Down regulation may be in the form of inhibiting or blocking an immune response already in progress or may involve preventing the induction of an immune response. The functions of activated T cells may be inhibited by suppressing T cell responses or by inducing specific tolerance in T cells, or both. Immunosuppression of T cell responses is generally an active, non-antigen-specific, process which requires continuous exposure of the T cells to the suppressive agent. Tolerance, which involves inducing non-responsiveness or energy in T cells, is distinguishable from immunosuppression in that it is generally antigen-specific and persists after exposure to the tolerizing agent has ceased. Operationally, tolerance can be demonstrated by the lack of a T cell response upon re-exposure to specific antigen in the absence of the tolerizing agent.

[0283] Down regulating or preventing one or more antigen functions (including without limitation B lymphocyte antigen functions (such as, for example, B7), e.g., preventing high level lymphokine synthesis by activated T cells, will be useful in situations of tissue, skin and organ transplantation and in graft-versus-host disease (GVHD). For example, blockage of T cell function should result in reduced tissue destruction in tissue transplantation. Typically, in tissue transplants, rejection of the transplant is initiated through its recognition as foreign by T cells, followed by an immune reaction that destroys the transplant. The administration of a molecule which inhibits or blocks interaction of a B7 lymphocyte antigen with its natural ligand(s) on immune cells (such as a soluble, monomeric form of a peptide having B7-2 activity alone or in conjunction with a monomeric form of a peptide having an activity of another B lymphocyte antigen (e.g., B7-1, B7-3) or blocking antibody), prior to transplantation can lead to the binding of the molecule to the natural ligand(s) on the immune cells without transmitting the corresponding costimulatory signal. Blocking B lymphocyte antigen function in this matter prevents cytokine synthesis by immune cells, such as T cells, and thus acts as an immunosuppressant. Moreover, the lack of costimulation may also be sufficient to energize the T cells, thereby inducing tolerance in a subject. Induction of long-term tolerance by B lymphocyte antigen-blocking reagents may avoid the necessity of repeated administration of these blocking reagents. To achieve sufficient immunosuppression or tolerance in a subject, it may also be necessary to block the function of B lymphocyte antigens.

[0284] The efficacy of particular blocking reagents in preventing organ transplant rejection or GVHD can be assessed using animal models that are predictive of efficacy in humans. Examples of appropriate systems which can be used include allogeneic cardiac grafts in rats and xenogeneic pancreatic islet cell grafts in mice, both of which have been used to examine the immunosuppressive effects of CTLA4Ig fusion proteins in vivo as described in Lenschow et al., Science 257:789-792 (1992) and Turka et al., Proc Natl Acad Sci USA, 89:11102-11105 (1992). In addition, murine models of GVHD (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 846-847) can be used to determine the effect of blocking B lymphocyte antigen function in vivo on the development of that disease.

[0285] Blocking antigen function may also be therapeutically useful for treating autoimmune diseases. Many autoimmune disorders are the result of inappropriate activation of T cells that are reactive against self tissue and which promote the production of cytokines and auto-antibodies involved in the pathology of the diseases. Preventing the activation of autoreactive T cells may reduce or eliminate disease symptoms. Administration of reagents which block costimulation of T cells by disrupting receptor:ligand interactions of B lymphocyte antigens can be used to inhibit T cell activation and prevent production of auto-antibodies or T cell-derived cytokines which may be involved in the disease process. Additionally, blocking reagents may induce antigen-specific tolerance of autoreactive T cells which could lead to long-term relief from the disease. The efficacy of blocking reagents in preventing or alleviating autoimmune disorders can be determined using a number of well-characterized animal models of human autoimmune diseases. Examples include murine experimental autoimmune encephalitis, systemic lupus erythematosis in MRL/lpr/lpr mice or NZB hybrid mice, murine autoimmune collagen arthritis, diabetes mellitus in NOD mice and BB rats, and murine experimental myasthenia gravis (see Paul ed., Fundamental Immunology Raven Press, New York, 1989, pp. 840-856).

[0286] Upregulation of an antigen function (preferably a B lymphocyte antigen function), as a means of up regulating immune responses, may also be useful in therapy. Upregulation of immune responses may be in the form of enhancing an existing immune response or eliciting an initial immune response. For example, enhancing an immune response through stimulating B lymphocyte antigen function may be useful in cases of viral infection. In addition, systemic vital diseases such as influenza, the common cold, and encephalitis might be alleviated by the administration of stimulatory forms of B lymphocyte antigens systemically.

[0287] Alternatively, anti-viral immune responses may be enhanced in an infected patient by removing T cells from the patient, costimulating the T cells in vitro with viral antigen-pulsed APCs either expressing a peptide of the present invention or together with a stimulatory form of a soluble peptide of the present invention and reintroducing the in vitro activated T cells into the patient. Another method of enhancing anti-vital immune responses would be to isolate infected cells from a patient, transfect them with a nucleic acid encoding a protein of the present invention as described herein such that the cells express all or a portion of the protein on their surface, and reintroduce the transfected cells into the patient. The infected cells would now be capable of delivering a costimulatory signal to, and thereby activate, T cells in vivo.

[0288] In another application, up regulation or enhancement of antigen function (preferably B lymphocyte antigen function) may be useful in the induction of tumor immunity. Tumor cells (e.g., sarcoma, melanoma, lymphoma, leukemia, neuroblastoma, carcinoma) transfected with a nucleic acid encoding at least one peptide of the present invention can be administered to a subject to overcome tumor-specific tolerance in the. subject. If desired, the tumor cell can be transfected to express a combination of peptides. For example, tumor cells obtained from a patient can be transfected ex vivo with an expression vector directing the expression of a peptide having B7-2-like activity alone, or in conjunction with a peptide having B7-1-like activity and/or B7-3-like activity. The transfected tumor cells are returned to the patient to result in expression of the peptides on the surface of the transfected cell. Alternatively, gene therapy techniques can be used to target a tumor cell for transfection in vivo.

[0289] The presence of the peptide of the present invention having the activity of a B lymphocyte antigen(s) on the surface of the tumor cell provides the necessary costimulation signal to T cells to induce a T cell mediated immune response against the transfected tumor cells. In addition, tumor cells which lack MHC class I or MHC class II molecules, or which fail to reexpress sufficient amounts of MHC class I or MHC class II molecules, can be transfected with nucleic acid encoding all or a portion of (e.g., a cytoplasmic-domain truncated portion) of an MHC class I α chain protein and β2 microglobulin protein or an MHC class II a chain protein and an MHC class II β chain protein to thereby express MHC class I or MHC class II proteins on the cell surface. Expression of the appropriate class I or class II MHC in conjunction with a peptide having the activity of a B lymphocyte antigen (e.g., B7-1, B7-2, B7-3) induces a T cell mediated immune response against the transfected tumor cell. Optionally, a gene encoding an antisense construct which blocks expression of an MHC class II associated protein, such as the invariant chain, can also be cotransfected with a DNA encoding a peptide having the activity of a B lymphocyte antigen to promote presentation of tumor associated antigens and induce tumor specific immunity. Thus, the induction of a T cell mediated immune response in a human subject may be sufficient to overcome tumor-specific tolerance in the subject.

[0290] The activity of a protein of the invention may, among other means, be measured by the following methods: Suitable assays for thymocyte or splenocyte cytotoxicity include, without limitation, those described In: Current Protocols in Immunology. Coligan et al., eds. Greene Publishing Associates and Wiley-Interscience (Chapter 3, Chapter 7); Herrmann et al., Proc Natl Acad Sci USA 78:2488-2492, 1981; Herrmann et al., J Immunol 128:1968-1974, 1982; Handa et al., J Immunol 135:1564-1572, 1985; Takai et al., J Immunol 137:3494-3500, 1986; Takai et al., J Immunol 140:508-512, 1988; Herrmann et al., Proc Natl Acad Sci USA 78:2488-2492, 1981; Herrmann et al., J Immunol 128:1968-1974, 1982; Handa et al., J Immunol 135:1564-1572, 1985; Takai et al., J Immunol 137:3494-3500, 1986; Bowman et al., J Virology 61:1992-1998; Takai et al, J Immunol 140:508-512, 1988; Bertagnolli et al., Cell Immunol 133:327-341, 1991; Brown et al., J Immunol 153:3079-3092, 1994.

[0291] Assays for T-cell-dependent immunoglobulin responses and isotype switching (which will identify, among others, proteins that modulate T-cell dependent antibody,responses and that affect Th1/Th2 profiles) include, without limitation, those described in: Maliszewski, J Immunol 144:3028-3033, 1990; and Mond and Brunswick In: Current Protocols in Immunology. Coligan et al., (eds.) Vol 1 pp. 3.8.1-3.8.16, John Wiley and Sons, Toronto 1994.

[0292] Mixed lymphocyte reaction (MLR) assays (which will identify, among others, proteins that generate predominantly Th1 and CTL responses) include, without limitation, those described In: Current Protocols in Immunology. Coligan et al., eds. Greene Publishing Associates and Wiley-Interscience (Chapter 3, Chapter 7); Takai et al., J Immunol 137:3494-3500, 1986; Takai et al., J Immunol 140:508-512, 1988; Bertagnolli et al., J Immunol 149:3778-3783, 1992.

[0293] Dendritic cell-dependent assays (which will identify, among others, proteins expressed by dendritic cells that activate naive T-cells) include, without limitation, those described in: Guery et al., J Immunol 134:536-544, 1995; Inaba et al, J Exp Med 173:549-559, 1991; Macatonia et al., J Immunol 154:5071-5079, 1995; Porgador et al, J Exp Med 182:255-260, 1995; Nair et al, J Virol 67:4062-4069, 1993; Huang et al., Science 264:961-965, 1994; Macatonia et al., J Exp Med 169:1255-1264, 1989; Bhardwaj et al, J Clin Investig 94:797-807, 1994; and Inaba et al., J Exp Med 172:631-640, 1990.

[0294] Assays for lymphocyte survival/apoptosis (which will identify, among others, proteins that prevent apoptosis after superantigen induction and proteins that regulate lymphocyte homeostasis) include, without limitation, those described in: Darzynkiewicz et al., Cytometry 13:795-808, 1992; Gorczyca et al., Leukemia 7:659-670, 1993; Gorczyca et al., Cancer Res 53:1945-1951, 1993; Itoh et al., Cell 66:233-243, 1991; Zacharchuk J Immunol 145:4037-4045, 1990; Zamai et al., Cytometry 14:891-897, 1993; Gorczyca et al., Internat J Oncol 1:639-648, 1992.

[0295] Assays for proteins that influence early steps of T-cell commitment and development include, without limitation, those described in: Antica et al, Blood 84:111-117, 1994; Fine et al., Cell Immunol 155: 111-122, 1994; Galy et al., Blood 85:2770-2778, 1995; Toki et al., Proc Nat Acad Sci USA 88:7548-7551, 1991.

[0296] Hematopoiesis Regulating Activity

[0297] A GENX protein of the present invention may be useful in regulation of hematopoiesis and, consequently, in the treatment of myeloid or lymphoid cell deficiencies. Even marginal biological activity in support of colony forming cells or of factor-dependent cell lines indicates involvement in regulating hematopoiesis, e.g. in supporting the growth and proliferation of erythroid progenitor cells alone or in combination with other cytokines, thereby indicating utility, for example, in treating various anemias or for use in conjunction with irradiation/chemotherapy to stimulate the production of erythroid precursors and/or erythroid cells; in supporting the growth and proliferation of myeloid cells such as granulocytes and monocytes/macrophages (i.e., traditional CSF activity) useful, for example, in conjunction with chemotherapy to prevent or treat consequent myelo-suppression; in supporting the growth and proliferation of megakaryocytes and consequently of platelets thereby allowing prevention or treatment of various platelet disorders such as thrombocytopenia, and generally for use in place of or complimentary to platelet transfusions; and/or in supporting the growth and proliferation of hematopoietic stem cells which are capable of maturing to any and all of the above-mentioned hematopoietic cells and therefore find therapeutic utility in various stem cell disorders (such as those usually treated with transplantation, including, without limitation, aplastic anemia and paroxysmal nocturnal hemoglobinuria), as well as in repopulating the stem cell compartment post irradiation/chemotherapy, either in-vivo or ex-vivo (i.e., in conjunction with bone marrow transplantation or with peripheral progenitor cell transplantation (homologous or heterologous)) as normal cells or genetically manipulated for gene therapy.

[0298] The activity of a protein of the invention may, among other means, be measured by the following methods:

[0299] Suitable assays for proliferation and differentiation of various hematopoietic lines are cited above.

[0300] Assays for embryonic stem cell differentiation (which will identify, among others, proteins that influence embryonic differentiation hematopoiesis) include, without limitation, those described in: Johansson et al. Cellular Biology 15:141-151, 1995; Keller et al., Mol. Cell. Biol. 13:473-486, 1993; McClanahan et al., Blood 81:2903-2915, 1993.

[0301] Assays for stem cell survival and differentiation (which will identify, among others, proteins that regulate lympho-hematopoiesis) include, without limitation, those described in: Methylcellulose colony forming assays, Freshney, In: Culture of Hematopoietic Cells. Freshney, et al. (eds.) Vol pp. 265-268, Wiley-Liss, Inc., New York, N.Y. 1994; Hirayama et al., Proc Natl Acad Sci USA 89:5907-5911, 1992; McNiece and Briddeli, In: Culture of Hematopoietic Cells. Freshney, et al. (eds.) Vol pp. 23-39, Wiley-Liss, Inc., New York, N.Y. 1994; Neben et al., Exp Hematol 22:353-359, 1994; Ploemacher, In: Culture of Hematopoietic Cells. Freshney, et al. eds. Vol pp. 1-21, Wiley-Liss, Inc., New York, N.Y. 1994; Spoonceret al., In: Culture of Hematopoietic Cells. Freshhey, et al., (eds.) Vol pp. 163-179, Wiley-Liss, Inc., New York, N.Y. 1994; Sutherland, In: Culture of Hematopoietic Cells. Freshney, et al., (eds.) Vol pp. 139-162, Wiley-Liss, Inc., New York, N.Y. 1994.

[0302] Tissue Growth Activity

[0303] A GENX protein of the present invention also may have utility in compositions used for bone, cartilage, tendon, ligament and/or nerve tissue growth or regeneration, as well as for wound healing and tissue repair and replacement, and in the treatment of burns, incisions and ulcers.

[0304] A protein of the present invention, which induces cartilage and/or bone growth in circumstances where bone is not normally formed, has application in the healing of bone fractures and cartilage damage or defects in humans and other animals. Such a preparation employing a protein of the invention may have prophylactic use in closed as well as open fracture reduction and also in the improved fixation of artificial joints. De novo bone formation induced by an osteogenic agent contributes to the repair of congenital, trauma induced, or oncologic resection induced craniofacial defects, and also is useful in cosmetic plastic surgery.

[0305] A protein of this invention may also be used in the treatment of periodontal disease, and in other tooth repair processes. Such agents may provide an environment to attract bone-forming cells, stimulate growth of bone-forming cells or induce differentiation of progenitors of bone-forming cells. A protein of the invention may also be useful in the treatment of osteoporosis or osteoarthritis, such as through stimulation of bone and/or cartilage repair or by blocking inflammation or processes of tissue destruction (collagenase activity, osteoclast activity, etc.) mediated by inflammatory processes.

[0306] Another category of tissue regeneration activity that may be attributable to the protein of the present invention is tendon/ligament formation. A protein of the present invention, which induces tendon/ligament-like tissue or other tissue formation in circumstances where such tissue is not normally formed, has application in the healing of tendon or ligament tears, deformities and other tendon or ligament defects in humans and other animals. Such a preparation employing a tendon/ligament-like tissue inducing protein may have prophylactic use in preventing damage to tendon or ligament tissue, as well as use in the improved fixation of tendon or ligament to bone or other tissues, and in repairing defects to tendon or ligament tissue. De novo tendon/ligament-like tissue formation induced by a composition of the present invention contributes to the repair of congenital, trauma induced, or other tendon or ligament defects of other origin, and is also useful in cosmetic plastic surgery for attachment or repair of tendons or ligaments. The compositions of the present invention may provide an environment to attract tendon- or ligament-forming cells, stimulate growth of tendon- or ligament-forming cells, induce differentiation of progenitors of tendon- or ligament-forming cells, or induce growth of tendon/ligament cells or progenitors ex vivo for return in vivo to effect tissue repair. The compositions of the invention may also be useful in the treatment of tendonitis, carpal tunnel syndrome and other tendon or ligament defects. The compositions may also include an appropriate matrix and/or sequestering agent as a career as is well known in the art.

[0307] The protein of the present invention may also be useful for proliferation of neural cells and for regeneration of nerve and brain tissue, i.e. for the treatment of central and peripheral nervous system diseases and neuropathies, as well as mechanical and traumatic disorders, which involve degeneration, death or trauma to neural cells or nerve tissue. More specifically, a protein may be used in the treatment of diseases of the peripheral nervous system, such as peripheral nerve injuries, peripheral neuropathy and localized neuropathies, and central nervous system diseases, such as Alzheimer's, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Shy-Drager syndrome. Further conditions which may be treated in accordance with the present invention include mechanical and traumatic disorders, such as spinal cord disorders, head trauma and cerebrovascular diseases such as stroke. Peripheral neuropathies resulting from chemotherapy or other medical therapies may also be treatable using a protein of the invention.

[0308] Proteins of the invention may also be useful to promote better or faster closure of non-healing wounds, including without limitation pressure ulcers, ulcers associated with vascular insufficiency, surgical and traumatic wounds, and the like.

[0309] It is expected that a protein of the present invention may also exhibit activity for generation or regeneration of other tissues, such as organs (including, for example, pancreas, liver, intestine, kidney, skin, endothelium), muscle (smooth, skeletal or cardiac) and vascular (including vascular endothelium) tissue, or for promoting the growth of cells comprising such tissues. Part of the desired effects may be by inhibition or modulation of fibrotic scarring to allow normal tissue to regenerate. A protein of the invention may also exhibit angiogenic activity.

[0310] A protein of the present invention may also be useful for gut protection or regeneration and treatment of lung or liver fibrosis, reperfusion injury in various tissues, and conditions resulting from systemic cytokine damage.

[0311] A protein of the present invention may also be useful for promoting or inhibiting differentiation of tissues described above from precursor tissues or cells; or for inhibiting the growth of tissues described above.

[0312] The activity of a protein of the invention may, among other means, be measured by the following methods:

[0313] Assays for tissue generation activity include, without limitation, those described in: International Patent Publication No. WO95/16035 (bone, cartilage, tendon); International Patent Publication No. WO95/05846 (nerve, neuronal); International Patent Publication No. WO91/07491 (skin, endothelium).

[0314] Assays for wound healing activity include, without limitation, those described in: Winter, Epidermal Wound Healing, pp. 71-112 (Maibach and Rovee, eds.), Year Book Medical Publishers, Inc., Chicago, as modified by Eaglstein and Menz, J Invest. Dermatol 71:382-84 (1978).

[0315] Activin/Inhibin Activity

[0316] A GENX protein of the present invention may also exhibit activin- or inhibin-related activities. Inhibins are characterized by their ability to inhibit the release of follicle stimulating hormone (FSH), while activins and are characterized by their ability to stimulate the release of follicle stimulating hormone (FSH). Thus, a protein of the present invention, alone or in heterodimers with a member of the inhibin a family, may be useful as a contraceptive based on the ability of inhibins to decrease fertility in female mammals and decrease spermatogenesis in male mammals. Administration of sufficient amounts of other inhibins can induce infertility in these mammals. Alternatively, the protein of the invention, as a homodimer or as a heterodimer with other protein subunits of the inhibin-b group, may be useful as a fertility inducing therapeutic, based upon the ability of activin molecules in stimulating FSH release from cells of the anterior pituitary. See, for example, U.S. Pat. No. 4,798,885. A protein of the invention may also be useful for advancement of the onset of fertility in sexually immature mammals, so as to increase the lifetime reproductive performance of domestic animals such as cows, sheep and pigs.

[0317] The activity of a protein of the invention may, among other means, be measured by the following methods:

[0318] Assays for activin/inhibin activity include, without limitation, those described in: Vale et al., Endocrinology 91:562-572, 1972; Ling et al., Nature 321:779-782, 1986; Vale et al., Nature 321:776-779, 1986; Mason et al., Nature 318:659-663, 1985; Forage et al., Proc Natl Acad Sci USA 83:3091-3095, 1986.

[0319] Chemotactic/Chemokinetic Activity

[0320] A protein of the present invention may have chemotactic or chemokinetic activity (e.g., act as a chemokine) for mammalian cells, including, for example, monocytes, fibroblasts, neutrophils, T-cells, mast cells, eosinophils, epithelial and/or endothelial cells. Chemotactic and chemokinetic proteins can be used to mobilize or attract a desired cell population to a desired site of action. Chemotactic or chemokinetic proteins provide particular advantages in treatment of wounds and other trauma to tissues, as well as in treatment of localized infections. For example, attraction of lymphocytes, monocytes or neutrophils to tumors or sites of infection may result in improved immune responses against the tumor or infecting agent.

[0321] A protein or peptide has chemotactic activity for a particular cell population if it can stimulate, directly or indirectly, the directed orientation or movement of such cell population. Preferably, the protein or peptide has the ability to directly stimulate directed movement of cells. Whether a particular protein has chemotactic activity for a population of cells can be readily determined by employing such protein or peptide in any known assay for cell chemotaxis.

[0322] The activity of a protein of the invention may, among other means, be measured by following methods:

[0323] Assays for chemotactic activity (which will identify proteins that induce or prevent chemotaxis) consist of assays that measure the ability of a protein to induce the migration of cells across a membrane as well as the ability of a protein to induce the adhesion of one cell population to another cell population. Suitable assays for movement and adhesion include, without limitation, those described in: Current Protocols in Immunology, Coligan et al., eds. (Chapter 6.12, Measurement of Alpha and Beta Chemokines 6.12.1-6.12.28); Taub et al. J Clin Invest 95:1370-1376, 1995; Lind et al. APMIS 103:140-146, 1995; Muller et al., Eur J Immunol 25: 1744-1748; Gruberet al. J Immunol 152:5860-5867, 1994; Johnston et al., J Immunol 153: 1762-1768, 1994.

[0324] Hemostatic and Thrombolytic Activity

[0325] A protein of the invention may also exhibit hemostatic or thrombolytic activity. As a result, such a protein is expected to be useful in treatment of various coagulation disorders (including hereditary disorders, such as hemophilias) or to enhance coagulation and other hemostatic events in treating wounds resulting from trauma, surgery or other causes. A protein of the invention may also be useful for dissolving or inhibiting formation of thromboses and for treatment and prevention of conditions resulting therefrom (such as, for example, infarction of cardiac and central nervous system vessels (e.g., stroke).

[0326] The activity of a protein of the invention may,: among other means, be measured by the following methods:

[0327] Assay for hemostatic and thrombolytic activity include, without limitation, those described in: Linet et al., J Clin. Pharmacol. 26:131-140, 1986; Burdick et al., Thrombosis Res. 45:413-419, 1987; Humphrey et al., Fibrinolysis 5:71-79 (1991); Schaub, Prostaglandins 35:467-474, 1988.

[0328] Receptor/Ligand Activity

[0329] A protein of the present invention may also demonstrate activity as receptors, receptor ligands or inhibitors or agonists of receptor/ligand interactions. Examples of such receptors and ligands include, without limitation, cytokine receptors and their ligands, receptor kinases and their ligands, receptor phosphatases and their ligands, receptors involved in cell-cell interactions and their ligands (including without limitation, cellular adhesion molecules (such as selectins, integrins and their ligands) and receptor/ligand pairs involved in antigen presentation, antigen recognition and development of cellular and humoral immune responses). Receptors and ligands are also useful for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. A protein of the present invention (including, without limitation, fragments of receptors and ligands) may themselves be useful as inhibitors of receptor/ligand interactions.

[0330] The activity of a protein of the invention may, among other means, be measured by the following methods:

[0331] Suitable assays for receptor-ligand activity include without limitation those described in: Current Protocols in Immunology, Ed by Coligan, et al., Greene Publishing Associates and Wiley-Interscience (Chapter 7.28, Measurement of Cellular Adhesion under static conditions 7.28.1-7.28.22), Takai et al., Proc Natl Acad Sci USA 84:6864-6868, 1987; Bierer et al., J. Exp. Med. 168:1145-1156, 1988; Rosenstein et al., J Exp. Med. 169:149-160 1989; Stoltenborg et al., J Immunol Methods 175:59-68, 1994; Stitt et al., Cell 80:661-670, 1995.

[0332] Anti-Inflammatory Activity

[0333] Proteins of the present invention may also exhibit anti-inflammatory activity. The anti-inflammatory activity may be achieved by providing a stimulus to cells involved in the inflammatory response, by inhibiting or promoting cell-cell interactions (such as, for example, cell adhesion), by inhibiting or promoting chemotaxis of cells involved in the inflammatory process, inhibiting or promoting cell extravasation, or by stimulating or suppressing production of other factors which more directly inhibit or promote an inflammatory response. Proteins exhibiting such activities can be used to treat inflammatory conditions including chronic or acute conditions), including without limitation inflammation associated with infection (such as septic shock, sepsis or systemic inflammatory response syndrome (SIRS)), ischemia-reperfusion injury, endotoxin lethality, arthritis, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine-induced lung injury, inflammatory bowel disease, Crohn's disease or resulting from over production of cytokines such as TNF or IL-1. Proteins of the invention may also be useful to treat anaphylaxis and hypersensitivity to an antigenic substance or material.

[0334] Tumor Inhibition Activity

[0335] In addition to the activities described above for immunological treatment or prevention of tumors, a protein of the invention may exhibit other anti-tumor activities. A protein may inhibit tumor growth directly or indirectly (such as, for example, via ADCC). A protein may exhibit its tumor inhibitory activity by acting on tumor tissue or tumor precursor tissue, by inhibiting formation of tissues necessary to support tumor growth (such as, for example, by inhibiting angiogenesis), by causing production of other factors, agents or cell types which inhibit tumor growth, or by suppressing, eliminating or inhibiting factors,.agents or cell types which promote tumor growth.

[0336] Other Activities

[0337] A protein of the invention may also exhibit one or more of the following additional activities or effects: inhibiting the growth, infection or function of, or killing, infectious agents, including, without limitation, bacteria, viruses, fingi and other parasites; effecting (suppressing or enhancing) bodily characteristics, including, without limitation, height, weight, hair color, eye color, skin, fat to lean ratio or other tissue pigmentation, or organ or body part size or shape (such as, for example, breast augmentation or diminution, change in bone form or shape); effecting biorhythms or circadian cycles or rhythms; effecting the fertility of male or female subjects; effecting the metabolism, catabolism, anabolism, processing, utilization, storage or elimination of dietary fat, lipid, protein, carbohydrate, vitamins, minerals, cofactors or other nutritional factors or component(s); effecting behavioral characteristics, including, without limitation, appetite, libido, stress, cognition (including cognitive disorders), depression (including depressive disorders) and violent behaviors; providing analgesic effects or other pain reducing effects; promoting differentiation and growth of embryonic stem cells in lineages other than hematopoietic lineages; hormonal or endocrine activity; in the case of enzymes, correcting deficiencies of the enzyme and treating deficiency-related diseases; treatment of hyperproliferative disorders (such as, for example, psoriasis); immunoglobulin-like activity (such as, for example, the ability to bind antigens or complement); and the ability to act as an antigen in a vaccine composition to raise an immune response against such protein or another material or entity which is cross-reactive with such protein.

[0338] Neural disorders in general include Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), peripheral neuropathy, tumors of the nervous system, exposure to neurotoxins, acute brain injury, peripheral nerve trauma or injury, and other neuropathies, epilepsy, and/or tremors.

EQUIVALENTS

[0339] From the foregoing detailed description of the specific embodiments of the invention, it should be apparent that particular novel compositions and methods involving nucleic acids, polypeptides, antibodies, detection and treatment have been described. Although these particular embodiments have been disclosed herein in detail, this has been done by way of example for purposes of illustration only, and is not intended to be limiting with respect to the scope of the appended claims that follow. In particular, it is contemplated by the inventors that various substitutions, alterations, and modifications may be made as a matter of routine for a person of ordinary skill in the art to the invention without departing from the spirit and scope of the invention as defined by the claims. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description and accompanying figures. Such modifications are intended to fall within the scope of the appended claims.

TABLE 1
Entry	Sequence Id	Protein Similarity	Protein Domain	Protein Classification	Tissue Expression
1	13089485 (1957, 1958)	Novel Protein sim. GBank gi|113764|sp|P25718|AMY1_ECOLI-ALPHA-		amylase	1020
		AMYLASE PRECURSOR (1,4-ALPHA-D-GLUCAN
		GLUCANOHYDROLASE)
2	9862020 (493, 494)	Novel Protein sim. GBank gi|2127400|pir||S65770 - maltooligosyltrehalose		amylase	1006
		trehalohydrolase - Arthrobacter sp. (strain Q36)
3	78963176 (609, 610)	Novel Protein sim. GBank gi|4580331|emb|CAB40107.1| - (AJ001206)		amylase	1024, 1038
		putative glycogen debranching enzyme [Streptomyces coellcolor]
4	19646712 (803, 804)	Novel Protein sim. GBank gi|728851|sp|Q05884|AMY_STRLI - ALPHA-		amylase	1008
		AMYLASE PRECURSOR (1,4-ALPHA-D-GLUCAN
		GLUCANOHYDROLASE)
5	80218543 (5115, 5116)	Novel Protein sim. GBank gi|266398|sp|P01088|ITRF_MAIZE -		amylaseinhib	1002, 1003, 1006, 1007,
		TRYPSIN/FACTOR XIIA INHIBITOR PRECURSOR (HAGEMAN FACTOR			1020, 1022, 1024, 1031
		INHIBITOR) (CHFI)
6	36996488 (6391, 6392)	Novel Protein sim. GBank gi|4757752|ref|NP_004664.1|pANGP -	Contains protein domain	angiopoietin	1001, 1003
		angiopoietin 3	(PF00147) - Fibrinogen beta and
			gamma chains, C-terminal
			globular domain
7	19507966 (3275, 3276)	Novel Protein sim. GBank gi|135809|sp|P18292|THRB_RAT -	Contains protein domain	apolipoprotein	1022
		PROTHROMBIN PRECURSOR	(PF00051) - Kringle domain
8	78748816 (1433, 1434)	Novel Protein sim. GBank gi|91984|pir||A24700 - apolipoprotein A-I		apolipoprotein	1041
		precursor - rat
9	65864934 (509, 510)	Novel Protein sim. GBank gi|1449179|dbj|BAA13101| - (D86506) N-	Contains protein domain	ATPase_associated	1014
		ethylmaleimide sensitive fusion protein [Nicotiana tabacum]	(PF00004) - ATPases associated
			with various cellular activities
			(AAA)
10	16835471 (1903, 1904)	Novel Protein sim. GBank gi|295644 (J04421) - ATPase [Saccharomyces	Contains protein domain	ATPase_associated	1015
		cerevislae]	(PF00122) - E1-E2 ATPase
11	78669846 (6615, 6616)	Novel Protein sim. GBank gi|295644 (J04421) - ATPase [Saccharomyces	Contains protein domain	ATPase_associated	1007
		cerevislae]	(PF00122) - E1-E2 ATPase
12	78696296 (219, 220)	Novel Protein sim. GBank gi|417496|sp|P33158|PMGY_STRCO -	Contains protein domain	ATPase_associated	1015
		PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	(PF00300) - Phosphoglycerate
		(PGAM) (BPG-DEPENDENT PGAM)	mutase family
13	78895589 (5555, 5556)	Novel Protein sim. GBank gi|549614|sp|P36137|YK24_YEAST -	Contains protein domain	ATPase_associated	1015, 1036
		HYPOTHETICAL 51.0 KD PROTEIN IN GAP1-NAP1 INTERGENIC	(PF00300) - Phosphoglycerate
		REGION	mutase family
14	57303171 (5323, 5324)	Novel Protein sim. GBank gi|1854476|dbj|BAA07458.1| - (D38380)	Contains protein domain	ATPase_associated	1003, 1004, 1006, 1007,
		transferrin [Rattus norvegicus]	(PF00405) - Transferrin		1020, 1024
15	80248523 (3455, 3456)	Novel Protein sim. GBank gi|2326751|emb|CAB10965| - (Z98268)	Contains protein domain	ATPase_associated	1002, 1004, 1008, 1020,
		hypothetical protein Rv1708 [Mycobacterium tuberculosis]	(PF00991) - ParA family ATPase		1022, 1028, 1031, 1036
16	29202483 (2287, 2288)	Novel Protein sim. GBank gi|124205|sp|P09064|IF2B_YEAST -		ATPase_associated	1004, 1020, 1021, 1022,
		EUKARYOTIC TRANSLATION INITIATION FACTOR 2 BETA SUBUNIT			1031
		EIF-2-BETA
17	80237817 (1631, 1632)	Novel Protein sim. GBank gi|171544 (M34709) - pot. ORF; putative		ATPase_associated	1004, 1006, 1022, 1035
		[Saccharomyces cerevisiae]
18	79874660 (4591, 4592)	Novel Protein sim. GBank gi|1730836|sp|P23503|YNY0_YEAST -		ATPase_associated	1001
		HYPOTHETICAL 54.2 KD PROTEIN IN ZWF1-BLH1/LAP3 INTERGENIC
		REGION
19	79829954 (1169, 1170)	Novel Protein sim. GBank gi|2131333|pir||S67642 - hypothetical protein		ATPase_associated	1006, 1007, 1015, 1036
		YDL100c - yeast (Saccharomyces cerevisiae)
20	27838931 (7009, 7010)	Novel Protein sim. GBank gi|2132688|pir||S64942 - probable membrane		ATPase_associated	1002, 1004, 1020, 1022,
		protein YLR106c - yeast (Saccharomyces cerevisiae)			1031
21	23308866 (1159, 1160)	Novel Protein sim. GBank gi|2654870 (AF015302) - RbohAOsp [Oryza		ATPase_associated	1050
		sativa]
22	71229404 (5033, 5034)	Novel Protein sim. GBank gi|2668599 (AF012537) - ATPase		ATPase_associated	1000
		[Pseudomonas aeruginosa]
23	80496778 (7757, 7758)	Novel Protein sim. GBank gi|2895095 (AF011337) - putative E1-E2		ATPase_associated	1002, 1006, 1008, 1010,
		ATPase [Mus musculus]			1041
24	20290015 (2341, 2342)	Novel Protein sim. GBank gi|4585584|emb|CAB40852.1| - (AL049628)		ATPase_associated	1031
		putative DNA-binding protein [Streptomyces coelicolor]
25	9945091 (4139, 4140)	Novel Protein sim. GBank gi|461975|sp|P34036|DYHC_DICDI - DYNEIN		ATPase_associated	1015
		HEAVY CHAIN, CYTOSOLIC (DYHC)
26	17940495 (4187, 4188)	Novel Protein sim. GBank gi|465495|sp|P33595|YABN_ECOLI -		ATPase_associated	1036
		HYPOTHETICAL 63.9 KD PROTEIN IN TBPA-LEUD INTERGENIC
		REGION (ORF103)
27	56285913 (1495, 1496)	Novel Protein sim. GBank gi|4982470|gb|AAD31036.2|AF14193 -		ATPase_associated	1002
		(AF141934) sodium bicarbonate cotransporter NBC1 [Mus musculus]
28	78963164 (8137, 8138)	Novel Protein sim. GBank gi|4982470|gb|AAD31036.2|AF14193 -		ATPase_associated	1022, 1027
		(AF141934) sodium bicarbonate cotransporter NBC1 [Mus musculus]
29	95105757 (7549, 7550)	Novel Protein sim. GBank gi|5174779|gb|AAD40696.1| - (U87804) 50 kDa		ATPase_associated	1008
		protein [Caulobacter crescentus]
30	50098031 (7163, 7164)	Novel Protein sim. GBank gi|687204 (U03973) - dynein heavy chain		ATPase_associated	1033
		isotype 4 [Tripneustes gratilla]
31	80053071 (8477, 8478)	Novel Protein sim. GBank gi|807957|emb|CAA89222| - (Z49259) unknown		ATPase_associated	1001, 1003, 1007, 1015,
		[Saccharomyces cerevisiae]			1023, 1028, 1035
32	85813960 (6501, 6502)	Novel Protein sim. GBank gi|118353|sp|P13187|DCOA_KLEPN -		biotindep	1051
		OXALOACETATE DECARBOXYLASE ALPHA CHAIN
33	95104899 (3489, 3490)	Novel Protein sim. GBank gi|1345960|sp|P33450|FAT_DROME -	Contains protein domain	cadherin	1004, 1007, 1008, 1046
		CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT	(PF00028) - Cadherin domain
		PROTEIN)
34	34405797 (565, 566)	Novel Protein sim. GBank gi|2764994|emb|CAA69965| - (Y08715)	Contains protein domain	cadherin	1051
		vascular cadherin-2 [Mus musculus]	(PF00028) - Cadherin domain
35	87898594 (6959, 6960)	Novel Protein sim. GBank gi|1825710 (U88183) - ZK377.2 gene product	Contains protein domain	cadherin	1013
		[Caenorhabditis elegans]	(PF00047) - Immunoglobulin
			domain
36	80032194 (8345, 8346)	Novel Protein sim. GBank gi|1345960|sp|P33450|FAT_DROME -		cadherin	1050
		CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT
		PROTEIN)
37	23209902 (3369, 3370)	Novel Protein sim. GBank gi|2137142|pir||I61186 - alpha-7 integrin -		cadherin	1002
		mouse
38	8367741 (1853, 1854)	Novel Protein sim. GBank gi|3095102 (AF043257) - beta5B integrin [Mus		cadherin	1008
		musculus]
39	79811289 (1929, 1930)	Novel Protein sim. GBank gi|3122261|sp|Q12522|IF6_YEAST -		cadherin	1006
		EUKARYOTIC TRANSLATION INITIATION FACTOR 6 (EIF-6)
40	78780522 (4215, 4216)	Novel Protein sim. GBank gi|423613|pir||A46052 - vascular cell adhesion		cadherin	1020
		molecule 1, GPI-anchored splice form - mouse
41	78902729 (2379, 2380)	Novel Protein sim. GBank gi|466085|sp|P34616|YOG7_CAEEL -		cadherin	1006
		HYPOTHETICAL 375.7 KD PROTEIN ZK112.7 PRECURSOR IN
		CHROMOSOME III
42	29226009 (3259, 3260)	Novel Protein sim. GBank gi|5456975|gb|AAD43730.1| - (AF152336)		cadherin	1051
		protocadherin gamma B7 [Homo sapiens]
43	11090708 (8653, 8654)	Novel Protein sim. GBank gi|902358|emb|CAA61165| - (X87941) ORF		calcium_channel	1004
		857 [Saccharomyces cerevisiae]
44	56945240 (1213, 1214)	Novel Protein sim. GBank gi|515236|pdb|1PYD|A - Saccharomyces	Contains protein domain	carboxylase	1002, 1022, 1036
		bayanus	(PF00205) - Thiamine
			pyrophosphate enzymes
45	78916253 (7447, 7448)	Novel Protein sim. GBank gi|585765|sp|P32327|PYC2_YEAST -	Contains protein domain	carboxylase	1006, 1036
		PYRUVATE CARBOXYLASE 2 (PYRUVIC CARBOXYLASE 2) (PCB 2)	(PF00289) - Carbamoyl-
			phosphate synthase (CPSase)
46	79829360 (1891, 1892)	Novel Protein sim. GBank gi|2145998|pir||S73055 - pyc protein -	Contains protein domain	carboxylase	1041
		Mycobacterium tuberculosis	(PF00364) - Biotin-requiring
			enzymes
47	80503126 (6595, 6596)	Novel Protein sim. GBank gi|1850108|emb|CAB06690| - (Z86089)		carboxylase	1004, 1006, 1008, 1010,
		hypothetical protein Rv0263c [Mycobacterium tuberculosis]			1015, 1021, 1022, 1025,
					1028, 1035
48	20725040 (8787, 8788)	Novel Protein sim. GBank gi|2506124|sp|P08193|ACCD_ECOLI -		carboxylase	1022
		ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE
		SUBUNIT BETA
49	19881269 (2869, 2870)	Novel Protein sim. GBank gi|2749948 (U94697) - propionyl-CoA		carboxylase	1031
		carboxylase beta chain homolog [Caulobacter crescentus]
50	37035436 (7151, 7152)	Novel Protein sim. GBank gi|5019761|gb|AAD37851.1|AF12642 -		carboxylase	1010
		(AF126429) JadJ [Streptomyces venezuelae]
51	8491135 (8343, 8344)	Novel Protein sim. GBank gi|137120|sp|P11214|UROT_MOUSE -	Contains protein domain	cathepsin	1031
		TISSUE PLASMINOGEN ACTIVATOR PRECURSOR (TPA) (T-	(PF00051) - Kringle domain
		PLASMINOGEN ACTIVATOR)
52	78478107 (1485, 1486)	Novel Protein sim. GBank gi|4210355|emb|CAA18442| - (AL022314)	Contains protein domain	cathepsin	1002
		dJ1170K4.2 (novel Trypsin family protein with class A LDL receptor	(PF00089) - Trypsin
		domains) [Homo sapiens]
53	57302877 (5459, 5460)	Novel Protein sim. GBank gi|4506153|ref|NP_002764.1|pPRSS -	Contains protein domain	cathepsin	1004, 1007, 1024, 1041
		protease, serine, 8 (prostasin)	(PF00089) - Trypsin
54	80239316 (6353, 6354)	Novel Protein sim. GBank gi|134734|sp|P05044|SORC_CRILO - SORCIN		cathepsin	1004, 1031
		(22 KD PROTEIN) (CP-22) (V19)
55	78753812 (4167, 4168)	Novel Protein sim. GBank gi|1708879|sp|P51885|LUM_MOUSE -	Contains protein domain	collagen	1002
		LUMICAN PRECURSOR (LUM) (KERATAN SULFATE	(PF00560) - Leucine Rich Repeat
		PROTEOGLYCAN)
56	77651711 (1825, 1826)	Novel Protein sim. GBank gi|1705570|sp|P51942|CAMA_MOUSE -		collagen	1035
		CARTILAGE MATRIX PROTEIN PRECURSOR (MATRILIN-1)
57	90936827 (1257, 1258)	Novel Protein sim. GBank gi|387115 (M15832) - type IV collagen alpha-1		collagen	1018
		[Mus musculus]
58	95419866 (2131, 2132)	Novel Protein sim. GBank gi|4539386|emb|CAB37452.1| - (AL035526)		collagen	1006, 1015, 1021, 1035,
		extensin-like protein [Arabidopsis thaliana]			1036, 1041, 1051
59	86380200 (5865, 5866)	Novel Protein sim. GBank gi|4704417|gb|AAD28083.1| - (AF056183) WS		collagen	1050
		beta-transducin repeats protein [Homo sapiens]
60	20756502 (199, 200)	Novel Protein sim. GBank gi|765323|bbs|157676 - (S74439) silk fibroin		collagen	1020
		heavy chain (C-terminal) [Bombyx mori = silkworms, Peptide Partial, 633
		aa] [Bombyx mori]
61	10297625 (1933, 1934)			collagen	1023
62	95314273 (3611, 3612)			collagen	1006, 1026, 1031, 1041
63	81953722 (8775, 8776)	Novel Protein sim. GBank gi|204657 (K01933) - preprohaptoglobin	Contains protein domain	complement	1007, 1008, 1014, 1020,
		[Rattus norvegicus]	(PF00089) - Trypsin		1024, 1036
64	78835967 (3681, 3682)	Novel Protein sim. GBank gi|116597|sp|P01026|CO3_RAT -	Contains protein domain	complement	1007
		COMPLEMENT C3 PRECURSOR (CONTAINS: C3A ANAPHYLATOXIN)	(PF00207) - Alpha-2-
			macroglobulin family
65	90936839 (3791, 3792)	Novel Protein sim. GBank gi|116597|sp|P01026|CO3_RAT -	Contains protein domain	complement	1004, 1008, 1015, 1018,
		COMPLEMENT C3 PRECURSOR (CONTAINS: C3A ANAPHYLATOXIN)	(PF00207) - Alpha-2-		1020, 1024
			macroglobulin family
66	8522842 (1871, 1872)	Novel Protein sim. GBank gi|116608|sp|P06684|CO5_MOUSE -	Contains protein domain	complement	1031
		COMPLEMENT C5 PRECURSOR (CONTAINS: C5A ANAPHYLATOXIN)	(PF00207) - Alpha-2-
			macroglobulin family
67	8522050 (5503, 5504)	Novel Protein sim. GBank gi|112893|sp|P14046|A1I3_RAT - ALPHA-1-	Contains protein domain	complement	1003
		INHIBITOR III PRECURSOR	(PF01835) - Alpha-2-
			macroglobulin family N-terminal
			region
68	52563488 (3181, 3182)	Novel Protein sim. GBank gi|129701|sp|P15873|PCNA_YEAST -		cyclin	1002
		PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA)
69	20738462 (1821, 1822)	Novel Protein sim. GBank gi|1345736|sp|P20437|CG11_YEAST - G1/S-		cyclin	1031
		SPECIFIC CYCLIN CLN1
70	94143356 (5979, 5980)	Novel Protein sim. GBank gi|117245|sp|P12939|CPD5_RAT -	Contains protein domain	cyto450	1008, 1031
		CYTOCHROME P450 2D5 (CYPIID5) (P450-DB5) (P450-CMF1B)	(PF00067) - Cytochrome P450
		(DEBRISOQUINE 4-HYDROXYLASE)
71	29459361 (317, 318)	Novel Protein sim. GBank gi|117254|sp|P24461 |CPG1_RABIT -	Contains protein domain	cyto450	1020
		CYTOCHROME P450 2G1 (CYPIIG1) (P450-NMB) (OLFACTIVE)	(PF00067) - Cytochrome P450
72	16835554 (2401, 2402)	Novel Protein sim. GBank gi|1706098|sp|P51590|CPJ3_RAT -	Contains protein domain	cyto450	1015
		CYTOCHROME P450 2J3 (CYPIIJ3)	(PF00067) - Cytochrome P450
73	71228838 (7637, 7638)	Novel Protein sim. GBank gi|2117409|pir||I49625 - testosterone 16a-	Contains protein domain	cyto450	1006, 1014, 1020
		hydroxylase type b - mouse	(PF00067) - Cytochrome P450
74	29246103 (1343, 1344)	Novel Protein sim. GBank gi|2760837|gb|AAB95305.1| - (AC003105)	Contains protein domain	cyto450	1007
		putative cytochrome P450 [Arabidopsis thaliana]	(PF00067) - Cytochrome P450
75	65460027 (6215, 6216)	Novel Protein sim. GBank gi|320081|pir||A34272 - testosterone 7 alpha-	Contains protein domain	cyto450	1051
		hydroxylase (EC 1.14.14.—) cytochrome P450 2A1 - rat	(PF00067) - Cytochrome P450
76	25170872 (2171, 2172)	Novel Protein sim. GBank gi|498858 (U09734) - testosterone 6-beta-	Contains protein domain	cyto450	1003, 1007
		hydroxylase [Rattus norvegicus]	(PF00067) - Cytochrome P450
77	8489815 (7075, 7076)	Novel Protein sim. GBank gi|1421741 (U54770) - cytochrome P450		cyto450	1031
		homolog [Lycopersicon esculentum]
78	38927279 (1693, 1694)	Novel Protein sim. GBank gi|4587057|dbj|BAA76602.1| - (AB018596)		cyto450	1006
		sterol 12-alpha hydroxylase [Rattus norvegicus]
96	78516862 (4847, 4848)	Novel Protein sim. GBank gi|729306|sp|P06773|DCTD_YEAST -		deaminase	1007
		DEOXYCYTIDYLATE DEAMINASE (DCMP DEAMINASE)
97	9367144 (3133, 3134)	Novel Protein sim. GBank gi|2497263|sp|Q51375|LEU3_PSEAE - 3-	Contains protein domain	dehydrogenase	1015
		ISOPROPYLMALATE DEHYDROGENASE (BETA-IPM	(PF00180) - Isocitrate and
		DEHYDROGENASE) (IMDH) (3-IPM-DH)	isopropylmalate dehydrogenases
98	85530525 (7209, 7210)	Novel Protein sim. GBank gi|3790552 (AF069035) - isocitrate	Contains protein domain	dehydrogenase	1035
		dehydrogenase [Coxiella bumetii]	(PF00180) - Isocitrate and
			isopropylmalate dehydrogenases
99	66396086 (4085, 4086)	Novel Protein sim. GBank gi|4033783|sp|P42958|YCSA_BACSU -	Contains protein domain	dehydrogenase	1006
		HYPOTHETICAL 33.1 KD PROTEIN IN MTLD-SIPU INTERGENIC	(PF00180) - Isocitrate and
		REGION	isopropylmalate dehydrogenases
100	13022417 (2971, 2972)	Novel Protein sim. GBank gi|1477946|bbs|177171 - (S81735) leucine	Contains protein domain	dehydrogenase	1022
		dehydrogenase (EC 1.4.1.9) [Bacillus licheniformls, TSN9, Peptide, 364	(PF00208) -
		aa] [Bacillus licheniformis]	Glutamate/Leucine/Phenylalanine/
			Valine dehydrogenase
101	80249569 (1309, 1310)	Novel Protein sim. GBank gi|322228|pir||S32227 - glutamate	Contains protein domain	dehydrogenase	1004, 1051
		dehydrogenase (NADP+) (EC 1.4.1.4) - Corynebacterium glutamicum	(PF00208) -
			Glutamate/Leucine/Phenylalanine/
			Valine dehydrogenase
102	25261707 (2575, 2576)	Novel Protein sim. GBank gi|3947740|emb|CAA77186| - (Y18476) NADH	Contains protein domain	dehydrogenase	1006
		dehydrogenase subunit 2 [Trichophyton rubrum]	(PF00361) - NADH-
			Ubiquinone/plastoquinone
			(complex I), various chains
103	80083230 (2743, 2744)	Novel Protein sim. GBank gi|1352619|sp|P19262|ODO2_YEAST -	Contains protein domain	dehydrogenase	1001, 1006, 1008, 1014,
		DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE COMPONENT OF 2-	(PF00364) - Biotin-requiring		1015, 1022, 1041
		OXOGLUTARATE DEHYDROGENASE COMPLEX PRECURSOR (E2)	enzymes
104	82133796 (4013, 4014)	Novel Protein sim. GBank gi|2132191|pir||S62008 - hypothetical protein	Contains protein domain	dehydrogenase	1002, 1003, 1004, 1006,
		YPL113c - yeast (Saccharomyces cerevisiae)	(PF00389) - D-isomer specific 2-		1014, 1020, 1024, 1031,
			hydroxyacid dehydrogenases		1041
105	27983417 (5005, 5006)	Novel Protein sim. GBank gi|2708656 (AF037440) - D-3-	Contains protein domain	dehydrogenase	1006
		phosphoglycerate dehydrogenase [Edwardsiella ictaluri]	(PF00389) - D-isomer specific 2-
			hydroxyacid dehydrogenases
106	80080941 (8083, 8064)	Novel Protein sim. GBank gi|3122346|sp|Q59642|LDHD_PEDAC - D-	Contains protein domain	dehydrogenase	1031
		LACTATE DEHYDROGENASE (D-LDH)	(PF00389) - D-Isomer specific 2-
			hydroxyacid dehydrogenases
107	82442962 (6449, 6450)	Novel Protein sim. GBank gi|3123275|sp|P35136|SERA_BACSU - D-3-	Contains protein domain	dehydrogenase	1001, 1020, 1025, 1031
		PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)	(PF00389) - D-isomer specific 2-
			hydroxyacid dehydrogenases
108	14218605 (5049, 5050)	Novel Protein sim. GBank gi|4155559 (AE001527) - D-3-	Contains protein domain	dehydrogenase	1050
		PHOSPHOGLYCERATE DEHYDROGENASE [Helicobacter pylori J99]	(PF00389) - D-Isomer specific 2-
			hydroxyacid dehydrogenases
109	94745539 (8077, 8078)	Novel Protein sim. GBank gi|205294 (M26594) - malic enzyme [Rattus	Contains protein domain	dehydrogenase	1002
		norvegicus]	(PF00390) - Malic enzyme
110	17673515 (8729, 8730)	Novel Protein sim. GBank gi|3047125 (AF058919) - No definition line	Contains protein domain	dehydrogenase	1006
		found [Arabidopsis thaliana]	(PF00390) - Malic enzyme
111	12997849 (7605, 7606)	Novel Protein sim. GBank gi|581228|emb|CAA39419| - (X55956)	Contains protein domain	dehydrogenase	1025
		altemative [Escherichia coli]	(PF00390) - Malic enzyme
112	47656812 (3459, 3460)	Novel Protein sim. GBank gi|1321895|emb|CAA63250| - (X92503) gnd	Contains protein domain	dehydrogenase	1026
		[Mycobacterium smegmatis]	(PF00393) - 6-phosphogluconate
			dehydrogenases
113	39554838 (5427, 5428)	Novel Protein sim. GBank gi|2117216|emb|CAB09054| - (Z95585) gnd2	Contains protein domain	dehydrogenase	1036
		[Mycobacterium tuberculosis]	(PF00393) - 6-phosphogluconate
			dehydrogenases
114	82443593 (4667, 4668)	Novel Protein sim. GBank gi|2829816|sp|P95171|NUOK_MYCTU - NADH	Contains protein domain	dehydrogenase	1001, 1004, 1010, 1020,
		DEHYDROGENASE I CHAIN K (NADH-UBIQUINONE	(PF00420) - NADH-		1022, 1031
		OXIDOREDUCTASE CHAIN 11) (NUO11)	ubiquinone/plastoquinone
			oxidoreductase chain 4L
115	80419176 (2053, 2054)	Novel Protein sim. GBank gi|1877329|emb|CAB07077| - (Z92771) fadE25	Contains protein domain	dehydrogenase	1002, 1003, 1004, 1008,
		[Mycobacterium tuberculosis]	(PF00441) - Acyl-CoA		1015, 1020, 1022, 1023,
			dehydrogenase		1031, 1050
116	79633434 (8485, 8486)	Novel Protein sim. GBank gi|1073456|pir||S47810 - probable alcohol	Contains protein domain	dehydrogenase	1036
		dehydrogenase (EC 1.1.1.1) - Escherichia coli	(PF00465) - Iron-containing
			alcohol dehydrogenases
117	21427080 (6543, 6544)	Novel Protein sim. GBank gi|1732040 (U55016) - alcohol dehydrogenase	Contains protein domain	dehydrogenase	1020
		[Actinobacillus pleuropneumoniae]	(PF00465) - Iron-containing
			alcohol dehydrogenases
118	80409743 (603, 604)	Novel Protein sim. GBank gi|5459404|emb|CAB50762.1| - (AL096839)	Contains protein domain	dehydrogenase	1001, 1003, 1004, 1014,
		putative glucose-6-phosphate 1-dehydrogenase [Streptomyces coelicolor]	(PF00479) - Glucose-6-phosphate		1020, 1022, 1024, 1026
			dehydrogenase
119	80060092 (6903, 6904)	Novel Protein sim. GBank gi|1708477|sp|P50095|IMH2_YEAST -	Contains protein domain	dehydrogenase	1020, 1041
		PROBABLE INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE (IMP	(PF00571) - CBS domain
		DEHYDROGENASE) (IMPDH) (IMPD)
120	87454335 (4901, 4902)	Novel Protein sim. GBank gi|5104022|dbj|BAA79338.1| - (AP000059)	Contains protein domain	dehydrogenase	1002, 1023, 1055
		147aa long hypothetical protein [Aeropyrum pemix]	(PF00571) - CBS domain
121	79489230 (6997, 6998)	Novel Protein sim. GBank gi|3242279|emb|CAA16667| - (AL021646) nuoL	Contains protein domain	dehydrogenase	1035, 1036
		[Mycobacterium tuberculosis]	(PF00662) - NADH-Ubiquinone
			oxidoreductase (complex I), chain
			5 N-terminus
122	79624876 (785, 786)	Novel Protein sim. GBank gi|231993|sp|Q00711|DHSA_YEAST -	Contains protein domain	dehydrogenase	1004, 1041
		SUCCINATE DEHYDROGENASE (UBIQUINONE) FLAVOPROTEIN	(PF00890) - FAD binding domain
		SUBUNIT PRECURSOR (FP) (FLAVOPROTEIN SUBUNIT OF COMPLEX
		II)
123	20292751 (8493, 8494)	Novel Protein sim. GBank gi|3329036 (AE001330) - Succinate	Contains protein domain	dehydrogenase	1031
		Dehydrogenase [Chlamydia trachomatis]	(PF00890) - FAD binding domain
124	20617170 (7759, 7760)	Novel Protein sim. GBank gi|2506955|sp|P33601|NUOE_ECOLI - NADH	Contains protein domain	dehydrogenase	1003
		DEHYDROGENASE I CHAIN E (NADH-UBIQUINONE	(PF01257) - Respiratory-chain
		OXIDOREDUCTASE CHAIN 5) (NUO5)	NADH dehydrogenase 24 Kd
			subunit
125	20695817 (8371, 8372)	Novel Protein sim. GBank gi|1041092 (L48550) - methylmalonic acid		dehydrogenase	1031
		semialdehyde dehydrogenase [Streptomyces coelicolor]
126	78484712 (515, 516)	Novel Protein sim. GBank gi|1076668|pir||S52261 - NADH dehydrogenase		dehydrogenase	1024
		(EC 1.6.99.3) - potato
127	46850827 (3627, 3628)	Novel Protein sim. GBank gi|1169602|sp|P45382|FADH_PARDE -		dehydrogenase	1026
		GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE
		(FDH) (FALDH) (GD-FALDH)
128	25306971 (3101, 3102)	Novel Protein sim. GBank gi|1170799|sp|P46454|LLDD_HAEIN - L-		dehydrogenase	1020
		LACTATE DEHYDROGENASE (CYTOCHROME)
129	13526472 (2345, 2346)	Novel Protein sim. GBank gi|1172706|sp|P45107|PTA_HAEIN -		dehydrogenase	1025
		PHOSPHATE ACETYLTRANSFERASE (PHOSPHOTRANSACETYLASE)
130	80029007 (5997, 5998)	Novel Protein sim. GBank gi|120777|sp|P25526|GABD_ECOLI -		dehydrogenase	1004, 1017
		SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (NADP+) (SSDH)
131	78805052 (8239, 8240)	Novel Protein sim. GBank gi|1223606|emb|CAA65298| - (X96434) moxR		dehydrogenase	1014
		[Borrelia burgdorferi]
132	5621309 (2895, 2896)	Novel Protein sim. GBank gi|123178|sp|P24226|HISX_BRAOC -		dehydrogenase	1055
		HISTIDINOL DEHYDROGENASE, CHLOROPLAST PRECURSOR (HDH)
133	79398232 (3271, 3272)	Novel Protein sim. GBank gi|1262198 (U39263) - proline dehydrogenase		dehydrogenase	1004
		[Agrobacterium tumefaciens]
134	79580022 (5545, 5546)	Novel Protein sim. GBank gi|128741|sp|P03910|NU4M_BOVIN - NADH-		dehydrogenase	1008
		UBIQUINONE OXIDOREDUCTASE CHAIN 4
135	5496494 (5075, 5076)	Novel Protein sim. GBank gi|1346120|sp|P49095|GCSP_YEAST -		dehydrogenase	1055
		GLYCINE DEHYDROGENASE (DECARBOXYLATING) PRECURSOR
		(GLYCINE DECARBOXYLASE) (GLYCINE CLEAVAGE SYSTEM P-
		PROTEIN)
136	66404023 (6207, 6208)	Novel Protein sim. GBank gi|146177 (M20938) - glycerol-3-phosphate		dehydrogenase	1020
		dehydrogenase subunit A [Escherichia coli]
137	25264259 (2187, 2188)	Novel Protein sim. GBank gi|1652865|dbj|BAA17783| - (D90909) NADH		dehydrogenase	1002
		dehydrogenase [Synechocystis sp.]
138	80249306 (1565, 1566)	Novel Protein sim. GBank gi|1658402 (U73807) - formate dehydrogenase		dehydrogenase	1004, 1020, 1028, 1039
		beta subunit [Moorella thermoacetica]
139	11100223 (3499, 3500)	Novel Protein sim. GBank gi|1706887|sp|P51696|FOLD_PHOPO -		dehydrogenase	1020
		METHYLENETETRAHYDROFOLATE DEHYDROGENASE/
		METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE
140	19881142 (8387, 8388)	Novel Protein sim. GBank gi|1707879|sp|P54261|GCST_SYNY3 -		dehydrogenase	1031
		PROBABLE AMINOMETHYL TRANSFERASE (GLYCINE CLEAVAGE
		SYSTEM T PROTEIN)
141	29463275 (7459, 7460)	Novel Protein sim. GBank gi|1710631|sp|P55006|ROH3_RAT - RETINOL		dehydrogenase	1020
		DEHYDROGENASE TYPE III (RODH III)
142	86475450 (2047, 2048)	Novel Protein sim. GBank gi|1723372|sp|Q01333|YCR4_ERWHE -		dehydrogenase	1045
		HYPOTHETICAL 11.2 KD PROTEIN IN CRTE 3′REGION (ORF4)
143	9524765 (7755, 7756)	Novel Protein sim. GBank gi|1730163|sp|P51009|G3P_XANFL -		dehydrogenase	1031
		GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (GAPDH)
144	87456832 (6409, 6410)	Novel Protein sim. GBank gi|1848283 (U87982) - Sorghum bicolor		dehydrogenase	1023
		aldehyde dehydrogenase (Dha1) mRNA, partial sequence
145	33202157 (3629, 3630)	Novel Protein sim. GBank gi|2108268|emb|CAA63467| - (X92868) NADP-		dehydrogenase	1024
		dependent alcohol dehydrogenase [Bacillus subtilis]
146	11070327 (8561, 8562)	Novel Protein sim. GBank gi|2121110|pir||I69649 - dTDP-6-deoxy-L-		dehydrogenase	1022
		mannose-dehydrogenase - Escherichia coli
147	11355842 (8171, 8172)	Novel Protein sim. GBank gi|2144098|pir||I56573 - SC2 - rat		dehydrogenase	1055
148	79182952 (7731, 7732)	Novel Protein sim. GBank gi|2493994|sp|Q47945|CYCA_GLUSU -		dehydrogenase	1003
		ALCOHOL DEHYDROGENASE CYTOCHROME C SUBUNIT
		PRECURSOR (CYTOCHROME C-553) (C553) (G3-ADH SUBUNIT II)
149	25165320 (5447, 5448)	Novel Protein sim. GBank gi|2498413|sp|Q48485|GLF1_KLEPN -		dehydrogenase	1002
		PROBABLE UDP-GALACTOPYRANOSE MUTASE
150	56307045 (1285, 1286)	Novel Protein sim. GBank gi|2498557|sp|P77580|MHPF_ECOLI -		dehydrogenase	1002, 1015, 1021
		ACETALDEHYDE DEHYDROGENASE (ACETALDEHYDE
		DEHYDROGENASE [ACETYLATING])
151	79603387 (7911, 7912)	Novel Protein sim. GBank gi|2578379|emb|CAA15464| - (AL008609)		dehydrogenase	1031
		glycine dehydrogenase (decarboxylating) [Mycobacterium leprae]
152	80248682 (6327, 6328)	Novel Protein sim. GBank gi|2624302|emb|CAA15575| - (AL008967) aid		dehydrogenase	1004, 1008, 1010, 1028,
		[Mycobacterium tuberculosis]			1031
153	30422405 (2133, 2134)	Novel Protein sim. GBank gi|2661213 (U89280) - oxidative 17 beta		dehydrogenase	1006
		hydroxysteroid dehydrogenase type 6 [Rattus norvegicus]
154	94315307 (4067, 4068)	Novel Protein sim. GBank gi|2695834|emb|CAA15904| - (AL021006) sucA		dehydrogenase	1003, 1007, 1008, 1021,
		[Mycobacterium tuberculosis]			1022, 1031, 1036
155	95289134 (1589, 1590)	Novel Protein sim. GBank gi|2894186|emb|CAA11792.1| - (AJ223999)		dehydrogenase	1003, 1004, 1008, 1022,
		PCZA363.1 [Amycolatopsis orientalis]			1036
156	44985946 (5867, 5868)	Novel Protein sim. GBank gi|2894212|emb|CAA17075.1| - (AL021841)		dehydrogenase	1026
		IpdA [Mycobacterium tuberculosis]
157	80027352 (6859, 6860)	Novel Protein sim. GBank gi|2909538|emb|CAA17417| - (AL021933)		dehydrogenase	1004, 1023, 1031
		hypothetical protein Rv0462 [Mycobacterium tuberculosis]
158	80217428 (6011, 6012)	Novel Protein sim. GBank gi|297922|emb|CAA46852| - (X66052) D-		dehydrogenase	1008, 1010, 1020, 1022,
		lactate dehydrogenase (cytochrome) [Saccharomyces cerevisiae]			1028
159	27362878 (7839, 7840)	Novel Protein sim. GBank gi|297922|emb|CAA46852| - (X66052) D-		dehydrogenase	1020
		lactate dehydrogenase (cytochrome) [Saccharomyces cerevisiae]
160	80306398 (5203, 5204)	Novel Protein sim. GBank gi|2995297|emb|CAA18326| - (AL022268)		dehydrogenase	1000, 1002, 1003, 1004,
		hypothetical protein SC4H2.10c [Streptomyces coelicolor]			1006, 1008, 1010, 1020,
					1023, 1025, 1026, 1031,
					1035, 1036
161	13085569 (3485, 3486)	Novel Protein sim. GBank gi|3121992|sp|P81178|DHAM_MESAU -		dehydrogenase	1025
		ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (CLASS 2) (ALDH1)
		(ALDH-E2)
162	11385242 (4991, 4992)	Novel Protein sim. GBank gi|3122213|sp|O26327|HISX_METTH -		dehydrogenase	1014
		HISTIDINOL DEHYDROGENASE (HDH)
163	12904364 (7385, 7386)	Novel Protein sim. GBank gi|3122572|sp|Q43644|NUAM_SOLTU - NADH-		dehydrogenase	1028, 1047
		UBIQUINONE OXIDOREDUCTASE 75 KD SUBUNIT PRECURSOR
		(COMPLEX I-75 KD) (CI-75 KD) (76 KD MITOCHONDRIAL COMPLEX I
		SUBUNIT)
164	87896233 (6323, 6324)	Novel Protein sim. GBank gi|3273341|dbj|BAA31212| - (AB015756)		dehydrogenase	1013
		succinate dehydrogenase flavoprotein subunit [Rhodospirillum rubrum]
165	27831414 (5715, 5716)	Novel Protein sim. GBank gi|3879684|emb|CAA98524| - (Z74042)		dehydrogenase	1003
		predicted using Genefinder; Similarity to Haemophilus 3-oxoacyl-(acyl-
		carrier protein) reductase (SW; FABG_HAEIN); cDNA EST yk470b2.3
		comes from this gene; cDNA EST yk470b2.5 comes from this gene
		[Caenorhabditis elegans]
166	46857309 (7981, 7982)	Novel Protein sim. GBank gi|3914212|sp|P97608|OPLA_RAT - 5-		dehydrogenase	1000
		OXOPROLINASE (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-
		OPASE)
167	78367967 (2079, 2080)	Novel Protein sim. GBank gi|3928680|gb|AAC79659| - (AF068264) NAD+		dehydrogenase	1041
		dependent acetaldehyde dehydrogenase [Pseudomonas aeruginosa]
168	56151069 (639, 640)	Novel Protein sim. GBank gi|4154555 (AE001444) - Proline/pyrroline-5-		dehydrogenase	1041
		carboxylate dehydrogenase [Helicobacter pylori J99]
169	10856009 (4565, 4566)	Novel Protein sim. GBank gi|4512377|dbj|BAA75341.1| - (AB011837)		dehydrogenase	1001
		sorbitol dehydrogenase [Bacillus halodurans]
170	17673620 (8087, 8088)	Novel Protein sim. GBank gi|4574121|gb|AAD23901.1|AF00941 -		dehydrogenase	1006
		(AF009415) choline dehydrogenase [Staphylococcus xylosus]
171	11122707 (1669, 1670)	Novel Protein sim. GBank gi|464254|sp|P34942|NUDM_BOVIN - NADH-		dehydrogenase	1031
		UBIQUINONE OXIDOREDUCTASE 42 KD SUBUNIT PRECURSOR
		(COMPLEX I-42 KD) (CI-42 KD)
172	20430075 (8617, 8618)	Novel Protein sim. GBank gi|4835329|emb|CAB42951.1| - (AL049863)		dehydrogenase	1008
		putative dehydrogenase/reductase [Streptomyces coelicolor]
173	66314518 (8277, 8278)	Novel Protein sim. GBank gi|4894690|gb|AAD32592.1|AF12672 -		dehydrogenase	1014
		(AF126720) homoserine dehydrogenase [Mycobacterium smegmatis]
174	35819353 (2899, 2900)	Novel Protein sim. GBank gi|4982213|gb|AAD36707.1|AE00180 -		dehydrogenase	1014
		(AE001806) glutamate synthase, beta subunit [Thermotoga maritima]
175	80059042 (6813, 6814)	Novel Protein sim. GBank gi|5042272|emb|CAB44526.1| - (AL078618)		dehydrogenase	1022
		nuoF, NADH dehydrogenase subunit [Streptomyces coelicolor]
176	19523405 (4467, 4468)	Novel Protein sim. GBank gi|5042273|emb|CAB44527.1| - (AL078618)		dehydrogenase	1020
		nuoE, NADH dehydrogenase subunit [Streptomyces coelicolor]
177	80248762 (1519, 1520)	Novel Protein sim. GBank gi|5042274|emb|CAB44528.1| - (AL078618)		dehydrogenase	1004, 1021, 1023, 1041,
		nuoD, NADH dehydrogenase subunit [Streptomyces coelicolor]			1046
178	80079093 (165, 166)	Novel Protein sim. GBank gi|5139562|emb|CAB45580.1| - (AL079355)		dehydrogenase	1031
		putative glutathione-dependent aldehyde dehydrogenase [Streptomyces
		coelicolor]
179	20285943 (1751, 1752)	Novel Protein sim. GBank gi|544104|sp|Q02861|CRTI_MYXXA -		dehydrogenase	1031
		PHYTOENE DEHYDROGENASE (PHYTOENE DESATURASE)
180	11686851 (8753, 8754)	Novel Protein sim. GBank gi|5441779|emb|CAB46803.1| - (AL096811)		dehydrogenase	1028
		putative alcohol dehydrogenase (zinc-binding) [Streptomyces coelicolor
		A3(2)]
181	52561186 (7085, 7086)	Novel Protein sim. GBank gi|5459146|emb|CAB50632.1| - (AJ248288)		dehydrogenase	1004, 1010, 1028
		PAB1214 [Pyrococcus abyssl]
182	29002226 (321, 322)	Novel Protein sim. GBank gi|5508821|gb|AAD43988.1|U59485_-		dehydrogenase	1036
		(U59485) AttK [Agrobacterium tumefaciens]
183	82448116 (6627, 6628)	Novel Protein sim. GBank gi|584729|sp|P38113|ADH5_YEAST -		dehydrogenase	1001, 1002, 1004, 1006,
		ALCOHOL DEHYDROGENASE V			1021, 1022, 1031, 1036
184	54995204 (7321, 7322)	Novel Protein sim. GBank gi|585754|sp|P24217|PTFA_ECOLI - PTS		dehydrogenase	1026
		SYSTEM, FRUCTOSE-SPECIFIC IIA/FPR COMPONENT (EIIA-FRU)
		(FRUCTOSE-PERMEASE IIA/FPR COMPONENT)
		(PHOSPHOTRANSFERASE ENZYME II, A/FPR COMPONENT)
		(PHOSPHOTRANSFERASE FPR PROTEIN) (PSEUDO-HPR) (EIII-FRU)
		(FRUCTOSE PTS DIPHO . . .
185	11073062 (8759, 8760)	Novel Protein sim. GBank gi|699253 (U15183) - lipoamide dehydrogenase		dehydrogenase	1031
		[Mycobacterium leprae]
186	80478752 (5455, 5456)	Novel Protein sim. GBank gi|731294|sp|P39713|YAG1_YEAST -		dehydrogenase	1002, 1004, 1006, 1010,
		HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE			1020, 1021, 1024, 1031,
		PROTEIN IN GDH3-CNE1 INTERGENIC REGION			1041
187	86464887 (1413, 1414)	Novel Protein sim. GBank gi|757827|emb|CAA86041| - (Z37980) 5-		dehydrogenase	1026
		carboxy-2-hydroxymuconate semialdehyde dehydrogenase [Escherichia
		coli]
188	23307700 (1189, 1190)	Novel Protein sim. GBank gi|1169601|sp|P46312|FD6C_ARATH -	Contains protein domain	desaturase	1015
		OMEGA-6 FATTY ACID DESATURASE, CHLOROPLAST PRECURSOR	(PF00487) - Fatty acid desaturase
189	29000956 (7711, 7712)	Novel Protein sim. GBank gi|1345970|sp|P48620|FD3C_SESIN - OMEGA-	Contains protein domain	desaturase	1015
		3 FATTY ACID DESATURASE, CHLOROPLAST PRECURSOR	(PF00487) - Fatty acid desaturase
190	28846340 (2499, 2500)	Novel Protein sim. GBank gi|4240305|dbj|BAA74931.1| - (AB020715)		desaturase	1024
		KIAA0908 protein [Homo sapiens]
191	35893288 (1739, 1740)	Novel Protein sim. GBank gi|253181|bbs|110564 - NSR1=nucleolin	Contains protein domain	dna_ma_bind	1050
		homolog [Saccharomyces cerevisiae, Peptide, 249 aa]	(PF00076) - RNA recognition
			motif. (a.k.a. RRM, RBD, or RNP
			domain)
192	82460888 (5623, 5624)	Novel Protein sim. GBank gi|1723819|sp|P53186|YGD4_YEAST -	Contains protein domain	dna_ma_bind	1001, 1004, 1006, 1021,
		HYPOTHETICAL 13.6 KD PROTEIN IN MIG1-AGA2 INTERGENIC	(PF00096) - Zinc finger, C2H2		1035
		REGION	type
193	80039350 (5571, 5572)	Novel Protein sim. GBank gi|2315332 (AF016437) - contains similarity to	Contains protein domain	dna_ma_bind	1022, 1031
		a C2H2-type zinc finger [Caenorhabditis elegans]	(PF00096) - Zinc finger, C2H2
			type
194	27932691 (1633, 1634)	Novel Protein sim. GBank gi|2645674 (AF031955) - krupple-related zinc	Contains protein domain	dna_ma_bind	1003
		finger protein [Mus musculus]	(PF00096) - Zinc finger, C2H2
			type
195	80500321 (6689, 6690)	Novel Protein sim. GBank gi|3437|emb|CAA39084| - (X55442) MIG1	Contains protein domain	dna_ma_bind	1001, 1002, 1003, 1004,
		[Saccharomyces cerevisiae]	(PF00096) - Zinc finger, C2H2		1006, 1007, 1008, 1010,
			type		1015, 1020, 1021, 1022,
					1024, 1028, 1031, 1036,
					1041
196	33202227 (4465, 4466)	Novel Protein sim. GBank gi|3808293 (AF072440) - nitrogen regulatory	Contains protein domain	dna_ma_bind	1024
		protein [Enterobacter gergoviae]	(PF00158) - Sigma-54
			transcription factors
197	78761151 (8025, 8026)	Novel Protein sim. GBank gi|729736|sp|P40619|HMGL_PHANI - HMG1/2-	Contains protein domain	dna_ma_bind	1015
		LIKE PROTEIN	(PF00505) - HMG (high mobility
			group) box
198	80206269 (845, 846)	Novel Protein sim. GBank gi|1082703|pir||S52491 - polyadenylate binding		dna_ma_bind	1031
		protein II - human
199	21146786 (471, 472)	Novel Protein sim. GBank gi|1199536|emb|CAA64900| - (X95644) ORF		dna_ma_bind	1020, 1055
		2310 [Saccharomyces cerevisiae]
200	13517837 (1395, 1396)	Novel Protein sim. GBank gi|131639|sp|P15639|PUR9_ECOLI -		dna_ma_bind	1022
		PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE
		FORMYLTRANSFERASE (AICAR TRANSFORMYLASE)/IMP
		CYCLOHYDROLASE (INOSINICASE) (IMP SYNTHETASE) (ATIC)
201	27805718 (6373, 6374)	Novel Protein sim. GBank gi|133144|sp|P25299|RN15_YEAST - MRNA 3′-		dna_ma_bind	1003
		END PROCESSING PROTEIN RNA15
202	78754079 (6227, 6228)	Novel Protein sim. GBank gi|172372 (M58728) - DNA-binding protein		dna_ma_bind	1006
		[Saccharomyces cerevisiae]
203	10246066 (5745, 5746)	Novel Protein sim. GBank gi|1723880|sp|P53152|YGI7_YEAST -		dna_ma_bind	1004
		HYPOTHETICAL 15.5 KD PROTEIN IN MFAL2-MAD1 INTERGENIC
		REGION
204	78670380 (5097, 5098)	Novel Protein sim. GBank gi|2072966 (U93570) - p40 [Homo sapiens]		dna_ma_bind	1024
205	20465780 (5303, 5304)	Novel Protein sim. GBank gi|2506359|sp|P36659|CBPA_ECOLI -		dna_ma_bind	1008
		CURVED DNA-BINDING PROTEIN
206	32291638 (7925, 7926)	Novel Protein sim. GBank gi|3510645 (AF051348) - putative REX-2 [Mus		dna_ma_bind	1000
		musculus]
207	88098784 (8799, 8800)	Novel Protein sim. GBank gi|4115925 (AF118222) - contains similarity to		dna_ma_bind	1022, 1023
		RNA recognition motifs (Pfam: PF00076, Score=5.5e−23, N=2)
		[Arabidopsis thaliana]
208	10885749 (733, 734)	Novel Protein sim. GBank gi|4455696|emb|CAB36671| - (AL035500)		dna_ma_bind	1022
		putative phosphoribosylaminoimidazolecarboxamide formyltransferase
		[Mycobacterium leprae]
209	10886522 (1471, 1472)	Novel Protein sim. GBank gi|480289|pir||S36629 - polypyrimidine tract-		dna_ma_bind	1020
		binding protein - rat (fragment)
210	57295904 (5235, 5236)	Novel Protein sim. GBank gi|5052081|gb|AAD38426.1|AF08256 -		dna_ma_bind	1020
		(AF082568) zinc finger type transcription factor MZF-3 [Mus musculus]
211	80049357 (3737, 3738)	Novel Protein sim. GBank gi|116230|sp|P28598|CH60_BACSU - 60 KD	Contains protein domain	eph	1006, 1008, 1015
		CHAPERONIN (PROTEIN CPN60) (GROEL PROTEIN)	(PF00118) - TCP-1/cpn60
			chaperonin family
212	79199664 (6883, 6884)	Novel Protein sim. GBank gi|2980899|dbj|BAA25207| - (AB008137)	Contains protein domain	eph	1022
		similar to GroEL protein; stress protein [Enterobacter asburiae]	(PF00118) - TCP-1/cpn60
			chaperonin family
213	78916267 (287, 288)	Novel Protein sim. GBank gi|116194|sp|P19422|CH10_COXBU - 10 KD	Contains protein domain	eph	1036
		CHAPERONIN (PROTEIN CPN10) (PROTEIN GROES) (HEAT SHOCK	(PF00166) - Chaperonins 10 Kd
		PROTEIN A)	subunit
214	16792310 (3929, 3930)	Novel Protein sim. GBank gi|2267597 (AF009413) - 10 kDa chaperonin	Contains protein domain	eph	1041
		[Oryza sativa]	(PF00166) - Chaperonins 10 Kd
			subunit
215	20730763 (5597, 5598)	Novel Protein sim. GBank gi|123726|sp|P10413|HTPG_ECOLI - HEAT	Contains protein domain	eph	1004
		SHOCK PROTEIN HTPG (HIGH TEMPERATURE PROTEIN G) (HEAT	(PF00183) - Hsp90 protein
		SHOCK PROTEIN C62.5)
216	47652740 (7019, 7020)	Novel Protein sim. GBank gi|298028|emb|CAA50548| - (X71416) TOR2	Contains protein domain	eph	1026
		[Saccharomyces cerevisiae]	(PF00454) - Phosphatidylinositol
			3-and 4-kinases
217	27835670 (4727, 4728)	Novel Protein sim. GBank gi|586048|sp|P37297|STT4_YEAST -	Contains protein domain	eph	1004
		PHOSPHATIDYLINOSITOL 4-KINASE STT4 (PI4-KINASE) (PTDINS-4-	(PF00454) - Phosphatidylinositol
		KINASE)	3-and 4-kinases
218	36852700 (8573, 8574)	Novel Protein sim. GBank gi|138852|sp|P26537|VL1_HPV5B - MAJOR	Contains protein domain	eph	1050
		CAPSID PROTEIN L1	(PF00500) - L1 (late) protein
219	27847138 (2963, 2964)	Novel Protein sim. GBank gi|1778689|dbj|BAA07344| - (D38146) B61	Contains protein domain	eph	1003
		[Mus musculus]	(PF00812) - Ephrin
220	17226904 (6837, 6838)	Novel Protein sim. GBank gi|1076758|pir||S49340 - heat-shock protein		eph	1036
		precursor - rye
221	57292707 (2473, 2474)	Novel Protein sim. GBank gi|134975|sp|P15705|STI1_YEAST - HEAT		eph	1002, 1003, 1004, 1020,
		SHOCK PROTEIN STI1			1022, 1031
222	78391154 (4957, 4958)	Novel Protein sim. GBank gi|139216|sp|P22543|VP34_YEAST -		eph	1024
		PHOSPHATIDYLINOSITOL 3-KINASE VPS34 (PI3-KINASE) (PTDINS-3-
		KINASE) (PI3K) (VACUOLAR SORTING PROTEIN 34)
223	20385928 (6571, 6572)	Novel Protein sim. GBank gi|2314540|gb|AAD08413.1| - (AE000637) type		eph	1003
		III restriction enzyme M protein (mod) [Helicobacter pylori 26695]
224	23227180 (1995, 1996)	Novel Protein sim. GBank gi|298028|emb|CAA50548| - (X71416) TOR2		eph	1006
		[Saccharomyces cerevisiae]
225	11076446 (1791, 1792)	Novel Protein sim. GBank gi|3261784|emb|CAB08997| - (Z95558) htpX		eph	1008
		[Mycobacterium tuberculosis]
226	10309804 (7423, 7424)	Novel Protein sim. GBank gi|4001713|dbj|BAA35087.1| - (AB015879)		eph	1036
		DnaK [Porphyromonas gingivalis]
227	29346941 (241, 242)	Novel Protein sim. GBank gi|450880|emb|CAA54419| - (X77199) heat		eph	1020
		shock cognate 70-1 [Arabidopsis thaliana]
228	19903931 (1717, 1718)	Novel Protein sim. GBank gi|462047|sp|P34756|FAB1_YEAST -		eph	1004, 1008
		PROBABLE PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE FAB1
		(1-PHOSPHATIDYLINOSITOL-4-PHOSPHATE KINASE) (PIP5K)
		(PTDINS(4)P-5-KINASE) (DIPHOSPHOINOSITIDE KINASE)
229	39371506 (271, 272)	Novel Protein sim. GBank gi|493719|dbj|BAA02869| - (D13716) ‘multicopy		eph	1031
		suppressor of stt4 mutation (MSS4)’ [Saccharomyces cerevisiae]
230	8489130 (5273, 5274)	Novel Protein sim. GBank gi|729924|sp|P39518|LCF2_YEAST - LONG-		eph	1020
		CHAIN-FATTY-ACID - COA LIGASE 2 (LONG-CHAIN ACYL-COA
		SYNTHETASE 2) (FATTY ACID ACTIVATOR 2)
231	79619722 (7805, 7806)	Novel Protein sim. GBank gi|295642 (L13036) - phospholipase C	Contains protein domain	esterase	1023
		[Saccharomyces cerevisiae]	(PF00388) - Phosphatidytlinositol-
			specific phospholipase C, X
			domain
232	20289969 (5309, 5310)	Novel Protein sim. GBank gi|1151158 (U43145) - repeat organellar protein		esterase	1031
		[Plasmodium chabaudi]
233	14999633 (4685, 4686)	Novel Protein sim. GBank gi|2619052 (AF027868)—acyl carrier protein		esterase	1025
		phosphodiesterase [Bacillus subtilis]
234	79863644 (1899, 1900)	Novel Protein sim. GBank gi|2895717|emb|CAA04932| - (AJ001694)		esterase	1010
		esterase [Thermotoga maritima]
235	71116588 (7275, 7276)	Novel Protein sim. GBank gi|3445486|dbj|BAA32434| - (AB010428) acyl-		esterase	1020, 1031
		CoA hydrolase [Rattus norvegicus]
236	65645802 (5277, 5278)	Novel Protein sim. GBank gi|3880999|emb|CAA16386.1| - (AL021492)		esterase	1038, 1055
		Y45F10D.11 [Caenorhabditis elegans]
237	80248787 (5233, 5234)	Novel Protein sim. GBank gi|5360854|dbj|BAA82224.1| - (D86934)		esterase	1004, 1020, 1021, 1022,
		glycerophosphoryldiester phosphodiesterase [Staphylococcus aureus]			1024
238	42942441 (3449, 3450)	Novel Protein sim. GBank gi|5689908|emb|CAB52071.1| - (AL109732)		esterase	1001
		putative nucleotidase [Streptomyces coellcolor A3(2)]
239	79579759 (9009, 9010)			esterase	1020
240	79574436(799, 800)	Novel Protein sim. GBank gi|2113986|emb|CAB08991| - (Z95558) hemL	Contains protein domain	gaba	1028
		[Mycobacterium tuberculosis]	(PF00202) - Aminotransferases
			class-III pyridoxal-phosphate
241	80029128 (3813, 3814)	Novel Protein sim. GBank gi|4007739|emb|CAA22423| - (AL034447)	Contains protein domain	glucoamylase	1008, 1015, 1020, 1022,
		putative prokaryotic docking protein [Streptomyces coelicolor]	(PF00448) - SRP54-type protein		1024, 1031
242	70949031 (5719, 5720)	Novel Protein sim. GBank gi|584839|sp|P05804|BGLR_ECOLI - BETA-		glucuronidase	1026
		GLUCURONIDASE (GUS) (BETA-D-GLUCURONOSIDE
		GLUCURONOSOHYDROLASE)
243	37815363 (5439, 5440)	Novel Protein sim. GBank gi|2315985 (U83139) - mucin [Rattus	Contains protein domain	glycoprotein	1055
		norvegicus]	(PF00007) - Cystine-knot domain
244	78510710 (2077, 2078)	Novel Protein sim. GBank gi|1172451|sp|Q05793|PGBM_MOUSE -	Contains protein domain	glycoprotein	1006
		BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE	(PF00047) - Immunoglobulin
		PROTEOGLYCAN CORE PROTEIN PRECURSOR (HSPG) (PERLECAN)	domain
		(PLC)
245	29443439 (8925, 8926)	Novel Protein sim. GBank gi|112881|sp|P02764|A1AG_RAT - ALPHA-1-	Contains protein domain	glycoprotein	1024
		ACID GLYCOPROTEIN PRECURSOR (OROSOMUCOID) (OMD)	(PF00061) - lipocalin
246	80241641 (3061, 3062)	Novel Protein sim. GBank gi|5032197|ref|NP_005718.1|pTSPA -	Contains protein domain	glycoprotein	1003, 1041
		tetraspan 1; Tspan-1	(PF00335) - 4 transmembrane
			segments integral membrane
			proteins
247	78722615 (3757, 3758)	Novel Protein sim. GBank gi|28501|pir||S27879 - secretory protein YM-1	Contains protein domain	glycoprotein	1020
		precursor - mouse	(PF00704) - Glycosyl hydrolases
			family 18
248	80068413 (5297, 5298)	Novel Protein sim. GBank gi|1076802|pir||S49915 - extensin-like protein-		glycoprotein	1031
		maize
249	15001403 (6307, 6308)	Novel Protein sim. GBank gi|116918|sp|P12960|CONT_MOUSE -		glycoprotein	1025
		CONTACTIN PRECURSOR (NEURAL CELL SURFACE PROTEIN F3)
250	10344766 (5399, 5400)	Novel Protein sim. GBank gi|1169730|sp|P42512|FPTA_PSEAE - FE(III)-		glycoprotein	1035
		PYOCHELIN RECEPTOR PRECURSOR
251	65691921 (1673, 1674)	Novel Protein sim. GBank gi|1172555|sp|P42055|POR4_SOLTU - 34 KD		glycoprotein	1007, 1055
		OUTER MITOCHONDRIAL MEMBRANE PROTEIN PORIN (VOLTAGE-
		DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN) (VDAC) (POM
		34)
252	6419932 (2115, 2116)	Novel Protein sim. GBank gi|117437|sp|P08369|CRED_ECOLI - INNER		glycoprotein	1055
		MEMBRANE PROTEIN CRED
253	80098114 (2265,2266)	Novel Protein sim. GBank gi|1175955|sp|P43553|ALR2_YEAST -		glycoprotein	1003,1007,1015, 1023,
		ALUMINIUM RESISTANCE PROTEIN 2			1031
254	79793962 (8399, 8400)	Novel Protein sim. GBank gi|1176192|sp|P45420|YHCD_ECOLI -		glycoprotein	1002, 1021, 1036, 1041,
		HYPOTHETICAL OUTER MEMBRANE USHER PROTEIN IN GLTF-			1055
		NANT INTERGENIC REGION PRECURSOR
255	79614536 (1639, 1640)	Novel Protein sim. GBank gi|119111|sp|P12978|EBN2_EBV - EBNA-2		glycoprotein	1021
		NUCLEAR PROTEIN
256	28979568 (8159, 8160)	Novel Protein sim. GBank gi|121534|sp|P11654|GP21_RAT - INTEGRAL		glycoprotein	1002, 1041
		MEMBRANE GLYCOPROTEIN GP210 PRECURSOR
257	29347857 (1099, 1100)	Novel Protein sim. GBank gi|123036|sp|P20059|HEMO_RAT -		glycoprotein	1007
		HEMOPEXIN PRECURSOR
258	17942317 (851, 852)	Novel Protein sim. GBank gi|124905|sp|P27772|IRGA_VIBCH - IRON-		glycoprotein	1036
		REGULATED OUTER MEMBRANE VIRULENCE PROTEIN
		PRECURSOR
259	20603835 (3013, 3014)	Novel Protein sim. GBank gi|1262291 (U51683) - OMP1 precursor		glycoprotein	1003
		[Bruceila abortus]
260	10029936 (8657, 8658)	Novel Protein sim. GBank gi|128372|sp|P04846|NLPA_ECOLI -		glycoprotein	1036
		LIPOPROTEIN-28 PRECURSOR
261	87115944 (6453, 6454)	Novel Protein sim. GBank gi|129115|sp|P23231|OM70_NEUCR -		glycoprotein	1023
		MITOCHONDRIAL PRECURSOR PROTEINS IMPORT RECEPTOR (72 KD
		MITOCHONDRIAL OUTER MEMBRANE PROTEIN)
		(MITOCHONDRIAL IMPORT RECEPTOR FOR THE ADP/ATP CARRIER)
		(TRANSLOCASE OF OUTER MEMBRANE TOM70)
262	66259299 (7819, 7820)	Novel Protein sim. GBank gi|131411|sp|P23853|PSPA_ECOLI - PHAGE		glycoprotein	1008
		SHOCK PROTEIN A
263	80062518 (6119, 6120)	Novel Protein sim. GBank gi|1742866|dbj|BAA15547| - (D90819) Inner		glycoprotein	1008, 1022
		membrane protein MalK [Escherichia coli]
264	27824060 (3059, 3060)	Novel Protein sim. GBank gi|185498 (M99609) - immunoglobulin heavy		glycoprotein	1003
		chain [Homo sapiens]
265	80049539 (1207, 1208)	Novel Protein sim. GBank gi|2408014|emb|CAB16212.1| - (Z99162)		glycoprotein	1008
		putative membrane protein [Schizosaccharomyces pombe]
266	78788165 (2821, 2822)	Novel Protein sim. GBank gi|2498489|sp|Q12328|IM22_YEAST -		glycoprotein	1007
		MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE
		SUBUNIT TIM22
267	79457147 (2021, 2022)	Novel Protein sim. GBank gi|2498901|sp|Q53956|SECF_STRCO -		glycoprotein	1021, 1028, 1051
		PROTEIN-EXPORT MEMBRANE PROTEIN SECF
268	13084379 (1575, 1576)	Novel Protein sim. GBank gi|2645844 (AF033849) - oprD2-like porin		glycoprotein	1022
		precursor [Pseudomonas aeruginosa]
269	79859532 (41, 42)	Novel Protein sim. GBank gi|2695967|emb|CAA15860| - (AL010186)		glycoprotein	1041
		mmpL10 [Mycobacterium tuberculosis]
270	79569245 (5011, 5012)	Novel Protein sim. GBank gi|3004655 (AF017777) - waclaw [Drosophila		glycoprotein	1031
		melanogaster]
271	28856491 (33, 34)	Novel Protein sim. GBank gi|3089614 (AF086791) - unknown		glycoprotein	1024
		[Zymomonas mobllis]
272	65900245 (1671, 1672)	Novel Protein sim. GBank gi|3283166 (AF057526) - erythrocyte		glycoprotein	1014, 1015, 1021, 1035,
		membrane protein Rh50 [Mus musculus]			1051
273	11356069 (8367, 8368)	Novel Protein sim. GBank gi|3329386 (AF038958) - synaptic glycoprotein		glycoprotein	1055
		SC2 spliced variant [Homo sapiens]
274	4556646 (5729, 5730)	Novel Protein sim. GBank gi|3522943|gb|AAC34225.1| - (AC004411)		glycoprotein	1055
		putative p-glycoprotein [Arabidopsis thaliana]
275	66052607 (6817, 6818)	Novel Protein sim. GBank gi|3914250|sp|Q51487|OPRM_PSEAE -		glycoprotein	1008
		OUTER MEMBRANE PROTEIN OPRM PRECURSOR
276	79765225 (3775, 3776)	Novel Protein sim. GBank gi|3915996|sp|P77196|YFCU_ECOLI -		glycoprotein	1006, 1015, 1041
		HYPOTHETICAL OUTER MEMBRANE USHER PROTEIN IN AROC-
		FADL INTERGENIC REGION PRECURSOR
277	13076403 (707, 708)	Novel Protein sim. GBank gi|399000|sp|P31223|ACRA_ECOLI -		glycoprotein	1022
		ACRIFLAVIN RESISTANCE PROTEIN A PRECURSOR
278	78794717 (1361, 1362)	Novel Protein sim. GBank gi|417231|sp|P32486|KRE6_YEAST - BETA-		glycoprotein	1007
		GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6 (KILLER TOXIN-
		RESISTANCE PROTEIN 6)
279	78470378 (5251, 5252)	Novel Protein sim. GBank gi|4467970|emb|CAB37973| - (X76640)		glycoprotein	1024
		hypothetical protein [Myxococcus xanthus]
280	79617709 (3657, 3658)	Novel Protein sim. GBank gi|464504|sp|P33221|PURT_ECOLI-		glycoprotein	1001
		PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 (GART
		2) (GAR TRANSFORMYLASE 2) (5′-PHOSPHORIBOSYLGLYCINAMIDE
		TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR
		TRANSFORMYLASE)
281	78965170 (1401, 1402)	Novel Protein sim. GBank gi|479628|pir||S34969 - porin E1 -		glycoprotein	1036
		Pseudomonas aeruginosa
282	39539204 (1335, 1336)	Novel Protein sim. GBank gi|485956|emb|CAA83635| - (Z32686) mrpC		glycoprotein	1021, 1041
		[Proteus mirabilis]
283	20294672 (4173, 4174)	Novel Protein sim. GBank gi|5453178|gb|AAD43467.1|AF11360 -		glycoprotein	1031
		(AF113608) UspA1 [Moraxella catarrhalis]
284	78381117 (993, 994)	Novel Protein sim. GBank gi|548514|sp|Q03180|PIR3_YEAST - PIR3		glycoprotein	1036
		PROTEIN PRECURSOR (COVALENTLY-LINKED CELL WALL PROTEIN
		8)
285	88094402 (6145, 6146)	Novel Protein sim. GBank gi|729491|sp|P30130|FIMD_ECOLI - OUTER		glycoprotein	1004
		MEMBRANE USHER PROTEIN FIMD PRECURSOR
286	78368900 (4929, 4930)	Novel Protein sim. GBank gi|887638|emb|CAA56302| - (X79979) CDS2		glycoprotein	1006
		[Streptomyces griseus]
287	71766874 (1869, 1870)			glycoprotein	1021, 1036
288	79627730 (6423, 6424)			glycoprotein	1023,1035
289	79262445 (2447, 2448)	Novel Protein sim. GBank gi|2132124|pir||S67208 - hypothetical protein	Contains protein domain	helicase	1036
		YOR304w - yeast (Saccharomyces cerevisiae)	(PF00176) - SNF2 and others N-
			terminal domain
290	77801272 (2849, 2850)	Novel Protein sim. GBank gi|3158516 (AF067617) - contains similarity to	Contains protein domain	helicase	1051
		chromo (chromatin organization modifier) domains (Pfam: chromo.hmm.	(PF00176) - SNF2 and others N-
		score: 17.76 and 27.94) and to helicases conserved C-terminal domain	terminal domain
		(Pfam: helicase_C.hmm, score: 67.00) [Caenorhabditis elegans]
291	79179202 (8791, 8792)	Novel Protein sim. GBank gi|1172894|sp|P43809|RECG_HAEIN - ATP-	Contains protein domain	helicase	1025
		DEPENDENT DNA HELICASE RECG	(PF00270) - DEAD/DEAH box
			helicase
292	20465793 (7775, 7776)	Novel Protein sim. GBank gi|1351656|sp|Q09903|YAJ3_SCHPO -	Contains protein domain	helicase	1008
		PUTATIVE ATP-DEPENDENT RNA HELICASE C30D11.03	(PF00270) - DEAD/DEAH box
			helicase
293	30265520 (7737, 7738)	Novel Protein sim. GBank gi|4579744|dbj|BAA75085.1| - (AB017104)	Contains protein domain	helicase	1024
		DNA helicase Q1 [Mus musculus]	(PF00270) - DEAD/DEAH box
			helicase
294	80045298 (2723, 2724)	Novel Protein sim. GBank gi|5042262|emb|CAB44516.1| - (AL078618)	Contains protein domain	helicase	1008
		putative helicase [Streptomyces coelicolor]	(PF00270) - DEAD/DEAH box
			helicase
295	78674774 (4129, 4130)	Novel Protein sim. GBank gi|731740|sp|P38719|DBP8_YEAST -	Contains protein domain	helicase	1007
		PROBABLE ATP-DEPENDENT RNA HELICASE DBP8	(PF00270) - DEAD/DEAH box
			helicase
296	28489738 (7945, 7946)	Novel Protein sim. GBank gi|118411|sp|P06634|DED1_YEAST -	Contains protein domain	helicase	1006, 1020
		PUTATIVE ATP-DEPENDENT RNA HELICASE DED1	(PF00271) - Helicases conserved
			C-terminal domain
297	27370970 (1179, 1180)	Novel Protein sim. GBank gi|4454799|gb|AAD20980| - (AF079782)	Contains protein domain	helicase	1001, 1007
		translation initiation factor 4A2 [Zea mays]	(PF00271) - Helicases conserved
			C-terminal domain
298	8518066 (4179, 4180)	Novel Protein sim. GBank gi|2625021 (AF028736) - DNA helicase II	Contains protein domain	helicase	1020
		[Serratia marcescens]	(PF00430) - ATP synthase B/B'
			CF(0)
299	86462670 (7079, 7080)	Novel Protein sim. GBank gi|1084084|pir||S55811 - hrpA protein -		helicase	1023
		Escherichia coli
300	21437178 (7027, 7028)	Novel Protein sim. GBank gi|130804|sp|P20095|PR02_YEAST - PRE-		helicase	1020
		MRNA SPLICING FACTOR RNA HELICASE PRP2
301	94657426 (7855, 7856)	Novel Protein sim. GBank gi|130830|sp|P24384|PR22_YEAST - PRE-		helicase	1031
		MRNA SPLICING FACTOR RNA HELICASE PRP22
302	52561605 (8625, 8626)	Novel Protein sim. Gbank gi|132252|sp|P24230|RECG_ECOLI - ATP-		helicase	1002
		DEPENDENT DNA HELICASE RECG
303	80062482 (7, 8)	Novel Protein sim. GBank gi|134124|sp|P08577|RUVB_ECOLI -		helicase	1008
		HOLLIDAY JUNCTION DNA HELICASE RUVB
304	80062519 (6217, 6218)	Novel Protein sim. GBank gi|1718065|sp|P53528|UVRD_MYCLE -		helicase	1008, 1015, 1023, 1025,
		PUTATIVE DNA HELICASE II HOMOLOG			1028
305	19874303 (3989, 3990)	Novel Protein sim. GBank gi|172270 (M31524) - PRP16 peptide (put.		helicase	1020
		helicase): putative [Saccharomyces cerevisiae]
306	78488722 (3263, 3264)	Novel Protein sim. GBank gi|1742299|dbj|BAA15025| - (D90779) ATP-		helicase	1007
		dependent helicase HrpA homolog. [Escherichia coli]
307	13883890 (7339, 7340)	Novel Protein sim. GBank gi|2314653|gb|AAD08516.1| - (AE000647) DNA		helicase	1050
		helicase II (uvrD) [Helicobacter pylori 26695]
308	13886313 (7791, 7792)	Novel Protein sim. GBank gi|3121983|sp|O25916|DNAB_HELPY -		helicase	1050
		REPLICATIVE DNA HELICASE
309	78372173 (5241, 5242)	Novel Protein sim. GBank gi|3158516 (AF067617) - contains similarity to		helicase	1041
		chromo (chromatin organization modifier) domains (Pfam: chromo.hmm.
		score: 17.76 and 27.94) and to helicases conserved C-terminal domain
		(Pfam: helicase_C.hmm, score: 67.00) [Caenorhabditis elegans]
310	19464841 (3699, 3700)	Novel Protein sim. GBank gi|3249557 (AF010185) - DNA helicase II UvrD		helicase	1021
		[Pseudomonas aeruginosa]
311	80256570 (6075, 6076)	Novel Protein sim. GBank gi|4007725|emb|CAA22409| - (AL034447)		helicase	1004
		putative ATP-dependent DNA helicase [Streptomyces coellcolor]
312	32745469 (6609, 6610)	Novel Protein sim. GBank gi|407992 (L25125) - RNA helicase [Mus		helicase	1001
		musculus]
313	85818219 (6929, 6930)	Novel Protein sim. GBank gi|4104820|gb|AAD02177.1| - (AF040045)		helicase	1017
		DEAD box RNA helicase homolog [Anabaena variabilis]
314	78459902 (1355, 1356)	Novel Protein sim. GBank gi|416592|sp|P32323|AGA1_YEAST - A-		helicase	1024
		AGGLUTININ ATTACHMENT SUBUNIT PRECURSOR
315	82362354 (4511, 4512)	Novel Protein sim. GBank gi|417308|sp|P32333|MOT1_YEAST -		helicase	1001, 1002, 1003, 1004,
		PROBABLE HELICASE MOT1			1006, 1007, 1008, 1010,
					1015, 1020, 1021, 1022,
					1024, 1031, 1036, 1041,
					1047, 1051
316	65503301 (6055, 6056)	Novel Protein sim. GBank gi|4455689|emb|CAB36663| - (AL035500)		helicase	1046
		probable ATP-dependent DNA helicase [Mycobacterium leprae]
317	28489378 (7043, 7044)	Novel Protein sim. GBank gi|5102733|emb|CAB45191.1| - (AL079292)		hellcase	1024
		hypothetical protein, similar to (AC007017) putative RNA helicase A
		[Arabidopsis thaliana] [Homo sapiens]
318	10236105 (1505, 1506)	Novel Protein sim. GBank gi|548730|sp|P25888|RHLE_ECOLI -		helicase	1036
		PUTATIVE ATP-DEPENDENT RNA HELICASE RHLE
319	23285347 (4343, 4344)	Novel Protein sim. GBank gi|5689893|emb|CAB52056.1| - (AL109732)		helicase	1024
		putative ATP-bindlng RNA helicase [Streptomyces coelicolor A3(2)]
320	8492058 (6697, 6698)	Novel Protein sim. GBank gi|586550|sp|P38112|MAK5_YEAST - ATP-		helicase	1020
		DEPENDENT RNA HELICASE MAK5
321	80216307 (1237, 1238)	Novel Protein sim. GBank gi|731738|sp|P38859|DNA2_YEAST - DNA		helicase	1002, 1003, 1004, 1015,
		REPLICATION HELICASE DNA2			1020, 1022, 1031, 1036
322	21428417 (6511, 6512)	Novel Protein sim. GBank gi|95749|pir||S12698 - probable RNA helicase -		helicase	1004
		Escherichia coli
323	25267355 (2597, 2598)	Novel Protein sim. GBank gi|4240299|dbj|BAA74928.1| - (AB020712)	Contains protein domain	histone	1002
		KIAA0905 protein [Homo sapiens]	(PF00400) - WD domain, G-beta
			repeat
324	78781427 (7147, 7148)	Novel Protein sim. GBank gi|1710013|sp|P01119|RAS1_YEAST - RAS-		histone	1020
		LIKE PROTEIN 1
325	95292938 (149, 150)	Novel Protein sim. GBank gi|2984320 (AE000773) - acetoin utilization		histone	1008, 1022, 1031
		protein [Aquifex aeolicus]
326	80258853 (2643, 2644)	Novel Protein sim. GBank gi|3023317|sp|Q48935|APHA_MYCRA -		histone	1004
		ACETYLPOLYAMINE AMINOHYDROLASE
327	30190917 (299, 300)	Novel Protein sim. GBank gi|417103|sp|P11105|H32_MEDSA - HISTONE		histone	1007
		H3.2, MINOR
328	80223141 (5477, 5478)	Novel Protein sim. GBank gi|728956|sp|P35817|BDF1_YEAST - BDF1	Contains protein domain	homeobox	1003, 1004, 1020, 1031
		PROTEIN	(PF00439) - Bromodomain
329	11691396 (6919, 6920)	Novel Protein sim. GBank gi|127089|sp|P25336|MSH3_YEAST - MUTS	Contains protein domain	homeobox	1031
		PROTEIN HOMOLOG 3 (MISMATCH BINDING PROTEIN) (MBP)	(PF00488) - DNA mismatch repair
			proteins, mutS family
330	36756499 (2805, 2806)	Novel Protein sim. GBank gi|2494503|sp|Q63244|HFH1_RAT -		homeobox	1021, 1031
		HEPATOCYTE NUCLEAR FACTOR 3 FORKHEAD HOMOLOG 1 (HFH-1)
331	79178980 (1959, 1960)	Novel Protein sim. GBank gi|547726|sp|P35640|INVA_BARBA -	Contains protein domain	hydrolase	1025
		INVASION PROTEIN A	(PF00293) - Bacterial mutT
			protein
332	30578333 (7005, 7006)	Novel Protein sim. GBank gi|2880049 (AC002340) - hypothetical protein	Contains protein domain	hydrolase	1024
		[Arabidopsis thaliana]	(PF01662) - Cytosolic long-chain
			acyl-CoA thioester hydrolase
333	78477734 (5577, 5578)	Novel Protein sim. GBank gi|1130507 (L41670) - fumarylacetoacetate		hydrolase	1002
		hydrolase [Emericella nidulans]
334	86475776 (7507, 7508)	Novel Protein sim. GBank gi|115890|sp|P06621|CBPG_PSES6 -		hydrolase	1045
		CARBOXYPEPTIDASE G2 PRECURSOR (FOLATE HYDROLASE G2)
		(PTEROYLMONOGLUTAMIC ACID HYDROLASE G2) (GLUTAMATE
		CARBOXYPEPTIDASE)
335	86693482 (127, 128)	Novel Protein sim. GBank gi|1169528|sp|P42895|ENO2_MAIZE -		hydrolase	1005
		ENOLASE 2 (2-PHOSPHOGLYCERATE DEHYDRATASE 2) (2-
		PHOSPHO-D-GLYCERATE HYDRO-LYASE 2)
336	14999668 (6275, 6276)	Novel Protein sim. GBank gi|1169528|sp|P42895|ENO2_MAIZE -		hydrolase	1025
		ENOLASE 2 (2-PHOSPHOGLYCERATE DEHYDRATASE 2) (2-
		PHOSPHO-D-GLYCERATE HYDRO-LYASE 2)
337	79824931 (463, 464)	Novel Protein sim. GBank gi|1175303|sp|P44049|MLTC_HAEIN -		hydrolase	1006, 1020, 1041
		MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE C
		PRECURSOR (MUREIN HYDROLASE C)
338	79565170 (5587, 5588)	Novel Protein sim. GBank gi|1175620|sp|P42241|YCBI_BACSU -		hydrolase	1021
		HYPOTHETICAL 32.4 KD PROTEIN IN PCP 5′REGION (ORF8)
339	80218214 (183, 184)	Novel Protein sim. GBank gi|1708850|sp|Q10740|LKHA_YEAST -		hydrolase	1003, 1004, 1020, 1023,
		PROBABLE LEUKOTRIENE A-4 HYDROLASE (LTA-4 HYDROLASE)			1028
		(LEUKOTRIENE A(4) HYDROLASE)
340	27956251 (2771, 2772)	Novel Protein sim. GBank gi|1754515|dbj|BAA13413.1| - (D87515)		hydrolase	1003
		aminopeptidase-B [Rattus norvegicus]
341	17022381 (7037, 7038)	Novel Protein sim. GBank gi|2118299|pir||S67305 - ERR1 protein - yeast		hydrolase	1021
		(Saccharomyces cerevisiae)
342	56324337 (15, 16)	Novel Protein sim. GBank gi|2143818|pir||S59898 - kynureninase (EC		hydrolase	1024
		3.7.1.3) - rat
343	78934465 (3801, 3802)	Novel Protein sim. GBank gi|216807|dbj|BAA01524| - (D10678) 6-		hydrolase	1015
		aminohexanoate-dimer hydrolase [Pseudomonas sp.]
344	19886695 (363, 364)	Novel Protein sim. GBank gi|2842689|sp|Q92342|YDI4_SCHPO -		hydrolase	1031
		HYPOTHETICAL 50.4 KD PROTEIN C1F8.04C IN CHROMOSOME I
345	79557816 (3231, 3232)	Novel Protein sim. GBank gi|4467250|emb|CAB37575| - (AL035569)		hydrolase	1004, 1006, 1015, 1022
		probable Glu-tRNA Gln amidotransferase subunit [Streptomyces
		coelicolor]
346	29208398 (4199, 4200)	Novel Protein sim. GBank gi|4503585|ref|NP_001970.1|pEPHX - epoxide		hydrolase	1015
		hydrolase 2, cytoplasmic
347	80258207 (51, 52)	Novel Protein sim. GBank gi|4753869|emb|CAB42032.1| - (AL049754)		hydrolase	1004
		putative hydrolase [Streptomyces coelicolor]
348	17881519 (3397, 3398)	Novel Protein sim. GBank gi|5545316|dbj|BAA82531.1| - (AB030032)		hydrolase	1036
		putative transglycosylase [Actinobacillus actinomycetemcomitans]
349	25151365 (6343, 6344)	Novel Protein sim. GBank gi|5545316|dbj|BAA82531.1| - (AB030032)		hydrolase	1007
		putative transglycosylase [Actinobacillus actinomycetemcomitans]
350	17936810 (3529, 3530)	Novel Protein sim. GBank gi|731088|sp|P24215|UXUA_ECOLI -		hydrolase	1035
		MANNONATE DEHYDRATASE (D-MANNONATE HYDROLASE)
351	7415018 (1947, 1948)	Novel Protein sim. GBank gi|80437|pir||S18811 - urocanate hydratase		hydrolase	1055
		(EC 4.2.1.49) - Bacillus subtills (fragment)
352	55506625 (6841, 6842)	Novel Protein sim. GBank gi|4512301|dbj|BAA75048.1| - (AB019440)	Contains protein domain	immunoglob	1019
		immunogloblin heavy chain variable region [Homo sapiens]	(PF00047) - Immunoglobulin
			domain
353	80216144 (1887, 1888)	Novel Protein sim. GBank gi|619440 (M94115) - This CDS feature is	Contains protein domain	immunoglob	1022
		included to show the translation of the corresponding V_region. Presently	(PF00047) - Immunoglobulin
		translation qualifiers on V_region features are illegal. [Homo sapiens]	domain
354	10311869 (5331, 5332)	Novel Protein sim. GBank gi|3046410 (AF044419) - anti-Rh(D) antibody		immunoglob	1023
		VH segment [synthetic construct]
355	20405293 (4415, 4416)	Novel Protein sim. GBank gi|346088|pir||PH1282 - Ig heavy chain V		immunoglob	1022
		region (clone PBL13) - human (fragment)
356	80047082 (1441, 1442)	Novel Protein sim. GBank gi|481342|pir||S38489 - Ig heavy chain - human		immunoglob	1022
		(fragment)
357	94325418 (745, 746)	Novel Protein sim. GBank gi|4837863|gb|AAD30723.1| - (AF103163)		immunoglob	1041
		immunoglobulin heavy chain variable region [Homo sapiens]
358	80047715 (6499, 6500)	Novel Protein sim. GBank gi|3885336 (AC005623) - receptor-like protein	Contains protein domain	interleukinrecept	1002, 1020
		kinase [Arabidopsis thaliana]	(PF00069) - Eukaryotic protein
			kinase domain
359	80059851 (6101, 6102)	Novel Protein sim. GBank gi|4557753|ref|NP_000372.1|pMID1 - midline 1	Contains protein domain	interleukinrecept	1001, 1020
		protein	(PF00097) - Zinc finger, C3HC4
			type (RING finger)
360	80218527 (995, 996)	Novel Protein sim. GBank gi|416977|sp|P32474|EUG1_YEAST -	Contains protein domain	isomerase	1003, 1004, 1006, 1020,
		ENDOPLASMIC RETICULUM PROTEIN EUG1 PRECURSOR	(PF00085) - Thioredoxin		1022, 1031, 1041
		(POSSIBLE PROTEIN DISULFIDE ISOMERASE (PDI))
361	56013085 (4183, 4184)	Novel Protein sim. GBank gi|456013 (L28174) - disulfide-like protein	Contains protein domain	isomerase	1050
		[Acanthamoeba castellanli]	(PF00085) - Thioredoxin
362	78025291 (8709, 8710)	Novel Protein sim. GBank gi|1351280|sp|P48500|TPIS_RAT -	Contains protein domain	isomerase	1006
		TRIOSEPHOSPHATE ISOMERASE (TIM)	(PF00121) - Triosephosphate
			isomerase
363	66050272 (4971, 4972)	Novel Protein sim. GBank gi|1730003|sp|P50920|TPIS_MYCHY -	Contains protein domain	isomerase	1005
		TRIOSEPHOSPHATE ISOMERASE (TIM)	(PF00121) - Triosephosphate
			isomerase
364	11777004 (8235, 8236)	Novel Protein sim. GBank gi|1490397|emb|CAA91553| - (Z67740) DNA	Contains protein domain	isomerase	1020
		gyrase [Streptococcus pneumoniae]	(PF00204) - DNA topoisomerase
			II (N-terminal region)
365	87461104 (5413, 5414)	Novel Protein sim. GBank gi|4468641|emb|CAB38179| - (Y16286) gyrB	Contains protein domain	isomerase	1023
		[Pseudomonas aeruginosa]	(PF00204) - DNA topoisomerase
			II (N-terminal region)
366	86477775 (6527, 6528)	Novel Protein sim. GBank gi|1652134|dbj|BAA17058| - (D90903) FKBP-	Contains protein domain	isomerase	1017
		type peptidyl-prolyl cis-trans isomerase [Synechocystis sp.]	(PF00254) - FKBP-type peptidyl-
			prolyl cis-trans isomerases
367	10355882 (541, 542)	Novel Protein sim. GBank gi|478318|pir||JN0873 - immunophilin p59 -	Contains protein domain	isomerase	1036
		mouse	(PF00254) - FKBP-type peptidyl-
			prolyl cis-trans isomerases
368	79872191 (5327, 5328)	Novel Protein sim. GBank gi|239790|bbs|68264 - (S68257) D-xylulose	Contains protein domain	isomerase	1015
		keto-isomerase, D-glucose isomerase, D-xylose isomerase (EC 5.3.1.5)	(PF00259) - Xylose isomerase
		[Escherichia coli, Peptide, 440 aa] [Escherichia coli]
369	80105757 (4213, 4214)	Novel Protein sim. GBank gi|113158|sp|P25516|ACO1_ECOLI -	Contains protein domain	isomerase	1011
		ACONITATE HYDRATASE 1 (CITRATE HYDRO-LYASE 1) (ACONITASE	(PF00330) - Aconitase family
		1)	(aconitate hydratase)
370	32164388 (2025, 2026)	Novel Protein sim. GBank gi|1786259 (AE000117) - 3-isopropylmalate	Contains protein domain	isomerase	1021
		isomerase (dehydratase) subunit [Escherichia coli]	(PF00330) - Aconitase family
			(aconitate hydratase)
371	78980291 (8967, 8968)	Novel Protein sim. GBank gi|4406814|gb|AAD20122| - (AC006201)	Contains protein domain	isomerase	1002
		putative peptidyl-prolyl isomerase [Arabidopsis thaliana]	(PF00639) - PPIC-type PPIASE
			domain.
372	65327341 (2415, 2416)	Novel Protein sim. GBank gi|400187|sp|Q02144|LEUD_LACLA - 3-	Contains protein domain	isomerase	1020
		ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT	(PF00694) - Aconitase C-terminal
		(ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE)	domain
373	16388095 (2969, 2970)	Novel Protein sim. GBank gi|2126788|pir||I40190 - DNA topoisomerase I -	Contains protein domain	isomerase	1002
		Bacillus firmus (fragment)	(PF01131) - Prokaryotic DNA
			topoisomerase
374	80491857 (3457, 3458)	Novel Protein sim. GBank gi|1174735|sp|P43012|TOP1_HAEIN - DNA	Contains protein domain	isomerase	1010
		TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME)	(PF01398) - Topoisomerase DNA
		(UNTWISTING ENZYME) (SWIVELASE)	binding C4 zinc finger
375	79316780 (887, 888)	Novel Protein sim. GBank gi|114100|sp|P08203|ARAD_ECOLI - L-		isomerase	1004, 1020
		RIBULOSE-5-PHOSPHATE 4-EPIMERASE
376	79312879 (6797, 6798)	Novel Protein sim. GBank gi|116841|sp|P21640|COBJ_PSEDE -		isomerase	1008
		PRECORRIN-3B C17-METHYLTRANSFERASE (PRECORRIN-3
		METHYLTRANSFERASE) (PRECORRIN-3 METHYLASE)
377	79193215 (7677, 7678)	Novel Protein sim. GBank gi|1169225|sp|P44859|DAPF_HAEIN -		isomerase	1022
		DIAMINOPIMELATE EPIMERASE
378	90936817 (25, 26)	Novel Protein sim. GBank gi|119120|sp|P07896|ECHP_RAT - ENOYL-		isomerase	1018
		COA HYDRATASE/3,2-TRANS-ENOYL-COA ISOMERASE/3-
		HYDROXYACYL-COA DEHYDROGENASE , PEROXISOMAL
		(PEROXISOMAL BIFUNCTONAL ENZYME) (PBE) (PBFE)
379	79244172 (7479, 7480)	Novel Protein sim. GBank gi|1353104|sp|P48561|TRF5_YEAST -		isomerase	1006
		TOPOISOMERASE 1-RELATED PROTEIN TRF5
380	80429067 (8217, 8218)	Novel Protein sim. GBank gi|1706568|sp|Q10533|ECHH_MYCTU -		isomerase	1000, 1004, 1008, 1010,
		PUTATIVE ENOYL-COA HYDRATASE			1035
381	20385447 (3541, 3542)	Novel Protein sim. GBank gi|1706702|sp|P52641|EPSC_BURSO -		isomerase	1003
		PUTATIVE UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (UDP-
		GLCNAC-2-EPIMERASE)
382	80481824 (377, 378)	Novel Protein sim. GBank gi|1929095|emb|CAA72944| - (Y12268) DapF		isomerase	1010
		protein [Pseudomonas fluorescens]
383	33202071 (3873, 3874)	Novel Protein sim. GBank gi|2231748 (U92221) - macrophage infectivity		isomerase	1024
		potentiator [Legionella shakespearei]
384	78907625 (2455, 2456)	Novel Protein sim. GBank gi2494040|sp|Q51564|DAPF_PSEAE -		isomerase	1036
		DIAMINOPIMELATE EPIMERASE
385	54992976 (1259, 1260)	Novel Protein sim. GBank gi|2501240|sp|Q59567|TOP1_MYCTU - DNA		isomerase	1026
		TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME)
		(UNTWISTING ENZYME) (SWIVELASE)
386	82450231 (8827, 8828)	Novel Protein sim. GBank gi|2621713 (AE000844) - UDP-glucose 4-		isomerase	1001, 1003, 1004, 1008,
		epimerase [Methanobacterium thermoautotrophicum]			1010, 1020, 1021, 1031
387	16837298 (1907, 1908)	Novel Protein sim. GBank gi|2739168 (AF032386) - aldose-1-epimerase-		isomerase	1021
		like protein [Nicotiana tabacum]
388	10187377 (6783, 6784)	Novel Protein sim. GBank gi|3309243 (AF073507) - aconitase-iron		isomerase	1002
		regulated protein 1 [Citrus limon]
389	80215263 (7477, 7478)	Novel Protein sim. GBank gi|4502327|ref|NP_001689.1|pAUH| - AU RNA-		isomerase	1002, 1008, 1024
		binding protein/enoyl-Coenzyme A hydratase precursor
390	78792960 (7867, 7868)	Novel Protein sim. GBank gi|4520378|dbj|BAA75914.1| - (AB024602)		isomerase	1020
		NIFS-like protein [Pseudomonas putida]
391	17087020 (2905, 2906)	Novel Protein sim. GBank gi|728783|sp|P39533|ACOX_YEAST -		isomerase	1036
		PUTATIVE ACONITASE IN PRP21-UBP12 INTERGENIC REGION
392	79864827 (1301, 1302)	Novel Protein sim. GBank gi|1170625|sp|P27466|KCC1_YEAST -	Contains protein domain	kinase	1015, 1022, 1035, 1036
		CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE I	(PF00069) - Eukaryotic protein
			kinase domain
393	78781757 (5949, 5950)	Novel Protein sim. GBank gi|1170714|sp|P43289|KSGG_ARATH -	Contains protein domain	kinase	1006
		SHAGGY RELATED PROTEIN KINASE ASK-GAMMA	(PF00069) - Eukaryotic protein
			kinase domain
394	82136936 (5067, 5068)	Novel Protein sim. GBank gi|1173459|sp|P41808|SMK1_YEAST -	Contains protein domain	kinase	1014
		SPORULATION-SPECIFIC MITOGEN-ACTIVATED PROTEIN KINASE	(PF00069) - Eukaryotic protein
		SMK1 (MAP KINASE SMK1)	kinase domain
395	16383607 (5269, 5270)	Novel Protein sim. GBank gi|125288|sp|P15791|KCCD_RAT -	Contains protein domain	kinase	1015
		CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II	(PF00069) - Eukaryotic protein
		DELTA CHAIN (CAM-KINASE II DELTA CHAIN) (CAMK-II, DELTA	kinase domain
		SUBUNIT)
396	56660366 (2363, 2364)	Novel Protein sim. GBank gi|2062399 (U78857) - protein serine/threonine	Contains protein domain	kinase	1037, 1039
		kinase CPG16 [Rattus norvegicus]	(PF00069) - Eukaryotic protein
			kinase domain
397	13089154 (6433, 6434)	Novel Protein sim. GBank gi|2078052|emb|CAB08487.1| - (Z95209) pknD	Contains protein domain	kinase	1025
		[Mycobacterium tuberculosis]	(PF00069) - Eukaryotic protein
			kinase domain
398	79601611 (3255, 3256)	Novel Protein sim. GBank gi|2131510|pir||S69634 - hypothetical protein	Contains protein domain	kinase	1004
		YDR466w - yeast (Saccharomyces cerevisiae)	(PF00069) - Eukaryotic protein
			kinase domain
399	79817329 (5083, 5084)	Novel Protein sim. GBank gi|2392895 (AF017056) - brassinosteroid	Contains protein domain	kinase	1036
		insensitive 1 [Arabidopsis thaliana]	(PF00069) - Eukaryotic protein
			kinase domain
400	65691019 (367, 368)	Novel Protein sim. GBank gi|2781357 (AC003113) - F24O1.13	Contains protein domain	kinase	1007
		[Arabidopsis thaliana]	(PF00069) - Eukaryotic protein
			kinase domain
401	79250602 (9037, 9038)	Novel Protein sim. GBank gi|3522961|gb|AAC34243.1| - (AC004411)	Contains protein domain	kinase	1036
		putative pto kinase [Arabidopsis thaliana]	(PF00069) - Eukaryotic protein
			kinase domain
402	20432709 (8947, 8948)	Novel Protein sim. GBank gi|3522970 (U42390) - Trio [Homo sapiens]	Contains protein domain	kinase	1020
			(PF00069) - Eukaryotic protein
			kinase domain
403	29510031 (6243, 6244)	Novel Protein sim. GBank gi|3600036 (AF080119) - contains similarity to	Contains protein domain	kinase	1006
		protein kinase domains (Pfam: pkinase.hmm, score: 227.04) [Arabidopsis	(PF00069) - Eukaryotic protein
		thaliana]	kinase domain
404	95414355 (2403, 2404)	Novel Protein sim. GBank gi|4210753|emb|CAA10713| - (AJ132604)	Contains protein domain	kinase	1020, 1022, 1040, 1055
		hypothetical protein [Lactococcus lactis]	(PF00069) - Eukaryotic protein
			kinase domain
405	78825843 (7951, 7952)	Novel Protein sim. GBank gi|4467134|emb|CAB37503| - (AL035540)	Contains protein domain	kinase	1015
		protein kinase like protein [Arabidopsis thaliana]	(PF00069) - Eukaryotic protein
			kinase domain
406	37001545 (7189, 7190)	Novel Protein sim. GBank gi|4490638|emb|CAA92266.2| - (Z68144)	Contains protein domain	kinase	1001
		serine/threonine protein kinase [Schizosaccharomyces pombe]	(PF00069) - Eukaryotic protein
			kinase domain
407	65891548 (6585, 6586)	Novel Protein sim. GBank gi|4506537|ref|NP_003812.1|pRIP2 -	Contains protein domain	kinase	1035
		UNKNOWN	(PF00069) - Eukaryotic protein
			kinase domain
408	29221338 (6491, 6492)	Novel Protein sim. GBank gi|4512667|gb|AAD21721.1| - (AC006931)	Contains protein domain	kinase	1027
		putative MAP kinase [Arabidopsis thaliana]	(PF00069) - Eukaryotic protein
			kinase domain
409	25258544 (2657, 2658)	Novel Protein sim. GBank gi|4539601|emb|CAB40012.1| - (AL049522)	Contains protein domain	kinase	1006
		serine/threonine-protein kinase [Schizosaccharomyces pombe]	(PF00069) - Eukaryotic protein
			kinase domain
410	30661640 (867, 868)	Novel Protein sim. GBank gi|465483|sp|P33886|WIS1_SCHPO -	Contains protein domain	kinase	1020
		PROTEIN KINASE WIS1	(PF00069) - Eukaryotic protein
			kinase domain
411	78960407 (4385, 4386)	Novel Protein sim. GBank gi|547785|sp|P36003|KKR1_YEAST -	Contains protein domain	kinase	1002
		PROBABLE SERINE/THREONINE-PROTEIN KINASE YKL171W	(PF00069) - Eukaryotic protein
			kinase domain
412	29685105 (349, 350)	Novel Protein sim. GBank gi|585793|sp|P38622|RCK1_YEAST -	Contains protein domain	kinase	1007
		SERINE/THREONINE-PROTEIN KINASE RCK1	(PF00069) - Eukaryotic protein
			kinase domain
413	87454473 (375, 376)	Novel Protein sim. GBank gi|3935168 (AC004557) - F17L21.11	Contains protein domain	kinase	1023
		[Arabidopsis thaliana]	(PF00072) - Response regulator
			receiver domain
414	80470074 (7573, 7574)	Novel Protein sim. GBank gi|4468682|emb|CAB38136.1| - (AL035591)	Contains protein domain	kinase	1003, 1004, 1008, 1010,
		phosphoglycerate kinase [Streptomyces coelicolor]	(PF00162) - Phosphoglycerate		1022, 1031
			kinases
415	77901754 (123, 124)	Novel Protein sim. GBank gi|2661698|emb|CAA15802| - (AL009204)	Contains protein domain	kinase	1008, 1037
		putative thimidine kinase [Streptomyces coelicolor]	(PF00265) - Thymidine kinases
416	16394057 (5823, 5824)	Novel Protein sim. GBank gi|125390|sp|P07128|KHSE_BRELA -	Contains protein domain	kinase	1021
		HOMOSERINE KINASE (HK)	(PF00288) - GHMP kinases
			putative ATP-binding proteins
417	39537520 (293, 294)	Novel Protein sim. GBank gi|1073282|pir||C55215 - 2-dehydro-3-	Contains protein domain	kinase	1006
		deoxygluconokinase (EC 2.7.1.45) - Erwinla chrysanthemi	(PF00294) - pfkB family
			carbohydrate kinase
418	36738408 (7691, 7692)	Novel Protein sim. GBank gi|2127192|pir||40463 - ribokinase (EC	Contains protein domain	kinase	1031
		2.7.1.15) - Bacillus subtilis	(PF00294) - pfkB family
			carbohydrate kinase
419	71088701 (6033, 6034)		Contains protein domain	kinase	1050
			(PF00294) - pfkB family
			carbohydrate kinase
420	80218550 (6387, 6388)	Novel Protein sim. GBank gi|548341|sp|P36010|NDK_YEAST -	Contains protein domain	kinase	1002, 1004, 1006, 1007,
		NUCLEOSIDE DIPHOSPHATE KINASE (NDK) (NDP KINASE)	(PF00334) - Nucleoside		1015, 1020, 1024
			diphosphate kinases
421	25260297(6719, 6720)	Novel Protein sim. GBank gi|171735 (M11181) - hexokinase P-II peptide	Contains protein domain	kinase	1006
		[Saccharomyces cerevisiae]	(PF00349) - Hexokinase
422	29445916 (6313, 6314)	Novel Protein sim. GBank gi|125121|sp|P16861|K6P1_YEAST - 6-	Contains protein domain	kinase	1020
		PHOSPHOFRUCTOKINASE ALPHA SUBUNIT	(PF00365) - Phosphofructokinase
		(PHOSPHOFRUCTOKINASE 1) (PHOSPHOHEXOKINASE) (6PF-1-K
		ALPHA SUBUNIT)
423	80248665 (1687, 1688)	Novel Protein sim. GBank gi|3122305|sp|Q27778|K6PF_SCHMA - 6-	Contains protein domain	kinase	1004, 1020, 1023
		PHOSPHOFRUCTOKINASE (PHOSPHOFRUCTOKINASE)	(PF00365) - Phosphofructokinase
		(PHOSPHOHEXOKINASE)
424	25259137 (7451, 7452)	Novel Protein sim. GBank gi|3122594|sp|Q59126|PFP_AMYME -	Contains protein domain	kinase	1021
		PYROPHOSPHATE-FRUCTOSE 6-PHOSPHATE 1-	(PF00365) - Phosphofructokinase
		PHOSPHOTRANSFERASE (6-PHOSPHOFRUCTOKINASE
		(PYROPHOSPHATE)) (PYROPHOSPHATE-DEPENDENT 6-
		PHOSPHOFRUCTOSE-1-KINASE) (PPI-PFK)
425	82060206 (6711, 6712)	Novel Protein sim. GBank gi|2960120|emb|CAA18018.1| - (AL022121)	Contains protein domain	kinase	1001, 1003, 1004, 1007,
		glpK [Mycobacterium tuberculosis]	(PF00370) - FGGY family of		1008, 1010, 1014, 1020,
			carbohydrate kinases		1021, 1022, 1024, 1025,
					1035
426	80249154 (7825, 7826)	Novel Protein sim. GBank gi|3122139|sp|Q63060|GLPK_RAT -	Contains protein domain	kinase	1004
		GLYCEROL KINASE (ATP: GLYCEROL 3-PHOSPHOTRANSFERASE)	(PF00370) - FGGY family of
		(GLYCEROKINASE) (GK) (ATP-STIMULATED GLUCOCORTICOID-	carbohydrate kinases
		RECEPTOR TRANSLOCATON PROMOTER) (ASTP)
427	80055278 (653, 654)	Novel Protein sim. GBank gi|3358091|dbj|BAA31995| - (AB015974)	Contains protein domain	kinase	1020, 1022
		glycerol kinase [Pseudomonas tolaasil]	(PF00370) - FGGY family of
			carbohydrate kinases
428	80047548 (7383, 7384)	Novel Protein sim. GBank gi|4204896 (U57100) - erythritol kinase	Contains protein domain	kinase	1003, 1015
		[Brucella abortus]	(PF00370) - FGGY family of
			carbohydrate kinases
429	78769251 (7003, 7004)	Novel Protein sim. GBank gi|4980782|gb|AAD35372.1|AE00171 -	Contains protein domain	kinase	1015
		(AE001710) sugar kinase, FGGY family [Thermotoga maritima]	(PF00370) - FGGY family of
			carbohydrate kinases
430	79611230 (4121, 4122)	Novel Protein sim. GBank gi|1077378|pir||S51445 - probable membrane	Contains protein domain	kinase	1004
		protein YLR222c - yeast (Saccharomyces cerevisiae)	(PF00400) - WD domain, G-beta
			repeat
431	80081455 (7721, 7722)	Novel Protein sim. GBank gi|2497146|sp|Q04305|YMY3_YEAST -	Contains protein domain	kinase	1003, 1020
		HYPOTHETICAL 57.7 KD PROTEIN IN AIP1-CTF13 INTERGENIC	(PF00400) - WD domain, G-beta
		REGION	repeat
432	56010654 (8637, 8638)	Novel Protein sim. GBank gi|1170646|sp|P43565|RI15_YEAST -	Contains protein domain	kinase	1041
		SERINE/THREONINE-PROTEIN KINASE RIM15	(PF00433) - Protein kinase C
			terminal domain
433	25246073 (7699, 7700)	Novel Protein sim. GBank gi|5031439|gb|AAD38172.1|AF15259 -	Contains protein domain	kinase	1041
		(AF152598) TadA [Actinobacillus actinomycetemcomitans]	(PF00437) - Bacterial type II
			secretion system protein
434	85533226 (7263, 7264)	Novel Protein sim. GBank gi|4982035|gb|AAD36537.1|AE00179 -	Contains protein domain	kinase	1024, 1046
		(AE001798) glucokinase [Thermotoga maritima]	(PF00480) - ROK family
435	94845347 (7933, 7934)	Novel Protein sim. GBank gi|4455704|emb|CAB36689| - (AL035500)	Contains protein domain	kinase	1024, 1027, 1041, 1046
		putative two-component system sensor [Mycobacterium leprae]	(PF00512) - Histidine kinase
436	78796199 (4913, 4914)	Novel Protein sim. GBank gi|1077386|pir||S51348 - hypothetical protein		kinase	1024
		YLR345w - yeast (Saccharomyces cerevisiae)
437	11072203 (5567, 5568)	Novel Protein sim. GBank gi|113559|sp|P10869|AK_YEAST -		kinase	1031
		ASPARTOKINASE (ASPARTATE KINASE)
438	80219067 (7127, 7128)	Novel Protein sim. GBank gi|1169289|sp|P43550|DHAK_YEAST -		kinase	1003, 1004, 1015, 1022
		DIHYDROXYACETONE KINASE 2 (GLYCERONE KINASE)
439	10174239 (2089, 2090)	Novel Protein sim. GBank gi|1176152|sp|P44507|YHAD_HAEIN -		kinase	1003
		HYPOTHETICAL PROTEIN HI0091
440	85811009 (5659, 5660)	Novel Protein sim. GBank gi|140977|sp|P18961|YPK2_YEAST -		kinase	1017
		SERINE/THREONINE-PROTEIN KINASE YPK2/YKR2
441	9061533 (3861, 3862)	Novel Protein sim. GBank gi|146923 (M24910) - nitrogenase reductase		kinase	1004
		[Escherichia coli]
442	15023387 (5237, 5238)	Novel Protein sim. GBank gi|1480174 (U56773) - pelle-like protein kinase		kinase	1001, 1022
		[Mus musculus]
443	47660080 (4719, 4720)	Novel Protein sim. GBank gi|1651932|dbj|BAA16858| - (D90901) nitrogen		kinase	1026
		fixation positive activator protein [Synechocystis sp.]
444	88095282 (6513, 6514)	Novel Protein sim. GBank gi|1652968|dbj|BAA17885| - (D90910) sensory		kinase	1031
		transduction histidine kinase [Synechocystis sp.]
445	79570150 (3697, 3698)	Novel Protein sim. GBank gi|1653309|dbj|BAA18224| - (D90912)		kinase	1015
		regulatory components of sensory transduction system [Synechocystis
		sp.]
446	79565494 (5593, 5594)	Novel Protein sim. GBank gi|1709963|sp|Q10791|PYRH_MYCTU -		kinase	1015
		URIDYLATE KINASE (UK) (URIDINE MONOPHOSPHATE KINASE)
		(UMP KINASE)
447	37802513 (1095, 1096)	Novel Protein sim. GBank gi|1711416|sp|P53351|SNK_MOUSE -		kinase	1055
		SERINE/THREONINE-PROTEIN KINASE SNK (SERUM INDUCIBLE
		KINASE)
448	87452635 (6847, 6848)	Novel Protein sim. GBank gi|172986 (K02116) - thymidylate kinase		kinase	1020, 1023
		[Saccharomyces cerevisiae]
449	80234034 (3939, 3940)	Novel Protein sim. GBank gi|1730060|sp|P53894|KNQ1_YEAST -		kinase	1001, 1003, 1004, 1006,
		PROBABLE SERINE/THREONINE-PROTEIN KINASE YNL161W			1008, 1020, 1021, 1022,
					1023, 1036
450	25322315 (6143, 6144)	Novel Protein sim. GBank gi|173179 (M59835) - protein kinase		kinase	1015
		[Saccharomyces cerevisiae]
451	20728597 (2219, 2220)	Novel Protein sim. GBank gi|1839006|emb|CAB06648| - (Z85982) argB		kinase	1004, 1010
		[Mycobacterium tuberculosis]
452	8219595 (693, 694)	Novel Protein sim. GBank gi|231831|sp|P29931|COBP_PSEDE -		kinase	1020
		COBINAMIDE KINASE/COBINAMIDE PHOSPHATE
		GUANYLYLTRANSFERASE
453	23333334 (6951, 6952)	Novel Protein sim. GBank gi|2499489|sp|Q41141|PFPB_RICCO -		kinase	1050
		PYROPHOSPHATE-FRUCTOSE 6-PHOSPHATE 1-
		PHOSPHOTRANSFERASE BETA SUBUNIT (PFP) (6-
		PHOSPHOFRUCTOKINASE (PYROPHOSPHATE)) (PYROPHOSPHATE-
		DEPENDENT 6-PHOSPHOFRUCTOSE-1-KINASE) (PPI-PFK)
454	66051893 (7349, 7350)	Novel Protein sim. GBank gi|2499558|sp|Q55168|Y473_SYNY3-		kinase	1007, 1046
		HYPOTHETICAL 84.2 KD PROTEIN SLR0473
455	27368121 (6569, 6570)	Novel Protein sim. GBank gi|2499624|sp|Q08217|KOE5_YEAST -		kinase	1007
		PROBABLE SERINE/THREONINE-PROTEIN KINASE YOL045W
456	21413329 (5531, 5532)	Novel Protein sim. GBank gi|2624308|emb|CAA15581| - (AL008967) ribF		kinase	1003
		[Mycobacterium tuberculosis]
457	66770442 (2755, 2756)	Novel Protein sim. GBank gi|2665722 (AF035608) - ATP sulfurylase GTP-		kinase	1046
		binding subunit/ApS kinase [Pseudomonas aeruginosa]
458	32118574 (5557, 5558)	Novel Protein sim. GBank gi|281611|pir||B41863 - two-component		kinase	1004
		regulatory protein lemA - Pseudomonas syringae
459	25261297 (8675, 8676)	Novel Protein sim. GBank gi|2853031|gb|AAC02225.1| - (AF045252)		kinase	1002, 1020
		tousled-like kinase [Mus musculus]
460	78395482 (2427, 2428)	Novel Protein sim. GBank gi|3002527 (AF010144) - neuronal thread		kinase	1027
		protein AD7c-NTP [Homo sapiens]
461	78676108 (627, 628)	Novel Protein sim. GBank gi|3192019|emb|CAA19418| - (AL023797)		kinase	1006, 1024
		uridylate kinase [Streptomyces coelicolor]
462	65678114 (8507, 8508)	Novel Protein sim. GBank gi|3417448|dbj|BAA32344.1| - (AB010087)		kinase	1008
		UMP kinase [Pseudomonas aeruginosa]
463	79562897 (7993, 7994)	Novel Protein sim. GBank gi|3721570|dbj|BAA33549| - (AB012767) CheA		kinase	1001
		Pseudomonas aeruginosa]
464	57300008 (5529, 5530)	Novel Protein sim. GBank gi|3876090|emb|CAA93459.1| - (Z69635)		kinase	1003
		Similarity to Yeast uridine kinase (SW: URK1_YEAST); cDNA EST
		EMBL: Z14695 comes from this gene; cDNA EST CEMSE17F comes from
		this gene; cDNA EST EMBL: D67355 comes from this gene; cDNA EST
		yk209h1.5 comes from this gen . . .
465	23308597 (1307, 1308)	Novel Protein sim. GBank gi|4263521|gb|AAD15347| - (AC004044)		kinase	1050
		putative WD-repeat protein [Arabidopsis thaliana]
466	79569260 (8601, 8602)	Novel Protein sim. GBank gi|4417286|gb|AAD20411| - (AC007019)		kinase	1031
		putative shikimate kinase [Arabidopsis thaliana]
467	55286491 (4309, 4310)	Novel Protein sim. GBank gi|4464269|emb|CAB37472| - (AL035559)		kinase	1026, 1050
		probable riboflavin kinase (FAD synthetase) [Streptomyces coelicolor]
468	11103781 (403, 404)	Novel Protein sim. GBank gi|462451|sp|P34244|KKK1_YEAST -		kinase	1004
		PROBABLE SERINE/THREONINE-PROTEIN KINASE YKL101W
469	8343449 (6465, 6466)	Novel Protein sim. GBank gi|464393|sp|P33639|PILS_PSEAE - SENSOR		kinase	1008
		PROTEIN PILS
470	66441099 (661, 662)	Novel Protein sim. GBank gi|464401|sp|P33973|PKN1_MYXXA -		kinase	1020
		SERINE/THREONINE-PROTEIN KINASE PKN1
471	80219209 (2449, 2450)	Novel Protein sim. GBank gi|464800|sp|P34164|SIP2_YEAST - SIP2		kinase	1008, 1020
		PROTEIN (SPM2 PROTEIN)
472	79822217 (4453, 4454)	Novel Protein sim. GBank gi|4768862|gb|AAD29656.1|AF12475 -		kinase	1031
		(AF124757) uridylate kinase [Zymomonas mobilis]
473	11130500 (2149, 2150)	Novel Protein sim. GBank gi|4980976|gb|AAD35552.1|AE00172 -		kinase	1004
		(AE001724) response regulator [Thermotoga maritima]
474	30239675 (1713, 1714)	Novel Protein sim. GBank gi|5019771|gb|AAD37857.1|AF13326 -		kinase	1041
		(AF133263) histidine protein kinase-response regulator hybrid protein
		CvgSY [Pseudomonas syringae pv. syringae]
475	9906368 (7487, 7488)	Novel Protein sim. GBank gi|5458972|emb|CAB50458.1| - (AJ248288)		kinase	1002
		PAB1332 [Pyrococcus abyssi]
476	25139201 (8207, 8208)	Novel Protein sim. GBank gi|5702015|emb|CAB52141.1| - (AJ012215)		kinase	1002
		GAL83 protein [Solanum tuberosum]
477	17958199 (8639, 8640)	Novel Protein sim. GBank gi|585348|sp|P38080|KBQ9_YEAST -		kinase	1015, 1041
		PROBABLE SERINE/THREONINE-PROTEIN KINASE YBR059C
478	19513267 (6921, 6922)	Novel Protein sim. GBank gi|629283|pir||S48579 - hypothetical protein -		kinase	1021
		Mycoplasma capricolum (SGC3) (fragment)
479	77655106 (1987, 1988)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		kinase	1050
		SUBFAMILY J WARNING ENTRY !!!!
480	78090999 (8789, 8790)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		kinase	1034
		SUBFAMILY J WARNING ENTRY !!!!
481	55309229 (8945, 8946)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		kinase	1017
		SUBFAMILY J WARNING ENTRY !!!!
482	29682073 (7539, 7540)	Novel Protein sim. GBank gi|729900|sp|Q01919|KIN4_YEAST -		kinase	1007
		SERINE/THREONINE-PROTEIN KINASE KIN4
483	30259891 (6619, 6620)	Novel Protein sim. GBank gi|730745|sp|P39928|SLN1_YEAST -		kinase	1006
		OSMOLARITY TWO-COMPONENT SYSTEM PROTEIN SLN1
484	32290853 (2671, 2672)	Novel Protein sim. GBank gi|76183|pir||QQECIL - hypothetical 35K protein		kinase	1000, 1003, 1008, 1010
		(ileS-Isp operon) - Escherichia coli
485	65481433 (5521, 5522)	Novel Protein sim. GBank gi|953191|emb|CAA62365| - (X90856)		kinase	1046
		aminoglycoside phosphotransferase (3′)IIps [Pseudomonas aeruginosa]
486	29462591 (3841, 3842)	Novel Protein sim. GBank gi|1345587|sp|P49106|1431_MAIZE - 14-3-3-	Contains protein domain	kinaseinhibitor	1024
		LIKE PROTEIN GF14-6	(PF00244) - 14-3-3 proteins
487	80432144 (6789, 6790)	Novel Protein sim. GBank gi|1724020|sp|P49774|YHIT_MYCLE -		kinaseinhibitor	1035
		HYPOTHETICAL HIT-LIKE PROTEIN U296A
488	29492267 (2929, 2930)	Novel Protein sim. GBank gi|1176807|sp|Q09564|YR71_CAEEL -	Contains protein domain	kinasereceptor	1035
		HYPOTHETICAL 118.2 KD PROTEIN F43C1.1 IN CHROMOSOME III	(PF00560) - Leucine Rich Repeat
489	78362875 (4495, 4496)	Novel Protein sim. GBank gi|101398|pir||B28097 - TyB protein - yeast		kinasereceptor	1006
		(Saccharomyces cerevisiae) transposon Ty1-H3
490	20295815 (8007, 8008)	Novel Protein sim. GBank gi|4758676|ref|NP_004181.1|pLIPF - lipase,		lipase	1020
		gastric
491	25267855 (4647, 4648)	Novel Protein sim. GBank gi|1022734 (U36277) - I-kappa B alpha chain	Contains protein domain	MHC	1021
		[Mus musculus]	(PF00023) - Ank repeat
492	13889767 (8155, 8156)			MHC	1031
493	41090826 (8385, 8386)	Novel Protein sim. GBank gi|4539520|emb|CAB39994.1| - (AL035424)	Contains protein domain	nucl_recpt	1034
		dA22D12.1 (novel protein similar to Drosophila Kelch (Ring Canal protein,	(PF00651) - BTB/POZ domain
		KEL) and a heterogenous set of other types of proteins) [Homo sapiens]
494	13075804 (6425, 6426)	Novel Protein sim. GBank gi|2529416 (U73935) - unknown [Shewanella		nucl_recpt	1022
		sp. SCRC-2738]
495	40379402 (7751, 7752)	Novel Protein sim. GBank gi|3036883|emb|CAA18516| - (AL022374)		nucl_recpt	1034
		putative ABC transporter [Streptomyces coelicolor]
496	87453786 (4771, 4772)	Novel Protein sim. GBank gi|5360230|dbj|BAA81911.1| - (AB015287) Ran		nucl_recpt	1002, 1006, 1015, 1023
		[Oryza sativa]
497	13872373 (6931, 6932)	Novel Protein sim. GBank gi|5453555|ref|NP_006316.1|pARA2 - RAN,		nucl_recpt	1031
		member RAS oncogene family
498	27957653 (7881, 7882)	Novel Protein sim. GBank gi|4050093 (AF110520) - NG28 [Mus	Contains protein domain	nuclease	1003, 1022
		musculus]	(PF00023) - Ank repeat
499	85800159 (5591, 5592)	Novel Protein sim. GBank gi|2500086|sp|Q59560|RECA_MYCSM - RECA	Contains protein domain	nuclease	1007, 1014, 1023
		PROTEIN	(PF00154) - recA bacterium DNA
			recombination proteins
500	78676017 (4051, 4052)	Novel Protein sim. GBank gi|1171033|sp|P43247|MSH2_MOUSE - DNA	Contains protein domain	nuclease	1006
		MISMATCH REPAIR PROTEIN MSH2	(PF00488) - DNA mismatch repair
			proteins, mutS family
501	35900336 (1943, 1944)	Novel Protein sim. GBank gi|79102|pir||A28668 - DNA mismatch repair	Contains protein domain	nuclease	1050
		protein mutS - Salmonella typhimurium	(PF00488) - DNA mismatch repair
			proteins, mutS family
502	79648614 (5663, 5664)	Novel Protein sim. GBank gi|887620|emb|CAA90210| - (Z49939) unknown	Contains protein domain	nuclease	1002, 1021, 1035
		[Saccharomyces cerevislae]	(PF00636) - RNase3 domain
503	79818359 (4553, 4554)	Novel Protein sim. GBank gi|140964|sp|P26793|RA27_YEAST -	Contains protein domain	nuclease	1004
		STRUCTURE SPECIFIC ENDONUCLEASE RAD27	(PF00752) - XPG N-terminal
			domain
504	66258516 (1831, 1832)	Novel Protein sim. GBank gi|1710612|sp|Q10793|RNH2_MYCTU -	Contains protein domain	nuclease	1008, 1015
		PROBABLE RIBONUCLEASE HII (RNASE HII)	(PF01351) - Ribonuclease HII
505	28962172 (7273, 7274)	Novel Protein sim. GBank gi|134579|sp|P24554|RADA_ECOLI - DNA	Contains protein domain	nuclease	1002
		REPAIR PROTEIN RADA (DNA REPAIR PROTEIN SMS)	(PF01443) - Viral (Superfamily 1)
			RNA helicase
506	78317604 (1805, 1806)	Novel Protein sim. GBank gi|106322|pir||B34087 - hypothetical protein		nuclease	1024
		(L1H 3′ region) - human
507	79113849 (2893, 2894)	Novel Protein sim. GBank gi|106322|pir||B34087 - hypothetical protein		nuclease	1006
		(L1H 3′ region) - human
508	11814919 (1113, 1114)	Novel Protein sim. GBank gi|111811|pir||S16788 - probable reverse		nuclease	1022
		transcriptase - rat
509	10340226 (1591, 1592)	Novel Protein sim. GBank gi|1174917|sp|P44410|UVRA_HAEIN -		nuclease	1002
		EXCINUCLEASE ABC SUBUNIT A
510	79959371 (8569, 8570)	Novel Protein sim. GBank gi|1176326|sp|PP44608|RBN_HAEIN -		nuclease	1014
		RIBONUCLEASE BN (RNASE BN)
511	57284222 (6893, 6894)	Novel Protein sim. GBank gi|118921|sp|P21704|DRN1_RAT -		nuclease	1003, 1004, 1008, 1020,
		DEOXYRIBONUCLEASE I PRECURSOR (DNASE I)			1022, 1031
512	12797175 (1623, 1624)	Novel Protein sim. GBank gi|119669|sp|P07648|EX5C_ECOLI -		nuclease	1003
		EXODEOXYRIBONUCLEASE V 125 KD POLYPEPTIDE
		(EXONUCLEASE V GAMMA CHAIN)
513	29896989 (105, 106)	Novel Protein sim. GBank gi|126295|sp|P08547|LIN1_HUMAN - LINE-1		nuclease	1022
		REVERSE TRANSCRIPTASE HOMOLOG
514	95087970 (1815, 1816)	Novel Protein sim. GBank gi|126295|sp|P08547|LIN1_HUMAN - LINE-1		nuclease	1041
		REVERSE TRANSCRIPTASE HOMOLOG
515	33207232 (441, 442)	Novel Protein sim. GBank gi|126296|sp|P08548|LIN1_NYCCO - LINE-1		nuclease	1024
		REVERSE TRANSCRIPTASE HOMOLOG
516	86471727 (761, 762)	Novel Protein sim. GBank gi|126296|sp|P08548|LIN1_NYCCO - LINE-1		nuclease	1026
		REVERSE TRANSCRIPTASE HOMOLOG
517	79634315 (2057, 2058)	Novel Protein sim. GBank gi|126296|sp|P08548|LIN1_NYCCO - LINE-1		nuclease	1023
		REVERSE TRANSCRIPTASE HOMOLOG
518	56155730 (7725, 7726)	Novel Protein sim. GBank gi|126296|sp|P08548|LIN1_NYCCO - LINE-1		nuclease	1019
		REVERSE TRANSCRIPTASE HOMOLOG
519	46873742 (7985, 7986)	Novel Protein sim. GBank gi|1335205|emb|CAA36480| - (X52235) ORFII		nuclease	1026
		[Homo sapiens]
520	11818060 (1117, 1118)	Novel Protein sim. GBank gi|1553037 (U68235) - RecN [Bacillus subtilis]		nuclease	1004
521	66727335 (5549, 5550)	Novel Protein sim. GBank gi|1890658 (U70046) - UV endonuclease		nuclease	1046
		[Pseudomonas aeruginosa]
522	36902869 (8153, 8154)	Novel Protein sim. GBank gi|2072951 (U93564) - putative p150 [Homo		nuclease	1024
		sapiens]
523	58090567 (7577, 7578)	Novel Protein sim. GBank gi|2072964 (U93569) - putative p150 [Homo		nuclease	1051
		sapiens]
524	88098361 (8017, 8018)	Novel Protein sim. GBank gi|2072967 (U93570) - putative p150 [Homo		nuclease	1017
		sapiens]
525	94853626 (1931, 1932)	Novel Protein sim. GBank gi|2193870|dbj|BAA20419| - (D84391) reverse		nuclease	1008
		transcriptase [Mus musculus]
526	21433107 (2223, 2224)	Novel Protein sim. GBank gi|2443320|dbj|BAA22288| - (D85597)		nuclease	1008
		polyprotein [Oryza australiensis]
527	11588373 (7217, 7218)	Novel Protein sim. GBank gi|2979589 (AC004416) -		nuclease	1031
		WUGSC: H_RG013N12.gw.1335199.a gene product [Homo sapiens]
528	35003877 (5019, 5020)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		nuclease	1047
		ORF2 [Canis familiaris]
529	9845639 (5731, 5732)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		nuclease	1002
		ORF2 [Canis familiaris]
530	35100184 (7789, 7790)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		nuclease	1022
		ORF2 [Canis familiaris]
531	20728368 (1567, 1568)	Novel Protein sim. GBank gi|3329275 (AE001353) - Axial Filament Protein		nuclease	1004
		[Chlamydia trachomatis]
532	95001722 (7419, 7420)	Novel Protein sim. GBank gi|417577|sp|P32863|RA54_YEAST - DNA		nuclease	1015, 1020, 1022, 1035
		REPAIR AND RECOMBINATION PROTEIN RAD54
533	70945419 (5279, 5280)	Novel Protein sim. GBank gi|4468694|emb|CAB38148.1| - (AL035591)		nuclease	1026
		ABC excision nuclease subunit A [Streptomyces coelicolor]
534	79756492 (3559, 3560)	Novel Protein sim. GBank gi|4585583|emb|CAB40851.1| - (AL049628)		nuclease	1020
		putative DNA repair protein [Streptomyces coelicolor]
535	71793553 (3885, 3886)	Novel Protein sim. GBank gi|465488|sp|P33301|XRS2_YEAST - DNA		nuclease	1007
		REPAIR PROTEIN XRS2
536	71059951 (2151, 2152)	Novel Protein sim. GBank gi|465736|sp|P34280|YKK3_CAEEL -		nuclease	1030
		HYPOTHETICAL 64.3 KD GTP-BINDING PROTEIN C02F5.3 IN
		CHROMOSOME III
537	24116094 (3991, 3992)	Novel Protein sim. GBank gi|5031889|ref|NP_005570.1|pLRE1 - LINE		nuclease	1002
		retrotransposable element 1
538	78269359 (6701, 6702)	Novel Protein sim. GBank gi|5031889|ref|NP_005570.1|pLRE1 - LINE		nuclease	1026
		retrotransposable element 1
539	79620600 (4693, 4694)	Novel Protein sim. GBank gi|536873 (M34549) - POL3 gene product		nuclease	1023
		[Saccharomyces cerevisiae]
540	78385400 (5471, 5472)	Novel Protein sim. GBank gi|5678922|gb|AAD46808.1|AF15764 -		nuclease	1024
		(AF157643) RecB [Mycobacterium smegmatis]
541	80218357 (17, 18)	Novel Protein sim. GBank gi|731301|sp|P39707|SE34_YEAST - TRNA-		nuclease	1002, 1004, 1006, 1008,
		SPLICING ENDONUCLEASE SUBUNIT SEN34 (TRNA-INTRON			1010, 1015, 1020, 1021,
		ENDONUCLEASE)			1022, 1028, 1031, 1035
542	78739907 (257, 258)	Novel Protein sim. GBank gi|807677 (M13101) - unknown protein [Rattus		nuclease	1024
		norvegicus]
543	79654125 (6053, 6054)	Novel Protein sim. GBank gi|87765|pir||JU0033 - hypothetical L1 protein		nuclease	1050
		(third Intron of gene TS) - human
544	86476034 (8003, 8004)	Novel Protein sim. GBank gi|87765|pir||JU0033 - hypothetical L1 protein		nuclease	1026
		(third Intron of gene TS) - human
545	71770950 (2443, 2444)			nuclease	1024
546	46905681 (4497, 4498)			nuclease	1037
547	79113846 (2735, 2736)	Novel Protein sim. GBank gi|2132474|pir||S58091 - probable membrane		nucleaseinhib	1021, 1036
		protein YDR091c - yeast (Saccharomyces cerevisiae)
548	79211727 (8029, 8030)	Novel Protein sim. GBank gi|499686 (L33861) - fibropellin Ia [Heliocidaris	Contains protein domain	oncogene	1051
		erythrogramma]	(PF00008) - EGF-like domain
549	25266562 (2359, 2360)	Novel Protein sim. GBank gi|5650780|gb|AAD45948.1|AF15196 -	Contains protein domain	oncogene	1006
		(AF151968) RGS protein RGS-17 [Gallus gallus]	(PF00615) - Regulator of G
			protein signaling domain
550	79800908 (8519, 8520)	Novel Protein sim. GBank gi|135914|sp|P17408|TLM_MOUSE - TLM		oncogene	1001, 1002, 1006, 1015,
		PROTEIN (TLM ONCOGENE)			1020, 1022, 1024, 1025,
					1031, 1035, 1041, 1051
551	27846133 (7651, 7652)	Novel Protein sim. GBank gi|2137470|pir||49342 - Ifc - mouse		oncogene	1004
552	14995192 (3049, 3050)	Novel Protein sim. GBank gi|2462824 (AF000657) - similar to Jun		oncogene	1022
		activation domain binding protein [Arabidopsis thaliana]
553	49524780 (1273, 1274)	Novel Protein sim. GBank gi|2516239|dbj|BAA22654| - (AB004664)		oncogene	1022, 1033, 1055
		Rab33B [Mus musculus]
554	29689163 (4623, 4624)	Novel Protein sim. GBank gi|313261|emb|CAA51936| - (X73532) TEF1		oncogene	1007
		[Saccharomyces cerevisiae]
555	25255728 (1573, 1574)	Novel Protein sim. GBank gi|4586338|dbj|BAA76357.1| - (AB016787)	Contains protein domain	oxidase	1002
		cytochrome o ubiquinol oxidase B [Pseudomonas putida]	(PF00115) - Cytochrome C and
			Quinol oxidase polypeptide I
556	80232185 (2119, 2120)	Novel Protein sim. GBank gi|117135|sp|P21592|COXX_YEAST -		oxidase	1015, 1020, 1022
		CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX10
		PRECURSOR
557	94631702 (4875, 4876)	Novel Protein sim. GBank gi|1176480|sp|P44453|YJJT_HAEIN -		oxidase	1002, 1028
		HYPOTHETICAL PROTEIN HI0012
558	78949661 (4455, 4456)	Novel Protein sim. GBank gi|129736|sp|P28225|PDXH_ECOLI -		oxidase	1021
		PYRIDOXAMINE 5′-PHOSPHATE OXIDASE (PNP/PMP OXIDASE)
559	90936753 (197, 198)	Novel Protein sim. GBank gi|3024323|sp|O35078|OXDA_RAT - D-AMINO		oxidase	1018
		ACID OXIDASE (DAMOX) (DAO) (DAAO)
560	78368526 (7411, 7412)	Novel Protein sim. GBank gi|3402239|emb|CAA20175| - (AL031184)		oxidase	1002, 1026
		aminomethyltransferase [Streptomyces coelicolor]
561	79618286 (5795, 5796)	Novel Protein sim. GBank gi|520754 (L27797) - putative [Bacillus subtilis]		oxidase	1003
562	27980141 (2865, 2866)	Novel Protein sim. GBank gi|547994|sp|P37061|NAOX_ENTFA - NADH		oxidase	1004
		OXIDASE (NOXASE)
563	20414038 (8695, 8696)	Novel Protein sim. GBank gi|5578703|gb|AAD17377.2| - (U65001)	Contains protein domain	oxygenase	1008
		putative aromatic-ring hydroxylating dioxygenase alpha-subunit	(PF00355) - Rieske [2Fe-2S]
		[Sphingomonas sp.]	domain
564	10200183 (1625, 1626)	Novel Protein sim. GBank gi|3043760|dbj|BAA25544| - (AB012759) rPOP	Contains protein domain	peptidase	1004
		[Rattus norvegicus]	(PF00326) - Prolyl oligopeptidase
			family
565	78680263 (6917, 6918)	Novel Protein sim. GBank gi|1651216|dbj|BAA13561.1| - (D88209) Pz-		peptidase	1002
		peptidase [Bacillus IIchenlformis]
566	80079434 (1155, 1156)	Novel Protein sim. GBank gi|2415396 (AF015775) - carboxypeptidase		peptidase	1031
		[Bacillus subtilis]
567	79853412 (107, 108)	Novel Protein sim. GBank gi|2688962 (AF027768) - LspA [Serratia		peptidase	1002, 1004
		marcescens]
568	86477781 (7743, 7744)	Novel Protein sim. GBank gi|2911008|emb|CAA17501| - (AL021958) map'		peptidase	1017
		[Mycobacterium tuberculosis]
569	28828156 (5349, 5350)	Novel Protein sim. GBank gi|461915|sp|P33894|DAP1_YEAST -		peptidase	1001, 1006, 1020
		DIPEPTIDYL AMINOPEPTIDASE A (DPAP A) (YSCIV)
570	88098768 (5321, 5322)	Novel Protein sim. GBank gi|477819|pir||B48529 - mitochondrial		peptidase	1005, 1020, 1023
		processing peptidase (EC 3.4.99.41) beta chain precursor - potato
571	14998912 (6635, 6636)	Novel Protein sim. GBank gi|5139244|gb|AAD40473.1|AF11653 -		peptidase	1022
		(AF116532) endopeptidase O [Streptococcus parasanguinis]
572	55926145 (1305, 1306)	Novel Protein sim. GBank gi|731481|sp|P40051|YEQ8_YEAST -		peptidase	1019, 1020, 1031
		HYPOTHETICAL 58.0 KD PEPTIDASE IN PTP3-ILV1 INTERGENIC
		REGION
573	20436220 (229, 230)	Novel Protein sim. GBank gi|1085007|pir||S49465 - catalase (EC 1.11.1.6) -	Contains protein domain	peroxidase	1022
		nematode (Onchocerca volvulus)	(PF00199) - Catalase
574	46693063 (6349, 6350)	Novel Protein sim. GBank gi|231692|sp|P29422|CATA_MICLU -	Contains protein domain	peroxidase	1031
		CATALASE	(PF00199) - Catalase
575	80384348 (6741, 6742)	Novel Protein sim. GBank gi|3608|emb|CAA28298| - (X04625) catalase T	Contains protein domain	peroxidase	1002, 1003, 1004, 1006,
		(AA 1-562) [Saccharomyces cerevisiae]	(PF00199) - Catalase		1007, 1008, 1015, 1020,
					1021, 1022, 1024, 1026,
					1028, 1031, 1035, 1036
					1041
576	79256928 (8821, 8822)	Novel Protein sim. GBank gi|2598550|emb|CAA03927| - (AJ000109)	Contains protein domain	peroxidase	1020, 1024, 1036, 1041
		gluthatione peroxidase [Lactococcus lactis]	(PF00255) - Glutathione
			peroxidases
577	78760632 (5285, 5286)	Novel Protein sim. GBank gi|464970|sp|P34760|TSA1_YEAST - THIOL-		peroxidase	1041
		SPECIFIC ANTIOXIDANT PROTEIN (PRP)
578	78736927 (6541, 6542)	Novel Protein sim. GBank gi|465521|sp|P34227|YBG4_YEAST -		peroxidase	1020
		HYPOTHETICAL 29.5 KD PROTEIN IN SEF1-KIP1 INTERGENIC
		REGION
579	86471554 (7799, 7800)	Novel Protein sim. GBank gi|1001298|dbj|BAA10785| - (D64006)	Contains protein domain	phosphatase	1017
		chemotaxis protein CheA [Synechocystis sp.]	(PF00072 - Response regulator
			receiver domain
580	94997571 (7845, 7846)	Novel Protein sim. GBank gi|2815358|emb|CAA16481| - (AL021530)	Contains protein domain	phosphatase	1004
		puative turgor pressure regulator [Streptomyces coelicolor]	(PF00072) - Response regulator
			receiver domain
581	95292942 (2279, 2280)	Novel Protein sim. GBank gi|2916942|emb|CAA17580| - (AL021999)	Contains protein domain	phosphatase	1003, 1010, 1014, 1020,
		hypothetical protein Rv0981 [Mycobacterium tuberculosis]	(PF00072) - Response regulator		1022, 1031, 1036
			receiver domain
582	11692257 (7489, 7490)	Novel Protein sim. GBank gi|1172700|sp|P43922|PT1_HAEIN -	Contains protein domain	phosphatase	1031
		PHOSPHOENOLPYRUVATE- PROTEIN PHOSPHOTRANSFERASE	(PF00391) - PEP-utilizing
		(PHOSPHOTRANSFERASE SYSTEM, ENZYME I)	enzymes
583	23308875 (2679, 2680)	Novel Protein sim. GBank gi|3281853|emb|CAA19748| - (AL031004)	Contains protein domain	phosphatase	1050
		putative protein [Arabidopsis thaliana]	(PF00481) - Protein phosphatase
			2C
584	79168027 (4989, 4990)	Novel Protein sim. GBank gi|499301|emb|CAA54383| - (X77116) ABI1	Contains protein domain	phosphatase	1028, 1047
		[Arabidopsis thaliana]	(PF00481) - Protein phosphatase
			2C
585	20293956 (5551, 5552)	Novel Protein sim. GBank gi|2960189|emb|CAA18087.1| - (AL022121)	Contains protein domain	phosphatase	1001
		hypothetical protein Rv3765c [Mycobacterium tuberculosis]	(PF00486) - Transcriptional
			regulatory protein, C terminal
586	36990550 (8281, 8282)	Novel Protein sim. GBank gi|509815 (U01971) - MtrA [Mycobacterium	Contains protein domain	phosphatase	1014
		tuberculosis]	(PF00486) - Transcriptional
			regulatory protein, C terminal
587	80241814 (3833, 3834)	Novel Protein sim. GBank gi|586390|sp|P38148|YB9T_YEAST -	Contains protein domain	phosphatase	1004, 1006, 1023
		PROBABLE PROTEIN-TYROSINE PHOSPHATASE YBR276C	(PF00782) - Dual specificity
			phosphatase, catalytic domain
588	87898935 (5933, 5934)	Novel Protein sim. GBank gi|3128356 (AF010496) - hypothetical protein		phosphatase	1013
		[Rhodobacter capsulatus]
589	29455367 (3715, 3716)	Novel Protein sim. GBank gi|4091129|gb|AAC98973| - (AF050165) protein		phosphatase	1024
		phosphatase 2A regulatory subunit PR59; PP2A regulatory subunit PR59
		[Mus musculus]
590	10868760 (5779, 5780)	Novel Protein sim. GBank gi|141240|sp|P23139|YPE2_RHORU -		phosphorylase	1031
		HYPOTHETICAL 25.8 KD PROTEIN IN PETC 3′REGION
591	79181916 (7997, 7998)	Novel Protein sim. GBank gi|118829|sp|P21189|DPO2_ECOLI - DNA	Contains protein domain	polymerase	1020
		POLYMERASE II (POL II)	(PF00136) - DNA polymerase
			family B
592	8364885 (779, 780)	Novel Protein sim. GBank gi|5002704|emb|CAB44358.1| - (AJ242630)	Contains protein domain	polymerase	1008
		DNA polymerase I [Methylobacterium sp. DM4]	(PF00476) - DNA polymerase
			family A
593	79639300 (3001, 3002)	Novel Protein sim. GBank gi|4982191|gb|AAD36686.1|AE00180 -	Contains protein domain	polymerase	1035
		(AE001805) DNA-directed DNA polymerase I [Thermotoga maritima]	(PF01367) - 5′-3′exonuclease
594	86474933 (3183, 3184)	Novel Protein sim. GBank gi|123452|sp|P28630|HOLA_ECOLI - DNA		polymerase	1035
		POLYMERASE III, DELTA SUBUNIT
595	79612944 (7821, 7822)	Novel Protein sim. GBank gi|171412 (M61710) - DNA polymerase II		polymerase	1004
		subunit-B [Saccharomyces cerevislae]
596	27845712 (809, 810)	Novel Protein sim. GBank gi|1723953|sp|P53091|MCM6_YEAST -		polymerase	1008
		MINICHROMOSOME MAINTENANCE PROTEIN 6
597	35112033 (1855, 1856)	Novel Protein sim. GBank gi|2506368|sp|P28631|HOLB_ECOLI - DNA		polymerase	1000
		POLYMERASE III, DELTA'SUBUNIT
598	79626110 (7599, 7600)	Novel Protein sim. GBank gi|2664208|emb|CAA10903| - (AJ222643)		polymerase	1008, 1036
		Glycyl-tRNA synthetase [Thermus thermophilus]
599	80237241 (413, 414)	Novel Protein sim. GBank gi|2960145|emb|CAA18043.1| - (AL022121)		polymerase	1001, 1008, 1020, 1022,
		dnaZX [Mycobacterium tuberculosis]			1025
600	20474435 (1219, 1220)	Novel Protein sim. GBank gi|4102990 (AF019254) - DNA polymerase		polymerase	1031
		epsilon homolog [Emericella nidulans]
601	33039786 (8615, 8616)	Novel Protein sim. GBank gi|4102990 (AF019254) - DNA polymerase		polymerase	1000
		epsilon homolog [Emericella nidulans]
602	20610414 (1915, 1916)	Novel Protein sim. GBank gi|585062|sp|Q07700|DPO1_MYCTU - DNA		polymerase	1003
		POLYMERASE I (POL I)
603	30407410 (5247, 5248)	Novel Protein sim. GBank gi|730382|sp|P10363|PRI1_YEAST - DNA		polymerase	1047
		PRIMASE SMALL SUBUNIT (DNA PRIMASE 48 KD SUBUNIT) (P48)
604	79835306 (1879,1880)	Novel Protein sim. GBank gi|730503|sp|P40339|RFC4_YEAST -		polymerase	1021
		ACTIVATOR 1.37 KD SUBUNIT (REPLICATION FACTOR C 37 KD
		SUBUNIT)
605	86660271 (2327, 2328)	Novel Protein sim. GBank gi|2104908|emb|CAA68912| - (Y07632)	Contains protein domain	potassium_channel	1041
		potassium channel [Zea mays]	(PF00023) - Ank repeat
606	34129572 (6721, 6722)	Novel Protein sim. GBank gi|4103749 (AF027166) - aspartic protease	Contains protein domain	protease	1024
		precursor [Strongyloides stercoralis]	(PF00026) - Eukaryotic aspartyl
			protease
607	94140127 (7575, 7576)	Novel Protein sim. GBank gi|4455705|emb|CAB36690| - (AL035500)	Contains protein domain	protease	1002
		putative serine protease [Mycobacterium leprae]	(PF00089) - Trypsin
608	27969651 (607, 608)	Novel Protein sim. GBank gi|4506153|ref|NP_002764.1|pPRSS -	Contains protein domain	protease	1031
		protease, serine, 8 (prostasin)	(PF00089) - Trypsin
609	78738795 (7611, 7612)	Novel Protein sim. GBank gi|91949|pir||S15904 - alpha-1 proteinase	Contains protein domain	protease	1020, 1024
		inhibitor III, variant 1 precursor - rat	(PF00207) - Alpha-2-
			macroglobulin family
610	79834611 (5999, 6000)	Novel Protein sim. GBank gi|130858|sp|P21243|PRCI_YEAST -	Contains protein domain	protease	1015, 1021
		PROTEASOME COMPONENT C7-ALPHA (MACROPAIN SUBUNIT C7-	(PF00227) - Proteasome A-type
		ALPHA) (PROTEINASE YSCE SUBUNIT 7) (MULTICATALYTIC	and B-type
		ENDOPEPTIDASE COMPLEX C7) (COMPONENT Y8) (SCL1
		SUPPRESSOR PROTEIN)
611	10186498 (6507, 6508)	Novel Protein sim. GBank gi|130880|sp|P23639|PRC3_YEAST -	Contains protein domain	protease	1023
		PROTEASOME COMPONENT Y7 (MACROPAIN SUBUNIT Y7)	(PF00227) - Proteasome A-type
		(PROTEINASE YSCE SUBUNIT 7) (MULTICATALYTIC	and B-type
		ENDOPEPTIDASE COMPLEX SUBUNIT Y7)
612	65674029 (8585, 8586)	Novel Protein sim. GBank gi|2252790 (U77784) - Lmp10 proteasome	Contains protein domain	protease	1008, 1014, 1020, 1035
		subunit [Mus musculus]	(PF00227) - Proteasome A-type
			and B-type
613	20696442 (559, 560)	Novel Protein sim. GBank gi|575457 (U17018) - Cdc40p [Saccharomyces	Contains protein domain	protease	1003
		cerevisiae]	(PF00400) - WD domain, G-beta
			repeat
614	94119776 (1269, 1270)	Novel Protein sim. GBank gi|1167860|emb|CAA93116| - (Z68888)		protease	1014
		Endoprotease FURIN [Spodoptera frugiperda]
615	10210483 (2673, 2674)	Novel Protein sim. GBank gi|2293464 (AF009645) - proteasome alpha		protease	1003
		subunit [Mycobacterium smegmatis]
616	65900232 (3531, 3532)	Novel Protein sim. GBank gi|2351374 (U54560) - putative 26S		protease	1014
		proteasome subunit athMOV34 [Arabidopsis thaliana]
617	80209080 (7199, 7200)	Novel Protein sim. GBank gi|2499849|sp|P55995|LON_HELPY - ATP-		protease	1050
		DEPENDENT PROTEASE LA
618	24140149 (495, 496)	Novel Protein sim. GBank gi|2499891|sp|P76403|YEGQ_ECOLI -		protease	1002
		PUTATIVE PROTEASE IN BAER-OGRK INTERGENIC REGION
619	11611585 (4063, 4064)	Novel Protein sim. GBank gi|4416302|gb|AAD20307| - (AF105716) copia-		protease	1022
		type pol polyprotein [Zea mays]
620	27964421 (5119, 5120)	Novel Protein sim. GBank gi|464859|sp|P33297|PRSA_YEAST - 26S		protease	1020, 1031
		PROTEASE REGULATORY SUBUNIT 6A (TAT-BINDING PROTEIN
		HOMOLOG 1) (TBP-1)
621	19518929 (919, 920)	Novel Protein sim. GBank gi|731574|sp|P38886|SUN1_YEAST - 26S		protease	1008
		PROTEASOME REGULATORY SUBUNIT SUN1
622	79842773 (8641, 8642)	Novel Protein sim. GBank gi|899394|emb|CAA90367| - (Z50048) unknown		protease	1004, 1006, 1024, 1035
		[Saccharomyces cerevislae]
623	20469812 (7119, 7120)			protease	1031
624	27975288 (7229, 7230)			porotease	1050
625	65891387 (8965, 8966)	Novel Protein sim. GBank gi|125520|sp|P01048|KNT1_RAT - T-	Contains protein domain	proteaseinhib	1007, 1051
		KININOGEN I PRECURSOR (MAJOR ACUTE PHASE PROTEIN)	(PF00031) - Cystatin domain
		(ALPHA-1-MAP) (THIOSTATIN) (CONTAINS: T-KININ)
626	17248503 (4639, 4640)	Novel Protein sim. GBank gi|772998|emb|CAA71412| - (Y10386) C1	Contains protein domain	proteaseinhib	1036
		inhibitor [Mus musculus]	(PF00079) - Serpins (serine
			protease inhibitors)
627	30659605 (5931, 5932)	Novel Protein sim. GBank gi|2507387|sp|P05544|CPI3_RAT -	Contains protein domain	proteaseinhib	1020
		CONTRAPSIN-LIKE PROTEASE INHIBITOR 3 PRECURSOR (CPI-23)	(PF00079) - Serpins (serine
		(SERINE PROTEASE INHIBITOR 1) (SPI-1)	protease inhibitors)
628	78741102 (2337, 2338)	Novel Protein sim. GBank gi|54173|emb|CAA40106| - (X56786)	Contains protein domain	proteaseinhib	1015, 1041
		contraspin [Mus musculus]	(PF00079) - Serpins (serine
			protease inhibitors)
629	78719449 (8877, 8878)	Novel Protein sim. GBank gi|285190|pir||A42210 - alpha-1-macroglobulin	Contains protein domain	proteaseinhib	1002, 1006, 1020, 1024
		precursor - rat	(PF00207) - Alpha-2-
		macroglobulin family
630	95087262 (339, 340)	Novel Protein sim. GBank gi|91949|pir||S15904 - alpha-1 proteinase	Contains protein domain	proteaseinhib	1003, 1004, 1006, 1007,
		inhibitor III, variant 1 precursor - rat	(PF00207) - Alpha-2-		1015, 1020, 1024
			macroglobulin family
631	78742120 (8441, 8442)	Novel Protein sim. GBank gi|112913|sp|P06238|A2MG_RAT - ALPHA-2-	Contains protein domain	proteaseinhib	1020
		MACROGLOBULIN PRECURSOR (ALPHA-2-M)	(PF01835) - Alpha-2-
			macroglobulin family N-terminal
			region
632	8483614 (6277, 6278)	Novel Protein sim. GBank gi|4539683|gb|AAD22172.1|AF09901 -	proteaseinhib		1020, 1022
		(AF099016) hepatocyte growth factor activator inhibitor type 2 [Mus
		musculus]
633	80499864 (4777, 4778)	Novel Protein sim. GBank gi|1174866|sp|P00127|UCRH_YEAST -	Contains protein domain	reductase	1002, 1003, 1004, 1006,
		UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 17 KD	(PF00010) - Helix-loop-helix DNA-		1010, 1020, 1021, 1022,
		PROTEIN (MITOCHONDRIAL HINGE PROTEIN) (COMPLEX III	binding domain		1024, 1028, 1031, 1035,
		POLYPEPTIDE VI)			1036, 1041
634	82178166 (4109, 4110)	Novel Protein sim. GBank gi|2498064|sp|Q12746|YMM5_YEAST -	Contains protein domain	reductase	1001, 1002, 1003, 1004,
		HYPOTHETICAL 35.3 KD PROTEIN IN HMGS-TUB3 INTERGENIC	(PF00175) - Oxidoreductase		1006, 1007, 1014, 1020,
		REGION	FAD/NAD-binding domain		1021, 1022, 1031, 1041
635	80227721 (3483, 3484)	Novel Protein sim. GBank gi|585542|sp|P38626|NC5R_YEAST -	Contains protein domain	reductase	1020, 1031
		PUTATIVE NADH-CYTOCHROME B5 REDUCTASE (P35)	(PF00175) - Oxidoreductase
			FAD/NAD-binding domain
636	79570706 (1655, 1656)	Novel Protein sim. GBank gi|4007669|emb|CAA22355| - (AL034443)	Contains protein domain	reductase	1015
		putative oxidoreductase [Streptomyces coelicolor]	(PF00248) - Aldo/keto reductase
			family
637	80192761 (2631, 2632)	Novel Protein sim. GBank gi|401472|sp|P308631|YAFB_ECOLI -	Contains protein domain	reductase	1055
		HYPOTHETICAL OXIDOREDUCTASE IN ASPU-MLTD INTERGENIC	(PF00248) - Aldo/keto reductase
		REGION	family
638	79581728 (6427, 6428)	Novel Protein sim. GBank gi|3329298 (AE001355) - Ribonucleoside	Contains protein domain	reductase	1014, 1020, 1028, 1051
		Reductase, Small Chain [Chlamydia trachomatis]	(PF00268) - Ribonucleotide
			reductases
639	78739067 (2989, 2990)	Novel Protein sim. GBank gi|1075225|pir||B64135 - ribonucleoside -	Contains protein domain	reductase	1020
		diphosphate reductase 1 alpha chain (nrdA) homolog - Haemophilus	(PF00317) - Ribonucleotide
		influenzae (strain Rd KW20)	reductase
640	79183351 (3167, 3168)	Novel Protein sim. GBank gi|417657|sp|Q03604|RIR1_CAEEL -	Contains protein domain	reductase	1022
		PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE	(PF00317) - Ribonucleotide
		CHAIN (RIBONUCLEOTIDE REDUCTASE)	reductase
641	80080919 (3257, 3258)	Novel Protein sim. GBank gi|66408|pir||RDEC1R - ribonucleoside-	Contains protein domain	reductase	1004, 1031
		diphosphate reductase (EC 1.17.4.1) alpha chain - Escherichia coli	(PF00317) - Ribonucleotide
			reductase
642	21426814 (3225, 3226)	Novel Protein sim. GBank gi|1502421 (U59433) - 3-ketoacyl-acyl carrier	Contains protein domain	reductase	1020
		protein reductase [Bacillus subtilis]	(PF00516) - Envelope
			glycoprotein GP120
643	20296124 (903, 904)	Novel Protein sim. GBank gi|421256|pir||S34724 - probable	Contains protein domain	reductase	1031
		oxidoreductase - Serratia marcescens	(PF00678) - Short chain
			dehydrogenase/reductase C-
			terminus
644	80071440 (1701, 1702)	Novel Protein sim. GBank gi|114049|sp|P19480|AHPF_SALTY - ALKYL		reductase	1003, 1004, 1022, 1046
		HYDROPEROXIDE REDUCTASE SUBUNIT F (ALKYL
		HYDROPEROXIDE REDUCTASE F52A PROTEIN)
645	79885703 (2011, 2012)	Novel Protein sim. GBank gi|1351892|sp|P48360|ADRO_YEAST -		reductase	1015
		NADPH: ADRENODOXIN OXIDOREDUCTASE HOMOLOG PRECURSOR
		(ADRENODOXIN REDUCTASE HOMOLOG)
646	65679723 (3281, 3282)	Novel Protein sim. GBank gi|140583|sp|P18579|MURB_BACSU - UDP-N-		reductase	1014
		ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE (UDP-N
		ACETYLMURAMATE DEHYDROGENASE)
647	17293190 (1, 2)	Novel Protein sim. GBank gi|1655954 (U68759) - pentaerythritol		reductase	1036
		tetranitrate reductase [Enterobacter cloacae]
648	12999132 (8383, 8384)	Novel Protein sim. GBank gi|1730037|sp|P50171|KE6_MOUSE - KE6		reductase	1022
		PROTEIN (KE-6)
649	23329071 (1535, 1536)	Novel Protein sim. GBank gi|2078012|emb|CAB08443| - (Z95207) cysG2		reductase	1024
		[Mycobacterium tuberculosis]
650	11753877 (2129, 2130)	Novel Protein sim. GBank gi|2182004|emb|CAB09473| - (Z96072)		reductase	1020
		hypothetical protein Rv2713 [Mycobacterium tuberculosis]
651	79967649 (6803, 6804)	Novel Protein sim. GBank gi|2443331|dbj|BAA22375| - (D86491) Nfrl		reductase	1031
		[Xenopus laevis]
652	35608122 (8335, 8336)	Novel Protein sim. GBank gi|2851634|sp|Q50591|Y0D1_MYCTU -		reductase	1010, 1050
		HYPOTHETICAL 50.0 KD PROTEIN CY1A11.01
653	78786556 (6879, 6880)	Novel Protein sim. GBank gi|2909446|emb|CAA17334| - (AL021929)		reductase	1006
		fabG4 [Mycobacterium tuberculosis]
654	66726810 (5515, 5516)	Novel Protein sim. GBank gi|2995313|emb|CAA18341| - (AL022268)		reductase	1007
		ribonucleotide reductase [Streptomyces coelicolor]
655	11611599 (5991, 5992)	Novel Protein sim. GBank gi|3128336 (AF010496) - precorrin-6x		reductase	1022
		reductase [Rhodobacter capsulatus]
656	79821280 (5765, 5766)	Novel Protein sim. GBank gi|3243170 (AF060489) - initial dioxygenase		reductase	1041
		reductase subunit [Sphingomonas sp. CB3]
657	80052438 (7591, 7592)	Novel Protein sim. GBank gi|3402836|emb|CAA76082| - (Y16136) 2-		reductase	1008
		enoate reductase [Moorella thermoacetica]
658	30790620 (7347, 7348)	Novel Protein sim. GBank gi|34138841dbj|BAA32306| - (AB007930)		reductase	1002
		KIAA0461 perotein [Homo sapiens]
659	57523089 (7899, 7900)	Novel Protein sim. GBank gi|3659621 (AF052519) - c-di-GMP		reductase	1008, 1023
		phosphodiesterase A [Acetobacter xylinus]
660	80080009 (4441, 4442)	Novel Protein sim. GBank gi|3913675|sp|Q08908|FRE5_YEAST -		reductase	1006, 1015, 1020, 1024,
		FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 5			1031
		PRECURSOR
661	94141225 (3089, 3090)	Novel Protein sim. GBank gi|4008535|emb|CAA22504| - (AL034492)		reductase	1002
		putative oxidoreductase subunit [Streptomyces coelicolor]
662	78374813 (4175, 4176)	Novel Protein sim. GBank gi|4581047|gb|AAD24584.1|AF13480 -		reductase	1002
		(AF134807) putative dihydroflavonol reductase [Oryza sativa]
663	79910083 (5023, 5024)	Novel Protein sim. GBank gi|465606|sp|P33029|YEIQ_ECOLI -		reductase	1021
		HYPOTHETICAL 54.0 KD PROTEIN IN FRUB-RTN INTERGENIC
		REGION
664	56121079 (4625, 4626)	Novel Protein sim. GBank gi|4666287|dbj|BAA77214.1| - (D85764)		reductase	1006, 1007
		cytosolic monodehydroascorbate reductase [Oryza sativa]
665	20467312 (2713, 2714)	Novel Protein sim. GBank gi|4755082|gb|AAA25100.2| - (L06800) nitrate		reductase	1008
		reductase large subunit [Klebsiella oxytoca]
666	65472462 (2701, 2702)	Novel Protein sim. GBank gi|4803683|emb|CAB42663.1| - (AL049819)		reductase	1006, 1021, 1026
		pyrroline-5-carboxylate reductase [Streptomyces coelicolor]
667	86723714 (9053, 9054)	Novel Protein sim. GBank gi|5002128|gb|AAD37319.1|AF13517 -		reductase	1016, 1022
		(AF135170) dimethyl sulfoxide reductase subunit A [Yersinia pestis]
668	21436461 (6897, 6898)	Novel Protein sim. GBank gi|586489|sp|P38230|QOR_YEAST -		reductase	1020
		PROBABLE QUINONE OXIDOREDUCTASE (NADPH: QUINONE
		REDUCTASE)
669	34400197 (765, 766)	Novel Protein sim. GBank gi|797336 (U19620) - MocA [Agrobacterium		reductase	1047
		tumefaciens]
670	82483471 (6905, 6906)			reductase	1001
671	87451956 (1621, 1622)	Novel Protein sim. GBank gi|131770|sp|P14132|RS9_DICDI - 40S	Contains protein domain	ribosomalprot	1023, 1055
		RIBOSOMAL PROTEIN S9 (40S RIBOSOMAL PROTEIN 1024)	(PF00163) - Ribosomal protein
		VEGETATIVE SPECIFIC PROTEIN V12)	S4/S9 N-terminal domain
672	23333338 (7195, 7196)	Novel Protein sim. GBank gi|1173189|sp|P12340|RR12_MAIZE -	Contains protein domain	ribosomalprot	1050
		CHLOROPLAST 30S RIBOSOMAL PROTEIN S12	(PF00164) - Ribosomal protein
			S12
673	57529660 (47, 48)	Novel Protein sim. GBank gi|132854|sp|P02387|RL2_ECOLI - 50S	Contains protein domain	ribosomalprot	1010
		RIBOSOMAL PROTEIN L2	(PF00181) - Ribosomal Proteins
			L2
674	20446881 (3675, 3676)	Novel Protein sim. GBank gi|132869|sp|P11255|RL2_YERPS - 50S	Contains protein domain	ribosomalprot	1022
		RIBOSOMAL PROTEIN L2	(PF00181) - Ribosomal Proteins
			L2
675	20446870 (971, 972)	Novel Protein sim. GBank gi|2500275|sp|P55837|RL16_ACTAC - 50S	Contains protein domain	ribosomalprot	1022
		RIBOSOMAL PROTEIN L16	(PF00252) - Ribosomal protein
			L16
676	79328715 (899, 900)	Novel Protein sim. GBank gi|4506717|ref|NP_001023.1|pRPS2 -	Contains protein domain	ribosomalprot	1020, 1024, 1031
		ribosomal protein S29	(PF00253) - Ribosomal protein
			S14p/S29e
677	80235795 (585, 586)	Novel Protein sim. GBank gi|4808369|emb|CAB42783.1| - (AL049841)	Contains protein domain	ribosomalprot	1020, 1024, 1046, 1051
		putative 30S ribosomal protein S14 [Streptomyces coelicolor]	(PF00253) - Ribosomal protein
			S14p/S29e
678	66259277 (3993, 3994)	Novel Protein sim. GBank gi|134409|sp|P16336|SECY_BACSU -	Contains protein domain	ribosomalprot	1008
		PREPROTEIN TRANSLOCASE SECY SUBUNIT	(PF00256) - Ribosomal protein
			L15
679	28782039 (1319, 1320)	Novel Protein sim. GBank gi|132656|sp|P17079|RL12_YEAST - 60S	Contains protein domain	ribosomalprot	1020
		RIBOSOMAL PROTEIN L12 (YL15) (YL23)	(PF00298) - Ribosomal protein
			L11
680	39506897 (6867, 6868)	Novel Protein sim. GBank gi|3915843|sp|O31212|RS2_STRCO - 30S	Contains protein domain	ribosomalprot	1003
		RIBOSOMAL PROTEIN S2	(PF00318) - Ribosomal protein S2
681	71845367 (3025, 3026)	Novel Protein sim. GBank gi|417336|sp|P32905|NABA_YEAST - 40S	Contains protein domain	ribosomalprot	1020, 1022
		RIBOSOMAL PROTEIN SA HOMOLOG A (NUCLEIC ACID-BINDING	(PF00318) - Ribosomal protein S2
		PROTEIN NAB1A)
682	11764585 (4411, 4412)	Novel Protein sim. GBank gi|1173281|sp|P44377|RS8_HAEIN - 30S	Contains protein domain	ribosomalprot	1004
		RIBOSOMAL PROTEIN S8	(PF00410) - Ribosomal protein S8
683	79574512 (1263, 1264)	Novel Protein sim. GBank gi|282575|pir||S27686 - tcmR protein -	Contains protein domain	ribosomalprot	1028
		Streptomyces glaucescens	(PF00440) - Bacterial regulatory
			proteins, tetR family
684	20117349 (641, 642)	Novel Protein sim. GBank gi|4981571|gb|AAD36107.1|AE00176 -	Contains protein domain	ribosomalprot	1008
		(AE001764) transcriptional regulator, TetR family [Thermotoga maritima]	(PF00440) - Bacterial regulatory
			proteins, tetR family
685	77644732 (2041, 2042)	Novel Protein sim. GBank gi|4981571|gb|AAD36107.1|AE00176 -	Contains protein domain	ribosomalprot	1020
		(AE001764) transcriptional regulator, TetR family [Thermotoga maritima]	(PF00440) - Bacterial regulatory
			proteins, tetR family
686	16777917 (8423, 8424)	Novel Protein sim. GBank gi|585949|sp|P21468|RS6_BACSU - 30S	Contains protein domain	ribosomalprot	1041
		RIBOSOMAL PROTEIN S6 (BS9)	(PF01250) - Ribosomal protein S6
687	16307733 (3357, 3358)	Novel Protein sim. GBank gi|730459|sp|P39939|R26B_YEAST - 40S	Contains protein domain	ribosomalprot	1050
		RIBOSOMAL PROTEIN S26E-B	(PF01283) - Ribosomal protein
			S26e
688	95294566 (4501, 4502)	Novel Protein sim. GBank gi|3581854|emb|CAA20810| - (AL031541) 50S	Contains protein domain	ribosomalprot	1008, 1010, 1021, 1028,
		ribosomal protein L35 [Streptomyces coelicolor]	(PF01632) - Ribosomal protein		1031, 1035
			L35
689	78904615 (7431, 7432)	Novel Protein sim. GBank gi|4506635|ref|NP_000985.1|pRPL3 -	Contains protein domain	ribosomalprot	1006
		ribosomal protein L32	(PF01655) - Ribosomal protein
			L32
690	71088544 (8127, 8128)	Novel Protein sim. GBank gi|4007730|emb|CAA22414| - (AL034447) 50S	Contains protein domain	ribosomalprot	1026, 1050
		ribosomal protein L32 [Streptomyces coelicolor]	(PF01783) - Ribosomal L32p
			protein family
691	80079735 (6531, 6532)	Novel Protein sim. GBank gi|129021|sp|P20964|OBG_BACSU - SPO0B-		ribosomalprot	1024, 1031
		ASSOCIATED GTP-BINDING PROTEIN
692	24119415 (879, 880)	Novel Protein sim. GBank gi|1321944|emb|CAA66033| - (X97346) FCYX		ribosomalprot	1041
		[Saccharomyces cerevislae]
693	82439815 (3063, 3064)	Novel Protein sim. GBank gi|133030|sp|P02418|RL9_ECOLI - 50S		ribosomalprot	1001
		RIBOSOMAL PROTEIN L9
694	28375899 (1001, 1002)	Novel Protein sim. GBank gi|1351010|sp|P48164|RS7_YEAST -		ribosomalprot	1041
		PROBABLE 40S RIBOSOMAL PROTEIN S7
695	29017613 (2725, 2726)	Novel Protein sim. GBank gi|1352915|sp|P47151|YJ84_YEAST -		ribosomalprot	1041
		HYPOTHETICAL 14.0 KD PROTEIN IN NNF1-STE24 INTERGENIC
		REGION
696	30402257 (2563, 2564)	Novel Protein sim. GBank gi|1710566|sp|P51998|RL4P_YEAST -		ribosomalprot	1006
		PUTATIVE L4P LIKE RIBOSOMAL PROTEIN
697	78466595 (5189, 5190)	Novel Protein sim. GBank gi|2500312|sp|P96385|RL25_MYCTU -		ribosomalprot	1006
		PROBABLE 50S RIBOSOMAL PROTEIN L25
698	17294099 (4153, 4154)	Novel Protein sim. GBank gi|3024573|sp|P56355|RR7_CHLVU -		ribosomalprot	1006
		CHLOROPLAST 30S RIBOSOMAL PROTEIN S7
699	56321652 (7115, 7116)	Novel Protein sim. GBank gi|3212879 (AC004005) - putative ribosomal		ribosomalprot	1041
		protein L7 [Arabidopsis thaliana]
700	86684973 (769, 770)	Novel Protein sim. GBank gi|3377797 (AF075597) - Similar to 60S		ribosomalprot	1016
		ribosome protein L19; coded for by A. thaliana cDNA T04719; coded for
		by A. thaliana cDNA H36046; coded for by A. thaliana cDNA T44067;
		coded for by A. thaliana cDNA T14056; coded for by A. thaliana cDNA
		R90691 [Ara . . .
701	81079398 (285, 286)	Novel Protein sim. GBank gi|3982|emb|CAA37834| - (X53841)		ribosomalprot	1001, 1004, 1010, 1015,
		mitochondrial ribosomal protein YmL8 [Saccharomyces cerevisiae]			1020, 1021, 1022, 1024,
					1028, 1031, 1035, 1036,
					1051
702	13081834 (6335, 6336)	Novel Protein sim. GBank gi|4680695|gb|AAD27737.1|AF13296 -		ribosomalprot	1022
		(AF132962) CGI-28 protein [Homo sapiens]
703	20736808 (2933, 2934)	Novel Protein sim. GBank gi|4808405|emb|CAB42737.1| - (AL049826)		ribosomalprot	1020
		putative 50S ribosomal protein L9 [Streptomyces coelicolor]
704	87454340 (6057, 6058)	Novel Protein sim. GBank gi|548774|sp|P35685|RL7A_ORYSA - 60S		ribosomalprot	1015, 1022, 1023
		RIBOSOMAL PROTEIN L7A
705	27824087 (6421, 6422)	Novel Protein sim. GBank gi|548791|sp|P22354|RM20_YEAST -		ribosomalprot	1003, 1004, 1022, 1031
		MITOCHONDRIAL 60S RIBOSOMAL PROTEIN L20 PRECURSOR
		(YML20)
706	80082633 (2067, 2068)	Novel Protein sim. GBank gi|606342 (U18997) - ORF_o622; reading		ribosomalprot	1020, 1031
		frame open far upstream of start; possible frameshift, linking to previous
		ORF [Escherichia coli]
707	11101408 (2085, 2086)	Novel Protein sim. GBank gi|2506239|sp|P23852|HEPA_ECOLI - RNA	Contains protein domain	mapolymerase	1004
		POLYMERASE ASSOCIATED PROTEIN (ATP-DEPENDENT HELICASE	(PF00271) - Helicases conserved
		HEPA)	C-terminal domain
708	21398399 (3437, 3438)	Novel Protein sim. GBank gi|133370|sp|P17890|RPC8_YEAST - DNA-		mapolymerase	1020
		DIRECTED RNA POLYMERASE III 31 KD POLYPEPTIDE (C31)
709	79834964 (3895, 3896)	Novel Protein sim. GBank gi|133418|sp|P19175|RPOB_PSEPU - DNA-		mapolymerase	1036
		DIRECTED RNA POLYMERASE BETA CHAIN (TRANSCRIPTASE BETA
		CHAIN) (RNA POLYMERASE BETA SUBUNIT)
710	80065066 (5839, 5840)	Novel Protein sim. GBank gi|133418|sp|P19175|RPOB_PSEPU - DNA-		mapolymerase	1007, 1022
		DIRECTED RNA POLYMERASE BETA CHAIN (TRANSCRIPTASE BETA
		CHAIN) (RNA POLYMERASE BETA SUBUNIT)
711	80219418 (4987, 4988)	Novel Protein sim. GBank gi|133457|sp|P13433|RPOM_YEAST - DNA-		mapolymerase	1003, 1004, 1020, 1022,
		DIRECTED RNA POLYMERASE MITOCHONDRIAL PRECURSOR			1031
712	11077563 (2329, 2330)	Novel Protein sim. GBank gi|1350855|sp|P19176|RPOC_PSEPU - DNA-		mapolymerase	1022
		DIRECTED RNA POLYMERASE BETA' CHAIN (TRANSCRIPTASE
		BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT)
713	80255174 (4695, 4696)	Novel Protein sim. GBank gi|1711571|sp|P54000|SUB1_YEAST - SUB1		mapolymerase	1020
		PROTEIN
714	20293171 (445, 446)	Novel Protein sim. GBank gi|1938356 (U82763) - RpoD [Xanthomonas		mapolymerase	1031
		campestris pv. campestris]
715	65681535 (1317, 1318)	Novel Protein sim. GBank gi|2317257|dbj|BAA21740| - (AB005891) ORF2		mapolymerase	1022
		[Platemys spixli]
716	80420315 (8057, 8058)	Novel Protein sim. GBank gi|2500608|sp|Q51561|RPOB_PSEAE - DNA-		mapolymerase	1023
		DIRECTED RNA POLYMERASE BETA CHAIN (TRANSCRIPTASE BETA
		CHAIN) (RNA POLYMERASE BETA SUBUNIT)
717	9906510 (1205, 1206)	Novel Protein sim. GBank gi|2506239|sp|P23852|HEPA_ECOLI - RNA		mapolymerase	1002
		POLYMERASE ASSOCIATED PROTEIN (ATP-DEPENDENT HELICASE
		HEPA)
718	80026079 (1373, 1374)	Novel Protein sim. GBank gi|3249729 (AF071795) - RNA polymerase		mapolymerase	1003, 1004, 1008, 1010,
		sigma-like factor [Streptomyces bluensis]			1022, 1031
719	79835134 (2757, 2758)	Novel Protein sim. GBank gi|3549149 (AF087812) - RNA polymerase B-		mapolymerase	1036
		subunit [Legionella Pneumophila]
720	88094878 (3445, 3446)	Novel Protein sim. GBank gi|3660649 (U86688) - RNA polymerase beta-		mapolymerase	1022
		subunit [Coxiella bumetil]
721	21147471 (4015, 4016)	Novel Protein sim. GBank gi|3878613|emb|CAB05571| - (Z83117) similar		mapolymerase	1055
		to reverse transcriptase [Caenorhabditis elegans]
722	30654004 (6891, 6892)	Novel Protein sim. GBank gi|3914808|sp|O35134|RPA1_MOUSE - DNA-		mapolymerase	1008
		DIRECTED RNA POLYMERASE I LARGEST SUBUNIT (RNA
		POLYMERASE I 194 KD SUBUNIT) (RPA194)
723	5498584 (4869, 4870)	Novel Protein sim. GBank gi|401019|sp|P30761|RPOC_MYCLE - DNA-		mapolymerase	1055
		DIRECTED RNA POLYMERASE BETA' CHAIN (TRANSCRIPTASE
		BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT)
724	20447155 (8529, 8530)	Novel Protein sim. GBank gi|401019|sp|P30761|RPOC_MYCLE - DNA-		mapolymerase	1022
		DIRECTED RNA POLYMERASE BETA' CHAIN (TRANSCRIPTASE
		BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT)
725	19882932 (6519, 6520)	Novel Protein sim. GBank gi|4539660|gb|AAD22153.1|AF06128 -		mapolymerase	1001
		(AF061282) polyprotein [Sorghum bicolor]
726	13528587 (2445, 2446)	Novel Protein sim. GBank gi|5305777|gb|AAD41810.1|AF14409 -		mapolymerase	1022
		(AF144091) sigma factor SigH [Mycobacterium smegmatis]
727	30263251 (2035, 2036)	Novel Protein sim. GBank gi|57255|emb|CAA48786| - (X69021)		mapolymerase	1006
		senescence marker protein-30 [Rattus norvegicus]
728	21662065 (6459, 6460)	Novel Protein sim. GBank gi|3136057|emb|CAA19116| - (AL023592) actin	Contains protein domain	struct	1008
		like protein [Schizosaccharomyces pombe]	(PF00022) - Actin
729	54968624 (6467, 6468)	Novel Protein sim. GBank gi|1839052|emb|CAA69604| - (Y08296)	Contains protein domain	struct	1034
		integumentary mucin B.1 [Xenopus laevis]	(PF00084) - Sushi domain (SCR
			repeat)
730	52559797 (6733, 6734)	Novel Protein sim. GBank gi|285329|pir||A42112 - mucin-like peptide MLP	Contains protein domain	struct	1020, 1022
		2677 - rat	(PF00093) - von Willebrand factor
			type C domain
731	80431450 (1217, 1218)	Novel Protein sim. GBank gi|1703701|bbs|178462 - KRP5 = kinesin-related	Contains protein domain	struct	1002, 1015, 1022, 1035,
		protein [rats, testes, Peptide Partial, 167 aa]	(PF00225) - Kinesin motor		1036
			domain
732	80053179 (1435, 1436)	Novel Protein sim. GBank gi|2062752 (U92845) - kinesin motor protein	Contains protein domain	struct	1008
		[Ustilago maydis]	(PF00225) - Kinesin motor
			domain
733	10247640 (111, 112)	Novel Protein sim. GBank gi|3413892|dbj|BAA32310| - (AB007934)	Contains protein domain	struct	1036
		KIAA0465 protein [Homo sapiens]	(PF00435) - Spectrin repeat
734	80419225 (435, 436)	Novel Protein sim. GBank gi|127736|sp|P19524|MYS2_YEAST - MYOSIN	Contains protein domain	struct	1004, 1006, 1010, 1023
		2 ISOFORM	(PF00612) - IQ calmodulin
			binding motif
735	10199185 (7473, 7474)	Novel Protein sim. GBank gi|311159 (L16243) - synaptobrevin	Contains protein domain	struct	1004
		[Saccharomyces cerevisiae]	(PF00957) - Synaptobrevin
736	78903874 (7203, 7204)	Novel Protein sim. GBank gi|1017427|emb|CAA62189| - (X90569) elastic		struct	1041
		titin [Homo sapiens]
737	11131571 (7401, 7402)	Novel Protein sim. GBank gi|1079451|pir||A55463 - tropomodulin, skeletal		struct	1022
		muscle - chicken
738	95010667 (1195, 1196)	Novel Protein sim. GBank gi|1091582|prf||2021268A - elongation factor		struct	1002, 1004, 1010, 1015,
		[Streptomyces coelicolor]			1022, 1031, 1036, 1046
739	32149138 (611, 612)	Novel Protein sim. GBank gi|112958|sp|P18091|AACT_DROME - ALPHA-		struct	1002, 1041, 1051
		ACTININ, SARCOMERIC (F-ACTIN CROSS LINKING PROTEIN)
740	80239644 (7415, 7416)	Novel Protein sim. GBank gi|2143863|pir||B57431 - myosin-binding C-		struct	1003, 1004
		protein - rat (fragment)
741	19464113 (177, 178)	Novel Protein sim. GBank gi|2808506|emb|CAA12536.1| - (AJ225561)		struct	1021
		ExsG protein [Sinorhizobium meliloti]
742	27843681 (2955, 2956)	Novel Protein sim. GBank gi|285329|pir||A42112 - mucin-like peptide MLP		struct	1003, 1022
		2677 - rat
743	80252997 (8005, 8006)	Novel Protein sim. GBank gi|2950347|emb|CAA04492| - (AJ001038) M-		struct	1015, 1020
		protein [Mus musculus]
744	20372385 (4239, 4240)	Novel Protein sim. GBank gi|3649753|emb|CAB11102.1| - (Z98547)		struct	1020
		predicted using hexExon; MAL3P3.2 (PFC0330w), PDZ domain protein,
		len: 700 aa [Plasmodium falciparum]
745	23206163 (1537, 1538)	Novel Protein sim. GBank gi|399308|sp|Q01377|CSP1_CORGL - PS1		struct	1024
		PROTEIN PRECURSOR
746	88085671 (5081, 5082)	Novel Protein sim. GBank gi|4503581|ref|NP_001969.1|pEPB4 -		struct	1020
		erythrocyte membrane protein band 4.9 (dematin)
747	85801312 (947, 948)			struct	1023
748	78680455 (7527, 7528)	Novel Protein sim. GBank gi|1711601|sp|P49889|SUO3_RAT -		sulfotransferase	1007
		ESTROGEN SULFOTRANSFERASE, ISOFORM 3 (EST-3)
		(SULFOTRANSFERASE, ESTROGEN-PREFERRING) (ESTRONE
		SULFOTRANSFERASE)
749	56465618 (5803, 5804)	Novel Protein sim. GBank gi|3449294|dbj|BAA32462| - (AB011532)	Contains protein domain	synthase	1015
		MEGF6 [Rattus norvegicus]	(PF00008) - EGF-like domain
750	80105992 (3361, 3362)	Novel Protein sim. GBank gi|477532|pir||A49175 - Motch B protein -	Contains protein domain	synthase	1036
		mouse (fragment)	(PF00008) - EGF-like domain
751	37799246 (6091, 6092)	Novel Protein sim. GBank gi|1493807 (U35068) - PtxR [Pseudomonas	Contains protein domain	synthase	1010
		aeruginosa]	(PF00126) - Bacterial regulatory
			helix-turn-helix protein, lysR family
752	80086821 (1281, 1282)	Novel Protein sim. GBank gi|1881244|dbj|BAA19271| - (AB001488)	Contains protein domain	synthase	1031
		SIMILAR TO PYRUVATE OXIDASE AND ACETOLACTATE SYNTHASE.	(PF00205) - Thiamine
		[Bacillus subtilis]	pyrophosphate enzymes
753	80248088 (4907, 4908)	Novel Protein sim. GBank gi|1881244|dbj|BAA19271| - (AB001488)	Contains protein domain	synthase	1004, 1020
		SIMILAR TO PYRUVATE OXIDASE AND ACETOLACTATE SYNTHASE.	(PF00205) - Thiamine
		[Bacillus subtilis]	pyrophosphate enzymes
754	20292172 (1615, 1616)	Novel Protein sim. GBank gi|114580|sp|P00831|ATPD_ECOLI - ATP	Contains protein domain	synthase	1031
		SYNTHASE DELTA CHAIN	(PF00213) - ATP synthase delta
			(OSCP) subunit
755	11356059 (6911, 6912)	Novel Protein sim. GBank gi|173045 (K01386) - anthranilate synthase	Contains protein domain	synthase	1055
		Component II: Indole-3-glycerol phosphate synthase (TRP3)	(PF00218) - Indole-3-glycerol
		[Saccharomyces cerevisiae]	phosphate synthases
756	86685863 (5129, 5130)	Novel Protein sim. GBank gi|3722219|gb|AAC63500.1| - (AF054585)	Contains protein domain	synthase	1024, 1026
		indoleglycerol phosphate synthase [Streptomyces coelicolor]	(PF00218) - Indole-3-glycerol
			phosphate synthases
757	20465640 (1757, 1758)	Novel Protein sim. GBank gi|2126911|pir||40381 - citrate synthase II -	Contains protein domain	synthase	1008
		Bacillus subtilis	(PF00285) - Citrate synthase
758	38335891 (8183, 8184)	Novel Protein sim. GBank gi|5441892|dbj|BAA82390.1| - (AP000367)	Contains protein domain	synthase	1006
		ESTs C96653(C10531), C96654(C10531), C28571(C61641) correspond to	(PF00285) - Citrate synthase
		a region of the predicted gene.; Similar to citrate synthetase. (AC004521)
		[Oryza sativa]
759	20294369 (7221, 7222)	Novel Protein sim. GBank gi|1750387 (U81259) - carbamoylphosphate	Contains protein domain	synthase	1031
		synthetase large subunit [Pseudomonas aeruginosa]	(PF00289) - Carbamoyl-
			phosphate synthase (CPSase)
760	94631714 (5533, 5534)	Novel Protein sim. GBank gi|417496|sp|P33158|PMGY_STRCO -	Contains protein domain	synthase	1028
		PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	(PF00300) - Phosphoglycerate
		(PGAM) (BPG-DEPENDENT PGAM)	mutase family
761	17891833 (6613, 6614)	Novel Protein sim. GBank g|136618|sp|P06785|TYSY_YEAST -	Contains protein domain	synthase	1021
		THYMIDYLATE SYNTHASE (TS)	(PF00303) - Thymidylate
			synthase
762	71095141 (3041, 3042)	Novel Protein sim. GBank gi|3449252|emb|CAA20396| - (AL031317)	Contains protein domain	synthase	1050
		glucosamine-fructose-6-phosphate aminotransferase [Streptomyces	(PF00310) - Glutamine
		coelicolor]	amidotransferases class-II
763	82471218 (4409, 4410)	Novel Protein sim. GBank gi|114954|sp|P15703|BGL2_YEAST - GLUCAN	Contains protein domain	synthase	1001, 1003, 1004, 1006,
		1,3-BETA-GLUCOSIDASE PRECURSOR (EXO-1,3-BETA-GLUCANASE)	(PF00332) - Glycosyl hydrolases		1007,1008, 1010, 1015,
		(GP29)	family 17		1020, 1022, 1035, 1041
764	9537334 (973, 974)	Novel Protein sim. GBank gi|3927835 (AC005727) - similar to	Contains protein domain	synthase	1020
		Streptomyces PapA [Arabidopsis thaliana]	(PF00425) - chorismate binding
			enzyme
765	79968318 (8287, 8288)	Novel Protein sim. GBank gi|477849|pir||B48967 - anthranilate synthase	Contains protein domain	synthase	1020
		(EC 4.1.3.27) component I - Corynebacterium glutamicum	(PF00425) - chorismate binding
			enzyme
766	82052429 (7033, 7034)	Novel Protein sim. GBank gi|1170939|sp|P43282|METM_LYCES - S-	Contains protein domain	synthase	1014, 1024
		ADENOSYLMETHIONINE SYNTHETASE 3 (METHIONINE	(PF00438) - S-
		ADENOSYLTRANSFERASE 3) (ADOMET SYNTHETASE 3)	adenosylmethionine synthetase
767	80043700 (3103, 3104)	Novel Protein sim. GBank gi|2498499|sp|P56060|KDSA_HELPY - 2-	Contains protein domain	synthase	1050
		DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE (PHOSPHO-2-	(PF00484) - Prokaryotic-type
		DEHYDRO-3-DEOXYOCTONATE ALDOLASE) (3-DEOXY-D-MANNO-	carbonic anhydrases
		OCTULOSONIC ACID 8-PHOSPHATE SYNTHETASE) (KDO 8-P
		SYNTHASE)
768	79562866 (3031, 3032)	Novel Protein sim. GBank gi|4884830|gb|AAD31824.1|AF13119 -	Contains protein domain	synthase	1021
		(AF131199) porphobilinogen deaminase [Pseudomonas syringae pv.	(PF00487) - Fatty acid desaturase
		syringae]
769	11394712 (5465, 5466)	Novel Protein sim. GBank gi|3660334|pdb|2GAR| - A Ph-Dependent	Contains protein domain	synthase	1020
		Stabilzation Of An Active Site Loop Observed From Low And High Ph	(PF00551) - Formyl transferase
		Crystal Structures Of Mutant Monomeric Glycinamide Ribonucleotide
		Transformylase
770	78459786 (1771, 1772)	Novel Protein sim. GBank gi|119783|sp|P14926|FABB_ECOLI - 3-	Contains protein domain	synthase	1024
		OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I (BETA-KETOACYL	(PF00553) - Cellulose binding
		ACP SYNTHASE I) (KAS I)	domain
771	80252645 (2153, 2154)	Novel Protein sim. GBank gi|1144520 (U34956) -	Contains protein domain	synthase	1004, 1008, 1021, 1022
		phosphoribosylformylglycinamidine synthase [Mycobacterium	(PF00586) - AIR synthase related
		tuberculosis]	protein
772	13085297 (8811, 8812)	Novel Protein sim. GBank gi|2494764|sp|Q50729|GUAA_MYCTU - GMP	Contains protein domain	synthase	1010, 1022
		SYNTHASE (GLUTAMINE-HYDROLYZING) (GLUTAMINE	(PF00958) - GMP synthase C
		AMIDOTRANSFERASE) (GMP SYNTHETASE)	terminal domain
773	79846152 (4969, 4970)	Novel Protein sim. GBank gi|2687651 (AF036932) - 3-dehydroquinate	Contains protein domain	synthase	1031
		dehydratase [Corynebacterium glutamicum]	(PF01220) - Dehydroquinase
			class II
774	80235940 (3679, 3680)	Novel Protein sim. GBank gi|115944|sp|P06182|CCHL_YEAST -	Contains protein domain	synthase	1004, 1020
		CYTOCHROME C HEME LYASE (CCHL) (HOLOCYTOCHROME-C	(PF01265) - Cytochrome c/c1
		SYNTHASE)	heme lyase
775	80040519 (7139, 7140)	Novel Protein sim. GBank gi|461698|sp|P33322|CBF5_YEAST -	Contains protein domain	synthase	1002, 1003
		CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5	(PF01472) - PUA domain
		(CENTROMERE-BINDING FACTOR 5) (NUCLEOLAR PROTEIN CBF5)
		(P64′)
776	80250627 (7905, 7906)	Novel Protein sim. GBank gi|2687633 (AF035756) - 2-dehydro-3-	Contains protein domain	synthase	1003, 1006, 1008, 1020,
		deoxyphosphoheptonate aldolase; phospho-2-dehydro-3-deoxyheptonate	(PF01474) - Class-II DAHP		1022, 1024, 1026, 1031,
		aldolase [Streptomyces sp.]	synthetase family		1050
777	20438343 (3123, 3124)	Novel Protein sim. GBank gi|1850941 (U54794) - Orp [Pseudomonas	Contains protein domain	synthase	1008
		aeruginosa]	(PF01509) - TruB family
			pseudouridylate synthase (N
			terminal domain)
778	80216341 (7071, 7072)	Novel Protein sim. GBank gi|116382|sp|P14180|CHS2_YEAST - CHITIN	Contains protein domain	synthase	1001, 1002, 1003, 1004,
		SYNTHASE 2 (CHITIN-UDP ACETYL-GLUCOSAMINYL TRANSFERASE	(PF01644) - Chitin synthase		1006, 1020, 1021, 1022,
		2)			1036, 1041
779	66770266 (4779, 4780)	Novel Protein sim. GBank gi|114179|sp|P07637|AROA_SALTY - 3-		synthase	1046
		PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE (5-
		ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP
		SYNTHASE)
780	86471563 (573, 574)	Novel Protein sim. GBank gi|114421|sp|P17614|ATP2_NICPL - ATP		synthase	1017
		SYNTHASE BETA CHAIN, MITOCHONDRIAL PRECURSOR
781	95288987 (1877, 1878)	Novel Protein sim. GBank gi|1144520 (U34956) -		synthase	1002, 1003, 1004, 1008,
		phosphoribosylformylglycinamidine synthase [Mycobacterium			1020, 1022, 1031
		tuberculosis]
782	78676796 (5225, 5226)	Novel Protein sim. GBank gi|1144522 (U34957) -		synthase	1006
		phosphoribosylaminoimidazolesuccinocarboxamide synthase
		[Mycobacterium tuberculosis]
783	79378861 (8781, 8782)	Novel Protein sim. GBank gi|114511|sp|P19482|ATPA_BOVIN - ATP		synthase	1020, 1022, 1024
		SYNTHASE ALPHA CHAIN, LIVER ISOFORM, MITOCHONDRIAL
		PRECURSOR
784	8489430 (781, 782)	Novel Protein sim. GBank gi|115208|sp|P07245|C1TC_YEAST - C-1-		synthase	1020
		TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF
		SYNTHASE) (METHYLENETETRAHYDROFOLATE DEHYDROGENASE/
		METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE/
		FORMYLTETRAHYDROFOLATE SYNTHETASE
785	78793853 (2391, 2392)	Novel Protein sim. GBank gi|115208|sp|P07245|C1TC_YEAST - C-1-		synthase	1025, 1041
		TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1 -THF
		SYNTHASE) (METHYLENETETRAHYDROFOLATE DEHYDROGENASE/
		METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE/
		FORMYLTETRAHYDROFOLATE SYNTHETASE
786	78760458 (7255, 7256)	Novel Protein sim. GBank gi|115208|sp|P07245|C1TC_YEAST - C-1-		synthase	1041
		TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF
		SYNTHASE) (METHYLENETETRAHYDROFOLATE DEHYDROGENASE/
		METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE/
		FORMYLTETRAHYDROFOLATE SYNTHETASE
787	78523866 (7525, 7526)	Novel Protein sim. GBank gi|115620|sp|P25993|CARA_BACSU -		synthase	1006, 1024
		CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC,
		SMALL CHAIN (CARBAMOYL-PHOSPHATE SYNTHETASE
		GLUTAMINE CHAIN)
788	15019489 (411, 412)	Novel Protein sim. GBank gi|1169215|sp|P43797|DAPA_HAEIN -		synthase	1051
		DIHYDRODIPICOLINATE SYNTHASE (DHDPS)
789	78778172 (3465, 3466)	Novel Protein sim. GBank gi|1170917|sp|P44612|MEND_HAEIN - 2-		synthase	1007
		SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE
		SYNTHASE (SHCHC SYNTHASE)/2-OXOGLUTARATE
		DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE)
		(KDC)
790	13085914 (3913, 3914)	Novel Protein sim. GBank gi|1172792|sp|P44341|PYRG_HAEIN - CTP		synthase	1020
		SYNTHASE (UTP-AMMONIA LIGASE) (CTP SYNTHETASE)
791	25256587 (8259, 8260)	Novel Protein sim. GBank gi|1174692|sp|P45837|THRC_MYCLE -		synthase	1002
		PROBABLE THREONINE SYNTHASE
792	9873395 (5667, 5668)	Novel Protein sim. GBank gi|1175639|sp|P44433|RLUC_HAEIN -		synthase	1041
		RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE C
		(PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)
793	82063898 (1737, 1738)	Novel Protein sim. GBank gi|119832|sp|P19097|FAS2_YEAST - FATTY		synthase	1001, 1002, 1003, 1004,
		ACID SYNTHASE, SUBUNIT ALPHA [CONTAINS: EC 1.1.1.100; EC			1006, 1007, 1008, 1010,
		2.3.1.41]			1014, 1015, 1020, 1021,
					1022, 1024, 1025, 1028,
					1031, 1035, 1036, 1041,
					1046
794	80241674 (8587, 8588)	Novel Protein sim. GBank gi|123330|sp|P22791|HMCM_RAT -		synthase	1003, 1022
		HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL
		PRECURSOR (HMG-COA SYNTHASE) (3-HYDROXY-3-
		METHYLGLUTARYL COENZYME A SYNTHASE)
795	65460215 (6121, 6122)	Novel Protein sim. GBank gi|1346930|sp|P48795|PYRC_LACLE -		synthase	1014
		DIHYDROOROTASE (DHOASE)
796	79862380 (8803, 8804)	Novel Protein sim. GBank gi|135108|sp|P15189|SYE_RHIME -		synthase	1010, 1028
		GLUTAMYL-TRNA SYNTHETASE (GLUTAMATE-TRNA LIGASE)
		(GLURS)
797	80250273 (6225, 6226)	Novel Protein sim. GBank gi|1360669|pir||CGHU1V - collagen alpha 1(V)		synthase	1050
		chain precursor - human
798	78389393 (7121, 7122)	Novel Protein sim. GBank gi|136753|sp|P23337|UGS1_YEAST -		synthase	1020
		GLYCOGEN (STARCH) SYNTHASE, ISOFORM 1
799	8365947 (2349, 2350)	Novel Protein sim. GBank gi|1709961|sp|P53529|PYRG_MYCLE - CTP		synthase	1022
		SYNTHASE (UTP-AMMONIA LIGASE) (CTP SYNTHETASE)
800	88095289 (905, 906)	Novel Protein sim. GBank gi|1731277|sp|Q10807|YX12_MYCTU -		synthase	1031
		HYPOTHETICAL 32.0 KD PROTEIN CY274.12C
801	3377208 (3279, 3280)	Novel Protein sim. GBank gi|1781097|emb|CAB06231| - (Z83864) gltB		synthase	1010
		[Mycobacterium tuberculosis]
802	19887737 (1531, 1532)	Novel Protein sim. GBank gi|2326953 (U55242) - alpha-D-glucose-1-		synthase	1001
		phosphate thymidylyltransferase [Mycobacterium tuberculosis]
803	10871801 (5453, 5454)	Novel Protein sim. GBank gi|2384564 (U70470) - beta-ketoacyl-ACP		synthase	1028
		synthase I [Pseudomonas aeruginosa]
804	35893282 (1313, 1314)	Novel Protein sim. GBank gi|2493569|sp|Q50611|PGSA_MYCTU -		synthase	1050
		PUTATIVE CDP-DIACYLGLYCEROL-GLYCEROL-3-PHOSPHATE 3-
		PHOSPHATIDYL-TRANSFERASE
		(PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (PGP
		SYNTHASE)
805	9398464 (7211, 7212)	Novel Protein sim. GBank gi|2493894|sp|Q59966|SRPG_SYNP7 -		synthase	1015
		CYSTEINE SYNTHASE, PLASMID (O-ACETYLSERINE
		SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
806	33202587 (2411, 2412)	Novel Protein sim. GBank gi|2498245|sp|Q51983|CMTG_PSEPU - 4-		synthase	1024
		HYDROXY-2-OXOVALERATE ALDOLASE (HOA)
807	20446202 (8103, 8104)	Novel Protein sim. GBank gi|2501040|sp|O05814|SYP_MYCTU -		synthase	1022
		PROLYL-TRNA SYNTHETASE (PROLINE-TRNA LIGASE) (PRORS)
808	79830747 (1181, 1182)	Novel Protein sim. GBank gi|2582531 (AF026444) - 2-isopropylmalate		synthase	1025, 1036
		synthase [Streptomyces coelicolor]
809	80065038 (1617, 1618)	Novel Protein sim. GBank gi|2582531 (AF026444) - 2-isopropylmalate		synthase	1022, 1024, 1031
		synthase [Streptomyces coelicolor]
810	70949027 (3945, 3946)	Novel Protein sim. GBank gi|2582531 (AF026444) - 2-isopropylmalate		synthase	1026
		synthase [Streptomyces coelicolor]
811	80053048 (2255, 2256)	Novel Protein sim. GBank gi|2661608|emb|CAA15716| - (AL009197)		synthase	1003
		hypothetical ctp synthase [Schizosaccharomyces pombe]
812	80507844 (8917, 8918)	Novel Protein sim. GBank gi|2746079 (AF015310) - BTH1 [Brassica		synthase	1003, 1004, 1010, 1015
		napus]
813	80046498 (7427, 7428)	Novel Protein sim. GBank gi|2791487|emb|CAA16024| - (AL021246) folC		synthase	1002, 1004, 1006, 1015,
		[Mycobacterium tuberculosis]			1024
814	79168037 (6815, 6816)	Novel Protein sim. GBank gi|2829688|sp|P80608|CYSK_MAlZE -		synthase	1028, 1047
		CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-
		ACETYLSERINE (THIOL)-LYASE) (CSASE)
815	78360263 (2257, 2258)	Novel Protein sim. GBank gi|2916867|emb|CAA17615.1| - (AL022004)		synthase	1006
		purM [Mycobacterium tuberculosis]
816	32735522 (7325, 7326)	Novel Protein sim. GBank gi|2924399|emb|CAA12103| - (AJ224731)		synthase	1001
		peptide synthetase [Chroococcus dispersus]
817	27978092 (3551, 3552)	Novel Protein sim. GBank gi|2950419|emb|CAA17864.1| - (AL022076)		synthase	1004
		pks13 [Mycobacterium tuberculosis]
818	20457035 (4371, 4372)	Novel Protein sim. GBank gi|3122391|sp|O33465|METH_PSEPU - 5-		synthase	1008
		METHYLTETRAHYDROFOLATE-HOMOCYSTEINE
		METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
		DEPENDENT ISOZYME) (MS)
819	33206031 (6163, 6164)	Novel Protein sim. GBank gi|3378523|emb|CAA08867| - (AJ009832)		synthase	1004, 1024
		cyclomaltodextrinase glucanotransferase [Thermotoga neapolitana]
820	11073229 (4517, 4518)	Novel Protein sim. GBank gi|3386354 (AF074705) - pyochelin synthetase		synthase	1031
		[Pseudomonas aeruginosa]
821	78787522 (7529, 7530)	Novel Protein sim. GBank gi|3913105|sp|O50468|AROB_NEIGO - 3-		synthase	1020
		DEHYDROQUINATE SYNTHASE
822	78459905 (1775, 1776)	Novel Protein sim. GBank gi|3915158|sp|O06322|TRUA_MYCTU - TRNA		synthase	1024
		PSEUDOURIDINE SYNTHASE A (PSEUDOURIDYLATE SYNTHASE I)
		(PSEUDOURIDINE SYNTHASE I) (URACIL HYDROLYASE)
823	35892891 (8109, 8110)	Novel Protein sim. GBank gi|400182|sp|Q02141|LEU1_LACLA - 2-		synthase	1050
		ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE
		SYNTHASE) (ALPHA-IPM SYNTHETASE)
824	29188808 (8993, 8994)	Novel Protein sim. GBank gi|4467263|emb|CAB37588| - (AL035569)		synthase	1003, 1004, 1020, 1024,
		acetolactate synthase [Streptomyces coelicolor]			1031, 1036, 1055
825	17282497 (5223, 5224)	Novel Protein sim. GBank gi|4521156|dbj|BAA75929.1| - (AB024708)		synthase	1008, 1036
		glutamine 2-oxoglutarate aminotransferase large subunit
		[Corynebacterium glutamicum]
826	80248428 (5475, 5476)	Novel Protein sim. GBank gi|4521156|dbj|BAA75929.1| - (AB024708)		synthase	1004, 1008, 1020, 1021,
		glutamine 2-oxoglutarate aminotransferase large subunit			1022, 1031, 1035
		[Corynebacterium glutamicum]
827	79194674 (2913, 2914)	Novel Protein sim. GBank gi|460064|emb|CAA49847| - (X70397) GMP		synthase	1022
		synthase [Saccharomyces cerevisiae]
828	95201692 (7021, 7022)	Novel Protein sim. GBank gi|461586|sp|Q06185|ATPJ_MOUSE - ATP		synthase	1022, 1035
		SYNTHASE E CHAIN, MITOCHONDRIAL
829	37036243 (6479, 6480)	Novel Protein sim. GBank gi|4633807|gb|AAD26859.1|AF12779 -		synthase	1010
		(AF127795) trehalose biosynthetic enzyme TreY [Rhizobium
		leguminosarum bv. viciae]
830	94647887 (6153, 6154)	Novel Protein sim. GBank gi|536873 (M34549) - POL3 gene product		synthase	1001, 1004, 1006, 1007,
		[Saccharomyces cerevisiae]			1008, 1010, 1015, 1020,
					1021, 1022, 1024, 1027,
					1028, 1031, 1035, 1051
831	86474099 (6545, 6546)	Novel Protein sim. GBank gi|541849|pir||JQ2340 - anthranilate synthase		synthase	1031, 1051
		(EC 4.1.3.27) beta chain - Arabidopsis thaliana
832	79572886 (2509, 2510)	Novel Protein sim. GBank gi|543955|sp|Q05597|CBIP_SALTY -		synthase	1015
		COBYRIC ACID SYNTHASE
833	79473028 (1445, 1446)	Novel Protein sim. GBank gi|547900|sp|Q02251|MCAS_MYCBO -		synthase	1020
		MYCOCEROSIC ACID SYNTHASE
834	29499363 (1559, 1560)	Novel Protein sim. GBank gi|549690|sp|P36087|YKH0_YEAST -		synthase	1007
		HYPOTHETICAL 19.8 KD PROTEIN IN LHS1-NUP100 INTERGENIC
		REGION
835	80503288 (1547, 1548)	Novel Protein sim. GBank gi|585097|sp|P10377|ENTC_ECOLI -		synthase	1002, 1010
		ISOCHORISMATE SYNTHASE ENTC
836	79582160 (2947, 2948)	Novel Protein sim. GBank gi|585763|sp|Q07296|PUR7_STRPN -		synthase	1028
		PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE
		SYNTHASE (SAICAR SYNTHETASE)
837	12891628 (4683, 4684)	Novel Protein sim. GBank gi|628702|pir||S45213 - glutamate-tRNA ligase		synthase	1028
		homolog - Escherichia coli
838	79829998 (699, 700)	Novel Protein sim. GBank gi|728896|sp|P39198|AROC_VIBAN -		synthase	1002
		CHORISMATE SYNTHASE (5-ENOLPYRUVYLSHIKIMATE-3-
		PHOSPHATE PHOSPHOLYASE)
839	29005610 (8539, 8540)	Novel Protein sim. GBank gi|731489|sp|P39965|SYPC_YEAST -		synthase	1002, 1015
		PROBABLE PROLYL-TRNA SYNTHETASE, CYTOPLASMIC (PROLINE-
		TRNA LIGASE) (PRORS)
840	20751472 (221, 222)	Novel Protein sim. GBank gi|731699|sp|P38820|YHR1_YEAST -		synthase	1020, 1022, 1041
		HYPOTHETICAL 49.4 KD PROTEIN IN CDC12-ORC6 INTERGENIC
		REGION
841	78082227 (2943, 2944)	Novel Protein sim. GBank gi|887839 (U28375) - ORF_o182 [Escherichia		synthase	1026
		coli]
842	79606198 (5693, 5694)	Novel Protein sim. GBank gi|135753|sp|P27796|THIK_YEAST - 3-		thiolase	1004, 1020
		KETOACYL-COA THIOLASE PEROXISOMAL PRECURSOR (BETA-
		KETOTHIOLASE) (ACETYL-COA ACYLTRANSFERASE)
		(PEROXISOMAL 3-OXOACYL-COA THIOLASE)
843	9383851 (425, 426)	Novel Protein sim. GBank gi|135762|sp|P13437|THIM_RAT - 3-		thiolase	1015
		KETOACYL-COA THIOLASE MITOCHONDRIAL (BETA-
		KETOTHIOLASE) (ACETYL-COA ACYLTRANSFERASE)
		(MITOCHONDRIAL 3-OXOACYL-COA THIOLASE)
844	70336380 (3653, 3654)	Novel Protein sim. GBank gi|3063884|emb|CAA1 8569| - (AL022486)		thiolase	1007
		putative acetyltransferase [Mycobacterium leprae]
845	17300401 (7049, 7050)	Novel Protein sim. GBank gi|477788|pir||B48376 - beta-		thiolase	1041
		ketothiolase = poly(3-hydroxyalkanoate) synthase - Thiocystis violacea
846	33202597 (5463, 5464)	Novel Protein sim. GBank gi|1617235|emb|CAA69629| - (Y08343)		tm7	1024
		olfactory receptor [Xenopus laevis]
847	87893328 (589, 590)	Novel Protein sim. GBank gi|3289999 (AC005255) - BC85395_1 [Homo		tm7	1023
		sapiens]
848	86474087 (4457, 4458)	Novel Protein sim. GBank gi|4512653|gb|AAD21708.1| - (AC007048)		tnfreceptor	1051
		unknown protein [Arabidopsis thaliana]
849	25258728 (2465, 2466)	Novel Protein sim. GBank gi|4759086|ref|NP_004883.1|pSEC2 - vesicle		traffic	1002, 1024
		trafficking protein sec22b
850	80502259 (2775, 2776)	Novel Protein sim. GBank gi|586350|sp|P38151|YB83_YEAST -	Contains protein domain	transcriptfactor	1002, 1004, 1006, 1010,
		HYPOTHETICAL 45.8 KD PROTEIN IN PCS60-ABD1 INTERGENIC	(PF00013) - KH domain		1015, 1023, 1036, 1041
		REGION
851	80043835 (1919, 1920)	Novel Protein sim. GBank gi|115157|sp|P16574|BVGA_BORPE -	Contains protein domain	transcriptfactor	1015, 1020, 1031
		VIRULENCE FACTORS PUTATIVE POSITIVE TRANSCRIPTION	(PF00072) - Response regulator
		REGULATOR BVGA	receiver domain
852	95198193 (5939, 5940)	Novel Protein sim. GBank gi|4218542|emb|CAA09631.1| - (AJ011500)	Contains protein domain	transcriptfactor	1001, 1004, 1010, 1015,
		putative two-component response regulator [Streptomyces violaceoruber]	(PF00072) - Response regulator		1019, 1035
			receiver domain
853	86668923 (8195, 8196)	Novel Protein sim. GBank gi|2501714|sp|Q61967|ZF90_MOUSE - ZINC	Contains protein domain	transcriptfactor	1006, 1024, 1035, 1039
		FINGER PROTEIN ZFP-90 (ZINC FINGER PROTEIN NK10)	(PF00096) - Zinc finger, C2H2
			type
854	80438888 (4761, 4762)	Novel Protein sim. GBank gi|538413 (L36315) - zinc finger protein [Mus	Contains protein domain	transcriptfactor	1035
		musculus]	(PF00096) - Zinc finger, C2H2
			type
855	95294772 (675, 676)	Novel Protein sim. GBank gi|4507081|ref|NP_003066.1|pSMAR -	Contains protein domain	transcriptfactor	1022
		SWI/SNF related, matrix associated, actin dependent regulator of	(PF00249) - Myb-like DNA-
		chromatin, subfamily c, member 2	binding domain
856	38923775 (1681, 1682)	Novel Protein sim. GBank gi|1170943|sp|P45128|MFD_HAEIN -	Contains protein domain	transcriptfactor	1006, 1020, 1036
		TRANSCRIPTION-REPAIR COUPLING FACTOR (TRCF)	(PF00271) - Helicases conserved
			C-terminal domain
857	79618896 (7835, 7836)	Novel Protein sim. GBank gi|2131747|pir||S64835 - hypothetical protein	Contains protein domain	transcriptfactor	1004, 1015, 1036
		YLR013w - yeast (Saccharomyces cerevisiae)	(PF00320) - GATA zinc finger
858	78459290 (8247, 8248)	Novel Protein sim. GBank gi|130805|sp|P20053|PR04_YEAST - U4/U6	Contains protein domain	transcriptfactor	1024
		SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4	(PF00400) - WD domain, G-beta
			repeat
859	20292176 (2543, 2544)	Novel Protein sim. GBank gi|1353001|sp|P47025|YJL2_YEAST -	Contains protein domain	transcriptfactor	1031
		HYPOTHETICAL 80.0 KD TRP-ASP REPEATS CONTAINING PROTEIN	(PF00400) - WD domain, G-beta
		IN ASF1-CCT7 INTERGENIC REGION	repeat
860	78782931 (643, 644)	Novel Protein sim. GBank gi|416288|dbj|BAA03957| - (D16506) ORF1	Contains protein domain	transcriptfactor	1020, 1036
		[Saccharomyces cerevisiae]	(PF00400) - WD domain, G-beta
			repeat
861	79876409 (8359, 8360)	Novel Protein sim. GBank gi|128183|sp|P11633|NHPB_YEAST -	Contains protein domain	transcriptfactor	1003, 1015, 1020
		NONHISTONE CHROMOSOMAL PROTEIN 6B	(PF00505) - HMG (high mobility
			group) box
862	36623022 (4819, 4820)	Novel Protein sim. GBank gi|548719|sp|Q04863|RELB_MOUSE -	Contains protein domain	transcriptfactor	1031
		TRANSCRIPTION FACTOR RELB	(PF00554) - Rel homology
			domain (RHD).
863	98753100 (201, 202)	Novel Protein sim. GBank gi|107909|pir||JC1235 - transcription factor		transcriptfactor	1055
		BTF3a - human
864	39562855 (5267, 5268)	Novel Protein sim. GBank gi|114814|sp|P14164|BAF1_YEAST -		transcriptfactor	1004, 1020
		TRANSCRIPTION FACTOR BAF1 (ARS BINDING FACTOR 1) (PROTEIN
		ABF1) (BIDIRECTIONALLY ACTING FACTOR) (SFB-B) (DNA
		REPLICATION ENHANCER-BINDING PROTEIN OBF1)
865	21425075 (855, 856)	Novel Protein sim. GBank gi|128915|sp|P16921|NUSG_ECOLI -		transcriptfactor	1006, 1020
		TRANSCRIPTION ANTITERMINATION PROTEIN NUSG
866	27806915 (2985, 2986)	Novel Protein sim. GBank gi|3914014|sp|P96380|MFD_MYCTU -		transcriptfactor	1020
		TRANSCRIPTION-REPAIR COUPLING FACTOR (TRCF)
867	20457127 (4899, 4900)	Novel Protein sim. GBank gi|3914014|sp|P96380|MFD_MYCTU -		transcriptfactor	1008, 1020, 1031
		TRANSCRIPTION-REPAIR COUPLING FACTOR (TRCF)
868	13526955 (2271, 2272)	Novel Protein sim. GBank gi|416737|sp|P24813|CAD1_YEAST -		transcriptfactor	1022
		TRANSCRIPTION FACTOR CAD1 (YAP-2 PROTEIN)
869	29246127 (5381, 5382)	Novel Protein sim. GBank gi|548394|sp|P36264|NUSG_STACA -		transcriptfactor	1003, 1006, 1014
		TRANSCRIPTION ANTITERMINATION PROTEIN NUSG
870	80234879 (2501, 2502)	Novel Protein sim. GBank gi|549671 |sp|P36093|PHD1_YEAST -		transcriptfactor	1002, 1003, 1025
		PUTATIVE TRANSCRIPTION FACTOR PHD1
871	78674899 (7025, 7026)	Novel Protein sim. GBank gi|606946 (U13878) - neural-restrictive silencer		transcriptfactor	1015
		factor [Mus musculus]
872	70948976 (7963, 7964)	Novel Protein sim. GBank gi|1864151 (U88875) - hypoxanthine-guanine	Contains protein domain	transferase	1026
		phosphoribosyl transferase [Mycobacterium avium]	(PF00156) - Phosphoribosyl
			transferase domain
873	39507571 (7337, 7338)	Novel Protein sim. GBank gi|129273|sp|P16964|OTCX_STRPY -	Contains protein domain	transferase	1004
		PROBABLE ORNITHINE CARBAMOYLTRANSFERASE (OTC)	(PF00185) - Aspartate/omithine
			carbamoyltransferase
874	80484113 (6211, 6212)	Novel Protein sim. GBank gi|2764612|emb|CAA04683| - (AJ001330)	Contains protein domain	transferase	1010
		omithine transcarbamoylase [Lactobacillus sakei]	(PF00185) - Aspartate/omithine
			carbamoyltransferase
875	20457620 (1429, 1430)	Novel Protein sim. GBank gi|2052147|emb|CAB08137| - (Z94752) ksgA	Contains protein domain	transferase	1008
		[Mycobacterium tuberculosis]	(PF00398) - Ribosomal RNA
			adenine dimethylases
876	20285868 (2397, 2398)	Novel Protein sim. GBank gi|2052147|emb|CAB08137| - (Z94752) ksgA	Contains protein domain	transferase	1031
		[Mycobacterium tuberculosis]	(PF00398) - Ribosomal RNA
			adenine dimethylases
877	5392182 (7617, 7618)	Novel Protein sim. GBank gi|808857 (M29585) - unknown protein	Contains protein domain	transferase	1055
		[Saccharomyces cerevisiae]	(PF00432) - Prenyltransferase
			and squalene oxidase repeats
878	36997687 (5079, 5080)	Novel Protein sim. GBank gi|135908|sp|P29277|TKT_RHOSH -	Contains protein domain	transferase	1001
		TRANSKETOLASE (TK)	(PF00456) - Transketolase
879	11689874 (1605, 1606)	Novel Protein sim. GBank gi|2984067 (AE000755) - transketolase	Contains protein domain	transferase	1028
		[Aquifex aeolicus]	(PF00456) - Transketolase
880	80217795 (8027, 8028)	Novel Protein sim. GBank gi|464894|sp|P33315|TKT2_YEAST -	Contains protein domain	transferase	1004, 1008, 1020, 1022,
		TRANSKETOLASE 2 (TK 2)	(PF00456) - Transketolase		1031
881	39444044 (8085, 8086)	Novel Protein sim. GBank gi|2137763|pir||JC4958 - serine	Contains protein domain	transferase	1003
		hydroxymethyltransferase (EC 2.1.2.—) 1 - mouse	(PF00464) - Serine
			hydroxymethyltransferase
882	32191727 (5047, 5048)	Novel Protein sim. GBank gi|462189|sp|P34895|GLYA_HYPME - SERINE	Contains protein domain	transferase	1021
		HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)	(PF00464) - Serine
			hydroxymethyltransferase
883	30790797 (5799, 5800)	Novel Protein sim. GBank gi|1001478|dbj|BAA10104| - (D63999)	Contains protein domain	transferase	1002
		hypothetical protein [Synechocystis sp.]	(PF00534) - Glycosyl transferases
			group 1
884	80496423 (7013, 7014)	Novel Protein sim. GBank gi|4981142|gb|AAD35706.1|AE00173 -	Contains protein domain	transferase	1004, 1010, 1031
		(AE001736) lipopolysaccharide biosynthesis protein, putative	(PF00534) - Glycosyl transferases
		[Thermotoga maritima]	group 1
885	87453436 (8039, 8040)	Novel Protein sim. GBank gi|2078350 (U95923) - transaldolase [Solanum	Contains protein domain	transferase	1023
		tuberosum]	(PF00923) - Transaldolase
886	95292599 (1939, 1940)	Novel Protein sim. GBank gi|2995299|emb|CAA18328| - (AL022268)	Contains protein domain	transferase	1003, 1004, 1008, 1014,
		putative tRNA delta(2)-isopentenylpyrophosphate transferase	(PF01715) - IPP transferase		1020, 1021, 1022, 1023,
		[Streptomyces coelicolor]			1031, 1038, 1051
887	86477759 (2921, 2922)	Novel Protein sim. GBank gi|1169910|sp|P45177|GLGB_HAEIN - 1,4-		transferase	1017
		ALPHA-GLUCAN BRANCHING ENZYME (GLYCOGEN BRANCHING
		ENZYME)
888	80430807 (1017, 1018)	Novel Protein sim. GBank gi|1171637|sp|P43619|NADC_YEAST -		transferase	1003, 1004, 1006, 1008,
		PUTATIVE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE			1010, 1020, 1022, 1027,
		(CARBOXYLATING) (QUINOLINATE			1031, 1035, 1041
		PHOSPHORIBOSYLTRANSFERASE (DECARBOXYLATING))
		(QAPRTASE)
889	50843641 (2313, 2314)	Novel Protein sim. GBank gi|117289|sp|P18886|CPT2_RAT -		transferase	1033
		MITOCHONDRIAL CARNITINE O-PALMITOYLTRANSFERASE II
		PRECURSOR (CPT II)
890	24128661 (4113, 4114)	Novel Protein sim. GBank gi|121741|sp|P08011|GTMI_RAT -		transferase	1050
		GLUTATHIONE S-TRANSFERASE, MICROSOMAL
891	80219043 (3121, 3122)	Novel Protein sim. GBank gi|1352650|sp|P48439|OSTG_YEAST -		transferase	1002, 1003, 1004, 1006,
		DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE-PROTEIN			1015, 1020, 1031, 1036
		GLYCOSYLTRANSFERASE GAMMA SUBUNIT PRECURSOR
		(OLIGOSACCHARYL TRANSFERASE GAMMA SUBUNIT)
		(OLIGOSACCHARYL TRANSFERASE 34 KD SUBUNIT)
892	13525870 (4797, 4798)	Novel Protein sim. GBank gi|1929426|emb|CAA69124| - (Y07788)		transferase	1025
		ORF35x7 [Vibrio cholerae]
893	79613528 (3881, 3882)	Novel Protein sim. GBank gi|2290999 (AF006000) - unknown [Bordetella		transferase	1002
		pertussis]
894	80062512 (5871, 5872)	Novel Protein sim. GBank gi|232167|sp|P30537|GLGB_BACCL - 1,4-		transferase	1008
		ALPHA-GLUCAN BRANCHING ENZYME (GLYCOGEN BRANCHING
		ENZYME)
895	80240791 (6127, 6128)	Novel Protein sim. GBank gi|2808801|emb|CAA04602.1| - (AJ001205)		transferase	1014, 1020
		pep2 [Streptomyces coelicolor]
896	17942321 (1963, 1964)	Novel Protein sim. GBank gi|3128321 (AF010496) - nicotinate-nucleotide-		transferase	1036
		dimethylbenzimidazole phosphoribosyltransferase [Rhodobacter
		capsulatus]
897	20438324 (3475, 3476)	Novel Protein sim. GBank gi|417329|sp|P33038|MURA_ENTCL - UDP-N-		transferase	1022
		ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
		(ENOYLPYRUVATE TRANSFERASE) (UDP-N-ACETYLGLUCOSAMINE
		(ENOLPYRUVYL TRANSFERASE) (EPT)
898	20724532 (595, 596)	Novel Protein sim. GBank gi|421646|pir||S34218 - 1,4-alpha-glucan		transferase	1004
		branching enzyme (EC 2.4.1.18) - Streptomyces coelicolor
899	86671251 (3403, 3404)	Novel Protein sim. GBank gi|4850383|gb|AAD31053.1|AC00735 -		transferase	1005
		(AC007357) Contains similarity to gi|4417304 F15O11.7 putative beta-1,4-
		mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase from
		Arabidopsis thaliana BAC gb|AC006446.
900	79421170 (6037, 6038)	Novel Protein sim. GBank gi|4981038|gb|AAD35610.1|AE00172 -		transferase	1004
		(AE001728) tRNA delta-2-isopentenylpyrophosphate transferase
		[Thermotoga maritima]
901	79827474 (3925, 3926)	Novel Protein sim. GBank gi|2340075|gb|AAB67299.1| - (U59485) AttE	Contains protein domain	transport	1041
		[Agrobacterium tumefaciens]	(PF00005) - ABC transporter
902	86465157 (7803, 7804)	Novel Protein sim. GBank gi|3128283 (AF010496) - iron(iii) dicitrate	Contains protein domain	transport	1002, 1004, 1008, 1020,
		transport ATP-binding protein [Rhodobacter capsulatus]	(PF00005) - ABC transporter		1026, 1027
903	78406956 (2421, 2422)	Novel Protein sim. GBank gi|4001826 (AF063016) - G protein-coupled	Contains protein domain	transport	1004
		receptor kinase GRK7 [Spermophilus tridecemlineatus]	(PF00069) - Eukaryotic protein
			kinase domain
904	25323825 (597, 598)	Novel Protein sim. GBank gi|114301|sp|P13586|ATC1_YEAST -	Contains protein domain	transport	1002
		CALCIUM-TRANSPORTING ATPASE 1 (GOLGI CA2+-ATPASE)	(PF00122) - E1-E2 ATPase
905	80543836 (8851, 8852)	Novel Protein sim. GBank gi|114301|sp|P13586|ATC1_YEAST -	Contains protein domain	transport	1041, 1055
		CALCIUM-TRANSPORTING ATPASE 1 (GOLGI CA2+-ATPASE)	(PF00122) - E1-E2 ATPase
906	39434986 (6081, 6082)	Novel Protein sim. GBank gi|114302|sp|P13587|ATN1_YEAST - SODIUM	Contains protein domain	transport	1004
		TRANSPORT ATPASE 1	(PF00122) - E1-E2 ATPase
907	13086008 (9021, 9022)	Novel Protein sim. GBank gi|1353678 (U42410) - heavy-metal	Contains protein domain	transport	1025
		transporting P-type ATPase [Proteus mirabilis]	(PF00122) - E1-E2 ATPase
908	30673742 (741, 742)	Novel Protein sim. GBank gi|1731256|sp|Q10866|YW27_MYCTU -	Contains protein domain	transport	1006
		PROBABLE CATION-TRANSPORTING ATPASE CY39.27	(PF00122) - E1-E2 ATPase
909	17121073 (2925, 2926)	Novel Protein sim. GBank gi|728935|sp|P38995|ATU2_YEAST -	Contains protein domain	transport	1036
		PROBABLE COPPER-TRANSPORTING ATPASE (CU2+-ATPASE)	(PF00122) - E1-E2 ATPase
910	23303892 (8623, 8624)	Novel Protein sim. GBank gi|1175298|sp|P44849|Y736_HAEIN -	Contains protein domain	transport	1035
		HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER HI0736	(PF00209) -
			Sodium: neurotransmitter
			symporter family
911	90937131 (4161, 4162)	Novel Protein sim. GBank gi|3347922 (AF075262) - orphan transporter	Contains protein domain	transport	1018
		isoform A12 [Mus musculus]	(PF00209) -
			Sodium: neurotransmitter
			symporter family
912	90935315 (4493, 4494)	Novel Protein sim. GBank gi|3347922 (AF075262) - orphan transporter	Contains protein domain	transport	1017, 1018, 1051
		isoform A12 [Mus musculus]	(PF00209) -
			Sodium: neurotransmitter
			symporter family
913	78996347 (5607, 5608)	Novel Protein sim. GBank gi|131515|sp|P02908|PTGA_SALTY - PTS	Contains protein domain	transport	1001
		SYSTEM, GLUCOSE-SPECIFIC IIA COMPONENT (EIIA-GLC)	(PF00358) - phosphoenolpyruvate
		(GLUCOSE-PERMEASE IIA COMPONENT) (PHOSPHOTRANSFERASE	dependent sugar
		ENZYME II, A COMPONENT) (EIII-GLC)	phosphotransferase system, EIIA 1
914	65487496 (8841, 8842)	Novel Protein sim. GBank gi|585754|sp|P24217|PTFA_ECOLI - PTS	Contains protein domain	transport	1021
		SYSTEM, FRUCTOSE-SPECIFIC IIA/FPR COMPONENT (EIIA-FRU)	(PF00359) - phosphoenolpyruvate
		(FRUCTOSE-PERMEASE IIA/FPR COMPONENT)	dependent sugar
		(PHOSPHOTRANSFERASE ENZYME II, A/FPR COMPONENT)	phosphotransferase system, EIIA 2
		(PHOSPHOTRANSFERASE FPR PROTEIN) (PSEUDO-HPR) (EIII-FRU)
		(FRUCTOSE PTS DIPHO . . .
915	10194015 (5935, 5936)	Novel Protein sim. GBank gi|118906|sp|P23847|DPPA_ECOLI -	Contains protein domain	transport	1002
		PERIPLASMIC DIPEPTIDE TRANSPORT PROTEIN PRECURSOR	(PF00496) - Bacterial extracellular
		(DIPEPTIDE-BINDING PROTEIN) (DBP)	solute-binding proteins, family 5
916	78468887 (5353, 5354)	Novel Protein sim. GBank gi|1827807|pdb|1DPE| - Dipeptide-Binding	Contains protein domain	transport	1024
		Protein	(PF00496) - Bacterial extracellular
			solute-binding proteins, family 5
917	80055575 (2185, 2186)	Novel Protein sim. GBank gi|2960090|emb|CAA17988.1| - (AL022121)	Contains protein domain	transport	1003
		dppA [Mycobacterium tuberculosis]	(PF00496) - Bacterial extracellular
			solute-binding proteins, family 5
918	10879734 (1841, 1842)	Novel Protein sim. GBank gi|400831|sp|P31135|POTH_ECOLI -	Contains protein domain	transport	1022
		PUTRESCINE TRANSPORT SYSTEM PERMEASE PROTEIN POTH	(PF00528) - Binding-protein-
			dependent transport systems
			inner membrane component
919	85520849 (1131, 1132)	Novel Protein sim. GBank gi|5458693|emb|CAB50180.1| - (AJ248287)	Contains protein domain	transport	1046
		PAB1535 [Pyrococcus abyssi]	(PF00706) - Anenome neuroloxin
920	11700068 (677, 678)	Novel Protein sim. GBank gi|529013 (U12598) - multidrug resistance	Contains protein domain	transport	1028
		protein [Escherichia coli]	(PF00873) - AcrB/AcrD/AcrF
			family
921	17087174 (3747, 3748)	Novel Protein sim. GBank gi|5031697|ref|NP_005594.1|pFIC1 - familial	Contains protein domain	transport	1021
		intrahepatic cholestasis 1, (progressive, Byler disease and benign	(PF01581) - FMRFamide related
		recurrent)	peptide family
922	20452390 (2267, 2268)	Novel Protein sim. GBank gi|2632049|emb|CAA05608| - (AJ002571)	Contains protein domain	transport	1022
		YkoK [Bacillus subtilis]	(PF01769) - Divalent cation
			transporter
923	10103979 (3641, 3642)	Novel Protein sim. GBank gi|1001500|dbj|BAA10125| - (D64000) high-		transport	1015
		affinity branched-chain amino acid transport ATP-binding protein
		[Synechocystis sp.]
924	11359786 (335, 336)	Novel Protein sim. GBank gi|1019379|dbj|BAA05387| - (D26358) CmpB		transport	1004, 1010
		[Synechococcus sp.]
925	20434142 (5473, 5474)	Novel Protein sim. GBank gi|1073007|pir||S54001 - pyoverdine		transport	1001, 1008
		synthetase E - Pseudomonas aeruginosa
926	10106248 (4789, 4790)	Novel Protein sim. GBank gi|1073439|pir||S47706 - hypothetical protein		transport	1010
		f231 - Escherichia coli
927	17937351 (7315, 7316)	Novel Protein sim. GBank gi|114921|sp|P17447|BETT_ECOLI |HIGH-		transport	1035
		AFFINITY CHOLINE TRANSPORT PROTEIN
928	79793961 (8075, 8076)	Novel Protein sim. GBank gi|115122|sp|P21627|BRAD_PSEAE - HIGH-		transport	1002, 1015
		AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT PROTEIN
		BRAD
929	79565972 (2845, 2846)	Novel Protein sim. GBank gi|116370|sp|P14285|CHRA_PSEAE -		transport	1015
		CHROMATE TRANSPORT PROTEIN
930	16730012 (1585, 1586)	Novel Protein sim. GBank gi|1170991|sp|P45321|MODC_HAEIN -		transport	1036
		MOLYBDENUM TRANSPORT ATP-BINDING PROTEIN MODC
931	85800685 (8989, 8990)	Novel Protein sim. GBank gi|1171029|sp|P44407|MSBA_HAEIN -		transport	1023
		PROBABLE TRANSPORT ATP-BINDING PROTEIN MSBA
932	29358991 (3919, 3920)	Novel Protein sim. GBank gi|1173364|sp|P45380|SAT1_RAT - SULFATE		transport	1020
		ANION TRANSPORTER 1 (CANALICULAR SULFATE TRANSPORTER)
		(SULFATE/CARBONATE ANTIPORTER)
933	80440616 (8793, 8794)	Novel Protein sim. GBank gi|1173421|sp|P43416|SECY_STRSC -		transport	1002, 1003, 1004, 1008,
		PREPROTEIN TRANSLOCASE SECY SUBUNIT			1010, 1031, 1035
934	79247343 (1321, 1322)	Novel Protein sim. GBank gi|1176165|sp|P42613|YHAU_ECOLI -		transport	1036
		HYPOTHETICAL 49.0 KD PROTEIN IN RNPB-SOHA INTERGENIC
		REGION
935	56616185 (6083, 6084)	Novel Protein sim. GBank gi|120593|sp|P11551|FUCP_ECOLI - L -		transport	1020, 1033
		FUCOSE PERMEASE
936	65448630 (8855, 8856)	Novel Protein sim. GBank gi|127339|sp|P27299|MSBA_ECOLI -		transport	1046
		PROBABLE TRANSPORT ATP-BINDING PROTEIN MSBA
937	77601022 (9043, 9044)	Novel Protein sim. GBank gi|130093|sp|P16677|PHNC_ECOLI -		transport	1046
		PHOSPHONATES TRANSPORT ATP-BINDING PROTEIN PHNC
938	19536664 (5351, 5352)	Novel Protein sim. GBank gi|1345859|sp|P49573|CTR1_YEAST -		transport	1020
		COPPER TRANSPORT PROTEIN CTR1 (COPPER TRANSPORTER 1)
939	80063108 (2017, 2018)	Novel Protein sim. GBank gi|1346493|sp|P47186|MAXT_YEAST -		transport	1002, 1006, 1015, 1020,
		PUTATIVE MALTOSE PERMEASE (MALTOSE TRANSPORT PROTEIN)			1022, 1041
940	20481264 (8307, 8308)	Novel Protein sim. GBank gi|1352948|sp|P47185|HXTF_YEAST -		transport	1020, 1055
		HEXOSE TRANSPORTER HXTI6
941	79245587 (8685, 8686)	Novel Protein sim. GBank gi|140681|sp|P03813|YGEA_ECOLI -		transport	1036
		HYPOTHETICAL 25.2 KD PROTEIN IN LYSR-ARAE INTERGENIC
		REGION
942	13523176 (679, 680)	Novel Protein sim. GBank gi|1514530|emb|CAA65825| - (X97187) ABC-C		transport	1022
		transporter [Homo sapiens]
943	70451588 (8693, 8694)	Novel Protein sim. GBank gi|1526981|emb|CAA68204| - (X99945) amino		transport	1021, 1046
		acid permease YeeF like protein [Salmonella typhimurium]
944	80067879 (6901, 6902)	Novel Protein sim. GBank gi|1532204 (U68036) - putative ABC		transport	1020
		transporter intracellular ATPase subunit BldkD [Streptomyces coelicolor]
945	80053078 (8943, 8944)	Novel Protein sim. GBank gi|1651664|dbj|BAA16592| - (D90899) Iron(III)		transport	1003
		dicitrate transport system permease protein FecE [Synechocystis sp.]
946	27803590 (4607, 4608)	Novel Protein sim. GBank gi|1654041|emb|CAB03701| - (Z81360)		transport	1050
		hypothetical protein Rv1739c [Mycobacterium tuberculosis]
947	78770592 (6231, 6232)	Novel Protein sim. GBank gi|1708002|sp|P48813|GNP1_YEAST - HIGH-		transport	1007, 1020, 1024
		AFFINITY GLUTAMINE PERMEASE
948	34083080 (135, 136)	Novel Protein sim. GBank gi|171263 (M88252) - COT1 protein		transport	1000
		[Saccharomyces cerevisiae]
949	95292787 (67, 68)	Novel Protein sim. GBank gi|1723081|sp|Q11046|Y089_MYCTU -		transport	1022
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN
		CY50.09
950	79189803 (137, 138)	Novel Protein sim. GBank gi|1723081|sp|Q11046|Y089_MYCTU -		transport	1025
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN
		CY50.09
951	11422022 (8971, 8972)	Novel Protein sim. GBank gi|1723082|sp|Q11047|Y08A_MYCTU -		transport	1015
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN
		CY50.10
952	10013989 (4219, 4220)	Novel Protein sim. GBank gi|2113938|emb|CAB08923| - (Z95556) fadD35		transport	1021
		[Mycobacterium tuberculosis]
953	20759081 (1381, 1382)	Novel Protein sim. GBank gi|2126200|pir||S54438 - hemin permease -		transport	1020
		Yersinia enterocolitica
954	20552734 (1209, 1210)	Novel Protein sim. GBank gi|2132318|pir||S69476 - hypothetical protein		transport	1055
		YPR202w - yeast (Saccharomyces cerevisiae)
955	28473433 (7449, 7450)	Novel Protein sim. GBank gi|2143756|pir||S68362 - glucose transport		transport	1041
		protein type 2 - rat (fragment)
956	10369659 (8173, 8174)	Novel Protein sim. GBank gi|2144965|pir||QRECFA - iron(lll) dicitrate		transport	1015, 1021
		transport system outer membrane receptor precursor - Escherichia coli
957	47656103(4649, 4650)	Novel Protein sim. GBank gi|2492534|sp|P77327|PROY_ECOLI -		transport	1026
		PROLINE-SPECIFIC PERMEASE PROY
958	79262992 (8035, 8036)	Novel Protein sim. GBank gi|2492558|sp|Q47538|TAUB_ECOLI -		transport	1036
		TAURINE TRANSPORT ATP-BINDING PROTEIN TAUB
959	80473481 (7847, 7848)	Novel Protein sim. GBank gi|2492595|sp|Q53193|Y4TR_RHISN -		transport	1010
		PROBABLE PEPTIDE ABC TRANSPORTER ATP-BINDING PROTEIN
		Y4TR
960	10126820 (939, 940)	Novel Protein sim. GBank gi|2492597|sp|Q55774|Y182_SYNY3 -		transport	1041
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN
		SLL0182
961	80219898 (3135, 3136)	Novel Protein sim. GBank gi|2492606|sp|Q08234|YOH5_YEAST -		transport	1002, 1024, 1031, 1035,
		PROBABLE ATP-DEPENDENT TRANSPORTER YOL075C			1036, 1041
962	10082311 (7463, 7464)	Novel Protein sim. GBank gi|2495513|sp|P77221|YAHG_ECOLI -		transport	1041
		HYPOTHETICAL 50.4 KD PROTEIN IN BETT-PRPR INTERGENIC
		REGION
963	79833887 (7239, 7240)	Novel Protein sim. GBank gi|2501165|sp|Q03263|YM8M_YEAST -		transport	1006, 1023
		HYPOTHETICAL 59.6 KD PROTEIN IN DSK2-CAT8 INTERGENIC
		REGION
964	86474209 (7453, 7454)	Novel Protein sim. GBank gi|2501669|sp|P75892|YCDG_ECOLI -		transport	1006, 1020, 1024, 1026
		HYPOTHETICAL 48.1 KD PROTEIN IN WRBA-PUTA INTERGENIC
		REGION
965	80020242 (6329, 6330)	Novel Protein sim. GBank gi|2506110|sp|P31219|YBBA_ECOLI -		transport	1006, 1007, 1008, 1020
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN YBBA
966	79551943 (5489, 5490)	Novel Protein sim. GBank gi|2507365|sp|P37902|YBEJ_ECOLI - AMINO-		transport	1002, 1036
		ACID ABC TRANSPORTER BINDING PROTEIN IN GLTJ-CUTE
		INTERGENIC REGION PRECURSOR
967	55284087 (6637, 6638)	Novel Protein sim. GBank gi|2584767|emb|CAA03994.1| - (AJ000327)		transport	1050
		adrenoleukodystrophy related protein [Homo sapiens]
968	13525866 (3015, 3016)	Novel Protein sim. GBank gi|2624376|emb|CAA04762| - (AJ001437)		transport	1025
		putative P-type cation-translocating membrane ATPase [Proteus mirabilis]
969	11398575 (8873, 8874)	Novel Protein sim. GBank gi|2633814|emb|CAB13316| - (Z99111) similar		transport	1004
		to ABC transporter (ATP-binding protein) [Bacillus subtillis]
970	80060854 (3601, 3602)	Novel Protein sim. GBank gi|2649950 (AE001058) - glutamine ABC		transport	1003, 1022
		transporter, ATP-binding protein (glnQ) [Archaeoglobus fulgidus]
971	95292975 (8113, 8114)	Novel Protein sim. GBank gi|2649950 (AE001058) - glutamine ABC		transport	1003, 1006, 1008, 1015,
		transporter, ATP-binding protein (glnQ) [Archaeoglobus fulgidus]			1020, 1041
972	55650325 (557, 558)	Novel Protein sim. GBank gi|2650420 (AE001090) - branched-chain		transport	1000, 1001, 1026
		amino acid ABC transporter, ATP-binding protein (braG-1)
		[Archaeoglobus fulgidus]
973	79560269 (3409, 3410)	Novel Protein sim. GBank gi|2661836|emb|CAA75187| - (Y14964)		transport	1035
		putative transport protein [Methylophllus methylotrophus]
974	91013413 (7903, 7904)	Novel Protein sim. GBank gi|2665707|gb|AAB88467| - (AF035413) AgaB		transport	1008, 1036
		[Agrobacterium tumefaciens]
975	55766952 (5543, 5544)	Novel Protein sim. GBank gi|2695825|emb|CAA15895| - (AL021006) corA		transport	1004, 1051
		[Mycobacterium tuberculosis]
976	20293885 (2325, 2326)	Novel Protein sim. GBank gi|2695836|emb|CAA15906| - (AL021006)		transport	1031
		hypothetical protein Rv1250 [Mycobacterium tuberculosis]
977	80499399 (3303, 3304)	Novel Protein sim. GBank gi|2791517|emb|CAA16054| - (AL021246)		transport	1004, 1008, 1010, 1020,
		hypothetical protein Rv2477c [Mycobacterium tuberculosis]			1021, 1031, 1041
978	77887171 (8679, 8680)	Novel Protein sim. GBank gi|2791517|emb|CAA16054| - (AL021246)		transport	1019
		hypothetical protein Rv2477c [Mycobacterium tuberculosis]
979	79629161 (1297, 1298)	Novel Protein sim. GBank gi|290801|gb|AAD152371| - (L17003) member of		transport	1036
		super-family of ABC protein [Frencisella tularensis (var. novicida)]
980	70514622 (8339, 8340)	Novel Protein sim. GBank gi|3128315 (AF010496) - potential secretion		transport	1007
		ATP - binding protein [Rhodobacter capsulatus]
981	77579839 (8421, 8422)	Novel Protein sim. GBank gi|3218373|emb|CAA19625| - (AL023862) ABC		transport	1007, 1008
		transporter ATP binding protein [Streptomyces coelicolor]
982	5602936 (6455, 6456)	Novel Protein sim. GBank gi|3402246|emb|CAA20182| - (AL031184)		transport	1055
		oligopeptide ABC transporter ATP-binding protein [Streptomyces
		coelicolor]
983	79644200 (6537, 6538)	Novel Protein sim. GBank gi|3483045|emb|CAA20556| - (AL031371)		transport	1035
		putative transport system permease protein [Streptomyces coelicolor]
984	88097234 (8909, 8910)	Novel Protein sim. GBank gi|3582213 (AE001272) - Potential ABC		transport	1016
		transporter [Lactococcus lactis]
985	35106817 (6357, 6358)	Novel Protein sim. GBank gi|3913092|sp|Q46170|ARCD_CLOPE -		transport	1004, 1015, 1020, 1024
		ARGININE/ORNITHINE ANTIPORTER
986	80062914 (6045, 6046)	Novel Protein sim. GBank gi|3915963|sp|P32386|YBT1_YEAST - ATP-		transport	1008, 1015
		DEPENDENT BILE ACID PERMEASE
987	11818289 (3461, 3462)	Novel Protein sim. GBank gi|4007737|emb|CAA22421| - (AL034447)		transport	1004
		putative sugar transporter [Streptomyces coelicolor]
988	79859550 (3639, 3640)	Novel Protein sim. GBank gi|400961|sp|P04982|RBSD_ECOLI - HIGH		transport	1015, 1024
		AFFINITY RIBOSE TRANSPORT PROTEIN RBSD
989	79830774 (7999, 8000)	Novel Protein sim. GBank gi|409547 (L07492) - sugar transport protein		transport	1021
		[Saccharomyces cerevisiae]
990	78951434 (7149, 7150)	Novel Protein sim. GBank gi|4240130|dbj|BAA74845.1| - (AB020629)		transport	1041
		KIAA0822 protein [Homo sapiens]
991	20288787 (347, 348)	Novel Protein sim. GBank gi|4584481|emb|CAB40684.1| - (AL049587)		transport	1020
		putative L-asparagine permease [Streptomyces coelicolor]
992	78378350 (5605, 5606)	Novel Protein sim. GBank gi|4584481|emb|CAB40684.1| - (AL049587)		transport	1006, 1024
		putative L-asparagine permease [Streptomyces coelicolor]
993	11397491 (5343, 5344)	Novel Protein sim. GBank gi|4928292|gb|AAD33527.1|AF13211 -		transport	1003
		(AF132117) FhuA [Staphylococcus aureus]
994	11686972 (3233, 3234)	Novel Protein sim. GBank gi|4981111|gb|AAD35677.1|AE00173 -		transport	1028
		(AE001734) amino acid ABC transporter, permease protein [Thermotoga
		maritima]
995	65478887 (571, 572)	Novel Protein sim. GBank gi|5354185|gb|AAD42394.1|AF15749 -		transport	1014
		(AF157493) hypothetical ABC transporter ATP-binding protein
		[Zymomonas mobilis]
996	70945398 (4025, 4026)	Novel Protein sim. GBank gi|5441754|emb|CAB46778.1| - (AL096811)		transport	1026
		putative gluconate permease [Streptomyces coelicolor A3(2)]
997	94646492 (6023, 6024)	Novel Protein sim. GBank gi|5456701|gb|AAD43626.1|AF07141 -		transport	1028
		(AF071411) multidrug resistance protein MDR [Emericella nidulans]
998	79317345 (6835, 6836)	Novel Protein sim. GBank gi|5457576|emb|CAB49067.1| - (AJ248283)		transport	1002, 1020
		PAB0092 [Pyrococcus abyssi]
999	80420613 (4809, 4810)	Novel Protein sim. GBank gi|5459396|emb|CAB50754.1| - (AL096839)		transport	1003, 1004, 1008, 1015,
		putative integral membrane transport protein [Streptomyces coelicolor]			1020, 1021, 1023, 1024,
					1031, 1036
1000	79921598 (681, 682)	Novel Protein sim. GBank gi|558389|emb|CAA86236| - (Z38113) len: 888,		transport	1001
		CAI: 0.19 incomplete orf similar to SNQ2_YEAST P32568 SNQ2
		PROTEIN [Saccharomyces cerevisiae]
1001	10332112 (7097, 7098)	Novel Protein sim. GBank gi|585410|sp|P22730|LIVG_ECOLI - HIGH-		transport	1002
		AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-
		BINDING PROTEIN LIVG (LIV-I PROTEIN G)
1002	79970000 (7393, 7394)	Novel Protein sim. GBank gi|585957|sp|P38377|S61A_CANFA -		transport	1031, 1047
		PROTEIN TRANSPORT PROTEIN SEC61 ALPHA SUBUNIT
1003	78760805 (5633, 5634)	Novel Protein sim. GBank gi|586361|sp|P38358|YB8G_YEAST -		transport	1014, 1036, 1041
		HYPOTHETICAL 51.7 KD PROTEIN IN CTP1-SUL2 INTERGENIC
		REGION
1004	80219743 (7581, 7582)	Novel Protein sim. GBank gi|586361|sp|P38358|YB8G_YEAST -		transport	1001, 1003, 1004, 1006,
		HYPOTHETICAL 51.7 KD PROTEIN IN CTP1-SUL2 INTERGENIC			1020, 1028, 1031
		REGION
1005	54534688 (5357, 5358)	Novel Protein sim. GBank gi|586685|sp|P37643|YHJE_ECOLI -		transport	1038
		HYPOTHETICAL METABOLITE TRANSPORT PROTEIN IN TREF-KDGK
		INTERGENIC REGION (O440)
1006	71088508 (169, 170)	Novel Protein sim. GBank gi|606163 (U18997) - ORF_1506 [Escherichia		transport	1026, 1050
		coli]
1007	77504621 (8303, 8304)	Novel Protein sim. GBank gi|628013|pir||A54892 - Na+-dependent		transport	1014
		nucleoside transport protein cNT1 - rat
1008	27981977 (4865, 4866)	Novel Protein sim. GBank gi|729606|sp|P41076|GLTL_ECOLI -		transport	1050
		GLUTAMATE/ASPARTATE TRANSPORT ATP-BINDING PROTEIN GLTL
1009	27827777 (5989, 5990)	Novel Protein sim. GBank gi|731347|sp|P39109|YCF1_YEAST - METAL		transport	1022
		RESISTANCE PROTEIN YCF1 (YEAST CADMIUM FACTOR 1)
1010	80029924 (8097, 8098)	Novel Protein sim. GBank gi|731415|sp|P39986|ATC6_YEAST -		transport	1003, 1004, 1020, 1028,
		PROBABLE CALCIUM-TRANSPORTING ATPASE 6			1031, 1041
1011	78791424 (505, 506)	Novel Protein sim. GBank gi|731687|sp|P38809|YHP7_YEAST -		transport	1020
		HYPOTHETICAL 40.7 KD PROTEIN IN HXT5-NRK1 INTERGENIC
		REGION
1012	17661691 (4543, 4544)	Novel Protein sim. GBank gi|731689|sp|P38811|YHP9_YEAST -		transport	1041
		HYPOTHETICAL 433.2 KD PROTEIN IN HXT5-NRK1 INTERGENIC
		REGION
1013	80238737 (6063, 6064)	Novel Protein sim. GBank gi|731689|sp|P38811|YHP9_YEAST -		transport	1002, 1004, 1008, 1024,
		HYPOTHETICAL 433.2 KD PROTEIN IN HXT5-NRK1 INTERGENIC			1031
		REGION
1014	32119870 (6109, 6110)	Novel Protein sim. GBank gi|77980|pir||B33586 - C4-dicarboxylate		transport	1041
		transport system regulatory protein DctB - Rhizobium melilotl
1015	11397943 (7161, 7162)	Novel Protein sim. GBank gi|83036|pir||A31928 - glucose transport		transport	1020
		protein, high affinity - yeast [Saccharomyces cerevisiae]
1016	79263011 (3423, 3424)	Novel Protein sim. GBank gi|95819|pir||S16298 - ferric enterobactin		transport	1002, 1036
		transport protein fepC - Escherichia coli
1017	38036706 (1457, 1458)			transport	1022, 1031
1018	80080600 (4197, 4198)	Novel Protein sim. GBank gi|135419|sp|P09734|TBA3_YEAST - TUBULIN		tubulin	1031
		ALPHA-3 CHAIN
1019	80234579 (3165, 3166)	Novel Protein sim. GBank gi|1729859|sp|P53378|TBG_YEAST -		tubulin	1004, 1015, 1020
		TUBULIN GAMMA CHAIN
1020	11360183 (7501, 7502)	Novel Protein sim. GBank gi|4139493|pdb|1BT0| - Rub1	Contains protein domain	ubiquitin	1004
			(PF00240) - Ubiquitin family
1021	35104003 (4679, 4680)	Novel Protein sim. GBank gi|3800760 (AF064248) - ubiquitin specific	Contains protein domain	ubiquitin	1047
		protease 46 [Gallus gallus]	(PF00442) - Ubiquitin carboxyl-
			terminal hydrolases family 2
1022	28351078 (7135, 7136)	Novel Protein sim. GBank gi|136684|sp|P19812|UBR1_YEAST - N-END-		ubiquitin	1006, 1035
		RECOGNIZING PROTEIN (UBIQUITIN-PROTEIN LIGASE E3
		COMPONENT) (N-RECOGNIN)
1023	98964873 (3363, 3364)	Novel Protein sim. GBank gi|1717965|sp|P54860|UFD2_YEAST -		ubiquitin	1001, 1002, 1003, 1004,
		UBIQUITIN FUSION DEGRADATION PROTEIN 2 (UB FUSION PROTEIN			1006, 1008, 1010, 1020,
		2)			1022, 1025, 1031, 1035,
					1036, 1041
1024	79569225 (1385, 1386)	Novel Protein sim. GBank gi|3334400|sp|Q24574|UBPE_DROME -		ubiquitin	1031
		UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 64E (UBIQUITIN
		THIOLESTERASE 64E) (UBIQUITIN-SPECIFIC PROCESSING
		PROTEASE 64E) (DEUBIQUITINATING ENZYME 64E)
1025	80217599 (5243, 5244)	Novel Protein sim. GBank gi|586433|sp|P38187|UBPD_YEAST -		ubiqudin	1004, 1020, 1022, 1024,
		UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (UBIQUITIN			1041
		THIOLESTERASE 13) (UBIQUITIN-SPECIFIC PROCESSING
		PROTEASE 13) (DEUBIQUITINATING ENZYME 13)
1026	80231869 (399, 400)	Novel Protein sim. GBank gi|731042|sp|P39944|UBP5_YEAST -		ubiquitin	1003, 1006, 1008, 1015,
		UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 5 (UBIQUITIN			1020, 1021, 1024, 1031
		THIOLESTERASE 5) (UBIQUITIN-SPECIFIC PROCESSING PROTEASE
		5) (DEUBIQUITINATING ENZYME 5)
1027	86473844 (2999, 3000)	Novel Protein sim. GBank gi|4768911|gb|AAD29676.1|AF13120 -	Contains protein domain	water_channel	1002, 1010, 1026, 1051,
		(AF131201) plasma membrane MIP protein [Zea mays]	(PF00230) - Major intrinsic protein		1055
1028	39587959 (77, 78)	Novel Protein sim. GBank gi|1176900|sp|Q09665|YS57_CAEEL -	Contains protein domain	UNCLASSIFIED	1022
		HYPOTHETICAL CALCIUM-BINDING PROTEIN ZK673.7 IN	(PF00036) - EF hand
		CHROMOSOME II
1029	57447926 (8409, 8410)	Novel Protein sim. GBank gi|2506252|sp|P12815|ALG2_MOUSE -	Contains protein domain	UNCLASSIFIED	1055
		PROBABLE CALCIUM-BINDING PROTEIN ALG-2 (PMP41) (ALG-257)	(PF00036) - EF hand
1030	80586402 (2773, 2774)	Novel Protein sim. GBank gi|119810|sp|P02692|FABL_RAT - FATTY	Contains protein domain	UNCLASSIFIED	1006, 1014, 1055
		ACID-BINDING PROTEIN, LIVER (L-FABP) (Z-PROTEIN) (SQUALENE-	(PF00061) - lipocalin
		AND STEROL-CARRIER PROTEIN) (SCP) (P14)
1031	11101997 (397, 398)	Novel Protein sim. GBank gi|1621285 (U64519) - CheAY [Rhodospirillum	Contains protein domain	UNCLASSIFIED	1004
		centenum]	(PF00072) - Response regulator
			receiver domain
1032	20440722 (8721, 8722)	Novel Protein sim. GBank gi|5457253|emb|CAB46941.1| - (AL096822)	Contains protein domain	UNCLASSIFIED	1022
		putative two-component system response transcriptional regulator	(PF00072) - Response regulator
		[Streptomyces coelicolor]	receiver domain
1033	80499566 (2105, 2106)	Novel Protein sim. GBank gi|464776|sp|P80293|SODM_PROFR -	Contains protein domain	UNCLASSIFIED	1004, 1010, 1026
		SUPEROXIDE DISMUTASE (MN-FE)	(PF00081) - iron/manganese
			superoxide dismutases (SODM)
1034	20189728 (5805, 5806)	Novel Protein sim. GBank gi|4156104 (AE001569) - putative Outer	Contains protein domain	UNCLASSIFIED	1022
		membrane protein [Helicobacter pylori J99]	(PF00098) - Zinc finger, C2H2
			type
1035	30402847 (2487, 2488)		Contains protein domain	UNCLASSIFIED	1024
			(PF00096) - Zinc finger, C2H2
			type
1036	54533415 (7041, 7042)		Contains protein domain	UNCLASSIFIED	1038
			(PF00103) - Somatotropin
			hormone family
1037	80020711 (6965, 6966)	Novel Protein sim. GBank gi|121383|sp|P19904|GLNA_VIBAL -	Contains protein domain	UNCLASSIFIED	1004, 1020, 1022
		GLUTAMINE SYNTHETASE (GLUTAMATE-AMMONIA LIGASE)	(PF00120) - Glutamine
			synthetase
1038	85527155 (373, 374)	Novel Protein sim. GBank gi|1707958|sp|Q10378|GLN2_MYCTU -	Contains protein domain	UNCLASSIFIED	1035
		PROBABLE GLUTAMINE SYNTHETASE 2 (GLUTAMATE-AMMONIA	(PF00120) - Glutamine
		LIGASE 2)	synthetase
1039	79817849 (7333, 7334)	Novel Protein sim. GBank gi|3183245|sp|P78061|YCJK_ECOLI -	Contains protein domain	UNCLASSIFIED	1015
		PUTATIVE GLUTAMINE SYNTHETASE (GLUTAMATE-AMMONIA	(PF00120) - Glutamine
		LIGASE)	synthetase
1040	82300051 (861, 862)	Novel Protein sim. GBank gi|127420|sp|P19888|MTBA_BACAR -	Contains protein domain	UNCLASSIFIED	1001, 1002, 1003, 1004,
		MODIFICATION METHYLASE BANI (CYTOSINE-SPECIFIC	(PF00145) - C-5 cytosine-specific		1006, 1007, 1008, 1014,
		METHYLTRANSFERASE BANI) (M.BANI)	DNA methylase		1015, 1020, 1021, 1022,
					1023,1024, 1026, 1031,
					1035, 1036, 1041, 1055
1041	78383654 (6941, 6942)	Novel Protein sim. GBank gi|3876012|emb|CAA90761| - (Z50873)	Contains protein domain	UNCLASSIFIED	1002
		Similarity to N.crassa ADP/ATP carrier protein (SW: ADT_NEUCR)	(PF00153) - Mitochondrial carrier
		[Caenorhabditis elegans]	proteins
1042	36997517 (8895, 8896)	Novel Protein sim. GBank gi|1346014|sp|P17899|FLBD_CAUCR -	Contains protein domain	UNCLASSIFIED	1001
		TRANSCRIPTIONAL REGULATORY PROTEIN FLBD	(PF00158) - Sigma-54
			transcription factors
1043	82062100 (1683, 1684)	Novel Protein sim. GBank gi|2501738|sp|Q06639|YD03_YEAST -	Contains protein domain	UNCLASSIFIED	1002, 1003, 1004, 1010,
		PUTATIVE 101.7 KD TRANSCRIPTIONAL REGULATORY PROTEIN IN	(PF00172) - Fungal Zn(2)-Cys(6)		1014, 1020, 1022
		PRO1-CPR5 INTERGENIC REGION	binuclear cluster domain
1044	77912099 (2459, 2460)		Contains protein domain	UNCLASSIFIED	1014, 1033
			(PF00185) - Aspartate/omithine
			carbamoyltransferase
1045	79600852 (1363, 1364)	Novel Protein sim. GBank gi|2506199|sp|P25739|PUR8_ECOLI -	Contains protein domain	UNCLASSIFIED	1020, 1031
		ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)	(PF00206) - Lyase
1046	15017854 (5505, 5506)	Novel Protein sim. GBank gi|18358|sp|P25971|DCOP_BACSU -	Contains protein domain	UNCLASSIFIED	1025
		OROTIDINE 5′-PHOSPHATE DECARBOXYLASE (OMP	(PF00215) - Orotidine 5′-
		DECARBOXYLASE)	phosphate decarboxylases
1047	79244158 (4073, 4074)	Novel Protein sim. GBank gi|5596784|emb|CAB51431.1| - (AL096884)	Contains protein domain	UNCLASSIFIED	1035
		indoleglycerol phosphate synthase [Streptomyces coelicolor A3(2)]	(PF00218) - Indole-3-glycerol
			phosphate synthases
1048	20458135 (5183, 5184)		Contains protein domain	UNCLASSIFIED	1008
			(PF00220) - Neurohypophysial
			hormones, N-terminal Domain
1049	20285883 (6235, 6236)	Novel Protein sim. GBank gi|123761|sp|P24221|HUTH_STRGR -	Contains protein domain	UNCLASSIFIED	1031
		HISTIDINE AMMONIA-LYASE (HISTIDASE)	(PF00221) - Phenylalanine and
			histidine ammonia-lyases
1050	91212160 (163, 164)	Novel Protein sim. GBank gi|2429094 (U58632) - acetyl xylan esterase;	Contains protein domain	UNCLASSIFIED	1004, 1006, 1007, 1008,
		AxeA [Thermotoga neapolitana]	(PF00300) - Phosphoglycerate		1019, 1020, 1021, 1022,
			mutase family		1024, 1026, 1031
1051	47656836 (4965, 4966)		Contains protein domain	UNCLASSIFIED	1026
			(PF00303) - Thymidylate
			synthase
1052	86464771 (6233, 6234)	Novel Protein sim. GBank gi|118709|sp|P13454|DNAA_PSEPU -	Contains protein domain	UNCLASSIFIED	1026
		CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA	(PF00308) - Bacterial dnaA
			protein
1053	8760535 (8163, 8164)	Novel Protein sim. GBank gi|118709|sp|P13454|DNAA_PSEPU -	Contains protein domain	UNCLASSIFIED	1008
		CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA	(PF00308) - Bacterial dnaA
			protein
1054	80105238 (3949, 3950)	Novel Protein sim. GBank gi|3800785 (AF071024) - DNA replication	Contains protein domain	UNCLASSIFIED	1006, 1011, 1024
		initiator protein [Streptomyces chrysomallus]	(PF00308) - Bacterial dnaA
			protein
1055	80223034 (8949, 8950)	Novel Protein sim. GBank gi|114954|sp|P15703|BGL2_YEAST - GLUCAN	Contains protein domain	UNCLASSIFIED	1003, 1008, 1020, 1021,
		1,3-BETA-GLUCOSIDASE PRECURSOR (EXO-1,3-BETA-GLUCANASE)	(PF00332) - Glycosyl hydrolases		1022
		(GP29)	family 17
1056	47656597 (6485, 6486)	Novel Protein sim. GBank gi|4103623 (AF026470) - gluconate repressor	Contains protein domain	UNCLASSIFIED	1026
		[Pseudomonas aeruginosa]	(PF00356) - Bacterial regulatory
			proteins, lacl family
1057	66727485 (5461, 5462)	Novel Protein sim. GBank gi|1072995|pir||C53373 - hypothetical protein 2	Contains protein domain	UNCLASSIFIED	1046
		(rpoN 3′ region) - Pseudomonas aeruginosa	(PF00359) - phosphoenolpyruvate
			dependent sugar
			phosphotransferase system, EIIA 2
1058	38891752 (7405, 7406)	Novel Protein sim. GBank gi|1078080|pir||S53395 - hypothetical protein	Contains protein domain	UNCLASSIFIED	1006
		YLR316c - yeast (Saccharomyces cerevisiae)	(PF00383) - Cytidine and
			deoxycytidylate deaminase zinc-
			binding region
1059	8762096 (8401, 8402)	Novel Protein sim. GBank gi|1346565|sp|P49309|MOCR_RHIME -	Contains protein domain	UNCLASSIFIED	1020
		PROBABLE RHIZOPINE CATABOLISM REGULATORY PROTEIN MOCR	(PF00392) - Bacterial regulatory
			proteins, gntR family
1060	79261968 (447, 448)	Novel Protein sim. GBank gi|1709554|sp|P39946|PAC1_YEAST - PAC1	Contains protein domain	UNCLASSIFIED	1006
		PROTEIN	(PF00400) - WD domain, G-beta
			repeat
1061	79863295 (3421, 3422)	Novel Protein sim. GBank gi|3452553|dbj|BAA32473| - (AB001347) brain	Contains protein domain	UNCLASSIFIED	1004, 1015, 1031, 1036
		beta 3 spectrin [Rattus norvegicus]	(PF00435) - Spectrin repeat
1062	47652053 (1741, 1742)	Novel Protein sim. GBank gi|1781101|emb|CAB06235| - (Z83864)	Contains protein domain	UNCLASSIFIED	1026
		hypothetical protein Rv3855 [Mycobacterium tuberculosis]	(PF00440) - Bacterial regulatory
			proteins, tetR family
1063	78377787 (3107, 3108)	Novel Protein sim. GBank gi|2808724|emb|CAA16248| - (AL021428)	Contains protein domain	UNCLASSIFIED	1006
		hypothetical protein Rv0067c [Mycobacterium tuberculosis]	(PF00440) - Bacterial regulatory
			proteins, tetR family
1064	17906336 (2373, 2374)	Novel Protein sim. GBank gi|2815319|emb|CAA16443| - (AL021529)	Contains protein domain	UNCLASSIFIED	1002
		putative transcriptional regulator [Streptomyces coelicolor]	(PF00440) - Bacterial regulatory
			proteins, tetR family
1065	78475830 (651, 652)	Novel Protein sim. GBank gi|3261533|emb|CAA17469| - (AL021943)	Contains protein domain	UNCLASSIFIED	1002
		fadE8 [Mycobacterium tuberculosis]	(PF00441) - Acyl-CoA
			dehydrogenase
1066	80061653 (3377, 3378)	Novel Protein sim. GBank gi|1174887|sp|P42873|URE1_STAXY -	Contains protein domain	UNCLASSIFIED	1022
		UREASE ALPHA SUBUNIT (UREA AMIDOHYDROLASE)	(PF00449) - Urease
1067	32435619 (5559, 5560)	Novel Protein sim. GBank gi|882488 (U28377) - ORF_f118 [Escherichia	Contains protein domain	UNCLASSIFIED	1026
		coli]	(PF00460) - Flagella basal body
			rod proteins
1068	78918582 (8941, 8942)	Novel Protein sim. GBank gi|1168291|sp|P42449|ACEA_CORGL -	Contains protein domain	UNCLASSIFIED	1036
		ISOCITRATE LYASE (ISOCITRASE) (ISOCITRATASE) (ICL)	(PF00463) - Isocitrate lyase
1069	13022730 (1129, 1130)	Novel Protein sim. GBank gi|2811131 (AF013216) - isocitrate lyase	Contains protein domain	UNCLASSIFIED	1022
		[Myxococcus xanthus]	(PF00463) - Isocitrate lyase
1070	16705995 (981, 982)	Novel Protein sim. GBank gi|1172911|sp|P45833|RF1_MYCLE -	Contains protein domain	UNCLASSIFIED	1006
		PEPTIDE CHAIN RELEASE FACTOR 1 (RF-1)	(PF00472) - Prokaryotic-type
			class I peptide chain release
			factors
1071	78463975 (8009, 8010)	Novel Protein sim. GBank gi|2500143|sp|O05782|RF2_MYCTU -	Contains protein domain	UNCLASSIFIED	1015
		PEPTIDE CHAIN RELEASE FACTOR 2 (RF-2)	(PF00472) - Prokaryotic-type
			class I peptide chain release
			factors
1072	94989520 (863, 864)	Novel Protein sim. GBank gi|128710|sp|P03897|NU3M_HUMAN - NADH-	Contains protein domain	UNCLASSIFIED	1031
		UBIQUINONE OXIDOREDUCTASE CHAIN 3	(PF00507) - NADH-
			ubiquinone/plastoquinone
			oxidoreductase, chain 3
1073	27832079 (2441, 2442)	Novel Protein sim. GBank gi|584897|sp|P38042|CC27_YEAST - CELL	Contains protein domain	UNCLASSIFIED	1003, 1008, 1020
		DIVISION CONTROL PROTEIN 27	(PF00515) - TPR Domain
1074	29254635 (7039, 7040)	Novel Protein sim. GBank gi|3258282|dbj|BAA30965.1| - (AP000007)	Contains protein domain	UNCLASSIFIED	1006
		381 aa long hypothetical protein [Pyrococcus horikoshii]	(PF00534) - Glycosyl transferases
			group 1
1075	20297958 (3375, 3376)	Novel Protein sim. GBank gi|1168375|sp|P43467|AGA1_PEDPE - ALPHA	Contains protein domain	UNCLASSIFIED	1031
		GALACTOSIDASE 1 (MELIBIASE)	(PF00547) - Urease, gamma
			subunit
1076	80248091 (6713, 6714)	Novel Protein sim. GBank gi|2829506|sp|P71559|SUCC_MYCTU -	Contains protein domain	UNCLASSIFIED	1001, 1002, 1004, 1010,
		SUCCINYL-COA SYNTHETASE BETA CHAIN (SCS-BETA)	(PF00549) - CoA-ligases		1028, 1031
1077	80503640 (5001, 5002)	Novel Protein sim. GBank gi|1518185|emb|CAA65743| - (X97015)	Contains protein domain	UNCLASSIFIED	1010
		transposase [Arthrobacter nicotinovorans]	(PF00552) - Integrase
1078	80219757 (671, 672)	Novel Protein sim. GBank gi|2133114|pir||S69673 - SAC7 protein - yeast	Contains protein domain	UNCLASSIFIED	1001, 1006, 1015, 1020,
		(Saccharomyces cerevisiae)	(PF00556) - Antenna complex		1031, 1036
			alpha/beta subunit
1079	54531468 (3451, 3452)	Novel Protein sim. GBank gi|2981221 (AF053091) - eyelid [Drosophila	Contains protein domain	UNCLASSIFIED	1038
		melanogaster]	(PF00560) - Leucine Rich Repeat
1080	94666655 (8445, 8446)	Novel Protein sim. GBank gi|4068|emb|CAA44073| - (X62147) nud1	Contains protein domain	UNCLASSIFIED	1004
		[Saccharomyces cerevisiae]	(PF00580) - Leucine Rich Repeat
1081	29902323 (4019, 4020)	Novel Protein sim. GBank gi|313748|emb|CAA80797| - (Z23261)	Contains protein domain	UNCLASSIFIED	1006
		YBLO501 [Saccharomyces cerevisiae]	(PF00627) - UBA domain
1082	37800972 (3033, 3034)	Novel Protein sim. GBank gi|2654448 (U78300) - elongation factor G	Contains protein domain	UNCLASSIFIED	1010
		[Thiobacillus cuprinus]	(PF00679) - Elongation factor G C
			terminus
1083	8910323 (7533, 7534)	Novel Protein sim. GBank gi|100189|dbj|BAA10700| - (D64005) cation	Contains protein domain	UNCLASSIFIED	1036
		efflux system protein [Synechocystis sp.]	(PF00873) - AcrB/AcrD/AcrF
			family
1084	79599728 (6241, 6242)	Novel Protein sim. GBank gi|2506614|sp|P38054|YBDE_ECOLI -	Contains protein domain	UNCLASSIFIED	1002
		HYPOTHETICAL 114.7 KD PROTEIN IN NFRB-PHEP INTERGENIC	(PF00873) - AcrB/AcrD/AcrF
		REGION	family
1085	65448422 (6933, 6934)	Novel Protein sim. GBank gi|3025164|sp|P76398|YEGN_ECOLI -	Contains protein domain	UNCLASSIFIED	1007
		HYPOTHETICAL 112.1 KD PROTEIN IN ALKA-BAES INTERGENIC	(PF00873) - AcrB/AcrD/AcrF
		REGION	family
1086	29693301 (8999, 9000)	Novel Protein sim. GBank gi|2654484 (U89914) - hypothetical 16.1 kDa	Contains protein domain	UNCLASSIFIED	1022
		transcriptional regulator [Bacillus firmus]	(PF01047) - MarR family
1087	27843061 (5971, 5972)	Novel Protein sim. GBank gi|606223 (U18997) - we have one ORF,	Contains protein domain	UNCLASSIFIED	1020
		ECFMT has fmu and fmv [Escherichia coli]	(PF01189) - NOL1/NOP2/sun
			family
1088	30656288 (7647, 7648)	Novel Protein sim. GBank gi|1926279|emb|CAA71938| - (Y11043)	Contains protein domain	UNCLASSIFIED	1041
		hypothetical barstar-like protein [Bacillus subtills]	(PF01337) - Barstar (bamase
			inhibitor)
1089	17852010 (1477, 1478)	Novel Protein sim. GBank gi|3165570 (AF067946) - similar to Drosophila	Contains protein domain	UNCLASSIFIED	1002, 1031, 1036, 1055
		ring canal protein (kelch) (SW: Q04852) [Caenorhabditis elegans]	(PF01344) - Kelch motif
1090	80027802 (4143, 4144)	Novel Protein sim. GBank gi|2384563 (U70470) - beta-hydroxydecanoyl-	Contains protein domain	UNCLASSIFIED	1004, 1008, 1022, 1031
		ACP dehydrase [Pseudomonas aeruginosa]	(PF01377) - Thioester dehydrase
1091	10237183 (5701, 5702)		Contains protein domain	UNCLASSIFIED	1036
			(PF01381) - Helix-turn-helix
1092	77518931 (8643, 8644)	Novel Protein sim. GBank gi|2119159|pir||I50694 - alpha-1 collagen type	Contains protein domain	UNCLASSIFIED	1009, 1027, 1035
		III - chicken (fragment)	(PF01391) - Collagen triple helix
			repeat (20 copies)
1093	13526943 (3733, 3734)	Novel Protein sim. GBank gi|116515|sp|P22137|CLH_YEAST -	Contains protein domain	UNCLASSIFIED	1022
		CLATHRIN HEAVY CHAIN	(PF01394) - Clathrin propeller
			repeat
1094	78736414 (695, 696)	Novel Protein sim. GBank gi|2137494|pir||S66498 - M-sema F protein	Contains protein domain	UNCLASSIFIED	1006
		precusor - mouse	(PF01403) - Sema domain
1095	20562364 (4691, 4692)	Novel Protein sim. GBank gi|123938|sp|P24191|HYPC_ECOLI -	Contains protein domain	UNCLASSIFIED	1020
		HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPC	(PF01455) - HupF/HypC family
1096	56321668 (8963, 8964)	Novel Protein sim. GBank gi|2131341|pir||S67663 - hypothetical protein	Contains protein domain	UNCLASSIFIED	1007, 1020, 1024
		YDL120w - yeast (Saccharomyces cerevisiae)	(PF01491) - Frataxin-like domain
1097	17696277 (7913, 7914)	Novel Protein sim. GBank gi|1750115 (U66480) - YnaD [Bacillus subtilis]	Contains protein domain	UNCLASSIFIED	1015
			(PF01581) - FMRFamide related
			peptide family
1098	79322438 (6159, 6160)	Novel Protein sim. GBank gi|2578384|emb|CAA15469| - (AL008609)	Contains protein domain	UNCLASSIFIED	1008, 1026, 1050
		glycine cleavage system h protein [Mycobacterium leprae]	(PF01597) - Glycine cleavage H-
			protein
1099	20467324 (4961, 4962)		Contains protein domain	UNCLASSIFIED	1008
			(PF01816) - Leucine rich repeat
			variant
1100	11031760 (2651, 2652)	Novel Protein sim. GBank gi|40507|emb|CAA48850| - (X69104) ORF2	Contains protein domain	UNCLASSIFIED	1051
		[Corynebacterium glutamicum]	PF01836) - Transposase
1101	56007904 (8151, 8152)	Novel Protein sim. GBank gi|3025019|sp|O07734|YC20_MYCTU -	Contains protein domain	UNCLASSIFIED	1015
		HYPOTHETICAL 11.0 KD PROTEIN CY180.20C	(PF01910) - Protein of unknown
			function
1102	28800967 (751, 752)	Novel Protein sim. GBank gi|2916923|emb|CAA17670.1| - (AL022004)	Contains protein domain	UNCLASSIFIED	1020
		moaC2 [Mycobacterium tuberculosis]	(PF01967) - MoaC family
1103	36996478 (4807, 4808)	Novel Protein sim. GBank gi|1001461|dbj|BAA10087| - (D63999)		UNCLASSIFIED	1001
		hypothetical protein [Synechocystis sp.]
1104	78140654 (6529, 6530)	Novel Protein sim. GBank gi|100788|pir||S18733 - glutenin high molecular		UNCLASSIFIED	1014, 1019
		weight chain 1By9 precursor - wheat
1105	11417249 (455, 456)	Novel Protein sim. GBank gi|1044963|bbs|169646 - protamine		UNCLASSIFIED	1015
		[Monodonta turbinata, gonads, Peptide, 106 aa]
1106	20621948 (8297, 8298)	Novel Protein sim. GBank gi|1050749|emb|CAA61941| - (X89816) GSTR		UNCLASSIFIED	1003
		protein [Rhizobium leguminosarum]
1107	79835962 (8449, 8450)	Novel Protein sim. GBank gi|1050749|emb|CAA61941| - (X89816) GSTR		UNCLASSIFIED	1001, 1006
		protein [Rhizobium leguminosarum]
1108	19636755 (1255, 1256)	Novel Protein sim. GBank gi|1061334 (U34258) - cappuccino [Drosophila		UNCLASSIFIED	1022
		melanogaster]
1109	80245076 (3301, 3302)	Novel Protein sim. GBank gi|106322|pir||B34087 - hypothetical protein		UNCLASSIFIED	1002, 1003, 1006, 1015,
		(L1H 3′ region) - human			1022
1110	79412708 (9039, 9040)	Novel Protein sim. GBank gi|106322|pir||B34087 - hypothetical protein		UNCLASSIFIED	1022
		(L1H 3′ region) - human
1111	6770549 (5275, 5276)	Novel Protein sim. GBank gi|1072944|pir||A48008 - electron transfer		UNCLASSIFIED	1020
		flavoprotein beta chain - Paracoccus denitrificans
1112	37036768 (645, 646)	Novel Protein sim. GBank gi|1074262|pir||H64142 - hypothetical protein		UNCLASSIFIED	1010
		HI0107 - Haemophilus lnfluenzae (strain Rd KW20)
1113	79867038 (8391, 8392)	Novel Protein sim. GBank gi|1076211|pir||S50755 - hypothetical protein		UNCLASSIFIED	1021, 1022, 1035, 1041
		VSP-3 - Chlamydomonas reinhardtii
1114	98236309 (6833, 6834)	Novel Protein sim. GBank gi|1076627|pir||S54172 - inorganic		UNCLASSIFIED	1008, 1014
		pyrophosphatase (EC 3.6.1.1) - common tobacco
1115	78782677 (8245, 8246)	Novel Protein sim. GBank gi|1077247|pir||S52507 - probable membrane		UNCLASSIFIED	1020
		protein YDL012c - yeast (Saccharomyces cerevisiae)
1116	34885537 (3921, 3922)	Novel Protein sim. GBank gi|1077261|pir||S52527 - hypothetical protein		UNCLASSIFIED	1000
		YPL004c - yeast (Saccharomyces cerevisiae)
1117	29271303 (987, 988)	Novel Protein sim. GBank gi|1077262|pir||S52528 - hypothetical protein		UNCLASSIFIED	1002
		YPL003w - yeast (Saccharomyces cerevisiae)
1118	78518134 (2353, 2354)	Novel Protein sim. GBank gi|1077307|pir||S51892 - probable membrane		UNCLASSIFIED	1007
		protein YOL105c - yeast (Saccharomyces cerevisiae)
1119	80229807 (1721, 1722)	Novel Protein sim. GBank gi|1077333|pir||S51473 - probable membrane		UNCLASSIFIED	1004, 1006, 1022, 1036
		protein YLR386w - yeast (Saccharomyces cerevisiae)
1120	57535632 (8241, 8242)	Novel Protein sim. GBank gi|1077394|pir||S51408 - hypothetical protein		UNCLASSIFIED	1055
		YLR272c - yeast (Saccharomyces cerevisiae)
1121	39565537 (4731, 4732)	Novel Protein sim. GBank gi|1077522|pir||S51244 - hypothetical protein		UNCLASSIFIED	1008
		YDR095c - yeast (Saccharomyces cerevisiae)
1122	11398083 (6161, 6162)	Novel Protein sim. GBank gi|1077561|pir||S54050 - hypothetical protein		UNCLASSIFIED	1003, 1031
		YDR066c - yeast (Saccharomyces cerevisiae)
1123	10853113 (4429, 4430)	Novel Protein sim. GBank gi|1078406|pir||S47536 - SWH1 protein		UNCLASSIFIED	1001
		(version 2) - yeast (Saccharomyces cerevisiae)
1124	88094158 (7017, 7018)	Novel Protein sim. GBank gi|1079170|pir||S50125 - larval glue protein Lgp		UNCLASSIFIED	1003
		3 precursor - fruit fly (Drosophila virilis)
1125	37814616 (2801, 2802)	Novel Protein sim. GBank gi|1100076 (L49336) - PTS-dependent enzyme		UNCLASSIFIED	1055
		II [Clostridium longisporum]
1126	79614995 (8605, 8606)	Novel Protein sim. GBank gi|1118097 (U41557) - proline and glycine-rich		UNCLASSIFIED	1001, 1002
		[Caenorhabditis elegans]
1127	36824986 (7553, 7554)	Novel Protein sim. GBank gi|112205|pir||B39066 - proline-rich protein 15 -		UNCLASSIFIED	1051
		rat
1128	37802237 (2591, 2592)	Novel Protein sim. GBank gi|112261|pir||S16783 - hypothetical protein 2 -		UNCLASSIFIED	1055
		rat transposon L1
1129	33182574 (3505, 3506)	Novel Protein sim. GBank gi|112262|pir||S21976 - hypothetical protein 1 -		UNCLASSIFIED	1024
		rat transposon L1
1130	29915706 (3309, 3310)	Novel Protein sim. GBank gi|113666|sp|P23959|ALUA_HUMAN - !!!! ALU		UNCLASSIFIED	1022
		CLASS A WARNING ENTRY !!!!
1131	65704865 (3625, 3626)	Novel Protein sim. GBank gi|113666|sp|P23959|ALUA_HUMAN - !!!! ALU		UNCLASSIFIED	1002
		CLASS A WARNING ENTRY !!!!
1132	65327228 (4471, 4472)	Novel Protein sim. GBank gi|113668|sp|P23961 |ALUC_HUMAN - !!!! ALU		UNCLASSIFIED	1035
		CLASS C WARNING ENTRY !!!!
1133	11126833 (7295, 7296)	Novel Protein sim. GBank gi|113668|sp|P23961|ALUC_HUMAN - !!!! ALU		UNCLASSIFIED	1020
		CLASS C WARNING ENTRY !!!!
1134	85535625 (8715, 8716)	Novel Protein sim. GBank gi|113668|sp|P23961|ALUC_HUMAN - !!!! ALU		UNCLASSIFIED	1035
		CLASS C WARNING ENTRY !!!!
1135	13088036 (2409, 2410)	Novel Protein sim. GBank gi|1139566|dbj|BAA08630| - (D49826)		UNCLASSIFIED	1028
		unnamed protein product [Serratia marcescens]
1136	57522854 (759, 760)	Novel Protein sim. GBank gi|1146422 (U20254) - Ssu1p [Saccharomyces		UNCLASSIFIED	1003, 1020, 1023, 1031
		cerevisiae]
1137	57447671 (3191, 3192)	Novel Protein sim. GBank gi|114714|sp|P04694|ATTY_RAT - TYROSINE		UNCLASSIFIED	1055
		AMINOTRANSFERASE (L-TYROSINE: 2-OXOGLUTARATE
		AMINOTRANSFERASE) (TAT)
1138	20297108 (3713, 3714)	Novel Protein sim. GBank gi|114878|sp|P11435|BCPA_STRHY -		UNCLASSIFIED	1031
		CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE
		(CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE)
		(CPEP PHOSPHONOMUTASE)
1139	79633909 (1707, 1708)	Novel Protein sim. GBank gi|115405|sp|P20630|CC12_CAEEL -		UNCLASSIFIED	1035
		CUTICLE COLLAGEN 12 PRECURSOR
1140	27975264 (3003, 3004)	Novel Protein sim. GBank gi|115939|sp|P06961|CCA_ECOLI - TRNA		UNCLASSIFIED	1004
		NUCLEOTIDYLTRANSFERASE (TRNA ADENYLYLTRANSFERASE)
		(TRNA CCA-PYROPHOSPHORYLASE) (CCA-ADDING ENZYME)
1141	66489053 (1271, 1272)	Novel Protein sim. GBank gi|1160355 (U33058) - UNC-89 [Caenorhabditis		UNCLASSIFIED	1001, 1003, 1022, 1026
		elegans]
1142	37026059 (4289, 4290)	Novel Protein sim. GBank gi|116371|sp|P17552|CHRB_ALCEU - CHRB		UNCLASSIFIED	1035
		PROTEIN
1143	57292564 (1379, 1380)	Novel Protein sim. GBank gi|1164988|emb|CAA64063| - (X94335)		UNCLASSIFIED	1006, 1008, 1020
		YOR3513c [Saccharomyces cerevisiae]
1144	11808714 (955, 956)	Novel Protein sim. GBank gi|116837|sp|P21636|COBF_PSEDE - COBF		UNCLASSIFIED	1020
		PROTEIN
1145	86473327 (3299, 3300)	Novel Protein sim. GBank gi|1169153|sp|P46356|CYAY_YERPE - CYAY		UNCLASSIFIED	1026
		PROTEIN
1146	79607194 (1509, 1510)	Novel Protein sim. GBank gi|1169255|sp|P42503|DCUP_RHOCA -		UNCLASSIFIED	1004, 1036
		UROPORPHYRINOGEN DECARBOXYLASE (UPD)
1147	65682712 (1863, 1864)	Novel Protein sim. GBank gi|1171060|sp|P43505|MTRC_NEIGO -		UNCLASSIFIED	1008, 1021
		MEMBRANE FUSION PROTEIN MTRC PRECURSOR
1148	86475460 (4097, 4098)	Novel Protein sim. GBank gi|1171071|sp|P45066|MURC_HAEIN - UDP-N-		UNCLASSIFIED	1045
		ACETYLMURAMATE-ALANINE LIGASE (UDP-N-ACETYLMURANOYL-L
		ALANINE SYNTHETASE)
1149	20610309 (1999, 2000)	Novel Protein sim. GBank gi|1172069|sp|P45494|PEPV_LACDL - XAA-		UNCLASSIFIED	1004
		HIS DIPEPTIDASE (X-HIS DIPEPTIDASE) (AMINOACYL-HISTIDINE
		DIPEPTIDASE) (CARNOSINASE)
1150	37018030 (3265, 3266)	Novel Protein sim. GBank gi|1172069|sp|P45494|PEPV_LACDL - XAA-		UNCLASSIFIED	1023
		HIS DIPEPTIDASE (X-HIS DIPEPTIDASE) (AMINOACYL-HISTIDINE
		DIPEPTIDASE) (CARNOSINASE)
1151	20608541 (3129, 3130)	Novel Protein sim. GBank gi|1172509|sp|P42257|PILJ_PSEAE - PILJ		UNCLASSIFIED	1003
		PROTEIN
1152	79173584 (3163, 3164)	Novel Protein sim. GBank gi|1172783|sp|P41008|PYRB_BACCL -		UNCLASSIFIED	1028
		ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE
		TRANSCARBAMYLASE) (ATCASE)
1153	25256802 (8809, 8810)	Novel Protein sim. GBank gi|1173364|sp|P45380|SAT1_RAT - SULFATE		UNCLASSIFIED	1006
		ANION TRANSPORTER 1 (CANALICULAR SULFATE TRANSPORTER)
		(SULFATE/CARBONATE ANTIPORTER)
1154	80411891 (8975, 8976)	Novel Protein sim. GBank gi|1174661|sp|P44594|TGT_HAEIN -		UNCLASSIFIED	1026, 1041
		QUEUINE TRNA-RIBOSYLTRANSFERASE (TRNA-GUANINE
		TRANSGLYCOSYLASE) (GUANINE INSERTION ENZYME)
1155	11102917 (8767, 8768)	Novel Protein sim. GBank gi|1175364|sp|Q09686|YA14_SCHPO -		UNCLASSIFIED	1004, 1022
		HYPOTHETICAL 28.0 KD PROTEIN C13C5.04 IN CHROMOSOME I
1156	11088365 (5787, 5788)	Novel Protein sim. GBank gi|1175473|sp|P44555|YAAJ_HAEIN -		UNCLASSIFIED	1003
		HYPOTHETICAL PROTEIN HI0183
1157	11122739 (8465, 8466)	Novel Protein sim. GBank gi|1175939|sp|P43567|YFD0_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 41.9 KD PROTEIN IN HAC1-CAK1 INTERGENIC
		REGION
1158	79873114 (7261, 7262)	Novel Protein sim. GBank gi|1175941|sp|P43564|YFD4_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 119.5 KD PROTEIN IN MOB2-RIM15 INTERGENIC
		REGION
1159	11413362 (8687, 8688)	Novel Protein sim. GBank gi|1176206|sp|P46481 |YHCP_ECOLI -		UNCLASSIFIED	1051
		HYPOTHETICAL 73.6 KD PROTEIN IN ARGR-CAFA INTERGENIC
		REGION (F655)
1160	80050336 (8197, 8198)	Novel Protein sim. GBank gi|1176207|sp|P46482|YHCQ_ECOLI -		UNCLASSIFIED	1004
		HYPOTHETICAL 34.8 KD PROTEIN IN ARGR-CAFA INTERGENIC
		REGION
1161	78785842 (4443, 4444)	Novel Protein sim. GBank gi|1176918|sp|P24089|YSY2_YEAST -		UNCLASSIFIED	1007, 1041
		HYPOTHETICAL 137.7 KD PROTEIN IN SUBTELOMERIC Y' REPEAT
		REGION OF CHR XV (ORF 2)
1162	32571568 (2903, 2904)	Novel Protein sim. GBank gi|1176968|sp|P42107|YXAH_BACSU -		UNCLASSIFIED	1031
		HYPOTHETICAL 46.2 KD PROTEIN IN GNTR-HTPG INTERGENIC
		REGION
1163	78435203 (3411, 3412)	Novel Protein sim. GBank gi|119111|sp|P12978|EBN2_EBV - EBNA-2		UNCLASSIFIED	1020
		NUCLEAR PROTEIN
1164	78996721 (4617, 4618)	Novel Protein sim. GBank gi|120450|sp|P27251|DEF_ECOLI -		UNCLASSIFIED	1007, 1041
		POLYPEPTIDE DEFORMYLASE (PDF) (FORMYLMETHIONINE
		DEFORMYLASE)
1165	10159084 (8761, 8762)	Novel Protein sim. GBank gi|120475|sp|P05523|FPG_ECOLI -		UNCLASSIFIED	1003
		FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FAPY-DNA
		GLYCOSYLASE)
1166	17869389 (2211, 2212)	Novel Protein sim. GBank gi|120943|sp|P13816|GARP_PLAFF -		UNCLASSIFIED	1006, 1022
		GLUTAMIC ACID-RICH PROTEIN PRECURSOR
1167	19877214 (7289, 7290)	Novel Protein sim. GBank gi|121191|sp|P17113|GIDB_ECOLI -		UNCLASSIFIED	1031
		GLUCOSE INHIBITED DIVISION PROTEIN B
1168	21434344 (4413, 4414)	Novel Protein sim. GBank gi|1213021|emb|CAA59198| - (X84710)		UNCLASSIFIED	1031
		ORF492, surface antigen gene [Methanosarcina mazei]
1169	25154002 (4817, 4818)	Novel Protein sim. GBank gi|121661|sp|P06980|GSH1_ECOLI -		UNCLASSIFIED	1002, 1021
		GLUTAMATE-CYSTEINE LIGASE (GAMMA-GLUTAMYLCYSTEINE
		SYNTHETASE) (GAMMA-ECS) (GCS)
1170	66051387 (1571, 1572)	Novel Protein sim. GBank gi|1228093|emb|CAA87011| - (Z46913)		UNCLASSIFIED	1008
		polyketide synthase [Streptomyces ambofaciens]
1171	38895546 (5193, 5194)	Novel Protein sim. GBank gi|122829|sp|P13581|HEM1_SALTY -		UNCLASSIFIED	1006
		GLUTAMYL-TRNA REDUCTASE (GLUTR)
1172	65503633 (1909, 1910)	Novel Protein sim. GBank gi|123166|sp|P28735|HIS8_MYCSM -		UNCLASSIFIED	1046
		HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (IMIDAZOLE
		ACETOL-PHOSPHATE TRANSAMINASE)
1173	78784365 (2173, 2174)	Novel Protein sim. GBank gi|124890|sp|P19158|IRA2_YEAST -		UNCLASSIFIED	1020
		INHIBITORY REGULATOR PROTEIN IRA2
1174	20385137 (8785, 8786)	Novel Protein sim. GBank gi|125329|sp|P04951|KDSB_ECOLI - 3-		UNCLASSIFIED	1003
		DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERASE (CMP-
		KDO SYNTHETASE) (CMP-2-KETO-3-DEOXYOCTULOSONIC ACID
		SYNTHETASE) (CKS)
1175	78901612 (1513, 1514)	Novel Protein sim. GBank gi|125682|sp|P26372|KRUC_SHEEP -		UNCLASSIFIED	1002
		KERATIN, ULTRA HIGH-SULFUR MATRIX PROTEIN (UHS KERATIN)
1176	27829679 (8249, 8250)	Novel Protein sim. GBank gi|125733|sp|P10716|KUCR_RAT - KUPFFER		UNCLASSIFIED	1003, 1031
		CELL RECEPTOR
1177	36514909 (6095, 6096)	Novel Protein sim. GBank gi|125970|sp|P14206|RSP4_MOUSE - 40S		UNCLASSIFIED	1026
		RIBOSOMAL PROTEIN SA (P40) (34/67 KD LAMININ RECEPTOR)
1178	90936861 (8621, 8622)	Novel Protein sim. GBank gi|126722|sp|P27046|MAN2_MOUSE - ALPHA-		UNCLASSIFIED	1018
		MANNOSIDASE II (MANNOSYL-OLIGOSACCHARIDE 1,3-1,6-ALPHA-
		MANNOSIDASE) (MAN II) (GOLGI ALPHA-MANNOSIDASE II)
1179	55284151 (4053, 4054)	Novel Protein sim. GBank gi|127320|sp|P24202|MRR_ECOLI - MRR		UNCLASSIFIED	1050
		RESTRICTION SYSTEM PROTEIN
1180	85526278 (6895, 6896)	Novel Protein sim. GBank gi|127549|sp|P11652|MUTA_PROFR -		UNCLASSIFIED	1004, 1006, 1008, 1010,
		METHYLMALONYL-COA MUTASE BETA-SUBUNIT (MCB-BETA)			1020, 1021, 1026, 1031,
					1036, 1041, 1046
1181	78524503 (889, 890)	Novel Protein sim. GBank gi|128405|sp|P16313|NO21_SOYBN -		UNCLASSIFIED	1002, 1051
		NODULIN 21 (N-21)
1182	30577018 (6069, 6070)	Novel Protein sim. GBank gi|130084|sp|P06200|PHLC_PSEAE -		UNCLASSIFIED	1007
		HEMOLYTIC PHOSPHOLIPASE C PRECURSOR (HEAT LABILE-
		HEMOLYSIN) (PHOSPHATIDYLCHOLINE
		CHOLINEPHOSPHOHYDROLASE)
1183	20465412 (6557, 6558)	Novel Protein sim. GBank gi|130367|sp|P22253|PNCB_SALTY -		UNCLASSIFIED	1008
		NICOTINATE PHOSPHORIBOSYLTRANSFERASE (NAPRTASE)
1184	27982145 (715, 716)	Novel Protein sim. GBank gi|1304154|dbj|BAA11461| - (D78644) DNA		UNCLASSIFIED	1004
		polymerase [Mus musculus]
1185	10158862 (4243, 4244)	Novel Protein sim. GBank gi|130998|sp|P02812|PRP2_HUMAN -		UNCLASSIFIED	1002, 1055
		SALIVARY PROLINE-RICH PROTEIN PRECURSOR (CLONE CP7)
		[CONTAINS: BASIC PEPTIDE P-F]
1186	23281336 (331, 332)	Novel Protein sim. GBank gi|131225|sp|P23993|PSAL_HORVU -		UNCLASSIFIED	1002
		PHOTOSYSTEM I REACTION CENTRE SUBUNIT XI PRECURSOR
		(SUBUNIT V) (PSI-L)
1187	23292290 (869, 870)	Novel Protein sim. GBank gi|1313926|emb|CAA66267| - (X97677) non		UNCLASSIFIED	1015
		intermediate filament IFA binding protein [Brassica oleracea]
1188	80497275 (5069, 5070)	Novel Protein sim. GBank gi|1314835 (U56084) - exogenous ferric		UNCLASSIFIED	1010
		siderophore receptor [Bordetella bronchiseptica]
1189	9354676 (2687, 2688)	Novel Protein sim. GBank gi|132360|sp|P05684|REPC_AGRRA -		UNCLASSIFIED	1006
		POSSIBLE REPLICATION PROTEIN C
1190	79233832 (775, 776)	Novel Protein sim. GBank gi|132523|sp|P19263|RGR1_YEAST -		UNCLASSIFIED	1001, 1006, 1024, 1041
		GLUCOSE REPRESSION REGULATORY PROTEIN RGR1
1191	79261586 (1819, 1820)	Novel Protein sim. GBank gi|134515|sp|P17883|SKI3_YEAST -		UNCLASSIFIED	1021, 1046
		SUPERKILLER 3 PROTEIN
1192	82476553 (7859, 7860)	Novel Protein sim. GBank gi|1346647|sp|P49687|N145_YEAST -		UNCLASSIFIED	1001, 1006, 1008, 1010,
		NUCLEOPORIN NUP145 (NUCLEAR PORE PROTEIN NUP145)			1015, 1020, 1022, 1031,
					1051
1193	95293062 (615, 616)	Novel Protein sim. GBank gi|1346722|sp|P49022|PIP_LACLA - PHAGE		UNCLASSIFIED	1020
		INFECTION PROTEIN
1194	10340949 (1031, 1032)	Novel Protein sim. GBank gi|1346910|sp|P28650|PUA1_MOUSE -		UNCLASSIFIED	1035
		ADENYLOSUCCINATE SYNTHETASE, MUSCLE ISOZYME (IMP-
		ASPARTATE LIGASE)
1195	27981812 (1067, 1068)	Novel Protein sim. GBank gi|134780|sp|P14328|SP96_DICDI - SPORE		UNCLASSIFIED	1004
		COAT PROTEIN SP96
1196	79854352 (6415, 6416)	Novel Protein sim. GBank gi|134837|sp|P17580|SPOT_ECOLI -		UNCLASSIFIED	1015, 1021, 1036
		GUANOSINE-3′,5′-BIS(DIPHOSPHATE) 3′-
		PYROPHOSPHOHYDROLASE ((PPGPP)ASE) (PENTA-PHOSPHATE
		GUANOSINE-3′-PYROPHOSPHOHYDROLASE)
1197	30422207 (3329, 3330)	Novel Protein sim. GBank gi|135083|sp|P24506|SY62_DISOM -		UNCLASSIFIED	1041
		SYNAPTOTAGMIN B (SYNAPTIC VESICLE PROTEIN O-P65-B)
1198	80083733 (2665, 2666)	Novel Protein sim. GBank gi|1351184|sp|P48527|SYYM_YEAST -		UNCLASSIFIED	1020, 1031
		TYROSYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR
		(TYROSINE-TRNA LIGASE) (TYRRS)
1199	20736833 (8379, 8380)	Novel Protein sim. GBank gi|135139|sp|P15180|SYKC_YEAST - LYSYL-		UNCLASSIFIED	1020
		TRNA SYNTHETASE, CYTOPLASMIC (LYSINE - TRNA LIGASE)
		(LYSRS)
1200	20628105 (2559, 2560)	Novel Protein sim. GBank gi|1351821|sp|P48236|YG3L_YEAST -		UNCLASSIFIED	1008
		HYPOTHETICAL 51.6 KD PROTEIN IN RPL30B-RSR1 INTERGENIC
		REGION
1201	80219752 (9051, 9052)	Novel Protein sim. GBank gi|1352873|sp|P47101|YJ00_YEAST -		UNCLASSIFIED	1003, 1004, 1022, 1027,
		HYPOTHETICAL 84.3 KD PROTEIN IN BNA1-CPR7 INTERGENIC			1041
		REGION
1202	80245061 (1369, 1370)	Novel Protein sim. GBank gi|1352874|sp|P47102|YJ01_YEAST -		UNCLASSIFIED	1004, 1006, 1008, 1020
		HYPOTHETICAL 159.4 KD PROTEIN IN MER2-CPR7 INTERGENIC
		REGION
1203	24141321 (6563, 6564)	Novel Protein sim. GBank gi|1352890|sp|P47123|YJ44_YEAST -		UNCLASSIFIED	1007
		HYPOTHETICAL 24.3 KD PROTEIN IN PEM2-HOC1 INTERGENIC
		REGION
1204	78790208 (1267, 1268)	Novel Protein sim. GBank gi|1352977|sp|P47050|YJE7_YEAST -		UNCLASSIFIED	1020, 1024
		HYPOTHETICAL 99.3 KD PROTEIN IN MTR4-GYP6 INTERGENIC
		REGION
1205	80217268 (5755, 5756)	Novel Protein sim. GBank gi|1352984|sp|P47044|YJF5_YEAST -		UNCLASSIFIED	1003, 1008, 1020, 1022,
		HYPOTHETICAL 26.9 KD PROTEIN IN BTN1-PEP8 INTERGENIC			1024, 1035
		REGION
1206	78757501 (4597, 4598)	Novel Protein sim. GBank gi|1352989|sp|P47037|SMC3_YEAST -		UNCLASSIFIED	1041
		CHROMOSOME SEGREGATION PROTEIN SMC3 (DA-BOX PROTEIN
		SMC3)
1207	8499085 (8377, 8378)	Novel Protein sim. GBank gi|1352991|sp|P47035|YJH6_YEAST -		UNCLASSIFIED	1020, 1031
		HYPOTHETICAL 128.5 KD PROTEIN IN SCP160-SMC3 INTERGENIC
		REGION
1208	12829405 (2879, 2880)	Novel Protein sim. GBank gi|1353040|sp|P46985|YJS3_YEAST -		UNCLASSIFIED	1028
		HYPOTHETICAL 47.8 KD PROTEIN IN SWE1-ATP12 INTERGENIC
		REGION
1209	79827901 (1813, 1814)	Novel Protein sim. GBank gi|135514|sp|P06333|TCB1_RABIT - T-CELL		UNCLASSIFIED	1002, 1006
		RECEPTOR BETA CHAIN PRECURSOR (ANA 11)
1210	79114433 (3251, 3252)	Novel Protein sim. GBank gi|135514|sp|P06333|TCB1_RABIT - T-CELL		UNCLASSIFIED	1041
		RECEPTOR BETA CHAIN PRECURSOR (ANA 11)
1211	78781913 (3323, 3324)	Novel Protein sim. GBank gi|135969|sp|P21269|CCA1_YEAST - TRNA		UNCLASSIFIED	1007
		NUCLEOTIDYLTRANSFERASE PRECURSOR (TRNA
		ADENYLYLTRANSFERASE) (TRNA CCA-PYROPHOSPHORYLASE)
		(CCA-ADDING ENZYME)
1212	85817924 (8597, 8598)	Novel Protein sim. GBank gi|1360914|pir||D56279 - coxL 3′-region		UNCLASSIFIED	1017
		hypothetical protein - Pseudomonas carboxydovorans
1213	20292767 (823, 824)	Novel Protein sim. GBank gi|1361153|pir||S56602 - hypothetical protein		UNCLASSIFIED	1031
		o211 - Escherichia coli
1214	27981679 (2195, 2196)	Novel Protein sim. GBank gi|1361210|pir||S56383 - lysyl-tRNA synthetase		UNCLASSIFIED	1004
		homolog protein genX - Escherichia coli
1215	79841698 (89, 90)	Novel Protein sim. GBank gi|1361224|pir||S56597 - peptide N-		UNCLASSIFIED	1041
		acetyltransferase (EC 2.3.1.—) riml - Escherichia coli
1216	27366674 (3367, 3368)	Novel Protein sim. GBank gi|136242|sp|P15565|TRM1_YEAST - N2, N2-		UNCLASSIFIED	1020
		DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE PRECURSOR
1217	47652223 (7991, 7992)	Novel Protein sim. GBank gi|1364110|pir||S57490 - molybdopterin		UNCLASSIFIED	1026
		cofactor synthesis protein - Arthrobacter nicotinovorans (fragment)
1218	29686789 (2183, 2184)	Novel Protein sim. GBank gi|137616|sp|P03708|TERL_LAMBD -		UNCLASSIFIED	1035
		TERMINASE LARGE SUBUNIT (DNA PACKAGING PROTEIN A) (GPA)
1219	10355461 (1093, 1094)	Novel Protein sim. GBank gi|139859|sp|P07859|XYLS_PSEPU -		UNCLASSIFIED	1036
		XYLDLEGF OPERON TRANSCRIPTIONAL ACTIVATOR
1220	17682824 (7251, 7252)	Novel Protein sim. GBank gi|140372|sp|P25569|YCD9_YEAST -		UNCLASSIFIED	1036
		HYPOTHETICAL 86.0 KD PROTEIN IN GLK1-SRO9 INTERGENIC
		REGION
1221	27961532 (4571, 4572)	Novel Protein sim. GBank gi|140449|sp|P25349|YCP4_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 26.4 KD PROTEIN IN CDC10-CIT2 INTERGENIC
		REGION
1222	78382668 (1551, 1552)	Novel Protein sim. GBank gi|140499|sp|P25627|YCT7_YEAST -		UNCLASSIFIED	1002
		PUTATIVE 30.7 KD METHYLTRANSFERASE IN TSM1-ARE1
		INTERGENIC REGION
1223	10139501 (7153, 7154)	Novel Protein sim. GBank gi|141308|sp|P24562|YPT5_PSEAE -		UNCLASSIFIED	1015
		HYPOTHETICAL 24.5 KD PROTEIN IN PILT 5′REGION (ORF5)
1224	79832459 (35, 36)	Novel Protein sim. GBank gi|141515|sp|P25639|YCV1_YEAST -		UNCLASSIFIED	1006, 1015, 1021, 1041
		HYPOTHETICAL 65.0 KD PROTEIN IN PWP2-SUP61 INTERGENIC
		REGION
1225	79194684 (5007, 5008)	Novel Protein sim. GBank gi|142856 (M96343) - MreC protein [Bacillus		UNCLASSIFIED	1022
		subtilis]
1226	21392310 (2121, 2122)	Novel Protein sim. GBank gi|1652190|dbj|BAA17114| - (D90903) Fat		UNCLASSIFIED	1020
		protein [Synechocystis sp.]
1227	78971760 (7603, 7604)	Novel Protein sim. GBank gi|1652359|dbj|BAA17282| - (D90904)		UNCLASSIFIED	1006
		hypothetical protein [Synechocystis sp.]
1228	77517367 (3317, 3318)	Novel Protein sim. GBank gi|1652721|dbj|BAA17641| - (D90907),		UNCLASSIFIED	1009
		hypothetical protein [Synechocystis sp.]
1229	37800949 (3341, 3342)	Novel Protein sim. GBank gi|1653898|dbj|BAA18808| - (D90917)		UNCLASSIFIED	1010
		hypothetical protein [Synechocystis sp.]
1230	8058034 (3197, 3198)	Novel Protein sim. GBank gi|1655648|emb|CAB03747| - (Z81368)		UNCLASSIFIED	1008
		hypothetical protein Rv2411c [Mycobacterium tuberculosis]
1231	27977068 (501, 502)	Novel Protein sim. GBank gi|1655665|emb|CAB03731| - (Z81368)		UNCLASSIFIED	1020
		hypothetical protein Rv2395 [Mycobacterium tuberculosis]
1232	78528471 (2835, 2836)	Novel Protein sim. GBank gi|1655665|emb|CAB03731| - (Z81368)		UNCLASSIFIED	1027
		hypothetical protein Rv2395 [Mycobacterium tuberculosis]
1233	17287840 (8459, 8460)	Novel Protein sim. GBank gi|1655699|emb|CAA69032| - (Y07752)		UNCLASSIFIED	1006
		pherophorin-S [Volvox carteri]
1234	20286667 (5773, 5774)	Novel Protein sim. GBank gi|1655830 (U59446) - myrosinase-binding		UNCLASSIFIED	1020
		protein related protein [Brassica napus]
1235	8515876 (3545, 3546)	Novel Protein sim. GBank gi|1657554|gb|AAB18082.1| - (U73857)		UNCLASSIFIED	1050
		hypothetical protein [Escherichia coli]
1236	11398315 (7929, 7930)	Novel Protein sim. GBank gi|1665720|dbj|BAA04134| - (D17312) diarrheal		UNCLASSIFIED	1004
		toxin [Bacillus cereus]
1237	70451388 (1087, 1088)	Novel Protein sim. GBank gi|1694865|emb|CAB05411| - (Z83018)		UNCLASSIFIED	1046
		hypothetical protein Rv2966c [Mycobacterium tuberculosis]
1238	39527331 (2135, 2136)	Novel Protein sim. GBank gi|1703287|sp|Q11010|AMPN_STRLI -		UNCLASSIFIED	1004
		AMINOPEPTIDASE N (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE
		AMINOPEPTIDASE)
1239	57293758 (6717, 6718)	Novel Protein sim. GBank gi|1705514|sp|P53226|BUD9_YEAST - BUD		UNCLASSIFIED	1020, 1024, 1031
		SITE SELECTION PROTEIN BUD9
1240	35125857 (6169, 6170)	Novel Protein sim. GBank gi|1706439|sp|P53388|DIP5_YEAST -		UNCLASSIFIED	1024
		DICARBOXYLIC AMINO ACID PERMEASE
1241	20284542 (7213, 7214)	Novel Protein sim. GBank gi|1707878|sp|P54260|GCST_SOLTU -		UNCLASSIFIED	1020
		AMINOMETHYL TRANSFERASE PRECURSOR (GLYCINE CLEAVAGE
		SYSTEM T PROTEIN)
1242	65466577 (6647, 6648)	Novel Protein sim. GBank gi|1708467|sp|P54689|ILVE_HAEIN -		UNCLASSIFIED	1008
		BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE
		(TRANSAMINASE B) (BCAT)
1243	78184318 (53, 54)	Novel Protein sim. GBank gi|1709220|sp|P53792|SL52_RAT -		UNCLASSIFIED	1020, 1024
		SODIUM/GLUCOSE COTRANSPORTER 2 (NA(+)/GLUCOSE
		COTRANSPORTER 2) (LOW AFFINITY SODIUM-GLUCOSE
		COTRANSPORTER)
1244	9875298 (5491, 5492)	Novel Protein sim. GBank gi|1709675|sp|P52832|PMGI_PSESM - 2,3-		UNCLASSIFIED	1041
		BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE
		MUTASE (PHOSPHOGLYCEROMUTASE) (BPG-INDEPENDENT PGAM)
1245	29363896 (1331, 1332)	Novel Protein sim. GBank gi|1709888|sp|P32606|PT27_YEAST -		UNCLASSIFIED	1041
		PUTATIVE MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT
		PET127
1246	6345797 (5859, 5860)	Novel Protein sim. GBank gi|1710124 (U62279) - leucine-rich repeat-		UNCLASSIFIED	1055
		containing extracellular glycoprotein; contains six N-glycosylation sites
		[NX(S/T)][Sorghum bicolor]
1247	52563343 (4645, 4646)	Novel Protein sim. GBank gi|1710635|sp|P51862|ROM2_YEAST - RHO1		UNCLASSIFIED	1036, 1041
		GDP-GTP EXCHANGE PROTEIN 2
1248	80425372 (3687, 3688)	Novel Protein sim. GBank gi|171407 (M83540) - DNA52 [Saccharomyces		UNCLASSIFIED	1002, 1003, 1004, 1008,
		cerevisiae]			1020, 1022, 1023, 1025,
					1028, 1031, 1041
1249	80500805 (4953, 4954)	Novel Protein sim. GBank gi|171732 (M14048) - histidine-tRNA		UNCLASSIFIED	1003, 1004, 1006, 1008,
		synthetase mitochondrial [Saccharomyces cerevisiae]			1010, 1015, 1020, 1021,
					1022, 1028, 1031
1250	80233117 (6873, 6874)	Novel Protein sim. GBank gi|1722927|sp|Q10403|Y00R_MYCTU -		UNCLASSIFIED	1050
		HYPOTHETICAL 31.7 KD PROTEIN CY190.27
1251	20395631 (7625, 7626)	Novel Protein sim. GBank gi|1723055|sp|Q11019|Y07D_MYCTU -		UNCLASSIFIED	1003
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN
		CY02B10.13
1252	38406202 (5707, 5708)	Novel Protein sim. GBank gi|1723184|sp|P39732|YAD1_YEAST -		UNCLASSIFIED	1006, 1024
		HYPOTHETICAL 86.6 KD PROTEIN IN PYK1-SNC1 INTERGENIC
		REGION
1253	78716228 (4699, 4700)	Novel Protein sim. GBank gi|1723646|sp|P53208|YG19_YEAST -		UNCLASSIFIED	1015
		HYPOTHETICAL 37.9 KD PROTEIN IN MSB2-UGA1 INTERGENIC
		REGION
1254	57292728 (7061, 7062)	Novel Protein sim. GBank gi|1723655|sp|P53217|YG1I_YEAST -		UNCLASSIFIED	1003, 1004, 1020, 1022,
		HYPOTHETICAL 33.3 KD PROTEIN IN VMA7-RPS31A INTERGENIC			1024, 1031
		REGION
1255	80502396 (3345, 3346)	Novel Protein sim. GBank gi|1723660|sp|P53223|YG1P_YEAST -		UNCLASSIFIED	1002, 1004, 1007, 1010,
		HYPOTHETICAL 27.6 KD PROTEIN IN RPL26B-ACB1 INTERGENIC			1020, 1021, 1024, 1028
		REGION
1256	27929655 (2817, 2818)	Novel Protein sim. GBank gi|1723691|sp|P53259|YG2Q_YEAST -		UNCLASSIFIED	1003, 1004, 1020, 1022,
		HYPOTHETICAL 38.8 KD PROTEIN IN MIC1-SRB5 INTERGENIC			1051
		REGION
1257	10311849 (1137, 1138)	Novel Protein sim. GBank gi|1723730|sp|P53297|YG42_YEAST -		UNCLASSIFIED	1041
		HYPOTHETICAL 78.8 KD PROTEIN IN ATF2-RNR4 INTERGENIC
		REGION
1258	38908728 (1881, 1882)	Novel Protein sim. GBank gi|1723762|sp|P53314|YG59_YEAST -		UNCLASSIFIED	1001, 1002, 1024
		HYPOTHETICAL 26.7 KD PROTEIN IN TDS4-MGA1 INTERGENIC
		REGION
1259	57292866 (5525, 5526)	Novel Protein sim. GBank gi|1723927|sp|P53117|YGO6_YEAST -		UNCLASSIFIED	1004, 1020, 1022
		HYPOTHETICAL 34.7 KD PROTEIN IN RPL9A-TIP20 INTERGENIC
		REGION
1260	29225446 (4855, 4856)	Novel Protein sim. GBank gi|1723969|sp|P53075|YGX8_YEAST -		UNCLASSIFIED	1006
		HYPOTHETICAL 66.9 KD PROTEIN IN SAP4-OST5 INTERGENIC
		REGION
1261	27838107 (6437, 6438)	Novel Protein sim. GBank gi|1723978|sp|P53066|YGZ2_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 20.1 KD PROTEIN IN RTF1-CSE1 INTERGENIC
		REGION
1280	80505214 (8991, 8992)	Novel Protein sim. GBank gi|1805408|dbj|BAA08970| - (D50453)		UNCLASSIFIED	1010
		homologues to nitrile hydratase region 3′-hypothetical protein P47K of P.
		chlororaphis [Bacillus subtilis]
1281	82062248 (2803, 2804)	Novel Protein sim. GBank gi|1841552 (U89336) - unknown [Homo		UNCLASSIFIED	1004, 1008, 1014, 1020,
		sapiens]			1022, 1026, 1031, 1036,
					1041, 1050
1282	79582448 (7769, 7770)	Novel Protein sim. GBank gi|1870009|emb|CAB06860| - (Z92539)		UNCLASSIFIED	1022
		hypothetical protein Rv1019 [Mycobacterium tuberculosis]
1283	85800377 (7057, 7058)	Novel Protein sim. GBank gi|1872200 (U22376) - alternatively spliced		UNCLASSIFIED	1023
		product using exon 13A [Homo sapiens]
1284	70287165 (8165, 8166)	Novel Protein sim. GBank gi|1877309|emb|CAB07152| - (Z92774) arsB2		UNCLASSIFIED	1007
		[Mycobacterium tuberculosis]
1285	80503107 (2991, 2992)	Novel Protein sim. GBank gi|1877310|emb|CAB07153| - (Z92774)		UNCLASSIFIED	1004, 1006, 1010, 1031,
		hypothetical protein Rv3579c [Mycobacterium tuberculosis]			1041, 1051
1286	79574310 (5127, 5128)	Novel Protein sim. GBank gi|1881338|dbj|BAA19365| - (AB001488)		UNCLASSIFIED	1028
		PROBABLE INTEGRAL MEMBRANE PROTEIN, SIMILAR TO
		CHLORAMPHENICOL RESISTANCE PROTEIN OF STREPTOMYCES
		VENEZUELAE. [Bacillus subtilis]
1287	10329996 (7763, 7764)	Novel Protein sim. GBank gi|1881338|dbj|BAA19365| - (AB001488)		UNCLASSIFIED	1002
		PROBABLE INTEGRAL MEMBRANE PROTEIN, SIMILAR TO
		CHLORAMPHENICOL RESISTANCE PROTEIN OF STREPTOMYCES
		VENEZUELAE. [Bacillus subtilis]
1288	39384711 (8985, 8986)	Novel Protein sim. GBank gi|1881738 (U89688) - myosin-I binding protein		UNCLASSIFIED	1003, 1010, 1031
		Acan125 [Acanthamoeba castellanil]
1289	95361506 (777, 778)	Novel Protein sim. GBank gi|188864 (M74027) - mucin [Homo sapiens]		UNCLASSIFIED	1004, 1006, 1020, 1022,
					1025, 1028, 1031, 1036,
					1046, 1055
1290	79863655 (3087, 3088)	Novel Protein sim. GBank gi|1890588|emb|CAB01936| - (Z79692) ExpE3		UNCLASSIFIED	1010
		[Sinorhizobium meliloti]
1291	10234146 (8001, 8002)	Novel Protein sim. GBank gi|1929089|emb|CAB07817| - (Z93777)		UNCLASSIFIED	1036
		hypothetical protein Rv1215c [Mycobacterium tuberculosis]
1292	16299709 (8525, 8526)	Novel Protein sim. GBank gi|1934732 (U96128) - UDP-galactopyranose		UNCLASSIFIED	1022
		mutase [Mycobacterium tuberculosis]
1293	32338166 (5339, 5340)	Novel Protein sim. GBank gi|1934826|emb|CAB07947| - (Z93938)		UNCLASSIFIED	1026
		unknown [Bacillus subtilis]
1294	11615487 (6413, 6414)	Novel Protein sim. GBank gi|2055394 (U87306) - transmembrane		UNCLASSIFIED	1022
		receptor UNC5H2 [Rattus norvegicus]
1295	20414023 (6547, 6548)	Novel Protein sim. GBank gi|2072667|emb|CAB08319| - (Z95120)		UNCLASSIFIED	1008
		hypothetical protein Rv3218 [Mycobacterium tuberculosis]
1296	80252586 (2699, 2700)	Novel Protein sim. GBank gi|2072679|emb|CAB08310| - (Z95120) moeZ		UNCLASSIFIED	1022, 1050
		[Mycobacterium tuberculosis]
1297	35009859 (3043, 3044)	Novel Protein sim. GBank gi|2072958 (U93567) - putative p150 [Homo		UNCLASSIFIED	1035
		sapiens]
1298	10330910 (211, 212)	Novel Protein sim. GBank gi|2072961 (U93568) - putative p150 [Homo		UNCLASSIFIED	1035
		sapiens]
1299	65674732 (8893, 8894)	Novel Protein sim. GBank gi|2072967 (U93570) - putative p150 [Homo		UNCLASSIFIED	1014
		sapiens]
1300	29681887 (8987, 8988)	Novel Protein sim. GBank gi|2072967 (U93570) - putative p150 [Homo		UNCLASSIFIED	1007
		sapiens]
1301	80028197 (4431, 4432)	Novel Protein sim. GBank gi|2078483 (U43200) - antifreeze glycopeptide		UNCLASSIFIED	1004, 1007
		AFGP polyprotein precursor [Boreogadus saida]
1302	78462526 (8813, 8814)	Novel Protein sim. GBank gi|2088669 (AF003130) - F55A12.9 gene		UNCLASSIFIED	1006
		product [Caenorhabditis elegans]
1303	13084790 (7357, 7358)	Novel Protein sim. GBank gi|2094844|emb|CAB08571| - (Z95324) fba		UNCLASSIFIED	1025
		[Mycobacterium tuberculosis]
1304	39517709 (787, 788)	Novel Protein sim. GBank gi|2098748 (U94336) - oxidative stress		UNCLASSIFIED	1004
		transcriptional regulator, OxyR [Xanthomonas campestris]
1305	46661837 (3055, 3056)	Novel Protein sim. GBank gi|2104600|emb|CAB08809| - (Z95398)		UNCLASSIFIED	1037
		unknown [Mycobacterium leprae]
1306	14999136 (4983, 4984)	Novel Protein sim. GBank gi|2105069|emb|CAB08823| - (Z95436) mesJ		UNCLASSIFIED	1022
		[Mycobacterium tuberculosis]
1307	78749845 (1875, 1876)	Novel Protein sim. GBank gi|2105134 (U64984) - unknown		UNCLASSIFIED	1024
		[Bacteriophage Mx8]
1308	27227955 (4661, 4662)	Novel Protein sim. GBank gi|2114014|emb|CAB08963| - (Z95558)		UNCLASSIFIED	1020
		hypothetical protein Rv0552 [Mycobacterium tuberculosis]
1309	32728669 (4135, 4136)	Novel Protein sim. GBank gi|2114425 (U92466) - similar to Synechocystis		UNCLASSIFIED	1001
		sp. hypothetical protein, encoded by GenBank Accession Number
		D64006 [Bacillus subtilis]
1310	79457145 (1527, 1528)	Novel Protein sim. GBank gi|2117195|emb|CAB09016| - (Z95584)		UNCLASSIFIED	1028
		hypothetical protein Rv1157c [Mycobacterium tuberculosis]
1311	80428870 (4677, 4678)	Novel Protein sim. GBank gi|2117275|emb|CAB09104| - (Z95618)		UNCLASSIFIED	1008, 1020, 1021, 1024,
		hypothetical protein Rv0807 [Mycobacterium tuberculosis]			1031, 1035
1312	80019922 (4561, 4562)	Novel Protein sim. GBank gi|2119159|pir||I50694 - alpha-1 collagen type		UNCLASSIFIED	1020
		III - chicken (fragment)
1313	66726833 (8117, 8118)	Novel Protein sim. GBank gi|2127477|pir||JC5158 - cell division protein		UNCLASSIFIED	1007
		ftsX - Mycobacterium tuberculosis
1314	71773040 (281, 282)	Novel Protein sim. GBank gi|2129099|pir||G64413 - magnesium-chelatase		UNCLASSIFIED	1024, 1026
		homolog - Methanococcus jannaschii
1315	30808488 (421, 422)	Novel Protein sim. GBank gi|2129099|pir||G64413 - magnesium-chelatase		UNCLASSIFIED	1024
		homolog - Methanococcus jannaschii
1316	56513041 (4419, 4420)	Novel Protein sim. GBank gi|2129478|pir||S51939 - chitinase (EC		UNCLASSIFIED	1008
		3.2.1.14) precursor - beet
1317	16534688 (7675, 7676)	Novel Protein sim. GBank gi|2129478|pir||S51939 - chitinase (EC		UNCLASSIFIED	1006
		3.2.1.14) precursor - beet
1318	78735025 (6727, 6728)	Novel Protein sim. GBank gi|2131321|pir||S67592 - hypothetical protein		UNCLASSIFIED	1015
		YDL057w - yeast (Saccharomyces cerevisiae)
1319	80230507 (7889, 7890)	Novel Protein sim. GBank gi|2131351|pir||S61051 - hypothetical protein		UNCLASSIFIED	1001, 1003, 1004, 1006,
		YDL162c - yeast (Saccharomyces cerevisiae)			1015
1320	78786516 (3383, 3384)	Novel Protein sim. GBank gi|2131456|pir||S61174 - hypothetical protein		UNCLASSIFIED	1020
		YDR379w - yeast (Saccharomyces cerevisiae)
1321	38863784 (2647, 2648)	Novel Protein sim. GBank gi|2131833|pir||S69863 - hypothetical protein		UNCLASSIFIED	1020, 1021
		YMR031w-a - yeast (Saccharomyces cerevisiae)
1322	27963711 (8977, 8978)	Novel Protein sim. GBank gi|2131997|pir||S66717 - hypothetical protein		UNCLASSIFIED	1008, 1020, 1028, 1031
		YOL034w - yeast (Saccharomyces cerevisiae)
1323	79110964 (7745, 7746)	Novel Protein sim. GBank gi|2132008|pir||S66765 - hypothetical protein		UNCLASSIFIED	1014, 1041
		YOL072w - yeast (Saccharomyces cerevisiae)
1324	56148277 (3429, 3430)	Novel Protein sim. GBank gi|2132066|pir||S60988 - hypothetical protein		UNCLASSIFIED	1002, 1004, 1008, 1015,
		YOR134w - yeast (Saccharomyces cerevisiae)			1020, 1031
1325	29347669 (8463, 8464)	Novel Protein sim. GBank gi|2132143|pir||S67284 - hypothetical protein		UNCLASSIFIED	1020
		YOR372c - yeast (Saccharomyces cerevisiae)
1326	78726739 (8763, 8764)	Novel Protein sim. GBank gi|2132164|pir||S62027 - hypothetical protein		UNCLASSIFIED	1006, 1020, 1024
		YPL049c - yeast (Saccharomyces cerevisiae)
1327	27354572 (8691, 8692)	Novel Protein sim. GBank gi|2132245|pir||S61019 - hypothetical protein		UNCLASSIFIED	1007
		YPL245w - yeast (Saccharomyces cerevisiae)
1328	39434995 (7629, 7630)	Novel Protein sim. GBank gi|2132312|pir||S59829 - hypothetical protein		UNCLASSIFIED	1004, 1008, 1020, 1022,
		YPR171w - yeast (Saccharomyces cerevisiae)			1025, 1035, 1041
1329	24114486 (587, 588)	Novel Protein sim. GBank gi|2132393|pir||S64015 - pleiotropic drug		UNCLASSIFIED	1024
		resistance control protein PDR1 - yeast (Saccharomyces cerevisiae)
1330	78788035 (3725, 3726)	Novel Protein sim. GBank gi|2132466|pir||S67803 - probable membrane		UNCLASSIFIED	1020
		protein YDL239c - yeast (Saccharomyces cerevisiae)
1331	39707435 (7093, 7094)	Novel Protein sim. GBank gi|2132683|pir||S64851 - probable membrane		UNCLASSIFIED	1006
		protein YLR024c - yeast (Saccharomyces cerevisiae)
1332	80218401 (7901, 7902)	Novel Protein sim. GBank gi|2132663|pir||S64851 - probable membrane		UNCLASSIFIED	1004, 1020, 1022
		protein YLR024c - yeast (Saccharomyces cerevisiae)
1333	71793849 (6481, 6482)	Novel Protein sim. GBank gi|2132828|pir||S66714 - probable membrane		UNCLASSIFIED	1007
		protein YOL031c - yeast (Saccharomyces cerevisiae)
1334	80250262 (4717, 4718)	Novel Protein sim. GBank gi|2132934|pir||S67175 - probable membrane		UNCLASSIFIED	1004
		protein YOR273c - yeast (Saccharomyces cerevisiae)
1335	27847010 (6575, 6576)	Novel Protein sim. GBank gi|2132957|pir||S67290 - probable membrane		UNCLASSIFIED	1003, 1022, 1031
		protein YOR378w - yeast (Saccharomyces cerevisiae)
1336	39568617 (7661, 7662)	Novel Protein sim. GBank gi|2133032|pir||S69034 - probable membrane		UNCLASSIFIED	1003, 1004
		protein YPR147c - yeast (Saccharomyces cerevisiae)
1337	78728781 (7257, 7258)	Novel Protein sim. GBank gi|2133036|pir||S59823 - probable membrane		UNCLASSIFIED	1006
		protein YPR164w - yeast (Saccharomyces cerevisiae)
1338	80243781 (4587, 4588)	Novel Protein sim. GBank gi|2135121|pir||A49674 - flightless-I homolog -		UNCLASSIFIED	1004
		human (fragment)
1339	79572341 (5883, 5884)	Novel Protein sim. GBank gi|2135847|pir||I59234 - octamer binding		UNCLASSIFIED	1015
		transcription factor 1 - human
1340	79161087 (5527, 5528)	Novel Protein sim. GBank gi|2137044|pir||I46884 - unknown protein -		UNCLASSIFIED	1003
		rabbit (fragment)
1341	17244419 (275, 276)	Novel Protein sim. GBank gi|2143868|pir||I59402 - NAB1 - rat		UNCLASSIFIED	1015, 1022
1342	37804391 (723, 724)	Novel Protein sim. GBank gi|2144012|pir||S70642 - ubiquitin ligase Nedd4 -		UNCLASSIFIED	1055
		rat (fragment)
1343	78381454 (4043, 4044)	Novel Protein sim. GBank gi|2181972|emb|CAB09492| - (Z96072)		UNCLASSIFIED	1024, 1026
		hypothetical protein Rv2681 [Mycobacterium tuberculosis]
1344	78675426 (7225, 7226)	Novel Protein sim. GBank gi|218496|dbj|BAA02301| - (D12917) a		UNCLASSIFIED	1015
		component of the pheromone signal transduction pathway
		[Saccharomyces cerevisiae]
1345	13085101 (4089, 4090)	Novel Protein sim. GBank gi|2191127 (AF007269) - A_IG002N01.1 gene		UNCLASSIFIED	1022
		product [Arabidopsis thaliana)
1346	78490869 (7829, 7830)	Novel Protein sim. GBank gi|2193870|dbj|BAA204191 - (D84391) reverse		UNCLASSIFIED	1027
		transcriptase [Mus musculus]
1347	20758023 (6551, 6552)	Novel Protein sim. GBank gi|2193927|emb|CA809594| - (Z96800)		UNCLASSIFIED	1020
		hypothetical protein Rv0306 [Mycobacterium tuberculosis]
1348	70287245 (1277, 1278)	Novel Protein sim. GBank gi|2213518|emb|CAB09748| - (Z97050)		UNCLASSIFIED	1007
		hypothetical protein Rv0181c [Mycobacterium tuberculosis]
1349	20474010 (5945, 5946)	Novel Protein sim. GBank gi|2222715|emb|CAB09911| - (Z97179)		UNCLASSIFIED	1008
		hypothetical protein MLCL383.37 [Mycobacterium leprae]
1350	46860900 (4549, 4550)	Novel Protein sim. GBank gi|2224699|dbj|BAA20833| - (AB002377)		UNCLASSIFIED	1051
		KIAA0379 [Homo sapiens]
1351	39731041 (5035, 5036)	Novel Protein sim. GBank gi|2224832|emb|CAB10018| - (Z97188)		UNCLASSIFIED	1024
		hypothetical protein Rv3813c [Mycobacterium tuberculosis]
1352	79464102 (7891, 7892)	Novel Protein sim. GBank gi|2225947|emb|CAB10053| - (Z97193)		UNCLASSIFIED	1025, 1026, 1041
		hypothetical protein Rv1913 [Mycobacterium tuberculosis]
1353	79427160 (625, 626)	Novel Protein sim. GBank gi|2232045 (U97516) - rubisco operon		UNCLASSIFIED	1015
		transcriptional regulator [Synechococcus PCC7002]
1354	25251803 (5705, 5706)	Novel Protein sim. GBank gi|2243022|dbj|BAA21086| - (AB004855)		UNCLASSIFIED	1006, 1024
		inhibition of morphological differentiation [Streptomyces cyaneus]
1355	9678386 (4003, 4004)	Novel Protein sim. GBank gi|2244683|emb|CAA69113| - (Y07786)		UNCLASSIFIED	1041
		ORF43x9 [Vibrio cholerae]
1356	79844068 (951, 952)	Novel Protein sim. GBank gi|225047|prf||1207289A - reverse		UNCLASSIFIED	1041
		transcriptase related protein [Homo sapiens]
1357	19755599 (7159, 7160)	Novel Protein sim. GBank gi|2253054|emb‥CAB10705| - (Z97559)		UNCLASSIFIED	1001
		hypothetical protein Rv2114 [Mycobacterium tuberculosis]
1358	88094659 (4297, 4298)	Novel Protein sim. GBank gi|2293165 (AF008220) - asparagine synthase		UNCLASSIFIED	1008
		[Bacillus subtilis]
1359	17903910 (3963, 3964)	Novel Protein sim. GBank gi|2293566 (AF012896) - ADP-ribosylation		UNCLASSIFIED	1006, 1051
		factor 1 [Oryza sativa]
1360	13883880 (3325, 3326)	Novel Protein sim. GBank gi|2314239|gb|AAD08134.1| - (AE000615) H.		UNCLASSIFIED	1050
		pylori predicted coding region HP1083 [Helicobacter pylori 26695]
1361	85518681 (6517, 6518)	Novel Protein sim. GBank gi|2314416|gb|AAD08296.1| - (AE000630)		UNCLASSIFIED	1046
		oligopeptide ABC transporter, periplasmic oligopeptide-binding protein
		(oppA) [Helicobacter pylori 26695]
1362	3297187 (8955, 8956)	Novel Protein sim. GBank gi|2314862|gb|AAD08525.1| - (AE000647)		UNCLASSIFIED	1035, 1051
		conserved hypothetical protein [Helicobacter pylori 26695]
1363	81022707 (2111, 2112)	Novel Protein sim. GBank gi|2314688|gb|AAD08549.1| - (AE000649)		UNCLASSIFIED	1051
		conserved hypothetical ATP-binding protein [Helicobacter pylori 26695]
1364	66441044 (1705, 1706)	Novel Protein sim. GBank gi|2317934 (U97553) - unknown [murine		UNCLASSIFIED	1002, 1020
		herpesvirus 68]
1365	29213316 (4671, 4672)	Novel Protein sim. GBank gi|2318062 (AF012532) - YeeB [Bacillus		UNCLASSIFIED	1024
		subtilis]
1366	79612771 (8435, 8436)	Novel Protein sim. GBank gi|2326752|emb|CAB10966| - (Z98268)		UNCLASSIFIED	1002
		hypothetical protein Rv1709 [Mycobacteilum tuberculosis]
1367	80071779 (1045, 1046)	Novel Protein sim. GBank gi|2326943|emb|CAA74576| - (Y14163) fizzy-		UNCLASSIFIED	1020
		related protein [Xenopus laevis]
1368	37003586 (957, 958)	Novel Protein sim. GBank gi|2337843|emb|CAB11337| - (Z98604)		UNCLASSIFIED	1026
		hypothetical protein MLCB2052.39 [Mycobacterium leprae]
1369	79172972 (6663, 6664)	Novel Protein sim. GBank gi|2342601|emb|CAA61605| - (X89442) peptide		UNCLASSIFIED	1028
		synthetase [Metarhizium anisopliae]
1370	80062689 (5537, 5538)	Novel Protein sim. GBank gi|2342612|emb|CAB11383| - (Z98741)		UNCLASSIFIED	1008, 1031
		hypothetical protein MLCB22.18 [Mycobacterium leprae]
1371	17294715 (3659, 3660)	Novel Protein sim. GBank gi|2351849 (U93357) - 40 kDa heat shock		UNCLASSIFIED	1036
		chaperone protein [Halobacterium cutirubrum]
1372	13085422 (5511, 5512)	Novel Protein sim. GBank gi|238781|bbs|65093 - (S65091) cyclic AMp-		UNCLASSIFIED	1025
		regulated phosphoprotein, ARPP-21 [rats, Peptide, 88 aa] [Rattus sp.]
1373	78470366 (3669, 3670)	Novel Protein sim. GBank gi|2435511 (AF024504) - contains similarity to		UNCLASSIFIED	1024
		prolyl 4-hydroxylase alpha subunit [Arabidopsis thaliana]
1374	80496730 (1323, 1324)	Novel Protein sim. GBank gi|244239|bbs|78626 - (S78624) YCR592		UNCLASSIFIED	1002, 1010, 1020, 1031,
		[Saccharomyces cerevisiae=yeast, Peptide, 1226 aa] [Saccharomyces			1041
		cerevisiae]
1375	9403089 (1085, 1086)	Novel Protein sim. GBank gi|2459978 (AF010150) - PcrD [Pseudomonas		UNCLASSIFIED	1041
		aeruginosa]
1376	27240528 (6889, 6890)	Novel Protein sim. GBank gi|2464905|emb|CAB16805.1| - (Z99708) minor		UNCLASSIFIED	1041
		allergen [Arabidopsis thaliana]
1377	80483956 (1689, 1690)	Novel Protein sim. GBank gi|2492588|sp|Q50734|YOA4_MYCTU -		UNCLASSIFIED	1010
		HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN
		CY9C4.04C
1378	17947584 (2285, 2286)	Novel Protein sim. GBank gi|2492885|sp|P77495|PRPE_ECOLI - PRPE		UNCLASSIFIED	1001
		PROTEIN
1379	47652732 (5123, 5124)	Novel Protein sim. GBank gi|2492983|sp|P94556|MURI_BACSU -		UNCLASSIFIED	1026
		GLUTAMATE RACEMASE
1380	33204977 (7297, 7298)	Novel Protein sim. GBank gi|2494548|sp|Q51463|FLIF_PSEAE -		UNCLASSIFIED	1024
		FLAGELLAR M-RING PROTEIN
1381	20100736 (3053, 3054)	Novel Protein sim. GBank gi|2495183|sp|Q51887|HEMX_PROMI -		UNCLASSIFIED	1008
		PUTATIVE UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN
		III METHYLASE)
1382	27804781 (1039, 1040)	Novel Protein sim. GBank gi|2496226|sp|Q60283|YZ24_METJA -		UNCLASSIFIED	1022
		HYPOTHETICAL PROTEIN MJECL24
1383	11102283 (1157, 1158)	Novel Protein sim. GBank gi|2496709|sp|P55564|Y4ME_RHISN -		UNCLASSIFIED	1004
		HYPOTHETICAL 45.7 KD PROTEIN Y4ME
1384	87112445 (2521, 2522)	Novel Protein sim. GBank gi|2497117|sp|Q03690|IF31_YEAST -		UNCLASSIFIED	1020, 1035
		EUKARYOTIC TRANSLATION INITIATION FACTOR 3 ALPHA SUBUNIT
		(EIF-3 ALPHA) (EIF3 P135) (TRANSLATION INITIATION FACTOR EIF3,
		P135 SUBUNIT)
1385	65686809 (599, 600)	Novel Protein sim. GBank gi|2497183|sp|Q04336|YM54_YEAST -		UNCLASSIFIED	1000, 1008
		HYPOTHETICAL 126.6 KD PROTEIN IN RPL39-VTI1 INTERGENIC
		REGION
1386	27788025 (709, 710)	Novel Protein sim. GBank gi|2497191|sp|Q03660|YM66_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 128.1 KD PROTEIN IN GUA1-ERG8 INTERGENIC
		REGION
1387	80053984 (8333, 8334)	Novel Protein sim. GBank gi|2497281|sp|P72689|IF2_SYNY3 -		UNCLASSIFIED	1008
		TRANSLATION INITIATION FACTOR IF-2
1388	80233293 (3655, 3656)	Novel Protein sim. GBank gi|2498298|sp|Q12387|DEC1_YEAST - DEC1		UNCLASSIFIED	1006, 1007, 1008, 1015,
		PROTEIN (MDM20 PROTEIN)			1020, 1023
1389	28375903 (7607, 7608)	Novel Protein sim. GBank gi|2498506|sp|Q12446|LA17_YEAST -		UNCLASSIFIED	1041
		PROLINE-RICH PROTEIN LAS17
1390	10063089 (3741, 3742)	Novel Protein sim. GBank gi|2498598|sp|Q59650|MURE_PSEAE - UDP-		UNCLASSIFIED	1015
		N-ACETYLMURAMOYLALANYL-D-GLUTAMATE-2.6-
		DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
		SYNTHETASE)
1391	66376623 (4325, 4326)	Novel Protein sim. GBank gi|2500969|sp|Q50649|SYD_MYCTU -		UNCLASSIFIED	1007
		ASPARTYL-TRNA SYNTHETASE (ASPARTATE-TRNA LIGASE)
		(ASPRS)
1392	80046707 (8683, 8684)	Novel Protein sim. GBank gi|2500970|sp|Q51422|SYD_PSEAE -		UNCLASSIFIED	1022
		ASPARTYL-TRNA SYNTHETASE (ASPARTATE-TRNA LIGASE)
		(ASPRS)
1393	80062922 (7659, 7660)	Novel Protein sim. GBank gi|2501040|sp|O05814|SYP_MYCTU -		UNCLASSIFIED	1020, 1022
		PROLYL-TRNA SYNTHETASE (PROLINE-TRNA LIGASE) (PRORS)
1394	80583862 (8649, 8650)	Novel Protein sim. GBank gi|2501190|sp|Q41739|TH42_MAIZE -		UNCLASSIFIED	1007, 1020, 1024, 1028,
		THIAMINE BIOSYNTHETIC ENZYME 1-2 PRECURSOR			1047, 1055
1395	79826267 (7283, 7284)	Novel Protein sim. GBank gi|2501603|sp|Q08647|YO43_YEAST -		UNCLASSIFIED	1041
		HYPOTHETICAL 77.0 KD PROTEIN IN HES1-SEC63 INTERGENIC
		REGION
1396	79406465 (8645, 8646)	Novel Protein sim. GBank gi|2506592|sp|P45568|DXR_ECOLI - 1-DEOXY		UNCLASSIFIED	1014, 1028
		D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXP
		REDUCTOISOMERASE)
1397	39550271 (2023, 2024)	Novel Protein sim. GBank gi|2507103|sp|P43670|PQIA_ECOLI		UNCLASSIFIED	1036
		PARAQUAT-INDUCIBLE PROTEIN A
1398	78463315 (2237, 2238)	Novel Protein sim. GBank gi|2507510|sp|P39173|UP08_ECOLI -		UNCLASSIFIED	1006
		UNKNOWN PROTEIN FROM 2D-PAGE (SPOTS T26/PR37)
1399	36622848 (1071, 1072)	Novel Protein sim. GBank gi|2507513|sp|P53088|YGW1_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 35.5 KD PROTEIN IN VAM7-YPT32 INTERGENIC
		REGION
1400	71088713 (8831, 8832)	Novel Protein sim. GBank gi|2578381|emb|CAA15466| - (AL008609)		UNCLASSIFIED	1050
		hypothetical protein MLCB1788.34c [Mycobacterium leprae]
1401	77588758 (5547, 5548)	Novel Protein sim. GBank gi|2582422|gb|AAB82564.1| - (AF026067)		UNCLASSIFIED	1046
		FMNH2-dependent methanesulfonate sulfonatase [Pseudomonas
		aeruginosa]
1402	10146972 (8081, 8082)	Novel Protein sim. GBank gi|2589196 (AF008553) - Glu-tRNAGln		UNCLASSIFIED	1051
		amidotransferase subunit B [Bacillus subtilis]
1403	79264251 (4757, 4758)	Novel Protein sim. GBank gi|2598593|emb|CAA75591| - (Y15369) MtNI2		UNCLASSIFIED	1022
		[Medicago truncatula]
1404	80081087 (1937, 1938)	Novel Protein sim. GBank gi|2612821|emb|CAA04438| - (AJ000978)		UNCLASSIFIED	1031, 1041
		cis/trans isomerase [Pseudomonas putida]
1405	85518697 (2667, 2668)	Novel Protein sim. GBank gi|2619029 (AF027868) - YoaR [Bacillus		UNCLASSIFIED	1046
		subtilis]
1406	20736837 (8453, 8454)	Novel Protein sim. GBank gi|2623258 (AF030941) - putative secreted		UNCLASSIFIED	1020
		protein [Neisseria meningitidis]
1407	11077011 (999, 1000)	Novel Protein sim. GBank gi|2632098|emb|CAA75667| - (Y15513) Prodos		UNCLASSIFIED	1020
		protein [Drosophila melanogaster]
1408	9860215 (6187, 6188)	Novel Protein sim. GBank gi|2635771|emb|CAB15264| - (Z99120) similar		UNCLASSIFIED	1006
		to ABC transporter (ATP-binding protein) [Bacillus subtilis]
1409	9742433 (8019, 8020)	Novel Protein sim. GBank gi|2645674 (AF031955) - krupple-related zinc		UNCLASSIFIED	1036
		finger protein [Mus musculus]
1410	20729461 (2545, 2546)	Novel Protein sim. GBank gi|2648206 (AE000944) - maoC protein (maoC)		UNCLASSIFIED	1004
		[Archaeoglobus fulgidus]
1411	27977651 (7001, 7002)	Novel Protein sim. GBank gi|2649977 (AE001060) - conserved		UNCLASSIFIED	1004
		hypothetical protein [Archaeoglobus fulgidus]
1412	65898533 (3967, 3968)	Novel Protein sim. GBank gi|2661679|emb|CAA15784| - (AL009199)		UNCLASSIFIED	1014
		probable transmembrane transport protein [Streptomyces coelicolor]
1413	79110032 (843, 844)	Novel Protein sim. GBank gi|2661689|emb|CAA15793| - (AL009204) DNA		UNCLASSIFIED	1008, 1041
		gyrase-like protein [Streptomyces coelicolor]
1414	65668313 (6823, 6824)	Novel Protein sim. GBank gi|2661697|emb|CAA15801| - (AL009204)		UNCLASSIFIED	1014
		hypothetical protein SC9B10.11 [Streptomyces coelicolor]
1415	79574554 (8397, 8398)	Novel Protein sim. GBank gi|2661708|emb|CAA15812| - (AL009204)		UNCLASSIFIED	1028
		hypothetical protein SC9B10.22c [Streptomyces coelicolor]
1416	78386939 (3995, 3998)	Novel Protein sim. GBank gi|2661711|emb|CAA15815| - (AL00920.4)		UNCLASSIFIED	1006
		hypothetical protein SC9B10.25c [Streptomyces coelicolor]
1417	27354547 (3889, 3870)	Novel Protein sim. GBank gi|2673908 (AC002561) - hypothetical protein		UNCLASSIFIED	1024
		[Arabidopsis thaliana]
1418	17931585 (217, 218)	Novel Protein sim. GBank gi|2723362 (AF023459) - lustrin A [Hallotis		UNCLASSIFIED	1002
		rufescens]
1419	78763436 (3677, 3678)	Novel Protein sim. GBank gi|2760121|dbj|BAA24179| - (AB002405) LAK-		UNCLASSIFIED	1015, 1020
		4p [Homo sapiens]
1420	38069985 (5501, 5502)	Novel Protein sim. GBank gi|2791626|emb|CAA16113.1| - (AL021287)		UNCLASSIFIED	1014
		fixB [Mycobacterium tuberculosis]
1421	20753533 (4749, 4750)	Novel Protein sim. GBank gi|2791647|emb|CAA16134.1| - (AL021287)		UNCLASSIFIED	1003
		hypothetical protein Rv3049c [Mycobacterium tuberculosis]
1422	11090532 (6973, 6974)	Novel Protein sim. GBank gi|2811058|sp|O07931|YRAM_BACSU -		UNCLASSIFIED	1004
		HYPOTHETICAL 39.5 KD PROTEIN IN SIGZ-CSN INTERGENIC
		REGION
1423	17299877 (3883, 3884)	Novel Protein sim. GBank gi|2828673|gb|AAC00183.1| - (AF038816)		UNCLASSIFIED	1036
		WbbK [Serratia marcescens]
1424	11615829 (1935, 1936)	Novel Protein sim. GBank gi|283032|pir||S22456 - hydroxyproline-rich		UNCLASSIFIED	1014
		glycoprotein - perennial teosinte
1425	27368323 (2157, 2158)	Novel Protein sim. GBank gi|2833204|sp|Q06063|YL05_YEAST -		UNCLASSIFIED	1015, 1021
		HYPOTHETICAL 41.7 KD PROTEIN IN SFP1-CTR3 INTERGENIC
		REGION
1426	27981996 (7329, 7330)	Novel Protein sim. GBank gi|2851439|sp|P27851|UBIE_ECOLI -		UNCLASSIFIED	1004
		UBIQUINONE/MENAQUINONE BIOSYNTHESIS
		METHLYTRANSFERASE UBIE
1427	10371060 (7665, 7666)	Novel Protein sim. GBank gi|2851589|sp|P42616|YQJC_ECOLI -		UNCLASSIFIED	1055
		HYPOTHETICAL 14.5 KD PROTEIN IN EXUR-TDCC INTERGENIC
		REGION PRECURSOR
1428	79810756 (5713, 5714)	Novel Protein sim. GBank gi|2853603 (AF031898) - MotB [Pseudomonas		UNCLASSIFIED	1002
		putida]
1429	80085671 (5087, 5088)	Novel Protein sim. GBank gi|2887423|dbj|BAA24854| - (AB007884)		UNCLASSIFIED	1051
		KIAA0424 [Homo sapiens]
1430	35106788 (1635, 1636)	Novel Protein sim. GBank gi|2894186|emb|CAA11792.1| - (AJ223999)		UNCLASSIFIED	1024
		PCZA363.1 [Amycolatopsis orientalis]
1431	80496412 (4949, 4950)	Novel Protein sim. GBank gi|2894206|emb|CAA17072| - (AL021840)		UNCLASSIFIED	1010
		hypothetical protein Rv3258c [Mycobacterium tuberculosis]
1432	17942491 (3519, 3520)	Novel Protein sim. GBank gi|2895756 (AF045160) - hypoxia-inducible		UNCLASSIFIED	1022
		factor 1 alpha related factor [Mus musculus]
1433	80504037 (8703, 8704)	Novel Protein sim. GBank gi|2896688|emb|CAA17167.1| - (AL021897)		UNCLASSIFIED	1010
		hypothetical protein Rv1051c [Mycobacterium tuberculosis]
1434	79574675 (6943, 6944)	Novel Protein sim. GBank gi|2909479|emb|CAA17365| - (AL021930)		UNCLASSIFIED	1028
		hypothetical protein Rv0290 [Mycobacterium tuberculosis]
1435	80200576 (6013, 6014)	Novel Protein sim. GBank gi|2911274 (U20329) - spidroin 1 [Nephila		UNCLASSIFIED	1001, 1031, 1035
		clavipes]
1436	37402674 (141, 142)	Novel Protein sim. GBank gi|2911858 (AF047659) - No definition line		UNCLASSIFIED	1020
		found [Caenorhabditis elegans]
1437	25260874 (1769, 1770)	Novel Protein sim. GBank gi|2916883|emb|CAA17631.1| - (AL022004)		UNCLASSIFIED	1024
		hypothetical protein Rv0825c [Mycobacterium tuberculosis]
1438	9846771 (2205, 2206)	Novel Protein sim. GBank gi|2921304 (AF033496) - herbicide safener		UNCLASSIFIED	1021
		binding protein [Zea mays]
1439	13076513(1409, 1410)	Novel Protein sim. GBank gi|2960090|emb|CAA17988.1| - (AL022121)		UNCLASSIFIED	1022
		dppA [Mycobacterium tuberculosis]
1440	65486872 (4407, 4408)	Novel Protein sim. GBank gi|2960108|emb|CAA18006.1| - (AL022121)		UNCLASSIFIED	1021
		hypothetical protein Rv3684 [Mycobacterium tuberculosis]
1441	10858270 (5325, 5326)	Novel Protein sim. GBank gi|2960127|emb|CAA18025.1| - (AL022121)		UNCLASSIFIED	1028
		hypothetical protein Rv3703c [Mycobacterium tuberculosis]
1442	16495698 (2777, 2778)	Novel Protein sim. GBank gi|2961293|emb|CAA12353| - (AJ225023)		UNCLASSIFIED	1006
		RagC [Bradyrhizobium japonicum]
1443	27848380 (1733, 1734)	Novel Protein sim. GBank gi|2970646 (AF051945) - Xin [Mus musculus]		UNCLASSIFIED	1003
1444	10284821 (4781, 4782)	Novel Protein sim. GBank gi|2970646 (AF051945) - Xin [Mus musculus]		UNCLASSIFIED	1001
1445	86380205 (6115, 6116)	Novel Protein sim. GBank gi|2978255|dbj|BAA25190| - (AB007407)		UNCLASSIFIED	1050
		myeloid zinc finger protein-2 [Mus musculus]
1446	80232365 (4711, 4712)	Novel Protein sim. GBank gi|2978511 (AF006988) - septin [Homo		UNCLASSIFIED	1050
		sapiens]
1447	30783668 (7729, 7730)	Novel Protein sim. GBank gi|2981043 (AF051690) - iron-uptake factor		UNCLASSIFIED	1002
		[Pseudomonas aeruginosa]
1448	30499026 (885, 886)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		UNCLASSIFIED	1006
		ORF2 [Canis familiaris]
1449	17957450 (8045, 8046)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		UNCLASSIFIED	1002
		ORF2 [Canis familiaris]
1450	20292199 (4327, 4328)	Novel Protein sim. GBank gi|2982903 (AE000677) - glycerol-3-phosphate		UNCLASSIFIED	1031
		cytidyltransferase [Aquifex aeolicus]
1451	79562520 (2689, 2690)	Novel Protein sim. GBank gi|2982968 (AE000681) - RNA		UNCLASSIFIED	1021
		methyltransferase (TrmA-family) [Aqulfex aeolicus]
1452	65472169 (4633, 4634)	Novel Protein sim. GBank gi|2983901 (AE000744) - putative protein		UNCLASSIFIED	1046
		[Aquifex aeolicus]
1453	25263548 (3419, 3420)	Novel Protein sim. GBank gi|2995352|emb|CAA04606.1| - (AJ001206)		UNCLASSIFIED	1024
		pep1 [Streptomyces coelicolor]
1454	94238497 (4119, 4120)	Novel Protein sim. GBank gi|2995645 (AF051092) - restriction		UNCLASSIFIED	1008
		endonuclease R.Xbal [Xanthomonas campestris]
1455	56511449 (5681, 5682)	Novel Protein sim. GBank gi|3002588 (AF030131) - Plenty of SH3s;		UNCLASSIFIED	1046
		POSH [Mus musculus]
1456	19882009 (8979, 8980)	Novel Protein sim. GBank gi|3024402|sp|P77349|PHOL_ECOLI - PHOH-		UNCLASSIFIED	1031
		LIKE PROTEIN
1457	86475949 (6909, 6910)	Novel Protein sim. GBank gi|3025003|sp|P75770|YBHN_ECOLI -		UNCLASSIFIED	1026
		HYPOTHETICAL 35.9 KD PROTEIN IN MOAE-RHLE INTERGENIC
		REGION
1458	20457025 (1665, 1666)	Novel Protein sim. GBank gi|3025051|sp|P75870|YCCS_ECOLI -		UNCLASSIFIED	1008
		HYPOTHETICAL 82.0 KD PROTEIN IN SULA-HELD INTERGENIC
		REGION
1459	20456994 (6747, 6748)	Novel Protein sim. GBank gi|3025051|sp|P75870|YCCS_ECOLI -		UNCLASSIFIED	1008
		HYPOTHETICAL 82.0 KD PROTEIN IN SULA-HELD INTERGENIC
		REGION
1460	11695106 (8933, 8934)	Novel Protein sim. GBank gi|3025274|sp|P77751|YPHA_ECOLI -		UNCLASSIFIED	1004
		HYPOTHETICAL 17.9 KD PROTEIN IN CSIE-GLYA INTERGENIC
		REGION
1461	80232553 (3517, 3518)	Novel Protein sim. GBank gi|3025276|sp|Q02981|YP09_YEAST -		UNCLASSIFIED	1003, 1004, 1008, 1015,
		HYPOTHETICAL 62.8 KD PROTEIN IN SSE1-CAR1 INTERGENIC			1020, 1026, 1031, 1035,
		REGION			1041
1462	5647321 (5109, 5110)	Novel Protein sim. GBank gi|3043744|dbj|BAA25536| - (AB011182)		UNCLASSIFIED	1055
		KIAA0610 protein [Homo sapiens]
1463	24120704 (8349, 8350)	Novel Protein sim. GBank gi|3063449 (AC003981) - F22O13.11		UNCLASSIFIED	1007
		[Arabidopsis thaliana]
1464	20416329 (6795, 6796)	Novel Protein sim. GBank gi|3080499|emb|CAA18696| - (AL022602)		UNCLASSIFIED	1003
		putative long chain fatty acid-coA ligase [Mycobacterium leprae]
1465	80067054 (4755, 4756)	Novel Protein sim. GBank gi|311121 (L03536) - PRP18 [Saccharomyces		UNCLASSIFIED	1002, 1003, 1006, 1007,
		cerevisiae]			1015, 1020, 1024, 1036,
					1041
1466	27212702 (5063, 5064)	Novel Protein sim. GBank gi|3122415|sp|Q55469|MURE_SYNY3 - UDP-N		UNCLASSIFIED	1007
		ACETYLMURAMOYLALANYL-D-GLUTAMATE -
		2,6-DIAMINOPIMELATE
		LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE)
1467	65494202 (3285, 3286)	Novel Protein sim. GBank gi|3122837|sp|O05885|SEA1_MYCTU -		UNCLASSIFIED	1021, 1051
		PREPROTEIN TRANSLOCASE SECA 1 SUBUNIT
1468	20446721 (6271, 6272)	Novel Protein sim. GBank gi|3122843|sp|O32922|SECA_MYCLE -		UNCLASSIFIED	1022
		PREPROTEIN TRANSLOCASE SECA SUBUNIT
1469	82125782 (5445, 5446)	Novel Protein sim. GBank gi|3122849|sp|P95759|SECA_STRGR -		UNCLASSIFIED	1008, 1010, 1014, 1022
		PREPROTEIN TRANSLOCASE SECA SUBUNIT
1470	80439990 (3093, 3094)	Novel Protein sim. GBank gi|3122893|sp|P94985|SYFB_MYCTU -		UNCLASSIFIED	1015, 1035, 1041
		PHENYLALANYL-TRNA SYNTHETASE
		BETA CHAIN (PHENYLALANINE-
		TRNA LIGASE BETA CHAIN) (PHERS)
1471	39587457 (969, 970)	Novel Protein sim. GBank gi|3122932|sp|O32053|TGT_BACSU -		UNCLASSIFIED	1020
		QUEUINE TRNA-RIBOSYLTRANSFERASE (TRNA-GUANINE
		TRANSGLYCOSYLASE) (GUANINE INSERTION ENZYME)
1472	19893858 (6581, 6582)	Novel Protein sim. GBank gi|3122996|sp|O10685|VGLG_BRSV2 -		UNCLASSIFIED	1001
		MAJOR SURFACE GLYCOPROTEIN G (ATTACHMENT
		GLYCOPROTEIN G)
1473	66259118 (4425, 4426)	Novel Protein sim. GBank gi|3127080 (AF061070) - PtxD [Pseudomonas		UNCLASSIFIED	1008
		stutzeri]
1474	20369568 (8317, 8318)	Novel Protein sim. GBank gi|3128359 (AF010496) - ribose transport ATP-		UNCLASSIFIED	1003
		binding protein [Rhodobacter capsulatus]
1475	20711026 (7895, 7896)	Novel Protein sim. GBank gi|3128364 (AF010496) - potential 30S		UNCLASSIFIED	1004, 1006
		ribosomal protein S6 [Rhodobacter capsulatus]
1476	20466820 (503, 504)	Novel Protein sim. GBank gi|3157463|dbj|BAA28360| - (D85027) integral		UNCLASSIFIED	1008
		membrane protein [Thermus sp. A4]
1477	94143338 (1423, 1424)	Novel Protein sim. GBank gi|3170548|gb|AAC34395.1| - (AF056116)		UNCLASSIFIED	1002
		unknown [Fugu rubripes]
1478	30166162 (4803, 4804)	Novel Protein sim. GBank gi|3170548|gb|AAC34395.1| - (AF056116)		UNCLASSIFIED	1047
		unknown [Fugu rubripes]
1479	79105657 (2979, 2980)	Novel Protein sim. GBank gi|3183274|sp|O13725|YDO5_SCHPO -		UNCLASSIFIED	1036
		HYPOTHETICAL 26.5 KD PROTEIN C15A10.05C IN CHROMOSOME I
1480	21637936 (5685, 5686)	Novel Protein sim. GBank gi|3183977|emb|CAA39515| - (X56044) protein		UNCLASSIFIED	1031
		Htf9C [Mus musculus]
1481	13521386 (491, 492)	Novel Protein sim. GBank gi|3192726 (AF064539) - gp41 [Bacteriophage		UNCLASSIFIED	1022
		N15]
1482	37013703 (3735, 3736)	Novel Protein sim. GBank gi|3212854 (AC004005) - unknown protein		UNCLASSIFIED	1026
		[Arabidopsis thaliana]
1483	79824579 (3961, 3962)	Novel Protein sim. GBank gi|321861|pir||A45313 - putrescine transport		UNCLASSIFIED	1041
		protein potF - Escherichia coli
1484	78375747 (3803, 3804)	Novel Protein sim. GBank gi|3219913|sp|O14346|YB3G_SCHPO -		UNCLASSIFIED	1041
		HYPOTHETICAL PROTEIN C2F12.16 IN CHROMOSOME II
1485	66052048 (5579, 5580)	Novel Protein sim. GBank gi|3219995|sp|P37773|MPL_ECOLI - UDP-N-		UNCLASSIFIED	1031, 1046
		ACETYLMURAMATE: L-ALANYL-GAMMA-D-GLUTAMYL-MESO-
		DIAMINOPIMELATE LIGASE
1486	25251251 (2669, 2670)	Novel Protein sim. GBank gi|3241940 (AC004625) - unknown protein		UNCLASSIFIED	1021
		[Arabidopsis thaliana]
1487	13069230 (4851, 4852)	Novel Protein sim. GBank gi|3242273|emb|CAB07017| - (Z92669)		UNCLASSIFIED	1022
		hypothetical protein Rv0236c [Mycobacterium tuberculosis]
1488	79319174 (1081, 1082)	Novel Protein sim. GBank gi|3242290|emb|CAA17283| - (AL021922)		UNCLASSIFIED	1004, 1022
		cobN [Mycobacterium tuberculosis]
1489	25310369 (279, 280)	Novel Protein sim. GBank gi|3253199 (AF029714) - PhaC [Pseudomonas		UNCLASSIFIED	1007
		putida]
1490	80503659 (7965, 7966)	Novel Protein sim. GBank gi|3261502|emb|CAA16010| - (AL021184)		UNCLASSIFIED	1010
		hypothetical protein Rv1480 [Mycobacterium tuberculosis]
1491	20466305 (8043, 8044)	Novel Protein sim. GBank gi|3261721|emb|CAB07057| - (Z92770)		UNCLASSIFIED	1008
		hypothetical protein Rv0153c [Mycobacterium tuberculosis]
1492	81830943 (4045, 4046)	Novel Protein sim. GBank gi|3261746|emb|CAB08449| - (Z95207) nusA		UNCLASSIFIED	1051
		[Mycobacterium tuberculosis]
1493	8018637 (4631, 4632)	Novel Protein sim. GBank gi|3261799|emb|CAB09571| - (Z96796)		UNCLASSIFIED	1031
		hypothetical protein Rv0457c [Mycobacterium tuberculosis]
1494	86477555 (2207, 2208)	Novel Protein sim. GBank gi|3293539 (AF072709) - unknown		UNCLASSIFIED	1026
		[Streptomyces lividans]
1495	10179672 (6245, 6246)	Novel Protein sim. GBank gi|3319741|emb|CAA19907| - (AL031035)		UNCLASSIFIED	1003, 1014
		hypothetical protein SC6A9.22c [Streptomyces coelicolor]
1496	28828128 (3695, 3696)	Novel Protein sim. GBank gi|3327262|dbj|BAA31695| - (AB010827) NhaP		UNCLASSIFIED	1006
		[Pseudomonas aeruginosa]
1497	87537695 (4107, 4108)	Novel Protein sim. GBank gi|3328190 (AF074266) - proto-oncogene AF4		UNCLASSIFIED	1002
		[Mus musculus]
1498	78513148 (3401, 3402)	Novel Protein sim. GBank gi|3328774 (AE001308) - Polypeptide		UNCLASSIFIED	1014
		Deformylase [Chlamydia trachomatis]
1499	79619697 (6505, 6506)	Novel Protein sim. GBank gi|3334801|emb|CAA19949| - (AL031107)		UNCLASSIFIED	1003
		putative glucosidase [Streptomyces coelicolor]
1500	80423734 (3315, 3316)	Novel Protein sim. GBank gi|3341622|emb|CAA13155| - (AJ231113) z54f		UNCLASSIFIED	1023
		[Vibrio cholerae]
1501	11083988 (7457, 7458)	Novel Protein sim. GBank gi|3342713 (U22894) - alpha glucosidase		UNCLASSIFIED	1022
		[Streptomyces lividans]
1502	16332226 (155, 156)	Novel Protein sim. GBank gi|3367754|emb|CAA20079| - (AL031155)		UNCLASSIFIED	1001, 1003, 1014
		hypothetical protein SC3A7.16c [Streptomyces coelicolor]
1503	79554871 (7667, 7668)	Novel Protein sim. GBank gi|3367754|emb|CAA20079| - (AL031155)		UNCLASSIFIED	1001
		hypothetical protein SC3A7.16c [Streptomyces coelicolor]
1504	80499745 (8901, 8902)	Novel Protein sim. GBank gi|3367754|emb|CAA20079| - (AL031155)		UNCLASSIFIED	1003, 1004, 1010, 1014,
		hypothetical protein SC3A7.16c [Streptomyces coelicolor]			1035, 1041
1505	13022760 (7205, 7206)	Novel Protein sim. GBank gi|3378298 (AF079317) - putative plasmid		UNCLASSIFIED	1022
		stabilization protein [Sphingomonas aromaticivorans]
1506	66376628 (4491, 4492)	Novel Protein sim. GBank gi|3378429 (AF079317) - unknown		UNCLASSIFIED	1007
		[Sphingomonas aromaticivorans]
1507	20182451 (6715, 6716)	Novel Protein sim. GBank gi|3413827|emb|CAA20295| - (AL031260)		UNCLASSIFIED	1008
		putative dihydrodipicolinate synthase [Streptomyces coelicolor]
1508	10109035 (3729, 3730)	Novel Protein sim. GBank gi|3414871 (AF071034) - CP4-like integrase		UNCLASSIFIED	1015
		[Escherichia coli]
1509	71232053 (7105, 7106)	Novel Protein sim. GBank gi|3414930 (AF076599) - FutA [Dictyostelium		UNCLASSIFIED	1039, 1047, 1051
		discoideum]
1510	11618046 (4361, 4362)	Novel Protein sim. GBank gi|3450883 (AF083334) - fibroin [Antheraea		UNCLASSIFIED	1003
		pernyi]
1511	37021934 (8807, 8808)	Novel Protein sim. GBank gi|3482914 (AC003970) - Similar to nodulins		UNCLASSIFIED	1023
		and lipase [Arabidopsis thaliana]
1512	29267664 (129, 130)	Novel Protein sim. GBank gi|3493|emb|CAA27836| - (X04288) CDC37		UNCLASSIFIED	1020
		gene product [Saccharomyces cerevisiae]
1513	80059321 (3393, 3394)	Novel Protein sim. GBank gi|3581849|emb|CAA20805| - (AL031541)		UNCLASSIFIED	1020, 1022
		putative phenylalanyl-tRNA synthetase beta chain [Streptomyces
		coelicolor]
1514	29694999 (5161, 5162)	Novel Protein sim. GBank gi|3582220 (AE001272) - conserved		UNCLASSIFIED	1022
		hypothetical protein [Lactococcus lactis]
1515	80250065 (1649, 1650)	Novel Protein sim. GBank gi|3594|emb|CAA40571| - (X57316)		UNCLASSIFIED	1004, 1020, 1021
		carboxypeptidase s [Saccharomyces cerevisiae]
1516	78462176 (5405, 5406)	Novel Protein sim. GBank gi|3641340|gb|AAC36351| - (AF090329)		UNCLASSIFIED	1006
		cyclohexanone monooxygenase homolog [Pseudomonas fluorescens]
1517	79633561 (1357, 1358)	Novel Protein sim. GBank gi|3650031 (AC005396) - putative proline-rich		UNCLASSIFIED	1035
		cell wall protein [Arabidopsis thaliana]
1518	27974622 (6149, 6150)	Novel Protein sim. GBank gi|3721912|dbj|BAA33743.1| - (AB017156) gob-		UNCLASSIFIED	1003
		5 [Mus musculus]
1519	27974630 (8553, 8554)	Novel Protein sim. GBank gi|3721912|dbj|BAA33743.1| - (AB017156) gob-		UNCLASSIFIED	1003
		5 [Mus musculus]
1520	79255545 (8065, 8066)	Novel Protein sim. GBank gi|3811377 (AF100956) - tapasin [Mus		UNCLASSIFIED	1002, 1006, 1007, 1015,
		musculus]			1020, 1024, 1026, 1036,
					1041
1521	20396091 (6029, 6030)	Novel Protein sim. GBank gi|3820539 (AF080002) - UDP-N-		UNCLASSIFIED	1003
		acetylmuramyl tripeptide synthetase MurC [Heliobacillus mobilis]
1522	79853458 (7657, 7658)	Novel Protein sim. GBank gi|3834293 (U80846) - No definition line found		UNCLASSIFIED	1002, 1020, 1022
		[Caenorhabditis elegans]
1523	20608530 (967, 968)	Novel Protein sim. GBank gi|3873399|gb|AAC77475.1| - (U17129)		UNCLASSIFIED	1003
		unknown [Rhodococcus erythropolis]
1524	86380142 (2377, 2378)	Novel Protein sim. GBank gi|3873920|emb|CAA97776| - (Z73423) cDNA		UNCLASSIFIED	1050
		EST EMBL: Z14908 comes from this gene; cDNA EST EMBL: M89403
		comes from this gene; cDNA EST EMBL: T00022 comes from this gene
		[Caenorhabditis elegans]
1525	17248601 (7361, 7362)	Novel Protein sim. GBank gi|3875362|emb|CAA84696| - (Z35639) similar		UNCLASSIFIED	1036
		to TNF-alpha induced Protein B12 [Caenorhabditis elegans]
1526	97993778 (3753, 3754)	Novel Protein sim. GBank gi|3877494|emb|CAA88472.1| - (Z48583) ATP		UNCLASSIFIED	1001, 1006, 1023, 1037
		binding protein with similarity to the CDC48/PAS1/SEC18 family; cDNA
		EST EMBL: D65037 comes from this gene; cDNA EST EMBL: D68340
		comes from this gene; cDNA EST EMBL: D65048 comes from this gene;
		cDNA EST EMBL: D6845 . . .
1527	35915568 (3477, 3478)	Novel Protein sim. GBank gi|3878537|emb|CAB05777| - (Z83236) similar		UNCLASSIFIED	1021
		to Sugar (and other) transporters [Caenorhabditis elegans]
1528	56026570 (1303, 1304)	Novel Protein sim. GBank gi|3879594|emb|CAA98283| - (Z73976)		UNCLASSIFIED	1007
		predicted using Genefinder; similar to reverse transcriptase
		[Caenorhabditis elegans]
1529	11816374 (1023, 1024)	Novel Protein sim. GBank gi|3882285|dbj|BAA34502.1| - (AB018325)		UNCLASSIFIED	1022, 1031
		KIAA0782 protein [Homo sapiens]
1530	78984391 (3227, 3228)	Novel Protein sim. GBank gi|3886057 (AF106580) - contains similarity to		UNCLASSIFIED	1014, 1020
		Drosophila diaphanous (SW: P48608) [Caenorhabditis elegans]
1531	78925900 (4925, 4926)	Novel Protein sim. GBank gi|3913032|sp|O30746|ALR2_KLEAE -		UNCLASSIFIED	1036
		ALANINE RACEMASE, CATABOLIC
1532	23290639 (5369, 5370)	Novel Protein sim. GBank gi|3913652|sp|O09046|FIG1_MOUSE - FIG-1		UNCLASSIFIED	1015, 1031
		PROTEIN PRECURSOR
1533	83022629 (7185, 7186)	Novel Protein sim. GBank gi|3914095|sp|O14732|MYO2_HUMAN - MYO-		UNCLASSIFIED	1050
		INOSITOL-1(OR 4)-MONOPHOSPHATASE 2 (IMP 2) (INOSITOL
		MONOPHOSPHATASE 2) (MYO-INOSITOL MONOPHOSPHATASE A2)
1534	39523838 (3859, 3860)	Novel Protein sim. GBank gi|3915144|sp|O33017|TRMD_MYCLE - (TRNA		UNCLASSIFIED	1003
		(GUANINE-N1)-METHYLTRANSFERASE (M1G-
		METHYLTRANSFERASE) (TRNA [GM37] METHYLTRANSFERASE)
1535	78768459 (7865, 7866)	Novel Protein sim. GBank gi|3915170|sp|O69882|TRMD_STRCO - TRNA		UNCLASSIFIED	1006
		(GUANINE-N1)-METHYLTRANSFERASE (M1G-
		METHYLTRANSFERASE) (TRNA [GM37]METHYLTRANSFERASE)
1536	78460574 (7871, 7872)	Novel Protein sim. GBank gi|3915557|sp|O05252|YUFN_BACSU -		UNCLASSIFIED	1024
		HYPOTHETICAL LIPOPROTEIN YUFN PRECURSOR
1537	30179670 (1885, 1886)	Novel Protein sim. GBank gi|3915759|sp|P36044|MNN44_YEAST - MNN4		UNCLASSIFIED	1020
		PROTEIN
1538	8370333 (3909, 3910)	Novel Protein sim. GBank gi|3925211|emb|CAA21539.1| - (AL032626)		UNCLASSIFIED	1008
		cDNA EST EMBL: D70654 comes from this gene; cDNA EST
		EMBL: Z14359 comes from this gene; cDNA EST EMBL: D33409 comes
		from this gene; cDNA EST EMBL: D36239 comes from this gene; cDNA
		EST EMBL: Z14766 comes from this gene; . . .
1539	79201261 (877, 878)	Novel Protein sim. GBank gi|3928723|emb|CAA22219| - (AL034355)		UNCLASSIFIED	1025
		putative ABC transporter [Streptomyces coelicolor]
1540	30576892 (5709, 5710)	Novel Protein sim. GBank gi|3941734 (AF109719) - unknown [Mus		UNCLASSIFIED	1007
		musculus]
1541	95008332 (6819, 6820)	Novel-Protein sim. GBank gi|3947854|emb|CAA22272| - (AL034381)		UNCLASSIFIED	1015
		conserved hypothetical PFAM UPF0031 containing protein
		[Schizosaccharomyces pombe]
1542	79168015 (3223, 3224)	Novel Protein sim. GBank gi|3953459 (AC002328) - F20N2.4 [Arabidopsis		UNCLASSIFIED	1028, 1047
		thaliana]
1543	65458783 (2617, 2618)	Novel Protein sim. GBank gi|3978472 (AF089730) - potassium channel		UNCLASSIFIED	1051
		subunit [Rattus norvegicus]
1544	30575467 (5661, 5662)	Novel Protein sim. GBank gi|400132|sp|Q02974|KHK_RAT -		UNCLASSIFIED	1007
		KETOHEXOKINASE (HEPATIC FRUCTOKINASE)
1545	66727201 (1977, 1978)	Novel Protein sim. GBank gi|400729|sp|P31664|PAND_ECOLI -		UNCLASSIFIED	1046
		ASPARTATE 1-DECARBOXYLASE PRECURSOR (ASPARTATE ALPHA-
		DECARBOXYLASE)
1546	95287719 (8551, 8552)	Novel Protein sim. GBank gi|4007675|emb|CAA22361| - (AL034443)		UNCLASSIFIED	1004, 1008, 1010, 1020,
		putative neuramidase [Streptomyces coelicolor]			1022, 1028
1547	23207548 (2235, 2236)	Novel Protein sim. GBank gi|4007726|emb|CAA22410| - AL034447)		UNCLASSIFIED	1006
		putative methylase [Streptomyces coelicolor]
1548	11103108 (5671, 5672)	Novel Protein sim. GBank gi|4007732|emb|CAA22416| - AL034447)		UNCLASSIFIED	1004
		formamidopyrimidine-DNA glycosylase [Streptomyces coelicolor]
1549	78778050 (7197, 7198)	Novel Protein sim. GBank gi|401087|sp|Q02100|SKO1_YEAST - CRE-		UNCLASSIFIED	1006, 1024
		BINDING BZIP PROTEIN SKO1
1550	66442995 (725, 726)	Novel Protein sim. GBank gi|401444|sp|P30143|YAAJ_ECOLI -		UNCLASSIFIED	1020
		HYPOTHETICAL 51.7 KD PROTEIN IN THRC-TALB INTERGENIC
		REGION (ORF8)
1551	30676397 (8219, 8220)	Novel Protein sim. GBank gi|4033718 (U49397) - unknown [Streptococcus		UNCLASSIFIED	1027
		pyogenes]
1552	20750985 (2927, 2928)	Novel Protein sim. GBank gi|4090263|emb|CAA10518| - (AJ131848)		UNCLASSIFIED	1020
		collagen alpha 1 type X [Rattus norvegicus]
1553	52559933 (1293, 1294)	Novel Protein sim. GBank gi|4091877 (AF061331) - alpha galactosidase		UNCLASSIFIED	1004
		precursor [Saccharopolyspora erythraea]
1554	79179690 (5149, 5150)	Novel Protein sim. GBank gi|4092666 (AF083132) - putative 13.1 kDa E3		UNCLASSIFIED	1025
		protein [Porcine adenovirus 3]
1555	78483307 (3045, 3046)	Novel Protein sim. GBank gi|4099092 (U83179) - unknown [Arabidopsis		UNCLASSIFIED	1024
		thaliana]
1556	80575827 (5763, 5764)	Novel Protein sim. GBank gi|4104168 (AF033339) - UNC-45		UNCLASSIFIED	1004, 1020, 1026, 1055
		[Caenorhabditis briggsae]
1557	82125017 (3069, 3070)	Novel Protein sim. GBank gi|4106620|emb|CAA21375| - (AL031866)		UNCLASSIFIED	1014, 1020
		ORF52, len=440 aa, CAT2, highly similar to 4-hydroxybutyrate CoA
		transferase, eg. CAT2_CLOKL Clostridium kluyveri, (429 aa), 40.0%
		identity in 440 aa overlap, Fasta scores: opt: 954, E(): 0 [Yersinia pestis]
1558	57127447 (8261, 8262)	Novel Protein sim. GBank gi|4154795 (AE001464) - ATP-DEPENDENT		UNCLASSIFIED	1031
		ZINC METALLOPEPTIDASE [Helicobacter pylori J99]
1559	13892897 (6805, 6806)	Novel Protein sim. GBank gi|4155073 (AE001485) - putative [Helicobacter		UNCLASSIFIED	1031
		pylori J99]
1560	14401486 (3901, 3902)	Novel Protein sim. GBank gi|4155568 (AE001527) - putative [Helicobacter		UNCLASSIFIED	1031
		pylori J99]
1561	20729681 (8883, 8884)	Novel Protein sim. GBank gi|4155917 (AE001554) - putative [Helicobacter		UNCLASSIFIED	1004
		pylori J99]
1562	86474057 (3431, 3432)	Novel Protein sim. GBank gi|4160292|emb|CAA77084| - (Y18209) alpha-		UNCLASSIFIED	1051
		N-acetylglucosaminidase [Nicotiana tabacum]
1563	10126713 (8533, 8534)	Novel Protein sim. GBank gi|416162|dbj|BAA03953| - (D16502) ORF2		UNCLASSIFIED	1014
		[Saccharomyces cerevisiae]
1564	66471745 (1391, 1392)	Novel Protein sim. GBank gi|416592|sp|P32323|AGA1_YEAST-A-		UNCLASSIFIED	1007
		AGGLUTININ ATTACHMENT SUBUNIT PRECURSOR
1565	80059698 (3307, 3308)	Novel Protein sim. GBank gi|416605|sp|Q00594|ALKK_PSEOL -		UNCLASSIFIED	1008
		MEDIUM-CHAIN-FATTY-ACID-COA LIGASE (MEDIUM-CHAIN ACYL-
		COA SYNTHETASE)
1566	17710385 (7285, 7286)	Novel Protein sim. GBank gi|41686|emb|CAA35552| - (X17506) hycG		UNCLASSIFIED	1041
		[Escherichia coli]
1567	33205981 (8609, 8610)	Novel Protein sim. GBank gi|417170|sp|Q01264|HYUC_PSESN -		UNCLASSIFIED	1024
		HYDANTOIN UTILIZATION PROTEIN C (ORF4)
1568	29443014 (3083, 3084)	Novel Protein sim. GBank gi|418427|sp|P32634|YEW2_YEAST -		UNCLASSIFIED	1024
		HYPOTHETICAL 195.4 KD PROTEIN IN RPS26B-GLC7 INTERGENIC
		REGION
1569	27261550 (4665, 4666)	Novel Protein sim. GBank gi|418427|sp|P32634|YEW2_YEAST -		UNCLASSIFIED	1024
		HYPOTHETICAL 195.4 KD PROTEIN IN RPS26B-GLC7 INTERGENIC
		REGION
1570	95287711 (8073, 8074)	Novel Protein sim. GBank gi|418480|sp|P32139|YIHR_ECOLI -		UNCLASSIFIED	1002, 1004, 1008, 1010,
		HYPOTHETICAL 34.0 KD PROTEIN IN GLNA-RBN INTERGENIC			1023, 1028, 1036, 1051
		REGION
1571	79444091 (8665, 8666)	Novel Protein sim. GBank gi|4186110|emb|CAA71790| - (Y10831)		UNCLASSIFIED	1022
		putative integrase [Ralstonia eutropha]
1572	79621693 (6319, 6320)	Novel Protein sim. GBank gi|4186115|emb|CAA71794| - (Y10832) trbl		UNCLASSIFIED	1004
		[Raistonia eutropha]
1573	16332215 (3487, 3488)	Novel Protein sim. GBank gi|4200254|emb|CAA22902| - (AL035300)		UNCLASSIFIED	1004
		possible transmembrane protein MLCB1886.05c [Mycobacterium leprae]
1574	11229945 (7095, 7096)	Novel Protein sim. GBank gi|420071|pir||A43336 - microtubule-vesicle		UNCLASSIFIED	1008
		linker CLIP-170 - human
1575	80026071 (901, 902)	Novel Protein sim. GBank gi|4204102 (U10879) - UDP-N-		UNCLASSIFIED	1003, 1004, 1008, 1021,
		acetylmuramoylalanine-D-glutamate ligase; MurD; cell wall synthesis			1028
		protein [Streptomyces coelicolor]
1576	37036258 (3189, 3190)	Novel Protein sim. GBank gi|4210471|dbj|BAA74535.1| - (AB019033)		UNCLASSIFIED	1010
		orfSA [Pseudomonas sp.]
1577	57300817 (5015, 5016)	Novel Protein sim. GBank gi|422531|pir||A46170 - tektin A1 - sea urchin		UNCLASSIFIED	1003, 1004, 1008, 1022,
		(Strongylocentrotus purpuratus)			1031
1578	52563264 (8547, 8548)	Novel Protein sim. GBank gi|42405|emb|CAA28642| - (X04968) put. pifA		UNCLASSIFIED	1025
		gene product (183AA) [Escherichia coli]
1579	10100744 (6189, 6190)	Novel Protein sim. GBank gi|4262236|gb|AAD14529| - (AC006200)		UNCLASSIFIED	1023
		putative ribose 5-phosphate isomerase [Arabidopsis thaliana]
1580	87452727 (795, 796)	Novel Protein sim. GBank gi|4263790|gb|AAD15450| - (AC006068)		UNCLASSIFIED	1023
		putative ch-TOG protein [Arabidopsis thaliana]
1581	11357950 (4245, 4246)	Novel Protein sim. GBank gi|4314381|gb|AAD15591| - (AC006232)		UNCLASSIFIED	1055
		putative proline-rich protein PRP2 precursor [Arabidopsis thaliana]
1582	79909793 (6125, 6126)	Novel Protein sim. GBank gi|4328|emb|CAA47121| - (X66501) RIF1		UNCLASSIFIED	1004, 1010, 1021
		[Saccharomyces cerevisiae]
1583	37003901 (4975, 4976)	Novel Protein sim. GBank gi|4376841|gb|AAD18690| - (AE001639)		UNCLASSIFIED	1026
		Elongation Factor G [Chlamydia pneumoniae]
1584	11813007 (827, 828)	Novel Protein sim. GBank gi|4377309|gb|AAD19119| - (AE001678) YigN		UNCLASSIFIED	1004
		family hypothetical protein [Chlamydia pneumoniae]
1585	6750668 (5261, 5262)	Novel Protein sim. GBank gi|439877 (L27428) - reverse transcriptase		UNCLASSIFIED	1020
		[Homo sapiens]
1586	29145606 (7059, 7060)	Novel Protein sim. GBank gi|4454480|gb|AAD20927| - (AC006234)		UNCLASSIFIED	1015
		putative (1-4)-beta-mannan endohydrolase [Arabidopsis thaliana]
1587	71797646 (2731, 2732)	Novel Protein sim. GBank gi|4455182|emb|CAB36714| - (AL035521)		UNCLASSIFIED	1031
		putative protein [Arabidopsis thaliana]
1588	27831761 (6695, 6696)	Novel Protein sim. GBank gi|4455367|emb|CAB36777.1| - (AL035524)		UNCLASSIFIED	1003, 1055
		putative protein [Arabidopsis thaliana]
1589	20291103 (5615, 5616)	Novel Protein sim. GBank gi|4467246|emb|CAB37571| - (AL035569)		UNCLASSIFIED	1020
		putative phosphodiesterase [Streptomyces coelicolor]
1590	66047851 (7467, 7468)	Novel Protein sim. GBank gi|4494063|emb|CAB39170.1| - (AJ133501)		UNCLASSIFIED	1051
		putative type II myosin heavy chain [Physarum polycephalum]
1591	16839582 (6405, 6406)	Novel Protein sim. GBank gi|4502419|ref|NP_000704.1|pBLVR - biliverdin		UNCLASSIFIED	1041
		reductase B
1592	20297151 (8857, 8858)	Novel Protein sim. GBank gi|4512103|gb|AAD21616.1| - (AF117897)		UNCLASSIFIED	1020
		rab11 binding protein [Bos taurus]
1593	79918511 (8581, 8582)	Novel Protein sim. GBank gi|451544 (U04267) - proline-rich cell wall		UNCLASSIFIED	1001, 1003
		protein [Gossypium barbadense]
1594	35007847 (2703, 2704)	Novel Protein sim. GBank gi|45365|emb|CAA40908| - (X57736) ORF D		UNCLASSIFIED	1000
		[Pseudomonas aeruginosa]
1595	78732473 (5009, 5010)	Novel Protein sim. GBank gi|4538948|emb|CAB39684.1| - (AL049483)		UNCLASSIFIED	1024
		putative protein [Arabidopsis thaliana]
1596	80217239 (7379, 7380)	Novel Protein sim. GBank gi|4539200|emb|CAB39858.1| - (AL049497)		UNCLASSIFIED	1001, 1003, 1008, 1022,
		putative long chain fatty acid coA ligase [Streptomyces coelicolor]			1041
1597	11091330 (525, 526)	Novel Protein sim. GBank gi|4539558|emb|CAB38477.1| - (AL035636)		UNCLASSIFIED	1004
		putative DNA polymerase [Streptomyces coelicolor]
1598	78784477 (4151, 4152)	Novel Protein sim. GBank gi|4539563|emb|CAB38482.1| - (AL035636)		UNCLASSIFIED	1006
		putative transferase [Streptomyces coelicolor]
1599	79254433 (4981, 4982)	Novel Protein sim. GBank gi|4586401|dbj|BAA75199.1| - (D88208)		UNCLASSIFIED	1002, 1006, 1014, 1015,
		hSgt1p [Homo sapiens]			1021, 1035, 1036, 1041,
					1051
1600	20458788 (3149, 3150)	Novel Protein sim. GBank gi|4589285|gb|AAD26430.1|AF13515 -		UNCLASSIFIED	1008
		(AF135154) ferric alcaligin siderophore receptor [Bordetella pertussis]
1601	57293972 (2527, 2528)	Novel Protein sim. GBank gi|460044 (L29389) - Fun12p [Saccharomyces		UNCLASSIFIED	1002, 1004, 1006, 1020,
		cerevisiae]			1031, 1041
1602	8498693 (3293, 3294)	Novel Protein sim. GBank gi|462626|sp|P33749|MSN4_YEAST - ZINC		UNCLASSIFIED	1031
		FINGER PROTEIN MSN4 (MULTICOPY SUPPRESSOR OF SNF1
		PROTEIN 4)
1603	52560914 (3839, 3840)	Novel Protein sim. GBank gi|462730|sp|P33209|NOLT_RHIFR -		UNCLASSIFIED	1010
		NODULATION PROTEIN NOLT PRECURSOR
1604	21414142 (5385, 5386)	Novel Protein sim. GBank gi|462738|sp|P34909|NOT4_YEAST -		UNCLASSIFIED	1020
		GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 4
1605	10302287 (8141, 8142)	Novel Protein sim. GBank gi|465535|sp|P35196|YBL2_YEAST -		UNCLASSIFIED	1001
		HYPOTHETICAL 32.7 KD PROTEIN IN NTH2-COQ1 INTERGENIC
		REGION
1606	94684758 (7521, 7522)	Novel Protein sim. GBank gi|465576|sp|P33345|MOLR_ECOLI -		UNCLASSIFIED	1025
		MOLYBDATE METABOLISM REGULATOR
1607	13076366 (933, 934)	Novel Protein sim. GBank gi|4691395|emb|CAB41562.1| - (AL049727)		UNCLASSIFIED	1022
		putative large secreted protein [Streptomyces coelicolor]
1608	86464894 (4203, 4204)	Novel Protein sim. GBank gi|4753853|emb|CAB42016.1| - (AL049754)		UNCLASSIFIED	1001, 1002, 1003, 1004,
		putative adenylosuccinate synthetase [Streptomyces coelicolor]			1008, 1015, 1020, 1023,
					1025, 1026, 1028, 1031
1609	20403478 (143, 144)	Novel Protein sim. GBank gi|4753873|emb|CAB42036.1| - (AL049754)		UNCLASSIFIED	1003
		putative fructose 1,6-bisphosphate aldolase [Streptomyces coelicolor]
1610	30239854 (1063, 1064)	Novel Protein sim. GBank gi|4758932|ref|NP_004563.1|pPKP2-		UNCLASSIFIED	1024
		plakophilin 2
1611	30638163 (8747, 8748)	Novel Protein sim. GBank gi|4761453|gb|AAD29365.1|AF11938 -		UNCLASSIFIED	1020
		(AF119384) putative CAMP protein [Mus musculus]
1612	80060863 (4877, 4878)	Novel Protein sim. GBank gi|4826478|emb|CAB42896.1| - (Z83844)		UNCLASSIFIED	1015, 1022, 1031
		similar to SH3-binding protein [Homo sapiens]
1613	28814177 (247, 248)	Novel Protein sim. GBank gi|4827044|ref|NP_005112.1|pTRAP - thyroid		UNCLASSIFIED	1041
		hormone receptor-associated protein, 240 kDa subunit
1614	27839834 (6659, 6660)	Novel Protein sim. GBank gi|4867999|gb|AAD31085.1|AF07816 -		UNCLASSIFIED	1020, 1031
		(AF078164) Ku70-binding protein [Homo sapiens]
1615	27975299 (9061, 9062)	Novel Protein sim. GBank gi|4884719|gb|AAD31784.1|AF12620 -		UNCLASSIFIED	1050
		(AF126201) putative alpha-ketoglutarate dependent dioxygenase AtsK
		[Pseudomonas putida]
1616	5394598 (563, 564)	Novel Protein sim. GBank gi|4885647|ref|NP_005472.1|pTRAP - thyroid		UNCLASSIFIED	1055
		hormone receptor-associated protein complex component
1617	78741493 (3553, 3554)	Novel Protein sim. GBank gi|4894336|gb|AAD32424.1| - (AF065404)		UNCLASSIFIED	1020
		pXO1-120 [Bacillus anthracis]
1618	78404939 (6939, 6940)	Novel Protein sim. GBank gi|4928615|gb|AAD33661.1| - (AF134706)		UNCLASSIFIED	1014, 1022
		unknown [Sinorhizobium meliloti]
1619	13516879 (3051, 3052)	Novel Protein sim. GBank gi|4959396|gb|AAD34331.1|AF11248 -		UNCLASSIFIED	1022
		(AF112481) RAD54B protein [Homo sapiens]
1620	57295193 (1507, 1508)	Novel Protein sim. GBank gi|496309 (M33957) - vanadate-resistance		UNCLASSIFIED	1031
		(VAN1) [Saccharomyces cerevisiae]
1621	11309303 (619, 620)	Novel Protein sim. GBank gi|4966270|gb|AAB52261.2| - (U97002) similar		UNCLASSIFIED	1008
		to acyl-CoA dehydrogenases and epoxide hydrolases: Pfam domain
		PF00441 (Acyl-CoA_dh), Score = 57.4, E-value = 1.7e−16, N = 2; contains
		similarity to Pfam domain PF00702 (Hydrolase), Score = 57.4, E-value = 1e−13,
		N = 1 |C . . .
1622	80084353 (4815, 4816)	Novel Protein sim. GBank gi|4980567|gb|AAD35173.1|AE00169 -		UNCLASSIFIED	1001
		(AE001694) iron(lll) ABC transporter, permease protein [Thermotoga
		maritima]
1623	79180453 (4237, 4238)	Novel Protein sim. GBank gi|4980870|gb|AAD35454.1|AE00171 -		UNCLASSIFIED	1028
		(AE001716) conserved hypothetical protein [Thermotoga maritima]
1624	16316665 (5265, 5266)	Novel Protein sim. GBank gi|4981139|gb|AAD35703.1|AE00173 -		UNCLASSIFIED	1051
		(AE001736) conserved hypothetical protein [Thermotoga maritima]
1625	10106090 (7237, 7238)	Novel Protein sim. GBank gi|4981298|gb|AAD35852.1|AE00174 -		UNCLASSIFIED	1010
		(AE001746) conserved hypothetical protein [Thermotoga maritima]
1626	80055391 (7377, 7378)	Novel Protein sim. GBank gi|4981328|gb|AAD35881.1|AE00174 -		UNCLASSIFIED	1001, 1003, 1008, 1019,
		(AE001747) bioY protein [Thermotoga maritima]			1020, 1046
1627	10213168 (395, 396)	Novel Protein sim. GBank gi|4981341|gb|AAD35893.1|AE00174 -		UNCLASSIFIED	1022
		(AE001748) sugar ABC transporter, permease protein [Thermotoga
		maritima]
1628	20450967 (6583, 6584)	Novel Protein sim. GBank gi|4981925|gb|AAD36435.1|AE00179 -		UNCLASSIFIED	1022
		(AE001790) flagellar basal-body rod protein FlgC [Thermotoga maritima]
1629	80017463 (8705, 8706)	Novel Protein sim. GBank gi|4982435|gb|AAD36913.1|AE00182 -		UNCLASSIFIED	1003, 1006, 1020, 1022,
		(AE001822) alpha-mannosidase, putative [Thermotoga maritima]			1025, 1028
1630	79842052 (5905, 5906)	Novel Protein sim. GBank gi|4982454|gb|AAD36931.1|AE00182 -		UNCLASSIFIED	1036, 1041
		(AE001823) ATP-dependent protease LA, putative [Thermotoga maritima]
1631	95287827 (5137, 5138)	Novel Protein sim. GBank gi|4995988|dbj|BAA78221.1| - (AB021506)		UNCLASSIFIED	1002, 1008, 1010, 1021,
		25.6% identical to U1 gene of strain U1102 of HHV-6 [Human herpesvirus			1022, 1026, 1050
		6]
1632	79574205 (3177, 3178)	Novel Protein sim. GBank gi|5019347|emb|CAB44400.1| - (AL078610)		UNCLASSIFIED	1026, 1028
		putative oxidoreductase [Streptomyces coelicolor]
1633	20707230 (3955, 3956)	Novel Protein sim. GBank gi|5051864|emb|CAB38156.2| - (AL035591)		UNCLASSIFIED	1004
		ABC excision nuclease subunit B [Streptomyces coelicolor]
1634	79835127 (1723, 1724)	Novel Protein sim. GBank gi|5091486|gb|AAD39559.1| - (AF031417)		UNCLASSIFIED	1021
		PcaB-like protein [Pseudomonas putida]
1635	37811466 (5687, 5688)	Novel Protein sim. GBank gi|5091610|gb|AAD39599.1|AC00785 -		UNCLASSIFIED	1055
		(AC007858) 10A191.15 [Oryza sativa]
1636	52559430 (883, 884)	Novel Protein sim. GBank gi|5103027|dbj|BAA78765.1| - (AB023419)		UNCLASSIFIED	1035, 1055
		mSox7 [Mus musculus]
1637	79564322 (5967, 5968)	Novel Protein sim. GBank gi|5105612|dbj|BAA80925.1| - (AP000062)		UNCLASSIFIED	1001
		167 aa long hypothetical protein [Aeropyrum pernix]
1638	35893460 (1173, 1174)	Novel Protein sim. GBank gi|5105846|dbj|BAA81158.1| - (AP000063)		UNCLASSIFIED	1050
		479 aa long hypothetical protein [Aeropyrum pernix]
1639	9897023 (1065, 1066)	Novel Protein sim. GBank gi|5107805|gb|AAD25110.2|AF14055 -		UNCLASSIFIED	1036
		(AF140550) ShdA [Salmonella typhimurium]
1640	28841378 (7111, 7112)	Novel Protein sim. GBank gi|5123651|emb|CAB45340.1| - (AL079345)		UNCLASSIFIED	1024
		putative aminotransferase [Streptomyces coelicolor A3(2)]
1641	27981501 (1549, 1550)	Novel Protein sim. GBank gi|5123878|emb|CAB45470.1| - (AL079348)		UNCLASSIFIED	1004
		putative Na(+)/H(+) antiporter [Streptomyces coelicolor]
1642	19726577 (6471, 6472)	Novel Protein sim. GBank gi|5139534|emb|CAB45535.1| - (AJ243174)		UNCLASSIFIED	1023
		hypothetical protein [Pseudomonas fluorescens]
1643	80061959 (1041, 1042)	Novel Protein sim. GBank gi|5139695|dbj|BAA81686.1| - (AB029147)		UNCLASSIFIED	1003, 1004, 1014, 1022,
		expressed in cucumber hypocotyls [Cucumis sativus]			1031, 1035, 1051
1644	17284172 (7559, 7560)	Novel Protein sim. GBank gi|5225378|gb|AAD40879.1|AF11313 -		UNCLASSIFIED	1015
		(AF113136) IL-1 receptor-associated-kinase-M; IRAK-M [Homo sapiens]
1645	57301554 (6257, 6258)	Novel Protein sim. GBank gi|5262605|emb|CAB45743.1| - (AL080150)		UNCLASSIFIED	1003, 1004
		hypothetical protein [Homo sapiens]
1646	11070940 (315, 316)	Novel Protein sim. GBank gi|5292153|gb|AAD41527.1|L48409_-		UNCLASSIFIED	1022
		(L48409) ProQ [Escherichia coli]
1647	27835681 (6793, 6794)	Novel Protein sim. GBank gi|532526 (U06630) - Rts1p [Saccharomyces		UNCLASSIFIED	1004
		cerevisiae]
1648	20293899 (5215, 5216)	Novel Protein sim. GBank gi|5327257|emb|CAA21905.2| - (AL033388)		UNCLASSIFIED	1031
		putative histidine biosynthesis bifunctional aml dotransferase
		[Schizosaccharomyces pombe]
1649	11609242 (3661, 3662)	Novel Protein sim. GBank gi|5354196|gb|AAD42405.1|AF15749 -		UNCLASSIFIED	1003
		(AF157493) hypothetical protein [Zymomonas mobilis]
1650	37800640 (2139, 2140)	Novel Protein sim. GBank gi|5360761|dbj|BAA82150.1| - (AB026288)		UNCLASSIFIED	1010
		pharbin [Rattus norvegicus]
1651	79470632 (5609, 5610)	Novel Protein sim. GBank gi|5361003|gb|AAD42910.1|U12817_-		UNCLASSIFIED	1020
		(U12817) chemotaxis CheV homolog [Vibrio parahaemolyticus]
1652	10841396 (1367, 1368)	Novel Protein sim. GBank gi|538258 (L01880) - elongation factor 1-		UNCLASSIFIED	1006
		gamma [Saccharomyces cerevisiae]
1653	79483387 (5679, 5680)	Novel Protein sim. GBank gi|539177|pir||S37899 - hypothetical protein		UNCLASSIFIED	1020
		YKL074c - yeast (Saccharomyces cerevisiae)
1654	20627828 (7107, 7108)	Novel Protein sim. GBank gi|539663|pir||A42701 - PR264/SC35 protein -		UNCLASSIFIED	1008
		human
1655	17294928 (819, 820)	Novel Protein sim. GBank gi|5410308|gb|AAD43025.1| - (AF100761)		UNCLASSIFIED	1036
		PTD017 [Homo sapiens]
1656	10296742 (6289, 6290)	Novel Protein sim. GBank gi|541121|pir||S40827 - hypothetical protein		UNCLASSIFIED	1002
		o300 - Escherichia coli
1657	80043491 (1595, 1596)	Novel Protein sim. GBank gi|5420387|emb|CAB46679.1| - (AJ243459)		UNCLASSIFIED	1020
		proteophosphoglycan [Leishmania major]
1658	20629628 (4225, 4226)	Novel Protein sim. GBank gi|5441777|emb|CAB46801.1| - (AL096811)		UNCLASSIFIED	1003
		putative transcriptional regulator [Streptomyces coelicolor A3(2)]
1659	78188295 (7953, 7954)	Novel Protein sim. GBank gi|5454006|ref|NP_006471.1|pRGS1 - regulator		UNCLASSIFIED	1026
		of G-protein signalling 14
1660	80248670 (4389, 4390)	Novel Protein sim. GBank gi|5459240|emb|CAB48913.1| - (AL096837)		UNCLASSIFIED	1003, 1004, 1015, 1022,
		hypothetical protein [Streptomyces coelicolor A3(2)]			1025, 1026, 1031
1661	66376423 (3561, 3562)	Novel Protein sim. GBank gi|5459388|emb|CAB50746.1| - (AL096839)		UNCLASSIFIED	1003, 1007, 1028
		putative aminotransferase [Streptomyces coelicolor]
1662	78745654 (8033, 8034)	Novel Protein sim. GBank gi|548391|sp|Q06795|NUSG_BACSU -		UNCLASSIFIED	1006
		TRANSCRIPTION ANTITERMINATlON PROTEIN NUSG
1663	10355349 (8847, 8848)	Novel Protein sim. GBank gi|549456|sp|Q05335|XYS3_PSEPU -		UNCLASSIFIED	1036
		XYLDLEGF OPERON TRANSCRIPTIONAL ACTIVATOR 3
1664	77814605 (341, 342)	Novel Protein sim. GBank gi|549590|sp|P36555|YJDB_SALTY -		UNCLASSIFIED	1035
		HYPOTHETICAL 61.6 KD PROTEIN IN BASS/PMRA-ADIY INTERGENIC
		REGION
1665	29432205 (4149, 4150)	Novel Protein sim. GBank gi|549616|sp|P36139|YK26_YEAST -		UNCLASSIFIED	1006
		HYPOTHETICAL 31.2 KD PROTEIN IN GAP1-NAP1 INTERGENIC
		REGION
1666	78374963 (5263, 5264)	Novel Protein sim. GBank gi|549637|sp|P36159|YK59_YEAST -		UNCLASSIFIED	1036
		HYPOTHETICAL 96.8 KD PROTEIN IN SIS2-MTD1 INTERGENIC
		REGION
1667	20604601 (4321, 4322)	Novel Protein sim. GBank gi|549646|sp|P36168|YK76_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 137.5 KD PROTEIN IN MPL1-PPC1 INTERGENIC
		REGION
1668	56133267 (7615, 7616)	Novel Protein sim. GBank gi|549649|sp|P36028|YK83_YEAST -		UNCLASSIFIED	1020
		PROBABLE ATP-DEPENDENT PERMEASE YKR103W
1669	79240699 (4305, 4306)	Novel Protein sim. GBank gi|549678|sp|P35735|YKF1_YEAST -		UNCLASSIFIED	1002, 1015, 1041
		HYPOTHETICAL 40.5 KD PROTEIN IN NUP120-CSE4 INTERGENIC
		REGION
1670	79490688 (2065, 2066)	Novel Protein sim. GBank gi|549706|sp|P34253|KT12_YEAST - KTI12		UNCLASSIFIED	1020
		PROTEIN
1671	6352896 (4295, 4296)	Novel Protein sim. GBank gi|549771|sp|P36115|YKZ9_YEAST -		UNCLASSIFIED	1055
		HYPOTHETICAL 68.9 KD PROTEIN IN YPT52-DBP7 INTERGENIC
		REGION
1672	66694898 (4887, 4888)	Novel Protein sim. GBank gi|549771|sp|P36115|YKZ9_YEAST -		UNCLASSIFIED	1006, 1008
		HYPOTHETICAL 68.9 KD PROTEIN IN YPT52-DBP7 INTERGENIC
		REGION
1673	87453444 (415, 416)	Novel Protein sim. GBank gi|551288|emb|CAA83914| - (Z33611)		UNCLASSIFIED	1023
		phosphoglycerate mutase [Zea mays]
1674	79856129 (61, 62)	Novel Protein sim. GBank gi|5531324|emb|CAB51045.1| - (AJ009579)		UNCLASSIFIED	1015
		putative alkane 1-monooxygenase [Pseudomonas fluorescens]
1675	86694741 (6989, 6990)	Novel Protein sim. GBank gi|5578850|emb|CAB51252.1| - (AL096872)		UNCLASSIFIED	1016
		hypothetical protein [Streptomyces coelicolor A3(2)]
1676	80062341 (5345, 5346)	Novel Protein sim. GBank gi|5668604|gb|AAD45975.1|AF11533 -		UNCLASSIFIED	1008, 1020
		(AF115334) CmpX [Pseudomonas fluorescens]
1677	20435478 (8607, 8608)	Novel Protein sim. GBank gi|5678923|gb|AAD46809.1|AF15764 -		UNCLASSIFIED	1022
		(AF157643) RecD [Mycobacterium smegmatis]
1678	37812478 (2515, 2516)	Novel Protein sim. GBank gi|5689421|dbj|BAA82994.1| - (AB028965)		UNCLASSIFIED	1055
		KIAA1042 protein [Homo sapiens]
1679	30660264 (8427, 8428)	Novel Protein sim. GBank gi|5689551|dbj|BAA83059.1| - (AB029030)		UNCLASSIFIED	1024
		KIAA1107 protein [Homo sapiens]
1680	37056406 (2095, 2096)	Novel Protein sim. GBank gi|5689883|emb|CAB52046.1| - (AL109732)		UNCLASSIFIED	1047
		hypothetical protein [Streptomyces coelicolor A3(2)]
1681	47656370 (5993, 5994)	Novel Protein sim. GBank gi|5689917|emb|CAB51955.1| - (AL109661)		UNCLASSIFIED	1026
		putative oxidoreductase [Streptomyces coelicolor A3(2)]
1682	78916212 (3339, 3340)	Novel Protein sim. GBank gi|5689948|emb|CAB51985.1| - (AL109663)		UNCLASSIFIED	1036
		putative isoleucyl-tRNA synthetase [Streptomyces coelicolor A3(2)]
1683	27975125 (7145, 7146)	Novel Protein sim. GBank gi|5689958|emb|CAB51995.1| - (AL109663)		UNCLASSIFIED	1004
		putative UDP-N-acetylmuramoylalanine-D-glutamate ligase [Streptomyces
		coelicolor A3(2)]
1684	70336412 (8417, 8418)	Novel Protein sim. GBank gi|5702013|emb|CAB52245.1| - (AJ007904)		UNCLASSIFIED	1007
		splicing factor pTSR1 [Trypanosoma brucel]
1685	21415074 (175, 176)	Novel Protein sim. GBank gi|585159|sp|P37476|FTSH_BACSU - CELL		UNCLASSIFIED	1020
		DIVISION PROTEIN FTSH HOMOLOG
1686	71772271 (749, 750)	Novel Protein sim. GBank gi|586301|sp|P38288|YB12_YEAST -		UNCLASSIFIED	1007
		HYPOTHETICAL 48.0 KD PROTEIN IN CDC28-ARL1 INTERGENIC
		REGION PRECURSOR
1687	9544749 (305, 306)	Novel Protein sim. GBank gi|586348|sp|P38326|YB81_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 34.3 KD PROTEIN IN PCS60-ABD1 INTERGENIC
		REGION
1688	80497095 (5495, 5496)	Novel Protein sim. GBank gi|586407|sp|P38206|RFT1_YEAST -		UNCLASSIFIED	1001, 1002, 1003, 1004,
		NUCLEAR DIVISION RFT1 PROTEIN			1006, 1007, 1008, 1010,
					1015, 1020, 1022, 1023,
					1024, 1025, 1028, 1031,
					1035, 1036, 1041
1689	16464675 (3807, 3808)	Novel Protein sim. GBank gi|586477|sp|P38219|YBN5_YEAST -		UNCLASSIFIED	1041
		HYPOTHETICAL 44.2 KD GTP-BINDING PROTEIN IN SCO2-MRF1
		INTERGENIC REGION
1690	17941407 (5833, 5834)	Novel Protein sim. GBank gi|586732|sp|P37688|YIBN_ECOLI -		UNCLASSIFIED	1036
		HYPOTHETICAL 15.6 KD PROTEIN IN SECB-TDH INTERGENIC
		REGION
1691	80059688 (1715, 1716)	Novel Protein sim. GBank gi|586814|sp|P37484|YYBT_BACSU -		UNCLASSIFIED	1004, 1022, 1031
		HYPOTHETICAL 74.3 KD PROTEIN IN RPLI-COTF INTERGENIC
		REGION
1692	21657669 (4703, 4704)	Novel Protein sim. GBank gi|625182 (L39015) - mitochondrial glutamyl-		UNCLASSIFIED	1003, 1020
		tRNA synthetase [Saccharomyces cerevisiae]
1693	78801027 (8773, 8774)	Novel Protein sim. GBank gi|628660|pir||S37755 - Adenylyl-transferase -		UNCLASSIFIED	1015
		Escherichia coli
1694	37036146 (2163, 2164)	Novel Protein sim. GBank gi|633648|emb|CAA58712| - (X83754) alpha-		UNCLASSIFIED	1010
		COP [Saccharomyces cerevisiae]
1695	25148919 (4157, 4158)	Novel Protein sim. GBank gi|709805|gb|AAC95474.1| - (U21300)		UNCLASSIFIED	1024
		transposase [Corynebacterium striatum]
1696	20403499 (4331, 4332)	Novel Protein sim. GBank gi|709805|gb|AAC95474.1| - (U21300)		UNCLASSIFIED	1003
		transposase [Corynebacterium striatum]
1697	10302823 (7989, 7990)	Novel Protein sim. GBank gi|71562|pir||LRRTA1 - clathrin light chain A1 -		UNCLASSIFIED	1036
		rat (fragment)
1698	70203092 (1767, 1768)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1021
		SUBFAMILY J WARNING ENTRY !!!!
1699	79561090 (2537, 2538)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1035
		SUBFAMILY J WARNING ENTRY !!!!
1700	87120473 (2611, 2612)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1023
		SUBFAMILY J WARNING ENTRY !!!!
1701	86467285 (3137, 3138)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1026
		SUBFAMILY J WARNING ENTRY !!!!
1702	87120109 (5131, 5132)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1016
		SUBFAMILY J WARNING ENTRY !!!!
1703	11770037 (5481, 5482)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1028
		SUBFAMILY J WARNING ENTRY !!!!
1704	77723765 (7443, 7444)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1035
		SUBFAMILY J WARNING ENTRY !!!!
1705	65497572 (8227, 8228)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1014
		SUBFAMILY J WARNING ENTRY !!!!
1706	77560017 (2625, 2626)	Novel Protein sim. GBank gi|728832|sp|P39189|ALU2_HUMAN - !!!! ALU		UNCLASSIFIED	1051
		SUBFAMILY SB WARNING ENTRY !!!!
1707	35056752 (5635, 5636)	Novel Protein sim. GBank gi|728832|sp|P39189|ALU2_HUMAN - !!!! ALU		UNCLASSIFIED	1000
		SUBFAMILY SB WARNING ENTRY !!!!
1708	77809799 (309, 310)	Novel Protein sim. GBank gi|728837|sp|P39194|ALU7_HUMAN - !!!! ALU		UNCLASSIFIED	1048
		SUBFAMILY SQ WARNING ENTRY !!!!
1709	78259870 (859, 860)	Novel Protein sim. GBank gi|728837|sp|P39194|ALU7_HUMAN - !!!! ALU		UNCLASSIFIED	1024
		SUBFAMILY SQ WARNING ENTRY !!!!
1710	78483811 (1927, 1928)	Novel Protein sim. GBank gi|728837|sp|P39194|ALU7_HUMAN - !!!! ALU		UNCLASSIFIED	1024
		SUBFAMILY SQ WARNING ENTRY !!!!
1711	86477767 (4707, 4708)	Novel Protein sim. GBank gi|728850|sp|P08640|AMYH_YEAST -		UNCLASSIFIED	1017
		GLUCOAMYLASE S1/S2 PRECURSOR (GLUCAN 1,4-ALPHA-
		GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE)
1712	79184203 (3903, 3904)	Novel Protein sim. GBank gi|728867|sp|P40602|APG_ARATH - ANTER-		UNCLASSIFIED	1025
		SPECIFIC PROLINE-RICH PROTEIN APG PRECURSOR
1713	79841889 (4103, 4104)	Novel Protein sim. GBank gi|728868|sp|P40603|APG_BRANA - ANTER-		UNCLASSIFIED	1001, 1023, 1041
		SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN CEX)
1714	17903925 (5907, 5908)	Novel Protein sim. GBank gi|729400|sp|P39677|EFG2_YEAST -		UNCLASSIFIED	1006
		ELONGATION FACTOR G, MITOCHONDRIAL 2 PRECURSOR (MEF-G-
		2)
1715	27829695 (5231, 5232)	Novel Protein sim. GBank gi|729633|sp|Q05562|GRPE_STRCO - GRPE		UNCLASSIFIED	1020
		PROTEIN
1716	11668373 (7949, 7950)	Novel Protein sim. GBank gi|731172|sp|P17437|XP2_XENLA - SKIN		UNCLASSIFIED	1022
		SECRETORY PROTEIN XP2 PRECURSOR (APEG PROTEIN)
1717	16844901 (1383, 1384)	Novel Protein sim. GBank gi|731409|sp|P39992|YEC3_YEAST -		UNCLASSIFIED	1021
		HYPOTHETICAL 78.3 KD PROTEIN IN RIP1-URA3 INTERGENIC
		REGION
1718	71793792 (2339, 2340)	Novel Protein sim. GBank gi|731433|sp|P40007|YEJ2_YEAST -		UNCLASSIFIED	1006, 1007
		HYPOTHETICAL 26.9 KD PROTEIN IN MNN1-PM140 INTERGENIC
		REGION
1719	11695753 (2793, 2794)	Novel Protein sim. GBank gi|731445|sp|P40017|YEL4_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 103.3 KD PROTEIN IN PRO3-GCD11 INTERGENIC
		REGION
1720	8489149 (1727, 1728)	Novel Protein sim. GBank gi|731483|sp|P40053|YER0_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 72.4 KD PROTEIN IN PTP3-ILV1 INTERGENIC
		REGION
1721	20482342 (7967, 7968)	Novel Protein sim. GBank gi|731485|sp|P40055|YER2_YEAST -		UNCLASSIFIED	1008
		HYPOTHETICAL 62.3 KD PROTEIN IN PTP3-ILV1 INTERGENIC
		REGION
1722	25234447 (4059, 4060)	Novel Protein sim. GBank gi|731504|sp|P40071|YEU3_YEAST -		UNCLASSIFIED	1041
		HYPOTHETICAL 81.5 KD PROTEIN IN USS1-BEB1 INTERGENIC
		REGION
1723	27850401 (5077, 5078)	Novel Protein sim. GBank gi|731505|sp|P40072|YEU6_YEAST -		UNCLASSIFIED	1020
		HYPOTHETICAL 30.8 KD PROTEIN IN SPR6-RPL17B INTERGENIC
		REGION
1724	9402873 (581, 582)	Novel Protein sim. GBank gi|731586|sp|Q02998|YH19_RHOCA -		UNCLASSIFIED	1002
		HYPOTHETICAL 104.1 KD PROTEIN IN HYPE 3′REGION (ORF19)
1725	79608399 (3767, 3768)	Novel Protein sim. GBank gi|731676|sp|P38796|YHN5_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 44.9 KD PROTEIN IN ERG7-NMD2 INTERGENIC
		REGION
1726	30649562 (4735, 4736)	Novel Protein sim. GBank gi|731678|sp|P38799|YHN8_YEAST -		UNCLASSIFIED	1020
		HYPOTHETICAL 63.3 KD PROTEIN IN NMD2-IRE1 INTERGENIC
		REGION
1727	80503463 (8265, 8266)	Novel Protein sim. GBank gi|731707|sp|P38827|SET1_YEAST - SET1		UNCLASSIFIED	1002, 1006, 1010, 1020,
		PROTEIN			1022, 1025, 1031
1728	20698592 (8489, 8490)	Novel Protein sim. GBank gi|731709|Sp|P38829|YHS2_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 25.7 KD PROTEIN IN MSH1-EPT1 INTERGENIC
		REGION
1729	79621559 (5987, 5988)	Novel Protein sim. GBank gi|731745|sp|P38865|YHX5_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 21.7 KD PROTEIN IN ENO2-STB5 INTERGENIC
		REGION
1730	21437268 (8237, 8238)	Novel Protein sim. GBank gi|731813|sp|P40523|YIF5_YEAST -		UNCLASSIFIED	1020, 1031
		HYPOTHETICAL 70.7 KD PROTEIN IN SNP1-GPP1 INTERGENIC
		REGION
1731	80079877 (989, 990)	Novel Protein sim. GBank gi|731907|sp|P40564|YIS4_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 48.6 KD PROTEIN IN BET1-PAN1 INTERGENIC
		REGION
1732	79601791 (1975, 1976)	Novel Protein sim. GBank gi|731958|sp|P39543|YJT2_YEAST -		UNCLASSIFIED	1001, 1007
		HYPOTHETICAL 26.6 KD PROTEIN IN CDC6-CRY2 INTERGENIC
		REGION PRECURSOR
1733	94677403 (6417, 6418)	Novel Protein sim. GBank gi|731958|sp|P39543|YJT2_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 26.6 KD PROTEIN IN CDC6-CRY2 INTERGENIC
		REGION PRECURSOR
1734	79234237 (7923, 7924)	Novel Protein sim. GBank gi|732010|sp|P39288|YJES_ECOLI -		UNCLASSIFIED	1015
		HYPOTHETICAL 43.1 KD PROTEIN IN PSD-AMIB INTERGENIC
		REGION (F379)
1735	8219373 (4189, 4190)	Novel Protein sim. GBank gi|732085|sp|P39377|IADA_ECOLI -		UNCLASSIFIED	1031
		ISOASPARTYL DIPEPTIDASE
1736	80047417 (6961, 6962)	Novel Protein sim. GBank gi|732099|sp|P39391|YJIT_ECOLI -		UNCLASSIFIED	1008, 1015
		HYPOTHETICAL 58.6 KD PROTEIN IN IADA-MCRD INTERGENIC
		REGION
1737	10167845 (6693, 6694)	Novel Protein sim. GBank gi|732122|sp|P39411|YJJX_ECOLI -		UNCLASSIFIED	1002
		HYPOTHETICAL 18.6 KD PROTEIN IN TRPR-GPMB INTERGENIC
		REGION (F173)
1738	80428548 (5929, 5930)	Novel Protein sim. GBank gi|732198|sp|P40168|YNT5_YEAST -		UNCLASSIFIED	1003, 1004, 1006, 1007,
		HYPOTHETICAL 26.5 KD PROTEIN IN WHI3-CHS1 INTERGENIC			1008, 1010, 1015, 1020,
		REGION			1021, 1022, 1023, 1025,
					1028, 1031, 1036, 1041
1739	95010059 (2715, 2716)	Novel Protein sim. GBank gi|732362|sp|P39616|DHA2_BACSU -		UNCLASSIFIED	1006
		PROBABLE ALDEHYDE DEHYDROGENASE YWDH
1740	56152651 (2215, 2216)	Novel Protein sim. GBank gi|80728|pir||S18942 - hypothetical protein		UNCLASSIFIED	1024, 1026
		(whiB 3′ region) - Streptomyces coelicolor
1741	27372182 (4367, 4368)	Novel Protein sim. GBank gi|808852 (J03477) - unknown protein		UNCLASSIFIED	1007
		[Saccharomyces cerevisiae]
1742	27981046 (579, 580)	Novel Protein sim. GBank gi|81286|pir||S22697 - extensin - Volvox carteri		UNCLASSIFIED	1004
		(fragment)
1743	79182256 (2649, 2650)	Novel Protein sim. GBank gi|81286|pir||S22697 - extensin - Volvox carteri		UNCLASSIFIED	1028, 1036
		(fragment)
1744	17710350 (1997, 1998)	Novel Protein sim. GBank gi|83589|pir||B22671 - TyB protein - yeast		UNCLASSIFIED	1015
		(Saccharomyces cerevisiae) transposon Ty912
1745	80255924 (691, 692)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1008, 1022
		[Human herpesvirus 6]
1746	8491831 (837, 838)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1031
		[Human herpesvirus 6]
1747	20589867 (3597, 3598)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1050
		[Human herpesvirus 6]
1748	78471213 (4047, 4048)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1041
		[Human herpesvirus 6]
1749	11614741 (4519, 4520)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1022
		[Human herpesvirus 6]
1750	79581891 (7327, 7328)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1022
		[Human herpesvirus 6]
1751	78677674 (1953, 1954)	Novel Protein sim. GBank gi|870810 (L43074) - ORF5 [Streptomyces		UNCLASSIFIED	1006
		[glaucescens]
1752	11110490 (1075, 1076)	Novel Protein sim. GBank gi|871531|emb|CAA61199| - (X87947)		UNCLASSIFIED	1020
		glycosyltransferase [Saccharomyces cerevisiae]
1753	11686962 (1949, 1950)	Novel Protein sim. GBank gi|882477 (U28377) - ORF_o211 [Escherichia		UNCLASSIFIED	1028
		coli]
1754	78386617 (7421, 7422)	Novel Protein sim. GBank gi|91205|pir||E29149 - proline-rich protein -		UNCLASSIFIED	1024
		mouse
1755	95412852 (7175, 7176)	Novel Protein sim. GBank gi|924943 (U29539) - ORFB [Mus musculus]		UNCLASSIFIED	1001, 1003, 1008, 1020,
					1022, 1040, 1041
1756	13504589 (8929, 8930)	Novel Protein sim. GBank gi|95100|pir||S21334 - hypothetical protein 4 -		UNCLASSIFIED	1001
		Agrobacterium tumefaciens
1757	57129414 (5259, 5260)	Novel Protein sim. GBank gi|961450|dbJ|BAA09929| - (D63879) KIAA0156		UNCLASSIFIED	1031
		gene product is related to Xenopus nucleolin. [Homo sapiens]
1758	79216186 (5981, 5982)	Novel Protein sim. GBank gi|96198|pir||JC1108 - Na+/H+-exchanging		UNCLASSIFIED	1022
		protein nhaB - Escherichia coli
1759	3375663 (1511, 1512)	Novel Protein sim. GBank gi|2094851|emb|CAA72162| - (Y11304)	Contains protein domain	UNCLASSIFIED	1010
		ferredoxin [Rhodobacter capsulatus]	(PF00111) - 2Fe-2S iron-sulfur
			cluster binding domains
1760	39403334 (481, 482)	Novel Protein sim. GBank gi|730917|sp|P39076|TCPB_YEAST - T-	Contains protein domain	UNCLASSIFIED	1004, 1020, 1022, 1041
		COMPLEX PROTEIN 1, BETA SUBUNIT (TCP-1-BETA) (CCT-BETA)	(PF00118) - TCP-1/cpn60
			chaperonin family
1761	9940240 (3221, 3222)	Novel Protein sim. GBank gi|3581868|emb|CAA20824| - (AL031541)	Contains protein domain	UNCLASSIFIED	1015
		putative glutamine synthetase [Streptomyces coelicolor]	(PF00120) - Glutamine
			synthetase
1762	11688146 (3229, 3230)	Novel Protein sim. GBank gi|2894386|emb|CAA74996| - (Y14683) Bpu101	Contains protein domain	UNCLASSIFIED	1004
		(5m)cytosine-specific DNA modification methyltransferase (C1) [Bacillus	(PF00145) - C-5 cytosine-specific
		pumilus]	DNA methylase
1763	78673297 (6737, 6738)	Novel Protein sim. GBank gi|731628|sp|P38702|YHG2_YEAST -	Contains protein domain	UNCLASSIFIED	1024
		PUTATIVE MITOCHONDRIAL CARRIER YHR002W	(PF00153) - Mitochondrial carrier
			proteins
1764	79247936 (941, 942)	Novel Protein sim. GBank gi|2662573 (AF036693) - Similar to UDP-	Contains protein domain	UNCLASSIFIED	1022
		glucuronosyltransferase [Caenorhabditis elegans]	(PF00201) - UDP-glucoronosyl
			and UDP-glucosyl transferases
1765	80022725 (239, 240)	Novel Protein sim. GBank gi|171523 (J02802) - fumarase	Contains protein domain	UNCLASSIFIED	1003
		[Saccharomyces cerevisiae]	(PF00206) - Lyase
1766	20288092 (1139, 1140)	Novel Protein sim. GBank gi|416644|sp|P11447|ARLY_ECOLI -	Contains protein domain	UNCLASSIFIED	1031
		ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)	(PF00206) - Lyase
1767	79915187(345, 346)	Novel Protein sim. GBank gi|4704562|gb|AAD28162.1|AF10227 -	Contains protein domain	UNCLASSIFIED	1001
		(AF102270) fumarase C [Pseudomonas putida]	(PF00206) - Lyase
1768	16754986 (2841, 2842)	Novel Protein sim. GBank gi|298750|bbs|127942 - photosystem|reaction	Contains protein domain	UNCLASSIFIED	1041
		center protein psaA product [Sorghum bicolor, Qiuji No. 5, Peptide	(PF00223) - Photosystem|psaA
		Chloroplast, 750 aa]	and psaB proteins
1769	42940912 (7619, 7620)		Conlains protein domain	UNCLASSIFIED	1034
			(PF00238) - Ribosomal protein
			L14
1770	79260305 (1443, 1444)	Novel Protein sim. GBank gi|543793|sp|P36953|AFAM_RAT - AFAMIN	Contains protein domain	UNCLASSIFIED	1002
		PRECURSOR (ALPHA-ALBUMIN) (ALPHA-ALB)	(PF00273) - Serum albumin family
1771	79242014 (551, 552)	Novel Protein sim. GBank gi|2326743|emb|CAB10957| - (Z98268)	Contains protein domain	UNCLASSIFIED	1007, 1021
		hypothetical protein Rv1700 [Mycobacterium tuberculosis]	(PF00293) - Bacterial mutT
			protein
1772	66143987 (8011, 8012)	Novel Protein sim. GBank gi|1706734|sp|P19911|F16P_ALCEU -	Contains protein domain	UNCLASSIFIED	1008
		FRUCTOSE-1,6-BISPHOSPHATASE, CHROMOSOMAL (D-FRUCTOSE-	(PF00316) - Fructose-1-6-
		1,6-BISPHOSPHATE 1-PHOSPHOHYDROLASE) (FBPASE)	bisphosphatase
1773	20295089 (5037, 5038)	Novel Protein sim. GBank gi|2495410|sp|P55740|SLYA_ECOLI -	Contains protein domain	UNCLASSIFIED	1031
		TRANSCRIPTIONAL REGULATOR SLYA	(PF00325) - Bacterial regulatory
			proteins, crp family
1774	11773671 (3785, 3786)	Novel Protein sim. GBank gi|1017706 (U17901) - PLAP [Rattus	Contains protein domain	UNCLASSIFIED	1020
		norvegicus]	(PF00400) - WD domain, G-beta
			repeat
1775	78979108 (6567, 6568)		Contains protein domain	UNCLASSIFIED	1041, 1051
			(PF00439) - Bromodomain
1776	20626695 (4261, 4262)	Novel Protein sim. GBank gi|3261533|emb|CAA17469| - (AL021943)	Contains protein domain	UNCLASSIFIED	1003
		fadE8 [Mycobacterium tuberculosis]	(PF00441) - Acyl-CoA
			dehydrogenase
1777	20292744 (7133, 7134)	Novel Protein sim. GBank gi|1174884|sp|P44391|URE1_HAEIN -	Contains protein domain	UNCLASSIFIED	1031
		UREASE ALPHA SUBUNIT (UREA AMIDOHYDROLASE)	(PF00449) - Urease
1778	10195690 (2707, 2708)	Novel Protein sim. GBank gi|1174887|sp|P42873|URE1_STAXY -	Contains protein domain	UNCLASSIFIED	1002
		UREASE ALPHA SUBUNIT (UREA AMIDOHYDROLASE)	(PF00449) - Urease
1779	10867085 (4883, 4884)	Novel Protein sim. GBank gi|2708800 (AF035751) - urease alpha subunit	Contains protein domain	UNCLASSIFIED	1004
		[Synechococcus PCC7002]	PF00449) - Urease
1780	79834132 (1019, 1020)	Novel Protein sim. GBank gi|4204900 (U57100) - unknown [Brucella	Contains protein domain	UNCLASSIFIED	1006
		abortus]	(PF00455) - Bacterial regulatory
			proteins, deoR family
1781	11349599(6173, 6174)	Novel Protein sim. GBank gi|312667|emb|CAA48166| - (X68025)	Contains protein domain	UNCLASSIFIED	1031
		transketolase [Escherichia coli]	(PF00456) - Transketolase
1782	28002779 (2717, 2718)	Novel Protein sim. GBank gi|2564237|emb|CAA71199.1| - (Y10112)	Contains protein domain	UNCLASSIFIED	1002
		omega-6 desaturase [Gossypium hirsutum]	(PF00487) - Fatty acid desaturase
1783	11669560(4897, 4898)		Contains protein domain	UNCLASSIFIED	1022
			(PF00490) - Delta-aminolevulinic
			acid dehydratase
1784	20261727 (6205, 6206)	Novel Protein sim. GBank gi|2950464|emb|CAA17814| - (AL022071)	Contains protein domain	UNCLASSIFIED	1004
		hypothetical protein [Schizosaccharomyces pombe]	(PF00514) - Armadillo/beta-
			catenin-like repeats
1785	20293306 (2141, 2142)	Novel Protein sim. GBank gi|2104303|emb|CAB08632| - (Z95387)	Contains protein domain	UNCLASSIFIED	1031
		hypothetical protein Rv2610c [Mycobacterium tuberculosis]	(PF00534) - Glycosyl transferases
			group 1
1786	79582340 (7679, 7680)	Novel Protein sim. GBank gi|2983961 (AE000748) - succinyl-CoA ligase	Contains protein domain	UNCLASSIFIED	1020
		beta subunit [Aquifex aeolicus]	(PF00549) - CoA-ligases
1787	27929188 (7705, 7706)	Novel Protein sim. GBank gi|3288113|emb|CAB09803| - (Z97067)	Contains protein domain	UNCLASSIFIED	1002, 1004, 1020, 1022,
		elongation factor 1-beta [Beta vulgaris]	(PF00736) - EF-1 guanine		1050
			nucleotide exchange domain
1788	10870719 (1037, 1038)	Novel Protein sim. GBank gi|2507075|sp|P15302|NAGD_ECOLI - NAGD	Contains protein domain	UNCLASSIFIED	1004
		PROTEIN	(PF00807) - Apldaecin
1789	19871965 (8067, 8068)		Contains protein domain	UNCLASSIFIED	1031
			(PF00818) - Ice nucleation protein
			repeat
1790	66442693 (7359, 7360)	Novel Protein sim. GBank gi|1653153|dbj|BAA18069| - (D90911) acriflavin	Contains protein domain	UNCLASSIFIED	1020, 1036
		resistance protein [Synechocystis sp.]	(PF00873) - AcrB/AcrD/AcrF
			family
1791	79209027 (6515, 6516)	Novel Protein sim. GBank gi|1653901|dbj|BAA18811| - (D90917)	Contains protein domain	UNCLASSIFIED	1001, 1008
		acriflavine resistance protein [Synechocystis sp.]	(PF00873) - AcrB/AcrD/AcrF
			family
1792	85800164 (1463, 1464)	Novel Protein sim. GBank gi|2501534|sp|P75802|YLIG_ECOLI -	Contains protein domain	UNCLASSIFIED	1023
		HYPOTHETICAL 49.6 KD PROTEIN IN MOEA-DACC INTERGENIC	(PF00919) - Uncharacterized
		REGION	protein family UPF0004
1793	13519117 (2381, 2382)	Novel Protein sim. GBank gi|2995295|emb|CAA18324| - (AL022268)	Contains protein domain	UNCLASSIFIED	1022
		hypothetical protein SC4H2.08 [Streptomyces coelicolor]	(PF00919) - Uncharacterized
			protein family UPF0004
1794	79652522 (3871, 3872)	Novel Protein sim. GBank gi|3294240|emb|CAA19853| - (AL031031)	Contains protein domain	UNCLASSIFIED	1008, 1024, 1028
		hypothetical protein SC7C7.07 [Streptomyces coelicolor]	(PF00919) - Uncharacterized
			protein family UPF0004
1795	21421629 (7513, 7514)	Novel Protein sim. GBank gi|418514|sp|P32669|TALC_ECOLI -	Contains protein domain	UNCLASSIFIED	1020
		TRANSALDOLASE-LIKE PROTEIN TALC	(PF00923) - Transaldolase
1796	80236478 (7609, 7610)	Novel Protein sim. GBank gi|120626|sp|P25337|G10_YEAST - G10	Contains protein domain	UNCLASSIFIED	1003, 1004, 1006, 1015,
		PROTEIN HOMOLOG	(PF01125) - G10 protein		1020, 1022, 1031, 1036
1797	80581279 (4827, 4828)	Novel Protein sim. GBank gi|400619|sp|P14306|DKA1_YEAST - DKA1	Contains protein domain	UNCLASSIFIED	1002, 1006, 1008,1015,
		PROTEIN (NSP1 PROTEIN) (TFS1 PROTEIN)	(PF01161) -		1020, 1022, 1028, 1051,
			phosphatldylethanolamine-		1055
			binding protein
1798	78522096 (2529, 2530)	Novel Protein sim. GBank gi|1175964|sp|P43544|YFG0_YEAST -	Contains protein domain	UNCLASSIFIED	1000, 1006,1007
		HYPOTHETICAL 25.1 KD PROTEIN IN THI5 5′REGION	(PF01174) - uncharacterized
			protein family UPF0030
1799	14998905 (5889, 5890)	Novel Protein sim. GBank gi|2137494|pir||S66498 - M-sema F protein	Contains protein domain	UNCLASSIFIED	1022
		precusor - mouse	(PF01403) - Sema domain
1800	79633420 (5751, 5752)	Novel Protein sim. GBank gi|1351621|sp|Q09860|YAF6_SCHPO -	Contains protein domain	UNCLASSIFIED	1021, 1036
		PUTATIVE CYSTEINYL-TRNA SYNTHETASE C29E6.06C (CYSTEINE-	(PF01406) - tRNA synthetases
		TRNA LIGASE) (CYSRS)	class I (C)
1801	20435633 (2577, 2578)	Novel Protein sim. GBank gi|146345 (K02844) - phenylalanyl-tRNA	Contains protein domain	UNCLASSIFIED	1022
		synthetase alpha-subunit [Escherichia coli]	(PF01409) - tRNA synthetases
			class II (F)
1802	7432090 (5995, 5996)	Novel Protein sim. GBank gi|1730713|sp|P53971|YNC3_YEAST -	Contains protein domain	UNCLASSIFIED	1055
		HYPOTHETICAL 108.5 KD PROTEIN IN UME3-PUB1 INTERGENIC	(PF01422) - Zinc finger
		REGION
1803	25139015 (6993, 6994)	Novel Protein sim. GBank gi|4982025|gb|AAD36528.1|AE00179 -	Contains protein domain	UNCLASSIFIED	1024
		(AE001797) jag protein, putative [Thermotoga maritima]	(PF01424) - R3H domain
1804	78786559 (6967, 6968)	Novel Protein sim. GBank gi|1351433|sp|P47737|X194_ECOLI - X	Contains protein domain	UNCLASSIFIED	1006
		POLYPEPTIDE (ORF 19) (P19 PROTEIN) (ORF169)	(PF01464) - Transglycosylase
			SLT domain
1805	70287383 (1917, 1918)	Novel Protein sim. GBank gi|136131|sp|P06694|TRA3_ECOLI -	contains protein domain	UNCLASSIFIED	1007
		TRANSPOSASE FOR TRANSPOSON TN21	(PF01526) - Transposase
1806	80234027 (1735, 1736)	Novel Protein sim. GBank gi|227157|prf||1615302A - Zn/Cd resistance	Contains protein domain	UNCLASSIFIED	1020, 1022
		gene [Saccharomyces cerevisiae]	(PF01545) - Cation efflux family
1807	80209420 (233, 234)	Novel Protein sim. GBank gi|2494141|sp|P56064|PRIM_HELPY - DNA	Contains protein domain	UNCLASSIFIED	1031
		PRIMASE	(PF01751) - Toprim domain
1808	36848042 (4401, 4402)	Novel Protein sim. GBank gi|435743|bbs|139151 - (S66567) alpha-atrial	Contains protein domain	UNCLASSIFIED	1050
		natriuretic factor/coat protein, alpha-ANF/coat protein = fusion	(PF01819) - Levivirus coat protein
		polypeptide(coat protein, alpha-atrial natriuretic factor, alpha-ANF)
		[human, bacteriophage fr, expression vector pFAN15, Peptide
		PlasmidSynthetic . . .
1809	21426822 (5517, 5518)	Novel Protein sim. GBank gi|95567|pir||S21562 - hypothetical protein B -	Contains protein domain	UNCLASSIFIED	1020
		Erwinia amylovora	(PF01836) - Transposase
1810	80054040 (4009, 4010)	Novel Protein sim. GBank gi|1001236|dbj|BAA10477| - (D64003)		UNCLASSIFIED	1001, 1003, 1015, 1026,
		hypothetical protein [Synechocystis sp.]			1031, 1050
1811	79163120 (8915, 8916)	Novel Protein sim. GBank gi|1001304|dbj|BAA10791| - (D64006)		UNCLASSIFIED	1028
		hypothetical protein [Synechocystis sp.]
1812	27981021 (4579, 4580)	Novel Protein sim. GBank gi|101245|pir||S15038 - cell division control		UNCLASSIFIED	1004
		protein CDC15 - yeast (Saccharomyces cerevisiae)
1813	12851296 (7091, 7092)	Novel Protein sim. GBank gi|1055177 (U40060) - weakly similar to E.		UNCLASSIFIED	1028
		nidulans bimA gene product (SP: P17885) [Caenorhabditis elegans]
1814	78785447 (4111, 4112)	Novel Protein sim. GBank gi|1074957|pir||164084 - lactoferrin binding		UNCLASSIFIED	1006, 1020
		protein (lbpA) homolog - Haemophilus lnfluenzae (strain Rd KW20)
1815	78676883 (2253, 2254)	Novel Protein sim. GBank gi|1077325|pir||S50966 - probable membrane		UNCLASSIFIED	1007
		protein YLL054c - yeast (Saccharomyces cerevisiae)
1816	30149873 (3987, 3988)	Novel Protein sim. GBank gi|1077333|pir||S51473 - probable membrane		UNCLASSIFIED	1003, 1015, 1020, 1023,
		protein YLR386w - yeast (Saccharomyces cerevisiae)			1025, 1031, 1036
1817	30455430 (2125, 2126)	Novel Protein sim. GBank gi|1077367|pir||S51457 - probable membrane		UNCLASSIFIED	1006
		protein YLR238w - yeast (Saccharomyces cerevisiae)
1818	10205983 (895, 896)	Novel Protein sim. GBank gi|1077411|pir||S51434 - hypothetical protein		UNCLASSIFIED	1004
		YLR189c - yeast (Saccharomyces cerevisiae)
1819	80219715 (2101, 2102)	Novel Protein sim. GBank gi|1077576|pir||S52683 - probable membrane		UNCLASSIFIED	1003, 1004, 1014, 1020,
		protein YDR118w - yeast (Saccharomyces cerevisiae)			1022, 1031
1820	39547823 (7469, 7470)	Novel Protein sim. GBank gi|1084649|pir||S55965 - probable membrane		UNCLASSIFIED	1004, 1036
		protein YLR409c - yeast (Saccharomyces cerevisiae)
1821	79251709 (1645, 1646)	Novel Protein sim. GBank gi|1109849 (U41538) - proline rich		UNCLASSIFIED	1022
		[Caenorhabditis elegans]
1822	80440066 (301, 302)	Novel Protein sim. GBank gi|1110587|bbs|170532 - (S79410) nuclear		UNCLASSIFIED	1008, 1031, 1035
		localization signals (NLS)-binding protein = spot-1 [mice, Balb/c, testes,
		Peptide, 140 aa] [Mus sp.]
1823	20702777 (7387, 7388)	Novel Protein sim. GBank gi|111817|pir||S18426 - hypothetical protein 4 -		UNCLASSIFIED	1004
		rat
1824	78159669 (2761, 2762)	Novel Protein sim. GBank gi|112205|pir||B39066 - proline-rich protein 15 -		UNCLASSIFIED	1050
		rat
1825	10173861 (6687, 6688)	Novel Protein sim. GBank gi|113618|sp|P19537|ALF_CORGL -		UNCLASSIFIED	1003
		FRUCTOSE-BISPHOSPHATE ALDOLASE
1826	78835806 (7143, 7144)	Novel Protein sim. GBank gi|113618|sp|P19537|ALF_CORGL -		UNCLASSIFIED	1006, 1020, 1024
		FRUCTOSE-BISPHOSPHATE ALDOLASE
1827	17927323 (3569, 3570)	Novel Protein sim. GBank gi|1136426|dbj|BAA11500| - (D80005)		UNCLASSIFIED	1035, 1041
		KIAA0183 [Homo sapiens]
1828	30245237 (5493, 5494)	Novel Protein sim. GBank gi|113671|sp|P23964|ALUF_HUMAN - !!!! ALU		UNCLASSIFIED	1041
		CLASS F WARNING ENTRY !!!!
1829	79250012 (6861, 6862)	Novel Protein sim. GBank gi|114699|sp|P18496|ATPY_YEAST - ATP10		UNCLASSIFIED	1023
		PROTEIN
1830	78786528 (1291, 1292)	Novel Protein sim. GBank gi|114908|sp|P28657|BE16_MOUSE - BRAIN		UNCLASSIFIED	1020
		PROTEIN E161
1831	8499644 (2497, 2498)	Novel Protein sim. GBank gi|1167959 (U43409) - cathelin related		UNCLASSIFIED	1003, 1022
		antimicrobial peptide [Mus musculus]
1832	78388041 (2571, 2572)	Novel Protein sim. GBank gi|1169483|sp|P43897|EFTS_HUMAN -		UNCLASSIFIED	1007
		MITOCHONDRIAL ELONGATION FACTOR TS PRECURSOR (EF-TS)
		(EF-TSMT)
1833	7509905 (5725, 5726)	Novel Protein sim. GBank gi|1169782|sp|P45432|FUS6_ARATH - FUSCA		UNCLASSIFIED	1055
		PROTEIN FUS6
1834	80187797 (3427, 3428)	Novel Protein sim. GBank gi|1170950|sp|P43638|MHP1_YEAST - MAP-		UNCLASSIFIED	1055
		HOMOLOGOUS PROTEIN 1
1835	94140105 (3211, 3212)	Novel Protein sim. GBank gi|1171085|sp|P44958|MVIN_HAEIN -		UNCLASSIFIED	1008
		VIRULENCE FACTOR MVIN HOMOLOG
1836	34408496 (1175, 1176)	Novel Protein sim. GBank gi|1172508|sp|P43502|PILI_PSEAE - PILI		UNCLASSIFIED	1027
		PROTEIN
1837	38602558 (3867, 3868)	Novel Protein sim. GBank gi|1172573|sp|P43923|PPCK_HAEIN -		UNCLASSIFIED	1022
		PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)
1838	39507802 (4515, 4516)	Novel Protein sim. GBank gi|1174426|sp|P41833|SPO8_YEAST -		UNCLASSIFIED	1031
		TRANSCRIPTIONAL REGULATOR SPO8
1839	17962587 (3535, 3536)	Novel Protein sim. GBank gi|1174508|sp|P43820|SYFB_HAEIN -		UNCLASSIFIED	1021
		PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN
		(PHENYLALANINE-TRNA LIGASE BETA CHAIN)
		(PHERS)
1840	9875260 (1611, 1612)	Novel Protein sim. GBank gi|1174661|sp|P44594|TGT_HAEIN -		UNCLASSIFIED	1041
		QUEUINE TRNA-RIBOSYLTRANSFERASE (TRNA-GUANINE
		TRANSGLYCOSYLASE) (GUANINE INSERTION ENZYME)
1841	29224577 (5639, 5640)	Novel Protein sim. GBank gi|1174933|sp|P44907|VACB_HAEIN - VACB		UNCLASSIFIED	1027
		PROTEIN HOMOLOG
1842	11293241 (3207, 3208)	Novel Protein sim. GBank gi|1175916|sp|P43583|YFA7_YEAST -		UNCLASSIFIED	1003
		HYPOTHETICAL 207.6 KD PROTEIN IN SMC1-SEC4 INTERGENIC
		REGION
1843	94123912 (2693, 2694)	Novel Protein sim. GBank gi|1175935|sp|P43570|YFC7_YEAST -		UNCLASSIFIED	1001, 1002, 1003, 1004,
		HYPOTHETICAL 57.6 KD PROTEIN IN CAK1-STE2 INTERGENIC			1006, 1007, 1008, 1010,
		REGION			1014, 1015, 1020, 1021,
					1022, 1023, 1025, 1026,
					1028, 1031, 1035, 1036,
					1041, 1046, 1051
1844	28351735 (8819, 8820)	Novel Protein sim. GBank gi|1175942|sp|P43563|MOB2_YEAST - MOB2		UNCLASSIFIED	1004, 1006, 1035
		PROTEIN (MPS1 BINDER 2)
1845	78681486 (5407, 5408)	Novel Protein sim. GBank gi|1176023|sp|P43618|YFL6_YEAST -		UNCLASSIFIED	1006
		HYPOTHETICAL 41.3 KD PROTEIN IN SAP155-YMR31 INTERGENIC
		REGION
1846	80497259 (891, 892)	Novel Protein sim. GBank gi|1176192|sp|P45420|YHCD_ECOLI -		UNCLASSIFIED	1010
		HYPOTHETICAL OUTER MEMBRANE USHER PROTEIN IN GLTF-
		NANT INTERGENIC REGION PRECURSOR
1847	79632494 (8133, 8134)	Novel Protein sim. GBank gi|1176241|sp|P45524|YHET_ECOLI -		UNCLASSIFIED	1035
		HYPOTHETICAL 38.5 KD PROTEIN IN KIFB-PRKB INTERGENIC
		REGION
1848	9858912 (6535, 6536)	Novel Protein sim. GBank gi|1176338|sp|P40355|YJ31_YEAST -		UNCLASSIFIED	1021
		HYPOTHETICAL 108.4 KD PROTEIN IN CBF1-NTA1 INTERGENIC
		REGION
1849	78795674 (1969, 1970)	Novel Protein sim. GBank gi|1176586|sp|P42842|YN53_YEAST -		UNCLASSIFIED	1007
		HYPOTHETICAL 102.3 KD PROTEIN IN DAL82-RFA2 INTERGENIC
		REGION
1850	78767526 (7827, 7828)	Novel Protein sim. GBank gi|1176587|sp|P42843|YN51_YEAST -		UNCLASSIFIED	1006
		HYPOTHETICAL 88.9 KD PROTEIN IN RFA2-STB1 INTERGENIC
		REGION
1851	71841899 (8051, 8052)	Novel Protein sim. GBank gi|1176587|sp|P42843|YN51_YEAST -		UNCLASSIFIED	1020, 1041
		HYPOTHETICAL 88.9 KD PROTEIN IN RFA2-STB1 INTERGENIC
		REGION
1852	80218016 (7011, 7012)	Novel Protein sim. GBank gi|1176588|sp|P42844|YN50_YEAST -		UNCLASSIFIED	1003, 1004, 1006, 1010,
		HYPOTHETICAL 23.5 KD PROTEIN IN RFA2-STB1 INTERGENIC			1020, 1021, 1022, 1031,
		REGION			1035, 1036
1853	66770458 (5433, 5434)	Novel Protein sim. GBank gi|1181176 (L25828) - HrcU [Erwinia		UNCLASSIFIED	1046
		amylovora]
1854	79190469 (8031, 8032)	Novel Protein sim. GBank gi|118376|sp|P21169|DCOR_ECOLI -		UNCLASSIFIED	1022
		ORNITHINE DECARBOXYLASE, CONSTITUTIVE
1855	30655196 (1261, 1262)	Novel Protein sim. GBank gi|1203832 (U46003) - beta-D-glucan		UNCLASSIFIED	1020
		exohydrolase, lsoenzyme Exoll [Hordeum vulgare]
1856	13515110 (157, 158)	Novel Protein sim. GBank gi|1208456|dbj|BAA10624| - (D64004)		UNCLASSIFIED	1022
		hypothetical protein [Synechocystis sp.]
1857	33202438 (2705, 2706)	Novel Protein sim. GBank gi|1213585|dbj|BAA07613| - (D38633)		UNCLASSIFIED	1024
		regulatory protein bphR [Pseudomonas sp.]
1858	79815089 (6269, 6270)	Novel Protein sim. GBank gi|1215732 (U48718) - OphB [Agrobacterium		UNCLASSIFIED	1015
		tumefaciens]
1859	87898900 (1201, 1202)	Novel Protein sim. GBank gi|1230578 (U47057) - orf2 [Vibrio cholerae		UNCLASSIFIED	1013
		O139]
1860	25266043 (145, 146)	Novel Protein sim. GBank gi|123528|sp|P14586|HRP3_PLAFS -		UNCLASSIFIED	1051
		HISTIDINE-RICH PROTEIN
1861	11088357 (4101, 4102)	Novel Protein sim. GBank gi|123530|sp|P04929|HRPX_PLALO -		UNCLASSIFIED	1020
		HISTIDINE-RICH GLYCOPROTEIN PRECURSOR
1862	27354200 (4195, 4196)	Novel Protein sim. GBank gi|123530|sp|P04929|HRPX_PLALO -		UNCLASSIFIED	1024
		HISTIDINE-RICH GLYCOPROTEIN PRECURSOR
1863	79453762 (6577, 6578)	Novel Protein sim. GBank gi|123530|sp|P04929|HRPX_PLALO -		UNCLASSIFIED	1014
		HISTIDINE-RICH GLYCOPROTEIN PRECURSOR
1864	11617285 (7797, 7798)	Novel Protein sim. GBank gi|123530|sp|P04929|HRPX_PLALO -		UNCLASSIFIED	1022
		HISTIDINE-RICH GLYCOPROTEIN PRECURSOR
1865	71095614 (5737, 5738)	Novel Protein sim. GBank gi|1256134|dbj|BAA19501| - (AB002150) YbbE		UNCLASSIFIED	1026, 1050
		[Bacillus subtilis]
1866	78674975 (6473, 6474)	Novel Protein sim. GBank gi|126296|sp|P08548|LIN1_NYCCO - LINE-1		UNCLASSIFIED	1024
		REVERSE TRANSCRIPTASE HOMOLOG
1867	71810492 (6457, 6458)	Novel Protein sim. GBank gi|126690|sp|P22134|MAG_YEAST - DNA-3-		UNCLASSIFIED	1006
		METHYLADENINE GLYCOSIDASE (3-METHYLADENINE DNA
		GLYCOSYLASE) (3MEA DNA GLYCOSYLASE)
1868	95292792 (1365, 1366)	Novel Protein sim. GBank gi|126822|sp|P24279|MCM3_YEAST -		UNCLASSIFIED	1020
		MINICHROMOSOME MAINTENANCE PROTEIN 3
1869	29247836 (1893, 1894)	Novel Protein sim. GBank gi|127360|sp|P08593|MS18_YEAST - MSS18		UNCLASSIFIED	1002, 1020
		PROTEIN
1870	80475239 (3185, 3186)	Novel Protein sim. GBank gi|128399|sp|P14743|NMT_YEAST -		UNCLASSIFIED	1003, 1004, 1008, 1010,
		GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE (PEPTIDE N-			1015, 1020, 1022, 1023,
		MYRISTOYLTRANSFERASE) (MYRISTOYL-COA: PROTEIN N-			1041
		MYRISTOYLTRANSFERASE) (NMT)
1871	6512354 (1493, 1494)	Novel Protein sim. GBank gi|130201|sp|P15083|PIGR_RAT -		UNCLASSIFIED	1020
		POLYMERIC-IMMUNOGLOBULIN RECEPTOR PRECURSOR (PLGR)
		[CONTAINS: SECRETORY COMPONENT]
1872	17696021 (1253, 1254)	Novel Protein sim. GBank gi|1314576 (U51197) - unknown		UNCLASSIFIED	1041
		[Sphingomonas S88].
1873	27842091 (6015, 6016)	Novel Protein sim. GBank gi|1335205|emb|CAA36480| - (X52235) ORFII		UNCLASSIFIED	1004
		[Homo sapiens]
1874	20474314 (5691, 5692)	Novel Protein sim. GBank gi|134253|sp|P13458|SBCC_ECOLI -		UNCLASSIFIED	1022
		EXONUCLEASE SBCC
1875	8487312 (1807, 1808)	Novel Protein sim. GBank gi|1345705|sp|P11433|CC24_YEAST - CELL		UNCLASSIFIED	1020
		DIVISION CONTROL PROTEIN 24 (CALCIUM REGULATORY PROTEIN)
1876	86671073 (87, 88)	Novel Protein sim. GBank gi|134920|sp|P21997|SSGP_VOLCA -		UNCLASSIFIED	1002, 1045
		SULFATED SURFACE GLYCOPROTEIN 185 (SSG 185)
1877	79763364 (7595, 7596)	Novel Protein sim. GBank gi|134920|sp|P21997|SSGP_VOLCA -		UNCLASSIFIED	1021
		SULFATED SURFACE GLYCOPROTEIN 185 (SSG 185)
1878	7643007 (7099, 7100)	Novel Protein sim. GBank gi|1351184|sp|P48527|SYYM_YEAST -		UNCLASSIFIED	1031
		TYROSYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR
		(TYROSINE-TRNA LIGASE) (TYRRS)
1879	79872166 (3571, 3572)	Novel Protein sim. GBank gi|135135|sp|P13030|SYK1_ECOLI - LYSYL-		UNCLASSIFIED	1002
		TRNA SYNTHETASE (LYSINE-TRNA LIGASE) (LYSRS)
1880	11272604 (6829, 6830)	Novel Protein sim. GBank gi|135160|sp|P25345|SYNM_YEAST -		UNCLASSIFIED	1008
		ASPARAGINYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR
		(ASPARAGINE-TRNA LIGASE) (ASNRS)
1881	23308867 (1233, 1234)	Novel Protein sim. GBank gi|1351819|sp|P48234|YG3J_YEAST -		UNCLASSIFIED	1050
		HYPOTHETICAL 81.7 KD PROTEIN IN MOL1-NAT2 INTERGENIC
		REGION
1882	80434029 (2795, 2796)	Novel Protein sim. GBank gi|1351822|sp|P48237|YG3M_YEAST -		UNCLASSIFIED	1004, 1006, 1010, 1022,
		HYPOTHETICAL 101.4 KD PROTEIN IN RPL30B-RSR1 INTERGENIC			1023, 1028, 1031, 1035
		REGION
1883	17297596 (2595, 2596)	Novel Protein sim. GBank gi|1351898|sp|P48840|AGAB_VIBS7 - BETA-		UNCLASSIFIED	1002
		AGARASE B
1884	88097238 (351, 352)	Novel Protein sim. GBank gi|1352400|sp|P45632|EXOC_AZOBR -		UNCLASSIFIED	1016
		PHOSPHOMANNOMUTASE (PMM)
1885	78898882 (1729, 1730)	Novel Protein sim. GBank gi|1352614|sp|P11466|OCTC_RAT -		UNCLASSIFIED	1015
		PEROXISOMAL CARNITINE OCTANOYLTRANSFERASE (COT)
1886	39415921 (8671, 8672)	Novel Protein sim. GBank gi|1352891|sp|P47124|HOC1_YEAST -		UNCLASSIFIED	1022
		PUTATIVE GLYCOSYLTRANSFERASE HOC1 PRECURSOR
1887	30637606 (5811, 5812)	Novel Protein sim. GBank gi|1352893|sp|P47127|YJ51_YEAST -		UNCLASSIFIED	1024
		HYPOTHETICAL 44.4 KD PROTEIN IN MIR1-STE18 INTERGENIC
		REGION
1888	27977408 (601, 602)	Novel Protein sim. GBank gi|1352922|sp|47158|YJ92_YEAST -		UNCLASSIFIED	1020
		HYPOTHETICAL 57.1 KD PROTEIN IN ATP2-RPS5 INTERGENIC
		REGION
1889	11238455 (5177, 5178)	Novel Protein sim. GBank gi|1352922|sp|P47158|YJ92_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 57.1 KD PROTEIN IN ATP2-RPS5 INTERGENIC
		REGION
1890	11613241 (5307, 5308)	Novel Protein sim. GBank gi|1352922|sp|P47158|YJ92_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 57.1 KD PROTEIN IN ATP2-RPS5 INTERGENIC
		REGION
1891	30789199 (689, 690)	Novel Protein sim. GBank gi|1353007|sp|P47019|YJM2_YEAST -		UNCLASSIFIED	1002, 1020
		HYPOTHETICAL 19.3 KD PROTEIN IN GCD14-POS18 INTERGENIC
		REGION
1892	78911349 (391, 392)	Novel Protein sim. GBank gi|1353047|sp|P47083|YJX2_YEAST -		UNCLASSIFIED	1015
		HYPOTHETICAL 67.0 KD PROTEIN IN PRE3-SAG1 INTERGENIC
		REGION
1893	8500628 (2429, 2430)	Novel Protein sim. GBank gi|1353101|sp|P48558|YN45_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 33.6 KD PROTEIN IN MCK1-RP55B INTERGENIC
		REGION
1894	27829902 (5829, 5830)	Novel Protein sim. GBank gi|1353105|sp|P48563|YN37_YEAST -		UNCLASSIFIED	1003, 1004, 1020, 1022,
		HYPOTHETICAL 186.8 KD PROTEIN IN CLA4-MID1 INTERGENIC			1031
		REGION
1895	10101181 (9017, 9018)	Novel Protein sim. GBank gi|1360960|pir||B38965 - hypothetical protein B		UNCLASSIFIED	1035
		(insertion sequence IS1222) - Enterobacter agglomerans
1896	25139813 (8835, 8836)	Novel Protein sim. GBank gi|1361235|pir||S55904 - phosphotransferase		UNCLASSIFIED	1024
		system enzyme II, galactitol specific, protein B - Escherichia coli (strain
		EC3132)
1897	78772612 (1105, 1106)	Novel Protein sim. GBank gi|1363732|pir||S59413 - probable membrane		UNCLASSIFIED	1006
		protein YLR454w - yeast (Saccharomyces cerevisiae)
1898	78673951 (4589, 4590)	Novel Protein sim. GBank gi|1363741|pir||S59392 - probable membrane		UNCLASSIFIED	1024
		protein YLR246w - yeast (Saccharomyces cerevisiae)
1899	25323155 (4999, 5000)	Novel Protein sim. GBank gi|1363750|pir||S59384 - hypothetical protein		UNCLASSIFIED	1015
		YLR419w - yeast (Saccharomyces cerevisiae)
1900	27968519 (7035, 7036)	Novel Protein sim. GBank gi|1363755|pir||S59376 - hypothetical protein		UNCLASSIFIED	1004
		YLR410w - yeast (Saccharomyces cerevisiae)
1901	80233464 (5759, 5760)	Novel Protein sim. GBank gi|136482|sp|P16649|TUP1_YEAST -		UNCLASSIFIED	1006, 1008, 1015, 1022,
		GLUCOSE REPRESSION REGULATORY PROTEIN TUP1			1031
		(FLOCCULATION SUPPRESSOR PROTEIN) (REPRESSOR AER2)
1902	13084252 (8457, 8458)	Novel Protein sim. GBank gi|136586|sp|P09095|TYCA_BACBR -		UNCLASSIFIED	1022
		TYROCIDINE SYNTHETASE I (PHENYLALANINE RACEMASE [ATP-
		HYDROLYZING]
1903	20457637 (4377, 4378)	Novel Protein sim. GBank gi|137026|sp|P22494|UMUC_SALTY - UMUC		UNCLASSIFIED	1008
		PROTEIN
1904	78761131 (3899, 3900)	Novel Protein sim. GBank gi|1375487 (U43076) - cdc37 homolog [Mus		UNCLASSIFIED	1015, 1020, 1041
		musculus]
1905	79970020 (4249, 4250)	Novel Protein sim. GBank gi|138595|sp|P02845|VIT2_CHICK -		UNCLASSIFIED	1031
		VITELLOGENIN II PRECURSOR (MAJOR VITELLOGENIN) [CONTAINS:
		LIPOVITELLIN I (LVI); PHOSVITIN (PV); LIPOVITELLIN II (LVII); YGP40]
1906	78679746 (4021, 4022)	Novel Protein sim. GBank gi|139990|sp|P03740|Y194_LAMBD -		UNCLASSIFIED	1006
		HYPOTHETICAL PROTEIN ORF194
1907	30624144 (2175, 2176)	Novel Protein sim. GBank gi|140464|sp|P25618|YCQ7_YEAST -		UNCLASSIFIED	1007
		HYPOTHETICAL 107.9 KD PROTEIN IN POL4-SRD1 INTERGENIC
		REGION
1908	8372269 (4345, 4346)	Novel Protein sim. GBank gi|140618|sp|P07027|UVRY_ECOLI - UVRY		UNCLASSIFIED	1008
		PROTEIN
1909	86694722 (3143, 3144)	Novel Protein sim. GBank gi|141347|sp|P21320|YR7F_ECOLI -		UNCLASSIFIED	1001, 1002, 1003, 1004,
		HYPOTHETICAL 11.9 KD PROTEIN (ORFF) (RETRON EC67)			1008, 1020, 1021, 1022,
					1031, 1036, 1041, 1051,
					1055
1910	78784624 (8961, 8962)	Novel Protein sim. GBank gi|141470|sp|P19658|EX70_YEAST - 70 KD		UNCLASSIFIED	1041
		EXOCYST COMPLEX PROTEIN
1911	27827987 (131, 132)	Novel Protein sim. GBank gi|1469199|dbj|BAA09487| - (D50928) The		UNCLASSIFIED	1004
		KIAA0138 gene product is novel. [Homo sapiens]
1912	86696050 (9057, 9058)	Novel Protein sim. GBank gi|1480863 (U63332) - super cysteine rich		UNCLASSIFIED	1022, 1041
		protein; SCRP [Homo sapiens]
1913	11072211 (2727, 2728)	Novel Protein sim. GBank gi|152957 (L05004) - 5-enolpyruvylshikimate-3-		UNCLASSIFIED	1031
		phosphate synthase [Staphylococcus aureus]
1914	66396403 (1793, 1794)	Novel Protein sim. GBank gi|1542932|emb|CAB02171| - (Z80108)		UNCLASSIFIED	1006
		hypothetical protein Rv1423 [Mycobacterium tuberculosis]
1915	37799096 (6339, 6340)	Novel Protein sim. GBank gi|1550705|emb|CAB02362| - (Z80225)		UNCLASSIFIED	1010
		hypothetical protein Rv2664 [Mycobacterium tuberculosis]
1916	78511548 (5695, 5696)	Novel Protein sim. GBank gi|1644232|dbj|BAA11082| - (D67066) N-		UNCLASSIFIED	1051
		WASP [Bos taurus]
1917	27826557 (2747, 2748)	Novel Protein sim. GBank gi|1651839|dbj|BAA16766| - (D90900)		UNCLASSIFIED	1031
		hypothetical protein [Synechocystis sp.]
1918	79822071 (5027, 5028)	Novel Protein sim. GBank gi|1651938|dbj|BAA16864| - (D90901) heme		UNCLASSIFIED	1031
		oxygenase [Synechocystis sp.]
1919	32444862 (7065, 7066)	Novel Protein sim. GBank gi|1652989|dbj|BAA17906| - (D90910)		UNCLASSIFIED	1026
		hypothetical protein [Synechocystis sp.]
1920	32733909 (6827, 6828)	Novel Protein sim. GBank gi|1653019|dbj|BAA17936| - (D90910)		UNCLASSIFIED	1001
		cob(I)alamin adenosyltransferase [Synechocystis sp.]
1921	11085697 (5813, 5814)	Novel Protein sim. GBank gi|1653584|dbj|BAA18497| - (D90914)		UNCLASSIFIED	1003
		hypothetical protein [Synechocystis sp.]
1922	12986753 (8733, 8734)	Novel Protein sim. GBank gi|1655665|emb|CAB03731| - (Z81368)		UNCLASSIFIED	1028
		hypothetical protein Rv2395 [Mycobacterium tuberculosis]
1923	77530490 (371, 372)	Novel Protein sim. GBank gi|1655699|emb|CAA69032| - (Y07752)		UNCLASSIFIED	1035
		pherophorin-S [Volvox certeri]
1924	11088690 (985, 986)	Novel Protein sim. GBank gi|1655699|emb|CAA69032| - (Y07752)		UNCLASSIFIED	1020
		pherophorin-S [Volvox carteri]
1925	47660230 (5965, 5966)	Novel Protein sim. GBank gi|1655699|emb|CAA69032| - (Y07752)		UNCLASSIFIED	1026
		pherophorin-S [Volvox carteri]
1926	79240598 (8711, 8712)	Novel Protein sim. GBank gi|1657619 (U72504) - G5p [Arabidopsis		UNCLASSIFIED	1021
		thaliana]
1927	65987546 (93, 94)	Novel Protein sim. GBank gi|168237 (M76546) - hydroxyproline-rich		UNCLASSIFIED	1051
		protein [Hellanthus annuus]
1928	65691817 (2331, 2332)	Novel Protein sim. GBank gi|1703594 (U80439) - coded for by C. elegans		UNCLASSIFIED	1007
		cDNA yk7c8.5; coded for by C. elegans cDNA yk133b3.5; coded for by C.
		elegans cDNA yk65a4.5; coded for by C. elegans cDNA yk7c8.3; coded
		for by C. elegans cDNA CEESQ66F; coded for by C. elegans cDNA
		yk65a4.3; . . .
1929	80486551 (5199, 5200)	Novel Protein sim. GBank gi|1709032|sp|P53035|MIG2_YEAST -		UNCLASSIFIED	1002, 1003, 1008, 1010,
		REGULATORY PROTEIN MIG2			1020, 1021, 1022, 1031
1930	79444559 (685, 686)	Novel Protein sim. GBank gi|1709346|sp|P53617|NRD1_YEAST - NRD1		UNCLASSIFIED	1020
		PROTEIN
1931	78763956 (7585, 7586)	Novel Protein sim. GBank gi|1709399|sp|P52891|NU84_YEAST -		UNCLASSIFIED	1024, 1041
		NUCLEOPORIN NUP84 (NUCLEAR PORE PROTEIN NUP84)
1932	80017553 (5653, 5654)	Novel Protein sim. GBank gi|171124 (M20319) - aminotriazole resistance		UNCLASSIFIED	1004, 1024, 1035
		protein [Saccharomyces cerevisiae]
1933	30420964 (5957, 5958)	Novel Protein sim. GBank gi|172012 (M12087) - thr-tRNA-synthetase		UNCLASSIFIED	1020
		[Saccharomyces cerevisiae]
1934	30658077 (5791, 5792)	Novel Protein sim. GBank gi|172076 (M88605) - contains Cys-4 zinc-		UNCLASSIFIED	1024
		finger, resembles erythroid transcription factor GATA-1; ORF
		[Saccharomyces cerevisiae]
1935	85801318 (1265, 1266)	Novel Protein sim. GBank gi|1722914|sp|Q10388|Y007_MYCTU -		UNCLASSIFIED	1023
		HYPOTHETICAL 61.0 KD PROTEIN CY190.07
1936	65690391 (65, 66)	Novel Protein sim. GBank gi|1722975|sp|Q10636|Y039_MYCTU -		UNCLASSIFIED	1024, 1046
		HYPOTHETICAL 32.2 KD PROTEIN CY130.09 PRECURSOR
1937	80497297 (8589, 8590)	Novel Protein sim. GBank gi|1723025|sp|P53525|Y05L_MYCLE -		UNCLASSIFIED	1010
		HYPOTHETICAL 71.2 KD PROTEIN O659
1938	39563096 (7269, 7270)	Novel Protein sim. GBank gi|1723077|sp|Q11042|Y084_MYCTU -		UNCLASSIFIED	1004
		HYPOTHETICAL 93.4 KD PROTEIN CY50.04C
1939	55631457 (4337, 4338)	Novel Protein sim. GBank gi|1723116|sp|P50876|Y161_HUMAN -		UNCLASSIFIED	1000
		HYPOTHETICAL PROTEIN KIAA0161
1940	57304297 (3335, 3336)	Novel Protein sim. GBank gi|1723643|sp|P53204|YG15_YEAST -		UNCLASSIFIED	1004, 1020, 1024
		HYPOTHETICAL 44.9 KD PROTEIN IN SEC9-MSB2 INTERGENIC
		REGION
1941	80503293 (3905, 3906)	Novel Protein sim. GBank gi|1723643|sp|P53204|YG15_YEAST -		UNCLASSIFIED	1004, 1010, 1041
		HYPOTHETICAL 44.9 KD PROTEIN IN SEC9-MSB2 INTERGENIC
		REGION
1942	80237581 (8897, 8898)	Novel Protein sim. GBank gi|1723697|sp|P53265|YG2W_YEAST -		UNCLASSIFIED	1003, 1004, 1008, 1020,
		HYPOTHETICAL 46.7 KD PROTEIN IN CLB6-SPT6 INTERGENIC			1022, 1023, 1031
		REGION
1943	94992097 (2883, 2884)	Novel Protein sim. GBank gi|1723717|sp|P53285|YG3H_YEAST -		UNCLASSIFIED	1001, 1006, 1015, 1020,
		HYPOTHETICAL 54.5 KD PROTEIN IN CBF2-SKN1 INTERGENIC			1031
		REGION
1944	80238850 (6945, 6946)	Novel Protein sim. GBank gi|1723717|sp|P53285|YG3H_YEAST -		UNCLASSIFIED	1006, 1008, 1020, 1031,
		HYPOTHETICAL 54.5 KD PROTEIN IN CBF2-SKN1 INTERGENIC			1036
		REGION
1945	29353579 (7435, 7436)	Novel Protein sim. GBank gi|1723731|sp|P53298|YG43_YEAST -		UNCLASSIFIED	1006, 1020
		HYPOTHETICAL 47.3 KD PROTEIN IN ATF2-RNR4 INTERGENIC
		REGION
1946	79556773 (3349, 3350)	Novel Protein sim. GBank gi|1723765|sp|P53317|YG5C_YEAST -		UNCLASSIFIED	1035
		HYPOTHETICAL 22.3 KD PROTEIN IN MGA1-GCN4 INTERGENIC
		REGION
1947	30653753 (5373, 5374)	Novel Protein sim. GBank gi|1723766|sp|P53318|COQ6_YEAST -		UNCLASSIFIED	1020
		UBIQUINONE BIOSYNTHESIS MONOOXGENASE COQ6
1948	78796556 (4163, 4164)	Novel Protein sim. GBank gi|1723795|sp|P53197|YGA3_YEAST -		UNCLASSIFIED	1020
		HYPOTHETICAL 62.8 KD TRP-ASP REPEATS CONTAINING PROTEIN
		IN PMC1-TFG2 INTERGENIC REGION
1949	80470228 (4329, 4330)	Novel Protein sim. GBank gi|1723806|sp|P53192|YGC0_YEAST -		UNCLASSIFIED	1002, 1004, 1006, 1007,
		HYPOTHETICAL 27.1 KD PROTEIN IN ALK1-CKB1 INTERGENIC			1008, 1010, 1015, 1020,
		REGION			1021, 1022, 1023, 1024,
					1025, 1028, 1031,1035,
					1036, 1041
1950	87912640 (575, 576)	Novel Protein sim. GBank gi|1723879|sp|P53153|YGI5_YEAST -		UNCLASSIFIED	1007, 1013, 1024
		HYPOTHETICAL 32.1 KD PROTEIN IN MAD1-SCY1 INTERGENIC
		REGION
1951	80491860 (1119, 1120)	Novel Protein sim. GBank gi|1723900|sp|P53140|YGK7_YEAST -		UNCLASSIFIED	1004, 1006, 1007, 1010,
		HYPOTHETICAL 74.6 KD PROTEIN IN TAF60-G4P1 INTERGENIC			1015, 1020, 1025, 1031,
		REGION			1036, 1041
1952	20726486 (2759, 2760)	Novel Protein sim. GBank gi|1723907|sp|P53133|YGL7_YEAST -		UNCLASSIFIED	1004
		HYPOTHETICAL 30.8 KD PROTEIN IN ABC1-CDC20 INTERGENIC
		REGION
1953	57293171 (865, 866)	Novel Protein sim. GBank gi|1723950|sp|P53094|MDS3_YEAST - MDS3		UNCLASSIFIED	1008, 1020, 1022, 1024,
		PROTEIN (MCK1 DOSAGE SUPPRESSOR 3)			1031
1954	30385147 (7437, 7438)	Novel Protein sim. GBank gi|1723969|sp|P53075|YGX8_YEAST -		UNCLASSIFIED	1002, 1008,1020, 1022
		HYPOTHETICAL 66.9 KD PROTEIN IN SAP4-OST5 INTERGENIC
		REGION
1955	57294333 (6675, 6676)	Novel Protein sim. GBank gi|1723978|sp|P53066|YGZ2_YEAST -		UNCLASSIFIED	1003, 1004, 1006, 1015,
		HYPOTHETICAL 20.1 KD PROTEIN IN RTF1-CSE1 INTERGENIC			1020, 1022, 1031
		REGION
1956	56151668 (5747, 5748)	Novel Protein sim. GBank gi|1724028|sp|P43976|YIIM_HAEIN -		UNCLASSIFIED	1002
		HYPOTHETICAL PROTEIN HI0278
1957	27981007 (7395, 7396)	Novel Protein sim. GBank gi|1730680|sp|P53736|YN8O_YEAST -		UNCLASSIFIED	1020
		HYPOTHETICAL 28.6 KD PROTEIN IN DBP6-COQ2 INTERGENIC
		REGION
1958	80478120 (1809, 1810)	Novel Protein sim. GBank gi|1730708|sp|P53977|YNB7_YEAST -		UNCLASSIFIED	1002, 1003, 1004, 1007,
		HYPOTHETICAL 12.5 KD PROTEIN IN HDA1-PUB1 INTERGENIC			1008, 1010, 1015, 1020,
		REGION			1022, 1025, 1028, 1035
1959	16540378 (6765, 6766)	Novel Protein sim. GBank gi|1730818|sp|P54964|YNT2_YEAST - YNT20		UNCLASSIFIED	1036
		PROTEIN
1960	79444729 (8125, 8126)	Novel Protein sim. GBank gi|1730834|sp|P53857|YNX4_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 47.8 KD PROTEIN IN SIN4-URE2 INTERGENIC
		REGION
1961	79233614 (6111, 6112)	Novel Protein sim. GBank gi|1749442|dbj|BAA13779| - (D89117) similar		UNCLASSIFIED	1001
		to Saccharomyces cerevisiae P9642.2 gene product, GENBANK
		Accession Number U40828 [Schizosaccharomyces pombe]
1962	85800340 (7403, 7404)	Novel Protein sim. GBank gi|1750282 (U81808) - putative gamma-		UNCLASSIFIED	1023
		glutamylcysteine synthetase [Thiobacillus ferrooxidans]
1963	80503461 (5595, 5596)	Novel Protein sim. GBank gi|1771524|emb|CAA67934| - (X99622)		UNCLASSIFIED	1008, 1010, 1023
		muconate cycloisomerase [Rhodococcus opacus]
1964	39540480 (3557, 3558)	Novel Protein sim. GBank gi|1781037|emb|CAA64772| - (X95518)		UNCLASSIFIED	1036, 1055
		neuronal tyrosine threonine phosphatase 1 [Mus musculus]
1965	77687658 (833, 834)	Novel Protein sim. GBank gi|1781049|emb|CAB06185| - (Z83863)		UNCLASSIFIED	1022
		hypothetical protein Rv2553c [Mycobacterium tuberculosis]
1966	85801478 (545, 546)	Novel Protein sim. GBank gi|1840087 (U83280) - 39 kDa antigen		UNCLASSIFIED	1035
		[Leishmania donovani]
1967	28382493 (4403, 4404)	Novel Protein sim. GBank gi|1864015|dbj|BAA13521| - (D87968) SHPS-1		UNCLASSIFIED	1041
		[Mus musculus]
1968	51728564 (3139, 3140)	Novel Protein sim. GBank gi|1870011|emb|CAB06862| - (Z92539) prsA		UNCLASSIFIED	1037
		[Mycobacterium tuberculosis]
1969	79862366 (4745, 4746)	Novel Protein sim. GBank gi|1877272|emb|CAB07053| - (Z92770)		UNCLASSIFIED	1010
		hypothetical protein Rv0147 [Mycobacterium tuberculosis]
1970	79617104 (4393, 4394)	Novel Protein sim. GBank gi|1877369|emb|CAB07121| - (Z92772) echA3		UNCLASSIFIED	1031
		[Mycobacterium tuberculosis]
1971	20385917 (4387, 4388)	Novel Protein sim. GBank gi|1881338|dbj|BAA19365| - (AB001488)		UNCLASSIFIED	1003
		PROBABLE INTEGRAL MEMBRANE PROTEIN, SIMILAR TO
		CHLORAMPHENICOL RESISTANCE PROTEIN OF STREPTOMYCES
		VENEZUELAE. [Bacillus subtilis]
1972	65981896 (3219, 3220)	Novel Protein sim. GBank gi|1883006|emb|CAA72271| - (Y11483)		UNCLASSIFIED	1006, 1022, 1041
		jasmonate inducible protein [Brassica napus]
1973	36857907 (3633, 3634)	Novel Protein sim. GBank gi|1890582|emb|CAB01955| - (Z79692) ORF23		UNCLASSIFIED	1014
		[Sinorhizobium meliloti]
1974	91236500 (7181, 7182)	Novel Protein sim. GBank gi|1914685|emb|CAA72742| - (Y12014) RAD23		UNCLASSIFIED	1002
		protein, isoform II [Daucus carota]
1975	35356258 (747, 748)	Novel Protein sim. GBank gi|2065210|emb|CAA73251| - (Y12713) Pro-Pol		UNCLASSIFIED	1014
		dUTPase polyprotein [Mus musculus]
1976	87912784 (3575, 3576)	Novel Protein sim. GBank gi|2065210|emb|CAA73251| - (Y12713) Pro-Pol		UNCLASSIFIED	1016
		dUTPase polyprotein [Mus musculus]
1977	34387207 (3617, 3618)	Novel Protein sim. GBank gi|2065210|emb|CAA73251| - (Y12713) Pro-Pol		UNCLASSIFIED	1024
		dUTPase polyprotein [Mus musculus]
1978	28992228 (5395, 5396)	Novel Protein sim. GBank gi|2072553 (AF001395) - salT gene product		UNCLASSIFIED	1015
		[Oryza sativa]
1979	52481605 (6937, 6938)	Novel Protein sim. GBank gi|2072961 (U93568) - putative p150 [Homo		UNCLASSIFIED	1033
		sapiens]
1980	39568585 (2305, 2306)	Novel Protein sim. GBank gi|2072967 (U93570) - putative p150 [Homo		UNCLASSIFIED	1004
		sapiens]
1981	85520677 (1447, 1448)	Novel Protein sim. GBank gi|2105127 (U64984) - DNA adenine		UNCLASSIFIED	1008, 1046
		methyltransferase [Bacteriophage Mx8]
1982	24111655 (1403, 1404)	Novel Protein sim. GBank gi|21117310|emb|CAB09116.1| - (Z95620)		UNCLASSIFIED	1041
		hypothetical protein [Schizosaccharomyces pombe]
1983	11076468 (5173, 5174)	Novel Protein sim. GBank gi|2119707|pir||A42817 - proline-rich protein		UNCLASSIFIED	1020
		precursor-rat
1984	37799396 (4253, 4254)	Novel Protein sim. GBank gi|2120083|pir||I38588 - transposon LRE2		UNCLASSIFIED	1010
		reverse transcriptase homolog - human
1985	94631768 (8757, 8758)	Novel Protein sim. GBank gi|2121115|pir||I41292 - EcoE type I restriction-		UNCLASSIFIED	1022, 1025, 1028
		modification enzyme R subunit - Escherichia coil
1986	20288144 (9055, 9056)	Novel Protein sim. GBank gi|2126000|pir||I76771 - phosphomannomutase		UNCLASSIFIED	1031
		(EC 5.4.2.8) - Eacherichia coli
1987	27970336 (8291, 8292)	Novel Protein sim. GBank gi|2126373|pir||I40646 - sensor-like protein -		UNCLASSIFIED	1050
		Coxiella bumetil
1988	29448135 (343, 344)	Novel Protein sim. GBank gi|2129717|pir||S71185 - ribonucleoprotein -		UNCLASSIFIED	1024
		Arabidopsis thaliana
1989	80236325 (3171, 3172)	Novel Protein sim. GBank gi|2131374|pir||S567806 - hypothetical protein		UNCLASSIFIED	1004, 1008, 1020, 1041
		YDL242w - yeast (Saccharomyces cerevisiae)
1990	38925223 (5743, 5744)	Novel Protein sim. GBank gi|2131397|pir||S61589 - hypothetical protein		UNCLASSIFIED	1006
		YDR206w - yeaet (Saccharomyces cerevisiae)
1991	80077468 (4867, 4868)	Novel Protein sim. GBank gi|21314101pir||S70223 - hypothetical protein		UNCLASSIFIED	1020
		YDR274c - yeast (Saccharomyces cerevisiae)
1992	80306740 (2589, 2590)	Novel Protein sim. GBank gi|2131497|pir||S69724 - hypothetical protein		UNCLASSIFIED	1020
		YDR445c - yeast (Saccharomyces cerevisiae)
1993	78936150 (7101, 7102)	Novel Protein sim. GBank gi|2131507|pir||S69627 - hypothetical protein		UNCLASSIFIED	1041
		YDR459c - yeast (Saccharomyces cerevisiae)
1994	78784628 (225, 226)	Novel Protein sim. GBank gi|2131736|pir||S64794 - hypothetical protein		UNCLASSIFIED	1007, 1020
		YLL042c - yeast (Saccharomyces cerevisiae)
1995	78997841 (5761, 5762)	Novel Protein sim. GBank gi|2131741|pir||S64829 - hypothetical protein		UNCLASSIFIED	1021
		YLR007w - yeast (Saccharomyces cerevisiae)
1996	25326496 (3897, 3898)	Novel Protein sim. GBank gi|2131751|pir||S64841 - hypothetical protein		UNCLASSIFIED	1024
		YLR019w - yeast (Saccharomyces cerevisiae)
1997	82064955 (485, 486)	Novel Protein sim. GBank gi|2131784|pir||S64954 - hypothetical protein		UNCLASSIFIED	1001, 1002, 1003, 1004,
		YLR117c - yeast (Saccharomyces cerevisiae)			1006, 1007, 1008, 1010,
					1014, 1015, 1020, 1021,
					1022, 1024, 1025, 1026,
					1028, 1031, 1035, 1036,
					1041,1051
1998	79398243 (5053, 5054)	Novel Protein sim. GBank gi|2131821|pir||S69852 - hypothetical protein		UNCLASSIFIED	1004, 1015
		YML031c-a - yeast (Saccharomyces cerevisiae)
1999	78967763 (2783, 2784)	Novel Protein sim. GBank gi|2131998|pir||S66719 - hypothetical protein		UNCLASSIFIED	1006, 1007, 1015, 1020,
		YOL036w - yeast (Saccharomyces cerevisiae)			1021, 1041
2000	78382826 (2367, 2368)	Novel Protein sim. GBank gi|2132006|pir||S66763 - hypothetical protein		UNCLASSIFIED	1015
		YOL070c - yeast (Saccharomyces cerevisiae)
2001	20297705 (3969, 3970)	Novel Protein sim. GBank gi|2132015|pir||S63445 - hypothetical protein		UNCLASSIFIED	1031
		YOL125w - yeast (Saccharomyces cerevisiae)
2002	29689007 (4523, 4524)	Novel Protein sim. GBank gi|2132060|pir||S60992 - hypothetical protein		UNCLASSIFIED	1007, 1051
		YOR112w - yeast (Saccharomyces cerevisiae)
2003	56484781 (8513, 8514)	Novel Protein sim. GBank gi|2132082|pir||S67087 - hypothetical protein		UNCLASSIFIED	1002
		YOR195w - yeast (Saccharomyces cerevisiae)
2004	20760680 (4027, 4028)	Novel Protein sim. GBank gi|2132103|pir||S67155 - hypothetical protein		UNCLASSIFIED	1055
		YOR258w - yeast (Saccharomyces cerevisiae)
2005	94646976 (5423, 5424)	Novel Protein sim. GBank gi|2132149|pir||S63463 - hypothetical protein		UNCLASSIFIED	1022, 1035
		YPL019c - yeast (Saccharomyces cerevisiae)
2006	79835331 (6441, 6442)	Novel Protein sim. GBank gi|2132170|pir||S60928 - hypothetical protein		UNCLASSIFIED	1002, 1021, 1035
		YPL062w - yeast (Saccharomyces cerevisiae)
2007	65462081 (8293, 8294)	Novel Protein sim. GBank gi|2132177|pir||S61115 - hypothetical protein		UNCLASSIFIED	1046
		YPL071c - yeast (Saccharomyces cerevisiae)
2008	80473352 (1985, 1986)	Novel Protein sim. GBank gi|2132192|pir||S69458 - hypothetical protein		UNCLASSIFIED	1001, 1002, 1003, 1004,
		YPL114w - yeast (Saccharomyces cerevisiae)			1006, 1007, 1008, 1010,
					1015, 1020, 1022, 1024,
					1025, 1031, 1041
2009	20416576 (465, 466)	Novel Protein sim. GBank gi|2132244|pir||S61023 - hypothetical protein		UNCLASSIFIED	1022
		YPL242c - yeast (Saccharomyces cerevisiae)
2010	21149717 (3521, 3522)	Novel Protein sim. GBank gi|2132443|pir||S67691 - probable membrane		UNCLASSIFIED	1031
		protein YDL144c - yeast (Saccharomyces cerevisiae)
2011	20545269 (8779, 8780)	Novel Protein sim. GBank gi|2132455|pir||S67742 - probable membrane		UNCLASSIFIED	1020
		protein YDL187c - yeast (Saccharomyces cerevisiae)
2012	79618317 (517, 518)	Novel Protein sim. GBank gi|2132963|pir||S67301 - probable membrane		UNCLASSIFIED	1003
		protein YOR389w - yeast (Saccharomyces cerevisiae)
2013	29360306 (4567, 4568)	Novel Protein sim. GBank gi|2132975|pir||S61116 - probable membrane		UNCLASSIFIED	1020
		protein YPL070w - yeast (Saccharomyces cerevisiae)
2014	28486368 (2051, 2052)	Novel Protein sim. GBank gi|2133005|pir||S65243 - probable membrane		UNCLASSIFIED	1020
		protein YPL224c - yeast (Saccharomyces cerevisiae)
2015	80216525 (1487, 1488)	Novel Protein sim. GBank gi|2133018|pir||S65313 - probable membrane		UNCLASSIFIED	1003, 1006, 1007, 1008,
		protein YPL280w - yeast (Saccharomyces cerevisiae)			1015, 1020, 1022, 1023,
					1024, 1028, 1036, 1041,
2016	25150624 (3619, 3620)	Novel Protein sim. GBank gi|2133036|pir||S59823 - probable membrane		UNCLASSIFIED	1041
		protein YPR164w - yeast (Saccharomyces cerevisiae)
2017	80502266 (5117, 5118)	Novel Protein sim. GBank gi|2133036|pir||S59823 - probable membrane		UNCLASSIFIED	1002, 1004, 1010, 1015,
		protein YPR164w - yeast (Saccharomyces cerevisiae)			1020, 1021, 1022, 1031
2018	78732260 (3497, 3498)	Novel Protein sim. GBank gi|2133039|pir||S59841 - probable membrane		UNCLASSIFIED	1006
		protein YPR184w - yeast Saccharomyces cerevisiae)
2019	87465190 (8829, 8830)	Novel Protein sim. GBank gi|2134431|pir||I50209 - unknown protein -		UNCLASSIFIED	1023
		chicken (fragment)
2020	20621913 (1315, 1316)	Novel Protein sim. GBank gi|2134962|pir||S64705 - cyclophilin-like protein		UNCLASSIFIED	1003
		CyP-60 - human
2021	19895040 (1439, 1440)	Novel Protein sim. GBank gi|2137043|pir||I46880 - unknown protein -		UNCLASSIFIED	1051
		rabbit (fragment)
2022	27974865 (3805, 3806)	Novel Protein sim. GBank gi|2143815|pir||S59131 - Kan-1 protein - rat		UNCLASSIFIED	1003
2023	86475747 (2751, 2752)	Novel Protein sim. GBank gi|2145909|pir||S72946 - lexA protein -		UNCLASSIFIED	1045
		Mycobacterium leprae
2024	95010828 (8577, 6578)	Novel Protein sim. GBank gi|2182087|emb|CAA73844| - (Y13432)		UNCLASSIFIED	1015
		hypothetical protein [Sinorhizobium meliloti]
2025	17903058 (5359, 5360)	Novel Protein sim. GBank gi|218496|dbj|BAA02301| - (D12917) a		UNCLASSIFIED	1002
		component of the pheromone signal transduction pathway
		[Saccharomyces cerevisiae]
2026	65459142 (8357, 8358)	Novel Protein sim. GBank gi|2222753|emb|CAB09977| - (Z97182)		UNCLASSIFIED	1051
		hypothetical protein Rv0605 [Mycobacterium tuberculosis]
2027	65687631 (3193, 3194)	Novel Protein sim. GBank gi|2226005 (U49973) - ORF2: function		UNCLASSIFIED	1043, 1046
		unknown [Homo sapiens]
2028	33187585 (6267, 6268)	Novel Protein sim. GBank gi|2226005 (U49973) - ORF2: function		UNCLASSIFIED	1024
		unknown [Homo sapiens]
2029	78749690 (6677, 6678)	Novel Protein sim. GBank gi|2226256|emb|CAA74543.1| - (Y14084)		UNCLASSIFIED	1007
		hypothetical protein [Bacillus subtilis]
2030	36826780 (383, 384)	Novel Protein sim. GBank gi|2244792|emb|CAB10215.1| - (Z97336)		UNCLASSIFIED	1051
		ankyrin like protein [Arabidopsis thaliana]
2031	17885054 (91, 92)	Novel Protein sim. GBank gi|226591|prf||1603238B - ATP synthase 18 kD-		UNCLASSIFIED	1022
		like protein 4 [Saccharomycetales]
2032	27964418 (2593, 2594)	Novel Protein sim. GBank gi|226591|prf||1603238B - ATP synthase 18 kD-		UNCLASSIFIED	1021, 1031
		like protein 4 [Saccharomycetales]
2033	21414260 (7701, 7702)	Novel Protein sim. GBank gi|2274845|dbj|BAA21534| - (D88461) N-		UNCLASSIFIED	1022
		WASP [Rattus rattus]
2034	78674870 (2951, 2952)	Novel Protein sim. GBank gi|2276394 (U16156) - bifunctional aldolase-		UNCLASSIFIED	1015
		pyrophosphokinase [Streptococcus pneumoniae]
2035	80060440 (5437, 5438)	Novel Protein sim. GBank gi|2293294 (AF008220) - YtjA [Bacillus subtilis]		UNCLASSIFIED	1022
2036	37806838 (1517, 1518)	Novel Protein sim. GBank gi|2293302 (AF008220) - YtqA [Bacillus		UNCLASSIFIED	1055
		subtilis]
2037	57288317 (6035, 6036)	Novel Protein sim. GBank gi|2313504|gb|AAD07468.1| - (AE000555) H.		UNCLASSIFIED	1031, 1050
		pylori predicted coding region HP0386 [Helicobacter pylori 26695]
2038	80209588 (6881, 6882)	Novel Protein sim. GBank gi|2314493|gb|AAD08369.1| - (AE000634)		UNCLASSIFIED	1031
		cation efflux system protein (czcA) [Helicobacter pylori 26695]
2039	15006975 (4621, 4622)	Novel Protein sim. GBank gi|232127|sp|P30191|GAA6_RAT - GAMMA-		UNCLASSIFIED	1025
		AMINOBUTYRIC-ACID RECEPTOR ALPHA-6 SUBUNIT PRECURSOR
		(GABA(A) RECEPTOR)
2040	85549721 (5849, 5850)	Novel Protein sim. GBank gi|2326720|emb|CAA64757| - (X95503) zinc		UNCLASSIFIED	1014, 1022, 1050
		finger protein [Mus musculus]
2041	34408950 (8853, 8854)	Novel Protein sim. GBank gi|2326756|emb|CAB10970| - (Z98268)		UNCLASSIFIED	1024
		hypothetical protein Rv1713 [Mycobacterium tuberculosis]
2042	79876968 (4933, 4934)	Novel Protein sim. GBank gi|2330863|emb|CAB11100| - (Z98533) mma 3′-		UNCLASSIFIED	1015
		end processing protein ma14. [Schizosaccharomyces pombe]
2043	79853004 (2295, 2296)	Novel Protein sim. GBank gi|2340079|gb|AAB67303.1| - (U59485) AttH		UNCLASSIFIED	1036, 1041
		[Agrobacterium tumefaciens]
2044	78392934 (171, 172)	Novel Protein sim. GBank gi|2384732 (AF015911) - NAC-1 protein [Rattus		UNCLASSIFIED	1006
		norvegicus]
2045	8358495 (6685, 6686)	Novel Protein sim. GBank gi|2388584 (AC000098) - EST gb|ATTS1136		UNCLASSIFIED	1003
		comes from this gene. [Arabidopsis thaliana]
2046	66002976 (1011, 1012)	Novel Protein sim. GBank gi|2388966|emb|CAB11699| - (Z98979)		UNCLASSIFIED	1008
		putative phosphatidylserine decarboxylase proenzyme
		[Schizosaccharomyces pombe]
2047	78723438 (8475, 8476)	Novel Protein sim. GBank gi|2494842|sp|Q12001|ALG6_YEAST -		UNCLASSIFIED	1002, 1006, 1015, 1020,
		GLUCOSYLTRANSFERASE ALG6			1024, 1036
2048	66376633 (6009, 6010)	Novel Protein sim. GBank gi|2495497|sp|P77489|YAGR_ECOLI -		UNCLASSIFIED	1007
		HYPOTHETICAL 78.1 KD PROTEIN IN INTF-EAEH INTERGENIC
		REGION
2049	10193191 (4363, 4364)	Novel Protein sim. GBank gi|2495538|sp|P77717|YBAY_ECOLI -		UNCLASSIFIED	1001
		HYPOTHETICAL 19.4 KD LIPOPROTEIN IN TESB-HHA INTERGENIC
		REGION PRECURSOR
2050	78958713 (8037, 8038)	Novel Protein sim. GBank gi|2496666|sp|P55508|Y4JH_RHISN -		UNCLASSIFIED	1006
		HYPOTHETICAL 23.0 KD PROTEIN Y4JH
2051	29355668 (4893, 4894)	Novel Protein sim. GBank gi|2497080|sp|Q03640|YMH2_YEAST -		UNCLASSIFIED	1007
		HYPOTHETICAL 171.1 KD PROTEIN IN YL16A-DAK1 INTERGENIC
		REGION
2052	80218984 (1981, 1982)	Novel Protein sim. GBank gi|2497127|sp|Q05131|YMS4_YEAST -		UNCLASSIFIED	1003, 1004, 1010, 1020,
		HYPOTHETICAL 48.4 KD PROTEIN IN ARP9-IMP2 INTERGENIC			1021, 1022, 1027, 1031,
		REGION			1035
2053	57292207 (4687, 4688)	Novel Protein sim. GBank gi|2497127|sp|Q05131|YMS4_YEAST -		UNCLASSIFIED	1004, 1020
		HYPOTHETICAL 48.4 KD PROTEIN IN ARP9-IMP2 INTERGENIC
		REGION
2054	27837596 (6573, 6574)	Novel Protein sim. GBank gi|2497145|sp|Q04304|YMY0_YEAST -		UNCLASSIFIED	1008, 1020, 1022, 1041
		HYPOTHETICAL 24.9 KD PROTEIN IN RCA1-NPL6 INTERGENIC
		REGION
2055	20441416 (9067, 9068)	Novel Protein sim. GBank gi|2497150|sp|Q04436|YMZ3_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 13.3 KD PROTEIN IN SNZ1-YPK2 INTERGENIC
		REGION
2056	78751846 (7047, 7048)	Novel Protein sim. GBank gi|2497168|sp|Q03823|YM35_YEAST -		UNCLASSIFIED	1024
		HYPOTHETICAL 95.1 KD PROTEIN IN IMP1-HLJ1 INTERGENIC
		REGION
2057	80467122 (731, 732)	Novel Protein sim. GBank gi|2497174|sp|Q03218|YM43_YEAST -		UNCLASSIFIED	1001, 1002, 1004, 1006,
		HYPOTHETICAL 58.2 KD PROTEIN IN SIP18-SPT21 INTERGENIC			1007, 1008, 1010, 1015,
		REGION			1020, 1021, 1024, 1031,
					1038, 1041
2058	80218524 (6461, 6462)	Novel Protein sim. GBank gi|2497179|sp|Q12751|YM48_YEAST -		UNCLASSIFIED	1004, 1014, 1015, 1020
		HYPOTHETICAL 113.2 KD PROTEIN IN SSO2-HSC82 INTERGENIC
		REGION
2059	80223378 (4317, 4318)	Novel Protein sim. GBank gi|2497182|sp|Q04329|YM53_YEAST -		UNCLASSIFIED	1020, 1022, 1036
		HYPOTHETICAL 14.3 KD PROTEIN IN RPL39-VTI1 INTERGENIC
		REGION
2060	95317140 (8593, 8594)	Novel Protein sim. GBank gi|2497197|sp|Q05027|YM75_YEAST -		UNCLASSIFIED	1001, 1002, 1003, 1004,
		HYPOTHETICAL 17.3 KD PROTEIN IN RNA1-RNT1 INTERGENIC			1006, 1008, 1010, 1014,
		REGION			1015, 1020, 1022, 1024,
					1026, 1028, 1031, 1035,
					1042
2061	10328702 (1709, 1710)	Novel Protein sim. GBank gi|2497226|sp|Q04869|YM94_YEAST -		UNCLASSIFIED	1023
		HYPOTHETICAL 38.2 KD PROTEIN IN PRE5-FET4 INTERGENIC
		REGION
2062	80258357 (3463, 3464)	Novel Protein sim. GBank gi|2497948|sp|Q12428|YP02_YEAST -		UNCLASSIFIED	1007, 1020
		HYPOTHETICAL 57.7 KD PROTEIN IN CIT3-HAL1 INTERGENIC
		REGION
2063	79816346 (5651, 5652)	Novel Protein sim. GBank gi|2498298|sp|Q12387|DEC1_YEAST - DEC1		UNCLASSIFIED	1001, 1004, 1020, 1022,
		PROTEIN (MDM20 PROTEIN)			1024
2064	36849914 (719, 720)	Novel Protein sim. GBank gi|2498325|sp|Q62894|ECM1_RAT -		UNCLASSIFIED	1050
		EXTRACELLULAR MATRIX PROTEIN 1 (SECRETORY COMPONENT
		P85)
2065	80217443 (401, 402)	Novel Protein sim. GBank gi|2498859|sp|Q02805|ROD1_YEAST - ROD1		UNCLASSIFIED	1002, 1003, 1004, 1008,
		PROTEIN			1015, 1022, 1055
2066	47656827 (2009, 2010)	Novel Protein sim. GBank gi|2500719|sp|Q50612|SEA2_MYCTU -		UNCLASSIFIED	1026
		PREPROTEIN TRANSLOCASE SECA 2 SUBUNIT
2067	80503916 (1555, 1556)	Novel Protein sim. GBank gi|2500728|sp|Q59912|SECY_STRGB -		UNCLASSIFIED	1010, 1021, 1022
		PREPROTEIN TRANSLOCASE SECY SUBUNIT
2068	79603634 (5809, 5810)	Novel Protein sim. GBank gi|2506924|sp|P49754|VP41_HUMAN -		UNCLASSIFIED	1031
		VACUOLAR ASSEMBLY PROTEIN VPS41 HOMOLOG (S53)
2069	36831196 (3665, 3666)	Novel Protein sim. GBank gi|2507089|sp|P31554|OSTA_ECOLI -		UNCLASSIFIED	1051
		ORGANIC SOLVENT TOLERANCE PROTEIN PRECURSOR
2070	12904352 (3385, 3386)	Novel Protein sim. GBank gi|2507430|sp|P07395|SYFB_ECOLI -		UNCLASSIFIED	1003
		PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN
		(PHENYLALANINE-
		TRNA LIGASE BETA CHAIN) (PHERS)
2071	8490739 (3091, 3092)	Novel Protein sim. GBank gi|254450|bbs|112161 - (S44213)		UNCLASSIFIED	1022
		YKL525 = TUP1 homolog [Saccharomyces cerevisiae, Peptide, 849 aa]
		(Saccharomyces cerevisiae]
2072	87453418 (5941, 5942)	Novel Protein sim. GBank gi|2618699 (AC002510) - unknown protein		UNCLASSIFIED	1023
		[Arabidopsis thaliana]
2073	33205947 (1311, 1312)	Novel Protein sim. GBank gi|2624970 (AF020312) - proline-rich protein 9-1		UNCLASSIFIED	1024
		[Mus musculus]
2074	79571610 (333, 334)	Novel Protein sim. GBank gi|2626836|dbj|BAA23413| - (D86947)		UNCLASSIFIED	1015
		chemotactic transducer [Pseudomonas aeruginosa]
2075	20292038 (4973, 4974)	Novel Protein sim. GBank gi|2634032|emb|CAB13533| - (Z99112) nusA		UNCLASSIFIED	1031
		[Bacillus subtilis]
2076	39460161 (2425, 2426)	Novel Protein sim. GBank gi|2635815|emb|CAB15308| - (Z99120) similar		UNCLASSIFIED	1003
		to iron-binding protein [Bacillus subtilis]
2077	57292229 (4333, 4334)	Novel Protein sim. GBank gi|2644|emb|CAA41257| - (X58363) Pet127		UNCLASSIFIED	1002, 1020, 1036
		[Saccharomyces cerevisiae]
2078	71753462 (4017, 4018)	Novel Protein sim. GBank gi|2660676 (AC002342) - Dreg-2 like protein		UNCLASSIFIED	1021
		[Arabidopsis thaliana]
2079	28976545 (6885, 6886)	Novel Protein sim. GBank gi|2662054|dbj|BAA23678| - (AB004651)		UNCLASSIFIED	1024
		isocitrate lyase [Hyphomicroblum methylovorum]
2080	79574400 (3877, 3878)	Novel Protein sim. GBank gi|2688682 (AE001174) - conserved		UNCLASSIFIED	1028
		hypothetical protein [Borrelia burgdorferi]
2081	71744800 (3203, 3204)	Novel Protein sim. GBank gi|2707972 (U76754) - unknown [Mus		UNCLASSIFIED	1002, 1036
		musculus]
2082	78926051 (3705, 3706)	Novel Protein sim. GBank gi|2791412|emb|CAA16006| - (AL021184)		UNCLASSIFIED	1006
		hypothetical protein Rv1478 [Mycobacterium tuberculosis]
2083	38340009 (5697, 5698)	Novel Protein sim. GBank gi|2791586|emb|CAA16074.1| - (AL021287)		UNCLASSIFIED	1006, 1010
		hypothetical protein Rv2989 [Mycobacterium tuberculosis]
2084	80079283 (4507, 4508)	Novel Protein sim, GBank gi|2791610|emb|CAA16098.1| - (AL021287)		UNCLASSIFIED	1024, 1031
		hypothetical protein Rv3013 [Mycobacterium tuberculosis]
2085	78769005 (7241, 7242)	Novel Protein sim. GBank gi|2815315|emb|CAA16438| - (AL021529)		UNCLASSIFIED	1015
		hypothetical protein SC10A5.06 [Streptomyces coelicolor]
2086	86672815 (5391, 5392)	Novel Protein sim. GBank gi|2827605|emb|CAA16660| - (AL021646)		UNCLASSIFIED	1017
		hypothetical protein Rv3195 [Mycobacterium tuberculosis]
2087	87464388 (8079, 8080)	Novel Protein sim. GBank gi|282994|pir||S27762 - Sip1 protein - barley		UNCLASSIFIED	1023
2088	66314545 (6995, 6996)	Novel Protein sim. GBank gi|2832228 (AF012126) - zinc finger protein		UNCLASSIFIED	1014, 1033
		[Homo sapiens]
2089	28465093 (117, 118)	Novel Protein sim. GBank gi|2833481|sp|Q57122|Y322_HAEIN -		UNCLASSIFIED	1014
		HYPOTHETICAL PROTEIN HI0322
2090	66770629 (4873, 4874)	Novel Protein sim. GBank gi|2853221 (U72953) - merozoite surface		UNCLASSIFIED	1046
		porotein 2 [Plasmodium falciparum]
2091	77706782 (6089, 6090)	Novel Protein sim. GBank gi|2853301 (AF007194) - mucin [Homo		UNCLASSIFIED	1041
		sapiens]
2092	86473162 (6591, 6592)	Novel Protein sim. GBank gi|2894254|emb|CAA17116.1| - (AL021841)		UNCLASSIFIED	1026
		PE_PGRS [Mycobacterium tuberculosis]
2093	34082841 (6763, 6764)	Novel Protein sim. GBank gi|2895563 (AF041083) - RoBo-1 [Rattus		UNCLASSIFIED	1000
		norvegicus]
2094	19848631 (4499, 4500)	Novel Protein sim. GBank gi|2896702|emb|CAA17181.1| - (AL021897)		UNCLASSIFIED	1031
		hypothetical protein Rv1065 [Mycobacterium tuberculosis]
2095	78387912 (2437, 2438)	Novel Protein sim. GBank gi|2911858 (AF047659) - No definition line		UNCLASSIFIED	1024, 1043
		found [Caenorhabditis elegans]
2096	20562660 (4177, 4178)	Novel Protein sim. GBank gi|2960089|emb|CAA17987.1| - (AL022121)		UNCLASSIFIED	1055
		dppB [Mycobacterium tuberculosis]
2097	8516281 (1801, 1802)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		UNCLASSIFIED	1050
		ORF2 [Canis familiaris]
2098	10249120 (4117, 4118)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		UNCLASSIFIED	1001
		ORF2 [Canis familiaris]
2099	65652525 (4655, 4656)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		UNCLASSIFIED	1051
		ORF2 [Canis familiaris]
2100	78094837 (6731, 6732)	Novel Protein sim. GBank gi|2981631|dbj|BAA25253.1| - (AB012223)		UNCLASSIFIED	1039
		ORF2 [Canis familiaris]
2101	12904356 (3471, 3472)	Novel Protein sim. GBank gi|2982245 (AF051205) - hypothetical protein		UNCLASSIFIED	1028, 1047
		[Picea mariana]
2102	10198085 (6605, 6606)	Novel Protein sim. GBank gi|2982986 (AE000682) - putative protein		UNCLASSIFIED	1001
		[Aquifex aeolicus]
2103	39575224 (5485, 5486)	Novel Protein sim. GBank gi|2995313|emb|CAA18341| - (AL022268)		UNCLASSIFIED	1028
		ribonucleotide reductase [Streptomyces coelicolor]
2104	70637364 (657, 658)	Novel Protein sim. GBank gi|3006156|emb|CAA18397| - (AL022299)		UNCLASSIFIED	1046
		putative serine palmitoyltransferase [Schizosaccharomyces pombe]
2105	25239501 (2863, 2864)	Novel Protein sim. GBank gi|3024056|sp|Q63416|ITH3_RAT - INTER-		UNCLASSIFIED	1007
		ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3 PRECURSOR (ITI
		HEAVY CHAIN H3)
2106	80090827 (6553, 6554)	Novel Protein sim. GBank gi|3025235|sp|P75978|YMFN_ECOLI -		UNCLASSIFIED	1002, 1004, 1015
		HYPOTHETICAL 50.9 KD PROTEIN IN INTE-PIN INTERGENIC REGION
2107	66727476 (3173, 3174)	Novel Protein sim. GBank gi|3025268|sp|P76585|YPHG_ECOLI -		UNCLASSIFIED	1046
		HYPOTHETICAL 127.3 KD PROTEIN IN CSIE-GLYA INTERGENIC
		REGION
2108	86689445 (8563, 8564)	Novel Protein sim. GBank gi|3043598|dbj|BAA25463| - (AB011109)		UNCLASSIFIED	1023
		KIAA0537 protein [Homo sapiens]
2109	78898885 (2055, 2056)	Novel Protein sim. GBank gi|3043634|dbj|BAA25481| - (AB011127)		UNCLASSIFIED	1015
		KIAA0555 protein [Homo sapiens]
2110	11356683 (1397, 1398)	Novel Protein sim. GBank gi|3080425|emb|CAA18744.1| - (AL022604)		UNCLASSIFIED	1055
		putative protein [Arabidopsis thaliana]
2111	86623883 (1203, 1204)	Novel Protein sim. GBank gi|30851|emb|CAA44287| - (X62421)		UNCLASSIFIED	1044
		homologue to E. coli DnaJ protein [Homo sapiens]
2112	29143504 (8655, 8656)	Novel Protein sim. GBank gi|3114594 (AF041377) - cell death activator		UNCLASSIFIED	1002, 1014
		CIDE-B [Mus musculus]
2113	29346021 (57, 58)	Novel Protein sim. GBank gi|3122400|sp|O35682|MUG_MOUSE -		UNCLASSIFIED	1020
		MYELOID UPREGULATED PROTEIN
2114	11086263 (1867, 1868)	Novel Protein sim. GBank gi|3122897|sp|O06284|SYK_MYCTU - LYSYL-		UNCLASSIFIED	1003
		TRNA SYNTHETASE (LYSINE-TRNA LIGASE) (LYSRS)
2115	17891620 (1069, 1070)	Novel Protein sim. GBank gi|3122933|sp|Q23623|TGT_CAEEL -		UNCLASSIFIED	1015
		PUTATIVE QUEUINE TRNA-RIBOSYLTRANSFERASE (TRNA-GUANINE
		TRANSGLYCOSYLASE) (GUANINE INSERTION ENZYME)
2116	95105734 (3179, 3180)	Novel Protein sim. GBank gi|3128315 (AF010496) - potential secretion		UNCLASSIFIED	1008
		ATP-binding protein [Rhodobacter capsulatus]
2117	20623991 (1411, 1412)	Novel Protein sim. GBank gi|3130050|emb|CAA18995| - (AL023518)		UNCLASSIFIED	1003
		hypothetical protein [Schizosaccharomyces pombe]
2118	82460088 (8443, 8444)	Novel Protein sim. GBank gi|3183443|sp|Q46861|YGIQ_ECOLI -		UNCLASSIFIED	1001, 1031
		HYPOTHETICAL 46.9 KD PROTEIN IN METC-SUFI INTERGENIC
		REGION
2119	78796862 (4093, 4094)	Navel Protein sim. GBank gi|3192897 (AF066071) - SP85; PsB		UNCLASSIFIED	1024
		[Dictyostelium discoldeum]
2120	28491134 (4287, 4288)	Novel Protein sim. GBank gi|3192897 (AF066071) - SP85; PsB		UNCLASSIFIED	1006
		[Dictyostelium discoldeum]
2121	28384987 (4767, 4768)	Novel Protein sim. GBank gi|320866|pir||S31262 - TYB4 protein - yeast		UNCLASSIFIED	1015
		(Saccharomyces cerevisiae) transposon Ty4
2122	80055560 (3731, 3732)	Novel Protein sim. GBank gi|3256517|dbj|BAA29200.1| - (AP000001)		UNCLASSIFIED	1003
		249aa long hypothetical protein [Pyrococcus horikoshil]
2123	20438347 (3831, 3832)	Novel Protein sim. GBank gi|3257180|dbj|BAA29863| - (AP000003) 391aa		UNCLASSIFIED	1022
		long hypothetical aspartate aminotransferase [Pyrococcus horikoshil]
2124	95103910 (4049, 4050)	Novel Protein sim. GBank gi|3269293|emb|CAA19726| - (AL030978)		UNCLASSIFIED	1002
		putative protein [Arabidopsis thaliana]
2125	20465424 (8395, 8396)	Novel Protein sim. GBank gi|3287868|sp|P87058|LAH1_SCHPO - LA		UNCLASSIFIED	1008
		PROTEIN HOMOLOG (LA RIBONUCLEOPROTEIN) (LA AUTOANTIGEN
		HOMOLOG)
2126	11360195 (8501, 8502)	Novel Protein sim. GBank gi|3294241|emb|CAA19854| - (AL031031)		UNCLASSIFIED	1004
		phosphatidylglycerophosphate synthase [Streptomyces coelicolor]
2127	71805911 (3683, 3684)	Novel Protein sim. GBank gi|3328385 (AF076956) - prenylated SNARE		UNCLASSIFIED	1024
		protein Ykt6 [Mus musculus]
2128	79635381 (5843, 5844)	Novel Protein sim. GBank gi|3341658|emb|CAA13172| - (AJ231130) z70r		UNCLASSIFIED	1001
		[Vibrio cholerae]
2129	37802734 (4537, 4538)	Novel Protein sim. GBank gi|3342823 (AF076955) - eukaryotic translation		UNCLASSIFIED	1055
		initiation factor p28 subunit [Zea mays]
2130	86685844 (5553, 5554)	Novel Protein sim. GBank gi|3378420 (AF079317) - unknown		UNCLASSIFIED	1026
		[Sphingomonas aromaticivorans]
2131	11295400 (3297, 3298)	Novel Protein sim. GBank gi|3413320|emb|CAA06915| - (AJ006215) CMP		UNCLASSIFIED	1003
		N-acetylneuraminic acid synthetase [Mus musculus]
2132	78460013 (6171, 6172)	Novel Protein sim. GBank gi|3413408|emb|CAA20269| - (AL031231)		UNCLASSIFIED	1024
		ATP/GTP binding protein [Streptomyces coelicolor]
2133	25250036 (4055, 4056)	Novel Protein sim. GBank gi|3426039 (AC005168) - unknown protein		UNCLASSIFIED	1041
		[Arabidopsis thaliana]
2134	37061554 (8677, 8678)	Novel Protein sim. GBank gi|3435201 (AF072467) - unknown [Homo		UNCLASSIFIED	1047
		sapiens]
2135	79173375 (1243, 1244)	Novel Protein sim. GBank gi|3449254|emb|CAA20398| - (AL031317)		UNCLASSIFIED	1003
		hypothetical protein SC6G4.20c [Streptomyces coelicolor]
2136	13518323 (6869, 6870)	Novel Protein sim. GBank gi|3449269|emb|CAA20413| - (AL031317)		UNCLASSIFIED	1022
		hypothetical protein SC6G4.35 [Streptomyces coelicolor]
2137	30576868 (4611, 4612)	Novel Protein sim. GBank gi|3495|emb|CAA27837| - (X04289) CDC39		UNCLASSIFIED	1007
		gene product (aa 1-834) [Saccharomyces cerevisiae]
2138	10317780 (3011, 3012)	Novel Protein sim. GBank gi|3510629 (AF047828) - syringomycin		UNCLASSIFIED	1021
		synthetase [Pseudomonas syringae pv. syringae]
2139	87462072 (3347, 3348)	Novel Protein sim. GBank gi|3582335 (AC005496) - unknown protein		UNCLASSIFIED	1023
		[Arabidopsis thaliana]
2140	86677733 (3957, 3958)	Novel Protein sim. GBank gi|3639077 (AF090113) - AMPA receptor		UNCLASSIFIED	1045
		binding protein [Rattus norvegicus]
2141	27261992 (4743, 4744)	Novel Protein sim. GBank gi|3688173|emb|CAA21201| - (AL031804)		UNCLASSIFIED	1020
		putative protein [Arabidopsis thaliana]
2142	20292030 (4839, 4840)	Novel Protein sim. GBank gi|3722226 (AF058711) - essential Gc protein		UNCLASSIFIED	1031
		[Neisseria gonorrhoeae]
2143	5827990 (1833, 1834)	Novel Protein sim. GBank gi|3738310 (AC005309) - putative nuclear		UNCLASSIFIED	1055
		protein [Arabidopsis thaliana]
2144	79614206 (7739, 7740)	Novel Protein sim. GBank gi|3786009 (AC005499) - unknown protein		UNCLASSIFIED	1002
		[Arabidopsis thaliana]
2145	20466623 (4871, 4872)	Novel Protein sim. GBank gi|3790677 (AF099002) - similar to human 5′-		UNCLASSIFIED	1008
		nucleotidase (SW: P49902) [Caenorhabditis elegans]
2146	78674885 (5371, 5372)	Novel Protein sim. GBank gi|3818539 (AF071506) - TIMELESS protein		UNCLASSIFIED	1015
		[Mus musculus]
2147	11690248 (2181, 2182)	Novel Protein sim. GBank gi|382209|prf||1819268A - tRNA guanine		UNCLASSIFIED	1028
		transglycosylase [Zymomonas mobills]
2148	17282819 (2423, 2424)	Novel Protein sim. GBank gi|3860634|emb|CAA14535| - (AJ235270)		UNCLASSIFIED	1036
		DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE
		(dgtP) [Rickettsia prowazekll]
2149	21424850 (2033, 2034)	Novel Protein sim. GBank gi|3873550|emb|CAA22127| - (AL033534)		UNCLASSIFIED	1020, 1022, 1031
		serine-rich protein [Schizosaccharomyces pombe]
2150	79259168 (1755, 1756)	Novel Protein sim. GBank gi|3875273|emb|CAB02862| - (Z81051)		UNCLASSIFIED	1022, 1027, 1038
		predicted using Genefinder; Similarity in 3′ end to Human KIAA0173
		protein (TR: Q14679); cDNA EST-EMBL: D33319 comes from this gene;
		cDNA EST EMBL: D34000 comes from this gene; cDNA EST
		EMBL: D36110 comes from this gene; c . . .
2151	16708710 (4739, 4740)	Novel Protein sim. GBank gi|3875796|emb|CAA97788| - (Z73425)		UNCLASSIFIED	1021
		Similarity to Yeast hypothetical YIK9 protein (SW: YIK9_YEAST); cDNA
		EST EMBL: T01252 comes from this gene; cDNA EST EMBL: D33205
		comes from this gene; cDNA EST EMBL: D33955 comes from this gene;
		cDNA EST EMBL: D35484 comes . . .
2152	13509387 (2847, 2848)	Novel Protein sim. GBank gi|3879239|emb|CAA92009| - (Z68010)		UNCLASSIFIED	1001
		T01C1.3 [Caenorhabditis elegans]
2153	9398461 (7129, 7130)	Novel Protein sim. GBank gi|3915465|sp|P77254|YFGK_ECOLI -		UNCLASSIFIED	1015, 1026
		HYPOTHETICAL GTP-BINDING PROTEIN IN XSEA-HISS INTERGENIC
		REGION
2154	87451985 (4765, 4766)	Novel Protein sim. GBank gi|3928084 (AC005770) - retrotransposon-like		UNCLASSIFIED	1023
		protein [Arabidopsis thaliana]
2155	78376913 (4005, 4006)	Novel Protein sim. GBank gi|3928726|emb|CAA22222| - (AL034355)		UNCLASSIFIED	1006, 1024
		hypothetical protein SCD78.17c [Streptomyces coelicolor]
2156	20636325 (683, 684)	Novel Protein sim. GBank gi|3929022 (AF057696) - LspB [Haemophilus		UNCLASSIFIED	1022
		ducreyl]
2157	79573718 (7583, 7584)	Novel Protein sim. GBank gi|3986409 (AF033350) - CDCREL-1 homolog		UNCLASSIFIED	1014, 1015
		[Mus musculus]
2158	78674796 (8627, 8628)	Novel Protein sim. GBank gi|399339|sp|P30144|DAGA_ALTHA - NA(+)-		UNCLASSIFIED	1015
		LINKED D-ALANINE GLYCINE PERMEASE
2159	80217591 (4405, 4406)	Novel Protein sim. GBank gi|4000|emb|CAA38222| - (X54324) 43 kD		UNCLASSIFIED	1002, 1003, 1004, 1006,
		protein [Saccharomyces cerevisiae]			1008, 1020, 1022, 1023,
					1024, 1031, 1035, 1036
2160	78206888 (277, 278)	Novel Protein sim. GBank gi|400533|sp|Q02373|NIDM_BOVIN - NADH-		UNCLASSIFIED	1020
		UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT (COMPLEX I-
		PDSW) (CI-PDSW)
2161	20458975 (7509, 7510)	Novel Protein sim. GBank gi|401542|sp|P31064|YEDE_ECOLI -		UNCLASSIFIED	1008
		HYPOTHETICAL 44.4 KD PROTEIN IN AMYA-FLIE INTERGENIC
		REGION (ORF 48)
2162	30251079 (2965, 2966)	Novel Protein sim. GBank gi|401561|sp|P31120|MRSA_ECOLI - MRSA		UNCLASSIFIED	1041
		PROTEIN
2163	20443675 (6371, 6372)	Novel Protein sim. GBank gi|4050087 (AF109907) - S164 [Homo sapiens]		UNCLASSIFIED	1022
2164	56653786 (1765, 1766)	Novel Protein sim. GBank gi|406767|emb|CAA52645| - (X74551) MAC1		UNCLASSIFIED	1002, 1006, 1020, 1021
		protein [Saccharomyces cerevisiae]
2165	29238378 (469, 470)	Novel Protein sim. GBank gi|4129|emb|CAA30440| - (X07558) URF		UNCLASSIFIED	1001, 1003, 1020, 1031,
		[Saccharomyces cerevisiae]			1041
2166	20466807 (6363, 6364)	Novel Protein sim. GBank gi|4139232|gb|AAD05169.1| - (AF110185)		UNCLASSIFIED	1008
		unknown [Burkholderia pseudomallel]
2167	78977368 (8939, 8940)	Novel Protein sim. GBank gi|414081|emb|CAA53202| - (X75449) RAS		UNCLASSIFIED	1002
		GTPase-activating protein [Saccharomyces cerevisiae]
2168	80209391 (2027, 2028)	Novel Protein sim. GBank gi|4155476 (AE001519) - putative [Helicobacter		UNCLASSIFIED	1031
		pylori J99]
2169	82108484 (2613, 2614)	Novel Protein sim. GBank gi|416658|sp|P32448|ASF2_YEAST - ANTI-		UNCLASSIFIED	1001, 1002, 1003, 1004,
		SILENCING PROTEIN 2			1006, 1007, 1008, 1010,
					1014, 1015, 1020, 1021,
					1022, 1024, 1025, 1026,
					1028, 1031, 1035, 1036,
					1041
2170	80219578 (4091, 4092)	Novel Protein sim. GBank gi|416762|sp|P32797|CC13_YEAST - CELL		UNCLASSIFIED	1002, 1003, 1004, 1008,
		DIVISION CONTROL PROTEIN 13			1015, 1020, 1022, 1031
2171	11798406 (931, 932)	Novel Protein sim. GBank gi|416769|sp|P32558|CC68_YEAST - CELL		UNCLASSIFIED	1023
		DIVISION CONTROL PROTEIN 68
2172	27366317 (2519, 2520)	Novel Protein sim. GBank gi|416911|sp|P32461|DPH2_YEAST -		UNCLASSIFIED	1020
		DIPHTERIA TOXIN RESISTANCE PROTEIN 2
2173	20711747 (4629, 4630)	Novel Protein sim. GBank gi|416911|sp|P32461|DPH2_YEAST -		UNCLASSIFIED	1020
		DIPHTERIA TOXIN RESISTANCE PROTEIN 2
2174	11818906 (2093, 2094)	Novel Protein sim. GBank gi|417116|sp|P32396|HEMZ_BACSU -		UNCLASSIFIED	1003
		FERROCHELATASE (PROTOHEME FERRO-LYASE) (HEME
		SYNTHETASE)
2175	14996440 (6761, 6762)	Novel Protein sim. GBank gi|417457|sp|P32767|PDR6_YEAST -		UNCLASSIFIED	1022
		PLEIOTROPIC DRUG RESISTANCE REGULATORY PROTEIN 6
2176	20483947 (6801, 6802)	Novel Protein sim. GBank gi|417478|sp|P32522|PT09_YEAST - PET309		UNCLASSIFIED	1008
		PROTEIN PRECURSOR
2177	8234455 (3893, 3894)	Novel Protein sim. GBank gi|418501|sp|P32159|YIIP_ECOLI -		UNCLASSIFIED	1020
		HYPOTHETICAL 32.9 KD PROTEIN IN CPXA-PFKA INTERGENIC
		REGION
2178	57294505 (6107, 6108)	Novel Protein sim. GBank gi|418609|sp|P32464|YKS9_YEAST -		UNCLASSIFIED	1003, 1008, 1015, 1022,
		HYPOTHETICAL 45.9 KD PROTEIN IN CNB1-PXA2 INTERGENIC			1023
		REGION
2179	21635624 (4843, 4844)	Novel Protein sim. GBank gi|4200042|dbj|BAA74460| - (AB022715)		UNCLASSIFIED	1015, 1036
		exopolyphosphatase [Pseudomonas aeruginosa]
2180	91215888 (1449, 1450)	Novel Protein sim. GBank gi|423830|pir||A45690 - transactivator EBNA-2 -		UNCLASSIFIED	1003, 1014, 1051
		Herpesvirus papio HVP
2181	20123764 (875, 876)	Novel Protein sim. GBank gi|4322004|gb|AAD15907| - (AF069392) polar		UNCLASSIFIED	1031
		flagellar switch protein [Vibrio parahaemolyticus]
2182	88094506 (4131, 4132)	Novel Protein sim. GBank gi|433645|emb|CAA53420| - (X75781) D513		UNCLASSIFIED	1003, 1004, 1010, 1020,
		[Saccharomyces cerevisiae]			1022, 1041, 1051
2183	6753363 (2721, 2722)	Novel Protein sim. GBank gi|437726 (L23753) - MNN1 [Saccharomyces		UNCLASSIFIED	1020
		cerevisiae]
2184	10331456 (7645, 7646)	Novel Protein sim. GBank gi|4406780|gb|AAD20090| - (AC006532)		UNCLASSIFIED	1002
		putative multispanning membrane protein [Arabidopsis thaliana]
2185	78970614 (3111, 3112)	Novel Protein sim. GBank gi|441155 (L22219) - ransmission-blocking		UNCLASSIFIED	1014, 1024
		target antigen [Plasmodium falciparum]
2186	39709654 (5379, 5380)	Novel Protein sim. GBank gi|4415936|gb|AAD20166| - (AC006418)		UNCLASSIFIED	1002, 1041
		unknown protein [Arabidopsis thaliana]
2187	78751849 (7125, 7126)	Novel Protein sim. GBank gi|4416305|gb|AAD20310| - (AF105716)		UNCLASSIFIED	1002, 1015, 1020, 1024
		hypothetical protein [Zea mays]
2188	78361431 (6365, 6366)	Novel Protein sim. GBank gi|4455171|emb|CAB36703| - (AL035521)		UNCLASSIFIED	1006, 1024, 1043
		hypothetical protein [Arabidopsis thaliana]
2189	80236049 (8061, 8062)	Novel Protein sim. GBank gi|4468310|emb|CAB37991| - (AL031432)		UNCLASSIFIED	1004
		dJ465N24.1 (PUTATIVE novel protein similar to predicted yeast and worm
		proteins) [Homo sapiens]
2190	79831273 (5507, 5508)	Novel Protein sim. GBank gi|4468699|emb|CAB38153.1| - (AL035591)		UNCLASSIFIED	1021
		putative integral membrane export protein [Streptomyces coelicolor]
2191	71088503 (6521, 6522)	Novel Protein sim. GBank gi|4468699|emb|CAB38153.1| - (AL035591)		UNCLASSIFIED	1050
		putative integral membrane export protein [Streptomyces coelicolor]
2192	27972146 (7167, 7168)	Novel Protein sim. GBank gi|4493746|emb|CAB39088.1| - (AL034358)		UNCLASSIFIED	1020
		predicted using hexExon; L4830.10, Hypothetical protein, len: 816 aa
		[Leishmania major]
2193	54696540 (8211, 8212)	Novel Protein sim. GBank gi|4502037|ref|NP_003739.1|pALDH -		UNCLASSIFIED	1038
		UNKNOWN
2194	27847651 (1287, 1288)	Novel Protein sim. GBank gi|4502351|ref|NP_001692.1|pBAAT - bile acid		UNCLASSIFIED	1020, 1031
		Coenzyme A: amino acid N-acyltransferase; glycine N-choloyltransferase
2195	56657161 (7565, 7566)	Novel Protein sim. GBank gi|4504161|ref|NP_002083.1|pGRSF - G-rich		UNCLASSIFIED	1006
		RNA sequence binding factor 1
2196	71490095 (8531, 8532)	Novel Protein sim. GBank gi|4504601|ref|NP_000865.1|pIFNA - interferon		UNCLASSIFIED	1010, 1039
		(alpha, beta and omega) receptor 2
2197	78400768 (7077, 7078)	Novel Protein sim. GBank gi|4505201|ref|NP_002411.1|pMLSN -		UNCLASSIFIED	1035
		melastatin 1
2198	79843360 (8365, 8366)	Novel Protein sim. GBank gi|4505323|ref|NP_003932.1|pN-WA -		UNCLASSIFIED	1006
		UNKNOWN
2199	30510015 (6447, 6448)	Novel Protein sim. GBank gi|4505891|ref|NP_001075.1|pPLOD -		UNCLASSIFIED	1014
		UNKNOWN
2200	80219711 (1795, 1796)	Novel Protein sim. GBank gi|4507367|ref|NP_003182.1|pTARS - threonyl-		UNCLASSIFIED	1002, 1004, 1020
		tRNA synthetase
2201	28480351 (5845, 5846)	Novel Protein sim. GBank gi|4507909|ref|NP_000368.1|pWAS| - Wiskott-		UNCLASSIFIED	1020
		Aldrich syndrome (ecezema-thrombocytopenla)
2202	78720067 (7947, 7948)	Novel Protein sim. GBank gi|451544 (U04267) - proline-rich cell wall		UNCLASSIFIED	1027
		protein [Gossypium barbadense]
2203	80029393 (2885, 2886)	Novel Protein sim. GBank gi|4539171|emb|CAB39700.1| - (AL049485)		UNCLASSIFIED	1003, 1004, 1006, 1031
		conserved hypothetical protein [Streptomyces coelicolor]
2204	20372397 (5837, 5838)	Novel Protein sim. GBank gi|4539386|emb|CAB37452.1| - (AL035526)		UNCLASSIFIED	1020
		extensin-like protein [Arabidopsis thaliana]
2205	65851027 (6291, 6292)	Novel Protein sim. GBank gi|4539386|emb|CAB37452.1| - (AL035526)		UNCLASSIFIED	1035
		extensin-like protein [Arabidopsis thaliana]
2206	79457146 (1849, 1850)	Novel Protein sim. GBank gi|4539582|emb|CAB38501.1| - (AL035636)		UNCLASSIFIED	1024, 1028
		putative sodium/proton antiporter [Streptomyces coelicolor]
2207	11076626 (6669, 6670)	Novel Protein sim. GBank gi|4579748|dbj|BAA75214.1| - (AB017484)		UNCLASSIFIED	1008
		tachylectin-3 [Tachypleus tridentatus]
2208	79821967 (6821, 6822)	Novel Protein sim. GBank gi|4580331|emb|CAB40107.1| - (AJ001206)		UNCLASSIFIED	1031
		putative glycogen debranching enzyme [Streptomyces coelicolor]
2209	28483211 (9027, 9028)	Novel Protein sim. GBank gi|4586056|gb|AAD25674.1|AC00702 -		UNCLASSIFIED	1002
		(AC007020) unknown protein [Arabidopsis thaliana]
2210	79825487 (3997, 3998)	Novel Protein sim. GBank gi|4586058|gb|AAD25676.1|AC00702 -		UNCLASSIFIED	1041
		(AC007020) unknown protein [Arabidopsis thaliana]
2211	79167936 (1587, 1588)	Novel Protein sim. GBank gi|4587990|gb|AAD25931.1|AF08527 -		UNCLASSIFIED	1028, 1047
		(AF085279) hypothetical protein [Arabidopsis thaliana]
2212	27306125 (5175, 5176)	Novel Protein sim. GBank gi|4604|emb|CAA49191| - (X69394) TBF1		UNCLASSIFIED	1002, 1021
		protein [Saccharomyces cerevisiae]
2213	80218399 (8923, 8924)	Novel Protein sim. GBank gi|461915|sp|P33894|DAP1_YEAST -		UNCLASSIFIED	1003, 1004, 1006, 1020,
		DIPEPTIDYL AMINOPEPTIDASE A (DPAP A) (YSCIV)			1023, 1031, 1041
2214	71764092 (323, 324)	Novel Protein sim. GBank gi|462024|sp|P25087|ERG6_YEAST -		UNCLASSIFIED	1002
		DELTA(24)-STEROL C-METHYLTRANSFERASE
2215	28781806 (767, 768)	Novel Protein sim. GBank gi|462168|sp|P33892|GCN1_YEAST -		UNCLASSIFIED	1024
		TRANSLATIONAL ACTIVATOR GCN1
2216	79854885 (7311, 7312)	Novel Protein sim. GBank gi|462264|sp|P25519|HFLX_ECOLI - GTP-		UNCLASSIFIED	1021
		BINDING PROTEIN HFLX
2217	78438796 (3395, 3396)	Novel Protein sim. GBank gi|462489|sp|P33231|LLDP_ECOLI - L-		UNCLASSIFIED	1051
		LACTATE PERMEASE
2218	9939622 (9041, 9042)	Novel Protein sim. GBank gi|462663|sp|Q05869|MUTY_SALTY - A/G-		UNCLASSIFIED	1015
		SPECIFIC ADENINE GLYCOSYLASE
2219	29259652 (3793, 3794)	Novel Protein sim. GBank gi|464255|sp|P34943|NUEM_BOVIN - NADH-		UNCLASSIFIED	1024
		UBIQUINONE OXIDOREDUCTASE 39 KD SUBUNIT PRECURSOR
		(COMPLEX I-39 KD) (CI-39 KD)
2220	46726384 (7597, 7598)	Novel Protein sim. GBank gi|464376|sp|Q05017|PHLX_RABIT -		UNCLASSIFIED	1051
		PHOSPHOLIPASE ADRAB-B PRECURSOR
2221	80042752 (1147, 1148)	Novel Protein sim. GBank gi|465721|sp|P34252|YKK8_YEAST -		UNCLASSIFIED	1002, 1031
		HYPOTHETICAL 52.3 KD PROTEIN IN HAP4-AAT1 INTERGENIC
		REGION
2222	27837569 (1027, 1028)	Novel Protein sim. GBank gi|466116|sp|P35193|YOI2_YEAST -		UNCLASSIFIED	1008, 1020, 1036
		HYPOTHETICAL 47.6 KD PROTEIN IN ADH1-IRA2 INTERGENIC
		REGION
2223	91228712 (2711, 2712)	Novel Protein sim. GBank gi|466152|sp|P34653|YOT7_CAEEL -		UNCLASSIFIED	1004, 1008
		HYPOTHETICAL 76.2 KD PROTEIN ZK632.7 IN CHROMOSOME III
2224	16327135 (8717, 8718)	Novel Protein sim. GBank gi|4680180|gb|AAD27548.1|AF11170 -		UNCLASSIFIED	1008
		(AF111709) polyprotein [Oryza sativa subsp. indica]
2225	23308893 (6287, 6288)	Novel Protein sim. GBank gi|4680661|gb|AAD27720.1|AF13294 -		UNCLASSIFIED	1050
		(AF132945) CGI-11 protein [Homo sapiens]
2226	28985623 (4533, 4534)	Novel Protein sim. GBank gi|472525 (L31766) - synthetic lethal 39		UNCLASSIFIED	1024
		[Saccharomyces cerevisiae]
2227	19532750 (6607, 6608)	Navel Protein sim. GBank gi|4760782|dbj|BAA77399.1| - (A8025413) Ten-		UNCLASSIFIED	1035
		m4 [Mus musculus]
2228	54539122 (8817, 8818)	Novel Protein sim. GBank gi|476794|pir||A40678 - T-cell adhesion		UNCLASSIFIED	1037
		receptor CD2 homolog - African swine fever virus
2229	78392965 (5091, 5092)	Novel Protein sim. GBank gi|480450|pir||S36884 - ketol-acid		UNCLASSIFIED	1006
		reductolsomerase (EC 1.1.1.86) - Arabidopsis thaliana
2230	80245872 (6351, 6352)	Novel Protein sim. GBank gi|4808394|emb|CAB42726.1| - (AL049826)		UNCLASSIFIED	1004, 1007, 1022
		putative membrane protein [Streptomyces coelicolor]
2231	25322209 (4127, 4128)	Novel Protein sim. GBank gi|4827069|ref|NP_005086.1|pZNF2 - Zinc		UNCLASSIFIED	1007
		finger protein 262
2232	86472489 (5287, 5288)	Novel Protein sim. GBank gi|482818 (U08864) - unknown [Paracoccus		UNCLASSIFIED	1017
		denitrificans]
2233	11175105 (8541, 8542)	Novel Protein sim. GBank gi|4868437|gb|AAD31316.1|AF14405 -		UNCLASSIFIED	1020
		(AF144054) apoptosis related protein APR-4 [Homo sapiens]
2234	79633410 (2889, 2890)	Novel Protein sim. GBank gi|4887120|gb|AAD32200.1| - (AF134855)		UNCLASSIFIED	1036
		transcriptional regulator [Salmonella typhimurium]
2235	32174564 (4581, 4582)	Novel Protein sim. GBank gi|4887211|gb|AAD32237.1|AF14744 -		UNCLASSIFIED	1003, 1036
		(AF147449) penicillin-binding protein 1B [Pseudomonas aeruginosa]
2236	78791211 (4269, 4270)	Novel Protein sim. GBank gi|4902474|emb|CAB43554.1| - (AJ131243) 5′-		UNCLASSIFIED	1007
		nucleotidase [Columba livia]
2237	85808202 (6767, 6768)	Novel Protein sim. GBank gi|4902699|emb|CAB42442.1| - (AL049784)		UNCLASSIFIED	1014, 1020, 1035
		hypothetical protein [Homo sapiens]
2238	83001442 (1359, 1360)	Novel Protein sim. GBank gi|4902730|emb|CAB43533.1| - (AJ238889)		UNCLASSIFIED	1050
		multidrug resistance-associated protein 7 [Homo sapiens]
2239	8519496 (6729, 6730)	Novel Protein sim. GBank gi|4929538|gb|AAD34029.1|AF15136 -		UNCLASSIFIED	1003
		(AF151367) Olg-1 bHLH protein [Rattus norvegicus]
2240	30381809 (2303, 2304)	Novel Protein sim. GBank gi|4929759|gb|AAD34140.1|AF15190 -		UNCLASSIFIED	1020
		AF151903) CGI-145 protein [Homo sapiens]
2241	78523463 (6759, 6760)	Novel Protein sim. GBank gi|4981756|gb|AAD36279.1|AE00177 -		UNCLASSIFIED	1006
		(AE001777) maltose ABC transporter, periplasmic maltose-binding protein
		[Thermotoga maritima]
2242	13519504 (4619, 4620)	Novel Protein sim. GBank gi|5002553|gb|AAD37457.1| - (AF074603)		UNCLASSIFIED	1022
		NonF [Streptomyces griseus subsp. griseus]
2243	87115363 (5095, 5096)	Novel Protein sim. GBank gi|5006424|gb|AAD37493.1|AF10916 -		UNCLASSIFIED	1016
		(AF109162) HmuT precursor [Corynebacterium diphtheriae]
2244	20612645 (475, 476)	Novel Protein sim. GBank gi|5019354|emb|CAB44407.1| - (AL078610)		UNCLASSIFIED	1020
		putative substrate-binding periplasmic transport protein [Streptomyces
		coelicolor]
2245	17900660 (3663, 3664)	Novel Protein sim. GBank gi|5031665|ref|NP_005500.1|pDMXL - Dmx-like 1		UNCLASSIFIED	1036
2246	20467921 (473, 474)	Novel Protein sim. GBank gi|5042280|emb|CAB44534.1| - (AL078618)		UNCLASSIFIED	1008
		putative electron transfer oxidoreductase [Streptomyces coelicolor]
2247	32152796 (1437, 1438)	Novel Protein sim. GBank gi|5107182|gb|AAD40003.1|AF15009 -		UNCLASSIFIED	1036
		(AF150097) small zinc finger-like protein [Emericella nidulans]
2248	29272255 (5925, 5926)	Novel Protein sim. GBank gi|515507 (U12027) - Sok1p [Saccharomyces		UNCLASSIFIED	1003, 1004, 1008, 1022,
		cerevisiae]			1041
2249	81215365 (1861, 1862)	Novel Protein sim. GBank gi|520476 (U09129) - Mkt1p [Saccharomyces		UNCLASSIFIED	1002, 1003, 1004, 1006,
		cerevisiae]			1007, 1008, 1010, 1014,
					1015, 1020, 1021, 1022,
					1023, 1024, 1028, 1031,
					1036, 1041, 1046, 1051
2250	80250296 (521, 522)	Novel Protein sim. GBank gi|5257279|dbj|BAA81778.1| - (AP000364)		UNCLASSIFIED	1004
		Similar to Transposon MAGGY gag and pol gene homologues. (L35053)
		[Oryza sativa]
2251	11582392 (6651, 6652)	Novel Protein sim. GBank gi|5262203|emb|CAB45800.1| - (AL080252)		UNCLASSIFIED	1003
		nodulin-like protein [Arabidopsis thaliana]
2252	37815191 (4347, 4348)	Novel Protein sim. GBank gi|5420387|emb|CAB46679.1| - (AJ243459)		UNCLASSIFIED	1055
		proteophosphoglycan [Leishmanla major]
2253	80486175 (6683, 6684)	Novel Protein sim. GBank gi|5420389|emb|CAB46680.1| - (AJ243460)		UNCLASSIFIED	1010
		proteophosphoglycan [Leishmanla major]
2254	16308001 (5335, 5336)	Novel Protein sim. GBank gi|548652|sp|Q02722|Q300_MOUSE -		UNCLASSIFIED	1051
		PROTEIN Q300
2255	11129191 (5611, 5612)	Novel Protein sim. GBank gi|548652|sp|Q02722|Q300_MOUSE -		UNCLASSIFIED	1020
		PROTEIN Q300
2256	78790951 (739, 740)	Novel Protein sim. GBank gi|549009|sp|P36150|SUMT_YEAST -		UNCLASSIFIED	1007
		PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN
		III METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHYLASE)
		(UROM)
2257	80216185 (437, 438)	Novel Protein sim. GBank gi|549614|sp|P36137|YK24_YEAST -		UNCLASSIFIED	1004, 1006, 1008, 1020,
		HYPOTHETICAL 51.0 KD PROTEIN IN GAP1-NAP1 INTERGENIC			1022, 1031, 1035
		REGION
2258	29361783 (5205, 5206)	Novel Protein sim. GBank gi|549636|sp|P36158|YK58_YEAST -		UNCLASSIFIED	1007, 1024, 1031
		HYPOTHETICAL 68.3 KD PROTEIN IN SIS2-MTD1 INTERGENIC
		REGION
2259	80071630 (7307, 7308)	Novel Protein sim. GBank gi|549648|sp|P36170|YK82_YEAST -		UNCLASSIFIED	1004, 1015, 1020
		HYPOTHETICAL 122.2 KD PROTEIN IN SIR1 3′REGION PRECURSOR
2260	80245834 (85, 86)	Novel Protein sim. GBank gi|549679|sp|P35734|YKF2_YEAST -		UNCLASSIFIED	1031
		HYPOTHETICAL 32.1 KD PROTEIN IN NUP120-CSE4 INTERGENIC
		REGION
2261	27845802 (6077, 6078)	Novel Protein sim. GBank gi|549689|sp|P36088|YKG9_YEAST -		UNCLASSIFIED	1020, 1031
		HYPOTHETICAL 19.7 KD PROTEIN IN LHS1-NUP100 INTERGENIC
		REGION
2262	8498866 (3829, 3830)	Novel Protein sim. GBank gi|549754|sp|P28273|YKV5_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 140.4 KD PROTEIN IN URA1-DOA1 INTERGENIC
		REGION
2263	27210480 (385, 386)	Novel Protein sim. GBank gi|549766|sp|P36110|YKZ3_YEAST -		UNCLASSIFIED	1024
		HYPOTHETICAL 33.8 KD PROTEIN PRECURSOR IN FOX2-YPT52
		INTERGENIC REGION
2264	79810937 (5457, 5458)	Novel Protein sim. GBank gi|5531272|emb|CAB50897.1| - (AJ243800)		UNCLASSIFIED	1022
		WSC4 homologue [Kluyveromyces lactis]
2265	80229396 (6345, 6346)	Novel Protein sim. GBank gi|5531366|emb|CAB50998.1| - (AL096852)		UNCLASSIFIED	1004, 1022
		hypothetical protein [Streptomyces coelicolor A3(2)]
2266	20396935 (9005, 9006)	Novel Protein sim. GBank gi|5639946|gb|AAD45904.1|AF16132 -		UNCLASSIFIED	1008
		(AF161328) histidine kinase CstS [Corynebacterium diphtheriae]
2267	5617688 (4701, 4702)	Novel Protein sim. GBank gi|5668795|gb|AAD46021.1|AC00751 -		UNCLASSIFIED	1055
		(AC007519) EST gb|AA605495 comes from this gene. [Arabidopsis
		thaliana]
2268	86679196 (4373, 4374)	Novel Protein sim. GBank gi|5668814|gb|AAD46040.1|AC00751 -		UNCLASSIFIED	1005
		(AC007519) ESTs gb|H36253 and gb|AA04251 come from this gene.
		[Arabidopsis thaliana]
2269	78903560 (5749, 5750)	Novel Protein sim. GBank gi|5669820|gb|AAD46481.1|AF12474 -		UNCLASSIFIED	1036
		(AF124741) Toll-like receptor 2 [Mus musculus]
2270	11083976 (5043, 5044)	Novel Protein sim. GBank gi|5689405|dbj|BAA82986.1| - (AB028957)		UNCLASSIFIED	1022
		KIAA1034 protein [Homo sapiens]
2271	80088527 (5153, 5154)	Novel Protein sim. GBank gi|5689948|emb|CAB51985.1| - (AL109663)		UNCLASSIFIED	1003
		putative isoleucyl-tRNA synthetase [Streptomyces coelicolor A3(2)]
2272	91232333 (7523, 7524)	Novel Protein sim. GBank gi|5712756|gb|AAD47636.1|AF16079 -		UNCLASSIFIED	1008
		(AF160798) calcium transporter CaT1 [Rattus norvegicus]
2273	52561548 (535, 536)	Novel Protein sim. GBank gi|585529|sp|P38108|MUCB_PSEAE - SIGMA		UNCLASSIFIED	1002
		FACTOR ALGU REGULATORY PROTEIN MUCB PRECURSOR
2274	28782494 (2321, 2322)	Novel Protein sim. GBank gi|586316|sp|P38300|MBA1_YEAST - MBA1		UNCLASSIFIED	1020
		PROTEIN PRECURSOR
2275	80216566 (8765, 8766)	Novel Protein sim. GBank gi|586407|sp|P38206|RFT1_YEAST -		UNCLASSIFIED	1001, 1002, 1003, 1004,
		NUCLEAR DIVISION RFT1 PROTEIN			1006, 1007, 1010, 1015,
					1020, 1021, 1022, 1024,
					1028, 1031, 1041
2276	14995550 (4669, 4670)	Novel Protein sim. GBank gi|586508|sp|P38242|YBS0_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 27.0 KD PROTEIN IN VAL1-HSP26 INTERGENIC
		REGION
2277	80034126 (5179, 5180)	Novel Protein sim. GBank gi|586525|sp|P38258|YBU9_YEAST -		UNCLASSIFIED	1008
		HYPOTHETICAL 14.8 KD PROTEIN IN VPS15-YMC2 INTERGENIC
		REGION
2278	80083735 (2839, 2840)	Novel Protein sim. GBank gi|586543|sp|P38274|YBY3_YEAST -		UNCLASSIFIED	1006, 1020, 1024
		HYPOTHETICAL 95.2 KD PROTEIN IN AGP2-CKS1 INTERGENIC
		REGION
2279	27830651 (7939, 7940)	Novel Protein sim. GBank gi|586871|sp|P37541|YAAT_BACSU -		UNCLASSIFIED	1008
		HYPOTHETICAL 31.2 KD PROTEIN IN XPAC-ABRB INTERGENIC
		REGION
2280	29210919 (3769, 3770)	Novel Protein sim. GBank gi|595413 (U11236) - beta COP		UNCLASSIFIED	1006
		[Saccharomyces cerevisiae]
2281	79912177 (2231, 2232)	Novel Protein sim. Gbank gi|606216 (U18997) - ORF_f176 [Escherichia		UNCLASSIFIED	1002
		coli]
2282	27362875 (7537, 7538)	Novel Protein sim. GBank gi|630206|pir||S40970 - hypothetical protein		UNCLASSIFIED	1002, 1006, 1015
		YCR30 - yeast (Saccharomyces cerevisiae)
2283	79582169 (4125, 4126)	Novel Protein sim. GBank gi|66457|pir||XYPS7A - site-specific DNA-		UNCLASSIFIED	1020
		methyltransferase (adenine-specific) (EC 2.1.1.72) PaeR71 -
		Pseudomonas aeruginosa plasmid pMG7
2284	20724505 (4505, 4506)	Novel Protein sim. GBank gi|699274 (U15183) - ImbE gene product		UNCLASSIFIED	1004
		[Mycobacterium leprae]
2285	38861095 (553, 554)	Novel Protein sim. GBank gi|728646|emb|CAA88514| - (Z48613) unknown		UNCLASSIFIED	1024
		[Saccharomyces cerevisiae]
2286	86690662 (8805, 8806)	Novel Protein sim. GBank gi|728831|sp|P39188|ALU1_HUMAN - !!!! ALU		UNCLASSIFIED	1023
		SUBFAMILY J WARNING ENTRY !!!!
2287	57458406 (5613, 5614)	Novel Protein sim. GBank gi|728835|sp|P39192|ALU5_HUMAN - !!!! ALU		UNCLASSIFIED	1051
		SUBFAMILY SC WARNING ENTRY !!!!
2288	65452389 (2579, 2580)	Novel Protein sim. GBank gi|728836|sp|P39193|ALU6_HUMAN - !!!! ALU		UNCLASSIFIED	1014
		SUBFAMILY SP WARNING ENTRY !!!!
2289	66372202 (5051, 5052)	Novel Protein sim. GBank gi|728836|sp|P39193|ALU6_HUMAN - !!!! ALU		UNCLASSIFIED	1022
		SUBFAMILY SP WARNING ENTRY !!!!
2290	78938732 (2811, 2812)	Novel Protein sim. GBank gi|728837|sp|P39194|ALU7_HUMAN - !!!! ALU		UNCLASSIFIED	1041
		SUBFAMILY SQ WARNING ENTRY !!!!
2291	55176697 (3701, 3702)	Novel Protein sim. GBank gi|729432|sp|P22140|EPT1_YEAST -		UNCLASSIFIED	1006
		ETHANOLAMINEPHOSPHOTRANSFERASE (ETHPT)
2292	28821449 (2599, 2600)	Novel Protein sim. GBank gi|729999|sp|Q01159|MCE1_YEAST - MRNA		UNCLASSIFIED	1006
		CAPPING ENZYME (MRNA GUANYLYLTRANSFERASE) (GTP-RNA
		GUANYLYLTRANSFERASE)
2293	79415423 (6293, 6294)	Novel Protein sim. GBank gi|730269|sp|P32521|PAN1_YEAST - PAN1		UNCLASSIFIED	1004
		PROTEIN
2294	29688622 (235, 236)	Novel Protein sim. GBank gi|730428|sp|P40607|PURA_VIBPA -		UNCLASSIFIED	1014
		ADENYLOSUCCINATE SYNTHETASE (IMP-ASPARTATE LIGASE)
2295	5961411 (7299, 7300)	Novel Protein sim. GBank gi|730742|sp|P38717|SIP3_YEAST - SIP3		UNCLASSIFIED	1055
		PROTEIN
2296	9383506 (79, 80)	Novel Protein sim. GBank gi|731087|sp|P20703|UVSW_BPT4 - UVSW		UNCLASSIFIED	1015
		PROTEIN (DAR PROTEIN)
2297	80021661 (1895, 1896)	Novel Protein sim. GBank gi|731302|sp|P27637|YAI4_YEAST -		UNCLASSIFIED	1003
		HYPOTHETICAL 78.3 KD PROTEIN IN SEN34-ADE1 INTERGENIC
		REGION
2298	20637641 (3195, 3196)	Novel Protein sim. GBank gi|731404|sp|P39996|YEB7_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 38.2 KD PROTEIN IN PMP2-VAC8 INTERGENIC
		REGION
2299	79235255 (3927, 3928)	Novel Protein sim. GBank gi|731408|sp|P39993|YEC2_YEAST -		UNCLASSIFIED	1006, 1024
		HYPOTHETICAL 165.7 KD PROTEIN IN RIP1-URA3 INTERGENIC
		REGION
2300	78386371 (7417, 7418)	Novel Protein sim. GBank gi|731417|sp|P39985|YEG5_YEAST -		UNCLASSIFIED	1024
		HYPOTHETICAL 115.9 KD PROTEIN IN HAT2-RPL15B INTERGENIC
		REGION
2301	79619700 (4849, 4850)	Novel Protein sim. GBank gi|731434|sp|P40008|YEJ4_YEAST -		UNCLASSIFIED	1015, 1023, 1024
		HYPOTHETICAL 25.1 KD PROTEIN IN PMI40-PAC2 INTERGENIC
		REGION
2302	80029280 (8015, 8016)	Novel Protein sim. GBank gi|731441|sp|P40013|BIM1_YEAST - BIM1		UNCLASSIFIED	1015, 1020, 1031, 1041
		PROTEIN
2303	79239198 (3941, 3942)	Novel Protein sim. GBank gi|731445|sp|P40017|YEL4_YEAST -		UNCLASSIFIED	1002, 1015, 1020, 1021
		HYPOTHETICAL 103.3 KD PROTEIN IN PRO3-GCD11 INTERGENIC
		REGION
2304	81712653 (6439, 6440)	Novel Protein sim. GBank gi|731516|sp|P40082|YEW5_YEAST -		UNCLASSIFIED	1002, 1003, 1004, 1006,
		HYPOTHETICAL 15.4 KD PROTEIN IN GLC7-GDI1 INTERGENIC			1007, 1008, 1020, 1022,
		REGION			1024, 1025, 1041, 1051
2305	78901055 (6311, 6312)	Novel Protein sim. GBank gi|731584|sp|P38898|YH17_YEAST -		UNCLASSIFIED	1036
		HYPOTHETICAL 17.1 KD PROTEIN IN PUR5 3′REGION
2306	79439568 (7937, 7938)	Novel Protein sim. GBank gi|731584|sp|P38898|YH17_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 17.1 KD PROTEIN IN PUR5 3′REGION
2307	80215989 (8101, 8102)	Novel Protein sim. GBank gi|731584|sp|P38898|YH17_YEAST -		UNCLASSIFIED	1002, 1003, 1006, 1007,
		HYPOTHETICAL 17.1 KD PROTEIN IN PUR5 3′REGION			1008, 1020, 1022, 1025,
					1031, 1035, 1036, 1041
2308	94292375 (213, 214)	Novel Protein sim. GBank gi|731679|sp|P38800|YHO0_YEAST -		UNCLASSIFIED	1002
		HYPOTHETICAL 149.7 KD PROTEIN IN IRE1-KSP1 INTERGENIC
		REGION
2309	8504873 (7399, 7400)	Novel Protein sim. GBank gi|731679|sp|P38800|YHO0_YEAST -		UNCLASSIFIED	1022
		HYPOTHETICAL 149.7 KD PROTEIN IN IRE1-KSP1 INTERGENIC
		REGION
2310	78970331 (2015, 2016)	Novel Protein sim. GBank gi|731701|sp|P38821|YHR3_YEAST -		UNCLASSIFIED	1006
		HYPOTHETICAL 54.2 KD PROTEIN IN ERP5-ORC6 INTERGENIC
		REGION
2311	82074896 (1059, 1060)	Novel Protein sim. GBank gi|731758|sp|P38875|YHY8_YEAST -		UNCLASSIFIED	1002, 1004, 1006, 1007,
		HYPOTHETICAL 67.8 KD PROTEIN IN IKI1-ERG9 INTERGENIC			1008, 1014, 1015, 1020,
		REGION			1021, 1022, 1023, 1025,
					1031, 1041
2312	78713647 (8707, 8708)	Novel Protein sim. GBank gi|731784|sp|P40547|YIB7_YEAST -		UNCLASSIFIED	1002
		HYPOTHETICAL 105.5 KD PROTEIN IN RPL5A-BAR1 INTERGENIC
		REGION
2313	81339427 (7543, 7544)	Novel Protein sim. GBank gi|731790|sp|P40542|YIC5_YEAST -		UNCLASSIFIED	1004, 1007, 1010, 1015,
		HYPOTHETICAL 14.1 KD PROTEIN IN IRR1-TIM44 INTERGENIC			1020, 1021, 1022, 1031,
		REGION			1035, 1051
2314	79619706 (5249, 5250)	Novel Protein sim. GBank gi|731879|sp|P40461|YIO1_YEAST -		UNCLASSIFIED	1023
		HYPOTHETICAL 14.4 KD PROTEIN IN CCT2-AXL2 INTERGENIC
		REGION
2315	57298970 (5963, 5964)	Novel Protein sim. GBank gi|731888|sp|P40450|YIP9_YEAST -		UNCLASSIFIED	1020, 1022
		HYPOTHETICAL 156.9 KD PROTEIN IN FOX3-UBP7 INTERGENIC
		REGION
2316	80075552 (1375, 1376)	Novel Protein sim. GBank gi|731920|sp|P40577|YIU5_YEAST -		UNCLASSIFIED	1002, 1004, 1006, 1015,
		HYPOTHETICAL 42.8 KD PROTEIN IN DAL81-YVH1 INTERGENIC			1020, 1036, 1041
		REGION
2317	80502238 (1579, 1580)	Novel Protein sim. GBank gi|732198|sp|P40168|YNT5_YEAST -		UNCLASSIFIED	1001, 1002, 1008, 1010,
		HYPOTHETICAL 26.5 KD PROTEIN IN WHI3-CHS1 INTERGENIC			1020, 1021, 1025
		REGION
2318	79858444 (3581, 3582)	Novel Protein sim. GBank gi|732331|sp|P39584|YWBA_BACSU -		UNCLASSIFIED	1036
		HYPOTHETICAL 47.6 KD PROTEIN IN EPR-GALK INTERGENIC
		REGION
2319	80059821 (7407, 7408)	Novel Protein sim. GBank gi|80631|pir||JS0053 - hypothetical 13.7 K		UNCLASSIFIED	1006, 1022, 1024
		protein - Mycobacterium fortuitum plasmid pAL5000
2320	78388279 (1889, 1890)	Novel Protein sim. GBank gi|81286|pir||S22697 - extensin - Volvox carteri		UNCLASSIFIED	1024
		(fragment)
2321	79442416 (2463, 2464)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1020
		[Human herpesvirus 6]
2322	21145976 (2919, 2920)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1031
		[Human herpesvirus 6]
2323	57281574 (3253, 3254)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1031
		[Human herpesvirus 6]
2324	11614956 (3609, 3610)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1020
		[Human herpesvirus 6]
2325	80085347 (6203, 6204)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1051
		[Human herpesvirus 6]
2326	78679959 (6219, 6220)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1015
		[Human herpesvirus 6]
2327	11695659 (6857, 6858)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1031
		[Human herpesvirus 6]
2328	66053496 (7265, 7266)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1008
		[Human herpesvirus 6]
2329	19904337 (7541, 7542)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1022
		[Human herpesvirus 6]
2330	20449755 (7849, 7850)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1008
		[Human herpesvirus 6]
2331	19899239 (8111, 8112)	Novel Protein sim. GBank gi|854065|emb|CAA58337| - (X83413) U88		UNCLASSIFIED	1022
		[Human herpesvirus 6]
2332	86459081 (4421, 4422)	Novel Protein sim. GBank gi|894178 (U18919) - unknown [Homo sapiens]		UNCLASSIFIED	1008, 1031
2333	70445515(4725, 4726)	Novel Protein sim. GBank gi|924282 (U12767) - mitogen induced nuclear		UNCLASSIFIED	1017, 1038
		orphan receptor [Homo sapiens]
2334	14997852 (2277, 2278)	Novel Protein sim. GBank gi|93504|pir||D34768 - ORF4 protein - Orf virus		UNCLASSIFIED	1001, 1002
		(strain NZ2)
2335	78939072 (5, 6)			UNCLASSIFIED	1021
2336	94146943 (9, 10)			UNCLASSIFIED	1002
2337	10867509 (21, 22)			UNCLASSIFIED	1031
2338	29442779 (63, 64)			UNCLASSIFIED	1020
2339	52384145 (69, 70)			UNCLASSIFIED	1033
2340	80235743 (75, 76)			UNCLASSIFIED	1000, 1020, 1026
2341	79954971 (81, 82)			UNCLASSIFIED	1001
2342	78378519 (97, 98)			UNCLASSIFIED	1024, 1051
2343	79560276 (103, 104)			UNCLASSIFIED	1035
2344	21435078 (121, 122)			UNCLASSIFIED	1031
2345	32086152 (147, 148)			UNCLASSIFIED	1041
2346	80310105 (161, 162)			UNCLASSIFIED	1004, 1008, 1020, 1021,
					1026, 1031
2347	10368084 (167, 168)			UNCLASSIFIED	1006
2348	46806994 (181, 182)			UNCLASSIFIED	1038
2349	29695963 (187, 188)			UNCLASSIFIED	1022
2350	78283646 (191, 192)			UNCLASSIFIED	1026
2351	52561322 (195, 196)			UNCLASSIFIED	1002
2352	80023954 (203, 204)			UNCLASSIFIED	1050
2353	21437085 (205, 206)			UNCLASSIFIED	1020, 1055
2354	79621320 (207, 208)			UNCLASSIFIED	1003
2355	86687539 (209, 210)			UNCLASSIFIED	1005
2356	78735185 (223, 224)			UNCLASSIFIED	1015, 1020
2357	66407901 (237, 238)			UNCLASSIFIED	1022
2358	35049780 (245, 246)			UNCLASSIFIED	1027
2359	66138496 (261, 262)			UNCLASSIFIED	1003
2360	78734108 (263, 264)			UNCLASSIFIED	1027
2361	91230317 (269, 270)			UNCLASSIFIED	1018, 1035
2362	13025189 (283, 284)			UNCLASSIFIED	1028
2363	12745521 (291, 292)			UNCLASSIFIED	1028
2364	20438376 (327, 328)			UNCLASSIFIED	1008
2365	10075364 (353, 354)			UNCLASSIFIED	1015
2366	56172002 (365, 366)			UNCLASSIFIED	1043
2367	80502101 (369, 370)			UNCLASSIFIED	1010
2368	27847542 (393, 394)			UNCLASSIFIED	1020
2369	78747281 (409, 410)			UNCLASSIFIED	1020
2370	32311509 (417, 418)			UNCLASSIFIED	1026
2371	38906497 (419, 420)			UNCLASSIFIED	1024
2372	91237422 (423, 424)			UNCLASSIFIED	1006, 1008, 1022, 1023,
					1031, 1041
2373	79163357 (439, 440)			UNCLASSIFIED	1028
2374	20731608 (461, 462)			UNCLASSIFIED	1031
2375	94843553 (467, 468)			UNCLASSIFIED	1041
2376	30536390 (477, 478)			UNCLASSIFIED	1024
2377	57051524 (479, 480)			UNCLASSIFIED	1046
2378	43336130 (487, 488)			UNCLASSIFIED	1000
2379	79612139 (489, 490)			UNCLASSIFIED	1004
2380	11813963 (499, 500)			UNCLASSIFIED	1003
2381	65686807 (507, 508)			UNCLASSIFIED	1008, 1021
2382	80054347 (511, 512)			UNCLASSIFIED	1008
2383	99412314 (523, 524)			UNCLASSIFIED	1020, 1034
2384	77600695 (527, 528)			UNCLASSIFIED	1046
2385	65487838 (529, 530)			UNCLASSIFIED	1021
2386	29021183 (531, 532)			UNCLASSIFIED	1002
2387	95103944 (533, 534)			UNCLASSIFIED	1002, 1033, 1038
2388	33763765 (539, 540)			UNCLASSIFIED	1024
2389	6831423 (543, 544)			UNCLASSIFIED	1020
2390	38399460 (547, 548)			UNCLASSIFIED	1024
2391	29442480 (569, 570)			UNCLASSIFIED	1051
2392	16342187 (593, 594)			UNCLASSIFIED	1020
2393	54540457 (605, 606)			UNCLASSIFIED	1038
2394	36623048 (633, 634)			UNCLASSIFIED	1031
2395	91236768 (637, 638)			UNCLASSIFIED	1014, 1042
2396	9893819 (673, 674)			UNCLASSIFIED	1036
2397	11091334 (701, 702)			UNCLASSIFIED	1020, 1050
2398	79863683 (705, 706)			UNCLASSIFIED	1010
2399	52432672 (735, 736)			UNCLASSIFIED	1026
2400	20608055 (753, 754)			UNCLASSIFIED	1020
2401	46729292 (757, 758)			UNCLASSIFIED	1017
2402	78835499 (763, 764)			UNCLASSIFIED	1007
2403	78968380 (771, 772)			UNCLASSIFIED	1014, 1051
2404	19436353 (773, 774)			UNCLASSIFIED	1041
2405	28979370 (797, 798)			UNCLASSIFIED	1007
2406	81883785 (801, 802)			UNCLASSIFIED	1020, 1050, 1051
2407	19887611 (815, 816)			UNCLASSIFIED	1031
2408	50672706 (817, 818)			UNCLASSIFIED	1033
2409	11692942 (831, 832)			UNCLASSIFIED	1004
2410	86477740 (847, 848)			UNCLASSIFIED	1017
2411	47660207 (857, 858)			UNCLASSIFIED	1026
2412	71808275 (871, 872)			UNCLASSIFIED	1019, 1035, 1041
2413	65881024 (873, 874)			UNCLASSIFIED	1051
2414	79631806 (881, 882)			UNCLASSIFIED	1036
2415	95413187 (897, 898)			UNCLASSIFIED	1020, 1040
2416	39724529 (907, 908)			UNCLASSIFIED	1024
2417	23308591 (909, 910)			UNCLASSIFIED	1050
2418	23308860 (917, 918)			UNCLASSIFIED	1050
2419	78963308 (923, 924)			UNCLASSIFIED	1051
2420	90991725 (927, 928)			UNCLASSIFIED	1018
2421	80187255 (929, 930)			UNCLASSIFIED	1020, 1055
2422	9667021 (937, 938)			UNCLASSIFIED	1036
2423	78380341 (963, 964)			UNCLASSIFIED	1006
2424	81941215 (983, 984)			UNCLASSIFIED	1004, 1010, 1014, 1015
2425	20721514 (1003, 1004)			UNCLASSIFIED	1004
2426	94143077 (1007, 1008)			UNCLASSIFIED	1041
2427	91228835 (1021, 1022)			UNCLASSIFIED	1002
2428	51237185 (1033, 1034)			UNCLASSIFIED	1033
2429	80178026 (1035, 1036)			UNCLASSIFIED	1017, 1020, 1022, 1024,
					1034
2430	55775842 (1047, 1048)			UNCLASSIFIED	1039
2431	25143318 (1055, 1056)			UNCLASSIFIED	1002, 1015
2432	78982582 (1057, 1058)			UNCLASSIFIED	1014
2433	46849648 (1079, 1080)			UNCLASSIFIED	1026
2434	30393478 (1089, 1090)			UNCLASSIFIED	1027
2435	55925156 (1109, 1110)			UNCLASSIFIED	1019
2436	78899041 (1115, 1116)			UNCLASSIFIED	1021, 1036
2437	10846436 (1121, 1122)			UNCLASSIFIED	1015
2438	29019179 (1123, 1124)			UNCLASSIFIED	1006
2439	78186436 (1133, 1134)			UNCLASSIFIED	1020, 1053
2440	20294837 (1141, 1142)			UNCLASSIFIED	1031
2441	12926066 (1143, 1144)			UNCLASSIFIED	1022
2442	80503910 (1145, 1146)			UNCLASSIFIED	1010
2443	23297653 (1167, 1168)			UNCLASSIFIED	1021
2444	80090387 (1177, 1178)			UNCLASSIFIED	1031
2445	71095137 (1183, 1184)			UNCLASSIFIED	1026, 1050
2446	55278308 (1187, 1188)			UNCLASSIFIED	1051
2447	77673620 (1191, 1192)			UNCLASSIFIED	1002
2448	79201268 (1193, 1194)			UNCLASSIFIED	1002, 1041, 1051
2449	54531954 (1197, 1198)			UNCLASSIFIED	1038
2450	55310202 (1199, 1200)			UNCLASSIFIED	1039
2451	55930627 (1211, 1212)			UNCLASSIFIED	1038, 1039
2452	79843141 (1225, 1226)			UNCLASSIFIED	1041
2453	54858768 (1231, 1232)			UNCLASSIFIED	1017
2454	29001471 (1239, 1240)			UNCLASSIFIED	1041
2455	78277043 (1249, 1250)			UNCLASSIFIED	1026
2456	16835059 (1251, 1252)			UNCLASSIFIED	1021
2457	65327575 (1275, 1276)			UNCLASSIFIED	1020
2458	87114368 (1279, 1280)			UNCLASSIFIED	1023
2459	29017861 (1283, 1284)			UNCLASSIFIED	1041
2460	10360425 (1289, 1290)			UNCLASSIFIED	1015
2461	17937488 (1299, 1300)			UNCLASSIFIED	1006
2462	13033655 (1325, 1326)			UNCLASSIFIED	1028
2463	39723162 (1327, 1328)			UNCLASSIFIED	1034
2464	78527689 (1333, 1334)			UNCLASSIFIED	1002
2465	86476709 (1341, 1342)			UNCLASSIFIED	1026
2466	91238781 (1347, 1348)			UNCLASSIFIED	1002
2467	32568841 (1351, 1352)			UNCLASSIFIED	1031
2468	46886543 (1377, 1378)			UNCLASSIFIED	1034
2469	65694982 (1387, 1388)			UNCLASSIFIED	1035
2470	65892801 (1405, 1406)			UNCLASSIFIED	1051
2471	47660384 (1407, 1408)			UNCLASSIFIED	1026
2472	79816169 (1415, 1416)			UNCLASSIFIED	1003, 1004
2473	80414675 (1425, 1426)			UNCLASSIFIED	1004, 1023, 1051
2474	79834138 (1431, 1432)			UNCLASSIFIED	1006
2475	87914057 (1451, 1452)			UNCLASSIFIED	1013
2476	11383791 (1455, 1456)			UNCLASSIFIED	1014
2477	80501670 (1459, 1460)			UNCLASSIFIED	1010
2478	57057036 (1465, 1466)			UNCLASSIFIED	1051
2479	78464930 (1473, 1474)			UNCLASSIFIED	1006, 1015
2480	78994822 (1475, 1476)			UNCLASSIFIED	1002
2481	77797639 (1481, 1482)			UNCLASSIFIED	1048
2482	34269843 (1483, 1484)			UNCLASSIFIED	1024
2483	5729122 (1491, 1492)			UNCLASSIFIED	1055
2484	78916225 (1497, 1498)			UNCLASSIFIED	1007, 1024, 1036
2485	33763311 (1499, 1500)			UNCLASSIFIED	1024
2486	11801030 (1521, 1522)			UNCLASSIFIED	1028
2487	78913158 (1523, 1524)			UNCLASSIFIED	1041
2488	46671302 (1533, 1534)			UNCLASSIFIED	1020, 1024
2489	30670018 (1545, 1546)			UNCLASSIFIED	1024
2490	46763776 (1553, 1554)			UNCLASSIFIED	1038
2491	48029783 (1569, 1570)			UNCLASSIFIED	1037
2492	8018632 (1577, 1578)			UNCLASSIFIED	1020
2493	30661464 (1583, 1584)			UNCLASSIFIED	1020
2494	11394815 (1593, 1594)			UNCLASSIFIED	1020
2495	27974956 (1599, 1600)			UNCLASSIFIED	1020
2496	79250367 (1601, 1602)			UNCLASSIFIED	1006, 1014, 1021, 1035,
					1041
2497	27261690 (1607, 1608)			UNCLASSIFIED	1041
2498	80479789 (1619, 1620)			UNCLASSIFIED	1010
2499	32444163 (1627, 1628)			UNCLASSIFIED	1026
2500	80202957 (1629, 1630)			UNCLASSIFIED	1014
2501	33182220 (1637, 1638)			UNCLASSIFIED	1024
2502	5625873 (1641, 1642)			UNCLASSIFIED	1055
2503	94852905 (1647, 1648)			UNCLASSIFIED	1041
2504	65671892 (1651, 1652)			UNCLASSIFIED	1014
2505	20703567 (1653, 1654)			UNCLASSIFIED	1008, 1022
2506	20615832 (1659, 1660)			UNCLASSIFIED	1004
2507	16835986 (1675, 1676)			UNCLASSIFIED	1036
2508	65672070 (1695, 1696)			UNCLASSIFIED	1014
2509	65884029 (1731, 1732)			UNCLASSIFIED	1035
2510	78471966 (1759, 1760)			UNCLASSIFIED	1024
2511	78676775 (1763, 1764)			UNCLASSIFIED	1006
2512	78029354 (1773, 1774)			UNCLASSIFIED	1024
2513	25256400 (1779, 1780)			UNCLASSIFIED	1006
2514	91012600 (1781, 1782)			UNCLASSIFIED	1002
2515	49300541 (1783, 1784)			UNCLASSIFIED	1033
2516	13085578 (1797, 1798)			UNCLASSIFIED	1025
2517	79401347 (1799, 1800)			UNCLASSIFIED	1004
2518	14996212 (1811, 1812)			UNCLASSIFIED	1022
2519	78914607 (1823, 1824)			UNCLASSIFIED	1036
2520	79551154 (1839, 1840)			UNCLASSIFIED	1001
2521	16839667 (1843, 1844)			UNCLASSIFIED	1021
2522	78395601 (1847, 1848)			UNCLASSIFIED	1027
2523	90935673 (1857, 1858)			UNCLASSIFIED	1023
2524	57045809 (1859, 1860)			UNCLASSIFIED	1039
2525	80067536 (1865, 1866)			UNCLASSIFIED	1020, 1021, 1051, 1055
2526	79462581 (1883, 1884)			UNCLASSIFIED	1031
2527	80082630 (1901, 1902)			UNCLASSIFIED	1020, 1031
2528	77894253 (1921, 1922)			UNCLASSIFIED	1033
2529	11795564 (1925, 1926)			UNCLASSIFIED	1035
2530	80173534 (1945, 1946)			UNCLASSIFIED	1020, 1038
2531	48030251 (1971, 1972)			UNCLASSIFIED	1037
2532	98182977 (1973, 1974)			UNCLASSIFIED	1019, 1035, 1055
2533	80502690 (1983, 1984)			UNCLASSIFIED	1010
2534	6352882 (1989, 1990)			UNCLASSIFIED	1055
2535	87454586 (1991, 1992)			UNCLASSIFIED	1023
2536	23292502 (1993, 1994)			UNCLASSIFIED	1036
2537	86679840 (2001, 2002)			UNCLASSIFIED	1001, 1005
2538	94630813 (2003, 2004)			UNCLASSIFIED	1036
2539	10051016 (2013, 2014)			UNCLASSIFIED	1041
2540	33267917 (2037, 2038)			UNCLASSIFIED	1001, 1047
2541	80081934 (2039, 2040)			UNCLASSIFIED	1020, 1041
2542	65691929 (2073, 2074)			UNCLASSIFIED	1007
2543	20709450 (2081, 2082)			UNCLASSIFIED	1003, 1004
2544	39735124 (2083, 2084)			UNCLASSIFIED	1038
2545	79918033 (2087, 2088)			UNCLASSIFIED	1015
2546	29213655 (2091, 2092)			UNCLASSIFIED	1041
2547	55505821 (2097, 2098)			UNCLASSIFIED	1019
2548	85817553 (2103, 2104)			UNCLASSIFIED	1004, 1017, 1028, 1031,
					1041
2549	13517048 (2109, 2110)			UNCLASSIFIED	1022
2550	78734081 (2113, 2114)			UNCLASSIFIED	1024, 1051
2551	30486972 (2117, 2118)			UNCLASSIFIED	1035
2552	46850156 (2137, 2138)			UNCLASSIFIED	1026
2553	20295911 (2161, 2162)			UNCLASSIFIED	1020
2554	15021067 (2165, 2166)			UNCLASSIFIED	1001
2555	78676881 (2167, 2168)			UNCLASSIFIED	1015
2556	65484134 (2169, 2170)			UNCLASSIFIED	1022, 1051
2557	46571876 (2177, 2178)			UNCLASSIFIED	1026
2558	94253210 (2179, 2180)			UNCLASSIFIED	1036
2559	79416080 (2189, 2190)			UNCLASSIFIED	1020, 1022
2560	30660716 (2191, 2192)			UNCLASSIFIED	1006
2561	29268810 (2199, 2200)			UNCLASSIFIED	1020
2562	10302433 (2221, 2222)			UNCLASSIFIED	1035
2563	12970626 (2225, 2226)			UNCLASSIFIED	1022
2564	81646720 (2239, 2240)			UNCLASSIFIED	1022, 1023, 1026, 1051
2565	17135118 (2247, 2248)			UNCLASSIFIED	1021
2566	94233323 (2249, 2250)			UNCLASSIFIED	1002
2567	55403753 (2251, 2252)			UNCLASSIFIED	1017
2568	78043426 (2259, 2260)			UNCLASSIFIED	1022
2569	16494096 (2269, 2270)			UNCLASSIFIED	1006
2570	15022168 (2293, 2294)			UNCLASSIFIED	1051
2571	16792287 (2297, 2298)			UNCLASSIFIED	1036
2572	10261836 (2301, 2302)			UNCLASSIFIED	1021
2573	78461311 (2311, 2312)			UNCLASSIFIED	1024
2574	29352425 (2347, 2348)			UNCLASSIFIED	1007
2575	79970354 (2357, 2358)			UNCLASSIFIED	1002
2576	11813647 (2365, 2366)			UNCLASSIFIED	1003
2577	20752448 (2387, 2388)			UNCLASSIFIED	1020
2578	77530463 (2399, 2400)			UNCLASSIFIED	1035
2579	52256467 (2419, 2420)			UNCLASSIFIED	1033
2580	78729050 (2439, 2440)			UNCLASSIFIED	1006
2581	71092329 (2451, 2452)			UNCLASSIFIED	1026, 1050
2582	20294841 (2467, 2468)			UNCLASSIFIED	1031
2583	66314057 (2469, 2470)			UNCLASSIFIED	1051
2584	83074239 (2481, 2482)			UNCLASSIFIED	1050
2585	13519288 (2489, 2490)			UNCLASSIFIED	1022
2586	10132589 (2491, 2492)			UNCLASSIFIED	1023
2587	79468481 (2503, 2504)			UNCLASSIFIED	1014
2588	80404939 (2505, 2506)			UNCLASSIFIED	1015, 1023, 1026
2589	65480474 (2507, 2508)			UNCLASSIFIED	1035, 1051
2590	78285849 (2513, 2514)			UNCLASSIFIED	1000
2591	78799479 (2517, 2518)			UNCLASSIFIED	1024
2592	79160595 (2525, 2526)			UNCLASSIFIED	1003
2593	35010285 (2531, 2532)			UNCLASSIFIED	1031
2594	11689777 (2535, 2536)			UNCLASSIFIED	1031
2595	78506537 (2539, 2540)			UNCLASSIFIED	1027, 1051
2596	46571860 (2541, 2542)			UNCLASSIFIED	1026
2597	36512560 (2547, 2548)			UNCLASSIFIED	1024
2598	78796333 (2549, 2550)			UNCLASSIFIED	1024
2599	6783257 (2551, 2552)			UNCLASSIFIED	1020
2600	70972815 (2557, 2558)			UNCLASSIFIED	1033, 1034, 1037, 1038,
					1039
2601	78165237 (2561, 2562)			UNCLASSIFIED	1027
2602	78945363 (2569, 2570)			UNCLASSIFIED	1027
2603	28991341 (2581, 2582)			UNCLASSIFIED	1021
2604	78259411 (2587, 2588)			UNCLASSIFIED	1024
2605	29916216 (2601, 2602)			UNCLASSIFIED	1027
2606	80051011 (2605, 2606)			UNCLASSIFIED	1003
2607	13051740 (2607, 2608)			UNCLASSIFIED	1025
2608	94315437 (2619, 2620)			UNCLASSIFIED	1002
2609	10025445 (2621, 2622)			UNCLASSIFIED	1038
2610	80231386 (2627, 2628)			UNCLASSIFIED	1020
2611	78956209 (2639, 2640)			UNCLASSIFIED	1006
2612	25334976 (2641, 2642)			UNCLASSIFIED	1036
2613	95294554 (2659, 2660)			UNCLASSIFIED	1004, 1008
2614	32297941 (2661, 2662)			UNCLASSIFIED	1000
2615	79628613 (2695, 2696)			UNCLASSIFIED	1001, 1020, 1024, 1051
2616	80084693 (2709, 2710)			UNCLASSIFIED	1051
2617	17296168 (2733, 2734)			UNCLASSIFIED	1006
2618	57037459 (2737, 2738)			UNCLASSIFIED	1010, 1026, 1028, 1050
2619	79475353 (2741, 2742)			UNCLASSIFIED	1020
2620	91237580 (2753, 2754)			UNCLASSIFIED	1008
2621	13519703 (2763, 2764)			UNCLASSIFIED	1022
2622	5843274 (2779, 2780)			UNCLASSIFIED	1055
2623	79611573 (2781, 2782)			UNCLASSIFIED	1004
2624	11777012 (2785, 2786)			UNCLASSIFIED	1004
2625	20295915 (2791, 2792)			UNCLASSIFIED	1020
2626	78393562 (2799, 2800)			UNCLASSIFIED	1027, 1041
2627	20296449 (2843, 2844)			UNCLASSIFIED	1031
2628	80249573 (2853, 2854)			UNCLASSIFIED	1003, 1004, 1028, 1041
2629	79585883 (2855, 2856)			UNCLASSIFIED	1051
2630	79200992 (2857, 2858)			UNCLASSIFIED	1022
2631	16540873 (2867, 2868)			UNCLASSIFIED	1036
2632	79193127 (2871, 2872)			UNCLASSIFIED	1022
2633	11808824 (2887, 2888)			UNCLASSIFIED	1020
2634	79764857 (2891, 2892)			UNCLASSIFIED	1006
2635	27367480 (2915, 2916)			UNCLASSIFIED	1020
2636	87459608 (2931, 2932)			UNCLASSIFIED	1013
2637	79871671 (2937, 2938)			UNCLASSIFIED	1027, 1037, 1041, 1051
2638	79599325 (2941, 2942)			UNCLASSIFIED	1002, 1006
2639	10314889 (2957, 2958)			UNCLASSIFIED	1035
2640	79826242 (2959, 2960)			UNCLASSIFIED	1041
2641	46899813 (2977, 2978)			UNCLASSIFIED	1037
2642	94132451 (2987, 2988)			UNCLASSIFIED	1002
2643	47651933 (2993, 2994)			UNCLASSIFIED	1026
2644	85516772 (2995, 2996)			UNCLASSIFIED	1050
2645	30230323 (2997, 2998)			UNCLASSIFIED	1024
2646	30793733 (3005, 3006)			UNCLASSIFIED	1024
2647	80056153 (3019, 3020)			UNCLASSIFIED	1002, 1020
2648	78787501 (3027, 3028)			UNCLASSIFIED	1006, 1007, 1020
2649	79181749 (3029, 3030)			UNCLASSIFIED	1015, 1025
2650	65886563 (3035, 3036)			UNCLASSIFIED	1014
2651	50677267 (3039, 3040)			UNCLASSIFIED	1033
2652	78898639 (3073, 3074)			UNCLASSIFIED	1002, 1015
2653	16838936 (3075, 3076)			UNCLASSIFIED	1036
2654	16549137 (3079, 3080)			UNCLASSIFIED	1035
2655	16709708 (3081, 3082)			UNCLASSIFIED	1036
2656	27823588 (3085, 3086)			UNCLASSIFIED	1008
2657	13506489 (3095, 3096)			UNCLASSIFIED	1031
2658	46852790 (3097, 3098)			UNCLASSIFIED	1051
2659	86466913 (3099, 3100)			UNCLASSIFIED	1026
2660	30253082 (3113, 3114)			UNCLASSIFIED	1027
2661	77685125 (3117, 3118)			UNCLASSIFIED	1005
2662	10127591 (3131, 3132)			UNCLASSIFIED	1001
2663	51975910 (3153, 3154)			UNCLASSIFIED	1017
2664	56065523 (3209, 3210)			UNCLASSIFIED	1019
2665	35006356 (3213, 3214)			UNCLASSIFIED	1047
2666	80503920 (3235, 3236)			UNCLASSIFIED	1010
2667	46853933 (3237, 3238)			UNCLASSIFIED	1026
2668	17121495 (3249, 3250)			UNCLASSIFIED	1027
2669	19726688 (3267, 3268)			UNCLASSIFIED	1035
2670	65687035 (3273, 3274)			UNCLASSIFIED	1038
2671	80475471 (3277, 3278)			UNCLASSIFIED	1006, 1007, 1008, 1010,
					1015, 1020, 1022, 1023,
					1041
2672	70952517 (3287, 3288)			UNCLASSIFIED	1034
2673	30783130 (3295, 3296)			UNCLASSIFIED	1007
2674	99407738 (3313, 3314)			UNCLASSIFIED	1021, 1031, 1034, 1048
2675	20431922 (3321, 3322)			UNCLASSIFIED	1008
2676	10173821 (3327, 3328)			UNCLASSIFIED	1003
2677	78180052 (3351, 3352)			UNCLASSIFIED	1022
2678	23290719 (3355, 3356)			UNCLASSIFIED	1015
2679	79574506 (3359, 3360)			UNCLASSIFIED	1028
2680	47656347 (3365, 3366)			UNCLASSIFIED	1026
2681	68137709 (3373, 3374)			UNCLASSIFIED	1002
2682	39559794 (3381, 3382)			UNCLASSIFIED	1001
2683	10344736 (3389, 3390)			UNCLASSIFIED	1035
2684	78968773 (3399, 3400)			UNCLASSIFIED	1035, 1051
2685	94238051 (3413, 3414)			UNCLASSIFIED	1051
2686	79458087 (3417, 3418)			UNCLASSIFIED	1014, 1028
2687	38211918 (3425, 3426)			UNCLASSIFIED	1031
2688	33763565 (3433, 3434)			UNCLASSIFIED	1024
2689	33188865 (3435, 3436)			UNCLASSIFIED	1024
2690	20287670 (3439, 3440)			UNCLASSIFIED	1031
2691	80457783 (3441, 3442)			UNCLASSIFIED	1035
2692	78733339 (3453, 3454)			UNCLASSIFIED	1027
2693	13083260 (3473, 3474)			UNCLASSIFIED	1028
2694	86465105 (3479, 3480)			UNCLASSIFIED	1026
2695	38910894 (3481, 3482)			UNCLASSIFIED	1022
2696	27842729 (3491, 3492)			UNCLASSIFIED	1020, 1031
2697	79161229 (3501, 3502)			UNCLASSIFIED	1001, 1003, 1022
2698	78046030 (3513, 3514)			UNCLASSIFIED	1022
2699	65470706 (3527, 3528)			UNCLASSIFIED	1046
2700	41086447 (3537, 3538)			UNCLASSIFIED	1034
2701	20473522 (3539, 3540)			UNCLASSIFIED	1020
2702	27990991 (3549, 3550)			UNCLASSIFIED	1014
2703	79551903 (3563, 3564)			UNCLASSIFIED	1035
2704	24129331 (3565, 3566)			UNCLASSIFIED	1002
2705	56073877 (3573, 3574)			UNCLASSIFIED	1019
2706	10841539 (3579, 3580)			UNCLASSIFIED	1021
2707	94662837 (3587, 3588)			UNCLASSIFIED	1022
2708	80050593 (3591, 3592)			UNCLASSIFIED	1031
2709	16467038 (3599, 3600)			UNCLASSIFIED	1002
2710	79456231 (3605, 3606)			UNCLASSIFIED	1004
2711	25263385 (3607, 3608)			UNCLASSIFIED	1006
2712	80429688 (3613, 3614)			UNCLASSIFIED	1004, 1007, 1008, 1020,
					1022, 1031, 1035, 1041
2713	79167751 (3631, 3632)			UNCLASSIFIED	1004
2714	20385910 (3643, 3644)			UNCLASSIFIED	1003
2715	48031296 (3673, 3674)			UNCLASSIFIED	1037
2716	43338371 (3685, 3686)			UNCLASSIFIED	1034
2717	94234975 (3693, 3694)			UNCLASSIFIED	1051
2718	79912451 (3707, 3708)			UNCLASSIFIED	1021, 1022
2719	19883421 (3717, 3718)			UNCLASSIFIED	1001
2720	29692576 (3719, 3720)			UNCLASSIFIED	1022
2721	79234687 (3723, 3724)			UNCLASSIFIED	1001
2722	78524159 (3727, 3728)			UNCLASSIFIED	1006
2723	78896169 (3751, 3752)			UNCLASSIFIED	1021, 1024, 1036
2724	78910498 (3761, 3762)			UNCLASSIFIED	1002
2725	57528838 (3763, 3764)			UNCLASSIFIED	1010
2726	46742605 (3777, 3778)			UNCLASSIFIED	1030
2727	79255205 (3781, 3782)			UNCLASSIFIED	1021
2728	51620802 (3797, 3798)			UNCLASSIFIED	1017
2729	10195575 (3799, 3800)			UNCLASSIFIED	1031
2730	79584454 (3809, 3810)			UNCLASSIFIED	1022
2731	65443082 (3815, 3816)			UNCLASSIFIED	1046
2732	79826942 (3819, 3820)			UNCLASSIFIED	1002, 1006, 1015, 1021,
					1036, 1041
2733	52559445 (3821, 3822)			UNCLASSIFIED	1055
2734	78299534 (3823, 3824)			UNCLASSIFIED	1024
2735	32164393 (3825, 3826)			UNCLASSIFIED	1021
2736	33099526 (3835, 3836)			UNCLASSIFIED	1024
2737	78374957 (3843, 3844)			UNCLASSIFIED	1024
2738	8907028 (3847, 3848)			UNCLASSIFIED	1021
2739	19753682 (3851, 3852)			UNCLASSIFIED	1035
2740	8487952 (3857, 3858)			UNCLASSIFIED	1020
2741	20283499 (3863, 3864)			UNCLASSIFIED	1031
2742	37798059 (3865, 3866)			UNCLASSIFIED	1010
2743	11302523 (3879, 3880)			UNCLASSIFIED	1022
2744	66309134 (3891, 3892)			UNCLASSIFIED	1050
2745	78528776 (3915, 3916)			UNCLASSIFIED	1024, 1041
2746	66031247 (3917, 3918)			UNCLASSIFIED	1050
2747	91253974 (3923, 3924)			UNCLASSIFIED	1008
2748	20267041 (3931, 3932)			UNCLASSIFIED	1031
2749	86665516 (3937, 3938)			UNCLASSIFIED	1017
2750	20195985 (3947, 3948)			UNCLASSIFIED	1008
2751	66258522 (3959, 3960)			UNCLASSIFIED	1006, 1008, 1022, 1035,
					1051
2752	80029779 (3975, 3976)			UNCLASSIFIED	1003, 1022, 1036
2753	79619003 (3979, 3980)			UNCLASSIFIED	1004, 1015
2754	11103584 (3981, 3982)			UNCLASSIFIED	1050
2755	11764404 (3983, 3984)			UNCLASSIFIED	1020
2756	33189196 (3985, 3986)			UNCLASSIFIED	1024
2757	34623151 (3999, 4000)			UNCLASSIFIED	1026
2758	8489122 (4011, 4012)			UNCLASSIFIED	1031
2759	78396490 (4023, 4024)			UNCLASSIFIED	1027
2760	29345892 (4037, 4038)			UNCLASSIFIED	1020
2761	29347340 (4039, 4040)			UNCLASSIFIED	1006
2762	55663357 (4041, 4042)			UNCLASSIFIED	1019
2763	11701316 (4065, 4066)			UNCLASSIFIED	1025
2764	20192246 (4069, 4070)			UNCLASSIFIED	1008
2765	27286869 (4071, 4072)			UNCLASSIFIED	1006
2766	25264269 (4077, 4078)			UNCLASSIFIED	1006, 1015
2767	11090696 (4083, 4084)			UNCLASSIFIED	1004
2768	79612603 (4099, 4100)			UNCLASSIFIED	1022
2769	79763149 (4105, 4106)			UNCLASSIFIED	1015
2770	78906237 (4115, 4116)			UNCLASSIFIED	1002, 1036
2771	95009140 (4123, 4124)			UNCLASSIFIED	1015
2772	20297255 (4133, 4134)			UNCLASSIFIED	1031
2773	34878135 (4141, 4142)			UNCLASSIFIED	1050
2774	20469119 (4145, 4146)			UNCLASSIFIED	1022
2775	91010108 (4147, 4148)			UNCLASSIFIED	1014, 1018
2776	78941152 (4169, 4170)			UNCLASSIFIED	1036
2777	65506240 (4181, 4182)			UNCLASSIFIED	1014
2778	79909566 (4191, 4192)			UNCLASSIFIED	1010, 1025, 1028
2779	25152088 (4201, 4202)			UNCLASSIFIED	1007
2780	30813844 (4205, 4206)			UNCLASSIFIED	1004
2781	29906897 (4209, 4210)			UNCLASSIFIED	1004
2782	78799491 (4217, 4218)			UNCLASSIFIED	1024
2783	29688099 (4233, 4234)			UNCLASSIFIED	1035
2784	77528564 (4235, 4236)			UNCLASSIFIED	1021
2785	20129211 (4241, 4242)			UNCLASSIFIED	1020
2786	56069291 (4255, 4256)			UNCLASSIFIED	1019
2787	32303790 (4263, 4264)			UNCLASSIFIED	1001
2788	29237787 (4277, 4278)			UNCLASSIFIED	1015
2789	80249583 (4279, 4280)			UNCLASSIFIED	1004
2790	78793467 (4281, 4282)			UNCLASSIFIED	1024
2791	79589721 (4283, 4284)			UNCLASSIFIED	1022
2792	80017549 (4293, 4294)			UNCLASSIFIED	1020, 1031
2793	78254116 (4301, 4302)			UNCLASSIFIED	1024
2794	30673102 (4307, 4308)			UNCLASSIFIED	1006
2795	20634834 (4339, 4340)			UNCLASSIFIED	1022
2796	40385109 (4351, 4352)			UNCLASSIFIED	1034
2797	79188918 (4357, 4358)			UNCLASSIFIED	1003, 1004, 1041, 1050
2798	78772029 (4369, 4370)			UNCLASSIFIED	1006
2799	80068312 (4375, 4376)			UNCLASSIFIED	1002, 1006, 1021, 1022,
					1023
2800	80254641 (4379, 4380)			UNCLASSIFIED	1008, 1031
2801	25250808 (4383, 4384)			UNCLASSIFIED	1036
2802	79445987 (4395, 4396)			UNCLASSIFIED	1022, 1055
2803	79831265 (4417, 4418)			UNCLASSIFIED	1021
2804	37811456 (4423, 4424)			UNCLASSIFIED	1055
2805	78941659 (4427, 4428)			UNCLASSIFIED	1014, 1021, 1035, 1036
2806	66373462 (4433, 4434)			UNCLASSIFIED	1051
2807	35106993 (4435, 4436)			UNCLASSIFIED	1024
2808	33205300 (4437, 4438)			UNCLASSIFIED	1024
2809	65894279 (4451, 4452)			UNCLASSIFIED	1015, 1035
2810	77686705 (4461, 4462)			UNCLASSIFIED	1022
2811	65667510 (4463, 4464)			UNCLASSIFIED	1020, 1050, 1051
2812	65650760 (4473, 4474)			UNCLASSIFIED	1051
2813	27933422 (4475, 4476)			UNCLASSIFIED	1004
2814	32584668 (4481, 4482)			UNCLASSIFIED	1026
2815	80417530 (4509, 4510)			UNCLASSIFIED	1004, 1006, 1010, 1022,
					1023, 1024, 1025, 1028,
					1031
2816	29353908 (4529, 4530)			UNCLASSIFIED	1020
2817	8697154 (4539, 4540)			UNCLASSIFIED	1020
2818	65986177 (4545, 4546)			UNCLASSIFIED	1051
2819	94630957 (4559, 4560)			UNCLASSIFIED	1015
2820	20469357 (4563, 4564)			UNCLASSIFIED	1022
2821	79588615 (4573, 4574)			UNCLASSIFIED	1031
2822	86668222 (4577, 4578)			UNCLASSIFIED	1026
2823	78915658 (4583, 4584)			UNCLASSIFIED	1006
2824	77474737 (4585, 4586)			UNCLASSIFIED	1021
2825	94234185 (4599, 4600)			UNCLASSIFIED	1051
2826	16295755 (4601, 4602)			UNCLASSIFIED	1051
2827	10368280 (4603, 4604)			UNCLASSIFIED	1015
2828	33205305 (4605, 4606)			UNCLASSIFIED	1024
2829	79552441 (4613, 4614)			UNCLASSIFIED	1001, 1020
2830	17940638 (4615, 4616)			UNCLASSIFIED	1036
2831	47652044 (4627, 4628)			UNCLASSIFIED	1026
2832	77882123 (4635, 4636)			UNCLASSIFIED	1039
2833	19505870 (4637, 4638)			UNCLASSIFIED	1006
2834	15028506 (4641, 4642)			UNCLASSIFIED	1051
2835	21631008 (4643, 4644)			UNCLASSIFIED	1036
2836	23286066 (4651, 4652)			UNCLASSIFIED	1036
2837	78944373 (4653, 4654)			UNCLASSIFIED	1002, 1014
2838	66372906 (4657, 4658)			UNCLASSIFIED	1035
2839	30673352 (4659, 4660)			UNCLASSIFIED	1027
2840	20700438 (4663, 4664)			UNCLASSIFIED	1031
2841	8373956 (4673, 4674)			UNCLASSIFIED	1008
2842	79619690 (4681, 4682)			UNCLASSIFIED	1003
2843	32420685 (4741, 4742)			UNCLASSIFIED	1010
2844	66317870 (4747, 4748)			UNCLASSIFIED	1007
2845	11285785 (4751, 4752)			UNCLASSIFIED	1004
2846	78923678 (4759, 4760)			UNCLASSIFIED	1035
2847	78049812 (4769, 4770)			UNCLASSIFIED	1024
2848	36524697 (4773, 4774)			UNCLASSIFIED	1026
2849	78050567 (4785, 4786)			UNCLASSIFIED	1006
2850	10122104 (4787, 4788)			UNCLASSIFIED	1041
2851	25149457 (4795, 4796)			UNCLASSIFIED	1024
2852	37800062 (4799, 4800)			UNCLASSIFIED	1010
2853	86669166 (4805, 4806)			UNCLASSIFIED	1035
2854	99115101 (4811, 4812)			UNCLASSIFIED	1008, 1018, 1024, 1031
2855	79441720 (4813, 4814)			UNCLASSIFIED	1022
2856	29690681 (4821, 4822)			UNCLASSIFIED	1022
2857	32306836 (4831, 4832)			UNCLASSIFIED	1022
2858	19641785 (4841, 4842)			UNCLASSIFIED	1031
2859	86465496 (4853, 4854)			UNCLASSIFIED	1017
2860	71457943 (4859, 4860)			UNCLASSIFIED	1006
2861	10108751 (4879, 4880)			UNCLASSIFIED	1010
2862	36511909 (4881, 4882)			UNCLASSIFIED	1024
2863	51627930 (4885, 4886)			UNCLASSIFIED	1039
2864	10355325 (4889, 4890)			UNCLASSIFIED	1036
2865	32443654 (4905, 4906)			UNCLASSIFIED	1001
2866	78100313 (4911, 4912)			UNCLASSIFIED	1020
2867	79473904 (4917, 4918)			UNCLASSIFIED	1035
2868	79389282 (4923, 4924)			UNCLASSIFIED	1055
2869	9848658 (4935, 4936)			UNCLASSIFIED	1021
2870	80445326 (4945, 4946)			UNCLASSIFIED	1035
2871	13076219 (4951, 4952)			UNCLASSIFIED	1022
2872	87458171 (4963, 4964)			UNCLASSIFIED	1016
2873	19908441 (4967, 4968)			UNCLASSIFIED	1031
2874	79565987 (5003, 5004)			UNCLASSIFIED	1015
2875	52208871 (5021, 5022)			UNCLASSIFIED	1033
2876	79247367 (5031, 5032)			UNCLASSIFIED	1036
2877	12605067 (5065, 5066)			UNCLASSIFIED	1028
2878	78462358 (5071, 5072)			UNCLASSIFIED	1024
2879	37809431 (5103, 5104)			UNCLASSIFIED	1055
2880	11757198 (5111, 5112)			UNCLASSIFIED	1022
2881	17117396 (5125, 5126)			UNCLASSIFIED	1006
2882	80019328 (5139, 5140)			UNCLASSIFIED	1014, 1020
2883	52563817 (5145, 5146)			UNCLASSIFIED	1002
2884	80053961 (5157, 5158)			UNCLASSIFIED	1008
2885	78745454 (5165, 5166)			UNCLASSIFIED	1036
2886	78747092 (5167, 5168)			UNCLASSIFIED	1020
2887	78470377 (5171, 5172)			UNCLASSIFIED	1024
2888	78374663 (5181, 5182)			UNCLASSIFIED	1006
2889	55504394 (5195, 5196)			UNCLASSIFIED	1019
2890	38633736 (5197, 5198)			UNCLASSIFIED	1024
2891	80189412 (5209, 5210)			UNCLASSIFIED	1055
2892	57005676 (5217, 5218)			UNCLASSIFIED	1006
2893	29674648 (5221, 5222)			UNCLASSIFIED	1027
2894	20379495 (5229, 5230)			UNCLASSIFIED	1020
2895	35139265 (5253, 5254)			UNCLASSIFIED	1047
2896	23297485 (5281, 5282)			UNCLASSIFIED	1002
2897	23303003 (5283, 5284)			UNCLASSIFIED	1021
2898	66051735 (5289, 5290)			UNCLASSIFIED	1008
2899	78780652 (5299, 5300)			UNCLASSIFIED	1007, 1022
2900	10885600 (5301, 5302)			UNCLASSIFIED	1025
2901	29350240 (5305, 5306)			UNCLASSIFIED	1041
2902	11013209 (5311, 5312)			UNCLASSIFIED	1004
2903	85537649 (5315, 5316)			UNCLASSIFIED	1035
2904	65471614 (5337, 5338)			UNCLASSIFIED	1046
2905	78261683 (5341, 5342)			UNCLASSIFIED	1020, 1024
2906	65653823 (5347, 5348)			UNCLASSIFIED	1014, 1020, 1051
2907	80250916 (5361, 5362)			UNCLASSIFIED	1001, 1020
2908	80308639 (5363, 5364)			UNCLASSIFIED	1015, 1020, 1023, 1026,
					1035
2909	65984526 (5367, 5368)			UNCLASSIFIED	1003
2910	95313695 (5397, 5398)			UNCLASSIFIED	1051
2911	35112059 (5403, 5404)			UNCLASSIFIED	1000
2912	66409534 (5409, 5410)			UNCLASSIFIED	1054
2913	80501511 (5411, 5412)			UNCLASSIFIED	1010
2914	79450450 (5415, 5416)			UNCLASSIFIED	1022
2915	17134146 (5417, 5418)			UNCLASSIFIED	1051
2916	30654359 (5419, 5420)			UNCLASSIFIED	1020
2917	85800817 (5429, 5430)			UNCLASSIFIED	1023
2918	10083535 (5441, 5442)			UNCLASSIFIED	1036
2919	66463935 (5449, 5450)			UNCLASSIFIED	1020, 1024
2920	79232559 (5467, 5468)			UNCLASSIFIED	1001, 1008
2921	80491888 (5479, 5480)			UNCLASSIFIED	1003, 1004, 1008, 1010,
					1020, 1024
2922	46848609 (5487, 5488)			UNCLASSIFIED	1051
2923	55003239 (5499, 5500)			UNCLASSIFIED	1017
2924	85526422 (5519, 5520)			UNCLASSIFIED	1035
2925	20384672 (5523, 5524)			UNCLASSIFIED	1003
2926	20290105 (5565, 5566)			UNCLASSIFIED	1020
2927	66376605 (5575, 5576)			UNCLASSIFIED	1007, 1008
2928	55996771 (5583, 5584)			UNCLASSIFIED	1036
2929	20292707 (5585, 5586)			UNCLASSIFIED	1031
2930	37799216 (5589, 5590)			UNCLASSIFIED	1010
2931	77666770 (5617, 5618)			UNCLASSIFIED	1002
2932	56517982 (5621, 5622)			UNCLASSIFIED	1017
2933	20754310 (5627, 5628)			UNCLASSIFIED	1050
2934	79319395 (5629, 5630)			UNCLASSIFIED	1031
2935	47652512 (5641, 5642)			UNCLASSIFIED	1026
2936	36857764 (5645, 5646)			UNCLASSIFIED	1014
2937	10330364 (5649, 5650)			UNCLASSIFIED	1023
2938	79582558 (5655, 5656)			UNCLASSIFIED	1020
2939	20288445 (5689, 5690)			UNCLASSIFIED	1031
2940	65681567 (5717, 5718)			UNCLASSIFIED	1022
2941	11077196 (5721, 5722)			UNCLASSIFIED	1031
2942	82474748 (5733, 5734)			UNCLASSIFIED	1001
2943	78753658 (5767, 5768)			UNCLASSIFIED	1006, 1015
2944	20296465 (5781, 5782)			UNCLASSIFIED	1031
2945	11815252 (5783, 5784)			UNCLASSIFIED	1022
2946	54532005 (5789, 5790)			UNCLASSIFIED	1038
2947	11204751 (5815, 5816)			UNCLASSIFIED	1020
2948	28450339 (5819, 5820)			UNCLASSIFIED	1036
2949	94720119 (5821, 5822)			UNCLASSIFIED	1002
2950	66390621 (5827, 5828)			UNCLASSIFIED	1035, 1051, 1055
2951	21391992 (5835, 5836)			UNCLASSIFIED	1004
2952	16541051 (5841, 5842)			UNCLASSIFIED	1006
2953	35112748 (5851, 5852)			UNCLASSIFIED	1027
2954	78528487 (5853, 5854)			UNCLASSIFIED	1027
2955	79876219 (5857, 5858)			UNCLASSIFIED	1015
2956	23289053 (5869, 5870)			UNCLASSIFIED	1015
2957	78494382 (5873, 5874)			UNCLASSIFIED	1024
2958	46664258 (5875, 5876)			UNCLASSIFIED	1051
2959	78736790 (5877, 5878)			UNCLASSIFIED	1015
2960	52561007 (5879, 5880)			UNCLASSIFIED	1010
2961	33763197 (5881, 5882)			UNCLASSIFIED	1024
2962	80236339 (5887, 5888)			UNCLASSIFIED	1020
2963	9681893 (5891, 5892)			UNCLASSIFIED	1041
2964	9843987 (5901, 5902)			UNCLASSIFIED	1021
2965	27966722 (5909, 5910)			UNCLASSIFIED	1020
2966	13506838 (5911, 5912)			UNCLASSIFIED	1022
2967	20442033 (5913, 5914)			UNCLASSIFIED	1020
2968	34405095 (5917, 5918)			UNCLASSIFIED	1035
2969	82337919 (5921, 5922)			UNCLASSIFIED	1001
2970	79617558 (5927, 5928)			UNCLASSIFIED	1001, 1027, 1041, 1051
2971	17943756 (5937, 5938)			UNCLASSIFIED	1022
2972	17302549 (5943, 5944)			UNCLASSIFIED	1041
2973	91253982 (5951, 5952)			UNCLASSIFIED	1008
2974	79552301 (5953, 5954)			UNCLASSIFIED	1015, 1035
2975	80419830 (5955, 5956)			UNCLASSIFIED	1023, 1031
2976	65655877 (5959, 5960)			UNCLASSIFIED	1051
2977	95293040 (5961, 5962)			UNCLASSIFIED	1002, 1004, 1021, 1022,
					1031, 1041
2978	69237168 (5969, 5970)			UNCLASSIFIED	1019, 1043
2979	78473178 (5983, 5984)			UNCLASSIFIED	1024
2980	94233942 (6005, 6006)			UNCLASSIFIED	1002
2981	78755288 (6017, 6018)			UNCLASSIFIED	1020
2982	78781759 (6025, 6026)			UNCLASSIFIED	1006, 1051
2983	80249147 (6031, 6032)			UNCLASSIFIED	1050
2984	10093452 (6041, 6042)			UNCLASSIFIED	1035
2985	87897855 (6043, 6044)			UNCLASSIFIED	1013, 1019, 1020, 1021,
					1024
2986	46738367 (6051, 6052)			UNCLASSIFIED	1030
2987	79860910 (6085, 6086)			UNCLASSIFIED	1015, 1036
2988	39730975 (6097, 6098)			UNCLASSIFIED	1024
2989	29438548 (6099, 6100)			UNCLASSIFIED	1027
2990	20435652 (6123, 6124)			UNCLASSIFIED	1020
2991	78375120 (6135, 6136)			UNCLASSIFIED	1002
2992	20721829 (6139, 6140)			UNCLASSIFIED	1004
2993	27980881 (6141, 6142)			UNCLASSIFIED	1004
2994	79955526 (6147, 6148)			UNCLASSIFIED	1035
2995	80422939 (6151, 6152)			UNCLASSIFIED	1023
2996	39549162 (6157, 6158)			UNCLASSIFIED	1035
2997	36828436 (6165, 6166)			UNCLASSIFIED	1051
2998	78081039 (6183, 6184)			UNCLASSIFIED	1034
2999	78798321 (6191, 6192)			UNCLASSIFIED	1021
3000	79450459 (6193, 6194)			UNCLASSIFIED	1014, 1027
3001	80026748 (6209, 6210)			UNCLASSIFIED	1003
3002	46849679 (6221, 6222)			UNCLASSIFIED	1026
3003	80048336 (6223, 6224)			UNCLASSIFIED	1022, 1035
3004	17960896 (6237, 6238)			UNCLASSIFIED	1002
3005	17299889 (6249, 6250)			UNCLASSIFIED	1036
3006	79631360 (6253, 6254)			UNCLASSIFIED	1002, 1006, 1031, 1041,
					1051
3007	30675647 (6261, 6262)			UNCLASSIFIED	1035
3008	13518952 (6263, 6264)			UNCLASSIFIED	1022
3009	66259287 (6281, 6282)			UNCLASSIFIED	1008
3010	19647813 (6285, 6286)			UNCLASSIFIED	1021
3011	20453705 (6301, 6302)			UNCLASSIFIED	1022
3012	79902410 (6303, 6304)			UNCLASSIFIED	1015
3013	27931275 (6305, 6306)			UNCLASSIFIED	1020
3014	54693932 (6315, 6316)			UNCLASSIFIED	1038
3015	90999120 (6317, 6318)			UNCLASSIFIED	1018
3016	65484158 (6325, 6326)			UNCLASSIFIED	1051
3017	20477502 (6331, 6332)			UNCLASSIFIED	1020
3018	79559129 (6347, 6348)			UNCLASSIFIED	1035
3019	55926174 (6359, 6360)			UNCLASSIFIED	1019
3020	13517862 (6369, 6370)			UNCLASSIFIED	1022
3021	20224774 (6379, 6380)			UNCLASSIFIED	1008
3022	35103193 (6381, 6382)			UNCLASSIFIED	1022
3023	11685173 (6389, 6390)			UNCLASSIFIED	1014
3024	86685348 (6393, 6394)			UNCLASSIFIED	1026
3025	88094407 (6395, 6396)			UNCLASSIFIED	1004
3026	80086844 (6407, 6408)			UNCLASSIFIED	1031
3027	17251202 (6411, 6412)			UNCLASSIFIED	1041
3028	78176813 (6419, 6420)			UNCLASSIFIED	1051
3029	55772356 (6435, 6436)			UNCLASSIFIED	1019
3030	21145996 (6443, 6444)			UNCLASSIFIED	1031
3031	94316383 (6445, 6446)			UNCLASSIFIED	1041
3032	21392707 (6451, 6452)			UNCLASSIFIED	1020
3033	77575168 (6475, 6476)			UNCLASSIFIED	1008
3034	46872028 (8483, 6484)			UNCLASSIFIED	1034
3035	78792118 (6487, 6488)			UNCLASSIFIED	1015, 1038, 1041
3036	13503334 (6503, 6504)			UNCLASSIFIED	1003
3037	79557475 (6509, 6510)			UNCLASSIFIED	1001, 1015
3038	85808026 (6533, 6534)			UNCLASSIFIED	1035, 1051
3039	10869938 (6565, 6566)			UNCLASSIFIED	1028
3040	47656841 (6579, 6580)			UNCLASSIFIED	1026, 1050
3041	78186634 (6589, 6590)			UNCLASSIFIED	1020
3042	27965668 (6599, 6600)			UNCLASSIFIED	1050
3043	20296469 (6601, 6602)			UNCLASSIFIED	1031
3044	29470716 (6603, 6604)			UNCLASSIFIED	1020
3045	27848604 (6623, 6624)			UNCLASSIFIED	1008
3046	11618229 (6625, 6626)			UNCLASSIFIED	1022
3047	20705372 (6629, 6630)			UNCLASSIFIED	1020
3048	17678569 (6631, 6632)			UNCLASSIFIED	1006
3049	36996838 (6639, 6640)			UNCLASSIFIED	1001
3050	80231041 (6653, 6654)			UNCLASSIFIED	1003, 1004, 1008, 1015,
					1026
3051	11101673 (6657, 6658)			UNCLASSIFIED	1004
3052	78956581 (6661, 6662)			UNCLASSIFIED	1027
3053	13513193 (6665, 6666			UNCLASSIFIED	1022
3054	16554697 (6723, 6724)			UNCLASSIFIED	1021
3055	65695673 (6725, 6726)			UNCLASSIFIED	1035
3056	79856323 (6739, 6740)			UNCLASSIFIED	1015
3057	55658308 (6745, 6746)			UNCLASSIFIED	1019
3058	17930585 (6749, 6750)			UNCLASSIFIED	1021
3059	78093908 (6755, 6756)			UNCLASSIFIED	1030
3060	80500815 (6775, 6776)			UNCLASSIFIED	1010, 1050, 1055
3061	27966001 (6779, 6780)			UNCLASSIFIED	1031
3062	65878974 (6785, 6786)			UNCLASSIFIED	1014
3063	21429156 (6787, 6788)			UNCLASSIFIED	1020
3064	47654581 (6791, 6792)			UNCLASSIFIED	1026
3065	17876791 (6799, 6800)			UNCLASSIFIED	1022
3066	55996267 (6809, 6810)			UNCLASSIFIED	1024
3067	46778724 (6811, 6812)			UNCLASSIFIED	1019
3068	65447753 (6825, 6826)			UNCLASSIFIED	1046
3069	80500325 (6839, 6840)			UNCLASSIFIED	1010
3070	30264538 (6849, 6850)			UNCLASSIFIED	1024
3071	51994325 (6875, 6876)			UNCLASSIFIED	1033
3072	11799469 (6887, 6888)			UNCLASSIFIED	1023
3073	52204302 (6899, 6900)			UNCLASSIFIED	1037
3074	46849293 (6915, 6916)			UNCLASSIFIED	1026
3075	20620141 (6949, 6950)			UNCLASSIFIED	1020
3076	65656389 (6963, 6964)			UNCLASSIFIED	1051
3077	19897778 (6977, 6978)			UNCLASSIFIED	1004
3078	17898426 (6981, 6982)			UNCLASSIFIED	1041
3079	16410802 (6983, 6984)			UNCLASSIFIED	1027
3080	78941320 (6985, 6986)			UNCLASSIFIED	1020, 1036
3081	20286852 (6987, 6988)			UNCLASSIFIED	1031
3082	55770575 (6991, 6992)			UNCLASSIFIED	1021
3083	78945845 (7007, 7008)			UNCLASSIFIED	1006
3084	12921525 (7015, 7016)			UNCLASSIFIED	1003
3085	65496189 (7045, 7046)			UNCLASSIFIED	1021
3086	79632486 (7069, 7070)			UNCLASSIFIED	1002, 1023
3087	17960030 (7081, 7082)			UNCLASSIFIED	1021
3088	78971362 (7165, 7166)			UNCLASSIFIED	1006
3089	11384396 (7169, 7170)			UNCLASSIFIED	1014
3090	33103430 (7219, 7220)			UNCLASSIFIED	1024
3091	20438888 (7223, 7224)			UNCLASSIFIED	1022
3092	79436062 (7227, 7228)			UNCLASSIFIED	1008
3093	52417339 (7235, 7236)			UNCLASSIFIED	1033
3094	77600143 (7253, 7254)			UNCLASSIFIED	1008
3095	8239643 (7267, 7268)			UNCLASSIFIED	1020
3096	20467332 (7287, 7288)			UNCLASSIFIED	1008
3097	25256962 (7313, 7314)			UNCLASSIFIED	1006
3098	79440837 (7317, 7318)			UNCLASSIFIED	1020
3099	10049030 (7319, 7320)			UNCLASSIFIED	1021
3100	55406866 (7341, 7342)			UNCLASSIFIED	1019
3101	11765194 (7343, 7344)			UNCLASSIFIED	1020
3102	36521536 (7345, 7346)			UNCLASSIFIED	1026
3103	55778544 (7353, 7354)			UNCLASSIFIED	1039
3104	80218979 (7355, 7356)			UNCLASSIFIED	1003, 1020
3105	80231372 (7373, 7374)			UNCLASSIFIED	1020
3106	16494088 (7381, 7382)			UNCLASSIFIED	1006
3107	35049221 (7389, 7390)			UNCLASSIFIED	1027
3108	28130270 (7391, 7392)			UNCLASSIFIED	1023
3109	27850077 (7397, 7398)			UNCLASSIFIED	1008
3110	27981953 (7409, 7410)			UNCLASSIFIED	1020
3111	88097857 (7425, 7426)			UNCLASSIFIED	1016
3112	29466792 (7429, 7430)			UNCLASSIFIED	1020
3113	87467657 (7433, 7434)			UNCLASSIFIED	1001, 1004, 1010, 1014,
					1015, 1016, 1027, 1031
3114	47652650 (7455, 7456)			UNCLASSIFIED	1026
3115	79260338 (7481, 7482)			UNCLASSIFIED	1002, 1020, 1021, 1024
3116	79846868 (7491, 7492)			UNCLASSIFIED	1004, 1022
3117	95006559 (7493, 7494)			UNCLASSIFIED	1001, 1022, 1041, 1051
3118	65690426 (7495, 7496)			UNCLASSIFIED	1041, 1046, 1051
3119	65852425 (7497, 7498)			UNCLASSIFIED	1035
3120	13085439 (7499, 7500)			UNCLASSIFIED	1025
3121	15004014 (7505, 7506)			UNCLASSIFIED	1022
3122	11102062 (7511, 7512)			UNCLASSIFIED	1050
3123	39402420 (7519, 7520)			UNCLASSIFIED	1022
3124	39707534 (7545, 7546)			UNCLASSIFIED	1036
3125	19752152 (7547, 7548)			UNCLASSIFIED	1014
3126	9358875 (7551, 7552)			UNCLASSIFIED	1015
3127	25236002 (7555, 7556)			UNCLASSIFIED	1002
3128	9857259 (7563, 7564)			UNCLASSIFIED	1006
3129	15023397 (7567, 7568)			UNCLASSIFIED	1022
3130	79581081 (7579, 7580)			UNCLASSIFIED	1003
3131	21135804 (7587, 7588)			UNCLASSIFIED	1020
3132	80249151 (7593, 7594)			UNCLASSIFIED	1004, 1014, 1015, 1020,
					1021, 1031
3133	66471968 (7601, 7602)			UNCLASSIFIED	1026
3134	47656721 (7623, 7624)			UNCLASSIFIED	1026
3135	95010698 (7627, 7628)			UNCLASSIFIED	1015, 1021, 1022
3136	79581738 (7643, 7644)			UNCLASSIFIED	1020
3137	55393466 (7655, 7656)			UNCLASSIFIED	1000
3138	6344770 (7683, 7684)			UNCLASSIFIED	1055
3139	77911852 (7685, 7686)			UNCLASSIFIED	1033
3140	10170528 (7689, 7690)			UNCLASSIFIED	1031
3141	11337885 (7695, 7696)			UNCLASSIFIED	1031
3142	24143784 (7709, 7710)			UNCLASSIFIED	1002
3143	27971022 (7713, 7714)			UNCLASSIFIED	1020
3144	11412586 (7715, 7716)			UNCLASSIFIED	1015
3145	56161955 (7717, 7718)			UNCLASSIFIED	1015
3146	78071766 (7723, 7724)			UNCLASSIFIED	1022
3147	11397949 (7747, 7748)			UNCLASSIFIED	1020
3148	70144465 (7765, 7766)			UNCLASSIFIED	1035, 1046
3149	25136585 (7767, 7768)			UNCLASSIFIED	1024
3150	78985230 (7771, 7772)			UNCLASSIFIED	1014
3151	17886105 (7785, 7786)			UNCLASSIFIED	1022
3152	71332385 (7795, 7796)			UNCLASSIFIED	1000
3153	79483561 (7807, 7808)			UNCLASSIFIED	1004
3154	79964152 (7817, 7818)			UNCLASSIFIED	1004, 1031
3155	24115868 (7851, 7852)			UNCLASSIFIED	1036, 1041
3156	34761535 (7853, 7854)			UNCLASSIFIED	1027
3157	90980639 (7857, 7858)			UNCLASSIFIED	1018, 1035
3158	78460910 (7875, 7876)			UNCLASSIFIED	1006
3159	71449936 (7879, 7880)			UNCLASSIFIED	1010, 1021, 1051
3160	34080055 (7883, 7884)			UNCLASSIFIED	1000
3161	27803085 (7887, 7888)			UNCLASSIFIED	1031
3162	65876043 (7893, 7894)			UNCLASSIFIED	1014, 1041
3163	20465672 (7915, 7916)			UNCLASSIFIED	1008
3164	20629178 (7919, 7920)			UNCLASSIFIED	1031
3165	42723578 (7927, 7928)			UNCLASSIFIED	1000
3166	91231745 (7941, 7942)			UNCLASSIFIED	1008, 1042
3167	79848821 (7957, 7958)			UNCLASSIFIED	1051
3168	23291753 (7969, 7970)			UNCLASSIFIED	1002
3169	28468723 (7973, 7974)			UNCLASSIFIED	1027
3170	20435014 (7977, 7978)			UNCLASSIFIED	1020, 1022
3171	20371520 (7983, 7984)			UNCLASSIFIED	1003
3172	11753273 (8049, 8050)			UNCLASSIFIED	1035
3173	79255059 (8055, 8056)			UNCLASSIFIED	1035
3174	13076231 (8059, 8060)			UNCLASSIFIED	1020, 1025
3175	29445415 (8069, 8070)			UNCLASSIFIED	1020
3176	21412950 (8089, 8090)			UNCLASSIFIED	1020
3177	20557853 (8093, 8094)			UNCLASSIFIED	1055
3178	10297654 (8099, 8100)			UNCLASSIFIED	1023
3179	79921444 (8119, 8120)			UNCLASSIFIED	1006, 1035
3180	13046619 (8129, 8130)			UNCLASSIFIED	1022
3181	80052603 (8131, 8132)			UNCLASSIFIED	1008
3182	88094415 (8157, 8158)			UNCLASSIFIED	1004
3183	94317560 (8175, 8176)			UNCLASSIFIED	1014, 1041
3184	30536559 (8177, 8178)			UNCLASSIFIED	1024
3185	79553582 (8179, 8180)			UNCLASSIFIED	1036
3186	87566014 (8181, 8182)			UNCLASSIFIED	1020, 1031
3187	87451679 (8189, 8190)			UNCLASSIFIED	1016
3188	33189201 (8193, 8194)			UNCLASSIFIED	1024
3189	21639748 (8199, 8200)			UNCLASSIFIED	1021
3190	20732391 (8201, 8202)			UNCLASSIFIED	1020
3191	66429440 (8203, 8204)			UNCLASSIFIED	1022
3192	88097049 (8205, 8206)			UNCLASSIFIED	1023
3193	78961840 (8215, 8216)			UNCLASSIFIED	1015, 1036
3194	13527718 (8221, 8222)			UNCLASSIFIED	1001
3195	86466492 (8231, 8232)			UNCLASSIFIED	1026
3196	9896187 (8233, 8234)			UNCLASSIFIED	1036
3197	20442005 (8243, 8244)			UNCLASSIFIED	1022
3198	65885116 (8257, 8258)			UNCLASSIFIED	1051
3199	9383513 (8269, 8270)			UNCLASSIFIED	1015
3200	65686238 (8273, 8274)			UNCLASSIFIED	1043
3201	11693032 (8301, 8302)			UNCLASSIFIED	1004
3202	65976617 (8309, 8310)			UNCLASSIFIED	1050
3203	30395700 (8311, 8312)			UNCLASSIFIED	1024
3204	78977482 (8315, 8316)			UNCLASSIFIED	1002
3205	11816872 (8325, 8326)			UNCLASSIFIED	1003
3206	78299281 (8327, 8328)			UNCLASSIFIED	1035
3207	71762302 (8329, 8330)			UNCLASSIFIED	1021, 1033
3208	17659316 (8331, 8332)			UNCLASSIFIED	1002
3209	36989187 (8347, 8348)			UNCLASSIFIED	1014
3210	79475887 (8351, 8352)			UNCLASSIFIED	1035
3211	52560939 (8353, 8354)			UNCLASSIFIED	1010
3212	80212643 (8361, 8362)			UNCLASSIFIED	1000, 1022, 1047
3213	30638999 (8363, 8364)			UNCLASSIFIED	1006
3214	20293333 (8381, 8382)			UNCLASSIFIED	1020
3215	97992805 (8393, 8394)			UNCLASSIFIED	1002, 1031, 1041, 1051
3216	78678461 (8405, 8406)			UNCLASSIFIED	1006
3217	79754436 (8407, 8408)			UNCLASSIFIED	1008
3218	79852731 (8415, 8416)			UNCLASSIFIED	1015
3219	20161651 (8425, 8426)			UNCLASSIFIED	1008
3220	78157112 (8433, 8434)			UNCLASSIFIED	1000, 1024
3221	43155046 (8451, 8452)			UNCLASSIFIED	1034
3222	33202172 (8467, 8468)			UNCLASSIFIED	1024
3223	18561492 (8471, 8472)			UNCLASSIFIED	1001
3224	9384481 (8473, 8474)			UNCLASSIFIED	1015
3225	47666079 (8479, 8480)			UNCLASSIFIED	1051
3226	25154862 (8481, 8482)			UNCLASSIFIED	1002
3227	56426884 (8483, 8484)			UNCLASSIFIED	1002, 1035
3228	78781584 (8509, 8510)			UNCLASSIFIED	1024
3229	80572331 (8511, 8512)			UNCLASSIFIED	1002, 1006, 1015, 1020,
					1021, 1036, 1055
3230	71093450 (8537, 8538)			UNCLASSIFIED	1050
3231	57056549 (8545, 8546)			UNCLASSIFIED	1051
3232	80246765 (8559, 8560)			UNCLASSIFIED	1020
3233	71754055 (8567, 8568)			UNCLASSIFIED	1006
3234	29262665 (8575, 8576)			UNCLASSIFIED	1007
3235	56069130 (8595, 9596)			UNCLASSIFIED	1019
3236	80084472 (8629, 8630)			UNCLASSIFIED	1031
3237	10127784 (8661, 8662)			UNCLASSIFIED	1015
3238	30664656 (8673, 8674)			UNCLASSIFIED	1020
3239	55778583 (8697, 8698)			UNCLASSIFIED	1039
3240	57304771 (8699, 8700)			UNCLASSIFIED	1002, 1004, 1031
3241	30540756 (8719, 8720)			UNCLASSIFIED	1024
3242	20710306 (8735, 8736)			UNCLASSIFIED	1020
3243	78788014 (8739, 8740)			UNCLASSIFIED	1007
3244	79831111 (8741, 8742)			UNCLASSIFIED	1021
3245	80083760 (8751, 8752)			UNCLASSIFIED	1001, 1015
3246	78261877 (8755, 8756)			UNCLASSIFIED	1004
3247	36857037 (8769, 8770)			UNCLASSIFIED	1014
3248	88068123 (8771, 8772)			UNCLASSIFIED	1015, 1031
3249	80068172 (8783, 8784)			UNCLASSIFIED	1020
3250	19879414 (8797, 8798)			UNCLASSIFIED	1031
3251	78903885 (8801, 8802)			UNCLASSIFIED	1041
3252	28775733 (8823, 8824)			UNCLASSIFIED	1041
3253	91228881 (8859, 8860)			UNCLASSIFIED	1008
3254	33204368 (8863, 8864)			UNCLASSIFIED	1024
3255	23294321 (8869, 8870)			UNCLASSIFIED	1021
3256	79854040 (8875, 8876)			UNCLASSIFIED	1041
3257	28384303 (8887, 8888)			UNCLASSIFIED	1041
3258	33097932 (8889, 8890)			UNCLASSIFIED	1010
3259	80307643 (8891, 8892)			UNCLASSIFIED	1002, 1003, 1004, 1006,
					1015, 1021, 1025, 1026,
					1031
3260	86475489 (8899, 8900)			UNCLASSIFIED	1045
3261	33207420 (8919, 8920)			UNCLASSIFIED	1024
3262	65878422 (8927, 8928)			UNCLASSIFIED	1041
3263	10101835 (8935, 8936)			UNCLASSIFIED	1014
3264	78784267 (8953, 8954)			UNCLASSIFIED	1002, 1020
3265	51579562 (8959, 8960)			UNCLASSIFIED	1033
3266	20372405 (8969, 8970)			UNCLASSIFIED	1008
3267	79491061 (8973, 8974)			UNCLASSIFIED	1003, 1004, 1021
3268	78438658 (8983, 8984)			UNCLASSIFIED	1051
3269	20288783 (8995, 8996)			UNCLASSIFIED	1020
3270	94324476 (9001, 9002)			UNCLASSIFIED	1001, 1002, 1020
3271	79628162 (9011, 9012)			UNCLASSIFIED	1036
3272	36830398 (9013, 9014)			UNCLASSIFIED	1051
3273	19847912 (9023, 9024)			UNCLASSIFIED	1031
3274	21414034 (9035, 9036)			UNCLASSIFIED	1020
3275	10088537 (9047, 9048)			UNCLASSIFIED	1015
3276	58092544 (9049, 9050)			UNCLASSIFIED	1035
3277	46894759 (9059, 9060)			UNCLASSIFIED	1017
3278	78501937 (9063, 9064)			UNCLASSIFIED	1024
3279	42724351 (3, 4)			UNCLASSIFIED	1034
3280	9671467 (11, 12)			UNCLASSIFIED	1021
3281	10873421 (13, 14)			UNCLASSIFIED	1003
3282	18558895 (19, 20)			UNCLASSIFIED	1055
3283	16843354 (23, 24)			UNCLASSIFIED	1004, 1010, 1022, 1028,
					1036
3284	47652713 (27, 28)			UNCLASSIFIED	1026
3285	21429024 (31, 32)			UNCLASSIFIED	1050
3286	23209460 (37, 38)			UNCLASSIFIED	1002
3287	65499601 (39, 40)			UNCLASSIFIED	1035
3288	98186999 (43, 44)			UNCLASSIFIED	1031
3289	85543986 (45, 46)			UNCLASSIFIED	1002, 1003, 1004, 1006,
					1014, 1020, 1022, 1024,
					1025, 1031, 1035, 1036,
					1041
3290	27976881 (49, 50)			UNCLASSIFIED	1020
3291	20614060 (55, 56)			UNCLASSIFIED	1008
3292	95012728 (59, 60)			UNCLASSIFIED	1002, 1008
3293	65641290 (71, 72)			UNCLASSIFIED	1038
3294	94662319 (73, 74)			UNCLASSIFIED	1004, 1022, 1025, 1028,
					1036, 1041
3295	29464115 (83, 84)			UNCLASSIFIED	1035
3296	79753822 (95, 96)			UNCLASSIFIED	1008
3297	79251277 (99, 100)			UNCLASSIFIED	1022
3298	86665092 (101, 102)			UNCLASSIFIED	1017
3299	95087962 (109, 110)			UNCLASSIFIED	1041
3300	54526644 (113, 114)			UNCLASSIFIED	1038
3301	79636146 (115, 116)			UNCLASSIFIED	1020, 1021
3302	11294555 (119, 120)			UNCLASSIFIED	1008
3303	46869437 (125, 126)			UNCLASSIFIED	1034
3304	79844198 (133, 134)			UNCLASSIFIED	1006
3305	54533896 (139, 140)			UNCLASSIFIED	1038
3306	79813912 (151, 152)			UNCLASSIFIED	1015, 1041
3307	86467083 (153, 154)			UNCLASSIFIED	1026
3308	33197987 (159, 160)			UNCLASSIFIED	1047
3309	35345394 (173, 174)			UNCLASSIFIED	1024
3310	78736010 (179, 180)			UNCLASSIFIED	1002
3311	27831430 (185, 186)			UNCLASSIFIED	1008, 1022
3312	78160561 (189, 190)			UNCLASSIFIED	1026
3313	66256488 (193, 194)			UNCLASSIFIED	1014, 1024, 1033
3314	33181887 (215, 216)			UNCLASSIFIED	1024
3315	55929027 (227, 228)			UNCLASSIFIED	1019
3316	87116679 (231, 232)			UNCLASSIFIED	1023
3317	78470548 (243, 244)			UNCLASSIFIED	1041
3318	91235523 (249, 250)			UNCLASSIFIED	1008
3319	29495855 (251, 252)			UNCLASSIFIED	1035
3320	8010672 (253, 254)			UNCLASSIFIED	1020
3321	20636023 (255, 256)			UNCLASSIFIED	1003
3322	30494282 (259, 260)			UNCLASSIFIED	1007
3323	80230515 (265, 266)			UNCLASSIFIED	1007, 1020
3324	78060488 (267, 268)			UNCLASSIFIED	1022
3325	79251749 (273, 274)			UNCLASSIFIED	1002, 1015, 1026
3326	27356164 (289, 290)			UNCLASSIFIED	1024
3327	98102065 (295, 296)			UNCLASSIFIED	1035, 1041
3328	33454848 (297, 298)			UNCLASSIFIED	1026
3329	19883215 (303, 304)			UNCLASSIFIED	1001
3330	56151434 (311, 312)			UNCLASSIFIED	1021
3331	55659811 (313, 314)			UNCLASSIFIED	1039
3332	10344257 (319, 320)			UNCLASSIFIED	1021
3333	80194905 (325, 326)			UNCLASSIFIED	1020, 1031, 1035
3334	29508428 (329, 330)			UNCLASSIFIED	1035
3335	497496 (337, 338)			UNCLASSIFIED	1051
3336	65467524 (355, 356)			UNCLASSIFIED	1051
3337	80079474 (357, 358)			UNCLASSIFIED	1031
3338	94252313 (359, 360)			UNCLASSIFIED	1036
3339	16549173 (361, 362)			UNCLASSIFIED	1035
3340	30788088 (379, 380)			UNCLASSIFIED	1006, 1015, 1020, 1024,
					1036
3341	95010088 (381, 382)			UNCLASSIFIED	1041
3342	46571395 (387, 388)			UNCLASSIFIED	1026
3343	35344642 (389, 390)			UNCLASSIFIED	1024
3344	66255543 (405, 406)			UNCLASSIFIED	1014
3345	78276305 (407, 408)			UNCLASSIFIED	1026
3346	10323955 (427, 428)			UNCLASSIFIED	1023
3347	66429806 (429, 430)			UNCLASSIFIED	1022
3348	6312912 (431, 432)			UNCLASSIFIED	1055
3349	79200408 (433, 434)			UNCLASSIFIED	1025
3350	71456050 (443, 444)			UNCLASSIFIED	1024, 1041
3351	71059716 (449, 450)			UNCLASSIFIED	1033
3352	25265924 (451, 452)			UNCLASSIFIED	1036
3353	17086703 (453, 454)			UNCLASSIFIED	1021
3354	49506863 (457, 458)			UNCLASSIFIED	1033
3355	17299518 (459, 460)			UNCLASSIFIED	1041
3356	65447083 (483, 484)			UNCLASSIFIED	1014
3357	55007000 (497, 498)			UNCLASSIFIED	1017
3358	55870673 (513, 514)			UNCLASSIFIED	1022
3359	39527184 (519, 520)			UNCLASSIFIED	1004
3360	79257303 (537, 538)			UNCLASSIFIED	1041
3361	16511341 (549, 550)			UNCLASSIFIED	1051
3362	66405131 (555, 556)			UNCLASSIFIED	1022, 1051
3363	17894241 (561, 562)			UNCLASSIFIED	1006
3364	78305241 (567, 568)			UNCLASSIFIED	1017, 1047
3365	77556055 (577, 578)			UNCLASSIFIED	1051
3366	78798198 (583, 584)			UNCLASSIFIED	1024
3367	6433872 (591, 592)			UNCLASSIFIED	1055
3368	19528852 (613, 614)			UNCLASSIFIED	1031
3369	27972001 (617, 618)			UNCLASSIFIED	1004
3370	94256159 (621, 622)			UNCLASSIFIED	1006
3371	56068101 (623, 624)			UNCLASSIFIED	1019
3372	80385281 (629, 630)			UNCLASSIFIED	1002, 1026, 1041
3373	78465177 (631, 632)			UNCLASSIFIED	1036
3374	25322681 (635, 636)			UNCLASSIFIED	1002
3375	95002687 (647, 648)			UNCLASSIFIED	1004
3376	33185125 (649, 650)			UNCLASSIFIED	1024
3377	57301576 (655, 656)			UNCLASSIFIED	1003, 1022, 1031
3378	25238790 (659, 660)			UNCLASSIFIED	1015
3379	71803174 (663, 664)			UNCLASSIFIED	1007
3380	29207301 (665, 666)			UNCLASSIFIED	1006
3381	65682422 (667, 668)			UNCLASSIFIED	1043, 1051
3382	79549187 (669, 670)			UNCLASSIFIED	1035
3383	79843373 (687, 688)			UNCLASSIFIED	1004, 1041
3384	95293067 (697, 698)			UNCLASSIFIED	1020
3385	86693074 (703, 704)			UNCLASSIFIED	1023
3386	55004490 (711, 712)			UNCLASSIFIED	1017
3387	78705380 (713, 714)			UNCLASSIFIED	1002
3388	33763694 (717, 718)			UNCLASSIFIED	1024
3389	46682611 (721, 722)			UNCLASSIFIED	1026
3390	85541861 (727, 728)			UNCLASSIFIED	1051
3391	65466222 (729, 730)			UNCLASSIFIED	1051
3392	42563061 (737, 738)			UNCLASSIFIED	1000
3393	79862067 (743, 744)			UNCLASSIFIED	1001, 1004, 1020, 1023,
					1024, 1035
3394	10299479 (755, 756)			UNCLASSIFIED	1035
3395	32714312 (783, 784)			UNCLASSIFIED	1026
3396	17860909 (789, 790)			UNCLASSIFIED	1023
3397	77936327 (791, 792)			UNCLASSIFIED	1038
3398	79558046 (793, 794)			UNCLASSIFIED	1023
3399	20289261 (805, 806)			UNCLASSIFIED	1008
3400	46880097 (807, 808)			UNCLASSIFIED	1038
3401	94675674 (811, 812			UNCLASSIFIED	1020
3402	80258532 (813, 814)			UNCLASSIFIED	1004, 1036
3403	28390881 (821, 822)			UNCLASSIFIED	1041
3404	65703884 (825, 826)			UNCLASSIFIED	1035
3405	17679461 (829, 830)			UNCLASSIFIED	1015
3406	65455792 (835, 836)			UNCLASSIFIED	1014
3407	11686712 (839, 840)			UNCLASSIFIED	1028
3408	20288463 (841, 842)			UNCLASSIFIED	1031
3409	38066871 (849, 850)			UNCLASSIFIED	1020
3410	86667171 (853, 854)			UNCLASSIFIED	1026
3411	350711826 (893, 894)			UNCLASSIFIED	1022
3412	77801266 (911, 912)			UNCLASSIFIED	1051
3413	79209954 (915, 916)			UNCLASSIFIED	1033, 1051
3414	77529068 (921, 922)			UNCLASSIFIED	1035
3415	27360362 (925, 926)			UNCLASSIFIED	1024
3416	86474069 (935, 936)			UNCLASSIFIED	1051
3417	36621578 (945, 946)			UNCLASSIFIED	1031
3418	20297495 (949, 950)			UNCLASSIFIED	1020
3419	51626084 (953, 954)			UNCLASSIFIED	1037
3420	56073185 (959, 960)			UNCLASSIFIED	1019
3421	46866733 (961, 962)			UNCLASSIFIED	1034
3422	65445597 (965, 966)			UNCLASSIFIED	1035
3423	80083883 (975, 976)			UNCLASSIFIED	1001
3424	66437277 (977, 978)			UNCLASSIFIED	1022
3425	78392589 (979, 980)			UNCLASSIFIED	1027
3426	78378977 (991, 992)			UNCLASSIFIED	1006
3427	38215166 (997, 998)			UNCLASSIFIED	1051
3428	77890053 (1005, 1006)			UNCLASSIFIED	1033
3429	28987357 (1009, 1010)			UNCLASSIFIED	1020
3430	79222721 (1013, 1014)			UNCLASSIFIED	1022
3431	80369313 (1015, 1016)			UNCLASSIFIED	1026
3432	55286477 (1025, 1026)			UNCLASSIFIED	1026, 1050
3433	66153753 (1029, 1030)			UNCLASSIFIED	1002
3434	79635191 (1043, 1044)			UNCLASSIFIED	1021
3435	79563375 (1049, 1050)			UNCLASSIFIED	1006, 1051
3436	55183771 (1051, 1052)			UNCLASSIFIED	1017, 1031
3437	16738258 (1053, 1054)			UNCLASSIFIED	1015
3438	33764350 (1061, 1062)			UNCLASSIFIED	1024
3439	86469728 (1073, 1074)			UNCLASSIFIED	1026
3440	71241798 (1077, 1078)			UNCLASSIFIED	1000, 1051
3441	20291697 (1083, 1084)			UNCLASSIFIED	1031
3442	80502240 (1091, 1092)			UNCLASSIFIED	1004, 1010
3443	79574044 (1097, 1098)			UNCLASSIFIED	1004, 1006, 1028, 1046
3444	35066728 (1101, 1102)			UNCLASSIFIED	1051
3445	10347926 (1103, 1104)			UNCLASSIFIED	1023
3446	65978393 (1107, 1108)			UNCLASSIFIED	1051
3447	34751949 (1111, 1112)			UNCLASSIFIED	1027
3448	78794381 (1127, 1128)			UNCLASSIFIED	1024
3449	33099346 (1135, 1136)			UNCLASSIFIED	1024
3450	11100234 (1149, 1150)			UNCLASSIFIED	1020
3451	78945010 (1151, 1152)			UNCLASSIFIED	1027
3452	47657283 (1153, 1154)			UNCLASSIFIED	1026
3453	71219199 (1161, 1162)			UNCLASSIFIED	1026, 1038
3454	78275056 (1163, 1164)			UNCLASSIFIED	1035
3455	79392487 (1165, 1166)			UNCLASSIFIED	1041, 1055
3456	85822780 (1171, 1172)			UNCLASSIFIED	1045
3457	77876079 (1185, 1186)			UNCLASSIFIED	1017
3458	3513946 (1215, 1216)			UNCLASSIFIED	1047
3459	80028175 (1221, 1222)			UNCLASSIFIED	1020, 1031
3460	77883606 (1223, 1224)			UNCLASSIFIED	1019
3461	20466792 (1227, 1228)			UNCLASSIFIED	1008
3462	94316162 (1229, 1230)			UNCLASSIFIED	1002
3463	35011451 (1235, 1236)			UNCLASSIFIED	1051
3464	27848590 (1241, 1242)			UNCLASSIFIED	1008
3465	79245745 (1245, 1246)			UNCLASSIFIED	1006, 1022
3466	86685014 (1247, 1248)			UNCLASSIFIED	1011
3467	29272926 (1295, 1296)			UNCLASSIFIED	1020
3468	7648895 (1329, 1330)			UNCLASSIFIED	1031
3469	29455226 (1337, 1338)			UNCLASSIFIED	1051
3470	65896870 (1339, 1340)			UNCLASSIFIED	1051
3471	80491729 (1345, 1346)			UNCLASSIFIED	1002, 1004, 1010, 1020,
					1022, 1036, 1041
3472	65451093 (1349, 1350)			UNCLASSIFIED	1014
3473	79316465 (1353, 1354)			UNCLASSIFIED	1003
3474	80104668 (1371, 1372)			UNCLASSIFIED	1004, 1021
3475	82401333 (1389, 1390)			UNCLASSIFIED	1001, 1007
3476	46855997 (1393, 1394)			UNCLASSIFIED	1034
3477	11614944 (1399, 1400)			UNCLASSIFIED	1014
3478	37026044 (1417, 1418)			UNCLASSIFIED	1035
3479	66395996 (1419, 1420)			UNCLASSIFIED	1006
3480	65706567 (1421, 1422)			UNCLASSIFIED	1035
3481	11759684 (1427, 1428)			UNCLASSIFIED	1014
3482	78196286 (1453, 1454)			UNCLASSIFIED	1020
3483	80032497 (1461, 1462)			UNCLASSIFIED	1020
3484	71450178 (1467, 1468)			UNCLASSIFIED	1024, 1026
3485	34089531 (1469, 1470)			UNCLASSIFIED	1000
3486	25147774 (1479, 1480)			UNCLASSIFIED	1003, 1024, 1031
3487	47660070 (1489, 1490)			UNCLASSIFIED	1026
3488	78959481 (1501, 1502)			UNCLASSIFIED	1002
3489	6604102 (1503, 1504)			UNCLASSIFIED	1020
3490	30796416 (1515, 1516)			UNCLASSIFIED	1026
3491	28489177 (1525, 1526)			UNCLASSIFIED	1020
3492	79870716 (1539, 1540)			UNCLASSIFIED	1010
3493	78268255 (1541, 1542)			UNCLASSIFIED	1024
3494	65502187 (1543, 1544)			UNCLASSIFIED	1014
3495	87111835 (1557, 1558)			UNCLASSIFIED	1005
3496	94324185 (1561, 1562)			UNCLASSIFIED	1008, 1026
3497	11102031 (1563, 1564)			UNCLASSIFIED	1004
3498	86472892 (1581, 1582)			UNCLASSIFIED	1026
3499	80221327 (1597, 1598)			UNCLASSIFIED	1000, 1008, 1021, 1027,
					1051
3500	46676949 (1603, 1604)			UNCLASSIFIED	1031
3501	77810466 (1609, 1610)			UNCLASSIFIED	1048
3502	70053099 (1613, 1614)			UNCLASSIFIED	1006
3503	25245470 (1643, 1644)			UNCLASSIFIED	1002
3504	86472610 (1657, 1658)			UNCLASSIFIED	1026
3505	57533365 (1661, 1662)			UNCLASSIFIED	1020, 1022
3506	21425891 (1663, 1664)			UNCLASSIFIED	1020
3507	37032526 (1667, 1668)			UNCLASSIFIED	1035
3508	80211645 (1677, 1678)			UNCLASSIFIED	1002, 1003, 1041
3509	79965421 (1679, 1680)			UNCLASSIFIED	1023
3510	85803482 (1685, 1686)			UNCLASSIFIED	1035
3511	78890140 (1691, 1692)			UNCLASSIFIED	1002
3512	46856760 (1697, 1698)			UNCLASSIFIED	1026
3513	17896078 (1699, 1700)			UNCLASSIFIED	1022
3514	71113036 (1703, 1704)			UNCLASSIFIED	1022
3515	25313328 (1711, 1712)			UNCLASSIFIED	1002
3516	79647472 (1719, 1720)			UNCLASSIFIED	1035, 1051
3517	79233766 (1725, 1726)			UNCLASSIFIED	1001, 1027
3518	65894261 (1743, 1744)			UNCLASSIFIED	1035
3519	78517619 (1745, 1746)			UNCLASSIFIED	1002
3520	35103654 (1747, 1748)			UNCLASSIFIED	1031
3521	15034723 (1749, 1750)			UNCLASSIFIED	1001
3522	91234953 (1753, 1754)			UNCLASSIFIED	1008
3523	78780894 (1761, 1762)			UNCLASSIFIED	1024
3524	54527322 (1777, 1778)			UNCLASSIFIED	1038
3525	86471698 (1785, 1786)			UNCLASSIFIED	1026
3526	86471898 (1787, 1788)			UNCLASSIFIED	1026
3527	16339805 (1789, 1790)			UNCLASSIFIED	1004
3528	20288566 (1803, 1804)			UNCLASSIFIED	1031
3529	19528620 (1817, 1818)			UNCLASSIFIED	1031
3530	21417734 (1827, 1828)			UNCLASSIFIED	1008
3531	20707160 (1829, 1830)			UNCLASSIFIED	1031
3532	78969555 (1835, 1836)			UNCLASSIFIED	1006, 1027
3533	33204480 (1837, 1838)			UNCLASSIFIED	1024
3534	32594339 (1845, 1846)			UNCLASSIFIED	1031
3535	79000057 (1851, 1852)			UNCLASSIFIED	1006, 1036, 1041
3536	80245704 (1873, 1874)			UNCLASSIFIED	1003, 1004, 1008, 1020,
					1022, 1026, 1031, 1037,
					1050
3537	80021840 (1897, 1898)			UNCLASSIFIED	1022
3538	6344649 (1905, 1906)			UNCLASSIFIED	1055
3539	10365642 (1911, 1912)			UNCLASSIFIED	1021
3540	79576319 (1913, 1914)			UNCLASSIFIED	1022
3541	78901994 (1923, 1924)			UNCLASSIFIED	1002
3542	34124779 (1941, 1942)			UNCLASSIFIED	1024
3543	39515024 (1951, 1952)			UNCLASSIFIED	1003
3544	36753955 (1955, 1956)			UNCLASSIFIED	1031
3545	78400559 (1961, 1962)			UNCLASSIFIED	1014, 1035
3546	65999502 (1965, 1966)			UNCLASSIFIED	1035
3547	70435185 (1967, 1968)			UNCLASSIFIED	1034
3548	16495691 (1979, 1980)			UNCLASSIFIED	1006
3549	78424546 (2005, 2006)			UNCLASSIFIED	1027
3550	13088889 (2007, 2008)			UNCLASSIFIED	1022
3551	20745150 (2019, 2020)			UNCLASSIFIED	1020
3552	78700930 (2029, 2030)			UNCLASSIFIED	1015
3553	50101893 (2031, 2032)			UNCLASSIFIED	1033
3554	79637678 (2043, 2044)			UNCLASSIFIED	1035
3555	78835952 (2045, 2046)			UNCLASSIFIED	1002
3556	25268638 (2049, 2050)			UNCLASSIFIED	1002
3557	78965178 (2059, 2060)			UNCLASSIFIED	1035
3558	47660075 (2061, 2062)			UNCLASSIFIED	1026
3559	77588768 (2063, 2064)			UNCLASSIFIED	1046
3560	27348381 (2069, 2070)			UNCLASSIFIED	1020
3561	71820957 (2071, 2072)			UNCLASSIFIED	1006
3562	94321408 (2075, 2076)			UNCLASSIFIED	1002
3563	40388961 (2099, 2100)			UNCLASSIFIED	1034
3564	80077640 (2107, 2108)			UNCLASSIFIED	1021, 1031
3565	19497683 (2123, 2124)			UNCLASSIFIED	1041
3566	65698339 (2127, 2128)			UNCLASSIFIED	1035
3567	80023430 (2143, 2144)			UNCLASSIFIED	1031
3568	66725795 (2145, 2146)			UNCLASSIFIED	1022
3569	20471498 (2147, 2148)			UNCLASSIFIED	1020
3570	23331040 (2155, 2156)			UNCLASSIFIED	1004
3571	16552632 (2159, 2160)			UNCLASSIFIED	1027
3572	46853123 (2193, 2194)			UNCLASSIFIED	1034
3573	54539457 (2197, 2198)			UNCLASSIFIED	1038
3574	55306950 (2203, 2204)			UNCLASSIFIED	1017
3575	77674116 (2209, 2210)			UNCLASSIFIED	1051
3576	54540370 (2213, 2214)			UNCLASSIFIED	1038
3577	25140270 (2217, 2218)			UNCLASSIFIED	1002
3578	79183020 (2227, 2228)			UNCLASSIFIED	1022
3579	80226712 (2229, 2230)			UNCLASSIFIED	1002, 1003
3580	80578671 (2233, 2234)			UNCLASSIFIED	1000, 1003, 1020, 1031,
					1005
3581	79427132 (2241, 2242)			UNCLASSIFIED	1015
3582	32124925 (2243, 2244)			UNCLASSIFIED	1004
3583	57922978 (2245, 2246)			UNCLASSIFIED	1032
3584	65468355 (2261, 2262)			UNCLASSIFIED	1051
3585	94675635 (2263, 2264)			UNCLASSIFIED	1028
3586	66255338 (2273, 2274)			UNCLASSIFIED	1035
3587	79246404 (2275, 2276)			UNCLASSIFIED	1036
3588	65465523 (2281, 2282)			UNCLASSIFIED	1035
3589	29497553 (2283, 2284)			UNCLASSIFIED	1007
3590	65506232 (2289, 2290)			UNCLASSIFIED	1014
3591	78157770 (2291, 2292)			UNCLASSIFIED	1026
3592	79618063 (2299, 2300)			UNCLASSIFIED	1002, 1015, 1020, 1022,
					1041
3593	17578951 (2307, 2308)			UNCLASSIFIED	1002
3594	10873638 (2309, 22310)			UNCLASSIFIED	1035
3595	8237944 (2315, 2316)			UNCLASSIFIED	1020
3596	46877462 (2319, 2320)			UNCLASSIFIED	1033
3597	30192098 (2323, 2324)			UNCLASSIFIED	1007
3598	46731026 (2333, 2334)			UNCLASSIFIED	1034
3599	57764132 (2335, 2336)			UNCLASSIFIED	1024, 1048
3600	35096121 (2343, 2344)			UNCLASSIFIED	1047
3601	86666401 (2351, 2352)			UNCLASSIFIED	1026
3602	1499122 (2355, 2356)			UNCLASSIFIED	1022
3603	94140988 (2361, 2362)			UNCLASSIFIED	1041
3604	78235983 (2369, 2370)			UNCLASSIFIED	1047
3605	99415891 (2371, 2372)			UNCLASSIFIED	1004, 1018
3606	78902302 (2375, 2376)			UNCLASSIFIED	1041
3607	86681344 (2383, 2384)			UNCLASSIFIED	1017
3608	79202243 (2385, 2386)			UNCLASSIFIED	1003
3609	46806955 (2389, 2390)			UNCLASSIFIED	1038
3610	32740192 (2393, 2394)			UNCLASSIFIED	1047
3611	16372470 (2395, 2396)			UNCLASSIFIED	1051
3612	91228291 (2405, 2406)			UNCLASSIFIED	1008
3613	91228399 (2407, 2408)			UNCLASSIFIED	1008
3614	52563483 (2413, 2414)			UNCLASSIFIED	1002
3615	52485072 (2417, 2418)			UNCLASSIFIED	1033
3616	65697481 (2431, 2432)			UNCLASSIFIED	1019, 1035
3617	78192673 (2435, 2436)			UNCLASSIFIED	1026
3618	39587464 (2457, 2458)			UNCLASSIFIED	1020
3619	65658841 (2461, 2462)			UNCLASSIFIED	1014, 1022, 1026, 1051
3620	11019628 (2471, 2472)			UNCLASSIFIED	1001
3621	46886993 (2477, 2478)			UNCLASSIFIED	1038
3622	71045449 (2479, 2480)			UNCLASSIFIED	1001, 1026, 1031
3623	86380160 (2483, 2484)			UNCLASSIFIED	1050
3624	79421125 (2485, 2486)			UNCLASSIFIED	1004
3625	28381776 (2493, 2494)			UNCLASSIFIED	1002, 1006
3626	78746032 (2495, 2496)			UNCLASSIFIED	1041
3627	78068597 (2523, 2524)			UNCLASSIFIED	1001
3628	79607546 (2533, 2534)			UNCLASSIFIED	1002, 1031, 1038, 1051
3629	30394319 (2553, 2554)			UNCLASSIFIED	1047
3630	47651920 (2555, 2556)			UNCLASSIFIED	1026
3631	20476250 (2565, 2566)			UNCLASSIFIED	1020
3632	34754593 (2567, 2568)			UNCLASSIFIED	1022
3633	78193010 (2573, 2574)			UNCLASSIFIED	1031
3634	39736987 (2583, 2584)			UNCLASSIFIED	1034
3635	30455830 (2585, 2586)			UNCLASSIFIED	1027
3636	81216486 (2603, 2604)			UNCLASSIFIED	1001, 1002, 1003, 1004
					1006, 1007, 1408, 1010
					1014, 1015, 1020, 1021
					1022, 1023, 1024, 1025
					1028, 1031, 1035, 1036
					1041, 1046, 1051
3637	77702253 (2609, 2610)			UNCLASSIFIED	1035
3638	49127631 (2615, 2616)			UNCLASSIFIED	1037
3639	9873274 (2623, 2624)			UNCLASSIFIED	1041
3640	78379444 (2629, 2630)			UNCLASSIFIED	1024
3641	80063267 (2633, 2634)			UNCLASSIFIED	1006, 1015, 1021, 1031
3642	80428354 (2635, 2636)			UNCLASSIFIED	1022, 1023, 1041
3643	35604627 (2637, 2638)			UNCLASSIFIED	1026
3644	86668031 (2645, 2646)			UNCLASSIFIED	1026
3645	65447043 (2653, 2654)			UNCLASSIFIED	1035
3646	55779287 (2655, 2656)			UNCLASSIFIED	1019
3647	30808157 (2663, 2664)			UNCLASSIFIED	1047
3648	80193155 (2675, 2676)			UNCLASSIFIED	1035, 1055
3649	79843527 (2677, 2678)			UNCLASSIFIED	1006
3650	46849653 (2683, 2684)			UNCLASSIFIED	1026
3651	29351909 (2685, 2686)			UNCLASSIFIED	1041
3652	87913234 (2691, 2692)			UNCLASSIFIED	1016, 1020
3653	27974005 (2697, 2698)			UNCLASSIFIED	1020
3654	78715780 (2719, 2720)			UNCLASSIFIED	1006, 1007, 1015, 1024
3655	78786371 (2729, 2730)			UNCLASSIFIED	1020
3656	66255506 (2739, 2740)			UNCLASSIFIED	1014
3657	57567671 (2745, 2746)			UNCLASSIFIED	1021
3658	16836431 (2749, 2750)			UNCLASSIFIED	1021
3659	80218369 (2765, 2766)			UNCLASSIFIED	1001, 1020, 1022
3660	37055937 (2767, 2768)			UNCLASSIFIED	1027
3661	19644342 (2769, 2770)			UNCLASSIFIED	1031
3662	25339900 (2787, 2788)			UNCLASSIFIED	1002
3663	78236643 (2789, 2790)			UNCLASSIFIED	1024
3664	34761626 (2797, 2798)			UNCLASSIFIED	1027
3665	78678904 (2807, 2808)			UNCLASSIFIED	1007
3666	20557833 (2809, 2810)			UNCLASSIFIED	1055
3667	94139859 (2813, 2814)			UNCLASSIFIED	1041
3668	65486699 (2815, 2816)			UNCLASSIFIED	1051
3669	80071788 (2819, 2820)			UNCLASSIFIED	1020
3670	77724257 (2823, 2824)			UNCLASSIFIED	1051
3671	79635735 (2825, 2826)			UNCLASSIFIED	1035
3672	55003597 (2827, 2828)			UNCLASSIFIED	1017
3673	51621004 (2829, 2830)			UNCLASSIFIED	1033
3674	71033720 (2831, 2832)			UNCLASSIFIED	1034, 1038
3675	34386965 (2833, 2834)			UNCLASSIFIED	1024
3676	80032829 (2837, 2838)			UNCLASSIFIED	1050
3677	79462591 (2851, 2852)			UNCLASSIFIED	1014, 1031
3678	78185398 (2859, 2860)			UNCLASSIFIED	1022, 1050
3679	80193829 (2861, 2862)			UNCLASSIFIED	1031, 1050, 1055
3680	80502697 (2873, 2874)			UNCLASSIFIED	1003, 1004, 1008, 1010
					1024, 1055
3681	28465931 (2875, 2876)			UNCLASSIFIED	1002
3682	29965879 (2877, 2878)			UNCLASSIFIED	1022
3683	27366914 (2881, 2882)			UNCLASSIFIED	1020
3684	50869757 (2901, 2902)			UNCLASSIFIED	1033
3685	79555889 (2907, 2908)			UNCLASSIFIED	1021
3686	79248537 (2909, 2910)			UNCLASSIFIED	1022
3687	66398017 (2911, 2912)			UNCLASSIFIED	1007
3688	79640057 (2917, 2918)			UNCLASSIFIED	1035
3689	54534082 (2923, 2924)			UNCLASSIFIED	1022, 1038
3690	54526857 (2935, 2936)			UNCLASSIFIED	1033
3691	21660945 (2939, 2940)			UNCLASSIFIED	1022
3692	36857751 (2945, 2946)			UNCLASSIFIED	1014
3693	55389743 (2949, 2950)			UNCLASSIFIED	1027
3694	46668352 (2953, 2954)			UNCLASSIFIED	1020
3695	34251001 (2961, 2962)			UNCLASSIFIED	1024
3696	11703373 (2967, 2968)			UNCLASSIFIED	1028
3697	46874237 (2973, 2974)			UNCLASSIFIED	1034
3698	37816708 (2975, 2976)			UNCLASSIFIED	1055
3699	35907210 (2981, 2982)			UNCLASSIFIED	1037
3700	78745265 (2983, 2984)			UNCLASSIFIED	1002, 1033
3701	79858904 (3007, 3008)			UNCLASSIFIED	1038
3702	78085425 (3009, 3010)			UNCLASSIFIED	1047
3703	78206639 (3017, 3018)			UNCLASSIFIED	1014
3704	65874974 (3021, 3022)			UNCLASSIFIED	1051
3705	28471465 (3023, 3024)			UNCLASSIFIED	1006
3706	78746666 (3037, 3038)			UNCLASSIFIED	1006
3707	46889682 (3047, 3048)			UNCLASSIFIED	1034
3708	78948378 (3057, 3058)			UNCLASSIFIED	1036
3709	66396594 (3065, 3066)			UNCLASSIFIED	1006, 1031
3710	78196786 (3067, 3068)			UNCLASSIFIED	1031
3711	16383784 (3071, 3072)			UNCLASSIFIED	1002
3712	47657734 (3077, 3078)			UNCLASSIFIED	1026
3713	79447045 (3105, 3106)			UNCLASSIFIED	1020
3714	33183407 (3109, 3110)			UNCLASSIFIED	1024
3715	86664985 (3115, 3116)			UNCLASSIFIED	1017, 1034
3716	10301850 (3119, 3120)			UNCLASSIFIED	1023
3717	79248020 (3125, 3126)			UNCLASSIFIED	1022
3718	35933247 (3127, 3128)			UNCLASSIFIED	1050
3719	99140168 (3141, 3142)			UNCLASSIFIED	1007, 1014, 1017, 1022,
					1051
3720	11694990 (3145, 3146)			UNCLASSIFIED	1035
3721	33694297 (3147, 3148)			UNCLASSIFIED	1024
3722	78953221 (3151, 3152)			UNCLASSIFIED	1014, 1027
3723	94326081 (3155, 3156)			UNCLASSIFIED	1041
3724	46742595 (3157, 3158)			UNCLASSIFIED	1030
3725	16426623 (3159, 3160)			UNCLASSIFIED	1051
3726	90993570 (3161, 3162)			UNCLASSIFIED	1018
3727	30661131 (3169, 3170)			UNCLASSIFIED	1020
3728	11175015 (3175, 3176)			UNCLASSIFIED	1003
3729	19885104 (3187, 3188)			UNCLASSIFIED	1001
3730	29694374 (3199, 3200)			UNCLASSIFIED	1024
3731	24143481 (3201, 3202)			UNCLASSIFIED	1002
3732	71101817 (3205, 3206)			UNCLASSIFIED	1022
3733	65656895 (3215, 3216)			UNCLASSIFIED	1035
3734	18436662 (3217, 3218)			UNCLASSIFIED	1031
3735	41672398 (3239, 3240)			UNCLASSIFIED	1034
3736	78052422 (3241, 3242)			UNCLASSIFIED	1034
3737	80183969 (3243, 3244)			UNCLASSIFIED	1019, 1020
3738	20476882 (3245, 3246)			UNCLASSIFIED	1020
3739	17895353 (3247, 3248)			UNCLASSIFIED	1002
3740	38905365 (3261, 3262)			UNCLASSIFIED	1014
3741	86685857 (3269, 3270)			UNCLASSIFIED	1026
3742	65468591 (3283, 3284)			UNCLASSIFIED	1051
3743	25131527 (3289, 3290)			UNCLASSIFIED	1002
3744	10094373 (3291, 3292)			UNCLASSIFIED	1015
3745	30505782 (3305, 3306)			UNCLASSIFIED	1006
3746	27836190 (3311, 3312)			UNCLASSIFIED	1004
3747	80423912 (3319, 3320)			UNCLASSIFIED	1001, 1002, 1003, 1004,
					1020, 1021, 1023, 1031,
					1036, 1041
3748	10249295 (3333, 3334)			UNCLASSIFIED	1035
3749	78680744 (3337, 3338)			UNCLASSIFIED	1002
3750	35103649 (3343, 3344)			UNCLASSIFIED	1031
3751	34899964 (3353, 3354)			UNCLASSIFIED	1051
3752	78360120 (3371, 3372)			UNCLASSIFIED	1006, 1024
3753	30632411 (3379, 3380)			UNCLASSIFIED	1006
3754	35024176 (3391, 3392)			UNCLASSIFIED	1051
3755	16457561 (3405, 3406)			UNCLASSIFIED	1035
3756	65645505 (3407, 3408)			UNCLASSIFIED	1038
3757	79798841 (3415, 3416)			UNCLASSIFIED	1002, 1006, 1021, 1036
3758	80203744 (3443, 3444)			UNCLASSIFIED	1014
3759	71750789 (3447, 3448)			UNCLASSIFIED	1002
3760	77802440 (3467, 3468)			UNCLASSIFIED	1022
3761	8359544 (3469, 3470)			UNCLASSIFIED	1003
3762	10225872 (3493, 3494)			UNCLASSIFIED	1036
3763	46894999 (3495, 3496)			UNCLASSIFIED	1039
3764	11389279 (3503, 3504)			UNCLASSIFIED	1022
3765	71045975 (3507, 3508)			UNCLASSIFIED	1034
3766	80087698 (3509, 3510)			UNCLASSIFIED	1008, 1051
3767	79579134 (3511, 3512)			UNCLASSIFIED	1004
3768	79919013 (3515, 3516)			UNCLASSIFIED	1021, 1050
3769	80066001 (3523, 3524)			UNCLASSIFIED	1004, 1008
3770	29646977 (3525, 3526)			UNCLASSIFIED	1022
3771	33188974 (3533, 3534)			UNCLASSIFIED	1024
3772	35009714 (3543, 3544)			UNCLASSIFIED	1031
3773	20467302 (3547, 3548)			UNCLASSIFIED	1008
3774	17931649 (3555, 3556)			UNCLASSIFIED	1002
3775	27361421 (3567, 3568)			UNCLASSIFIED	1021
3776	10299797 (3577, 3578)			UNCLASSIFIED	1035
3777	79557652 (3583, 3584)			UNCLASSIFIED	1035
3778	30169120 (3585, 3586)			UNCLASSIFIED	1035
3779	78374939 (3589, 3590)			UNCLASSIFIED	1002, 1015, 1021
3780	30787151 (3593, 3594)			UNCLASSIFIED	1024
3781	78804617 (3595, 3596)			UNCLASSIFIED	1027
3782	66367508 (3603, 3604)			UNCLASSIFIED	1050
3783	78373112 (3615, 3616)			UNCLASSIFIED	1015, 1022
3784	11413985 (3621, 3622)			UNCLASSIFIED	1015
3785	95009017 (3623, 3624)			UNCLASSIFIED	1002
3786	20723468 (3635, 3636)			UNCLASSIFIED	1022
3787	79816682 (3637, 3638)			UNCLASSIFIED	1015, 1035
3788	51577874 (3645, 3646)			UNCLASSIFIED	1033
3789	10846444 (3647, 3648)			UNCLASSIFIED	1001
3790	25260882 (3649, 3650)			UNCLASSIFIED	1002
3791	28389918 (3651, 3652)			UNCLASSIFIED	1051
3792	79318955 (3667, 3668)			UNCLASSIFIED	1031
3793	16283681 (3671, 3672)			UNCLASSIFIED	1022
3794	94138495 (3689, 3690)			UNCLASSIFIED	1002
3795	41672409 (3691, 3692)			UNCLASSIFIED	1034
3796	78836180 (3703, 3704)			UNCLASSIFIED	1006
3797	65659899 (3711, 3712)			UNCLASSIFIED	1051
3798	34112159 (3721, 3722)			UNCLASSIFIED	1026
3799	78956714 (3739, 3740)			UNCLASSIFIED	1036
3800	27842055 (3743, 3744)			UNCLASSIFIED	1020
3801	33187894 (3745, 3746)			UNCLASSIFIED	1024
3802	28001618 (3755, 3756)			UNCLASSIFIED	1051
3803	27967726 (3759, 3760)			UNCLASSIFIED	1050
3804	85546206 (3765, 3766)			UNCLASSIFIED	1014, 1017, 1051
3805	65475958 (3771, 3772)			UNCLASSIFIED	1035
3806	57118245 (3779, 3780)			UNCLASSIFIED	1051
3807	86474081 (3783, 3784)			UNCLASSIFIED	1051
3808	11618663 (3787, 3788)			UNCLASSIFIED	1022
3809	70118997 (3789, 3790)			UNCLASSIFIED	1007, 1014, 1041, 1051
3810	27980874 (3795, 3796)			UNCLASSIFIED	1004
3811	79242234 (3811, 3812)			UNCLASSIFIED	1021
3812	79959340 (3817, 3818)			UNCLASSIFIED	1015
3813	27824068 (3827, 3828)			UNCLASSIFIED	1022
3814	28822150 (3837, 3838)			UNCLASSIFIED	1015, 1031
3815	56660811 (3845, 3846)			UNCLASSIFIED	1039
3816	65661203 (3849, 3850)			UNCLASSIFIED	1038
3817	78490606 (3853, 3854)			UNCLASSIFIED	1027
3818	46849024 (3855, 3856)			UNCLASSIFIED	1034
3819	33202221 (3875, 3876)			UNCLASSIFIED	1024
3820	78678308 (3887, 3888)			UNCLASSIFIED	1020
3821	78725201 (3889, 3890)			UNCLASSIFIED	1006
3822	70624070 (3907, 3908)			UNCLASSIFIED	1033
3823	65643267 (3911, 3912)			UNCLASSIFIED	1014
3824	65469565 (3933, 3934)			UNCLASSIFIED	1035
3825	65655468 (3935, 3936)			UNCLASSIFIED	1022
3826	78914614 (3943, 3944)			UNCLASSIFIED	1051
3827	65896155 (3951, 3952)			UNCLASSIFIED	1006, 1051
3828	46772096 (3953, 3954)			UNCLASSIFIED	1031, 1034
3829	18596560 (3965, 3966)			UNCLASSIFIED	1035
3830	99389270 (3971, 3972)			UNCLASSIFIED	1008
3831	28348241 (3973, 3974)			UNCLASSIFIED	1022
3832	65891364 (3977, 3978)			UNCLASSIFIED	1051
3833	30152221 (4001, 4002)			UNCLASSIFIED	1035
3834	78492065 (4007, 4008)			UNCLASSIFIED	1027
3835	79642523 (4029, 4030)			UNCLASSIFIED	1035
3836	79861856 (4031, 4032)			UNCLASSIFIED	1035
3837	79871329 (4033, 4034)			UNCLASSIFIED	1036, 1041
3838	87890504 (4035, 4036)			UNCLASSIFIED	1013
3839	25242118 (4057, 4058)			UNCLASSIFIED	1041
3840	27968176 (4061, 4062)			UNCLASSIFIED	1004
3841	78784754 (4075, 4076)			UNCLASSIFIED	1007
3842	79408074 (4079, 4080)			UNCLASSIFIED	1014
3843	56333036 (4081, 4082)			UNCLASSIFIED	1043
3844	94239501 (4087, 4088)			UNCLASSIFIED	1008, 1022
3845	80026097 (4095, 4096)			UNCLASSIFIED	1022
3846	87456342 (4137, 4138)			UNCLASSIFIED	1023
3847	30198108 (4155, 4156)			UNCLASSIFIED	1024
3848	20710997 (4159, 4160)			UNCLASSIFIED	1004
3849	55402030 (4165, 4166)			UNCLASSIFIED	1017
3850	65465045 (4171, 4172)			UNCLASSIFIED	1035
3851	57458168 (4185, 4186)			UNCLASSIFIED	1051
3852	78728168 (4193, 4194)			UNCLASSIFIED	1015, 1017, 1019, 1022,
					1031, 1041, 1051
3853	13000688 (4207, 4208)			UNCLASSIFIED	1028
3854	80236710 (4211, 4212)			UNCLASSIFIED	1004, 1006
3855	17710366 (4221, 4222)			UNCLASSIFIED	1041
3856	20700094 (4223, 4224)			UNCLASSIFIED	1031
3857	80434504 (4227, 4228)			UNCLASSIFIED	1001, 1002, 1015, 1020,
					1035
3858	32711850 (4229, 4230)			UNCLASSIFIED	1026
3859	86672681 (4231, 4232)			UNCLASSIFIED	1045
3860	16842159 (4247, 4248)			UNCLASSIFIED	1002
3861	82391545 (4251, 4252)			UNCLASSIFIED	1001, 1015, 1036
3862	46907814 (4257, 4258)			UNCLASSIFIED	1051
3863	16543537 (4259, 4260)			UNCLASSIFIED	1041
3864	33694101 (4265, 4266)			UNCLASSIFIED	1024
3865	65668963 (4267, 4268)			UNCLASSIFIED	1014
3866	35018781 (4271, 4272)			UNCLASSIFIED	1031
3867	51234646 (4273, 4274)			UNCLASSIFIED	1033
3868	78732638 (4275, 4276)			UNCLASSIFIED	1024
3869	20449012 (4285, 4286)			UNCLASSIFIED	1020
3870	52563141 (4291, 4292)			UNCLASSIFIED	1020
3871	57764140 (4299, 4300)			UNCLASSIFIED	1048
3872	30817381 (4303, 4304)			UNCLASSIFIED	1041
3873	87114380 (4311, 4312)			UNCLASSIFIED	1023
3874	29686126 (4313, 4314)			UNCLASSIFIED	1035
3875	34098920 (4315, 4316)			UNCLASSIFIED	1022
3876	43152714 (4319, 4320)			UNCLASSIFIED	1001
3877	65883519 (4323, 4324)			UNCLASSIFIED	1051
3878	16836263 (4335, 4336)			UNCLASSIFIED	1021
3879	86475758 (4341, 4342)			UNCLASSIFIED	1045
3880	42943293 (4349, 4350)			UNCLASSIFIED	1001
3881	65882415 (4353, 4354)			UNCLASSIFIED	1051
3882	30420553 (4355, 4356)			UNCLASSIFIED	1022, 1051
3883	29347345 (4365, 4366)			UNCLASSIFIED	1006
3884	86679852 (4381, 4382)			UNCLASSIFIED	1005
3885	17110686 (4391, 4392)			UNCLASSIFIED	1027
3886	11103257 (4397, 4398)			UNCLASSIFIED	1020
3887	77544403 (4399, 4400)			UNCLASSIFIED	1014
3888	10173631 (4439, 4440)			UNCLASSIFIED	1021
3889	79847279 (4445, 4446)			UNCLASSIFIED	1036
3890	20621925 (4447, 4448)			UNCLASSIFIED	1003
3891	66442017 (4449, 4450)			UNCLASSIFIED	1004, 1010, 1020, 1021,
					1025, 1028, 1031
3892	25312469 (4459, 4460)			UNCLASSIFIED	1020
3893	79599936 (4469, 4470)			UNCLASSIFIED	1002
3894	65695299 (4477, 4478)			UNCLASSIFIED	1035
3895	78741111 (4479, 4480)			UNCLASSIFIED	1015
3896	91231091 (4483, 4484)			UNCLASSIFIED	1008
3897	65701383 (4485, 4486)			UNCLASSIFIED	1008
3898	11690101 (4487, 4488)			UNCLASSIFIED	1028
3899	28800584 (4489, 4490)			UNCLASSIFIED	1015
3900	11686830 (4503, 4504)			UNCLASSIFIED	1028
3901	54858787 (4513, 4514)			UNCLASSIFIED	1017
3902	78257578 (4521, 4522)			UNCLASSIFIED	1024
3903	77897196 (4525, 4526)			UNCLASSIFIED	1033
3904	13031713 (4527, 4528)			UNCLASSIFIED	1003
3905	87890824 (4531, 4532)			UNCLASSIFIED	1013
3906	79636785 (4535, 4536)			UNCLASSIFIED	1021
3907	15028427 (4541, 4542)			UNCLASSIFIED	1051
3908	65466325 (4547, 4548)			UNCLASSIFIED	1051
3909	42723088 (4551, 4552)			UNCLASSIFIED	1000
3910	10017074 (4555, 4556)			UNCLASSIFIED	1021
3911	71808623 (4557, 4558)			UNCLASSIFIED	1007, 1020
3912	66464838 (4569, 4570)			UNCLASSIFIED	1054
3913	19741094 (4575, 4576)			UNCLASSIFIED	1023
3914	3323644 (4593, 4594)			UNCLASSIFIED	1035
3915	79876205 (4595, 4596)			UNCLASSIFIED	1015
3916	65700316 (4609, 4610)			UNCLASSIFIED	1035
3917	29469285 (4675, 4676)			UNCLASSIFIED	1035
3918	28955148 (4697, 4698)			UNCLASSIFIED	1024
3919	79966209 (4705, 4706)			UNCLASSIFIED	1002, 1023
3920	79462800 (4709, 4710)			UNCLASSIFIED	1031
3921	10873043 (4713, 4714)			UNCLASSIFIED	1020
3922	9858716 (4715, 4716)			UNCLASSIFIED	1036
3923	85816681 (4721, 4722)			UNCLASSIFIED	1017
3924	80066607 (4723, 4724)			UNCLASSIFIED	1020
3925	86476727 (4729, 4730)			UNCLASSIFIED	1026
3926	90990455 (4733, 4734)			UNCLASSIFIED	1006, 1018, 1019, 1051,
					1055
3927	98421661 (4737, 4738)			UNCLASSIFIED	1000, 1002, 1006, 1008,
					1015, 1019, 1031, 1038
3928	28781284 (4753, 4754)			UNCLASSIFIED	1024
3929	38883229 (4763, 4764)			UNCLASSIFIED	1047, 1051
3930	78511398 (4775, 4776)			UNCLASSIFIED	1038, 1051
3931	79604903 (4783, 4784)			UNCLASSIFIED	1003
3932	35816017 (4791, 4792)			UNCLASSIFIED	1024
3933	51617480 (4793, 4794)			UNCLASSIFIED	1033
3934	77717021 (4801, 4802)			UNCLASSIFIED	1014
3935	40382597 (4823, 4824)			UNCLASSIFIED	1034
3936	78377539 (4825, 4826)			UNCLASSIFIED	1041
3937	46774743 (4829, 4830)			UNCLASSIFIED	1039
3938	65701385 (4833, 4834)			UNCLASSIFIED	1035
3939	11795701 (4835, 4836)			UNCLASSIFIED	1035
3940	16312090 (4837, 4838)			UNCLASSIFIED	1051
3941	9939777 (4845, 4846)			UNCLASSIFIED	1041
3942	79823597 (4857, 4858)			UNCLASSIFIED	1017, 1021, 1041, 1051
3943	78049817 (4861, 4862)			UNCLASSIFIED	1024
3944	33201780 (4863, 4864)			UNCLASSIFIED	1024
3945	10840687 (4891, 4892)			UNCLASSIFIED	1015
3946	27931141 (4895, 4896)			UNCLASSIFIED	1020
3947	78527897 (4903, 4904)			UNCLASSIFIED	1027
3948	78268274 (4915, 4916)			UNCLASSIFIED	1024
3949	46894060 (4919, 4920)			UNCLASSIFIED	1031
3950	79954324 (4921, 4922)			UNCLASSIFIED	1023
3951	65979550 (4927, 4928)			UNCLASSIFIED	1051
3952	80079455 (4931, 4932)			UNCLASSIFIED	1031
3953	54534093 (4937, 4938)			UNCLASSIFIED	1038
3954	20728393 (4939, 4940)			UNCLASSIFIED	1004
3955	55506019 (4941, 4942)			UNCLASSIFIED	1019
3956	78523668 (4943, 4944)			UNCLASSIFIED	1006, 1026
3957	71104557 (4947, 4948)			UNCLASSIFIED	1021
3958	20197541 (4955, 4956)			UNCLASSIFIED	1022
3959	56334712 (4959, 4960)			UNCLASSIFIED	1046
3960	55183444 (4977, 4978)			UNCLASSIFIED	1017
3961	70450451 (4979, 4980)			UNCLASSIFIED	1017
3962	66769028 (4985, 4986)			UNCLASSIFIED	1046
3963	78235359 (4993, 4994)			UNCLASSIFIED	1024
3964	16412431 (4995, 4996)			UNCLASSIFIED	1002
3965	28394457 (4997, 4998)			UNCLASSIFIED	1021
3966	30383089 (5013, 5014)			UNCLASSIFIED	1014
3967	66393613 (5025, 5026)			UNCLASSIFIED	1035
3968	34387080 (5029, 5030)			UNCLASSIFIED	1024
3969	24121590 (5039, 5040)			UNCLASSIFIED	1026
3970	32433483 (5041, 5042)			UNCLASSIFIED	1010
3971	94141717 (5045, 5046)			UNCLASSIFIED	1041
3972	25306744 (5055, 5056)			UNCLASSIFIED	1020
3973	88476858 (5057, 5058)			UNCLASSIFIED	1026
3974	78944624 (5059, 5060)			UNCLASSIFIED	1014
3975	65670632 (5061, 5062)			UNCLASSIFIED	1026
3976	13050562 (5073, 5074)			UNCLASSIFIED	1022
3977	27844300 (5085, 5086)			UNCLASSIFIED	1020
3978	39601978 (5089, 5090)			UNCLASSIFIED	1021
3979	65653559 (5093, 5094)			UNCLASSIFIED	1035
3980	80089370 (5099, 5100)			UNCLASSIFIED	1003, 1022, 1024
3981	54534284 (5101, 5102)			UNCLASSIFIED	1038
3982	33184707 (5105, 5106)			UNCLASSIFIED	1024
3983	79634511 (5107, 5108)			UNCLASSIFIED	1035
3984	86472313 (5113, 5114)			UNCLASSIFIED	1017
3985	20439571 (5121, 5122)			UNCLASSIFIED	1020
3986	33202592 (5133, 5134)			UNCLASSIFIED	1024
3987	79478434 (5135, 5136)			UNCLASSIFIED	1023
3988	79576204 (5141, 5142)			UNCLASSIFIED	1001, 1014, 1031, 1047,
					1050
3989	13522872 (5143, 5144)			UNCLASSIFIED	1001
3990	66049527 (5147, 5148)			UNCLASSIFIED	1005
3991	46848378 (5151, 5152)			UNCLASSIFIED	1026
3992	78956043 (5155, 5156)			UNCLASSIFIED	1006
3993	78305060 (5159, 5160)			UNCLASSIFIED	1024
3994	78380191 (5163, 5164)			UNCLASSIFIED	1024, 1050
3995	33189038 (5169, 5170)			UNCLASSIFIED	1024
3996	79573868 (5185, 5186)			UNCLASSIFIED	1001
3997	78317811 (5187, 5188)			UNCLASSIFIED	1011
3998	78505531 (5191, 5192)			UNCLASSIFIED	1020
3999	11798237 (5201, 5202)			UNCLASSIFIED	1031
4000	35128761 (5207, 5208)			UNCLASSIFIED	1010
4001	21433789 (5211, 5212)			UNCLASSIFIED	1020
4002	25177609 (5213, 5214)			UNCLASSIFIED	1003, 1004, 1021, 1031
4003	52563366 (5219, 5220)			UNCLASSIFIED	1002
4004	30620920 (5227, 5228)			UNCLASSIFIED	1020
4005	78825645 (5245, 5246)			UNCLASSIFIED	1027
4006	80421656 (5255, 5256)			UNCLASSIFIED	1001, 1003, 1006, 1020,
					1023, 1041
4007	55187397 (5257, 5258)			UNCLASSIFIED	1017
4008	77656677 (5271, 5272)			UNCLASSIFIED	1014, 1022
4009	65691308 (5291, 5292)			UNCLASSIFIED	1046
4010	27982125 (5293, 5294)			UNCLASSIFIED	1050
4011	54695036 (5295, 5296)			UNCLASSIFIED	1038
4012	79461884 (5313, 5314)			UNCLASSIFIED	1031
4013	80389472 (5317, 5318)			UNCLASSIFIED	1020, 1024, 1026
4014	30251469 (5319, 5320)			UNCLASSIFIED	1041
4015	13513007 (5329, 5330)			UNCLASSIFIED	1021, 1022
4016	56149302 (5333, 5334)			UNCLASSIFIED	1006
4017	78095920 (5355, 5356)			UNCLASSIFIED	1019
4018	46682434 (5365, 5366)			UNCLASSIFIED	1026
4019	46690837 (5375, 5376)			UNCLASSIFIED	1030
4020	12992450 (5377, 5378)			UNCLASSIFIED	1022
4021	87466194 (5383, 5384)			UNCLASSIFIED	1016
4022	39719598 (5387, 5388)			UNCLASSIFIED	1031
4023	55310055 (5389, 5390)			UNCLASSIFIED	1039
4024	33265615 (5393, 5394)			UNCLASSIFIED	1000
4025	65885491 (5401, 5402)			UNCLASSIFIED	1028
4026	32125784 (5421, 5422)			UNCLASSIFIED	1004
4027	52376941 (5425, 5426)			UNCLASSIFIED	1033
4028	33203507 (5431, 5432)			UNCLASSIFIED	1024
4029	78978467 (5435, 5436)			UNCLASSIFIED	1020, 1027, 1051
4030	11071319 (5443, 5444)			UNCLASSIFIED	1004
4031	65890822 (5451, 5452)			UNCLASSIFIED	1035
4032	29228414 (5469, 5470)			UNCLASSIFIED	1027
4033	79584929 (5483, 5484)			UNCLASSIFIED	1051
4034	66173703 (5497, 5498)			UNCLASSIFIED	1014
4035	65674710 (5509, 5510)			UNCLASSIFIED	1014
4036	85800185 (5513, 5514)			UNCLASSIFIED	1023
4037	78670351 (5535, 5536)			UNCLASSIFIED	1024
4038	10847716 (5539, 5540)			UNCLASSIFIED	1001
4039	35144239 (5541, 5542)			UNCLASSIFIED	1047
4040	6331065 (5581, 5562)			UNCLASSIFIED	1055
4041	30235029 (5563, 5564)			UNCLASSIFIED	1026
4042	94147686 (5569, 5570)			UNCLASSIFIED	1041
4043	80225256 (5573, 5574)			UNCLASSIFIED	1020
4044	94239307 (5581, 5582)			UNCLASSIFIED	1023
4045	58213698 (5599, 5600)			UNCLASSIFIED	1020
4046	65987181 (5601, 5602)			UNCLASSIFIED	1051
4047	20554815 (5603, 5604)			UNCLASSIFIED	1050
4048	80080228 (5619, 5620)			UNCLASSIFIED	1020
4049	65655872 (5625, 5626)			UNCLASSIFIED	1051
4050	78046862 (5631, 5632)			UNCLASSIFIED	1024
4051	19740737 (5637, 5638)			UNCLASSIFIED	1002
4052	79265109 (5643, 5644)			UNCLASSIFIED	1005
4053	25136397 (5647, 5648)			UNCLASSIFIED	1002
4054	65458428 (5657, 5658)			UNCLASSIFIED	1051
4055	78303052 (5665, 5666)			UNCLASSIFIED	1024
4056	66139535 (5669, 5670)			UNCLASSIFIED	1003
4057	11615647 (5673, 5674)			UNCLASSIFIED	1004
4058	78487206 (5675, 5676)			UNCLASSIFIED	1024
4059	13032587 (5677, 5678)			UNCLASSIFIED	1022
4060	78390333 (5683, 5684)			UNCLASSIFIED	1020
4061	54540020 (5699, 5700)			UNCLASSIFIED	1038
4062	94234536 (5703, 5704)			UNCLASSIFIED	1002
4063	14996436 (5711, 5712)			UNCLASSIFIED	1022
4064	95420776 (5723, 5724)			UNCLASSIFIED	1051
4065	57056645 (5727, 5728)			UNCLASSIFIED	1051
4066	30817392 (5735, 5736)			UNCLASSIFIED	1041
4067	94747080 (5739, 5740)			UNCLASSIFIED	1002, 1007, 1020, 1031,
					1034, 1035, 1041
4068	78254479 (5741, 5742)			UNCLASSIFIED	1024
4069	12806365 (5753, 5754)			UNCLASSIFIED	1003
4070	28307526 (5757, 5758)			UNCLASSIFIED	1051
4071	66556800 (5771, 5772)			UNCLASSIFIED	1007
4072	20288127 (5775, 5776)			UNCLASSIFIED	1031
4073	78470896 (5777, 5778)			UNCLASSIFIED	1050
4074	91220019 (5785, 5786)			UNCLASSIFIED	1041
4075	80062075 (5793, 5794)			UNCLASSIFIED	1020, 1035
4076	66256460 (5797, 5798)			UNCLASSIFIED	1014
4077	33200626 (5801, 5802)			UNCLASSIFIED	1024
4078	25250044 (5807, 5808)			UNCLASSIFIED	1041
4079	10887065 (5817, 5818)			UNCLASSIFIED	1025
4080	85803373 (5825, 5826)			UNCLASSIFIED	1051
4081	65697321 (5831, 5832)			UNCLASSIFIED	1035
4082	80047922 (5847, 5848)			UNCLASSIFIED	1020, 1023, 1051
4083	65651292 (5855, 5856)			UNCLASSIFIED	1051
4084	80034763 (5861, 5862)			UNCLASSIFIED	1050
4085	13070491 (5863, 5864)			UNCLASSIFIED	1022
4086	46906764 (5885, 5886)			UNCLASSIFIED	1037
4087	79814725 (5893, 5894)			UNCLASSIFIED	1015, 1023, 1035
4088	36840458 (5895, 5896)			UNCLASSIFIED	1051
4089	20633617 (5897, 5898)			UNCLASSIFIED	1031
4090	78519782 (5899, 5900)			UNCLASSIFIED	1041
4091	17565583 (5903, 5904)			UNCLASSIFIED	1002
4092	78901767 (5915, 5916)			UNCLASSIFIED	1022, 1036
4093	11699215 (5919, 5920)			UNCLASSIFIED	1028
4094	66171743 (5923, 5924)			UNCLASSIFIED	1029, 1035
4095	66582653 (5947, 5948)			UNCLASSIFIED	1007
4096	79910954 (5973, 5974)			UNCLASSIFIED	1041
4097	80076243 (5975, 5976)			UNCLASSIFIED	1020
4098	78985005 (5977, 5978)			UNCLASSIFIED	1027
4099	91009475 (5985, 5986)			UNCLASSIFIED	1018
4100	78901768 (6001, 6002)			UNCLASSIFIED	1036
4101	11087950 (6003, 6004)			UNCLASSIFIED	1020
4102	77681934 (6007,6008)			UNCLASSIFIED	1014
4103	95292964 (6019, 6020)			UNCLASSIFIED	1008
4104	80073933 (6021, 6022)			UNCLASSIFIED	1022
4105	80431947 (6027, 6028)			UNCLASSIFIED	1002, 1007, 1035, 1041
4106	79624651 (6039, 6040)			UNCLASSIFIED	1021
4107	80234432 (6047, 6048)			UNCLASSIFIED	1001, 1004, 1010, 1020,
					1022, 1024, 1028, 1031
4108	79206096 (6049, 6050)			UNCLASSIFIED	1031
4109	30817005 (6059, 6060)			UNCLASSIFIED	1041
4110	29242793 (6061, 6062)			UNCLASSIFIED	1006
4111	35009979 (6065, 6066)			UNCLASSIFIED	1035
4112	87122142 (6067, 6068)			UNCLASSIFIED	1023
4113	91009929 (6071, 6072)			UNCLASSIFIED	1018
4114	79623479 (6073, 6074)			UNCLASSIFIED	1001
4115	11398414 (6079, 6080)			UNCLASSIFIED	1004
4116	65703325 (6087, 6088)			UNCLASSIFIED	1035
4117	65684346 (6093, 6094)			UNCLASSIFIED	1046, 1055
4118	10868901 (6103, 6104)			UNCLASSIFIED	1004
4119	11311378 (6105, 6106)			UNCLASSIFIED	1020
4120	79235267 (6113, 6114)			UNCLASSIFIED	1006
4121	30152838 (6117, 6118)			UNCLASSIFIED	1035
4122	20711416 (6129, 6130)			UNCLASSIFIED	1004
4123	17678565 (6131, 6132)			UNCLASSIFIED	1006
4124	36988726 (6133, 6134)			UNCLASSIFIED	1014
4125	78918057 (6137, 6138)			UNCLASSIFIED	1036
4126	77817414 (6155, 6156)			UNCLASSIFIED	1020
4127	65697328 (6167, 6168)			UNCLASSIFIED	1035
4128	78053726 (6175, 6176)			UNCLASSIFIED	1024
4129	46671323 (6177, 6178)			UNCLASSIFIED	1020
4130	65883859 (6179, 6180)			UNCLASSIFIED	1035
4131	87118463 (6181, 6182)			UNCLASSIFIED	1022, 1023
4132	18470878 (6195, 6196)			UNCLASSIFIED	1031
4133	65969432 (6197, 6198)			UNCLASSIFIED	1050
4134	87453791 (6199, 6200)			UNCLASSIFIED	1023
4135	56513556 (6201, 6202)			UNCLASSIFIED	1017
4136	16326912 (6213, 6214)			UNCLASSIFIED	1031
4137	16550020 (6229, 6230)			UNCLASSIFIED	1027
4138	79611588 (6239, 6240)			UNCLASSIFIED	1036
4139	78066806 (6247, 6248)			UNCLASSIFIED	1031, 1047
4140	34081193 (6251, 6252)			UNCLASSIFIED	1000
4141	46899384 (6255, 6256)			UNCLASSIFIED	1038
4142	79758123 (6259, 6260)			UNCLASSIFIED	1006, 1015
4143	11357965 (6265, 6266)			UNCLASSIFIED	1055
4144	9285363 (6273, 6274)			UNCLASSIFIED	1006, 1008
4145	46665971 (6279, 6280)			UNCLASSIFIED	1020
4146	78407155 (6283, 6284)			UNCLASSIFIED	1022, 1033, 1038
4147	20621931 (6295, 6296)			UNCLASSIFIED	1003
4148	10169149 (6297, 6298)			UNCLASSIFIED	1023
4149	11693024 (6299, 6300)			UNCLASSIFIED	1031
4150	27972796 (6309, 6310)			UNCLASSIFIED	1004
4151	16456669 (6321, 6322)			UNCLASSIFIED	1006
4152	94740044 (6333, 6334)			UNCLASSIFIED	1041
4153	65656730 (6337, 6338)			UNCLASSIFIED	1035
4154	27842096 (6341, 6342)			UNCLASSIFIED	1020
4155	80034769 (6355, 6356)			UNCLASSIFIED	1050
4156	78708420 (6361, 6362)			UNCLASSIFIED	1007, 1015, 1019, 1033,
					1051
4157	78742567 (6367, 6368)			UNCLASSIFIED	1051
4158	66041756 (6375, 6376)			UNCLASSIFIED	1014, 1027, 1051
4159	95314292 (6377, 6378)			UNCLASSIFIED	1008
4160	27980005 (6383, 6384)			UNCLASSIFIED	1020
4161	95007160 (6385, 6386)			UNCLASSIFIED	1022, 1031, 1051
4162	46869941 (6397, 6398)			UNCLASSIFIED	1034
4163	34102245 (6399, 6400)			UNCLASSIFIED	1022
4164	79445277 (6401, 6402)			UNCLASSIFIED	1022
4165	33183198 (6403, 6404)			UNCLASSIFIED	1024
4166	18536627 (6429, 6430)			UNCLASSIFIED	1015
4167	94701911 (6431, 6432)			UNCLASSIFIED	1008
4168	70101159 (6463, 6464)			UNCLASSIFIED	1017
4169	66037530 (6469, 6470)			UNCLASSIFIED	1029
4170	42723069 (6477, 6478)			UNCLASSIFIED	1000
4171	79607920 (6489, 6490)			UNCLASSIFIED	1001
4172	86664798 (6493, 6494)			UNCLASSIFIED	1017
4173	65445071 (6495, 6496)			UNCLASSIFIED	1035
4174	12904360 (6497, 6498)			UNCLASSIFIED	1028, 1047
4175	27983938 (6523, 6524)			UNCLASSIFIED	1014
4176	33043643 (6525, 6526)			UNCLASSIFIED	1000
4177	9671885 (6539, 6540)			UNCLASSIFIED	1021
4178	100090708 (6549, 6550)			UNCLASSIFIED	1002, 1004, 1010, 1043
4179	30256515 (6555, 6556)			UNCLASSIFIED	1041
4180	1782112 (6559, 6560)			UNCLASSIFIED	1036
4181	27968065 (6561, 6562)			UNCLASSIFIED	1004
4182	27847852 (6587, 6588)			UNCLASSIFIED	1004
4183	78673470 (6593, 6594)			UNCLASSIFIED	1024
4184	57057071 (6597, 6598)			UNCLASSIFIED	1051
4185	28832464 (6611, 6612)			UNCLASSIFIED	1015
4186	11305369 (6617, 6618)			UNCLASSIFIED	1020
4187	17942349 (6621, 6622)			UNCLASSIFIED	1036
4188	80197597 (6633, 6634)			UNCLASSIFIED	1003, 1004, 1031
4189	16796894 (6641, 6642)			UNCLASSIFIED	1041
4190	43337302 (6643, 6644)			UNCLASSIFIED	1034
4191	27974626 (6645, 6646)			UNCLASSIFIED	1003
4192	33204353 (6649, 6650)			UNCLASSIFIED	1024
4193	23294699 (6655, 6656)			UNCLASSIFIED	1021
4194	71033741 (6667, 6668)			UNCLASSIFIED	1033, 1038
4195	33189538 (6671, 6672)			UNCLASSIFIED	1024
4196	77654576 (6673, 6674)			UNCLASSIFIED	1003
4197	19518170 (6679, 6680)			UNCLASSIFIED	1002, 1021
4198	80085851 (6681, 6682)			UNCLASSIFIED	1051
4199	91232516 (6691, 6692)			UNCLASSIFIED	1008
4200	20414027 (6699, 6700)			UNCLASSIFIED	1008
4201	10314264 (6703, 6704)			UNCLASSIFIED	1023
4202	33202236 (6705, 6706)			UNCLASSIFIED	1024
4203	80076441 (6707, 6708)			UNCLASSIFIED	1014
4204	78279405 (6709, 6710)			UNCLASSIFIED	1010, 1041
4205	78061916 (6735, 6736)			UNCLASSIFIED	1001
4206	79776991 (6743, 6744)			UNCLASSIFIED	1006
4207	79567978 (6751, 6752)			UNCLASSIFIED	1015
4208	27846532 (6753, 6754)			UNCLASSIFIED	1003, 1004
4209	10871598 (6757, 6758)			UNCLASSIFIED	1004
4210	66141239 (6769, 6770)			UNCLASSIFIED	1022
4211	16313560 (6771, 6772)			UNCLASSIFIED	1051
4212	27372041 (6773, 6774)			UNCLASSIFIED	1024
4213	16315152 (6777, 6778)			UNCLASSIFIED	1051
4214	79427073 (6781, 6782)			UNCLASSIFIED	1015
4215	25254641 (6807, 6808)			UNCLASSIFIED	1006
4216	79110357 (6831, 6832)			UNCLASSIFIED	1006, 1014, 1041
4217	49514230 (6843, 6844)			UNCLASSIFIED	1033
4218	30256268 (6845, 6846)			UNCLASSIFIED	1022
4219	80504315 (6851, 6852)			UNCLASSIFIED	1002, 1010, 1021
4220	85527269 (6853, 6854)			UNCLASSIFIED	1035
4221	86476282 (6855, 6856)			UNCLASSIFIED	1026
4222	87114392 (6863, 6864)			UNCLASSIFIED	1023
4223	79578263 (6865, 6866)			UNCLASSIFIED	1002, 1004, 1006, 1007,
					1015, 1036
4224	80248910 (6871, 6872)			UNCLASSIFIED	1002, 1003, 1004, 1007,
					1020, 1041
4225	28999996 (6877, 6878)			UNCLASSIFIED	1041
4226	21436936 (6907, 6908)			UNCLASSIFIED	1003
4227	80079467 (6913, 6914)			UNCLASSIFIED	1031
4228	20615850 (6923, 6924)			UNCLASSIFIED	1022
4229	18519374 (6925, 6926)			UNCLASSIFIED	1001
4230	78250641 (6927, 6928)			UNCLASSIFIED	1026
4231	37026242 (6935, 6936)			UNCLASSIFIED	1035
4232	94323474 (6947, 6948)			UNCLASSIFIED	1051
4233	39710205 (6953, 6954)			UNCLASSIFIED	1006
4234	32357717 (6955, 6956)			UNCLASSIFIED	1051
4235	57107512 (6957, 6958)			UNCLASSIFIED	1004, 1015, 1020, 1022
4236	78956408 (6969, 6970)			UNCLASSIFIED	1027
4237	52470405 (6971, 6972)			UNCLASSIFIED	1033
4238	66599197 (6975, 6976)			UNCLASSIFIED	1051
4239	78161421 (6979, 6980)			UNCLASSIFIED	1022
4240	78780340 (7023, 7024)			UNCLASSIFIED	1020, 1024
4241	55501079 (7029, 7030)			UNCLASSIFIED	1019
4242	78713891 (7031, 7032)			UNCLASSIFIED	1027
4243	20286180 (7051, 7052)			UNCLASSIFIED	1020
4244	36524048 (7053, 7054)			UNCLASSIFIED	1017
4245	79610849 (7055, 7056)			UNCLASSIFIED	1022
4246	78759335 (7063, 7064)			UNCLASSIFIED	1036
4247	78298406 (7067, 7068)			UNCLASSIFIED	1024
4248	10159288 (7073, 7074)			UNCLASSIFIED	1002
4249	50876921 (7083, 7084)			UNCLASSIFIED	1033
4250	20293635 (7087, 7088)			UNCLASSIFIED	1004
4251	66248710 (7089, 7090)			UNCLASSIFIED	1050
4252	78107270 (7103, 7104)			UNCLASSIFIED	1033
4253	30540740 (7109, 7110)			UNCLASSIFIED	1024
4254	78248505 (7113, 7114)			UNCLASSIFIED	1027
4255	78735474 (7117, 7118)			UNCLASSIFIED	1041
4256	71113067 (7123, 7124)			UNCLASSIFIED	1022
4257	30804412 (7131, 7132)			UNCLASSIFIED	1026
4258	94670373 (7137, 7138)			UNCLASSIFIED	1004
4259	77783861 (7141, 7142)			UNCLASSIFIED	1017
4260	71047276 (7155, 7156)			UNCLASSIFIED	1022, 1024, 1036
4261	80255888 (7157, 7158)			UNCLASSIFIED	1008
4262	34882072 (7171, 7172)			UNCLASSIFIED	1026
4263	66727380 (7173, 7174)			UNCLASSIFIED	1046
4264	17960962 (7177, 7178)			UNCLASSIFIED	1036
4265	27923405 (7179, 7180)			UNCLASSIFIED	1004
4266	79834165 (7183, 7184)			UNCLASSIFIED	1006
4267	38454471 (7187, 7188)			UNCLASSIFIED	1051
4268	30401770 (7191, 7192)			UNCLASSIFIED	1024
4269	34892989 (7193, 7194)			UNCLASSIFIED	1047
4270	80258520 (7201, 7202)			UNCLASSIFIED	1008, 1051
4271	85539894 (7207, 7208)			UNCLASSIFIED	1035
4272	20608203 (7215, 7216)			UNCLASSIFIED	1003
4273	65473568 (7231, 7232)			UNCLASSIFIED	1051
4274	66363828 (7233, 7234)			UNCLASSIFIED	1003
4275	77666363 (7243, 7244)			UNCLASSIFIED	1050
4276	87457794 (7245, 7246)			UNCLASSIFIED	1016
4277	65479067 (7249, 7250)			UNCLASSIFIED	1035
4278	85822954 (7259, 7260)			UNCLASSIFIED	1045
4279	77530644 (7271, 7272)			UNCLASSIFIED	1035
4280	35131206 (7277, 7278)			UNCLASSIFIED	1000
4281	65896777 (7279, 7280)			UNCLASSIFIED	1051
4282	78960096 (7281, 7282)			UNCLASSIFIED	1006, 1027
4283	55405441 (7291, 7292)			UNCLASSIFIED	1039
4284	78741397 (7293, 7294)			UNCLASSIFIED	1041
4285	80098140 (7301, 7302)			UNCLASSIFIED	1003, 1022, 1023
4286	91231570 (7305, 7306)			UNCLASSIFIED	1002
4287	78477787 (7309, 7310)			UNCLASSIFIED	1006
4288	78317357 (7323, 7324)			UNCLASSIFIED	1024
4289	78781762 (7331, 7332)			UNCLASSIFIED	1020
4290	54698166 (7335, 7336)			UNCLASSIFIED	1038
4291	52571364 (7363, 7364)			UNCLASSIFIED	1033
4292	66143816 (7365, 7366)			UNCLASSIFIED	1008, 1039
4293	94321654 (7367, 7368)			UNCLASSIFIED	1001, 1002, 1010, 1031,
					1051
4294	78792119 (7369, 7370)			UNCLASSIFIED	1014, 1015, 1036
4295	94323443 (7371, 7372)			UNCLASSIFIED	1051
4296	78297939 (7375, 7376)			UNCLASSIFIED	1027
4297	79974047 (7413, 7414)			UNCLASSIFIED	1021
4298	8910196 (7439, 7440)			UNCLASSIFIED	1021
4299	79572191 (7441, 7442)			UNCLASSIFIED	1001
4300	80048876 (7445, 7446)			UNCLASSIFIED	1003, 1051
4301	25146376 (7461, 7462)			UNCLASSIFIED	1036
4302	11793419 (7465, 7466)			UNCLASSIFIED	1023
4303	71208240 (7471, 7472)			UNCLASSIFIED	1017, 1047
4304	54695984 (7475, 7476)			UNCLASSIFIED	1037
4305	33183803 (7483, 7484)			UNCLASSIFIED	1024
4306	91012461 (7485, 7486)			UNCLASSIFIED	1008
4307	78049832 (7503, 7504)			UNCLASSIFIED	1024
4308	78394868 (7515, 7516)			UNCLASSIFIED	1035
4309	78388490 (7517, 7518)			UNCLASSIFIED	1024
4310	11798792 (7531, 7532)			UNCLASSIFIED	1014
4311	33188480 (7535, 7536)			UNCLASSIFIED	1024
4312	14154923 (7557, 7558)			UNCLASSIFIED	1014
4313	34667105 (7561, 7562)			UNCLASSIFIED	1026
4314	19641442 (7569, 7570)			UNCLASSIFIED	1022
4315	30392015 (7571, 7572)			UNCLASSIFIED	1027
4316	54696369 (7589, 7590)			UNCLASSIFIED	1038
4317	80412988 (7613, 7614)			UNCLASSIFIED	1026
4318	29342366 (7621, 7622)			UNCLASSIFIED	1007
4319	81821520 (7631, 7632)			UNCLASSIFIED	1051
4320	11811365 (7633, 7634)			UNCLASSIFIED	1035
4321	8522062 (7635, 7636)			UNCLASSIFIED	1031
4322	79246951 (7639, 7640)			UNCLASSIFIED	1002
4323	11395060 (7641, 7642)			UNCLASSIFIED	1031
4324	79569085 (7649, 7650)			UNCLASSIFIED	1015
4325	30519422 (7653, 7654)			UNCLASSIFIED	1022
4326	29687932 (7663, 7664)			UNCLASSIFIED	1014
4327	30158321 (7669, 7670)			UNCLASSIFIED	1026
4328	81742754 (7671, 7672)			UNCLASSIFIED	1051
4329	91226597 (7673, 7674)			UNCLASSIFIED	1003, 1008
4330	32425855 (7681, 7682)			UNCLASSIFIED	1026
4331	13086608 (7687, 7688)			UNCLASSIFIED	1022
4332	28794345 (7693, 7694)			UNCLASSIFIED	1041
4333	71795370 (7697, 7698)			UNCLASSIFIED	1006, 1007
4334	78794094 (7703, 7704)			UNCLASSIFIED	1007
4335	66155711 (7707, 7708)			UNCLASSIFIED	1002, 1003
4336	11617467 (7719, 7720)			UNCLASSIFIED	1003
4337	51728410 (7733, 7734)			UNCLASSIFIED	1037
4338	78757399 (7735, 7736)			UNCLASSIFIED	1041
4339	65504987 (7741, 7742)			UNCLASSIFIED	1035
4340	27262716 (7749, 7750)			UNCLASSIFIED	1015
4341	77731440 (7753, 7754)			UNCLASSIFIED	1043
4342	78101975 (7761, 7762)			UNCLASSIFIED	1052
4343	38194650 (7773, 7774)			UNCLASSIFIED	1027
4344	87454805 (7777, 7778)			UNCLASSIFIED	1023
4345	80581048 (7779, 7780)			UNCLASSIFIED	1002, 1003, 1004, 1006,
					1007, 1008, 1015, 1020,
					1022, 1028, 1031, 1055
4346	35092915 (7781, 7782)			UNCLASSIFIED	1047
4347	54701303 (7783, 7784)			UNCLASSIFIED	1017
4348	80221827 (7787, 7788)			UNCLASSIFIED	1014
4349	10131687 (7793, 7794)			UNCLASSIFIED	1041
4350	16525372 (7801, 7802)			UNCLASSIFIED	1027
4351	78188445 (7809, 7810)			UNCLASSIFIED	1026
4352	56067857 (7811, 7812)			UNCLASSIFIED	1019
4353	34126419 (7813, 7814)			UNCLASSIFIED	1024
4354	70567845 (7815, 7816)			UNCLASSIFIED	1002, 1003, 1033, 1041
4355	55764343 (7823, 7824)			UNCLASSIFIED	1021, 1033
4356	65702063 (7831, 7832)			UNCLASSIFIED	1035
4357	80046692 (7833, 7834)			UNCLASSIFIED	1022, 1038
4358	65878255 (7837, 7838)			UNCLASSIFIED	1041
4359	94135090 (7841, 7842)			UNCLASSIFIED	1008
4360	71466509 (7843, 7844)			UNCLASSIFIED	1017, 1024
4361	20434291 (7861, 7862)			UNCLASSIFIED	1003
4362	17710858 (7863, 7864)			UNCLASSIFIED	1015
4363	55183282 (7869, 7870)			UNCLASSIFIED	1039
4364	17139933 (7873, 7874)			UNCLASSIFIED	1036
4365	65879441 (7877, 7878)			UNCLASSIFIED	1014
4366	80149654 (7885, 7886)			UNCLASSIFIED	1008, 1055
4367	37055375 (7897, 7898)			UNCLASSIFIED	1027
4368	27356015 (7907, 7908)			UNCLASSIFIED	1024
4369	79310489 (7909, 7910)			UNCLASSIFIED	1022
4370	95287836 (7917, 7918)			UNCLASSIFIED	1006, 1010, 1015, 1051
4371	78254487 (7921, 7922)			UNCLASSIFIED	1024
4372	30817986 (7931, 7932)			UNCLASSIFIED	1024
4373	78297979 (7935, 7936)			UNCLASSIFIED	1027
4374	66368983 (7943, 7944)			UNCLASSIFIED	1051
4375	90937494 (7955, 7956)			UNCLASSIFIED	1018
4376	78161920 (7959, 7960)			UNCLASSIFIED	1000
4377	71297578 (7961, 7962)			UNCLASSIFIED	1000, 1001, 1022
4378	78490285 (7971, 7972)			UNCLASSIFIED	1027
4379	13089767 (7979, 7980)			UNCLASSIFIED	1025
4380	5637866 (7987, 7988)			UNCLASSIFIED	1055
4381	32122983 (7995, 7996)			UNCLASSIFIED	1022
4382	78928374 (8013, 8014)			UNCLASSIFIED	1015
4383	77712820 (8021, 8022)			UNCLASSIFIED	1051
4384	95102078 (8023, 8024)			UNCLASSIFIED	1041
4385	66312467 (8041, 8042)			UNCLASSIFIED	1051
4386	80060621 (8047, 8048)			UNCLASSIFIED	1022, 1036
4387	71091125 (8053, 8054)			UNCLASSIFIED	1005, 1031, 1046
4388	79419209 (8071, 8072)			UNCLASSIFIED	1008
4389	32283895 (8083, 8084)			UNCLASSIFIED	1047
4390	54533422 (8091, 8092)			UNCLASSIFIED	1038
4391	77544426 (8095, 8096)			UNCLASSIFIED	1014
4392	78980649 (8105, 8106)			UNCLASSIFIED	1022
4393	38069803 (8107, 8108)			UNCLASSIFIED	1033
4394	9844352 (8115, 8116)			UNCLASSIFIED	1021
4395	78490286 (8121, 8122)			UNCLASSIFIED	1027
4396	34867899 (8123, 8124)			UNCLASSIFIED	1047
4397	79200648 (8135, 8136)			UNCLASSIFIED	1003, 1022, 1025, 1031
4398	35070432 (8139, 8140)			UNCLASSIFIED	1027
4399	66465809 (8143, 8144)			UNCLASSIFIED	1022
4400	27962501 (8145, 8146)			UNCLASSIFIED	1020
4401	10302827 (8147, 8148)			UNCLASSIFIED	1036
4402	55004194 (8149, 8150)			UNCLASSIFIED	1017
4403	80254666 (8161, 8162)			UNCLASSIFIED	1003
4404	78952408 (8167, 8168)			UNCLASSIFIED	1002
4405	19510208 (8169, 8170)			UNCLASSIFIED	1031
4406	78462199 (8185, 8186)			UNCLASSIFIED	1002, 1051
4407	78188298 (8187, 8188)			UNCLASSIFIED	1026
4408	80104525 (8191, 8192)			UNCLASSIFIED	1002, 1004, 1022, 1051
4409	79835167 (8209, 8210)			UNCLASSIFIED	1006
4410	94326068 (8213, 8214)			UNCLASSIFIED	1041
4411	25140679 (8223, 8224)			UNCLASSIFIED	1002
4412	78924391 (8225, 8226)			UNCLASSIFIED	1000, 1024, 1026, 1051
4413	78674480 (8229, 8230)			UNCLASSIFIED	1007, 1051
4414	18520847 (8251, 8252)			UNCLASSIFIED	1015
4415	79641282 (8253, 8254)			UNCLASSIFIED	1035
4416	10872492 (8255, 8256)			UNCLASSIFIED	1020
4417	46788868 (8263, 8264)			UNCLASSIFIED	1037
4418	20456670 (8267, 8268)			UNCLASSIFIED	1008
4419	66437272 (8271, 8272)			UNCLASSIFIED	1022
4420	46683894 (8275, 8276)			UNCLASSIFIED	1020
4421	82125380 (8279, 8280)			UNCLASSIFIED	1014
4422	80054024 (8283, 8284)			UNCLASSIFIED	1003
4423	91255717 (8285, 8286)			UNCLASSIFIED	1002
4424	79448440 (8289, 8290)			UNCLASSIFIED	1003
4425	99517906 (8295, 8296)			UNCLASSIFIED	1001, 1008, 1020, 1022,
					1036, 1041, 1055
4426	80082084 (8299, 8300)			UNCLASSIFIED	1020,1022, 1026, 1028,
					1031, 1035
4427	54528786 (8305, 8306)			UNCLASSIFIED	1038
4428	16333379 (8313, 8314)			UNCLASSIFIED	1004
4429	77894027 (8319, 8320)			UNCLASSIFIED	1019, 1033
4430	94233812(8321, 8322)			UNCLASSIFIED	1002, 1015, 1023, 1035,
					1050, 1051
4431	55183467 (8337, 8338)			UNCLASSIFIED	1017
4432	85540000 (8341, 8342)			UNCLASSIFIED	1035
4433	87455204 (8355, 8356)			UNCLASSIFIED	1023
4434	10853661 (8369, 8370)			UNCLASSIFIED	1015
4435	78378831 (8373, 8374)			UNCLASSIFIED	1041
4436	79763791 (8375, 8376)			UNCLASSIFIED	1020
4437	78914945 (8389, 8390)			UNCLASSIFIED	1036
4438	29897195 (8403, 8404)			UNCLASSIFIED	1022
4439	27839395 (8411, 8412)			UNCLASSIFIED	1020
4440	55929020 (8413, 8414)			UNCLASSIFIED	1019
4441	19887773 (8419, 8420)			UNCLASSIFIED	1031
4442	80399986 (8429, 8430)			UNCLASSIFIED	1006, 1023, 1026
4443	78374679 (8431, 8432)			UNCLASSIFIED	1006, 1024
4444	10104463 (8437, 8438)			UNCLASSIFIED	1035
4445	27977235 (8439, 8440)			UNCLASSIFIED	1004
4446	79763608 (8447, 8448)			UNCLASSIFIED	1021
4447	71059237 (8455, 8456)			UNCLASSIFIED	1022
4448	71845869 (8461, 8462)			UNCLASSIFIED	1027, 1033
4449	34761080 (8469, 8470)			UNCLASSIFIED	1027
4450	78946789 (8487, 8488)			UNCLASSIFIED	1019, 1033, 1038, 1051
4451	33101646 (8491, 8492)			UNCLASSIFIED	1024
4452	30394512 (8495, 8496)			UNCLASSIFIED	1035
4453	80200907 (8497, 8498)			UNCLASSIFIED	1020, 1022
4454	77515115 (8499, 8500)			UNCLASSIFIED	1002
4455	77881555 (8503, 8504)			UNCLASSIFIED	1019
4456	79778294 (8505, 8506)			UNCLASSIFIED	1015
4457	39734743 (8515, 8516)			UNCLASSIFIED	1024
4458	20281464 (8517, 8518)			UNCLASSIFIED	1031
4459	80021097 (8521, 8522)			UNCLASSIFIED	1004
4460	50401417 (8523, 8524)			UNCLASSIFIED	1033
4461	55506630 (8527, 8528)			UNCLASSIFIED	1019, 1024
4462	6598409 (8535, 8536)			UNCLASSIFIED	1020
4463	10080426 (8543, 8544)			UNCLASSIFIED	1015
4464	80424139 (8549, 8550)			UNCLASSIFIED	1003, 1008, 1023
4465	78058919 (8555, 8556)			UNCLASSIFIED	1022
4466	37026708 (8557, 8558)			UNCLASSIFIED	1035, 1041
4467	66049540 (8565, 8566)			UNCLASSIFIED	1005
4468	66139409 (8571, 8572)			UNCLASSIFIED	1003, 1010, 1020
4469	65891380 (8579, 8580)			UNCLASSIFIED	1051
4470	65981380 (8583, 8584)			UNCLASSIFIED	1051
4471	78948740 (8591, 8592)			UNCLASSIFIED	1001, 1015, 1031
4472	19905899 (8599, 8600)			UNCLASSIFIED	1008
4473	87115127 (8603, 8604)			UNCLASSIFIED	1023
4474	32296073 (8611, 8612)			UNCLASSIFIED	1000
4475	25183594 (8613, 8614)			UNCLASSIFIED	1002
4476	17903334 (8619, 8620)			UNCLASSIFIED	1021
4477	28459834 (8631, 8632)			UNCLASSIFIED	1002
4478	42942377 (8633, 8634)			UNCLASSIFIED	1000
4479	24133419 (8635, 8636)			UNCLASSIFIED	1002
4480	78788013 (8647, 8648)			UNCLASSIFIED	1002, 1006
4481	35073151 (8651, 8652)			UNCLASSIFIED	1047
4482	34697225 (8659, 8660)			UNCLASSIFIED	1022
4483	11076810 (8663, 8664)			UNCLASSIFIED	1008
4484	27842778 (8667, 8668)			UNCLASSIFIED	1003, 1008
4485	66437464 (8669, 8670)			UNCLASSIFIED	1022
4486	80206883 (8681, 8682)			UNCLASSIFIED	1031
4487	79114654 (8689, 8690)			UNCLASSIFIED	1002, 1006, 1007, 1014,
					1015, 1020, 1021, 1024,
					1034, 1036, 1041
4488	30256277 (8701, 8702)			UNCLASSIFIED	1041
4489	78377302 (8713, 8714)			UNCLASSIFIED	1024
4490	86476874 (8723, 8724)			UNCLASSIFIED	1026
4491	78387102 (8725, 8726)			UNCLASSIFIED	1024
4492	87456737 (8727, 8728)			UNCLASSIFIED	1023
4493	78913039 (8731, 8732)			UNCLASSIFIED	1027, 1041
4494	21430756 (8737, 8738)			UNCLASSIFIED	1003
4495	87453107 (8743, 8744)			UNCLASSIFIED	1023
4496	29006178 (8745, 8746)			UNCLASSIFIED	1041
4497	57057267 (8749, 8750)			UNCLASSIFIED	1051
4498	20754821 (8777, 8778)			UNCLASSIFIED	1050
4499	34411796 (8795, 8796)			UNCLASSIFIED	1022
4500	79190982 (8815, 8816)			UNCLASSIFIED	1022, 1035
4501	80026765 (8825, 8826)			UNCLASSIFIED	1003
4502	34885768 (8833, 8834)			UNCLASSIFIED	1014
4503	88097866 (8837, 8838)			UNCLASSIFIED	1016
4504	32712852 (8839, 8840)			UNCLASSIFIED	1026
4505	80412124 (8843, 8844)			UNCLASSIFIED	1026
4506	6512390 (8845, 8846)			UNCLASSIFIED	1020
4507	88464789 (8849, 8850)			UNCLASSIFIED	1026, 1031
4508	65881056 (8861, 8862)			UNCLASSIFIED	1051
4509	79111174 (8865, 8866)			UNCLASSIFIED	1024, 1041
4510	78432343 (8867, 8868)			UNCLASSIFIED	1031, 1051
4511	65468389 (8871, 8872)			UNCLASSIFIED	1051
4512	65648374 (8879, 8880)			UNCLASSIFIED	1051
4513	79862565 (8881, 8882)			UNCLASSIFIED	1041
4514	77883302 (8903, 8904)			UNCLASSIFIED	1019
4515	11088007 (8905, 8906)			UNCLASSIFIED	1020
4516	80077674 (8907, 8908)			UNCLASSIFIED	1004, 1031
4517	30797043 (8911, 8912)			UNCLASSIFIED	1014
4518	10845648 (8913, 8914)			UNCLASSIFIED	1001
4519	35101562 (8921, 8922)			UNCLASSIFIED	1022
4520	33200646 (8931, 8932)			UNCLASSIFIED	1024
4521	78473190 (8937, 8938)			UNCLASSIFIED	1024
4522	77915440 (8951, 8952)			UNCLASSIFIED	1033
4523	71760619 (8957, 8958)			UNCLASSIFIED	1002
4524	33764227 (8981, 8982)			UNCLASSIFIED	1024
4525	71768824 (8997, 8998)			UNCLASSIFIED	1002, 1051
4526	20396723 (9003, 9004)			UNCLASSIFIED	1008
4527	20728632 (9007, 9008)			UNCLASSIFIED	1022
4528	27980170 (9015, 9016)			UNCLASSIFIED	1004
4529	11706751 (9019, 9020)			UNCLASSIFIED	1035
4530	91236129 (9025, 9026)			UNCLASSIFIED	1042
4531	11773980 (9029, 9030)			UNCLASSIFIED	1023
4532	78238336 (9031, 9032)			UNCLASSIFIED	1024
4533	25242940 (9033, 9034)			UNCLASSIFIED	1041
4534	79619732 (9045, 9046)			UNCLASSIFIED	1023

[0340]

TABLE 2
tissue
id	tissue heirarchy	Common conditions/diseases	Other diseases
1000	Cardiovascular System/Artery/Coronary Artery
1001	Cardiovascular System/Heart	cancer, trauma, regeneration (in vitro and in	Cardiomyopathy,
		vivo), viral/bacterial/parasitic infections	Atherosclerosis, Hypertension,
			Congenital heart defects, Aortic stenosis,
			Atrial septal defect
			(ASD), Atrioventricular (A-V) canal defect,
			Ductus arteriosus, Pulmonary stenosis,
			Subaortic stenosis, Ventricular septal
			defect (VSD), valve diseases, Tuberous
			sclerosis, Scleroderma,
			Obesity, Transplantation
1002	Endocrine System/Adrenal	cancer, trauma, regeneration (in vitro and in	Adrenoleukodystrophy, Congenital
	Gland/Suprarenal gland	vivo), viral/bacterial/parasitic infections	Adrenal Hyperplasia,
1003	Endocrine System/Pancreas	cancer, trauma, regeneration (in vitro and in	Diabetes, Von Hippel-Lindau (VHL)
		vivo), viral/bacterial/parasitic infections	syndrome, Pancreatitis, Obesity
1004	Endocrine System/Thyroid	cancer, trauma, regeneration (in vitro and in	Hyperthyroidism and Hypothyroidism
		vivo), viral/bacterial/parasitic infections
1005	Female Reproductive System/Cervix	cancer, trauma, regeneration (in vitro and in	Fertility
		vivo), viral/bacterial/parasitic infections
1006	Female Reproductive System/Mammary	cancer, trauma, regeneration (in vitro and in	Fertility
	gland/Breast	vivo), viral/bacterial/parasitic infections
1007	Female Reproductive System/Ovary	cancer, trauma, regeneration (in vitro and in	Endometriosis, Fertility
		vivo), viral/bacterial/parasitic infections
1008	Female Reproductive System/Placenta	cancer, trauma, regeneration (in vitro and in	Fertility
		vivo), viral/bacterial/parasitic infections
1009	Female Reproductive
	System/Placenta/Chorionic Villus
1010	Female Reproductive System/Uterus	cancer, trauma, regeneration (in vitro and in	Endometriosis, Fertility
		vivo), viral/bacterial/parasitic infections
1011	Female Reproductive	cancer, trauma, regeneration (in vitro and in	Endometriosis Fertility
	System/Uterus/Myometrium	vivo), viral/bacterial/parasitic infections
1012	Gastro-intestinal/Digestive System/Large	cancer, trauma, regeneration (in vitro and in	Hirschsprung's disease, Crohn's
	Intestine/Colon	vivo), viral/bacterial/parasitic infections	Disease, Appendicitis
1013	Gastro-intestinal/Digestive System/Large
	Intestine/Colon/Ascending Colon
1014	Gastro-intestinal/Digestive System/Liver	cancer, trauma, regeneration (in vitro and in	Von Hippel-Lindau (VHL) syndrome,
		vivo), viral/bacterial/parasitic infections	Cirrhosis, Transplantation
1015	Gastro-intestinal/Digestive System/Salivary
	Glands
1016	Gastro-intestinal/Digestive System/Salivary
	Glands/Parotid Salivary glands
1017	Gastro-intestinal/Digestive System/Small
	Intestine
1018	Gastro-intestinal/Digestive System/Small
	Intestine/Duodenum
1019	Gastro-intestinal/Digestive System/Stomach	cancer, trauma, regeneration (in vitro and in	Hypercalceimia, Ulcers
		vivo), viral/bacterial/parasitic infections
1020	Hematopoietic and Lymphatic	cancer, trauma, regeneration (in vitro and in	Hemophilia, hypercoagulation, Idiopathic
	System/Hematopoietic Tissues/Bone	vivo), viral/bacterial/parasitic infections	thrombocytopenic purpura, autoimmume
	Marrow		disease, allergies,
			immunodeficiencies, transplantation,
			Graft vesus host,
1021	Hematopoietic and Lymphatic	cancer, trauma, regeneration (in vitro and in	Hemophilia, hypercoagulation, idiopathic
	System/Hematopoietic Tissues/Lymphoid	vivo), viral/bacterial/parasitic infections	thrombocytopenic purpura, autoimmume
	tissue		disease, allergies, immunodeficiencies,
			transplantation, Graft versus host
			disease (GVHD), Lymphaedema
1022	Hematopoietic and Lymphatic
	System/Hematopoietic Tissues/Lymphoid
	tissue/Lymph node
1023	Hematopoietic and Lymphatic	cancer, trauma, regeneration (in vitro and in	Hemophilia, Hypercoagulation, Idiopathic
	System/Hematopoietic Tissues/Lymphoid	vivo), viral/bacterial/parasitic infections	thrombocytopenic purpura,
	tissue/Spleen		Immunodeficiencies, Graft vesus host
1024	Hematopoietic and Lymphatic	cancer, trauma, regeneration (in vitro and in	Anemia, Ataxia-
	System/Hematopoietic Tissues/Peripheral	vivo), viral/bacterial/parasitic infections	telangiectasia, Autoimmume
	Blood		disease, Immunodeficiencies
1025	Hematopoietic and Lymphatic	cancer, trauma, regeneration (in vitro and in	Hemophilia, hypercoagulation, Idiopathic
	System/Hematopoietic Tissues/Thymus	vivo), viral/bacterial/parasitic infections	thrombocytopenic purpura,
			immunodeficiencies
1026	Male Reproductive System/Prostate	cancer, trauma, regeneration (in vitro and in	Fertility
		vivo), viral/bacterial/parasitic infections
1027	Male Reproductive System/Testis	cancer, trauma, regeneration (in vitro and in	Fertility
		vivo), viral/bacterial/parasitic infections
1028	Musculoskeletal System/Bone	cancer, trauma, regeneration (in vitro and in	Osteoporosis, Hypercalceimia, Arthritis,
		vivo), viral/bacterial/parasitic infections	Ankylosing spondylitis, Scoliosis
1029	Musculoskeletal System/Muscle	cancer, trauma, regeneration (in vitro and in	Muscular dystrophy, Lesch-Nyhan
		vivo), viral/bacterial/parasitic infections	syndrome, Myasthenia gravis
1030	Musculoskeletal System/Muscle/Skeletal	cancer, trauma, regeneration (in vitro and in	Muscular dystrophy, Lesch-Nyhan
	Muscle	vivo), viral/bacterial/parasitic infections	syndrome, Myasthenia gravis
1031	Nervous System/Brain	cancer, trauma, regeneration (in vitro and in	Von Hippel-Lindau (VHL) syndrome,
		vivo), viral/bacterial/parasitic infections	Alzheimer's disease, Stroke, Tuberous
			sclerosis, hypercalceimia, Parkinson's
			disease, Huntington's disease, Cerebral
			palsy, Epilepsy, Lesch-Nyhan syndrome,
			Multiple sclerosis, Ataxia-
			telangiectasia, Leukodystrophies, Behavioral
			disorders, Addiction, Anxiety, Pain,
			Neuroprotection
1032	Nervous System/Brain/Brain
	Stem/Hindbrain/Cerebellum
1033	Nervous System/Brain/Hippocampus
1034	Nervous
	System/Brain/Prosencephalon/Forebrain/
	Dienecephalon/Hypothalamus
1035	Nervous	cancer, trauma, regeneration (in vitro and in	Endocrine dysfunctions, Diabetes,
	SystemlBrain/Prosencephalon/Forebrain/	vivo), viral/bactenal/parasitic infections	obesity, Growth and reproductive
	Dienecephalon/Pituitary Gland		disorders
1036	Nervous
	System/Brain/Prosencephalon/Forebrain/
	Dienecephalon/Thalamus
1037	Nervous
	System/Brain/Prosencephalon/Forebrain/
	Telencephalon/Cerebrum/Cerebral
	Cortex/Cerebral Gray Matter/Cerebral
	gyri/Temporal Lobe/Amygdala
1038	Nervous System/Brain/Substantia Nigra	cancer, trauma, regeneration (in vitro and in	Von Hippel-Lindau (VHL) syndrome,
		vivo), viral/bacterial/parasitic infections	Alzheimer's disease, Stroke, Tuberous
			sclerosis, hypercalceimia, Parkinson's
			disease, Huntington's disease, Cerebral
			palsy, Epilepsy, Lesch-Nyhan syndrome,
			Multiple sclerosis, Ataxia-
			teiangiectasia, Leukodystrophies, Behavioral
			disorders, Addiction, Anxiety, Pain,
			Neuroprotection
1039	Nervous System/Spinal Chord
1040	Respiratory System/Larynx
1041	Respiratory System/Lung	cancer, trauma, regeneration (in vitro and in	Systemic lupus erythematosus,
		vivo), viral/bacterial/parasitic infections	Autoimmune disease, Asthma,
			Emphysema, Scleroderma
1042	Respiratory System/Lung/Lung Pleura
1043	Respiratory System/Trachea
1044	Sensory System/Eye/Retina	cancer, trauma, regeneration (in vitro and in	Von Hippel-Lindau (VHL) syndrome,
		vivo), viral/bacterial/parasitic infections	Diabetes, Tuberous sclerosis
1045	Sensory System/Skin	cancer, trauma, regeneration (in vitro and in	Psoriasis, Actinic keratosis, Tuberous
		vivo), viral/bacterial/parasitic infections	sclerosis
1046	Sensory System/Skin/Dermis
1047	Sensory System/Skin/Epidermis
1048	Sensory System/Skin/Epidermis/Hair
	Follicles
1049	Sensory System/Skin/Foreskin	cancer, trauma, regeneration (in vitro and in	Psoriasis, Actinic keratosis, Tuberous
		vivo), viral/bacterial/parasitic infections	sclerosis
1050	Tissue Not Assigned
1051	Urinary System/Kidney	cancer, trauma, regeneration (in vitro and in	Diabetes, Autoimmune disease, Renal
		vivo), viral/bacterial/parasitic infections	artery stenosis, Interstitial nephritis,
			Glomerulonephritis, Polycystic kidney
			disease, Systemic lupus erythematosus,
			Renal tubular acidosis, IgA nephropathy,
			Hypercalceimia, Lesch-Nyhan syndrome
1052	Urinary System/Kidney/Kidney Cortex
1053	Urinary System/Kidney/Kidney
	Cortex/Nephrons/Proximal Convoluted
	Tubule
1054	Urinary System/Urinary Bladder
1055	Whole Organism	cancer, trauma, tissue regeneration (in vitro
		and in vivo), viral/bacterial/parasitic infections,
		immunological disease, respiratory disease,
		gastro-intestinal diseases,
		reproductive health, neurological and
		neurodegenerative diseases, bone marrow
		transplantation, metabolic and endocrine
		diseases, allergy and inflammation,
		nephrological disorders, cardiovascular
		diseases, muscle, bone, joint and skeletal
		disorders, hematopoietic disorders, urinary
		system disorders

[0341]

Claims

1. An isolated nucleic acid molecule encoding a polypeptide comprising an amino acid sequence that is at least 85% identical to a polypeptide including an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is any integer 1-4534, or the complement thereof.

2. The isolated nucleic acid molecule of claim 1, said molecule hybridizing under stringent conditions to a nucleic acid sequence complementary to a nucleic acid molecule comprising the sequence of nucleotides selected from the group consisting of SEQ ID NO:2n−1, wherein n is any integer 1-4534, or the complement thereof.

3. The isolated nucleic acid molecule of claim 1, said molecule encoding a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is any integer 1-4534, or an amino acid sequence comprising one or more conservative substitutions in the amino acid sequence selected from the group consisting of SEQ ID NO: 2n.

4. The isolated nucleic acid molecule of claim 1, wherein said molecule encodes a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is any integer 1-4534.

5. The isolated nucleic acid molecule of claim 1, wherein said molecule comprises the sequence of nucleotides selected from the group consisting of SEQ ID NO:2n−1, wherein n is any integer 1-4534, or the complement thereof.

6. An oligonucleotide less than 100 nucleotides in length and comprising at least 6 contiguous nucleotides selected from the group consisting of SEQ ID NO:2n−1, wherein n is any integer 1-4534, or the complement thereof.

7. A vector comprising the nucleic acid molecule of claim 1.

8. The vector of claim 7, wherein said vector is an expression vector.

9. A host cell comprising the isolated nucleic acid molecule of claim 1.

10. A substantially purified polypeptide comprising an amino acid sequence at least 80% identical to a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is any integer 1-4534.

11. The polypeptide of claim 10, wherein said polypeptide comprises the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is any integer 1-4534.

12. An antibody that selectively binds to the polypeptide of claim 10.

13. A pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a therapeutic selected from the group consisting of: a) the nucleic acid of claim 1;b) the polypeptide of claim 10; and c) the antibody of claim 12;and a pharmaceutically acceptable carrier.

14. A kit comprising in one or more containers, a therapeutically or prophylactically effective amount of the pharmaceutical composition of claim 13.

15. A method of producing the polypeptide of claim 10, said method comprising culturing the host cell of claim 9 under conditions in which the nucleic acid molecule is expressed.

16. A method of detecting the presence of the polypeptide of claim 10 in a sample, comprising contacting the sample with a compound that selectively binds to said polypeptide under conditions allowing the formation of a complex between said polypeptide and said compound, and detecting said complex, if present, thereby identifying said polypeptide in said sample.

17. A method of detecting the presence of a nucleic acid molecule of claim 1 in a sample, the method comprising contacting the sample with a nucleic acid probe or primer that selectively binds to the nucleic acid molecule and determining whether the nucleic acid probe or primer bound to the nucleic acid molecule of claim 1 is present in the sample.

18. A method for modulating the activity of the polypeptide of claim 10, the method comprising contacting a cell sample comprising the polypeptide of claim 10 with a compound that binds to said polypeptide in an amount sufficient to modulate the activity of the polypeptide.

19. The use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a ORFX-associated disorder, wherein said therapeutic is selected from the group consisting of: a) the nucleic acid of claim 1;b) the polypeptide of claim 10; and c) the antibody of claim 12.

20. A method for screening for a modulator of activity or of latency or predisposition to an ORFX-associated disorder, said method comprising: a) contacting a test compound with the polypeptide of claim 10; and b) determining if said test compound binds to said polypeptide, wherein binding of said test compound to said polypeptide indicates the test compound is a modulator of activity or of latency or predisposition to an ORFX-associated disorder.

21. A method for screening for a modulator of activity or of latency or predisposition to an ORFX-associated disorder, said method comprising: a) administering a test compound to a test subject at an increased risk ORFX-associated disorder, wherein said test subject recombinantly expresses a polypeptide encoded by the nucleotide of claim 1;b) measuring expression the activity of said protein in said test subject; c) measuring the activity of said protein in a control subject that recombinantly expresses said protein and is not at increased risk for an ORFX-associated disorder; and d) comparing expression of said protein in said test subject and said control subject, wherein a change in the activity of said protein in said test subject relative to said control subject indicates the test compound is a modulator or of latency of predispostition to an ORFX-associated disorder.

22. The method of claim 20, wherein said test animal is a recombinant test animal that expresses a test protein transgene or expresses said transgene under the control of a promoter at an increased level relative to a wild-type test animal, and wherein said promoter is not the native gene promoter of said transgene.

23. A method for determining the presence of or predisposition to a disease associated with altered levels of a polypeptide of claim 11 in a subject, the method comprising: a) measuring the amount of the polypeptide in a sample from said subject; and b) comparing the amount of said polypeptide in step (a) to the amount of the polypeptide present in a control sample, wherein an alteration in the level of the polypeptide in step (a) as compared to the control sample indicates the presence of or predisposition to a disease in said subject.

24. The method of claim 23, wherein said subject is a human.

25. A method for determining the presence of or predisposition to a disease associated with altered levels the nucleic acid molecule of claim 1 in a subject, the method comprising: a) measuring the amount of the nucleic acid in a sample from the mammalian subject; and b) comparing the amount of said nucleic acid in step (a) to the amount of the nucleic acid present in a control sample, wherein an alteration in the level of the nucleic acid in step (a) as compared to the control sample indicates the presence of or predisposition to said disease in said subject.

26. The method of claim 25, wherein said subject is a human.

27. A method of treating or preventing a pathological condition associated with an ORFX-associated disorder in a subject, the method comprising administering to said subject the polypeptide of claim 10 in an amount sufficient to alleviate or prevent said pathological condition.

28. The method of claim 27, wherein said subject is a human.

29. A method of treating or preventing a pathological condition associated with an ORFX-associated disorder in a subject, the method comprising administering to said subject the nucleic acid molecule of claim 1 in an amount sufficient to alleviate or prevent said pathological condition.

30. The method of claim 29, wherein said subject is a human.

31. A method of treating or preventing a pathological condition associated with an ORFX-associated disorder in a subject, the method comprising administering to said subject the antibody of claim 12 in an amount sufficient to alleviate or prevent said pathological condition.

32. The method of claim 31, wherein said subject is a human.