Claims
- 1. A compound of the formula:
- 2. A compound according to the formula
- 3. A compound of the formula
- 4. A compound of the formula
- 5. A compound of the formula
- 6. A compound of the formula
- 7. A compound of the formula
- 8. A compound of the formula
- 9. A compound of the formula:
- 10. A compound of the formula
- 11. A compound of the formula
- 12. A compound of the formula
- 13. A compound of the formula
- 14. A compound of the formula
S-L-QUIN wherein S represents a single amino acid or a peptide of at least two amino acids; L is a linking group containing at least one carbon, oxygen, or nitrogen atom attached covalently to both S and QUIN, or a nonentity; and QUIN is a quinone, quinone derivative, hydroquinone, or hydroquinone derivative.
- 15. A compound according to claim 14, wherein S or a portion thereof, S-L or a portion thereof, or both S or a portion thereof and then L or a portion thereof, are cleaved from the quinone-containing remainder of the molecule by an enzyme.
- 16. A compound according to claim 15, wherein the enzyme is prostate specific antigen.
- 17. A compound according to claim 14, wherein L is —O—, —NH—, or —NH—(C1-C8 alkyl)-O—.
- 18. A compound according to claim 14, wherein L is —NH—(C6H4)CH2—O—(C═O)—NH—(C1-C8 alkyl)—O—.
- 19. A compound according to claim 14, wherein S is X-Ser-Lys-Leu-Gln, wherein X is a protecting group or an amino-terminal capping group, and the side chains of Ser, Lys, and Gln may optionally be protected with protecting groups.
- 20. A compound of the formula
S-L-QUIN wherein S represents a single amino acid or a peptide of at least two amino acids; L is a linking group containing at least one carbon, oxygen, or nitrogen atom attached covalently to both S and QUIN, or a nonentity; and QUIN is selected from the group consisting of the quinone compounds of claim 13 and the compounds 168
- 21. A method for making a compound according to claim 14, comprising the steps of
a) covalently linking L to S, and b) covalently linking L to QUIN, wherein steps a) and b) can be performed in either order or simultaneously.
- 22. A compound of the formula
- 23. A compound according to claim 22 of the formula
- 24. A compound according to claim 22, wherein W is —O—C1-C8 alkyl-NH—S, wherein S is a single amino acid or a peptide of two or more amino acids; wherein the group —NH— forms an amide bond with the alpha-carboxy group of S when S is a single amino acid and the group —NH— forms an amide bond with the C-terminal alpha-carboxy group of S when S is a peptide of two or more amino acids.
- 25. A compound according to claim 23, wherein W is —O—C1-C8 alkyl-NH—S, wherein S is a single amino acid or a peptide of two or more amino acids; wherein the group —NH— forms an amide bond with the alpha-carboxy group of S when S is a single amino acid and the group —NH— forms an amide bond with the C-terminal alpha-carboxy group of S when S is a peptide of two or more amino acids.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority benefit of co-pending provisional patent application U.S. Ser. No. 60/131,842, filed on Apr. 30, 1999. The content of that application is hereby incorporated by reference herein in its entirety.
STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH
[0002] Not applicable.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60131842 |
Apr 1999 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09562980 |
Apr 2000 |
US |
Child |
10139978 |
May 2002 |
US |