Claims
- 1. A phenylacetic acid amide compound of the formula ##STR14## in which each of R.sub.1 and R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, each of R.sub.3 and R.sub.4 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35, R.sub.5 is lower alkylene or lower alkylidene, R.sub.6 is carboxyl or lower alkoxycarbonyl, R.sub.7 is hydrogen and R.sub.8 is hydroxy or lower alkoxy, wherein the radical of the formula --NR.sub.7 -- R.sub.5 (R.sub.6)--CO--R.sub.8 has the D-configuration, or a therapeutically acceptable salt thereof.
- 2. A compound as claimed in claim 1, in which formula R.sub.1 is hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, halogen having an atomic number of not more than 35, or trifluoromethyl, each of R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, or halogen having an atomic number of not more than 35, R.sub.5 is alkylene or alkylidene having not more than 7 carbon atoms each, R.sub.6 is carboxyl or alkoxycarbonyl having not more than 4 carbon atoms in said alkoxy moiety, R.sub.7 is hydrogen and R.sub.8 is hydroxy or alkoxy having not more than 4 carbon atoms, wherein the radical --NR.sub.7 --R.sub.5 (R.sub.6)--COR.sub.8 has the D-configuration, or a therapeutically acceptable salt thereof.
- 3. A compound as claimed in claim 1 and having the formula ##STR15## in which R.sub.1 ' is alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35 and R.sub.3 ' is hydrogen, with the proviso that R.sub.3 ' can also be alkyl having not more than 4 carbon atoms, in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, R.sub.5 ' is alkyl having not more than 4 carbon atoms, which is substituted by carboxyl or alkoxycarbonyl having not more than 4 carbon atoms in said alkoxy moiety, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms wherein the radical of the formula --NH--CHR.sub.5 ' --CO--R.sub.8 ' has the D-configuration, or a therapeutically acceptable salt thereof.
- 4. A compound as claimed in claim 3, in which formula R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' is hydrogen, or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.5 ' is alkyl having not more than 4 carbon atoms which is substituted by carboxyl or alkoxycarbonyl having not more than 4 carbon atoms in said alkoxy moiety, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms, wherein the radical of the formula --NH--CH(R.sub.5 ')--C.dbd.O)--R.sub.8 ' has the D-configuration, or a therapeutically acceptable salt thereof.
- 5. A compound as claimed in claim 1 being dimethyl D-(-)-N-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-glutamate.
- 6. A compound as claimed in claim 1 being D-(-)-N-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-glutamic acid.
- 7. A compound as claimed in claim 1 being D-(-)-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-aspartic acid or a sodium salt thereof.
- 8. A compound as claimed in claim 1 being monosodium D-(-)-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-glutamate.
- 9. A pharmaceutical preparation containing an anti-inflammatory effective amount of a compound as claimed in claim 1 together with conventional pharmaceutical excipients.
Priority Claims (1)
Number |
Date |
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Kind |
77316 |
May 1977 |
LUX |
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CROSS REFERENCE
This is a continuation of our copending applications Ser. No. 905,087, filed May 11, 1978 (now abandoned) and Ser. No. 906,292, filed May 15, 1978 (now abandoned).
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3536758 |
Sallmann et al. |
Oct 1970 |
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3652762 |
Sallmann |
Mar 1972 |
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3897782 |
Boltze et al. |
Jul 1975 |
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Foreign Referenced Citations (2)
Number |
Date |
Country |
2618936 |
Nov 1976 |
DEX |
7244221 |
Aug 1972 |
JPX |
Non-Patent Literature Citations (1)
Entry |
Sallmann et al., Chem. Abst, vol. 77, #19403v, (1972). |
Related Publications (1)
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906292 |
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Continuations (1)
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905087 |
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