Claims
- 1. A compound of the formula ##STR14## in which R.sub.1 is lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35 and R.sub.3 is hydrogen, with the proviso that R.sub.3 ' can also be lower alkyl having not more than 4 carbon atoms, in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of said halogen atoms and R.sub.2 ' is hydrogen, and R.sub.5 ' is lower alkyl having not more than 4 carbon atoms substituted by hydroxyl or lower alkoxy, and R.sub.8 ' is hydroxyl, lower alkoxy having not more than 4 carbon atoms or substituted or unsubstituted amino, substituted amino being a radical of the formula --NH--CH(R.sub.5.sup.a')--C(.dbd.O)--R.sub.8.sup.a', in which R.sub.5.sup.a', and R.sub.8.sup.a' have the meanings for R.sub.5 ' and R.sub.8 ' respectively, and a radical of the formula --NH--CH(R.sub.5 ')--C(.dbd.O)--R.sub.8 ' consisting of one, two or three aminoacid radicals, or a therapeutically acceptable salt thereof.
- 2. A compound according to claim 1 in which R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' is hydrogen, or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.5 ' is hydrogen or lower alkyl having not more than 4 carbon atoms which is unsubstituted or substituted by hydroxy or lower alkoxy, and R.sub.8 ' is hydroxy, lower alkoxy, amino or substituted amino, substituted amino being a radical of the formula --NH--CH(R.sub.5.sup.a')--C(.dbd.O)--R.sub.8.sup.a', in which R.sub.5.sup.a' and R.sub.8.sup.a' have the meanings defined for R.sub.5 ' and R.sub.8 ' respectively, and a radical of the formula --NH--CH(R.sub.5 ')--C(.dbd.O)--R.sub.8 ' consisting of one, two or three aminoacid radicals, or a therapeutically acceptable salt thereof.
- 3. A compound according to claim 1, in which the radical --NH--CH(R.sub.5 ')--C(.dbd.O)-- has the D-configuration.
- 4. A pharmaceutical preparation containing an antiinflammatory effective amount of a compound as claimed in claim 1 together with conventional pharmaceutical excipients.
- 5. A compound of the formula ##STR15## in which each of R.sub.1 and R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, each of R.sub.3 and R.sub.4 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35, R.sub.5 is lower alkylene or lower alkylidene, R.sub.6 is hydroxyl or lower alkoxy, R.sub.7 is hydrogen and R.sub.8 is hydroxy or lower alkoxy, or a therapeutically acceptable salt thereof.
- 6. A compound as claimed in claim 5, in which formula R.sub.1 is hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, halogen having an atomic number of not more than 35, or trifluoromethyl, each of R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, or halogen having an atomic number of not more than 35, R.sub.5 is alkylene or alkylidene having not more than 7 carbon atoms each, R.sub.6 is hydroxyl or lower alkoxy, R.sub.7 is hydrogen and R.sub.8 is hydroxy or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 7. A compound as claimed in claim 1 and having the formula ##STR16## in which R.sub.1 ' is alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35 and R.sub.3 ' is hydrogen, with the proviso that R.sub.3 ' can also be alkyl having not more than 4 carbon atoms, in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, R.sub.5 ' is alkyl having not more than 4 carbon atoms, which is substituted by hydroxyl or lower alkoxy, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms or a therapeutically acceptable salt thereof.
- 8. A compound as claimed in claim 1, in which formula R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' is hydrogen, or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.5 ' is alkyl having not more than 4 carbon atoms which is substituted by hydroxyl or lower alkoxy, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable saltg thereof.
- 9. A compound as claimed in claim 1 being L(+)-N-{[2-(2,6-dichlorophenyl-amino)phenyl]acetyl}-serine or a pharmaceutically acceptable salt thereof.
- 10. A compound as claimed in claim 1 being D-(-)-N-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-serine or a pharmaceutically acceptable salt thereof.
- 11. A compound as claimed in claim 1 being the methyl ester of N-{[2-(2,6-dichlorophenyl-amino)-phenyl]acetyl}L-seryl-L-threonine.
- 12. A compound as claimed in claim 1 being the sodium salt of D(-)-N-{[2-(2,6-dichlorophenyl-amino)phenyl]-acetyl}-serine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
77316 |
May 1977 |
LUX |
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CROSS REFERENCE
This is a divisional of application Ser. No. 033,295 filed on Apr. 25, 1979, now U.S. Pat. No. 4,250,192, which is a continuation of our copending applications Ser. No. 905,087, filed May 11, 1978, abandoned and Ser. No. 906,292, filed May 15, 1978 abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3536758 |
Sallmann et al. |
Oct 1970 |
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3652762 |
Sallmann |
Mar 1972 |
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3897782 |
Boltye et al. |
Jul 1975 |
|
4143151 |
Wagner et al. |
May 1979 |
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Related Publications (1)
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Number |
Date |
Country |
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906292 |
May 1978 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
33295 |
Apr 1979 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
905087 |
May 1978 |
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