Claims
- 1. A compound of the formula ##STR14## in which R.sub.1 ' is lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of more than 35 and R.sub.3 ' is hydrogen, with the proviso that R.sub.3 ' can also be lower alkyl having not more than 4 carbon atoms, in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, and R.sub.5 ' is lower alkyl having not more than 4 carbon atoms, which is substituted by mercapto, lower alkylthio having not more than 4 carbon atoms, or S'-substituted dithio, the second sulfur atom in the S'-substituted dithio group containing, as a substituent, the radical of a compound of the formula III which is bonded via the grouping R.sub.5 ' and in which R.sub.1 ', R.sub.2 ' R.sub.3 ', R.sub.5 ' and R.sub.8 ' are as defined, and R.sub.8 ' is hydroxyl, lower alkoxy having not more than 4 carbon atoms or substituted or unsubstituted amino, substituted amino being a radical of the formula --NH--CH(R.sub.5.sup.a')--C(.dbd.O)-R.sub.8.sup.a' in which R.sub.5.sup.a' and R.sub.8.sup.a' have the meanings defined for R.sub.5 ' and R.sub.8 ' respectively, and a radical of the formula --NH--CH(R.sub.5 ')--C(.dbd.O)-R.sub.8 ' consisting of one, two or three aminoacid radicals, or a therapeutically acceptable salt thereof.
- 2. A compound according to claim 1 wherein the radical of the formula --NH--CH(R.sub.5 ')--C(.dbd.O)-- has the D-configuration.
- 3. A compound of the formula ##STR15## in which each of R.sub.1 and R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, each of R.sub.3 and R.sub.4 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35, R.sub.5 is lower alkylene or lower alkylidene, R.sub.6 is mercapto, lower alkylthio or S'-substituted dithio, the second sulfur atom in the S'-substituted dithio group containing, as a substituent, the radical of a compound of the formula I which is bonded via the grouping R.sub.6, an in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7 and R.sub.8 are as defined, R.sub.7 is hydrogen and R.sub.8 is hydroxy or lower alkoxy, or a therapeutically acceptable salt thereof.
- 4. A compound as claimed in claim 3, in which R.sub.1 is hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, halogen having an atomic number of not more than 35, or trifluoromethyl, each of R.sub.2, R.sub.3 and R.sub.4 is hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, or halogen having an atomic number of not more than 35, R.sub.5 is alkylene or alkylidene having not more than 7 carbon atoms each, and R.sub.8 is hydroxy or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 5. A compound as claimed in claim 1 wherein R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 6. A compound as claimed in claim 1 wherein R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' hydrogen, or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 7. A compound as claimed in claim 1 of the formula ##STR16## in which R.sub.1 ' is lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35 and R.sub.3 ' is hydrogen, with the proviso that R.sub.3 ' can also be lower alkyl having not more than 4 carbon atoms, in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, and R.sub.5 ' is lower alkyl having not more than 4 carbon atoms, which is substituted by mercapto, lower alkylthio having not more than 4 carbon atoms, or S'-substituted dithio, the second sulphur atom in a S'-substituted dithio group containing, as a substituent, the radical of a compound of the formula II which is bonded via the grouping R.sub.5 ' and in which R.sub.1 ', R.sub.2 ', R.sub.3 ', R.sub.5 ' and R.sub.8 ' are as defined, and R.sub.8 ' is hydroxyl, lower alkoxy having not more than 4 carbon atoms or substituted or unsubstituted amino, substituted amino being a radical of the formula --NH--CH(R.sub.5.sup.a')--C(.dbd.O)--R.sub.8.sup.a' (IIIa), in which R.sub.5.sup.a' and R.sub.8.sup.a' have the meanings defined for R.sub.5 ' and R.sub.8 ' respectively, and a radical of the formula --NH--CH(R.sub.5 ')--C(.dbd.O)--R.sub.8 ' (IIIb) consisting of one, two or three aminoacid radicals, or a therapeutically acceptable salt thereof.
- 8. A compound of the formula III according to claim 1, in which R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' is hydrogen, or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.5 ' is hydrogen or lower alkyl having not more than 4 carbon atoms which is substituted by mercapto, and R.sub.8 ' is hydroxyl, lower alkoxy, amino or substituted amino, substituted amino being a radical of the formula --NH--CH(R.sub.5.sup.a')--C(.dbd.O)--R.sub.8.sup.a' (IIIa), in which R.sub.5.sup.a' and R.sub.8.sup.a' have the meanings defined for R.sub.5 ' and R.sub.8 ' respectively, and a radical of the formula --NH--CH(R.sub.5 ')--C(.dbd.O)--R.sub.8 ' (IIIb) consisting of one, two or three aminoacid radicals, or a therapeutically acceptable salt thereof.
- 9. A pharmaceutical preparation containing an antiinflammatory effective amount of a compound as claimed in claim 1 together with conventional pharmaceutical excipients.
- 10. A compound as claimed in claim 1 being the L(+)-N-{[2(2,6-dichlorophenylamino)phenyl]acetyl}-cysteine or a pharmaceutically acceptable salt thereof.
- 11. A compound as claimed in claim 1 being the L-(-)-bis-N-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-cysteine or a pharmaceutically acceptable salt thereof.
- 12. A compound as claimed in claim 1 being the D-(-)-N-{[2-(2,6-dichlorophenylamino)-phenyl]acetyl}-methionine or a pharmaceutically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
77316 |
May 1977 |
LUX |
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CROSS REFERENCE
This is a divisional of application Ser. No. 033,295 filed on Apr. 25, 1979, now U.S. Pat. No. 4,250,192 which is a continuation of our copending applications Ser. No. 905,087, filed May 11, 1978 now abandoned and Ser. No. 906,292, filed May 15, 1978 now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3536758 |
Sallmann et al. |
Oct 1970 |
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3652762 |
Sallmann |
Mar 1972 |
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3897782 |
Boltye et al. |
Jul 1975 |
|
4207341 |
Hubner et al. |
Jun 1980 |
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Related Publications (1)
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Number |
Date |
Country |
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906292 |
May 1978 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
33295 |
Apr 1979 |
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Continuations (1)
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Number |
Date |
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Parent |
905087 |
May 1978 |
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