Claims
- 1. A compound of the formula ##STR14## in which each of R.sub.1 and R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, each of R.sub.3 and R.sub.4 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35, R.sub.5 is lower alkylene or lower alkylidene, R.sub.6 is amino or guanidino, R.sub.7 is hydrogen and R.sub.8 is hydroxy or lower alkoxy, or a therapeutically acceptable salt thereof.
- 2. A compound as claimed in claim 1, in which formula R.sub.1 is hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, halogen having an atomic number of not more than 35, or trifluoromethyl, each of R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkyl or alkoxy having not more than 4 carbon atoms each, or halogen having an atomic number of not more than 35, R.sub.5 is alkylene or alkylidene having not more than 7 carbon atoms each, R.sub.6 is amino or guanidino, R.sub.7 is hydrogen and R.sub.8 is hydroxy or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 3. A compound as claimed in claim 1 and having the formula ##STR15## in which R.sub.1 ' is alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35; R.sub.3 ' is hydrogen, with the proviso that R.sub.3 ' can also be alkyl having not more than 4 carbon atoms, in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, R.sub.5 ' is alkyl having not more than 4 carbon atoms, which is substituted by amino or guanidino, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms or a therapeutically acceptable salt thereof.
- 4. A compound as claimed in claim 3, in which formula R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' is hydrogen; or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.5 ' is alkyl having not more than 4 carbon atoms which is substituted by amino or guanidino, and R.sub.8 ' is hydroxyl or alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 5. A compound as claimed in claim 3 being L-N-.alpha.-{[2-(2,6-dichlorophenyl-amino)phenyl]acetyl}-lysine, the methyl ester or a pharmaceutically acceptable salt thereof.
- 6. A compound as claimed in claim 3 being L-N-.epsilon.-{[2-(2,6-dichlorophenyl-amino)-phenyl]-acetyl}-lysine, the methyl ester or a pharmaceutically acceptable salt thereof.
- 7. A compound as claimed in claim 3 being D-N-.alpha.-{[2-(2,6-dichlorophenyl-amino)-phenyl]acetyl}lysine, the methyl ester or a pharmaceutically acceptable salt thereof.
- 8. A compound as claimed in claim 3 being D-N-.alpha.-{[2-(2,6-dichlorophenyl-amino)phenyl]-acetyl}arginine or a pharmaceutically acceptable salt thereof.
- 9. A compound according to claim 1 or 3, in which the aminoacid corresponding to the radical of the formula --N(R.sub.7)--R.sub.5 (R.sub.6)--C(.dbd.O)-- or --NH--CH(R'.sub.5)--C(.dbd.O)--, respectively, has the D-configuration.
- 10. A pharmaceutical preparation containing an antiinflammatory effective amount of a compound as claimed in claim 1 together with conventional pharmaceutical excipients.
Priority Claims (1)
Number |
Date |
Country |
Kind |
77316 |
May 1977 |
LUX |
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CROSS REFERENCE
This is a Divisional of application Ser. No. 033,295 filed on Apr. 25, 1979, now U.S. Pat. No. 4,250,192. This is a continuation of our copending applications Ser. No. 905,087, filed May 11, 1978 now abandoned and Ser. No. 906,292, filed May 15, 1978 now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3536758 |
Sallmann et al. |
Oct 1970 |
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3652762 |
Sallmann |
Mar 1972 |
|
3897782 |
Boltze et al. |
Jul 1975 |
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Related Publications (1)
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Number |
Date |
Country |
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906292 |
May 1978 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
33295 |
Apr 1979 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
905087 |
May 1978 |
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