Claims
- 1. An apparatus, comprising an NMR probe device, including:
an RF excitation source; a first coil operable to be disposed about a first sample to detect a first sample response to an excitation signal from said RF excitation source; and a second coil operable to be disposed about a second sample to detect a second sample response to the excitation signal, said second coil being electrically connected in series with said first coil; wherein said first coil and said second coil are disposed relative to said RF excitation source to provide a phase difference between the first sample response and the second sample response to at least partially cancel one or more response components corresponding to a common material in the first sample and the second sample.
- 2. The apparatus of claim 1, wherein said first coil and said second coil are geometrically oriented to provide said phase difference of about 180 degrees.
- 3. The apparatus of claim 1, further comprising a first sample holder disposed within said first coil to receive the first sample and a second sample holder disposed within said second coil to receive the second sample.
- 4. The apparatus of claim 1, wherein said first coil and said second coil are each of a saddle or solenoid configuration.
- 5. The apparatus of claim 1, further comprising an excitation coil positioned about said first coil and said second coil.
- 6. An apparatus, comprising an NMR probe device, including:
an RF excitation source; a first coil operable to be disposed about a first sample to detect a first sample response to an excitation signal from said RF excitation source; a second coil operable to be disposed about a second sample to detect a second sample response to the excitation signal, said second coil being connected in series with said first coil; and an excitation coil positioned about said first coil and said second coil, wherein said first coil and said second coil are disposed relative to said RF excitation source to provide a phase difference between the first sample response and the second sample response to at least partially cancel one or more response components corresponding to a common material in the first sample and the second sample, and wherein said first coil is positioned about a first axis, said second coil is positioned about a second axis, said excitation coil is positioned about a third axis, and said first and second axes are generally perpendicular to said third axis.
- 7. The apparatus of claim 1, wherein said RF excitation sources includes an NMR transmitter coupled to said first coil and said second coil to excite the first sample and the second sample in parallel, and further comprising:
a magnetic field source proximate to a sample space configured to receive said probe device; and at least one NMR receiver coupled to said first coil and said second coil.
- 8. The apparatus of claim 1, wherein said first coil and said second coil are each of a microcoil variety with a diameter of less than about 1 millimeter.
- 9. A method, comprising:
preparing a first sample comprised of a solvent and a second sample comprised of a mixture of the solvent and an analyte; exciting the first sample and the second sample to perform NMR analysis of the analyte; and detecting a first sample response with a first coil and a second sample response with a second coil, the first sample response including a phase difference relative to the second sample response at a frequency corresponding to the solvent to reduce solvent interference with the NMR analysis of the analyte.
- 10. The method of claim 9, wherein said exciting includes exposing the first sample and the second sample to an RF signal radiated by an excitation coil disposed about the first coil and the second coil.
- 11. The method of claim 9, wherein said exciting includes providing an RF signal to the first sample with the first coil and to the second sample with the second coil.
- 12. The method of claim 9, wherein the phase difference is approximately 180 degrees.
- 13. The method of claim 9, further comprising disposing a first sample holder within the first coil to receive the first sample and a second sample holder within the second coil to receive the second sample.
- 14. The method of claim 9, wherein the first coil is wired in series with the second coil.
- 15. A method, comprising:
preparing first and second samples having a first substance common thereto, the second sample comprising a mixture of the common substance and a second substance; exciting the first sample and the second sample to perform NMR analysis; detecting sample responses with a probe including first and second coils, said first coil generating a first sample response signal and said second coil generating a second sample response signal; developing a phase difference in the probe between said first and second sample response signals; and combining differently phased sample response signals in said probe to produce a probe output signal in which a spectral component corresponding to the common substance is at least partially cancelled.
- 16. The method of claim 15, wherein said exciting includes exposing the first sample and the second sample to an RF signal radiated by an excitation coil disposed about the first coil and the second coil.
- 17. The method of claim 15, wherein said exciting includes providing an RF signal to the first sample with the first coil and to the second sample with the second coil.
- 18. The method of claim 15, wherein the phase difference is approximately 180 degrees.
- 19. The method of claim 15, further comprising disposing a first sample holder within the first coil to receive the first sample and a second sample holder within the second coil to receive the second sample.
- 20. The method of claim 15, wherein the first coil is wired in series with the second coil.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application claims the benefit of provisional patent application No. 60/121,869, filed Feb. 26, 1999, which is hereby incorporated by reference; and is a continuation of application No. PCT/US00/04842, filed Feb. 25, 2000; and is a division of application Ser. No. 09/938,996, filed Aug. 24, 2001, now U.S. Pat. No. 6,696,838, which is hereby incorporated by reference.
GOVERNMENT RIGHTS
[0002] The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of the National Science Foundation (NSF) grant number CHE 95-31693 under contract number 500-1393-3104.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60121869 |
Feb 1999 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09938996 |
Aug 2001 |
US |
Child |
10785918 |
Feb 2004 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/US00/04842 |
Feb 2000 |
US |
Child |
09938996 |
Aug 2001 |
US |