Claims
- 1. A DNA molecule which encodes a polypeptide which is capable of binding human TNF.alpha. and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the group consisting of the 55 kD and 75 kD receptors for human TNF.alpha..
- 2. A DNA molecule according to claim 1, which has the nucleotide sequence of SEQ ID NO:3.
- 3. A DNA molecule according to claim 1, which has fused to the 5'-end thereof a sequence which encodes a signal amino acid sequence.
- 4. A DNA molecule according to claim 1, which has the nucleotide sequence of SEQ ID NO:1.
- 5. A DNA molecule according to claim 1, which is a vector and which is capable, when provided in a suitable host, of expressing said polypeptide.
- 6. A DNA molecule according to claim 5, which is a plasmid.
- 7. A host cell transformed with a DNA molecule as claimed in claim 5.
- 8. A host cell according to claim 7, which is a mammalian cell.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9022648 |
Oct 1990 |
GBX |
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Parent Case Info
This application is a divisional of U.S. patent application Ser. No. 08/050,319, filed a PCT/GB91/01826 Oct. 18, 1991, now U.S. Pat. No. 5,633,145.
Foreign Referenced Citations (2)
Number |
Date |
Country |
308378 |
Mar 1989 |
EPX |
393438 |
Oct 1990 |
EPX |
Non-Patent Literature Citations (4)
Entry |
Schall et al., Cell (1990) 61:361-370. |
Loetscher et al., Cell (1990) 61:351-359. |
Gray et al., Proc. Natl. Acad. Sci. USA (1990) 87:7380-7384. |
Yan et al., J. Biol. Chem. (1991) 266(18):12098-12104. |
Divisions (1)
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Number |
Date |
Country |
Parent |
50319 |
May 1993 |
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