NUCLEIC ACID-GUIDED NUCLEASES

INCORPORATION BY REFERENCE

Submitted with the present application is an electronically filed sequence listing via EFS-Web as an ASCII formatted sequence listing, entitled “INSC104US8_seqlist_20220309”, created Mar. 9, 2022, and 791,000 bytes in size. The sequence listing is part of the specification filed herewith and is incorporated by reference in its entirety.

BACKGROUND OF THE DISCLOSURE

Nucleic acid-guided nucleases have become important tools for research and genome engineering. The applicability of these tools can be limited by the sequence specificity requirements, expression, or delivery issues.

SEQUENCE LISTING

This application contains a sequence list in Table 6.

SUMMARY OF THE DISCLOSURE

Disclosed herein are methods of modifying a target region in the genome of a cell, the method comprising: (a) contacting a cell with: a non-naturally occurring nucleic-acid-guided nuclease encoded by a nucleic acid having at least 80% identity to SEQ ID NO: 22; an engineered guide nucleic acid capable of complexing with the nucleic acid-guided nuclease; and an editing sequence encoding a nucleic acid complementary to said target region having a change in sequence relative to the target region; and (b) allowing the nuclease, guide nucleic acid, and editing sequence to create a genome edit in a target region of the genome of the cell. In some aspects, the engineered guide nucleic acid and the editing sequence are provided as a single nucleic acid. In some aspects, the single nucleic acid further comprises a mutation in a protospacer adjacent motif (PAM) site. In some aspects, the nucleic acid-guided nuclease is encoded by a nucleic acid with at least 85% identity to SEQ ID NO: 42. In some aspects, the nucleic acid-guided nuclease is encoded by a nucleic acid with at least 85% identity to SEQ ID NO: 128.

Disclosed herein are nucleic acid-guided nuclease systems comprising: (a) a non-naturally occurring nuclease encoded by a nucleic acid having at least 80% identity to SEQ ID NO: 22; (b) an engineered guide nucleic acid capable of complexing with the nucleic acid-guided nuclease, and (c) an editing sequence having a change in sequence relative to the sequence of a target region in a genome of a cell; wherein the system results in a genome edit in the target region in the genome of the cell facilitated by the nuclease, the engineered guide nucleic acid, and the editing sequence. In some aspects, nucleic acid-guided nuclease is encoded by a nucleic acid with at least 85% identity to SEQ ID NO: 42. In some aspects, the nucleic acid-guided nuclease is encoded by a nucleic acid with at least 85% identity to SEQ ID NO: 128. In some aspects, the nucleic acid-guided nuclease is codon optimized for the cell to be edited. In some aspects, the engineered guide nucleic acid and the editing sequence are provided as a single nucleic acid. In some aspects, the single nucleic acid further comprises a mutation in a protospacer adjacent motif (PAM) site.

Disclosed herein are compositions for use in genome editing comprising a non-naturally occurring nuclease encoded by a nucleic acid having at least 75% identity to SEQ ID NO: 22. In some aspects, the nucleic acid has at least 80% identity to SEQ ID NO: 22. In some aspects, the nucleic acid has at least 90% identity to SEQ ID NO: 22. In some aspects, the nuclease is further codon optimized for use in cells from a particular organism. In some aspects, the nuclease is codon optimized for E. Coli In some aspects, the nuclease is codon optimized for S. Cerevisiae. In some aspects, the nuclease is codon optimized for mammalian cells. In some aspects, the nucleic acid-guided nuclease has less than 40% protein identity to SEQ ID NO: 12. In some aspects, the nucleic acid-guided nuclease has less than 40% protein identity to SEQ ID NO: 108.

INCORPORATION BY REFERENCE

All publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS

This patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.

FIG. 1A depicts a partial sequence alignment MAD1-8 (SEQ ID NO: 1-8) and MAD10-12 (SEQ ID NO: 10-12).

FIG. 1B depicts a phylogenetic tree of nucleases including MAD1-8.

FIG. 2 depicts an example protein expression construct.

FIG. 3 depicts an example editing cassette.

FIG. 4 depicts an example screening or selection experiment workflow.

FIG. 5A depicts an example protein expression construct.

FIG. 5B depicts an example editing cassette.

FIG. 5C depicts an example screening or selection experiment workflow.

FIG. 6A depicts an example protein expression construct.

FIG. 6B depicts an example editing cassette.

FIG. 6C depicts an example screening or selection experiment workflow.

FIG. 7A-7B depicts example data from a functional nuclease complex screening or selection experiment.

FIG. 8 depicts example data from a targetable nuclease complex-based editing experiment.

FIG. 9 depicts example data from a targetable nuclease complex-based editing experiment.

FIGS. 10A-10C depict example data from a targetable nuclease complex-based editing experiment.

FIG. 11 depicts a example sequence alignment of select sequences from an editing experiment.

FIG. 12 depicts example data from a targetable nuclease complex-based editing experiment.

FIG. 13A depicts an example alignment of scaffold sequences.

FIG. 13B depicts an example model of a nucleic acid-guided nuclease complexed with a guide nucleic acid and a target sequence.

FIG. 14A-14B depict example data from a primer validation experiment.

FIG. 15 depicts example data from a targetable nuclease complex-based editing experiment.

FIG. 16 depicts example validation data comparing results from two different assays.

FIG. 17A-17C depict an example trackable genetic engineering workflow, including a plasmid comprising an editing cassette and a recording cassette, and downstream sequencing of barcodes in order to identify the incorporated edit or mutation.

FIG. 18 depicts an example trackable genetic engineering workflow, including iterative rounds of engineering with a different editing cassette and recorder cassette with unique barcode (BC) at each round, which can be followed by selection and tracking to confirm the successful engineering step at each round.

FIG. 19 depicts an example recursive engineering workflow.

DETAILED DESCRIPTION OF THE DISCLOSURE

The present disclosure provides nucleic acid-guided nucleases and methods of use. Often, the subject nucleic-acid guided nucleases are part of a targetable nuclease system comprising a nucleic acid-guided nuclease and a guide nucleic acid. A subject targetable nuclease system can be used to cleave, modify, and/or edit a target polynucleotide sequence, often referred to as a target sequence. A subject targetable nuclease system refers collectively to transcripts and other elements involved in the expression of or directing the activity of genes, which may include sequences encoding a subject nucleic acid-guided nuclease protein and a guide nucleic acid as disclosed herein.

Methods, systems, vectors, polynucleotides, and compositions described herein may be used in various applications including altering or modifying synthesis of a gene product, such as a protein, polynucleotide cleavage, polynucleotide editing, polynucleotide splicing; trafficking of target polynucleotide, tracing of target polynucleotide, isolation of target polynucleotide, visualization of target polynucleotide, etc. Aspects of the invention also encompass methods and uses of the compositions and systems described herein in genome engineering, e.g. for altering or manipulating the expression of one or more genes or the one or more gene products, in prokaryotic, archaeal, or eukaryotic cells, in vitro, in vivo or ex vivo.

Nucleic Acid-Guided Nucleases

Bacterial and archaeal targetable nuclease systems have emerged as powerful tools for precision genome editing. However, naturally occurring nucleases have some limitations including expression and delivery challenges due to the nucleic acid sequence and protein size. Targetable nucleases that require PAM recognition are also limited in the sequences they can target throughout a genetic sequence. Other challenges include processivity, target recognition specificity and efficiency, and nuclease acidity efficiency, which often effect genetic editing efficiency.

Non-naturally occurring targetable nucleases and non-naturally occurring targetable nuclease systems can address many of these challenges and limitations.

Disclosed herein are non-naturally targetable nuclease systems. Such targetable nuclease systems are engineered to address one or more of the challenges described above and can be referred to as engineered nuclease systems. Engineered nuclease systems can comprise one or more of an engineered nuclease, such as an engineered nucleic acid-guided nuclease, an engineered guide nucleic acid, an engineered polynucleotides encoding said nuclease, or an engineered polynucleotides encoding said guide nucleic acid. Engineered nucleases, engineered guide nucleic acids, and engineered polynucleotides encoding the engineered nuclease or engineered guide nucleic acid are not naturally occurring and are not found in nature. It follows that engineered nuclease systems including one or more of these elements are non-naturally occurring.

Non-limiting examples of types of engineering that can be done to obtain a non-naturally occurring nuclease system are as follows. Engineering can include codon optimization to facilitate expression or improve expression in a host cell, such as a heterologous host cell. Engineering can reduce the size or molecular weight of the nuclease in order to facilitate expression or delivery. Engineering can alter PAM selection in order to change PAM specificity or to broaden the range of recognized PAMs. Engineering can alter, increase, or decrease stability, processivity, specificity, or efficiency of a targetable nuclease system. Engineering can alter, increase, or decrease protein stability. Engineering can alter, increase, or decrease processivity of nucleic acid scanning. Engineering can alter, increase, or decrease target sequence specificity. Engineering can alter, increase, or decrease nuclease activity. Engineering can alter, increase, or decrease editing efficiency. Engineering can alter, increase, or decrease transformation efficiency. Engineering can alter, increase, or decrease nuclease or guide nucleic acid expression.

Examples of non-naturally occurring nucleic acid sequences which are disclosed herein include sequences codon optimized for expression in bacteria, such as E. coli (e.g., SEQ ID NO: 41-60), sequences codon optimized for expression in single cell eukaryotes, such as yeast (e.g., SEQ ID NO: 127-146), sequences codon optimized for expression in multi cell eukaryotes, such as human cells (e.g., SEQ ID NO: 147-166), polynucleotides used for cloning or expression of any sequences disclosed herein (e.g., SEQ ID NO: 61-80), plasmids comprising nucleic acid sequences (e.g., SEQ ID NO: 21-40) operably linked to a heterologous promoter or nuclear localization signal or other heterologous element, proteins generated from engineered or codon optimized nucleic acid sequences (e.g., SEQ ID NO: 1-20), or engineered guide nucleic acids comprising any one of SEQ ID NO: 84-107. Such non-naturally occurring nucleic acid sequences can be amplified, cloned, assembled, synthesized, generated from synthesized oligonucleotides or dNTPs, or otherwise obtained using methods known by those skilled in the art.

Disclosed herein are nucleic acid-guided nucleases. Subject nucleases are functional in vitro, or in prokaryotic, archaeal, or eukaryotic cells for in vitro, in vivo, or ex vivo applications. Suitable nucleic acid-guided nucleases can be from an organism from a genus which includes but is not limited to Thiomicrospira, Succinivibrio, Candidatus, Porphyromonas, Acidaminococcus, Acidomonococcus, Prevotella, Smithella, Moraxella, Synergistes, Francisella, Leptospira, Catenibacterium, Kandleria, Clostridium, Dorea, Coprococcus, Enterococcus, Fructobacillus, Weissella, Pediococcus, Corynebacter, Sutterella, Legionella, Treponema, Roseburia, Filifactor, Eubacterium, Streptococcus, Lactobacillus, Mycoplasma, Bacteroides, Flaviivola, Flavobacterium, Sphaerochaeta, Azospirillum, Gluconacetobacter, Neisseria, Roseburia, Parvibaculum, Staphylococcus, Nitratifractor, Mycoplasma, Alicyclobacillus, Brevibacilus, Bacillus, Bacteroidetes, Brevibacilus, Carnobacterium, Clostridiaridium, Clostridium, Desulfonatronum, Desulfovibrio, Helcococcus, Leptotrichia, Listeria, Methanomethyophilus, Methylobacterium, Opitutaceae, Paludibacter, Rhodobacter, Sphaerochaeta, Tuberibacillus, Oleiphilus, Omnitrophica, Parcubacteria, and Campylobacter. Species of organism of such a genus can be as otherwise herein discussed. Suitable nucleic acid-guided nucleases can be from an organism from a genus or unclassified genus within a kingdom which includes but is not limited to Firmicute, Actinobacteria, Bacteroidetes, Proteobacteria, Spirochates, and Tenericutes. Suitable nucleic acid-guided nucleases can be from an organism from a genus or unclassified genus within a phylum which includes but is not limited to Erysipelotrichia, Clostridia, Bacilli, Actinobacteria, Bacteroidetes, Flavobacteria, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Deltaproteobacteria, Epsilonproteobacteria, Spirochaetes, and Mollicutes. Suitable nucleic acid-guided nucleases can be from an organism from a genus or unclassified genus within an order which includes but is not limited to Clostridiales, Lactobacillales, Actinomycetales, Bacteroidales, Flavobacteriales, Rhizobiales, Rhodospirillales, Burkholderiales, Neisseriales, Legionellales, Nautiliales, Campylobacterales, Spirochaetales, Mycoplasmatales, and Thiotrichales. Suitable nucleic acid-guided nucleases can be from an organism from a genus or unclassified genus within a family which includes but is not limited to Lachnospiraceae, Enterococcaceae, Leuconostocaceae, Lactobacillaceae, Streptococcaceae, Peptostreptococcaceae, Staphylococcaceae, Eubacteriaceae, Corynebacterineae, Bacteroidaceae, Flavobacterium, Cryomoorphaceae, Rhodobiaceae, Rhodospirillaceae, Acetobacteraceae, Sutterellaceae, Neisseriaceae, Legionellaceae, Nautiliaceae, Campylobacteraceae, Spirochaetaceae, Mycoplasmataceae, Pisciririckettsiaceae, and Francisellaceae. Other nucleic acid-guided nucleases have been describe in US Patent Application Publication No. US20160208243 filed Dec. 18, 2015, US Application Publication No. US20140068797 filed Mar. 15, 2013, U.S. Pat. No. 8,697,359 filed Oct. 15, 2013, and Zetsche et al., Cell 2015 Oct. 22; 163(3):759-71, each of which are incorporated herein by reference in their entirety.

Some nucleic acid-guided nucleases suitable for use in the methods, systems, and compositions of the present disclosure include those derived from an organism such as, but not limited to, Thiomicrospira sp. XS5, Eubacterium rectale, Succinivibrio dextrinosolvens, Candidatus Methanoplasma termitum, Candidatus Methanomethylophilus alvus, Porphyromonas crevioricanis, Flavobacterium branchiophilum, Acidaminococcus Sp., Acidomonococcus sp., Lachnospiraceae bacterium COE1, Prevotella brevis ATCC 19188, Smithella sp. SCADC, Moraxella bovoculi, Synergistes jonesii, Bacteroidetes oral taxon 274, Francisella tularensis, Leptospira inadai serovar Lyme str. 10, Acidomonococcus sp. crystal structure (5B43) S. mutans, S. agalactiae, S. equisimilis, S. sanguinis, S. pneumonia; C. jejuni, C. coli; N. salsuginis, N. tergarcus; S. auricularis, S. carnosus; N. meningitides, N. gonorrhoeae; L. monocytogenes, L. ivanovii; C. botulinum, C. difficile, C. tetani, C. sordellii; Francisella tularensis 1, Prevotella albensis, Lachnospiraceae bacterium MC2017 1, Butyrivibrio proteoclasticus, Butyrivibrio proteoclasticus B316, Peregrinibacteria bacterium GW2011_GWA2_33_10, Parcubacteria bacterium GW2011_GWC2_44_17, Smithella sp. SCADC, Acidaminococcus sp. BV3L6, Lachnospiraceae bacterium MA2020, Candidatus Methanoplasma termitum, Eubacterium eligens, Moraxella bovoculi 237, Leptospira inadai, Lachnospiraceae bacterium ND2006, Porphyromonas crevioricanis 3, Prevotella disiens, Porphyromonas macacae, Catenibacterium sp. CAG:290, Kandleria vitulina, Clostridiales bacterium KA00274, Lachnospiraceae bacterium 3-2, Dorea longicatena, Coprococcus catus GD/7, Enterococcus columbae DSM 7374, Fructobacillus sp. EFB-N1, Weissella halotolerans, Pediococcus acidilactici, Lactobacillus curvatus, Streptococcus pyogenes, Lactobacillus versmoldensis, Filifactor alocis ATCC 35896, Alicyclobacillus acidoterrestris, Alicyclobacillus acidoterrestris ATCC 49025, Desulfovibrio inopinatus, Desulfovibrio inopinatus DSM 10711, Oleiphilus sp. Oleiphilus sp. HI0009, Candidtus kefeldibacteria, Parcubacteria CasY.4, Omnitrophica WOR 2 bacterium GWF2, Bacillus sp. NSP2.1, and Bacillus thermoamylovorans.

In some instances, a nucleic acid-guided nuclease disclosed herein comprises an amino acid sequence comprising at least 50% amino acid identity to any one of SEQ ID NO: 1-20. In some instances, a nuclease comprises an amino acid sequence comprising at least about 10%, 20%, 30%, 40%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% amino acid identity to any one of SEQ ID NO: 1-20. In some cases, the nucleic acid-guided nuclease comprises at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, amino acid identity to any one of SEQ ID NO: 1-20. In some cases, the nucleic acid-guided nuclease comprises at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, amino acid identity to any one of SEQ ID NO: 1-8 or 10-12. In some cases, the nucleic acid-guided nuclease comprises at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, amino acid identity to any one of SEQ ID NO: 1-8 or 10-11. In some cases, the nucleic acid-guided nuclease comprises at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, amino acid identity to SEQ ID NO: 2. In some cases, the nucleic acid-guided nuclease comprises at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, amino acid identity to SEQ ID NO: 7.

In some cases, the nucleic acid-guided nuclease comprises any one of SEQ ID NO: 1-20. In some cases, the nucleic acid-guided nuclease comprises any one of SEQ ID NO: 1-8 or 10-12. In some cases, the nucleic acid-guided nuclease comprises any one of SEQ ID NO: 1-8 or 10-11. In some cases, the nucleic acid-guided nuclease comprises SEQ ID NO: 2. In some cases, the nucleic acid-guided nuclease comprises SEQ ID NO: 7.

In some instances, a nucleic acid-guided nuclease comprises an amino acid sequence comprising at most 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% amino acid identity to any one of SEQ ID NO: 12 or SEQ ID NO: 108-110. In some instances, a nucleic acid-guided nuclease comprises an amino acid sequence comprising at most 50% amino acid identity to any one of SEQ ID NO: 12 or SEQ ID NO: 108-110. In some instances, a nucleic acid-guided nuclease comprises an amino acid sequence comprising at most 45% amino acid identity to any one of SEQ ID NO: 12 or SEQ ID NO: 108-110. In some instances, a nucleic acid-guided nuclease comprises an amino acid sequence comprising at most 40% amino acid identity to any one of SEQ ID NO: 12 or SEQ ID NO: 108-110. In some instances, a nucleic acid-guided nuclease comprises an amino acid sequence comprising at most 35% amino acid identity to any one of SEQ ID NO: 12 or SEQ ID NO: 108-110. In some instances, a nucleic acid-guided nuclease comprises an amino acid sequence comprising at most 30% amino acid identity to any one of SEQ ID NO: 12 or SEQ ID NO: 108-110.

In some instances, a nucleic acid-guided nuclease disclosed herein is encoded by a nucleic acid sequence comprising at least 50% sequence identity to any one of SEQ ID NO: 21-40. In some instances, a nuclease is encoded by a nucleic acid sequence comprising at least about 10%, 20%, 30%, 40%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% sequence identity to any one of SEQ ID NO: 21-40. In some instances, a nuclease is encoded by a nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, sequence identity to any one of SEQ ID NO: 21-40. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, sequence identity to any one of SEQ ID NO: 21-40. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, sequence identity to any one of SEQ ID NO: 21-28 or 30-32. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, sequence identity to any one of SEQ ID NO: 21-28 or 30-31. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, sequence identity to SEQ ID NO: 22. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, sequence identity to SEQ ID NO: 27.

In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 21-40. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 21-28 or 30-32. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 21-28 or 30-31. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 22. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 27.

In some instances, a nucleic acid-guided nuclease disclosed herein is encoded on a nucleic acid sequence. Such a nucleic acid can be codon optimized for expression in a desired host cell. Suitable host cells can include, as non-limiting examples, prokaryotic cells such as E. coli, P. aeruginosa, B. subtilus, and V. natriegens, and eukaryotic cells such as S. cerevisiae, plant cells, insect cells, nematode cells, amphibian cells, fish cells, or mammalian cells, including human cells.

A nucleic acid sequence encoding a nucleic acid-guided nuclease can be codon optimized for expression in gram positive bacteria, e.g., Bacillus subtilis, or gram negative bacteria, e.g., E. coli. In some instances, a nucleic acid-guided nuclease disclosed herein is encoded by a nucleic acid sequence comprising at least 50% sequence identity to any one of SEQ ID NO: 41-60. In some instances, a nuclease is encoded by a nucleic acid sequence comprising at least about 10%, 20%, 30%, 40%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% sequence identity to any one of SEQ ID NO: 41-60. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 41-60. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 41-48 or 50-52. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 41-48 or 50-51. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to SEQ ID NO: 42. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to SEQ ID NO: 47.

In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 41-60. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 41-48 or 50-52. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 41-48 or 50-51. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 42. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 47.

A nucleic acid sequence encoding a nucleic acid-guided nuclease can be codon optimized for expression in a species of yeast, e.g., S. cerevisiae. In some instances, a nucleic acid-guided nuclease disclosed herein is encoded by a nucleic acid sequence comprising at least 50% sequence identity to any one of SEQ ID NO: 127-146. In some instances, a nuclease is encoded by a nucleic acid sequence comprising at least about 10%, 20%, 30%, 40%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% sequence identity to any one of SEQ ID NO: 127-146. In some instances, a nuclease is encoded by a nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 127-146. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 127-146. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 127-134 or 136-138. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 127-134 or 136-137. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to SEQ ID NO: 128. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to SEQ ID NO: 133.

In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 127-146. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 127-134 or 136-138. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 127-134 or 136-137. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 128. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 133.

A nucleic acid sequence encoding a nucleic acid-guided nuclease can be codon optimized for expression in mammalian cells. In some instances, a nucleic acid-guided nuclease disclosed herein is encoded by a nucleic acid sequence comprising at least 50% sequence identity to any one of SEQ ID NO: 147-166. In some instances, a nuclease is encoded by a nucleic acid sequence comprising at least about 10%, 20%, 30%, 40%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% sequence identity to any one of SEQ ID NO: 147-166. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 147-166. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 147-154 or 156-158. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to any one of SEQ ID NO: 147-154 or 156-157. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to SEQ ID NO: 148. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence comprising at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95% sequence identity to SEQ ID NO: 153.

In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 147-166. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 147-154 or 156-158. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of any one of SEQ ID NO: 147-154 or 156-157. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 148. In some cases, the nucleic acid-guided nuclease is encoded by the nucleic acid sequence of SEQ ID NO: 153.

A nucleic acid sequence encoding a nucleic acid-guided nuclease can be operably linked to a promoter. Such nucleic acid sequences can be linear or circular. The nucleic acid sequences can be comprised on a larger linear or circular nucleic acid sequences that comprises additional elements such as an origin of replication, selectable or screenable marker, terminator, other components of a targetable nuclease system, such as a guide nucleic acid, or an editing or recorder cassette as disclosed herein. These larger nucleic acid sequences can be recombinant expression vectors, as are described in more detail later.

Guide Nucleic Acid

In general, a guide nucleic acid can complex with a compatible nucleic acid-guided nuclease and can hybridize with a target sequence, thereby directing the nuclease to the target sequence. A subject nucleic acid-guided nuclease capable of complexing with a guide nucleic acid can be referred to as a nucleic acid-guided nuclease that is compatible with the guide nucleic acid. Likewise, a guide nucleic acid capable of complexing with a nucleic acid-guided nuclease can be referred to as a guide nucleic acid that is compatible with the nucleic acid-guided nucleases.

A guide nucleic acid can be DNA. A guide nucleic acid can be RNA. A guide nucleic acid can comprise both DNA and RNA. A guide nucleic acid can comprise modified of non-naturally occurring nucleotides. In cases where the guide nucleic acid comprises RNA, the RNA guide nucleic acid can be encoded by a DNA sequence on a polynucleotide molecule such as a plasmid, linear construct, or editing cassette as disclosed herein.

A guide nucleic acid can comprise a guide sequence. A guide sequence is a polynucleotide sequence having sufficient complementarity with a target polynucleotide sequence to hybridize with the target sequence and direct sequence-specific binding of a complexed nucleic acid-guided nuclease to the target sequence. The degree of complementarity between a guide sequence and its corresponding target sequence, when optimally aligned using a suitable alignment algorithm, is about or more than about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or more. Optimal alignment may be determined with the use of any suitable algorithm for aligning sequences. In some embodiments, a guide sequence is about or more than about 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 75, or more nucleotides in length. In some embodiments, a guide sequence is less than about 75, 50, 45, 40, 35, 30, 25, 20 nucleotides in length. Preferably the guide sequence is 10-30 nucleotides long. The guide sequence can be 15-20 nucleotides in length. The guide sequence can be 15 nucleotides in length. The guide sequence can be 16 nucleotides in length. The guide sequence can be 17 nucleotides in length. The guide sequence can be 18 nucleotides in length. The guide sequence can be 19 nucleotides in length. The guide sequence can be 20 nucleotides in length.

A guide nucleic acid can comprise a scaffold sequence. In general, a “scaffold sequence” includes any sequence that has sufficient sequence to promote formation of a targetable nuclease complex, wherein the targetable nuclease complex comprises a nucleic acid-guided nuclease and a guide nucleic acid comprising a scaffold sequence and a guide sequence. Sufficient sequence within the scaffold sequence to promote formation of a targetable nuclease complex may include a degree of complementarity along the length of two sequence regions within the scaffold sequence, such as one or two sequence regions involved in forming a secondary structure. In some cases, the one or two sequence regions are comprised or encoded on the same polynucleotide. In some cases, the one or two sequence regions are comprised or encoded on separate polynucleotides. Optimal alignment may be determined by any suitable alignment algorithm, and may further account for secondary structures, such as self-complementarity within either the one or two sequence regions. In some embodiments, the degree of complementarity between the one or two sequence regions along the length of the shorter of the two when optimally aligned is about or more than about 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 97.5%, 99%, or higher. In some embodiments, at least one of the two sequence regions is about or more than about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 40, 50, or more nucleotides in length.

A scaffold sequence of a subject guide nucleic acid can comprise a secondary structure. A secondary structure can comprise a pseudoknot region. In some cases, binding kinetics of a guide nucleic acid to a nucleic acid-guided nuclease is determined in part by secondary structures within the scaffold sequence. In some cases, binding kinetics of a guide nucleic acid to a nucleic acid-guided nuclease is determined in part by nucleic acid sequence with the scaffold sequence.

A scaffold sequence can comprise the sequence of any one of SEQ ID NO: 84-107. A scaffold sequence can comprise the sequence of any one of SEQ ID NO: 84-103. A scaffold sequence can comprise the sequence of any one of SEQ ID NO: 84-91 or 93-95. A scaffold sequence can comprise the sequence of any one of SEQ ID NO: 88, 93, 94, or 95. A scaffold sequence can comprise the sequence of SEQ ID NO: 88. A scaffold sequence can comprise the sequence of SEQ ID NO: 93. A scaffold sequence can comprise the sequence of SEQ ID NO: 94. A scaffold sequence can comprise the sequence of SEQ ID NO: 95.

In some aspects, the invention provides a nuclease that binds to a guide nucleic acid comprising a conserved scaffold sequence. For example, the nucleic acid-guided nucleases for use in the present disclosure can bind to a conserved pseudoknot region as shown in FIG. 13A. Specifically, the nucleic acid-guided nucleases for use in the present disclosure can bind to a guide nucleic acid comprising a conserved pseudoknot region as shown in FIG. 13A. Certain nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-1 (SEQ ID NO: 172). Other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-3 (SEQ ID NO: 173). Still other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-4 (SEQ ID NO: 174). Other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-5 (SEQ ID NO: 175). Other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-6 (SEQ ID NO: 176). Still other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-7 (SEQ ID NO: 177). Other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-8 (SEQ ID NO: 178). Other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-10 (SEQ ID NO: 179). Still other nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-11 (SEQ ID NO: 180). Certain nucleic acid-guided nucleases for use in the present disclosure can bind to a pseudoknot region having at least 75%, 80%, 85%, 90%, 95%, or 100% sequence identity to the pseudoknot region of Scaffold-12 (SEQ ID NO: 181). Additional sequences in FIG. 13A include those for the consensus sequence (SEQ ID No: 190); frame 1 (SEQ ID No: 191); scaffold-1 (SEQ ID No: 192); scaffold-2 (SEQ ID No: 193); scaffold-3 (SEQ ID No: 194); scaffold-4 (SEQ ID No: 195); scaffold-5 (SEQ ID No: 196); scaffold-6 (SEQ ID No: 197); scaffold-7 (SEQ ID No: 198); scaffold-8 (SEQ ID No: 199); scaffold-10 (SEQ ID No: 200); scaffold-11 (SEQ ID No: 201); and scaffold-12 (SEQ ID No: 202).

A guide nucleic acid can comprise the sequence of any one of SEQ ID NO: 84-107. A guide nucleic acid can comprise the sequence of any one of SEQ ID NO: 84-103. A guide nucleic acid can comprise the sequence of any one of SEQ ID NO: 84-91 or 93-95. A guide nucleic acid can comprise the sequence of any one of SEQ ID NO: 88, 93, 94, or 95. A guide nucleic acid can comprise the sequence of SEQ ID NO: 88. A guide nucleic acid can comprise the sequence of SEQ ID NO: 93. A guide nucleic acid can comprise the sequence of SEQ ID NO: 94. A guide nucleic acid can comprise the sequence of SEQ ID NO: 95.

In aspects of the invention the terms “guide nucleic acid” refers to one or more polynucleotides comprising 1) a guide sequence capable of hybridizing to a target sequence and 2) a scaffold sequence capable of interacting with or complexing with an nucleic acid-guided nuclease as described herein. A guide nucleic acid may be provided as one or more nucleic acids. In specific embodiments, the guide sequence and the scaffold sequence are provided as a single polynucleotide.

A guide nucleic acid can be compatible with a nucleic acid-guided nuclease when the two elements can form a functional targetable nuclease complex capable of cleaving a target sequence. Often, a compatible scaffold sequence for a compatible guide nucleic acid can be found by scanning sequences adjacent to a native nucleic acid-guided nuclease loci. In other words, native nucleic acid-guided nucleases can be encoded on a genome within proximity to a corresponding compatible guide nucleic acid or scaffold sequence.

Nucleic acid-guided nucleases can be compatible with guide nucleic acids that are not found within the nucleases endogenous host. Such orthogonal guide nucleic acids can be determined by empirical testing. Orthogonal guide nucleic acids can come from different bacterial species or be synthetic or otherwise engineered to be non-naturally occurring.

Orthogonal guide nucleic acids that are compatible with a common nucleic acid-guided nuclease can comprise one or more common features. Common features can include sequence outside a pseudoknot region. Common features can include a pseudoknot region. Common features can include a primary sequence or secondary structure.

A guide nucleic acid can be engineered to target a desired target sequence by altering the guide sequence such that the guide sequence is complementary to the target sequence, thereby allowing hybridization between the guide sequence and the target sequence. A guide nucleic acid with an engineered guide sequence can be referred to as an engineered guide nucleic acid. Engineered guide nucleic acids are often non-naturally occurring and are not found in nature.

Targetable Nuclease System

Disclosed herein are targetable nuclease systems. A targetable nuclease system can comprise a nucleic acid-guided nuclease and a compatible guide nucleic acid. A targetable nuclease system can comprise a nucleic acid-guided nuclease or a polynucleotide sequence encoding the nucleic acid-guided nuclease. A targetable nuclease system can comprise a guide nucleic acid or a polynucleotide sequence encoding the guide nucleic acid.

In general, a targetable nuclease system as disclosed herein is characterized by elements that promote the formation of a targetable nuclease complex at the site of a target sequence, wherein the targetable nuclease complex comprises a nucleic acid-guided nuclease and a guide nucleic acid.

A guide nucleic acid together with a nucleic acid-guided nuclease forms a targetable nuclease complex which is capable of binding to a target sequence within a target polynucleotide, as determined by the guide sequence of the guide nucleic acid.

In general, to generate a double stranded break, in most cases a targetable nuclease complex binds to a target sequence as determined by the guide nucleic acid, and the nuclease has to recognize a protospacer adjacent motif (PAM) sequence adjacent to the target sequence.

A targetable nuclease complex can comprise a nucleic acid-guided nuclease of any one of SEQ ID NO: 1-20 and a compatible guide nucleic acid. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of any one of SEQ ID NO: 1-8 or 10-12 and a compatible guide nucleic acid. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of any one of SEQ ID NO: 1-8 or 10-11 and a compatible guide nucleic acid. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid. In any of these cases, the guide nucleic acid can comprise a scaffold sequence compatible with the nucleic acid-guided nuclease. In any of these cases, the guide nucleic acid can further comprise a guide sequence. The guide sequence can be engineered to target any desired target sequence. The guide sequence can be engineered to be complementary to any desired target sequence. The guide sequence can be engineered to hybridize to any desired target sequence.

A targetable nuclease complex can comprise a nucleic acid-guided nuclease of any one of SEQ ID NO: 1-20 and a compatible guide nucleic acid comprising any one of SEQ ID NO: 84-107. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of any one of SEQ ID NO: 1-8 or 10-12 and a compatible guide nucleic acid comprising any one of SEQ ID NO: 84-95. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of any one of SEQ ID NO: 1-8 or 10-11 and a compatible guide nucleic acid comprising any one of SEQ ID NO: 84-91 or 93-95. In any of these cases, the guide nucleic acid can further comprise a guide sequence. The guide sequence can be engineered to target any desired target sequence. The guide sequence can be engineered to be complementary to any desired target sequence. The guide sequence can be engineered to hybridize to any desired target sequence.

A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid comprising any one of SEQ ID NO: 88, 93, 94, or 95. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid comprising SEQ ID NO: 88. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid comprising SEQ ID NO: 93. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid comprising SEQ ID NO: 94. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 2 and a compatible guide nucleic acid comprising SEQ ID NO: 95. In any of these cases, the guide nucleic acid can further comprise a guide sequence. The guide sequence can be engineered to target any desired target sequence. The guide sequence can be engineered to be complementary to any desired target sequence. The guide sequence can be engineered to hybridize to any desired target sequence.

A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid comprising any one of SEQ ID NO: 88, 93, 94, or 95. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid comprising SEQ ID NO: 88. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid comprising SEQ ID NO: 93. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid comprising SEQ ID NO: 94. A targetable nuclease complex can comprise a nucleic acid-guided nuclease of SEQ ID NO: 7 and a compatible guide nucleic acid comprising SEQ ID NO: 95. In any of these cases, the guide nucleic acid can further comprise a guide sequence. The guide sequence can be engineered to target any desired target sequence. The guide sequence can be engineered to be complementary to any desired target sequence. The guide sequence can be engineered to hybridize to any desired target sequence.

A target sequence of a targetable nuclease complex can be any polynucleotide endogenous or exogenous to a prokaryotic or eukaryotic cell, or in vitro. For example, the target sequence can be a polynucleotide residing in the nucleus of the eukaryotic cell. A target sequence can be a sequence coding a gene product (e.g., a protein) or a non-coding sequence (e.g., a regulatory polynucleotide or a junk DNA). Without wishing to be bound by theory, it is believed that the target sequence should be associated with a PAM; that is, a short sequence recognized by a targetable nuclease complex. The precise sequence and length requirements for a PAM differ depending on the nucleic acid-guided nuclease used, but PAMs are typically 2-5 base pair sequences adjacent the target sequence. Examples of PAM sequences are given in the examples section below, and the skilled person will be able to identify further PAM sequences for use with a given nucleic acid-guided nuclease. Further, engineering of the PAM Interacting (PI) domain may allow programming of PAM specificity, improve target site recognition fidelity, and increase the versatility of a nucleic acid-guided nuclease genome engineering platform. Nucleic acid-guided nucleases may be engineered to alter their PAM specificity, for example as described in Kleinstiver B P et al. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 2015 Jul. 23; 523 (7561): 481-5. doi: 10.1038/nature14592.

A PAM site is a nucleotide sequence in proximity to a target sequence. In most cases, a nucleic acid-guided nuclease can only cleave a target sequence if an appropriate PAM is present. PAMs are nucleic acid-guided nuclease-specific and can be different between two different nucleic acid-guided nucleases. A PAM can be 5′ or 3′ of a target sequence. A PAM can be upstream or downstream of a target sequence. A PAM can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more nucleotides in length. Often, a PAM is between 2-6 nucleotides in length.

In some examples, a PAM can be provided on a separate oligonucleotide. In such cases, providing PAM on a oligonucleotide allows cleavage of a target sequence that otherwise would not be able to be cleave because no adjacent PAM is present on the same polynucleotide as the target sequence.

Polynucleotide sequences encoding a component of a targetable nuclease system can comprise one or more vectors. In general, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. Vectors include, but are not limited to, nucleic acid molecules that are single-stranded, double-stranded, or partially double-stranded; nucleic acid molecules that comprise one or more free ends, no free ends (e.g. circular); nucleic acid molecules that comprise DNA, RNA, or both; and other varieties of polynucleotides known in the art. One type of vector is a “plasmid,” which refers to a circular double stranded DNA loop into which additional DNA segments can be inserted, such as by standard molecular cloning techniques. Another type of vector is a viral vector, wherein virally-derived DNA or RNA sequences are present in the vector for packaging into a virus (e.g. retroviruses, replication defective retroviruses, adenoviruses, replication defective adenoviruses, and adeno-associated viruses). Viral vectors also include polynucleotides carried by a virus for transfection into a host cell. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g. bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively-linked. Such vectors are referred to herein as “expression vectors.” Common expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. Further discussion of vectors is provided herein.

Recombinant expression vectors can comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory elements, which may be selected on the basis of the host cells to be used for expression, that is operatively-linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory element(s) in a manner that allows for expression of the nucleotide sequence (e.g. in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). With regards to recombination and cloning methods, mention is made of U.S. patent application Ser. No. 10/815,730, published Sep. 2, 2004 as US 2004-0171156 A1, the contents of which are herein incorporated by reference in their entirety.

In some embodiments, a regulatory element is operably linked to one or more elements of a targetable nuclease system so as to drive expression of the one or more components of the targetable nuclease system.

In some embodiments, a vector comprises a regulatory element operably linked to a polynucleotide sequence encoding a nucleic acid-guided nuclease. The polynucleotide sequence encoding the nucleic acid-guided nuclease can be codon optimized for expression in particular cells, such as prokaryotic or eukaryotic cells. Eukaryotic cells can be yeast, fungi, algae, plant, animal, or human cells. Eukaryotic cells may be those of or derived from a particular organism, such as a mammal, including but not limited to human, mouse, rat, rabbit, dog, or non-human mammal including non-human primate.

In general, codon optimization refers to a process of modifying a nucleic acid sequence for enhanced expression in the host cells of interest by replacing at least one codon (e.g. about or more than about 1, 2, 3, 4, 5, 10, 15, 20, 25, 50, or more codons) of the native sequence with codons that are more frequently or most frequently used in the genes of that host cell while maintaining the native amino acid sequence. Various species exhibit particular bias for certain codons of a particular amino acid. Codon bias (differences in codon usage between organisms) often correlates with the efficiency of translation of messenger RNA (mRNA), which is in turn believed to be dependent on, among other things, the properties of the codons being translated and the availability of particular transfer RNA (tRNA) molecules. The predominance of selected tRNAs in a cell is generally a reflection of the codons used most frequently in peptide synthesis. Accordingly, genes can be tailored for optimal gene expression in a given organism based on codon optimization. Codon usage tables are readily available, for example, at the “Codon Usage Database” available at www.kazusa.orjp/codon/(visited Jul. 9, 2002), and these tables can be adapted in a number of ways. See Nakamura, Y., et al. “Codon usage tabulated from the international DNA sequence databases: status for the year 2000” Nucl. Acids Res. 28:292 (2000). Computer algorithms for codon optimizing a particular sequence for expression in a particular host cell are also available, such as Gene Forge (Aptagen; Jacobus, Pa.), are also available. In some embodiments, one or more codons (e.g. 1, 2, 3, 4, 5, 10, 15, 20, 25, 50, or more, or all codons) in a sequence encoding an engineered nuclease correspond to the most frequently used codon for a particular amino acid.

In some embodiments, a vector encodes a nucleic acid-guided nuclease comprising one or more nuclear localization sequences (NLSs), such as about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more NLSs. In some embodiments, the engineered nuclease comprises about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more NLSs at or near the amino-terminus, about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more NLSs at or near the carboxy-terminus, or a combination of these (e.g. one or more NLS at the amino-terminus and one or more NLS at the carboxy terminus). When more than one NLS is present, each may be selected independently of the others, such that a single NLS may be present in more than one copy and/or in combination with one or more other NLSs present in one or more copies. In a preferred embodiment of the invention, the engineered nuclease comprises at most 6 NLSs. In some embodiments, an NLS is considered near the N- or C-terminus when the nearest amino acid of the NLS is within about 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, or more amino acids along the polypeptide chain from the N- or C-terminus. Non-limiting examples of NLSs include an NLS sequence derived from: the NLS of the SV40 virus large T-antigen, having the amino acid sequence PKKKRKV (SEQ ID NO: 111); the NLS from nucleoplasmin (e.g. the nucleoplasmin bipartite NLS with the sequence KRPAATKKAGQAKKKK (SEQ ID NO:112)); the c-myc NLS having the amino acid sequence PAAKRVKLD (SEQ ID NO:113) or RQRRNELKRSP (SEQ ID NO:114); the hRNPA1 M9 NLS having the sequence NQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGY (SEQ ID NO: 115); the sequence RMRIZFKNKGKDTAELRRRRVEVSVELRKAKKDEQILKRRNV (SEQ ID NO:1 116) of the IBB domain from importin-alpha; the sequences VSRKRPRP (SEQ ID NO:117) and PPKKARED (SEQ ID NO:115) of the myoma T protein; the sequence PQPKKKPL (SEQ ID NO:119) of human p53; the sequence SALIKKKKKMAP (SEQ ID NO:120) of mouse c-abl IV; the sequences DRLRR (SEQ ID NO:121) and PKQKKRK (SEQ ID NO:122) of the influenza virus NS1; the sequence RKLKKKIKKL (SEQ ID NO:123) of the Hepatitis virus delta antigen; the sequence REKKKFLKRR (SEQ ID NO: 124) of the mouse Mx1 protein; the sequence KRKGDEVDGVDEVAKKKSKK (SEQ ID NO: 125) of the human poly(ADP-ribose) polymerase; and the sequence RKCLQAGMNLEARKTKK (SEQ ID NO: 126) of the steroid hormone receptors (human) glucocorticoid.

In general, the one or more NLSs are of sufficient strength to drive accumulation of the nucleic acid-guided nuclease in a detectable amount in the nucleus of a eukaryotic cell. In general, strength of nuclear localization activity may derive from the number of NLSs, the particular NLS(s) used, or a combination of these factors. Detection of accumulation in the nucleus may be performed by any suitable technique. For example, a detectable marker may be fused to the nucleic acid-guided nuclease, such that location within a cell may be visualized, such as in combination with a means for detecting the location of the nucleus (e.g. a stain specific for the nucleus such as DAPI). Cell nuclei may also be isolated from cells, the contents of which may then be analyzed by any suitable process for detecting protein, such as immunohistochemistry, Western blot, or enzyme activity assay. Accumulation in the nucleus may also be determined indirectly, such as by an assay for the effect of the nucleic acid-guided nuclease complex formation (e.g. assay for DNA cleavage or mutation at the target sequence, or assay for altered gene expression activity affected by targetable nuclease complex formation and/or nucleic acid-guided nuclease activity), as compared to a control not exposed to the nucleic acid-guided nuclease or targetable nuclease complex, or exposed to a nucleic acid-guided nuclease lacking the one or more NLSs.

A nucleic acid-guided nuclease and one or more guide nucleic acids can be delivered either as DNA or RNA. Delivery of an nucleic acid-guided nuclease and guide nucleic acid both as RNA (unmodified or containing base or backbone modifications) molecules can be used to reduce the amount of time that the nucleic acid-guided nuclease persist in the cell. This may reduce the level of off-target cleavage activity in the target cell. Since delivery of a nucleic acid-guided nuclease as mRNA takes time to be translated into protein, it might be advantageous to deliver the guide nucleic acid several hours following the delivery of the nucleic acid-guided nuclease mRNA, to maximize the level of guide nucleic acid available for interaction with the nucleic acid-guided nuclease protein. In other cases, the nucleic acid-guided nuclease mRNA and guide nucleic acid are delivered concomitantly. In other examples, the guide nucleic acid is delivered sequentially, such as 0.5, 1, 2, 3, 4, or more hours after the nucleic acid-guided nuclease mRNA.

In situations where guide nucleic acid amount is limiting, it may be desirable to introduce a nucleic acid-guided nuclease as mRNA and guide nucleic acid in the form of a DNA expression cassette with a promoter driving the expression of the guide nucleic acid. This way the amount of guide nucleic acid available will be amplified via transcription.

Guide nucleic acid in the form of RNA or encoded on a DNA expression cassette can be introduced into a host cell comprising an nucleic acid-guided nuclease encoded on a vector or chromosome. The guide nucleic acid may be provided in the cassette one or more polynucleotides, which may be contiguous or non-contiguous in the cassette. In specific embodiments, the guide nucleic acid is provided in the cassette as a single contiguous polynucleotide.

A variety of delivery systems can be used to introduce a nucleic acid-guided nuclease (DNA or RNA) and guide nucleic acid (DNA or RNA) into a host cell. These include the use of yeast systems, lipofection systems, microinjection systems, biolistic systems, virosomes, liposomes, immunoliposomes, polycations, lipid:nucleic acid conjugates, virions, artificial virions, viral vectors, electroporation, cell permeable peptides, nanoparticles, nanowires (Shalek et al., Nano Letters, 2012), exosomes. Molecular trojan horses liposomes (Pardridge et al., Cold Spring Harb Protoc; 2010; doi:10.1101/pdb.prot5407) may be used to deliver an engineered nuclease and guide nuclease across the blood brain barrier.

In some embodiments, a editing template is also provided. A editing template may be a component of a vector as described herein, contained in a separate vector, or provided as a separate polynucleotide, such as an oligonucleotide, linear polynucleotide, or synthetic polynucleotide. In some cases, a editing template is on the same polynucleotide as a guide nucleic acid. In some embodiments, a editing template is designed to serve as a template in homologous recombination, such as within or near a target sequence nicked or cleaved by a nucleic acid-guided nuclease as a part of a complex as disclosed herein. A editing template polynucleotide may be of any suitable length, such as about or more than about 10, 15, 20, 25, 50, 75, 100, 150, 200, 500, 1000, or more nucleotides in length. In some embodiments, the editing template polynucleotide is complementary to a portion of a polynucleotide comprising the target sequence. When optimally aligned, a editing template polynucleotide might overlap with one or more nucleotides of a target sequences (e.g. about or more than about 1, 5, 10, 15, 20, 25, 30, 35, 40, or more nucleotides). In some embodiments, when a editing template sequence and a polynucleotide comprising a target sequence are optimally aligned, the nearest nucleotide of the template polynucleotide is within about 1, 5, 10, 15, 20, 25, 50, 75, 100, 200, 300, 400, 500, 1000, 5000, 10000, or more nucleotides from the target sequence.

In many examples, an editing template comprises at least one mutation compared to the target sequence. An editing template can comprise an insertion, deletion, modification, or any combination thereof compared to the target sequence. Examples of some editing templates are described in more detail in a later section.

In some aspects, the invention provides methods comprising delivering one or more polynucleotides, such as or one or more vectors or linear polynucleotides as described herein, one or more transcripts thereof, and/or one or proteins transcribed therefrom, to a host cell. In some aspects, the invention further provides cells produced by such methods, and organisms comprising or produced from such cells. In some embodiments, an engineered nuclease in combination with (and optionally complexed with) a guide nucleic acid is delivered to a cell.

Conventional viral and non-viral based gene transfer methods can be used to introduce nucleic acids in cells, such as prokaryotic cells, eukaryotic cells, mammalian cells, or target tissues. Such methods can be used to administer nucleic acids encoding components of an engineered nucleic acid-guided nuclease system to cells in culture, or in a host organism. Non-viral vector delivery systems include DNA plasmids, RNA (e.g. a transcript of a vector described herein), naked nucleic acid, and nucleic acid complexed with a delivery vehicle, such as a liposome. Viral vector delivery systems include DNA and RNA viruses, which have either episomal or integrated genomes after delivery to the cell. For a review of gene therapy procedures, see Anderson, Science 256:808-813 (1992); Nabel & Feigner, TIBTECH 11:211-217 (1993); Mitani & Caskey, TIBTECH 11:162-166 (1993); Dillon. TIBTECH 11:167-175 (1993); Miller, Nature 357:455-460 (1992); Van Brunt, Biotechnology 6(10):1149-1154 (1988); Vigne, Restorative Neurology and Neuroscience 8:35-36 (1995); Kremer & Perricaudet, British Medical Bulletin 51(1):31-44 (1995); Haddada et al., in Current Topics in Microbiology and Immunology Doerfler and Bohm (eds) (1995); and Yu et al., Gene Therapy 1:13-26 (1994).

Methods of non-viral delivery of nucleic acids include lipofection, microinjection, biolistics, virosomes, liposomes, immunoliposomes, polycation or lipid:nucleic acid conjugates, naked DNA, artificial virions, and agent-enhanced uptake of DNA. Lipofection is described in e.g., U.S. Pat. Nos. 5,049,386, 4,946,787; and 4,897,355) and lipofection reagents are sold commercially (e.g., Transfectam™ and Lipofectin™). Cationic and neutral lipids that are suitable for efficient receptor-recognition lipofection of polynucleotides include those of Felgner, WO 91/17424; WO 91/16024. Delivery can be to cells (e.g. in vitro or ex vivo administration) or target tissues (e.g. in vivo administration).

The preparation of lipid:nucleic acid complexes, including targeted liposomes such as immunolipid complexes, is well known to one of skill in the art (see, e.g., Crystal, Science 270:404-410 (1995); Blaese et al., Cancer Gene Ther. 2:291-297 (1995); Behr et al., Bioconjugate Chem. 5:382-389 (1994); Remy et al., Bioconjugate Chem. 5:647-654 (1994); Gao et al., Gene Therapy 2:710-722 (1995); Ahmad et al., Cancer Res. 52:4817-4820 (1992); U.S. Pat. Nos. 4,186,183, 4,217,344, 4,235,871, 4,261,975, 4,485,054, 4,501,728, 4,774,085, 4,837,028, and 4,946,787).

The use of RNA or DNA viral based systems for the delivery of nucleic acids take advantage of highly evolved processes for targeting a virus to specific cells in culture or in the host and trafficking the viral payload to the nucleus or host cell genome. Viral vectors can be administered directly to cells in culture, patients (in vivo), or they can be used to treat cells in vitro, and the modified cells may optionally be administered to patients (ex vivo). Conventional viral based systems could include retroviral, lentivirus, adenoviral, adeno-associated and herpes simplex virus vectors for gene transfer. Integration in the host genome is possible with the retrovirus, lentivirus, and adeno-associated virus gene transfer methods, often resulting in long term expression of the inserted transgene. Additionally, high transduction efficiencies have been observed in many different cell types and target tissues.

The tropism of a retrovirus can be altered by incorporating foreign envelope proteins, expanding the potential target population of target cells. Lentiviral vectors are retroviral vectors that are able to transduce or infect non-dividing cells and typically produce high viral titers. Selection of a retroviral gene transfer system would therefore depend on the target tissue. Retroviral vectors are comprised of cis-acting long terminal repeats with packaging capacity for up to 6-10 kb of foreign sequence. The minimum cis-acting LTRs are sufficient for replication and packaging of the vectors, which are then used to integrate the therapeutic gene into the target cell to provide permanent transgene expression. Widely used retroviral vectors include those based upon murine leukemia virus (MuLV), gibbon ape leukemia virus (GaLV), Simian Immuno deficiency virus (SIV), human immuno deficiency virus (HIV), and combinations thereof (see, e.g., Buchscher et al., J. Virol. 66:2731-2739 (1992); Johann et al., J. Virol. 66:1635-1640 (1992); Sommnerfelt et al., Virol. 176:58-59 (1990); Wilson et al., J. Virol. 63:2374-2378 (1989); Miller et al., J. Virol. 65:2220-2224 (1991); PCT/US94/05700).

In applications where transient expression is preferred, adenoviral based systems may be used. Adenoviral based vectors are capable of very high transduction efficiency in many cell types and do not require cell division. With such vectors, high titer and levels of expression have been obtained. This vector can be produced in large quantities in a relatively simple system.

Adeno-associated virus (“AAV”) vectors may also be used to transduce cells with target nucleic acids, e.g., in the in vitro production of nucleic acids and peptides, and for in vivo and ex vivo gene therapy procedures (see, e.g., West et al., Virology 160:38-47 (1987); U.S. Pat. No. 4,797,368; WO 93/24641; Kotin, Human Gene Therapy 5:793-801 (1994); Muzyczka, J. Clin. Invest. 94:1351 (1994). Construction of recombinant AAV vectors are described in a number of publications, including U.S. Pat. No. 5,173,414; Tratschin et al., Mol. Cell. Biol. 5:3251-3260 (1985); Tratschin, et al., Mol. Cell. Biol. 4:2072-2081 (1984); Hermonat & Muzyczka, PNAS 81:6466-6470 (1984); and Samulski et al., J. Virol. 63:03822-3828 (1989).

In some embodiments, a host cell is transiently or non-transiently transfected with one or more vectors, linear polynucleotides, polypeptides, nucleic acid-protein complexes, or any combination thereof as described herein. In some embodiments, a cell in transfected in vitro, in culture, or ex vivo. In some embodiments, a cell is transfected as it naturally occurs in a subject. In some embodiments, a cell that is transfected is taken from a subject. In some embodiments, the cell is derived from cells taken from a subject, such as a cell line.

In some embodiments, a cell transfected with one or more vectors, linear polynucleotides, polypeptides, nucleic acid-protein complexes, or any combination thereof as described herein is used to establish a new cell line comprising one or more transfection-derived sequences. In some embodiments, a cell transiently transfected with the components of an engineered nucleic acid-guided nuclease system as described herein (such as by transient transfection of one or more vectors, or transfection with RNA), and modified through the activity of an engineered nuclease complex, is used to establish a new cell line comprising cells containing the modification but lacking any other exogenous sequence.

In some embodiments, one or more vectors described herein are used to produce a non-human transgenic cell, organism, animal, or plant. In some embodiments, the transgenic animal is a mammal, such as a mouse, rat, or rabbit. Methods for producing transgenic cells, organisms, plants, and animals are known in the art, and generally begin with a method of cell transformation or transfection, such as described herein.

Methods of Use

In the context of formation of an engineered nuclease complex, “target sequence” refers to a sequence to which a guide sequence is designed to have complementarity, where hybridization between a target sequence and a guide sequence promotes the formation of a engineered nuclease complex. A target sequence may comprise any polynucleotide, such as DNA, RNA, or a DNA-RNA hybrid. A target sequence can be located in the nucleus or cytoplasm of a cell. A target sequence can be located in vitro or in a cell-free environment.

Typically, formation of an engineered nuclease complex comprising a guide nucleic acid hybridized to a target sequence and complexed with one or more engineered nucleases as disclosed herein results in cleavage of one or both strands in or near (e.g. within 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 50, or more base pairs from) the target sequence. Cleavage can occur within a target sequence, 5′ of the target sequence, upstream of a target sequence, 3′ of the target sequence, or downstream of a target sequence.

In some embodiments, one or more vectors driving expression of one or more components of a targetable nuclease system are introduced into a host cell or in vitro such formation of a targetable nuclease complex at one or more target sites. For example, a nucleic acid-guided nuclease and a guide nucleic acid could each be operably linked to separate regulatory elements on separate vectors. Alternatively, two or more of the elements expressed from the same or different regulatory elements, may be combined in a single vector, with one or more additional vectors providing any components of the targetable nuclease system not included in the first vector. Targetable nuclease system elements that are combined in a single vector may be arranged in any suitable orientation, such as one element located 5′ with respect to (“upstream” of) or 3′ with respect to (“downstream” of) a second element. The coding sequence of one element may be located on the same or opposite strand of the coding sequence of a second element, and oriented in the same or opposite direction. In some embodiments, a single promoter drives expression of a transcript encoding a nucleic acid-guided nuclease and one or more guide nucleic acids. In some embodiments, a nucleic acid-guided nuclease and one or more guide nucleic acids are operably linked to and expressed from the same promoter. In other embodiments, one or more guide nucleic acids or polynucleotides encoding the one or more guide nucleic acids are introduced into a cell or in vitro environment already comprising a nucleic acid-guided nuclease or polynucleotide sequence encoding the nucleic acid-guided nuclease.

When multiple different guide sequences are used, a single expression construct may be used to target nuclease activity to multiple different, corresponding target sequences within a cell or in vitro. For example, a single vector may comprise about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, or more guide sequences. In some embodiments, about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more such guide-sequence-containing vectors may be provided, and optionally delivered to a cell or in vitro.

Methods and compositions disclosed herein may comprise more than one guide nucleic acid, wherein each guide nucleic acid has a different guide sequence, thereby targeting a different target sequence. In such cases, multiple guide nucleic acids can be using in multiplexing, wherein multiple targets are targeted simultaneously. Additionally or alternatively, the multiple guide nucleic acids are introduced into a population of cells, such that each cell in a population received a different or random guide nucleic acid, thereby targeting multiple different target sequences across a population of cells. In such cases, the collection of subsequently altered cells can be referred to as a library.

Methods and compositions disclosed herein may comprise multiple different nucleic acid-guided nucleases, each with one or more different corresponding guide nucleic acids, thereby allowing targeting of different target sequences by different nucleic acid-guided nucleases. In some such cases, each nucleic acid-guided nuclease can correspond to a distinct plurality of guide nucleic acids, allowing two or more non overlapping, partially overlapping, or completely overlapping multiplexing events.

In some embodiments, the nucleic acid-guided nuclease has DNA cleavage activity or RNA cleavage activity. In some embodiments, the nucleic acid-guided nuclease directs cleavage of one or both strands at the location of a target sequence, such as within the target sequence and/or within the complement of the target sequence. In some embodiments, the nucleic acid-guided nuclease directs cleavage of one or both strands within about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 50, 100, 200, 500, or more base pairs from the first or last nucleotide of a target sequence.

In some embodiments, a nucleic acid-guided nuclease may form a component of an inducible system. The inducible nature of the system would allow for spatiotemporal control of gene editing or gene expression using a form of energy. The form of energy may include but is not limited to electromagnetic radiation, sound energy, chemical energy, light energy, temperature, and thermal energy. Examples of inducible system include tetracycline inducible promoters (Tet-On or Tet-Off), small molecule two-hybrid transcription activations systems (FKBP, ABA, etc), or light inducible systems (Phytochrome, LOV domains, or cryptochorome). In one embodiment, the nucleic acid-guided nuclease may be a part of a Light Inducible Transcriptional Effector (LITE) to direct changes in transcriptional activity in a sequence-specific manner. The components of a light inducible system may include a nucleic acid-guided nuclease, a light-responsive cytochrome heterodimer (e.g. from Arabidopsis thaliana), and a transcriptional activation/repression domain. Further examples of inducible DNA binding proteins and methods for their use are provided in U.S. 61/736,465 and U.S. 61/721,283, which is hereby incorporated by reference in its entirety. An inducible system can be temperature inducible such that the system is turned on or off by increasing or decreasing the temperature. In some temperature inducible systems, increasing the temperature turns the system on. In some temperature inducible systems, increasing the temperature turns the system off.

In some aspects, the invention provides for methods of modifying a target sequence in vitro, or in a prokaryotic or eukaryotic cell, which may be in vivo, ex vivo, or in vitro. In some embodiments, the method comprises sampling a cell or population of cells such as prokaryotic cells, or those from a human or non-human animal or plant (including micro-algae), and modifying the cell or cells. Culturing may occur at any stage in vitro or ex vivo. The cell or cells may even be re-introduced into the host, such as a non-human animal or plant (including micro-algae). For re-introduced cells it is particularly preferred that the cells are stem cells.

In some embodiments, the method comprises allowing a targetable nuclease complex to bind to the target sequence to effect cleavage of said target sequence, thereby modifying the target sequence, wherein the targetable nuclease complex comprises a nucleic acid-guided nuclease complexed with a guide nucleic acid wherein the guide sequence of the guide nucleic acid is hybridized to a target sequence within a target polynucleotide.

In some aspects, the invention provides a method of modifying expression of a target polynucleotide in in vitro or in a prokaryotic or eukaryotic cell. In some embodiments, the method comprises allowing a targetable nuclease complex to bind to a target sequence with the target polynucleotide such that said binding results in increased or decreased expression of said target polynucleotide; wherein the targetable nuclease complex comprises an nucleic acid-guided nuclease complexed with a guide nucleic acid, and wherein the guide sequence of the guide nucleic acid is hybridized to a target sequence within said target polynucleotide. Similar considerations apply as above for methods of modifying a target polynucleotide. In fact, these sampling, culturing and re-introduction options apply across the aspects of the present invention.

In some aspects, the invention provides kits containing any one or more of the elements disclosed in the above methods and compositions. Elements may provide individually or in combinations, and may be provided in any suitable container, such as a vial, a bottle, or a tube. In some embodiments, the kit includes instructions in one or more languages, for example in more than one language.

In some embodiments, a kit comprises one or more reagents for use in a process utilizing one or more of the elements described herein. Reagents may be provided in any suitable container. For example, a kit may provide one or more reaction or storage buffers. Reagents may be provided in a form that is usable in a particular assay, or in a form that requires addition of one or more other components before use (e.g. in concentrate or lyophilized form). A buffer can be any buffer, including but not limited to a sodium carbonate buffer, a sodium bicarbonate buffer, a borate buffer, a Tris buffer, a MOPS buffer, a HEPES buffer, and combinations thereof. In some embodiments, the buffer is alkaline. In some embodiments, the buffer has a pH from about 7 to about 10. In some embodiments, the kit comprises one or more oligonucleotides corresponding to a guide sequence for insertion into a vector so as to operably link the guide sequence and a regulatory element. In some embodiments, the kit comprises a editing template.

In some aspects, the invention provides methods for using one or more elements of a engineered targetable nuclease system. A targetable nuclease complex of the disclosure provides an effective means for modifying a target sequence within a target polynucleotide. A targetable nuclease complex of the disclosure has a wide variety of utility including modifying (e.g., deleting, inserting, translocating, inactivating, activating) a target sequence in a multiplicity of cell types. As such a targetable nuclease complex of the invention has a broad spectrum of applications in, e.g., biochemical pathway optimization, genome-wide studies, genome engineering, gene therapy, drug screening, disease diagnosis, and prognosis. An exemplary targetable nuclease complex comprises a nucleic acid-guided nuclease as disclosed herein complexed with a guide nucleic acid, wherein the guide sequence of the guide nucleic acid can hybridize to a target sequence within the target polynucleotide. A guide nucleic acid can comprise a guide sequence linked to a scaffold sequence. A scaffold sequence can comprise one or more sequence regions with a degree of complementarity such that together they form a secondary structure. In some cases, the one or more sequence regions are comprised or encoded on the same polynucleotide. In some cases, the one or more sequence regions are comprised or encoded on separate polynucleotides.

Provided herein are methods of cleaving a target polynucleotide. The method comprises cleaving a target polynucleotide using a targetable nuclease complex that binds to a target sequence within a target polynucleotide and effect cleavage of said target polynucleotide. Typically, the targetable nuclease complex of the invention, when introduced into a cell, creates a break (e.g., a single or a double strand break) in the target sequence. For example, the method can be used to cleave a target gene in a cell, or to replace a wildtype sequence with a modified sequence.

The break created by the targetable nuclease complex can be repaired by a repair process such as the error prone non-homologous end joining (NHEJ) pathway, the high fidelity homology-directed repair (HDR), or by recombination pathways. During these repair processes, an editing template can be introduced into the genome sequence. In some methods, the HDR or recombination process is used to modify a target sequence. For example, an editing template comprising a sequence to be integrated flanked by an upstream sequence and a downstream sequence is introduced into a cell. The upstream and downstream sequences share sequence similarity with either side of the site of integration in the chromosome, target vector, or target polynucleotide.

An editing template can be DNA or RNA, e.g., a DNA plasmid, a bacterial artificial chromosome (BAC), a yeast artificial chromosome (YAC), a viral vector, a linear piece of DNA, a PCR fragment, oligonucleotide, synthetic polynucleotide, a naked nucleic acid, or a nucleic acid complexed with a delivery vehicle such as a liposome or poloxamer.

An editing template polynucleotide can comprise a sequence to be integrated (e.g, a mutated gene). A sequence for integration may be a sequence endogenous or exogenous to the cell. Examples of a sequence to be integrated include polynucleotides encoding a protein or a non-coding RNA (e.g., a microRNA). Thus, the sequence for integration may be operably linked to an appropriate control sequence or sequences. Alternatively, the sequence to be integrated may provide a regulatory function. Sequence to be integrated may be a mutated or variant of an endogenous wildtype sequence. Alternatively, sequence to be integrated may be a wildtype version of an endogenous mutated sequence. Additionally or alternatively, sequenced to be integrated may be a variant or mutated form of an endogenous mutated or variant sequence.

Upstream and downstream sequences in an editing template polynucleotide can be selected to promote recombination between the target polynucleotide of interest and the editing template polynucleotide. The upstream sequence can be a nucleic acid sequence having sequence similarity with the sequence upstream of the targeted site for integration. Similarly, the downstream sequence can be a nucleic acid sequence having similarity with the sequence downstream of the targeted site of integration. The upstream and downstream sequences in an editing template can have 75%, 80%, 85%, 90%, 95%, or 100% sequence identity with the targeted polynucleotide. Preferably, the upstream and downstream sequences in the editing template polynucleotide have about 95%, 96%, 97%, 98%, 99%, or 100% sequence identity with the targeted polynucleotide. In some methods, the upstream and downstream sequences in the editing template polynucleotide have about 99% or 100% sequence identity with the targeted polynucleotide.

An upstream or downstream sequence may comprise from about 20 bp to about 2500 bp, for example, about 50, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, or 2500 bp. In some methods, the exemplary upstream or downstream sequence has about 15 bp to about 50 bp, about 30 bp to about 100 bp, about 200 bp to about 2000 bp, about 600 bp to about 1000 bp, or more particularly about 700 bp to about 1000 bp.

In some methods, the editing template polynucleotide may further comprise a marker. Such a marker may make it easy to screen for targeted integrations. Examples of suitable markers include restriction sites, fluorescent proteins, or selectable markers. The exogenous polynucleotide template of the invention can be constructed using recombinant techniques (see, for example, Green and Sambrook et al., 2014 and Ausubel et al., 2017).

In an exemplary method for modifying a target polynucleotide by integrating an editing template polynucleotide, a double stranded break is introduced into the genome sequence by an engineered nuclease complex, the break can be repaired via homologous recombination using an editing template such that the template is integrated into the target polynucleotide. The presence of a double-stranded break can increase the efficiency of integration of the editing template.

Disclosed herein are methods for modifying expression of a polynucleotide in a cell. Some methods comprise increasing or decreasing expression of a target polynucleotide by using a targetable nuclease complex that binds to the target polynucleotide.

In some methods, a target polynucleotide can be inactivated to effect the modification of the expression in a cell. For example, upon the binding of a targetable nuclease complex to a target sequence in a cell, the target polynucleotide is inactivated such that the sequence is not transcribed, the coded protein is not produced, or the sequence does not function as the wild-type sequence does. For example, a protein or microRNA coding sequence may be inactivated such that the protein is not produced.

In some methods, a control sequence can be inactivated such that it no longer functions as a regulatory sequence. As used herein, “regulatory sequence” can refer to any nucleic acid sequence that effects the transcription, translation, or accessibility of a nucleic acid sequence. Examples of regulatory sequences include, a promoter, a transcription terminator, and an enhancer.

An inactivated target sequence may include a deletion mutation (i.e., deletion of one or more nucleotides), an insertion mutation (i.e., insertion of one or more nucleotides), or a nonsense mutation (i.e., substitution of a single nucleotide for another nucleotide such that a stop codon is introduced). In some methods, the inactivation of a target sequence results in “knockout” of the target sequence.

An altered expression of one or more target polynucleotides associated with a signaling biochemical pathway can be determined by assaying for a difference in the mRNA levels of the corresponding genes between the test model cell and a control cell, when they are contacted with a candidate agent. Alternatively, the differential expression of the sequences associated with a signaling biochemical pathway is determined by detecting a difference in the level of the encoded polypeptide or gene product.

To assay for an agent-induced alteration in the level of mRNA transcripts or corresponding polynucleotides, nucleic acid contained in a sample is first extracted according to standard methods in the art. For instance, mRNA can be isolated using various lytic enzymes or chemical solutions according to the procedures set forth in Green and Sambrook (2014), or extracted by nucleic-acid-binding resins following the accompanying instructions provided by the manufacturers. The mRNA contained in the extracted nucleic acid sample is then detected by amplification procedures or conventional hybridization assays (e.g. Northern blot analysis) according to methods widely known in the art or based on the methods exemplified herein.

For purpose of this invention, amplification means any method employing a primer and a polymerase capable of replicating a target sequence with reasonable fidelity. Amplification may be carried out by natural or recombinant DNA polymerases such as TaqGold™, T7 DNA polymerase, Klenow fragment of E. coli DNA polymerase, and reverse transcriptase. A preferred amplification method is PCR. In particular, the isolated RNA can be subjected to a reverse transcription assay that is coupled with a quantitative polymerase chain reaction (RT-PCR) in order to quantify the expression level of a sequence associated with a signaling biochemical pathway.

Detection of the gene expression level can be conducted in real time in an amplification assay. In one aspect, the amplified products can be directly visualized with fluorescent DNA-binding agents including but not limited to DNA intercalators and DNA groove binders. Because the amount of the intercalators incorporated into the double-stranded DNA molecules is typically proportional to the amount of the amplified DNA products, one can conveniently determine the amount of the amplified products by quantifying the fluorescence of the intercalated dye using conventional optical systems in the art. DNA-binding dye suitable for this application include SYBR green, SYBR blue, DAPI, propidium iodine, Hoeste, SYBR gold, ethidium bromide, acridines, proflavine, acridine orange, acriflavine, fluorcoumanin, ellipticine, daunomycin, chloroquine, distamycin D, chromomycin, homidium, mithramycin, ruthenium polypyridyls, anthramycin, and the like.

In another aspect, other fluorescent labels such as sequence specific probes can be employed in the amplification reaction to facilitate the detection and quantification of the amplified products. Probe-based quantitative amplification relies on the sequence-specific detection of a desired amplified product. It utilizes fluorescent, target-specific probes (e.g., TaqMan™ probes) resulting in increased specificity and sensitivity. Methods for performing probe-based quantitative amplification are well established in the art and are taught in U.S. Pat. No. 5,210,015.

In yet another aspect, conventional hybridization assays using hybridization probes that share sequence homology with sequences associated with a signaling biochemical pathway can be performed. Typically, probes are allowed to form stable complexes with the sequences associated with a signaling biochemical pathway contained within the biological sample derived from the test subject in a hybridization reaction. It will be appreciated by one of skill in the art that where antisense is used as the probe nucleic acid, the target polynucleotides provided in the sample are chosen to be complementary to sequences of the antisense nucleic acids. Conversely, where the nucleotide probe is a sense nucleic acid, the target polynucleotide is selected to be complementary to sequences of the sense nucleic acid.

Hybridization can be performed under conditions of various stringency, for instance as described herein. Suitable hybridization conditions for the practice of the present invention are such that the recognition interaction between the probe and sequences associated with a signaling biochemical pathway is both sufficiently specific and sufficiently stable. Conditions that increase the stringency of a hybridization reaction are widely known and published in the art. See, for example, (Green and Sambrook, et al., (2014); Nonradioactive in Situ Hybridization Application Manual, Boehringer Mannheim, second edition). The hybridization assay can be formed using probes immobilized on any solid support, including but are not limited to nitrocellulose, glass, silicon, and a variety of gene arrays. A preferred hybridization assay is conducted on high-density gene chips as described in U.S. Pat. No. 5,445,934.

For a convenient detection of the probe-target complexes formed during the hybridization assay, the nucleotide probes are conjugated to a detectable label. Detectable labels suitable for use in the present invention include any composition detectable by photochemical, biochemical, spectroscopic, immunochemical, electrical, optical or chemical means. A wide variety of appropriate detectable labels are known in the art, which include fluorescent or chemiluminescent labels, radioactive isotope labels, enzymatic or other ligands. In preferred embodiments, one will likely desire to employ a fluorescent label or an enzyme tag, such as digoxigenin, .beta.-galactosidase, urease, alkaline phosphatase or peroxidase, avidin/biotin complex.

Detection methods used to detect or quantify the hybridization intensity will typically depend upon the label selected above. For example, radiolabels may be detected using photographic film or a phosphoimager. Fluorescent markers may be detected and quantified using a photodetector to detect emitted light. Enzymatic labels are typically detected by providing the enzyme with a substrate and measuring the reaction product produced by the action of the enzyme on the substrate; and finally colorimetric labels are detected by simply visualizing the colored label.

An agent-induced change in expression of sequences associated with a signaling biochemical pathway can also be determined by examining the corresponding gene products. Determining the protein level typically involves a) contacting the protein contained in a biological sample with an agent that specifically bind to a protein associated with a signaling biochemical pathway; and (b) identifying any agent:protein complex so formed. In one aspect of this embodiment, the agent that specifically binds a protein associated with a signaling biochemical pathway is an antibody, preferably a monoclonal antibody.

The reaction can be performed by contacting the agent with a sample of the proteins associated with a signaling biochemical pathway derived from the test samples under conditions that will allow a complex to form between the agent and the proteins associated with a signaling biochemical pathway. The formation of the complex can be detected directly or indirectly according to standard procedures in the art. In the direct detection method, the agents are supplied with a detectable label and unreacted agents may be removed from the complex; the amount of remaining label thereby indicating the amount of complex formed. For such method, it is preferable to select labels that remain attached to the agents even during stringent washing conditions. It is preferable that the label does not interfere with the binding reaction. In the alternative, an indirect detection procedure may use an agent that contains a label introduced either chemically or enzymatically. A desirable label generally does not interfere with binding or the stability of the resulting agent:polypeptide complex. However, the label is typically designed to be accessible to an antibody for an effective binding and hence generating a detectable signal.

A wide variety of labels suitable for detecting protein levels are known in the art. Non-limiting examples include radioisotopes, enzymes, colloidal metals, fluorescent compounds, bioluminescent compounds, and chemiluminescent compounds.

The amount of agent:polypeptide complexes formed during the binding reaction can be quantified by standard quantitative assays. As illustrated above, the formation of agent:polypeptide complex can be measured directly by the amount of label remained at the site of binding. In an alternative, the protein associated with a signaling biochemical pathway is tested for its ability to compete with a labeled analog for binding sites on the specific agent. In this competitive assay, the amount of label captured is inversely proportional to the amount of protein sequences associated with a signaling biochemical pathway present in a test sample.

A number of techniques for protein analysis based on the general principles outlined above are available in the art. They include but are not limited to radioimmunoassays, ELISA (enzyme linked immunoradiometric assays), “sandwich” immunoassays, immunoradiometric assays, in situ immunoassays (using e.g., colloidal gold, enzyme or radioisotope labels), western blot analysis, immunoprecipitation assays, immunofluorescent assays, and SDS-PAGE.

Antibodies that specifically recognize or bind to proteins associated with a signaling biochemical pathway are preferable for conducting the aforementioned protein analyses. Where desired, antibodies that recognize a specific type of post-translational modifications (e.g., signaling biochemical pathway inducible modifications) can be used. Post-translational modifications include but are not limited to glycosylation, lipidation, acetylation, and phosphorylation. These antibodies may be purchased from commercial vendors. For example, anti-phosphotyrosine antibodies that specifically recognize tyrosine-phosphorylated proteins are available from a number of vendors including Invitrogen and Perkin Elmer. Anti-phosphotyrosine antibodies are particularly useful in detecting proteins that are differentially phosphorylated on their tyrosine residues in response to an ER stress. Such proteins include but are not limited to eukaryotic translation initiation factor 2 alpha (eIF-2.alpha.). Alternatively, these antibodies can be generated using conventional polyclonal or monoclonal antibody technologies by immunizing a host animal or an antibody-producing cell with a target protein that exhibits the desired post-translational modification.

In practicing a subject method, it may be desirable to discern the expression pattern of an protein associated with a signaling biochemical pathway in different bodily tissue, in different cell types, and/or in different subcellular structures. These studies can be performed with the use of tissue-specific, cell-specific or subcellular structure specific antibodies capable of binding to protein markers that are preferentially expressed in certain tissues, cell types, or subcellular structures.

An altered expression of a gene associated with a signaling biochemical pathway can also be determined by examining a change in activity of the gene product relative to a control cell. The assay for an agent-induced change in the activity of a protein associated with a signaling biochemical pathway will dependent on the biological activity and/or the signal transduction pathway that is under investigation. For example, where the protein is a kinase, a change in its ability to phosphorylate the downstream substrate(s) can be determined by a variety of assays known in the art. Representative assays include but are not limited to immunoblotting and immunoprecipitation with antibodies such as anti-phosphotyrosine antibodies that recognize phosphorylated proteins. In addition, kinase activity can be detected by high throughput chemiluminescent assays such as AlphaScreen™ (available from Perkin Elmer) and eTag™ assay (Chan-Hui, et al. (2003) Clinical Immunology 111: 162-174).

Where the protein associated with a signaling biochemical pathway is part of a signaling cascade leading to a fluctuation of intracellular pH condition, pH sensitive molecules such as fluorescent pH dyes can be used as the reporter molecules. In another example where the protein associated with a signaling biochemical pathway is an ion channel, fluctuations in membrane potential and/or intracellular ion concentration can be monitored. A number of commercial kits and high-throughput devices are particularly suited for a rapid and robust screening for modulators of ion channels. Representative instruments include FLIPR™ (Molecular Devices, Inc.) and VIPR (Aurora Biosciences). These instruments are capable of detecting reactions in over 1000 sample wells of a microplate simultaneously, and providing real-time measurement and functional data within a second or even a minisecond.

In practicing any of the methods disclosed herein, a suitable vector can be introduced to a cell, tissue, organism, or an embryo via one or more methods known in the art, including without limitation, microinjection, electroporation, sonoporation, biolistics, calcium phosphate-mediated transfection, cationic transfection, liposome transfection, dendrimer transfection, heat shock transfection, nucleofection transfection, magnetofection, lipofection, impalefection, optical transfection, proprietary agent-enhanced uptake of nucleic acids, and delivery via liposomes, immunoliposomes, virosomes, or artificial virions. In some methods, the vector is introduced into an embryo by microinjection. The vector or vectors may be microinjected into the nucleus or the cytoplasm of the embryo. In some methods, the vector or vectors may be introduced into a cell by nucleofection.

A target polynucleotide of a targetable nuclease complex can be any polynucleotide endogenous or exogenous to the host cell. For example, the target polynucleotide can be a polynucleotide residing in the nucleus of the eukaryotic cell, the genome of a prokaryotic cell, or an extrachromosomal vector of a host cell. The target polynucleotide can be a sequence coding a gene product (e.g., a protein) or a non-coding sequence (e.g., a regulatory polynucleotide or a junk DNA).

Examples of target polynucleotides include a sequence associated with a signaling biochemical pathway, e.g., a signaling biochemical pathway-associated gene or polynucleotide. Examples of target polynucleotides include a disease associated gene or polynucleotide. A “disease-associated” gene or polynucleotide refers to any gene or polynucleotide which is yielding transcription or translation products at an abnormal level or in an abnormal form in cells derived from a disease-affected tissues compared with tissues or cells of a non-disease control. It may be a gene that becomes expressed at an abnormally high level; it may be a gene that becomes expressed at an abnormally low level, where the altered expression correlates with the occurrence and/or progression of the disease. A disease-associated gene also refers to a gene possessing mutation(s) or genetic variation that is directly responsible or is in linkage disequilibrium with a gene(s) that is responsible for the etiology of a disease. The transcribed or translated products may be known or unknown, and may be at a normal or abnormal level.

Embodiments of the invention also relate to methods and compositions related to knocking out genes, editing genes, altering genes, amplifying genes, and repairing particular mutations. Altering genes may also mean the epigenetic manipulation of a target sequence. This may be the chromatin state of a target sequence, such as by modification of the methylation state of the target sequence (i.e. addition or removal of methylation or methylation patterns or CpG islands), histone modification, increasing or reducing accessibility to the target sequence, or by promoting 3D folding. It will be appreciated that where reference is made to a method of modifying a cell, organism, or mammal including human or a non-human mammal or organism by manipulation of a target sequence in a genomic locus of interest, this may apply to the organism (or mammal) as a whole or just a single cell or population of cells from that organism (if the organism is multicellular). In the case of humans, for instance, Applicants envisage, inter alia, a single cell or a population of cells and these may preferably be modified ex vivo and then re-introduced. In this case, a biopsy or other tissue or biological fluid sample may be necessary. Stem cells are also particularly preferred in this regard. But, of course, in vivo embodiments are also envisaged. And the invention is especially advantageous as to HSCs.

The functionality of a targetable nuclease complex can be assessed by any suitable assay. For example, the components of a targetable nuclease system sufficient to form a targetable nuclease complex, including a guide nucleic acid and nucleic acid-guided nuclease, can be provided to a host cell having the corresponding target sequence, such as by transfection with vectors encoding the components of the engineered nuclease system, followed by an assessment of preferential cleavage within the target sequence. Similarly, cleavage of a target sequence may be evaluated in a test tube by providing the target sequence and components of a targetable nuclease complex. Other assays are possible, and will occur to those skilled in the art. A guide sequence can be selected to target any target sequence. In some embodiments, the target sequence is a sequence within a genome of a cell. Exemplary target sequences include those that are unique in the target genome.

Editing Cassette

Disclosed herein are compositions and methods for editing a target polynucleotide sequence. Such compositions include polynucleotides containing one or more components of targetable nuclease system. Polynucleotide sequences for use in these methods can be referred to as editing cassettes.

An editing cassette can comprise one or more primer sites. Primer sites can be used to amplify an editing cassette by using oligonucleotide primers comprising reverse complementary sequences that can hybridize to the one or more primer sites. An editing cassette can comprise two or more primer times. Sometimes, an editing cassette comprises a primer site on each end of the editing cassette, said primer sites flanking one or more of the other components of the editing cassette. Primer sites can be approximately 10, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 or more nucleotides in length.

An editing cassette can comprise an editing template as disclosed herein. An editing cassette can comprise an editing sequence. An editing sequence can be homologous to a target sequence. An editing sequence can comprise at least one mutation relative to a target sequence. An editing sequence often comprises homology region (or homology arms) flanking at least one mutation relative to a target sequence, such that the flanking homology regions facilitate homologous recombination of the editing sequence into a target sequence. An editing sequence can comprise an editing template as disclosed herein. For example, the editing sequence can comprise at least one mutation relative to a target sequence including one or more PAM mutations that mutate or delete a PAM site. An editing sequence can comprise one or more mutations in a codon or non-coding sequence relative to a non-editing target site.

A PAM mutation can be a silent mutation. A silent mutation can be a change to at least one nucleotide of a codon relative to the original codon that does not change the amino acid encoded by the original codon. A silent mutation can be a change to a nucleotide within a non-coding region, such as an intron, 5′ untranslated region, 3′ untranslated region, or other non-coding region.

A PAM mutation can be a non-silent mutation. Non-silent mutations can include a missense mutation. A missense mutation can be when a change to at least one nucleotide of a codon relative to the original codon that changes the amino acid encoded by the original codon. Missense mutations can occur within an exon, open reading frame, or other coding region.

An editing sequence can comprise at least one mutation relative to a target sequence. A mutation can be a silent mutation or non-silent mutation, such as a missense mutation. A mutation can include an insertion of one or more nucleotides or base pairs. A mutation can include a deletion of one or more nucleotides or base pairs. A mutation can include a substitution of one or more nucleotides or base pairs for a different one or more nucleotides or base pairs. Inserted or substituted sequences can include exogenous or heterologous sequences.

An editing cassette can comprise a polynucleotide encoding a guide nucleic acid sequence. In some cases, the guide nucleic acid sequence is optionally operably linked to a promoter. A guide nucleic acid sequence can comprise a scaffold sequence and a guide sequence as described herein.

An editing cassette can comprise a barcode. A barcode can be a unique DNA sequence that corresponds to the editing sequence such that the barcode can identify the one or more mutations of the corresponding editing sequence. In some examples, the barcode is 15 nucleotides. The barcode can comprise less than 10, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 88, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, or more than 200 nucleotides. A barcode can be a non-naturally occurring sequence. An editing cassette comprising a barcode can be a non-naturally occurring sequence.

An editing cassette can comprise one or more of an editing sequence and a polynucleotide encoding a guide nucleic acid optionally operably linked to a promoter, wherein the editing cassette and guide nucleic acid sequence are flanked by primer sites. An editing cassette can further comprise a barcode.

An example of an editing cassette is depicted in FIG. 3. Each editing cassette can be designed to edit a site in a target sequence Sites to be targeted can be coding regions, non-coding regions, functionally neutral sites, or they can be a screenable or selectable marker gene. Homology regions within the editing sequence flank the one or more mutations of the editing cassette and can be inserted into the target sequence by recombination. Recombination can comprise DNA cleavage, such as by an nucleic acid-guided nuclease, and repair via homologous recombination.

Editing cassettes can be generated by chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, overlapping oligo extension, in vitro assembly, in vitro oligo assembly, PCR, traditional ligation-based cloning, other known methods in the art, or any combination thereof.

Trackable sequences, such as barcodes or recorder sequences, can be designed in silico via standard code with a degenerate mutation at the target codon. The degenerate mutation can comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, or more than 30 nucleic acid residues. In some examples, the degenerate mutations can comprise 15 nucleic acid residues (N15).

Homology arms can be added to an editing sequence to allow incorporation of the editing sequence into the desired location via homologous recombination or homology-driven repair. Homology arms can be added by synthesis, in vitro assembly, PCR, or other known methods in the art. For example, chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, overlapping oligo extension, in vitro assembly, in vitro oligo assembly, PCR, traditional ligation-based cloning, other known methods in the art, or any combination thereof. A homology arm can be added to both ends of a barcode, recorder sequence, and/or editing sequence, thereby flanking the sequence with two distinct homology arms, for example, a 5′ homology arm and a 3′ homology arm.

A homology arm can comprise sequence homologous to a target sequence. A homology arm can comprise sequence homologous to sequence adjacent to a target sequence. A homology arm can comprise sequence homologous to sequence upstream or downstream of a target sequence. A homology arm can comprise sequence homologous to sequence within the same gene or open reading frame as a target sequence. A homology arm can comprise sequence homologous to sequence upstream or downstream of a gene or open reading frame the target sequence is within. A homology arm can comprise sequence homologous to a 5′ UTR or 3′ UTR of a gene or open reading frame within which is a target sequence. A homology arm can comprise sequence homologous to a different gene, open reading frame, promoter, terminator, or nucleic acid sequence than that which the target sequence is within.

The same 5′ and 3′ homology arms can be added to a plurality of distinct editing sequences, thereby generating a library of unique editing sequences that each have the same targeted insertion site. The same 5′ and 3′ homology arms can be added to a plurality of distinct editing templates, thereby generating a library of unique editing templates that each have the same targeted insertion site. In alternative examples, different or a variety of 5′ or 3′ homology arms can be added to a plurality of editing sequences or editing templates.

A barcode library or recorder sequence library comprising flanking homology arms can be cloned into a vector backbone. In some examples, the barcode comprising flanking homology arms are cloned into an editing cassette. Cloning can occur by chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, overlapping oligo extension, in vitro assembly, in vitro oligo assembly, PCR, traditional ligation-based cloning, other known methods in the art, or any combination thereof.

An editing sequence library comprising flanking homology arms can be cloned into a vector backbone. In some examples, the editing sequence and homology arms are cloned into an editing cassette. Editing cassettes can, in some cases, further comprise a nucleic acid sequence encoding a guide nucleic acid or gRNA engineered to target the desired site of editing sequence insertion, e.g. the target sequence. Editing cassettes can, in some cases, further comprise a barcode or recorder sequence. Cloning can occur by chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, overlapping oligo extension, in vitro assembly, in vitro oligo assembly, PCR, traditional ligation-based cloning, other known methods in the art, or any combination thereof.

Gene-wide or genome-wide editing libraries can be cloned into a vector backbone. A barcode or recorder sequence library can be inserted or assembled into a second site to generate competent trackable plasmids that can embed the recording barcode at a fixed locus while integrating the editing libraries at a wide variety of user defined sites. Cloning can occur by chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, overlapping oligo extension, in vitro assembly, in vitro oligo assembly, PCR, traditional ligation-based cloning, other known methods in the art, or any combination thereof.

A guide nucleic acid or sequence encoding the same can be assembled or inserted into a vector backbone first, followed by insertion of an editing sequence and/or cassette. In other cases, an editing sequence and/or cassette can be inserted or assembled into a vector backbone first, followed by insertion of a guide nucleic acid or sequence encoding the same. In other cases, guide nucleic acid or sequence encoding the same and an editing sequence and/or cassette are simultaneous inserted or assembled into a vector. A recorder sequence or barcode can be inserted before or after any of these steps. In other words, it should be understood that there are many possible permutations to the order in which elements of the disclosure are assembled. The vector can be linear or circular and can be generated by chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, overlapping oligo extension, in vitro assembly, in vitro oligo assembly, PCR, traditional ligation-based cloning, other known methods in the art, or any combination thereof.

A nucleic acid molecule can be synthesized which comprises one or more elements disclosed herein. A nucleic acid molecule can be synthesized that comprises an editing cassette. A nucleic acid molecule can be synthesized that comprises a guide nucleic acid. A nucleic acid molecule can be synthesized that comprises a recorder cassette. A nucleic acid molecule can be synthesized that comprises a barcode. A nucleic acid molecule can be synthesized that comprises a homology arm. A nucleic acid molecule can be synthesized that comprises an editing cassette and a guide nucleic acid. A nucleic acid molecule can be synthesized that comprises an editing cassette and a barcode. A nucleic acid molecule can be synthesized that comprises an editing cassette, a guide nucleic acid, and a recorder cassette. A nucleic acid molecule can be synthesized that comprises an editing cassette, a recorder cassette, and two guide nucleic acids. A nucleic acid molecule can be synthesized that comprises a recorder cassette and a guide nucleic acid. In any of these cases, the guide nucleic acid can optionally be operably linked to a promoter. In any of these cases, the nucleic acid molecule can further include one or more barcodes.

Synthesis can occur by any nucleic acid synthesis method known in the art. Synthesis can occur by enzymatic nucleic acid synthesis. Synthesis can occur by chemical synthesis. Synthesis can occur by array-based synthesis. Synthesis can occur by solid-phase synthesis or phosphoramidite methods. Synthesis can occur by column or multi-well methods. Synthesized nucleic acid molecules can be non-naturally occurring nucleic acid molecules.

Software and automation methods can be used for multiplex synthesis and generation. For example, software and automation can be used to create 10, 10², 10³, 10⁴, 10⁵, 10⁶, or more synthesized polynucleotides, cassettes, or plasmids. An automation method can generate desired sequences and libraries in rapid fashion that can be processed through a workflow with minimal steps to produce precisely defined libraries, such as gene-wide or genome-wide editing libraries.

Polynucleotides or libraries can be generated which comprise two or more nucleic acid molecules or plasmids comprising any combination disclosed herein of recorder sequence, editing sequence, guide nucleic acid, and optional barcode, including combinations of one or more of any of the previously mentioned elements. For example, such a library can comprise at least 2, 3, 4, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, 600, 700, 800, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500, 7000, 7500, 8000, 8500, 9000, 9500, 10⁴, 10⁵, 10⁶, 10⁷, 108, 10⁹, 10¹⁰, or more nucleic acid molecules or plasmids of the present disclosure. It should be understood that such a library can include any number of nucleic acid molecules or plasmids, even if the specific number is not explicit listed above.

Trackable plasmid libraries or nucleic acid molecule libraries can be sequenced in order to determine the recorder sequence and editing sequence pair that is comprised on each trackable plasmid. In other cases, a known recorder sequence is paired with a known editing sequence during the library generation process. Other methods of determining the association between a recorder sequence and editing sequence comprised on a common nucleic acid molecule or plasmid are envisioned such that the editing sequence can be identified by identification or sequencing of the recorder sequence.

Methods and compositions for tracking edited episomal libraries that are shuttled between E. coli and other organisms/cell lines are provided herein. The libraries can be comprised on plasmids, Bacterial artificial chromosomes (BACs), Yeast artificial chromosomes (YACs), synthetic chromosomes, or viral or phage genomes. These methods and compositions can be used to generate portable barcoded libraries in host organisms, such as E. coli. Library generation in such organisms can offer the advantage of established techniques for performing homologous recombination. Barcoded plasmid libraries can be deep-sequenced at one site to track mutational diversity targeted across the remaining portions of the plasmid allowing dramatic improvements in the depth of library coverage.

Any nucleic acid molecule disclosed herein can be an isolated nucleic acid. Isolated nucleic acids may be made by any method known in the art, for example using standard recombinant methods, assembly methods, synthesis techniques, or combinations thereof. In some embodiments, the nucleic acids may be cloned, amplified, assembled, or otherwise constructed.

Isolated nucleic acids may be obtained from cellular, bacterial, or other sources using any number of cloning methodologies known in the art. In some embodiments, oligonucleotide probes which selectively hybridize, under stringent conditions, to other oligonucleotides or to the nucleic acids of an organism or cell can be used to isolate or identify an isolated nucleic acid.

Cellular genomic DNA, RNA, or cDNA may be screened for the presence of an identified genetic element of interest using a probe based upon one or more sequences. Various degrees of stringency of hybridization may be employed in the assay.

High stringency conditions for nucleic acid hybridization are well known in the art. For example, conditions may comprise low salt and/or high temperature conditions, such as provided by about 0.02 M to about 0.15 M NaCl at temperatures of about 500° C. to about 70° C. It is understood that the temperature and ionic strength of a desired stringency are determined in part by the length of the particular nucleic acid(s), the length and nucleotide content of the target sequence(s), the charge composition of the nucleic acid(s), and by the presence or concentration of formamide, tetramethylammonium chloride or other solvent(s) in a hybridization mixture. Nucleic acids may be completely complementary to a target sequence or may exhibit one or more mismatches.

Nucleic acids of interest may also be amplified using a variety of known amplification techniques. For instance, polymerase chain reaction (PCR) technology may be used to amplify target sequences directly from DNA, RNA, or cDNA. PCR and other in vitro amplification methods may also be useful, for example, to clone nucleic acid sequences, to make nucleic acids to use as probes for detecting the presence of a target nucleic acid in samples, for nucleic acid sequencing, or for other purposes.

Isolated nucleic acids may be prepared by direct chemical synthesis by methods such as the phosphotriester method, or using an automated synthesizer. Chemical synthesis generally produces a single stranded oligonucleotide. This may be converted into double stranded DNA by hybridization with a complementary sequence or by polymerization with a DNA polymerase using the single strand as a template.

Recorder

In some example, two editing cassettes can be used together to track a genetic engineering step. For example, one editing cassette can comprise an editing template and an encoded guide nucleic acid, and a second editing cassette, referred to as a recorder cassette, can comprise an editing template comprising a recorder sequence and an encoded nucleic acid which has a distinct guide sequence compared to that of the first editing cassette. In such cases, the editing sequence and the recorder sequence can be inserted into separate target sequences and determined by their corresponding guide nucleic acids. A recorder sequence can comprise a barcode, trackable or traceable sequence, and/or a regulatory element operable with a screenable or selectable marker.

Through a multiplexed cloning approach, the recorder cassette can be covalently coupled to at least one editing cassette in a plasmid (e.g., FIG. 17A, green cassette) to generate plasmid libraries that have a unique recorder and editing cassette combination. This library can be sequenced to generate the recorder/edit mapping and used to track editing libraries across large segments of the target DNA (e.g., FIG. 17C). Recorder and editing sequences can be comprised on the same cassette, in which case they are both incorporated into the target nucleic acid sequence, such as a genome or plasmid, by the same recombination event. In other examples, the recorder and editing sequences can be comprised on separate cassettes within the same plasmid, in which case the recorder and editing sequences are incorporated into the target nucleic acid sequence by separate recombination events, either simultaneously or sequentially.

Methods are provided herein for combining multiplex oligonucleotide synthesis with recombineering, to create libraries of specifically designed and trackable mutations. Screens and/or selections followed by high-throughput sequencing and/or barcode microarray methods can allow for rapid mapping of mutations leading to a phenotype of interest.

Methods and compositions disclosed herein can be used to simultaneously engineer and track engineering events in a target nucleic acid sequence.

Such plasmids can be generated using in vitro assembly or cloning techniques. For example, the plasmids can be generated using chemical synthesis, Gibson assembly, SLIC, CPEC, PCA, ligation-free cloning, other in vitro oligo assembly techniques, traditional ligation-based cloning, or any combination thereof.

Such plasmids can comprise at least one recording sequence, such as a barcode, and at least one editing sequence. In most cases, the recording sequence is used to record and track engineering events. Each editing sequence can be used to incorporate a desired edit into a target nucleic acid sequence. The desired edit can include insertion, deletion, substitution, or alteration of the target nucleic acid sequence. In some examples, the one or more recording sequence and editing sequences are comprised on a single cassette comprised within the plasmid such that they are incorporated into the target nucleic acid sequence by the same engineering event. In other examples, the recording and editing sequences are comprised on separate cassettes within the plasmid such that they are each incorporated into the target nucleic acid by distinct engineering events. In some examples, the plasmid comprises two or more editing sequences. For example, one editing sequence can be used to alter or silence a PAM sequence while a second editing sequence can be used to incorporate a mutation into a distinct sequence.

Recorder sequences can be inserted into a site separated from the editing sequence insertion site. The inserted recorder sequence can be separated from the editing sequence by 1 bp to 1 Mbp. For example, the separation distance can be about 1 bp, 10 bp, 50 bp, 100 bp, 500 bp, 1 kp, 2 kb, 5 kb, 10 kb, or greater. The separation distance can be any discrete integer between 1 bp and 10 Mbp. In some examples, the maximum distance of separation depends on the size of the target nucleic acid or genome.

Recorder sequences can be inserted adjacent to editing sequences, or within proximity to the editing sequence. For example, the recorder sequence can be inserted outside of the open reading frame within which the editing sequence is inserted. Recorder sequence can be inserted into an untranslated region adjacent to an open reading frame within which an editing sequence has been inserted. The recorder sequence can be inserted into a functionally neutral or non-functional site. The recorder sequence can be inserted into a screenable or selectable marker gene.

In some examples, the target nucleic acid sequence is comprised within a genome, artificial chromosome, synthetic chromosome, or episomal plasmid. In various examples, the target nucleic acid sequence can be in vitro or in vivo. When the target nucleic acid sequence is in vivo, the plasmid can be introduced into the host organisms by transformation, transfection, conjugation, biolistics, nanoparticles, cell-permeable technologies, or other known methods for DNA delivery, or any combination thereof. In such examples, the host organism can be a eukaryote, prokaryote, bacterium, archaea, yeast, or other fungi.

The engineering event can comprise recombineering, non-homologous end joining, homologous recombination, or homology-driven repair. In some examples, the engineering event is performed in vitro or in vivo.

The methods described herein can be carried out in any type of cell in which a targetable nuclease system can function (e.g., target and cleave DNA), including prokaryotic and eukaryotic cells. In some embodiments the cell is a bacterial cell, such as Escherichia spp. (e.g., E. coli). In other embodiments, the cell is a fungal cell, such as a yeast cell, e.g., Saccharomyces spp. In other embodiments, the cell is an algal cell, a plant cell, an insect cell, or a mammalian cell, including a human cell.

In some examples, the cell is a recombinant organism. For example, the cell can comprise a non-native targetable nuclease system. Additionally or alternatively, the cell can comprise recombination system machinery. Such recombination systems can include lambda red recombination system, Cre/Lox, attB/attP, or other integrase systems. Where appropriate, the plasmid can have the complementary components or machinery required for the selected recombination system to work correctly and efficiently.

Method for genome editing can comprise: (a) introducing a vector that encodes at least one editing cassette and at least one guide nucleic acid into a first population of cells, thereby producing a second population of cells comprising the vector; (b) maintaining the second population of cells under conditions in which a nucleic acid-guided nuclease is expressed or maintained, wherein the nucleic acid-guided nuclease is encoded on the vector, a second vector, on the genome of cells of the second population of cells, or otherwise introduced into the cell, resulting in DNA cleavage and incorporation of the editing cassette; (c) obtaining viable cells; and (d) sequencing the target DNA molecule in at least one cell of the second population of cells to identify the mutation of at least one codon.

A method for genome editing can comprise: (a) introducing a vector that encodes at least one editing cassette comprising a PAM mutation as disclosed herein and at least one guide nucleic acid into a first population of cells, thereby producing a second population of cells comprising the vector; (b) maintaining the second population of cells under conditions in which a nucleic acid-guided nuclease is expressed or maintained, wherein the nucleic acid-guided nuclease is encoded on the vector, a second vector, on the genome of cells of the second population of cells, or otherwise introduced into the cell, resulting in DNA cleavage, incorporation of the editing cassette, and death of cells of the second population of cells that do not comprise the PAM mutation, whereas cells of the second population of cells that comprise the PAM mutation are viable; (c) obtaining viable cells; and (d) sequencing the target DNA in at least one cell of the second population of cells to identify the mutation of at least one codon.

Method for trackable genome editing can comprise: (a) introducing a vector that encodes at least one editing cassette, at least one recorder cassette, and at least two guide nucleic acids into a first population of cells, thereby producing a second population of cells comprising the vector; (b) maintaining the second population of cells under conditions in which a nucleic acid-guided nuclease is expressed or maintained, wherein the nucleic acid-guided nuclease is encoded on the vector, a second vector, on the genome of cells of the second population of cells, or otherwise introduced into the cell, resulting in DNA cleavage and incorporation of the editing and recorder cassettes; (c) obtaining viable cells; and (d) sequencing the recorder sequence of the target DNA molecule in at least one cell of the second population of cells to identify the mutation of at least one codon.

In some examples where the plasmid comprises a second editing sequence designed to silence a PAM, a method for trackable genome editing can comprise: (a) introducing a vector that encodes at least one editing cassette, a recorder cassette, and at least two guide nucleic acids into a first population of cells, thereby producing a second population of cells comprising the vector; (b) maintaining the second population of cells under conditions in which a nucleic acid-guided nuclease is expressed or maintained, wherein the nucleic acid-guided nuclease is encoded on the vector, a second vector, on the genome of cells of the second population of cells, or otherwise introduced into the cell, resulting in DNA cleavage, incorporation of the editing and recorder cassettes, and death of cells of the second population of cells that do not comprise the PAM mutation, whereas cells of the second population of cells that comprise the PAM mutation are viable; (c) obtaining viable cells; and (d) sequencing the recorder sequence of the target DNA in at least one cell of the second population of cells to identify the mutation of at least one codon.

In some examples transformation efficiency is determined by using a non-targeting control guide nucleic acid, which allows for validation of the recombineering procedure and CFU/ng calculations. In some cases, absolute efficient is obtained by counting the total number of colonies on each transformation plate, for example, by counting both red and white colonies from a galK control. In some examples, relative efficiency is calculated by the total number of successful transformants (for example, white colonies) out of all colonies from a control (for example, galK control).

The methods of the disclosure can provide, for example, greater than 1000× improvements in the efficiency, scale, cost of generating a combinatorial library, and/or precision of such library generation.

The methods of the disclosure can provide, for example, greater than: 10×, 50×, 100×, 200×, 300×, 400×, 500×, 600×, 700×, 800×, 900×, 1000×, 1100×, 1200×, 1300×, 1400×, 1500×, 1600×, 1700×, 1800×, 1900×, 2000×, or greater improvements in the efficiency of generating genomic or combinatorial libraries.

The methods of the disclosure can provide, for example, greater than: 10×, 50×, 100×, 200×, 300×, 400×, 500×, 600×, 700×, 800×, 900×, 1000×, 1100×, 1200×, 1300×, 1400×, 1500×, 1600×, 1700×, 1800×, 1900×, 2000×, or greater improvements in the scale of generating genomic or combinatorial libraries.

The methods of the disclosure can provide, for example, greater than: 10×, 50×, 100×, 200×, 300×, 400×, 500×, 600×, 700×, 800×, 900×, 1000×, 1100×, 1200×, 1300×, 1400×, 1500×, 1600×, 1700×, 1800×, 1900×, 2000×, or greater decrease in the cost of generating genomic or combinatorial libraries.

The methods of the disclosure can provide, for example, greater than: 10×, 50×, 100×, 200×, 300×, 400×, 500×, 600×, 700×, 800×, 900×, 1000×, 1100×, 1200×, 1300×, 1400×, 1500×, 1600×, 1700×, 1800×, 1900×, 2000×, or greater improvements in the precision of genomic or combinatorial library generation.

Recursive Tracking for Combinatorial Engineering

Disclosed herein are methods and compositions for iterative rounds of engineering. Disclosed herein are recursive engineering strategies that allow implementation of CREATE recording at the single cell level through several serial engineering cycles (e.g., FIG. 18 and FIG. 19). These disclosed methods and compositions can enable search-based technologies that can effectively construct and explore complex genotypic space. The terms recursive and iterative can be used interchangeably.

Combinatorial engineering methods can comprise multiple rounds of engineering. Methods disclosed herein can comprise 2 or more rounds of engineering. For example, a method can comprise 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, or more than 30 rounds of engineering.

In some examples, during each round of engineering a new recorder sequence, such as a barcode, is incorporated at the same locus in nearby sites (e.g., FIG. 18, green bars or FIG. 19, black bars) such that following multiple engineering cycles to construct combinatorial diversity throughout the genome (e.g., FIG. 18, green bars or FIG. 19, grey bars) a simple PCR of the recording locus can be used to reconstruct each combinatorial genotype or to confirm that the engineered edit from each round has been incorporated into the target site.

Disclosed herein are methods for selecting for successive rounds of engineering. Selection can occur by a PAM mutation incorporated by an editing cassette. Selection can occur by a PAM mutation incorporated by a recorder cassette. Selection can occur using a screenable, selectable, or counter-selectable marker. Selection can occur by targeting a site for editing or recording that was incorporated by a prior round of engineering, thereby selecting for variants that successfully incorporated edits and recorder sequences from both rounds or all prior rounds of engineering.

Quantitation of these genotypes can be used for understanding combinatorial mutational effects on large populations and investigation of important biological phenomena such as epistasis.

Serial editing and combinatorial tracking can be implemented using recursive vector systems as disclosed herein. These recursive vector systems can be used to move rapidly through the transformation procedure. In some examples, these systems consist of two or more plasmids containing orthogonal replication origins, antibiotic markers, and an encoded guide nucleic acids. The encoded guide nucleic acid in each vector can be designed to target one of the other resistance markers for destruction by nucleic acid-guided nuclease-mediated cleavage. These systems can be used, in some examples, to perform transformations in which the antibiotic selection pressure is switched to remove the previous plasmid and drive enrichment of the next round of engineered genomes. Two or more passages through the transformation loop can be performed, or in other words, multiple rounds of engineering can be performed. Introducing the requisite recording cassettes and editing cassettes into recursive vectors as disclosed herein can be used for simultaneous genome editing and plasmid curing in each transformation step with high efficiencies.

In some examples, the recursive vector system disclosed herein comprises 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 unique plasmids. In some examples, the recursive vector system can use a particular plasmid more than once as long as a distinct plasmid is used in the previous round and in the subsequent round.

Recursive methods and compositions disclosed herein can be used to restore function to a selectable or screenable element in a targeted genome or plasmid. The selectable or screenable element can include an antibiotic resistance gene, a fluorescent gene, a unique DNA sequence or watermark, or other known reporter, screenable, or selectable gene. In some examples, each successive round of engineering can incorporate a fragment of the selectable or screenable element, such that at the end of the engineering rounds, the entire selectable or screenable element has been incorporated into the target genome or plasmid. In such examples, only those genome or plasmids which have successfully incorporated all of the fragments, and therefore all of the desired corresponding mutations, can be selected or screened for. In this way, the selected or screened cells will be enriched for those that have incorporated the edits from each and every iterative round of engineering.

Recursive methods can be used to switch a selectable or screenable marker between an on and an off position, or between an off and an on position, with each successive round of engineering. Using such a method allows conservation of available selectable or screenable markers by requiring, for example, the use of only one screenable or selectable marker. Furthermore, short regulatory sequence or start codon or non-start codons can be used to turn the screenable or selectable marker on and off. Such short sequences can easily fit within a synthesized cassette or polynucleotide.

One or more rounds of engineering can be performed using the methods and compositions disclosed herein. In some examples, each round of engineering is used to incorporate an edit unique from that of previous rounds. Each round of engineering can incorporate a unique recording sequence. Each round of engineering can result in removal or curing of the plasmid used in the previous round of engineering. In some examples, successful incorporation of the recording sequence of each round of engineering results in a complete and functional screenable or selectable marker or unique sequence combination.

Unique recorder cassettes comprising recording sequences such as barcodes or screenable or selectable markers can be inserted with each round of engineering, thereby generating a recorder sequence that is indicative of the combination of edits or engineering steps performed. Successive recording sequences can be inserted adjacent to one another. Successive recording sequences can be inserted within proximity to one another. Successive sequences can be inserted at a distance from one another.

Successive sequences can be inserted at a distance from one another. For example, successive recorder sequences can be inserted and separated by 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, or greater than 100 bp. In some examples, successive recorder sequences are separated by about 10, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1100, 1200, 1300, 1400, 1500, or greater than 1500 bp.

Successive recorder sequences can be separated by any desired number of base pairs and can be dependent and limited on the number of successive recorder sequences to be inserted, the size of the target nucleic acid or target genomes, and/or the design of the desired final recorder sequence. For example, if the compiled recorder sequence is a functional screenable or selectable marker, than the successive recording sequences can be inserted within proximity and within the same reading frame from one another. If the compiled recorder sequence is a unique set of barcodes to be identified by sequencing and have no coding sequence element, then the successive recorder sequences can be inserted with any desired number of base pairs separating them. In these cases, the separation distance can be dependent on the sequencing technology to be used and the read length limit.

While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby.

Some Definitions

As used herein the term “wild type” is a term of the art understood by skilled persons and means the typical form of an organism, strain, gene or characteristic as it occurs in nature as distinguished from mutant or variant forms.

As used herein the term “variant” should be taken to mean the exhibition of qualities that have a pattern that deviates from what occurs in nature.

The terms “orthologue” (also referred to as “ortholog” herein) and “homologue” (also referred to as “homolog” herein) are well known in the art. By means of further guidance, a “homologue” of a protein as used herein is a protein of the same species which performs the same or a similar function as the protein it is a homologue of. Homologous proteins may but need not be structurally related, or are only partially structurally related. An “orthologue” of a protein as used herein is a protein of a different species which performs the same or a similar function as the protein it is an orthologue of Orthologous proteins may but need not be structurally related, or are only partially structurally related. Homologs and orthologs may be identified by homology modelling (see, e.g., Greer, Science vol. 228 (1985) 1055, and Blundell et al. Eur J Biochem vol 172 (1988), 513) or “structural BLAST” (Dey F, Cliff Zhang Q, Petrey D, Honig B. Toward a “structural BLAST”: using structural relationships to infer function. Protein Sci. 2013 April; 22(4):359-66. doi: 10.1002/pro.2225.).

The terms “polynucleotide”, “nucleotide”, “nucleotide sequence”, “nucleic acid” and “oligonucleotide” are used interchangeably. They refer to a polymeric form of nucleotides of any length, either deoxyribonucleotides or ribonucleotides, or analogs thereof. Polynucleotides may have any three dimensional structure, and may perform any function, known or unknown. The following are non-limiting examples of polynucleotides: coding or non-coding regions of a gene or gene fragment, loci (locus) defined from linkage analysis, exons, introns, messenger RNA (mRNA), transfer RNA, ribosomal RNA, short interfering RNA (siRNA), short-hairpin RNA (shRNA), micro-RNA (miRNA), ribozymes, cDNA, recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, nucleic acid probes, and primers. The term also encompasses nucleic-acid-like structures with synthetic backbones, see, e.g., Eckstein, 1991; Baserga et al., 1992; Milligan, 1993; WO 97/03211; WO 96/39154; Mata, 1997; Strauss-Soukup, 1997; and Samstag, 1996. A polynucleotide may comprise one or more modified nucleotides, such as methylated nucleotides and nucleotide analogs. If present, modifications to the nucleotide structure may be imparted before or after assembly of the polymer. The sequence of nucleotides may be interrupted by non-nucleotide components. A polynucleotide may be further modified after polymerization, such as by conjugation with a labeling component.

“Complementarity” refers to the ability of a nucleic acid to form hydrogen bond(s) with another nucleic acid sequence by either traditional Watson-Crick base pairing or other non-traditional types. A percent complementarity indicates the percentage of residues in a nucleic acid molecule which can form hydrogen bonds (e.g., Watson-Crick base pairing) with a second nucleic acid sequence (e.g., 5, 6, 7, 8, 9, 10 out of 10 being 50%, 60%, 70%, 80%, 90%, and 100% complementary). “Perfectly complementary” means that all the contiguous residues of a nucleic acid sequence will hydrogen bond with the same number of contiguous residues in a second nucleic acid sequence. “Substantially complementary” as used herein refers to a degree of complementarity that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% over a region of 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, or more nucleotides, or refers to two nucleic acids that hybridize under stringent conditions.

As used herein, “stringent conditions” for hybridization refer to conditions under which a nucleic acid having complementarity to a target sequence predominantly hybridizes with the target sequence, and substantially does not hybridize to non-target sequences. Stringent conditions are generally sequence-dependent, and vary depending on a number of factors. In general, the longer the sequence, the higher the temperature at which the sequence specifically hybridizes to its target sequence. Non-limiting examples of stringent conditions are described in detail in Tijssen (1993). Laboratory Techniques In Biochemistry And Molecular Biology-Hybridization With Nucleic Acid Probes Part I, Second Chapter “Overview of principles of hybridization and the strategy of nucleic acid probe assay”, Elsevier, N.Y. Where reference is made to a polynucleotide sequence, then complementary or partially complementary sequences are also envisaged. These are preferably capable of hybridising to the reference sequence under highly stringent conditions. Generally, in order to maximize the hybridization rate, relatively low-stringency hybridization conditions are selected: about 20 to 25 degrees Celsius. lower than the thermal melting point (Tm). The Tm is the temperature at which 50% of specific target sequence hybridizes to a perfectly complementary probe in solution at a defined ionic strength and pH. Generally, in order to require at least about 85% nucleotide complementarity of hybridized sequences, highly stringent washing conditions are selected to be about 5 to 15 degrees Celsius lower than the Tm. In order to require at least about 70% nucleotide complementarity of hybridized sequences, moderately-stringent washing conditions are selected to be about 15 to 30 degrees Celsius lower than the Tm. Highly permissive (very low stringency) washing conditions may be as low as 50 degrees Celsius below the Tm, allowing a high level of mis-matching between hybridized sequences. Those skilled in the art will recognize that other physical and chemical parameters in the hybridization and wash stages can also be altered to affect the outcome of a detectable hybridization signal from a specific level of homology between target and probe sequences.

“Hybridization” refers to a reaction in which one or more polynucleotides react to form a complex that is stabilized via hydrogen bonding between the bases of the nucleotide residues. The hydrogen bonding may occur by Watson Crick base pairing, Hoogstein binding, or in any other sequence specific manner. The complex may comprise two strands forming a duplex structure, three or more strands forming a multi stranded complex, a single self-hybridizing strand, or any combination of these. A hybridization reaction may constitute a step in a more extensive process, such as the initiation of PCR, or the cleavage of a polynucleotide by an enzyme. A sequence capable of hybridizing with a given sequence is referred to as the “complement” of the given sequence.

As used herein, the term “genomic locus” or “locus” (plural loci) is the specific location of a gene or DNA sequence on a chromosome. A “gene” refers to stretches of DNA or RNA that encode a polypeptide or an RNA chain that has functional role to play in an organism and hence is the molecular unit of heredity in living organisms. For the purpose of this invention it may be considered that genes include regions which regulate the production of the gene product, whether or not such regulatory sequences are adjacent to coding and/or transcribed sequences. Accordingly, a gene includes, but is not necessarily limited to, promoter sequences, terminators, translational regulatory sequences such as ribosome binding sites and internal ribosome entry sites, enhancers, silencers, insulators, boundary elements, replication origins, matrix attachment sites and locus control regions.

As used herein, “expression of a genomic locus” or “gene expression” is the process by which information from a gene is used in the synthesis of a functional gene product. The products of gene expression are often proteins, but in non-protein coding genes such as rRNA genes or tRNA genes, the product is functional RNA. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea) and viruses to generate functional products to survive. As used herein “expression” of a gene or nucleic acid encompasses not only cellular gene expression, but also the transcription and translation of nucleic acid(s) in cloning systems and in any other context. As used herein, “expression” also refers to the process by which a polynucleotide is transcribed from a DNA template (such as into and mRNA or other RNA transcript) and/or the process by which a transcribed mRNA is subsequently translated into peptides, polypeptides, or proteins. Transcripts and encoded polypeptides may be collectively referred to as “gene product.” If the polynucleotide is derived from genomic DNA, expression may include splicing of the mRNA in a eukaryotic cell.

The terms “polypeptide”, “peptide” and “protein” are used interchangeably herein to refer to polymers of amino acids of any length. The polymer may be linear or branched, it may comprise modified amino acids, and it may be interrupted by non amino acids. The terms also encompass an amino acid polymer that has been modified; for example, disulfide bond formation, glycosylation, lipidation, acetylation, phosphorylation, or any other manipulation, such as conjugation with a labeling component. As used herein the term “amino acid” includes natural and/or unnatural or synthetic amino acids, including glycine and both the D or L optical isomers, and amino acid analogs and peptidomimetics.

As used herein, the term “domain” or “protein domain” refers to a part of a protein sequence that may exist and function independently of the rest of the protein chain.

As described in aspects of the invention, sequence identity is related to sequence homology. Homology comparisons may be conducted by eye, or more usually, with the aid of readily available sequence comparison programs. These commercially available computer programs may calculate percent (%) homology between two or more sequences and may also calculate the sequence identity shared by two or more amino acid or nucleic acid sequences. Sequence homologies may be generated by any of a number of computer programs known in the art, for example BLAST or FASTA, etc. A suitable computer program for carrying out such an alignment is the GCG Wisconsin Bestfit package (University of Wisconsin. U.S.A; Devereux et al., 1984, Nucleic Acids Research 12:387). Examples of other software than may perform sequence comparisons include, but are not limited to, the BLAST package (see Ausubel et al., 1999 ibid—Chapter 18), FASTA (Atschul et al., 1990, J. Mol. Biol., 403-410) and the GENEWORKS suite of comparison tools. Both BLAST and FASTA are available for offline and online searching (see Ausubel et al., 1999 ibid, pages 7-58 to 7-60). However it is preferred to use the GCG Bestfit program.

Percent homology may be calculated over contiguous sequences, i.e., one sequence is aligned with the other sequence and each amino acid or nucleotide in one sequence is directly compared with the corresponding amino acid or nucleotide in the other sequence, one residue at a time. This is called an “ungapped” alignment. Typically, such ungapped alignments are performed only over a relatively short number of residues.

Although this is a very simple and consistent method, it fails to take into consideration that, for example, in an otherwise identical pair of sequences, one insertion or deletion may cause the following amino acid residues to be put out of alignment, thus potentially resulting in a large reduction in % homology when a global alignment is performed. Consequently, most sequence comparison methods are designed to produce optimal alignments that take into consideration possible insertions and deletions without unduly penalizing the overall homology or identity score. This is achieved by inserting “gaps” in the sequence alignment to try to maximize local homology or identity.

However, these more complex methods assign “gap penalties” to each gap that occurs in the alignment so that, for the same number of identical amino acids, a sequence alignment with as few gaps as possible—reflecting higher relatedness between the two compared sequences—may achieve a higher score than one with many gaps. “Affinity gap costs” are typically used that charge a relatively high cost for the existence of a gap and a smaller penalty for each subsequent residue in the gap. This is the most commonly used gap scoring system. High gap penalties may, of course, produce optimized alignments with fewer gaps. Most alignment programs allow the gap penalties to be modified. However, it is preferred to use the default values when using such software for sequence comparisons. For example, when using the GCG Wisconsin Bestfit package the default gap penalty for amino acid sequences is −12 for a gap and −4 for each extension.

Calculation of maximum % homology therefore first requires the production of an optimal alignment, taking into consideration gap penalties. A suitable computer program for carrying out such an alignment is the GCG Wisconsin Bestfit package (Devereux et al., 1984 Nuc. Acids Research 12 p387). Examples of other software that may perform sequence comparisons include, but are not limited to, the BLAST package (see Ausubel et al., 1999 Short Protocols in Molecular Biology, 4th Ed.—Chapter 18), FASTA (Altschul et al., 1990 J. Mol. Biol. 403-410) and the GENEWORKS suite of comparison tools. Both BLAST and FASTA are available for offline and online searching (see Ausubel et al., 1999, Short Protocols in Molecular Biology, pages 7-58 to 7-60). However, for some applications, it is preferred to use the GCG Bestfit program. A new tool, called BLAST 2 Sequences is also available for comparing protein and nucleotide sequences (see FEMS Microbiol Lett. 1999 174(2): 247-50; FEMS Microbiol Lett. 1999 177(1): 187-8 and the website of the National Center for Biotechnology information at the website of the National Institutes for Health).

Although the final % homology may be measured in terms of identity, the alignment process itself is typically not based on an all-or-nothing pair comparison. Instead, a scaled similarity score matrix is generally used that assigns scores to each pair-wise comparison based on chemical similarity or evolutionary distance. An example of such a matrix commonly used is the BLOSUM62 matrix—the default matrix for the BLAST suite of programs. GCG Wisconsin programs generally use either the public default values or a custom symbol comparison table, if supplied (see user manual for further details). For some applications, it is preferred to use the public default values for the GCG package, or in the case of other software, the default matrix, such as BLOSUM62.

Alternatively, percentage homologies may be calculated using the multiple alignment feature in DNASIS™ (Hitachi Software), based on an algorithm, analogous to CLUSTAL (Higgins D G & Sharp P M (1988), Gene 73(1), 237-244). Once the software has produced an optimal alignment, it is possible to calculate % homology, preferably % sequence identity. The software typically does this as part of the sequence comparison and generates a numerical result.

Sequences may also have deletions, insertions or substitutions of amino acid residues which produce a silent change and result in a functionally equivalent substance. Deliberate amino acid substitutions may be made on the basis of similarity in amino acid properties (such as polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues) and it is therefore useful to group amino acids together in functional groups. Amino acids may be grouped together based on the properties of their side chains alone. However, it is more useful to include mutation data as well. The sets of amino acids thus derived are likely to be conserved for structural reasons. These sets may be described in the form of a Venn diagram (Livingstone C. D. and Barton G. J. (1993) “Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation” Comput. Appl. Biosci. 9: 745-756) (Taylor W. R. (1986) “The classification of amino acid conservation” J. Theor. Biol. 119; 205-218). Conservative substitutions may be made, for example according to the table below which describes a generally accepted Venn diagram grouping of amino acids.

Embodiments of the invention include sequences (both polynucleotide or polypeptide) which may comprise homologous substitution (substitution and replacement are both used herein to mean the interchange of an existing amino acid residue or nucleotide, with an alternative residue or nucleotide) that may occur i.e., like-for-like substitution in the case of amino acids such as basic for basic, acidic for acidic, polar for polar, etc. Non-homologous substitution may also occur i.e., from one class of residue to another or alternatively involving the inclusion of unnatural amino acids such as ornithine (hereinafter referred to as Z), diaminobutyric acid ornithine (hereinafter referred to as B), norleucine ornithine (hereinafter referred to as O), pyridylalanine, thienylalanine, naphthylalanine and phenylglycine.

Variant amino acid sequences may include suitable spacer groups that may be inserted between any two amino acid residues of the sequence including alkyl groups such as methyl, ethyl or propyl groups in addition to amino acid spacers such as glycine or .beta.-alanine residues. A further form of variation, which involves the presence of one or more amino acid residues in peptoid form, may be well understood by those skilled in the art. For the avoidance of doubt, “the peptoid form” is used to refer to variant amino acid residues wherein the .alpha.-carbon substituent group is on the residue's nitrogen atom rather than the .alpha.-carbon. Processes for preparing peptides in the peptoid form are known in the art, for example Simon R J et al., PNAS (1992) 89(20), 9367-9371 and Horwell D C, Trends Biotechnol. (1995) 13(4), 132-134.

The practice of the present invention employs, unless otherwise indicated, conventional techniques of immunology, biochemistry, chemistry, molecular biology, microbiology, cell biology, genomics and recombinant DNA, which are within the skill of the art. See Green and Sambrook, (Molecular Cloning: A Laboratory Manual. 4th, ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 2014); CURRENT PROTOCOLS IN MOLECULAR BIOLOGY (F. M. Ausubel, et al. eds., (2017)); Short Protocols in Molecular Biology, (Ausubel et al., 1999)); the series METHODS IN ENZYMOLOGY (Academic Press, Inc.): PCR 2: A PRACTICAL APPROACH (M. J. MacPherson, B. D. Hames and G. R. Taylor eds. (1995)), ANTIBODIES, A LABORATORY MANUAL, SECOND EDITION (Harlow and Lane, eds. (2014) and CULTURE OF ANIMAL CELLS: A MANUAL BASIC TECHNIQUE, 7TH EDITION (R. I. Freshney, ed. (2016)).

EXAMPLES

The following examples are given for the purpose of illustrating various embodiments of the invention and are not meant to limit the present invention in any fashion. The present examples, along with the methods described herein are presently representative of preferred embodiments, are exemplary, and are not intended as limitations on the scope of the invention. Changes therein and other uses which are encompassed within the spirit of the invention as defined by the scope of the claims will occur to those skilled in the art.

Example 1. Nucleic Acid-Guided Nucleases

Sequences for twenty nucleic acid guided nucleases, termed MAD1-MAD20 (SEQ ID NOs 1-20), were aligned and compared to other nucleic acid guided nucleases. A partial alignment and phylogenetic tree are depicted in FIG. 1A and FIG. 1B respectively. Key residues in that may be involved in the recognition of a PAM site are shown in FIG. 1A. These include amino acids at positions 167, 539, 548, 599, 603, 604, 605, 606, and 607.

Sequence alignments were built using PSI-BLAST to search for MAD nuclease homologs in the NCBI non-redundant databases. Multiple sequence alignments were further refined using the MUSCLE alignment algorithm with default settings as implemented in Geneious 10. The percent identity of each homolog to SpCas9 and AsCpf 1 reference sequences were computed based on the pairwise alignment matching from these global alignments.

Genomic source sequences were identified using Uniprot linkage information or TBLASTN searches of NCBI using the default parameters and searching all possible frames for translational matches.

Percent identities of MAD1-8 and 10-12 to other various nuclease are summarized in Table 1. These percent identities represent the shared amino acid sequence identity between the indicated proteins.

TABLE 1

Protein identifier or accession number
MAD1
MAD2
MAD3
MAD4
MAD5
MAD6
MAD7
MAD8
MAD10
MAD11
MAD12

gi|1025734861|pdb|5B43|A
6.4
32.8
33.2
29.7
29.4
31.1
30.3
31.7
26.7
27.9
98.8

gi|1052245173|pdb|5KK5|A
6.4
32.7
33.1
29.7
29.3
31
30.3
31.7
26.7
27.8
98.7

gi|1086216683|emb|SDC16215.1|
6.1
33
34.4
29.6
30.1
33.5
32.3
32.1
26.2
27.2
46.8

gi|1120175333|ref|WP_073043853.1|
5.9
30.9
37.2
32.8
33.6
34.4
35.7
35.1
26.3
28.3
34.9

Cpf1.Sj|WP_081839471
6.6
33.6
41.7
37.2
33.4
37.6
40.1
37.7
29.1
30.3
34.1

Cpf1.Ss|KFO67989
6.9
32.3
35.7
43
33.7
45.9
34.8
48
33.2
33.4
33.8

MAD3
5.8
31
100
32.9
35.9
35
35.6
34.3
28
27.6
33.1

gi|1082474576|gb|OFY19591.1|
7
31.4
35.9
43.2
31.4
45
33.6
48.6
30.8
33.5
33

MAD2
6.1
100
31
30.7
30.2
31
31.2
31.2
25.8
27.7
32.6

Cpf1.Lb5|WP_016301126
7.8
32.8
36.5
38.2
34.2
45.5
35.8
43.6
30.7
35.7
32.5

gi|1088286736|gb|OHB41002.1|
6.7
30.6
35.3
42.4
33.2
44.7
32.1
46.8
30.7
32.6
32.4

gi|1094423310|emb|SER03894.1|
6.8
30.8
36.1
40.4
31.8
50.4
35.2
46.6
30.4
36.8
32.3

gi|493326531|ref|WP_006283774.1|
6.8
30.8
36.1
40.3
31.8
50.3
35.1
46.6
30.4
36.8
32.3

MAD8
7.6
31.2
34.3
40.4
32
41.6
32.8
100
30.1
32.1
31.7

Cpf1.Bot|WP_009217842
6.9
30.1
36.6
41.5
32.5
50.2
35.4
45.5
29.8
34.1
31.6

Cpf1.Li|WP_020988726
7.3
30.2
34.6
39.3
30.3
40.7
31.8
39.4
32.1
31.3
31.5

Cpf1.Pb|WP_044110123
6.3
31.4
31.8
36.1
30.8
45.7
30.4
39.4
27.7
33.5
31.5

gi|817911372|gb|AKG08867.1|
7.3
29.8
35
40.7
32.1
40.3
32.6
41.7
29.1
31
31.4

gi|1052838533|emb|SCH45297.1|
6.6
30.8
35.5
32
31.5
34.4
51.9
33.4
26.1
29
31.3

gi|1053713332|ref|WP_066040075.1|
7.2
29.6
33.2
39.6
29.8
49.1
32.2
41.4
30.1
32.4
31.3

gi|817909002|gb|AKG06878.1|
7.3
29.8
35
40.7
32
40.3
32.5
41.6
29.1
30.9
31.3

gi|1042201477|ref|WP_065256572.1|
7.2
29.5
35.2
40.6
31.9
40.1
32.7
41.6
29
30.8
31.2

MAD6
7.5
31
35
38.9
33.1
100
34.3
41.6
30.5
33.6
31

gi|490468773|ref|WP_004339290.1|
6.8
31.8
31.7
36.2
28.6
36.5
31.4
38.4
28.5
31.4
31

gi|565853704|ref|WP_023936172.1|
7.5
30.8
34.9
38.9
33.1
99.7
34.1
41.6
30.4
33.6
31

gi|739005707|ref|WP_036887416.1|
7.5
30.9
35
38.9
33
99.9
34.2
41.5
30.4
33.5
31

gi|739008549|ref|WP_036890108.1|
7.5
31
35
38.8
33
99.8
34.2
41.5
30.4
33.5
31

Cpf1.Ft|WP_014550095
7.1
31.9
33.8
40.3
29.7
39.4
34.1
41
29.8
32.5
30.8

gi|0504362993|ref|WP_014550095.1|
7.2
32.4
33.8
40.3
29.6
39.4
33.8
40.9
30.1
32.5
30.8

gi|0640557447|ref|WP_024988992.1|
6.6
31.4
34.8
40.7
31.2
48
34.1
45.1
28.8
35.2
30.8

gi|1098944113|ref|WP_071304624.1|
7.1
32.3
33.5
40.3
29.6
39.2
33.8
40.9
30.1
32.5
30.6

gi|0489124848|ref|WP_003034647.1|
7.1
32.3
33.9
40.9
29.9
39.2
33.9
40.9
29.9
32.2
30.6

gi|738967776|ref|WP_036851563.1|
6.8
29.4
33.1
35.5
28.9
40.3
30.7
35.9
28.7
31.3
30.5

MAD7
5.9
31.2
35.6
30.8
33.9
34.3
100
32.8
24.2
28.9
30.5

Cpf1.Lb6|WP_044910713
6.7
29.8
33.7
36.6
30.9
43
34
39.8
29.1
32.1
30.4

gi|1052961977|emb|SCH47915.1|
5.5
30.5
35.8
32.3
34
35
53.8
33.4
26.2
27.4
30.4

gi|817918353|gb|AKG14689.1|
7
29.1
34.4
39.8
31.7
40
32.4
41.1
28.4
30.1
30.3

gi|917059416|ref|WP_051666128.1|
6.9
29.9
31.5
35.7
31.6
41.8
32.9
39.1
30.1
34
30.2

gi|1011649201|ref|WP_062499108.1|
6.8
29
34.7
40.3
31.4
40.1
33.1
41.6
28.5
30.4
30.1

Cpf1.Pm|WP_018359861
6.3
29.2
32.3
34.2
27.4
38.7
29.4
35
27.2
30.1
30

gi|817922537|gb|AKG18099.1|
6.8
29.1
34.5
39.6
31.5
39.9
32.7
40.7
28.3
29.8
30

gi|769142322|ref|WP_044919442.1|
6.7
31
34.6
37.8
31.5
41.4
33.3
39.2
28
31.9
29.9

gi|1023176441|pdb|5ID6|A
6.7
29.7
31.3
35.5
31.3
41
32.6
38.5
29.7
33.3
29.8

gi|0491540987|ref|WP_005398606.1|
5.9
28.3
30.4
29.7
28.5
29
30.7
29.8
25.8
27.8
29.8

gi|652820612|ref|WP_027109509.1|
6.4
31.1
34
35.3
31.7
40.3
33.4
37.5
28.5
33.3
29.8

gi|502240446|ref|WP_012739647.1|
5.9
31.6
36.1
31.2
33
35.4
49.4
34
26.6
29.4
29.7

gi|524278046|emb|CDA41776.1|
5.8
31.6
36
31
33
35.4
50
34
26.6
29.5
29.7

gi|737831580|ref|WP_035798880.1|
6.2
31.3
34.8
38.1
31.5
42.1
33
39.6
28.4
32.4
29.7

gi|909652572|ref|WP_049895985.1|
6.9
30.7
34.2
37.2
30.8
41.5
34.2
38.7
28
32
29.7

MAD4
6.7
30.7
32.9
100
30.7
38.9
30.8
40.4
28.8
29.4
29.7

gi|942073049|ref|WP_055286279.1|
5.9
31.6
36.1
31.1
32.7
35
49.7
33.9
27.1
29.5
29.6

gi|654794505|ref|WP_028248456.1|
7.4
30.5
35.9
37.4
31.3
42.8
34.2
40.2
27.9
33.5
29.5

gi|933014786|emb|CUO47728.1|
5.6
31.3
34.9
31.2
31.5
32.4
46.7
30.6
25.4
27.7
29.4

gi|941887450|ref|WP_055224182.1|
5.6
31.4
35
31.3
31.6
32.5
46.6
30.7
25.3
27.8
29.4

gi|920071674|ref|WP_052943011.1|
6.3
31
31.8
38.8
31.8
41.3
33.8
42.6
29.8
34.7
29

MAD5
5.1
30.2
35.9
30.7
100
33.1
33.9
32
24.3
28.7
29

gi|1081462674|emb|SCZ76797.1|
6.9
30.4
33.5
34.7
29.7
40.1
30.5
37.4
27.3
32.5
28.9

gi|918722523|ref|WP_052585281.1|
7.4
27.5
30.5
35.7
28.3
35.2
28.5
36
26
27.1
28.8

gi|524816323|emb|CDF09621.1|
6.2
30
34.1
29.3
31.2
32.7
47.6
32.2
25.5
25.9
28.4

gi|941782328|ref|WP_055176369.1|
6.2
30.2
33.1
28.9
30.9
32
46.9
32.1
26
27.1
28.4

gi|942113296|ref|WP_055306762.1|
6.4
29.8
33.8
29.7
31.3
33.1
48
32.5
25.8
26.2
28.4

MAD11
6.4
27.7
27.6
29.4
28.7
33.6
28.9
32.1
26.2
100
27.8

gi|653158548|ref|WP_027407524.1|
5.9
26.4
28.1
33.5
27.4
32.5
27.8
32
27
26.8
27.6

gi|652963004|ref|WP_027216152.1|
6.6
30.3
32.5
33.2
30.4
38.2
29.6
34.6
25.9
30.5
27.2

gi|1083069650|gb|OGD68774.1|
6.2
25
24.3
26.6
23.1
28.1
23.2
26.4
45
24.9
27.1

gi|302483275|gb|EFL46285.1|
5.6
24.7
26.8
30.3
24.9
34.8
26
30.4
24.4
27.5
27.1

gi|915400855|ref|WP_050786240.1|
5.6
24.7
26.8
30.3
24.9
34.8
26
30.4
24.4
27.5
27.1

MAD10
5.6
25.8
28
28.8
24.3
30.5
24.2
30.1
100
26.2
26.6

gi|1101117967|gb|OIO75780.1|
6.1
26.8
26
27.3
24.3
28.1
24.4
28.2
44.1
25.4
26.1

g|11088204458|gb|OHA63117.1|
6.5
25.2
23.5
25.8
22.9
27
22
26.1
36.5
24.2
24.7

gi|809198071|ref|WP_046328599.1|
4.9
25.6
26.5
22.2
23.9
23.8
25.8
23.9
20.3
25.1
24

gi|1088079929|gb|OGZ45678.1|
5.6
21.9
23.8
26.9
23.4
27.8
23.3
26.7
28.8
24.7
23.5

gi|1101053499|gb|OIO15737.1|
5.9
23.1
26.2
25.2
23
26.4
25.1
26.5
29.2
23.2
23.4

gi|1101058058|gb|OIO19978.1|
5.4
21.2
22.8
23.6
20.6
25
20.7
25
25.9
22.2
23

gi|1088000848|gb|OGY73485.1|
5.7
23.5
25.2
25.5
23.9
27
25.1
25.6
31.6
23.6
22.9

gi|407014433|gb|EKE28449.1|
5.2
23.5
25.9
26.7
24.3
25.8
23
27.8
29.9
25.3
22.9

gi|818249855|gb|KKP36646.1|
6
21
20.7
23.5
20
24.2
21
24
24.6
21.8
22.6

gi|818703647|gb|KKT48220.1|
5.8
23.3
25
25.1
23.5
26.5
24.7
25.3
31.2
23.3
22.6

gi|818705786|gb|KKT50231.1|
5.8
23.1
24.6
24.7
22.9
26.2
24.2
24.8
30.8
22.9
22.2

gi|1083950632|gb|OGJ66851.1|
4.5
20
22.1
23.5
20.6
24.6
20
24
23.5
20.7
22.1

gi|1083932199|gb|OGJ49885.1|
6
20.4
20.2
22.6
19.3
23.3
20.6
23.2
23.9
21
21.8

gi|1083410735|gb|OGF20863.1|
5
21.7
23.3
25.5
23
25
22.7
25.9
27.2
22.4
21.5

gi|1011480927|ref|WP_062376669.1|
4.7
20.1
20.1
21.4
19.3
23.3
21.4
22
20.2
19.7
20.9

gi|818539593|gb|KKR91555.1|
5.1
19.8
21.6
22.1
20.5
22.9
21.2
22.8
24
20.5
19.9

gi|503048015|ref|WP_013282991.1|
5.1
18.8
20.7
15.3
19.7
18.9
19.3
17.7
15.9
19
19.2

gi|1096232746|ref|WP_071177645.1|
5
19.1
20.5
17.4
20.1
19.7
20.4
20.4
17.5
18.5
18.9

gi|769130404|ref|WP_044910712.1|
4.6
19.4
18.2
16.1
18.1
17.1
18.7
17.9
14.5
16.8
17.5

gi|1085569500|gb|OGX23684.1|
2.6
11.6
12.1
12.7
10.2
12.1
12.7
11.6
10.9
11.1
10.5

gi|818357062|gb|KKQ38176.1|
3.3
10
11.1
10.6
11.1
11.8
12.1
11.5
12.2
10.8
9.8

gi|745626763|gb|KIE18642.1|
3.7
9.4
11.7
11.1
11.1
12.5
11.9
11.9
10.2
10.6
8.8

MAD1
100
6.1
5.8
6.7
5.1
7.5
5.9
7.6
5.6
6.4
6.4

SpCas9
4
6.3
6.5
8.3
5.6
8.1
6.9
7.7
6.9
6.3
6.3

MAD12
6.4
32.6
33.1
29.7
29
31
30.5
31.7
26.6
27.8
100

Example 2: Expression of MAD Nucleases

Wild-type nucleic acid sequences for MAD1-MAD20 include SEQ ID NOs 21-40, respectively. These MAD nucleases were codon optimized for expression in E. coli and the codon optimized sequences are listed as SEQ ID NO: 41-60, respectively (summarized in Table 2).

Codon optimized MAD1-MAD20 were cloned into an expression construct comprising a constitutive or inducible promoter (eg., proB promoter SEQ ID NO: 83, or pBAD promoter SEQ ID NO: 81 or SEQ ID NO: 82) and an optional 6×-His tag (eg., FIG. 2). The generated MAD1-MAD2 expression constructs are provided as SEQ ID NOs: 61-80, respectively. The expression constructs as depicted in FIG. 2 were generated either by restriction/ligation-based cloning or homology-based cloning.

Example 3. Testing Guide Nucleic Acid Sequences Compatible with MAD Nucleases

In order to have a functioning targetable nuclease complex, a nucleic acid-guided nuclease and a compatible guide nucleic acid is needed. To determine the compatible guide nucleic acid sequence, specifically the scaffold sequence portion of the guide nucleic acid, multiple approaches were taken. First, scaffold sequences were looked for near the endogenous loci of each MAD nuclease. In some cases, such as with MAD2, no endogenous scaffold sequence was found. Therefore, we tested the compatibility of MAD2 with scaffold sequences found near the endogenous loci of the other MAD nucleases. A list of the MAD nucleases and corresponding endogenous scaffold sequences that were tested is listed in Table 2.

TABLE 2

Endogenous

Codon optimized

scaffold sequence

WT nucleic acid
nucleic acid
Amino acid
for guide nucleic

MAD nuclease
sequence
sequence
sequence
acid

MAD1
SEQ ID NO: 21
SEQ ID NO: 41
SEQ ID NO: 1
SEQ ID NO: 84

MAD2
SEQ ID NO: 22
SEQ ID NO: 42
SEQ ID NO: 2
None identified

MAD3
SEQ ID NO: 23
SEQ ID NO: 43
SEQ ID NO: 3
SEQ ID NO: 86

MAD4
SEQ ID NO: 24
SEQ ID NO: 44
SEQ ID NO: 4
SEQ ID NO: 87

MAD5
SEQ ID NO: 25
SEQ ID NO: 45
SEQ ID NO: 5
SEQ ID NO: 88

MAD6
SEQ ID NO: 26
SEQ ID NO: 46
SEQ ID NO: 6
SEQ ID NO: 89

MAD7
SEQ ID NO: 27
SEQ ID NO: 47
SEQ ID NO: 7
SEQ ID NO: 90

MAD8
SEQ ID NO: 28
SEQ ID NO: 48
SEQ ID NO: 8
SEQ ID NO: 91

MAD9
SEQ ID NO: 29
SEQ ID NO: 49
SEQ ID NO: 9
SEQ ID NO: 92;

SEQ ID NO: 103;

SEQ ID NO: 106

MAD10
SEQ ID NO: 30
SEQ ID NO: 50
SEQ ID NO: 10
SEQ ID NO: 93

MAD11
SEQ ID NO: 31
SEQ ID NO: 51
SEQ ID NO: 11
SEQ ID NO: 94

MAD12
SEQ ID NO: 32
SEQ ID NO: 52
SEQ ID NO: 12
SEQ ID NO: 95

MAD13
SEQ ID NO: 33
SEQ ID NO: 53
SEQ ID NO: 13
SEQ ID NO: 96;

SEQ ID NO: 105;

SEQ ID NO: 107

MAD14
SEQ ID NO: 34
SEQ ID NO: 54
SEQ ID NO: 14
SEQ ID NO: 97

MAD15
SEQ ID NO: 35
SEQ ID NO: 55
SEQ ID NO: 15
SEQ ID NO: 98

MAD16
SEQ ID NO: 36
SEQ ID NO: 56
SEQ ID NO: 16
SEQ ID NO: 99

MAD17
SEQ ID NO: 37
SEQ ID NO: 57
SEQ ID NO: 17
SEQ ID NO: 100

MAD18
SEQ ID NO: 38
SEQ ID NO: 58
SEQ ID NO: 18
SEQ ID NO: 101

MAD19
SEQ ID NO: 39
SEQ ID NO: 59
SEQ ID NO: 19
SEQ ID NO: 102

MAD20
SEQ ID NO: 40
SEQ ID NO: 60
SEQ ID NO: 20
SEQ ID NO: 103

Editing cassettes as depicted in FIG. 3 were generated to assess the functionality of the MAD nucleases and corresponding guide nucleic acids. Each editing cassette comprises an editing sequence and a promoter operably linked to an encoded guide nucleic acid. The editing cassettes further comprises primer sites (P1 and P2) on flanking ends. The guide nucleic acids comprised various scaffold sequences to be tested, as well as a guide sequence to guide the MAD nuclease to the target sequence for editing. The editing sequences comprised a PAM mutation and/or codon mutation relative to the target sequence. The mutations were flanked by regions of homology (homology arms or HA) which would allow recombination into the cleaved target sequence. (agcagctttatcatctgccg (SEQ ID No: 183); QQLYHLP (SEQ ID No: 184); agcagttataataactgccg (SEQ ID No: 186; and QQLLP (SEQ ID No: 206)

FIG. 4 depicts an experimental designed to test different MAD nuclease and guide nucleic acid combinations. An expression cassette encoding the MAD nuclease or the MAD nuclease protein were added to host cells along with various editing cassettes as described above. In this example, the guide nucleic acids were engineered to target the galK gene in the host cell, and the editing sequence was designed to mutate the targeted galK gene in order to turn the gene off, thereby allowing for screening of successfully edited cells. This design was used for identification of functional or compatible MAD nuclease and guide nucleic acid combinations. Editing efficiency was determined by qPCR to measure the editing plasmid in the recovered cells in a high-throughput manner. Validation of MAD11 and Cas9 primers is shown in FIGS. 14A and 14B. These results show that the selected primer pairs are orthogonal and allow quantitative measurement of input plasmid DNA

FIGS. 5A-5B is a depiction of a similar experimental design. In this case, the editing cassette (FIG. 5B) further comprises a selectable marker, in this case kanamycin resistance (kan) and the MAD nuclease expression vector (FIG. 5A) further comprises a selectable marker, in this case chloramphenicol resistance (Cm), and the lambda RED recombination system to aid homologous recombination (HR) of the editing sequence into the target sequence. A compatible MAD nuclease and guide nucleic acid combination will cause a double strand break in the target sequence if a PAM sequence is present. Since the editing sequence (eg. FIG. 3) contains a PAM mutation that is not recognized by the MAD nuclease, edited cells that contain the PAM mutation survive cleavage by the MAD nuclease, while wild-type non-edited cells die (FIG. 5C). The editing sequence further comprises a mutation in the galK gene that allows for screening of edited cells, while the MAD nuclease expression vector and editing cassette contain drug selection markers, allowing for selection of edited cells.

Using these methods, compatible guide nucleic acids for MAD1-MAD20 were tested. Twenty scaffold sequences were tested. The guide nucleic acids used in the experiments contained one of the twenty scaffold sequences, referred to as scaffold-1, scaffold-2, etc., and a guide sequence that targets the galK gene. Sequences for Scaffold-1 through Scaffold-20 are listed as SEQ ID NO: 84-103, respectively. It should be understood that the guide sequence of the guide nucleic acid is variable and can be engineered or designed to target any desired target sequence. Since MAD2 does not have an endogenous scaffold sequence to test, a scaffold sequence from a close homology (scaffold-2, SEQ ID NO: 85) was tested and found to be a non-functional pair, meaning MAD2 and scaffold-2 were not compatible. Therefore, MAD2 was tested with the other nineteen scaffold sequences, despite the low sequence homology between MAD2 and the other MAD nucleases.

This workflow could also be used to identify or test PAM sequences compatible with a given MAD nuclease. Another method for identifying a PAM site is described in the next example.

In general, for the assays described, transformations were carried out as follows. E. coli strains expressing the codon optimized MAD nucleases were grown overnight. Saturated cultures were diluted 1/100 and grown to an OD600 of 0.6 and induced by adding arabinose at a filing concentration of 0.4% and (if a temperature sensitive plasmid is used) shifting the culture to 42 degrees Celsius in a shaking water bath. Following induction, cells were chilled on ice for 15 min prior to washing thrice with ¼ the initial culture volume with 10% glycerol (for example, 50 mL washed for a 200 mL culture). Cells were resuspended in 1/100 the initial volume (for example, 2 mL for a 200 mL culture) and stores at −90 degrees Celsius until ready to use. To perform the compatibility and editing efficiency screens described here, 50 ng of editing cassette was transformed into cell aliquots by electroporation. Following electroporation, the cells were recovered in LB for 3 hours and 100 μL of cells were plated on Macconkey plates containing 1% galactose.

Editing efficiencies were determined by dividing the number of white colonies (edited cells) by the total number of white and red colonies (edited and non-edited cells).

Example 4. PAM Selection Assay

In order to generate a double strand break in a target sequence, a guide nucleic acid must hybridize to a target sequence, and the MAD nuclease must recognize a PAM sequence adjacent to the target sequence. If the guide nucleic acid hybridizes to the target sequence, but the MAD nuclease does not recognize a PAM site, then cleavage does not occur.

A PAM is MAD nuclease-specific and not all MAD nucleases necessarily recognize the same PAM. In order to assess the PAM site requirements for the MAD nucleases, an assay as depicted in FIGS. 6A-6C was performed.

FIG. 6A depicts a MAD nuclease expression vector as described elsewhere, which also contains a chloramphenicol resistance gene and the lambda RED recombination system.

FIG. 6B depicts a self-targeting editing cassette. The guided nucleic acid is designed to target the target sequence which is contained on the same nucleic acid molecule. The target sequence is flanked by random nucleotides, depicted by N4, meaning four random nucleotides on either end of the target sequence. It should be understood that any number of random nucleotides could also be used (for example, 3, 5, 6, 7, 8, etc). The random nucleotides serve as a library of potential PAMs.

FIG. 6C depicts the experimental design. Basically, the MAD nuclease expression vector and editing cassette comprising the random PAM sites were transformed into a host cell. If a functional targetable nuclease complex was formed and the MAD nuclease recognized a PAM site, then the editing cassette vector was cleaved and which leads to cell death. If a functional targetable complex was not formed or if the MAD nuclease did not recognize the PAM, then the target sequence was not cleaved and the cell survived. Next generation sequence (NGS) was then used to sequence the starting and final cell populations in order to determine what PAM sites were recognized by a given MAD nuclease. These recognized PAM sites were then used to determine a consensus or non-consensus PAM for a given MAD nuclease.

The consensus PAM for MAD1-MAD8, and MAD10-MAD12 was determined to be TTTN. The consensus PAM for MAD9 was determined to be NNG. The consensus PAM for MAD13-MAD15 was determined to be TTN. The consensus PAM for MAD16-MAD18 was determined to be TA. The consensus PAM for MAD19-MAD20 was determined to be TTCN.

Example 5: Testing Heterologous Guide Nucleic Acids

Editing efficiencies were tested for MAD1, MAD2, MAD4, and MAD7 and are depicted in FIG. 7A and FIG. 7B. Experiment details and editing efficiencies are summarized in Table 3. Editing efficiency was determined by dividing the number of edited cells by the total number of recovered cells. Various editing cassettes targeting the galK gene were used to allow screening of editing cells. The guide nucleic acids encoded on the editing cassette contained a guide sequence targeting the galK gene and one of various scaffold sequences in order to test the compatibility of the indicated MAD nuclease with the indicated scaffold sequence, as summarized in Table 3.

Editing efficiencies for compatible MAD nuclease and guide nucleic acids (comprising the indicated scaffold sequences) were observed to have between 75-100% editing efficiency. MAD2 had between a 75-100% editing efficiency and MAD7 had between a 97-100% editing efficiency.

MAD2 combined with scaffold-1, scaffold-2, scaffold-4, or scaffold-13 in these experiments results in 0% editing efficiency. These data imply that MAD2 did not form a functional complex with these tested guide nucleic acids and that MAD2 is not compatible with these scaffold sequences.

MAD7 combined with scaffold-1, scaffold-2, scaffold-4, or scaffold-13 in these experiments results in 0% editing efficiency. These data imply that MAD7 did not form a functional complex with these tested guide nucleic acids and that MAD7 is not compatible with these scaffold sequences.

For MAD1 and MAD4, all tested guide nucleic acid combinations resulted in 0% editing efficiency, implying that MAD1 and MAD4 did not form a functional complex with any of the tested guide nucleic acids. These data also imply that MAD1 and MAD4 are not compatible with the tested scaffold sequences.

Combined, these data highlight the unpredictability of finding a compatible MAD nuclease and scaffold sequence pair in order to form a functional targetable nuclease complex. Some tested MAD nucleases did not function with any tested scaffold sequence. Some tested MAD nucleases only functioned with some tested scaffold sequences and not with others.

TABLE 3

Editing

Nucleic acid-
Guide nucleic acid scaffold
sequence

Editing

#
guided nuclease
sequence
mutation
Target gene
efficiency

1
MAD1
Scaffold-1; SEQ ID NO: 84
L80**
galK
0%

2
MAD1
Scaffold-2; SEQ ID NO: 85
Y145**
galK
0%

3
MAD1
Scaffold-4; SEQ ID NO: 87
Y145**
galK
0%

4
MAD1
Scaffold-10; SEQ ID NO: 93
Y145**
galK
0%

5
MAD1
Scaffold-11; SEQ ID NO: 94
L80**
galK
0%

6
MAD1
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
0%

7
MAD1
Scaffold-13; SEQ ID NO: 96
Y145**
galK
0%

8
MAD1
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
0%

9
MAD2
Scaffold-10; SEQ ID NO: 93
L80**
galK
0%

10
MAD2
Scaffold-10; SEQ ID NO: 93
Y145**
galK
100%

11
MAD2
Scaffold-11; SEQ ID NO: 94
L80**
galK
98%

12
MAD2
Scaffold-11; SEQ ID NO: 94
Y145**
galK
99%

13
MAD2
Scaffold-12; SEQ ID NO: 95
Y145**
galK
98%

14
MAD2
Scaffold-12; SEQ ID NO: 95
Y145**
galK
0%

15
MAD2
Scaffold-13; SEQ ID NO: 96
Y145**
galK
0%

16
MAD2
Scaffold-1; SEQ ID NO: 84
L80**
galK
0%

17
MAD2
Scaffold-2; SEQ ID NO: 85
Y145**
galK
0%

18
MAD2
Scaffold-2; SEQ ID NO: 85
Y145**
galK
0%

19
MAD2
Scaffold-4; SEQ ID NO: 87
Y145**
galK
0%

20
MAD2
Scaffold-5; SEQ ID NO: 88
L80**
galK
99%

21
MAD2
Scaffold-12; SEQ ID NO: 95
89**
galK
0%

22
MAD2
Scaffold-12; SEQ ID NO: 95
70**
galK
75%

23
MAD2
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
79%

24
MAD4
Scaffold-1; SEQ ID NO: 84
L80**
galK
0%

25
MAD4
Scaffold-2; SEQ ID NO: 85
Y145**
galK
0%

26
MAD4
Scaffold-4; SEQ ID NO: 87
Y145**
galK
0%

27
MAD4
Scaffold-10; SEQ ID NO: 93
Y145**
galK
0%

28
MAD4
Scaffold-11; SEQ ID NO: 94
L80**
galK
0%

29
MAD4
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
0%

30
MAD4
Scaffold-13; SEQ ID NO: 96
Y145**
galK
0%

31
MAD4
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
0%

32
MAD7
Scaffold-1; SEQ ID NO: 84
L80**
galK
0%

33
MAD7
Scaffold-2; SEQ ID NO: 85
Y145**
galK
0%

34
MAD7
Scaffold-4; SEQ ID NO: 87
Y145**
galK
0%

35
MAD7
Scaffold-10; SEQ ID NO: 93
Y145**
galK
100%

36
MAD7
Scaffold-11; SEQ ID NO: 94
L80**
galK
97%

37
MAD7
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
0%

38
MAD7
Scaffold-13; SEQ ID NO: 96
Y145**
galK
0%

39
MAD7
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK
0%

Example 6. Assessment of MAD2 and MAD7

The ability of MAD2 and MAD7 to function with heterologous guide nucleic acids were tested using a similar experimental design as described above.

The compatibility of MAD2 with other scaffold sequences was tested and the results of an experiment are depicted in FIG. 8. The MAD nucleases, guide nucleic acid scaffold sequences, and editing sequences used in this experiment are summarized in Table 4.

The compatibility of MAD7 with other scaffold sequences was tested and the results of an experiment are depicted in FIG. 9. The MAD nucleases, guide nucleic acid scaffold sequences, and editing sequences used in this experiment are summarized in Table 5.

TABLE 4

Editing

Nucleic acid-
Guide nucleic acid scaffold
sequence
Target

#
guided nuclease
sequence
mutation
gene

1
MAD2
Scaffold-12; SEQ ID NO: 95
N89KpnI
galK

2
MAD2
Scaffold-10; SEQ ID NO: 93
L80**
galK

3
MAD2
Scaffold-5; SEQ ID NO: 88
L80**
galK

4
MAD2
Scaffold-12; SEQ ID NO: 95
D70KpnI
galK

5
MAD2
Scaffold-12; SEQ ID NO: 95
Y145**
galK

6
MAD2
Scaffold-11; SEQ ID NO: 94
Y145**
galK

7
MAD2
Scaffold-10; SEQ ID NO: 93
Y145**
galK

8
MAD2
Scaffold-12; SEQ ID NO: 95
L10KpnI
galK

9
MAD2
Scaffold-11; SEQ ID NO: 94
L80**
galK

10
SpCas9
S. pyogenese gRNA
Y145**
galK

11
MAD2
Scaffold-2; SEQ ID NO: 85
Y145**
galK

12
MAD2
Scaffold-4; SEQ ID NO: 87
Y145**
galK

13
MAD2
Scaffold-1; SEQ ID NO: 84
L80**
galK

14
MAD2
Scaffold-13; SEQ ID NO: 96
Y145**
galK

TABLE 5

Editing

Nucleic acid-
Guide nucleic acid scaffold
sequence
Target

#
guided nuclease
sequence
mutation
gene

1
MAD7
Scaffold-1; SEQ ID NO: 84
L80**
galK

2
MAD7
Scaffold-2; SEQ ID NO: 85
Y145**
galK

3
MAD7
Scaffold-4; SEQ ID NO: 87
Y145**
galK

4
MAD7
Scaffold-10; SEQ ID NO: 93
Y145**
galK

5
MAD7
Scaffold-11; SEQ ID NO: 95
L80**
galK

In another experiment, transformation efficiencies (FIG. 10B) were determined by calculating the total number of recovered cells compared to the start number of cells. An example plate image is depicted in FIG. 10C. Editing efficiencies (FIG. 10A) were determined by calculating the ratio of editing colonies (white colonies, edited galK gene) versus total colonies.

In this example (FIG. 10A-10C), cells expressing galK were transformed with expression constructs expressing either MAD2 or MAD7 and a corresponding editing cassette comprising a guide nucleic acid targeting the galK gene. The guide nucleic acid was comprised of a guide sequence targeting the galK gene and the scaffold-12 sequence (SEQ ID NO: 95).

In the depicted example, MAD2 and MAD7 has a lower transformation efficiency compared to S. pyogenes Cas9, though the editing efficiency of MAD2 and MAD7 was slightly higher than S. pyogenes Cas9.

FIG. 11 depicts the sequencing results from select colonies recovered from the assay described above. The target sequence was in the galK coding sequence (CDS). The TTTN PAM is shown as the reverse complement (wild-type NAAA, mutated NGAA). The mutations targeted by the editing sequence are labeled as target codons. Changes compared to the wild-type sequence are highlighted. In these experiments, the scaffold-12 sequence (SEQ ID NO: 95) was used. The guide sequence of the guide nucleic acid targeted the galK gene.

Six of the seven depicted sequences from the MAD2 experiment contained the designed PAM mutation and designed mutations in the target codons of galK, which one sequences colony maintained the wild-type PAM and wild-type target codons while also containing an unintended mutation upstream of the target site.

Two of the four depicted sequences from the MAD7 experiment contained the designed PAM mutation and mutated target codons. One colony comprises a wildtype sequence, while another contained a deletion of eight nucleotides upstream of the target sequence.

FIG. 12 depicts results from another experiment testing the ability to recover edited cells. In Experiment 0, the MAD2 nuclease was used with a guide nucleic acid comprising scaffold-11 sequence and a guide sequence targeting galK. The editing cassette comprised an editing sequence designed to incorporate an L80** mutation into galK, thereby allowing screening of the edited cells. In experiment 1, the MAD2 nuclease was used with a guide nucleic acid comprising scaffold-12 sequence and a guide sequence targeting galK. The editing cassette comprised an editing sequence designed to incorporate an L10KpnI mutation into galK. In both experiments, a negative control plasmid a guide nucleic acid that is not compatible with MAD2 was included in the transformations. Following transformation, the ratio of the compatible editing cassette (those containing scaffold-11 or scaffold-12 guide nucleic acids) to the non-compatible editing cassette (negative control) was measure. The experiments were done in the presence or absence of selection. The results show that more compatible editing cassette containing cells were recovered compared to the non-compatible editing cassette, and this result is magnified when selection is used.

Example 7. Guide Nucleic Acid Characterization

The sequences of scaffolds 1-8, and 10-12 (SEQ ID NO: 84-91, and 93-95) were aligned and are depicted in FIG. 13A. Nucleotides that match the consensus sequence are faded, while those diverging from the consensus sequence are visible. The predicted pseudoknot region is indicated. Without being bound by theory, the region 5′ of the pseudoknot may be influence binding and/or kinetics of the nucleic acid-guided nuclease. As is shown in FIG. 13A, in general, there appears to be less variability in the pseudoknot region (e.g., SEQ ID NO: 172-181) as compared to the sequence outside of the pseudoknot region.

FIG. 13B shows a preliminary model of MAD2 and MAD12 complexed with a guide nucleic acid (in this example, a guide RNA) and target sequence (DNA).

Example 8. Editing Efficiency of the MAD Nucleases

A plate-based editing efficiency assay and a molecular editing efficiency assay were used to test editing efficiency of various MAD nuclease and guide nucleic acid combinations.

FIG. 15 depicts quantification of the data obtained using the molecular editing efficiency assay using MAD2 nuclease with a guide nucleic acid comprising scaffold-12 and a guide sequencing targeting galK. The indicated mutations were incorporated into the galK using corresponding editing cassettes containing the mutation. FIG. 16 shows the comparison of the editing efficiencies determined by the plate-based assay using white and red colonies as described previously, and the molecular editing efficiency assay. As shown in FIG. 16, the editing efficiencies as determined by the two separate assays are consistent.

Example 9. Trackable Editing

Genetic edits can be tracked by the use of a barcode. A barcode can be incorporated into or near the edit site as described in the present specification. When multiple rounds of engineering are being performed, with a different edit being made in each round, it may be beneficial to insert a barcode in a common region during each round of engineering, this way one could sequence a single site and get the sequences of all of the barcodes from each round without the need to sequence each edited site individually. FIGS. 17A-17C, 18, and 19 depict examples of such trackable engineering workflows.

As depicted in FIG. 17A, a cell expressing a MAD nuclease is transformed with a plasmid containing an editing cassette and a recording cassette. The editing cassette contains a PAM mutation and a gene edit. The recorder cassette comprises a barcode, in this case 15N. Both the editing cassette and recording cassette each comprise a guide nucleic acid to a distinct target sequence. Within a library of such plasmids, the recorder cassette for each round can contain the same guide nucleic acid, such that the first round barcode is inserted into the same location across all variants, regardless of what editing cassette and corresponding gene edit is used. The correlation between the barcode and editing cassette is determined beforehand though such that the edit can be identified by sequencing the barcode. FIG. 17B shows an example of a recording cassette designed to delete a PAM site while incorporating a 15N barcode (actatcaatg ggctaactnnnnnnnnnnnnnnntgaaacatctgcaactgcg (SEQ ID No: 203); actatcaatgggctaactac gttcgtggcgtggtgaaacatctgcaactgcg (SEQ ID No: 204). The deleted PAM is used to enrich for edited cells since mutated PAM cells escape cell death while cells containing a wild-type PAM sequence are killed. Fire 21 C depicts how sequencing the barcode region can be used to identify which edit is comprised within each cell.

A similar approach is depicted in FIG. 18. In this case, the recorder cassette from each round is designed to target a sequence adjacent to the previous round, and each time, a new PAM site is deleted by the recorder cassette. The result is a barcode array with the barcodes from each round that can be sequenced to confirm each round of engineering took place and to determine which combination of mutations are contained in the cell, and in which order the mutations were made. Each successive recorder cassette can be designed to be homologous on one end to the region comprising the mutated PAM from the previous round, which could increase the efficiency of getting fully edited cells at the end of the experiment. In other examples, the recorder cassette is designed to target a unique landing site that was incorporated by the previous recorder cassette. This increases the efficiency of recovering cells containing all of the desired mutations since the subsequent recorder cassette and barcode can only target a cell that has successfully completed the previous round of engineering.

FIG. 19 depicts another approach that allows the recycling of selectable markers or to otherwise cure the cell of the plasmid form the previous round of engineering. In this case, the transformed plasmid containing a guide nucleic acid designed to target a selectable marker or other unique sequence in the plasmid form the previous round of engineering.

SEQUENCE LISTING
Table 6

TABLE 6

SEQUENCE LISTING

SEQ

ID

NO:
Sequence

SEQ
MGKMYYLGLDIGTNSVGYAVTDPSYHLLKFKGEPMWGAHVFAAGNQSAERRSFRT

ID
SRRRLDRRQQRVKLVQEIFAPVISPIDPRFFIRLHESALWRDDVAETDKHIFFND

NO:
PTYTDKEYYSDYPTIHHLIVDLMESSEKHDPRLVYLAVAWLVAHRGHFLNEVDKD

1
NIGDVLSFDAFYPEFLAFLSDNGVSPWVCESKALQATLLSRNSVNDKYKALKSLI

FGSQKPEDNFDANISEDGLIQLLAGKKVKVNKLFPQESNDASFTLNDKEDAIEEI

LGTLTPDECEWIAHIRRLFDWAIMKHALKDGRTISESKVKLYEQHHHDLTQLKYF

VKTYLAKEYDDIFRNVDSETTKNYVAYSYHVKEVKGTLPKNKATQEEFCKYVLGK

VKNIECSEADKVDFDEMIQRLTDNSFMPKQVSGENRVIPYQLYYYELKTILNKAA

SYLPFLTQCGKDAISNQDKLLSIMTFRIPYFVGPLRKDNSEHAWLERKAGKIYPW

NFNDKVDLDKSEEAFIRRMTNTCTYYPGEDVLPLDSLIYEKFMILNEINNIRIDG

YPISVDVKQQVFGLFEKKRRVTVKDIQNLLLSLGALDKHGKLTGIDTTIHSNYNT

YHHFKSLMERGVLTRDDVERIVERMTYSDDTKRVRLWLNNNYGTLTADDVKHISR

LRKHDFGRLSKMFLTGLKGVHKETGERASILDFMWNTNDNLMQLLSECYTFSDEI

TKLQEAYYAKAQLSLNDFLDSMYISNAVKRPIYRTLAVVNDIRKACGTAPKRIFI

EMARDGESKKKRSVTRREQIKNLYRSIRKDFQQEVDFLEKILENKSDGQLQSDAL

YLYFAQLGRDMYTGDPIKLEHIKDQSFYNIDHIYPQSMVKDDSLDNKVLVQSEIN

GEKSSRYPLDAAIRNKMKPLWDAYYNHGLISLKKYQRLTRSTPFTDDEKWDFINR

QLVETRQSTKALAILLKRKFPDTEIVYSKAGLSSDFRHEFGLVKSRNINDLHHAK

DAFLAIVTGNVYHERFNRRWFMVNQPYSVKTKTLFTHSIKNGNFVAWNGEEDLGR

IVKMLKQNKNTIHFTRFSFDRKEGLFDIQPLKASTGLVPRKAGLDVVKYGGYDKS

TAAYYLLVRFTLEDKKTQHKLMMIPVEGLYKARIDHDKEFLTDYAQTTISEILQK

DKQKVINIMFPMGTRHIKLNSMISIDGFYLSIGGKSSKGKSVLCHAMVPLIVPHK

IECYIKAMESFARKFKENNKLRIVEKFDKITVEDNLNLYELFLQKLQHNPYNKFF

STQFDVLTNGRSTFTKLSPEEQVQTLLNILSIFKTCRSSGCDLKSINGSAQAARI

MISADLTGLSKKYSDIRLVEQSASGLFVSKSQNLLEYL*

SEQ
MSSLTKFTNKYSKQLTIKNELIPVGKTLENIKENGLIDGDEQLNENYQKAKIIVD

ID
DFLRDFINKALNNTQIGNWRELADALNKEDEDNIEKLQDKIRGIIVSKFETFDLF

NO:
SSYSIKKDEKIIDDDNDVEEEELDLGKKTSSFKYIFKKNLFKLVLPSYLKTTNQD

2
KLKIISSFDNFSTYFRGFFENRKNIFTKKPISTSIAYRIVHDNFPKFLDNIRCFN

VWQTECPQLIVKADNYLKSKNVIAKDKSLANYFTVGAYDYFLSQNGIDFYNNIIG

GLPAFAGHEKIQGLNEFINQECQKDSELKSKLKNRHAFKMAVLFKQILSDREKSF

VIDEFESDAQVIDAVKNFYAEQCKDNNVIFNLLNLIKNIAFLSDDELDGIFIEGK

YLSSVSQKLYSDWSKLRNDIEDSANSKQGNKELAKKIKTNKGDVEKAISKYEFSL

SELNSIVHDNTKFSDLLSCTLHKVASEKLVKVNEGDWPKHLKNNEEKQKIKEPLD

ALLEIYNTLLIFNCKSFNKNGNFYVDYDRCINELSSVVYLYNKTRNYCTKKPYNT

DKFKLNFNSPQLGEGFSKSKENDCLTLLFKKDDNYYVGIIRKGAKINFDDTQAIA

DNTDNCIFKMNYFLLKDAKKFIPKCSIQLKEVKAHFKKSEDDYILSDKEKFASPL

VIKKSTFLLATAHVKGKKGNIKKFQKEYSKENPTEYRNSLNEWIAFCKEFLKTYK

AATIFDITTLKKAEEYADIVEFYKDVDNLCYKLEFCPIKTSFIENLIDNGDLYLF

RINNKDFSSKSTGTKNLHTLYLQAIFDERNLNNPTIMLNGGAELFYRKESIEQKN

RITHKAGSILVNKVCKDGTSLDDKIRNEIYQYENKFIDTLSDEAKKVLPNVIKKE

ATHDITKDKRFTSDKFFFHCPLTINYKEGDTKQFNNEVLSFLRGNPDINIIGIDR

GERNLIYVTVINQKGEILDSVSFNTVTNKSSKIEQTVDYEEKLAVREKERIEAKR

SWDSISKIATLKEGYLSAIVHEICLLMIKHNAIVVLENLNAGFKRIRGGLSEKSV

YQKFEKMLINKLNYFVSKKESDWNKPSGLLNGLQLSDQFESFEKLGIQSGFIFYV

PAAYTSKIDPTTGFANVLNLSKVRNVDAIKSFFSNFNEISYSKKEALFKFSFDLD

SLSKKGFSSFVKFSKSKWNVYTFGERIIKPKNKQGYREDKRINLTFEMKKLLNEY

KVSFDLENNLIPNLTSANLKDTFWKELFFIFKTTLQLRNSVTNGKEDVLISPVKN

AKGEFFVSGTHNKTLPQDCDANGAYHIALKGLMILERNNLVREEKDTKKIMAISN

VDWFEYVQKRRGVL*

SEQ
MNNYDEFTKLYPIQKTIRFELKPQGRTMEHLETFNFFEEDRDRAEKYKILKEAID

ID
EYHKKFIDEHLTNMSLDWNSLKQISEKYYKSREEKDKKVFLSEQKRMRQEIVSEF

NO:
KKDDRFKDLFSKKLFSELLKEEIYKKGNHQEIDALKSFDKFSGYFIGLHENRKNM

3
YSDGDEITAISNRIVNENFPKFLDNLQKYQEARKKYPEWIIKAESALVAHNIKMD

EVFSLEYFNKVLNQEGIQRYNLALGGYVTKSGEKMMGLNDALNLAHQSEKSSKGR

IHMTPLFKQILSEKESFSYIPDVFTEDSQLLPSIGGFFAQIENDKDGNIFDRALE

LISSYAEYDTERIYIRQADINRVSNVIFGEWGTLGGLMREYKADSINDINLERTC

KKVDKWLDSKEFALSDVLEAIKRTGNNDAFNEYISKMRTAREKIDAARKEMKFIS

EKISGDEESIHIIKTLLDSVQQFLHFFNLFKARQDIPLDGAFYAEFDEVHSKLFA

IVPLYNKVRNYLTKNNLNTKKIKLNFKNPTLANGWDQNKVYDYASLIFLRDGNYY

LGIINPKRKKNIKFEQGSGNGPFYRKMVYKQIPGPNKNLPRVFLTSTKGKKEYKP

SKEIIEGYEADKHIRGDKFDLDFCHKLIDFFKESIEKHKDWSKFNFYFSPTESYG

DISEFYLDVEKQGYRMHFENISAETIDEYVEKGDLFLFQIYNKDFVKAATGKKDM

HTIYWNAAFSPENLQDVVVKLNGEAELFYRDKSDIKEIVHREGEILVNRTYNGRT

PVPDKIHKKLTDYHNGRTKDLGEAKEYLDKVRYFKAHYDITKDRRYLNDKIYFHV

PLTLNFKANGKKNLNKMVIEKFLSDEKAHIIGIDRGERNLLYYSIIDRSGKIIDQ

QSLNVIDGFDYREKLNQREIEMKDARQSWNAIGKIKDLKEGYLSKAVHEITKMAI

QYNAIVVMEELNYGFKRGRFKVEKQIYQKFENMLIDKMNYLVFKDAPDESPGGVL

NAYQLTNPLESFAKLGKQTGILFYVPAAYTSKIDPTTGFVNLFNTSSKTNAQERK

EFLQKFESISYSAKDGGIFAFAFDYRKFGTSKTDHKNVWTAYTNGERMRYIKEKK

RNELFDPSKEIKEALTSSGIKYDGGQNILPDILRSNNNGLIYTMYSSFIAAIQMR

VYDGKEDYIISPIKNSKGEFFRTDPKRRELPIDADANGAYNIALRGELTMRAIAE

KFDPDSEKMAKLELKHKDWFEFMQTRGD*

SEQ
MTKTFDSEFFNLYSLQKTVRFELKPVGETASFVEDFKNEGLKRVVSEDERRAVDY

ID
QKVKEIIDDYHRDFIEESLNYFPEQVSKDALEQAFHLYQKLKAAKVEEREKALKE

NO:
WEALQKKLREKVVKCFSDSNKARFSRIDKKELIKEDLINWLVAQNREDDIPTVET

4
FNNFTTYFTGFHENRKNIYSKDDHATAISFRLIHENLPKFFDNVISENKLKEGFP

ELKFDKVKEDLEVDYDLKHAFEIEYFVNFVTQAGIDQYNYLLGGKTLEDGTKKQG

MNEQINLFKQQQTRDKARQIPKLIPLFKQILSERTESQSFIPKQFESDQELFDSL

QKLHNNCQDKFTVLQQAILGLAEADLKKVFIKTSDLNALSNTIFGNYSVFSDALN

LYKESLKTKKAQEAFEKLPAHSIHDLIQYLEQFNSSLDAEKQQSTDTVLNYFIKT

DELYSRFIKSTSEAFTQVQPLFELEALSSKRRPPESEDEGAKGQEGFEQIKRIKA

YLDTLMEAVHFAKPLYLVKGRKMIEGLDKDQSFYEAFEMAYQELESLIIPIYNKA

RSYLSRKPFKADKFKINFDNNTLLSGWDANKETANASILFKKDGLYYLGIMPKGK

TFLFDYFVSSEDSEKLKQRRQKTAEEALAQDGESYFEKIRYKLLPGASKMLPKVF

FSNKNIGFYNPSDDILRIRNTASHTKNGTPQKGHSKVEFNLNDCHKMIDFFKSSI

QKHPEWGSFGFTFSDTSDFEDMSAFYREVENQGYVISFDKIKETYIQSQVEQGNL

YLFQIYNKDFSPYSKGKPNLHTLYWKALFEEANLNNVVAKLNGEAEIFFRRHSIK

ASDKVVHPANQAIDNKNPHTEKTQSTFEYDLVKDKRYTQDKFFFHVPISLNFKAQ

GVSKFNDKVNGFLKGNPDVNIIGIDRGERHLLYFTVVNQKGEILVQESLNTLMSD

KGHVNDYQQKLDKKEQERDAARKSWTTVENIKELKEGYLSHVVHKLAHLIIKYNA

IVCLEDLNFGFKRGRFKVEKQVYQKFEKALIDKLNYLVFKEKELGEVGHYLTAYQ

LTAPFESFKKLGKQSGILFYVPADYTSKIDPTTGFVNFLDLRYQSVEKAKQLLSD

FNAIRFNSVQNYFEFEIDYKKLTPKRKVGTQSKWVICTYGDVRYQNRRNQKGHWE

TEEVNVTEKLKALFASDSKTTTVIDYANDDNLIDVILEQDKASFFKELLWLLKLT

MTLRHSKIKSEDDFILSPVKNEQGEFYDSRKAGEVWPKDADANGAYHIALKGLWN

LQQINQWEKGKTLNLAIKNQDWFSFIQEKPYQE*

SEQ
MHTGGLLSMDAKEFTGQYPLSKTLRFELRPIGRTWDNLEASGYLAEDRHRAECYP

ID
RAKELLDDNHRAFLNRVLPQIDMDWHPIAEAFCKVHKNPGNKELAQDYNLQLSKR

NO:
RKEISAYLQDADGYKGLFAKPALDEAMKIAKENGNESDIEVLEAFNGFSVYFTGY

5
HESRENIYSDEDMVSVAYRITEDNFPRFVSNALIFDKLNESHPDIISEVSGNLGV

DDIGKYFDVSNYNNFLSQAGIDDYNHIIGGHTTEDGLIQAFNVVLNLRHQKDPGF

EKIQFKQLYKQILSVRTSKSYIPKQFDNSKEMVDCICDYVSKIEKSETVERALKL

VRNISSFDLRGIFVNKKNLRILSNKLIGDWDAIETALMHSSSSENDKKSVYDSAE

AFTLDDIFSSVKKFSDASAEDIGNRAEDICRVISETAPFINDLRAVDLDSLNDDG

YEAAVSKIRESLEPYMDLFHELEIFSVGDEFPKCAAFYSELEEVSEQLIEIIPLE

NKARSFCTRKRYSTDKIKVNLKFPTLADGWDLNKERDNKAAILRKDGKYYLAILD

MKKDLSSIRTSDEDESSFEKMEYKLLPSPVKMLPKIFVKSKAAKEKYGLTDRMLE

CYDKGMHKSGSAFDLGFCHELIDYYKRCIAEYPGWDVFDFKFRETSDYGSMKEFN

EDVAGAGYYMSLRKIPCSEVYRLLDEKSIYLFQIYNKDYSENAHGNKNMHTMYWE

GLFSPQNLESPVFKLSGGAELFFRKSSIPNDAKTVHPKGSVLVPRNDVNGRRIPD

SIYRELTRYFNRGDCRISDEAKSYLDKVKTKKADHDIVKDRRFTVDKMMFHVPIA

MNFKAISKPNLNKKVIDGIIDDQDLKIIGIDRGERNLIYVTMVDRKGNILYQDSL

NILNGYDYRKALDVREYDNKEARRNWTKVEGIRKMKEGYLSLAVSKLADMIIENN

AIIVMEDLNHGFKAGRSKIEKQVYQKFESMLINKLGYMVLKDKSIDQSGGALHGY

QLANHVTTLASVGKQCGVIFYIPAAFTSKIDPTTGFADLFALSNVKNVASMREFF

SKMKSVIYDKAEGKFAFTFDYLDYNVKSECGRTLWTVYTVGERFTYSRVNREYVR

KVPTDIIYDALQKAGISVEGDLRDRIAESDGDTLKSIFYAFKYALDMRVENREED

YIQSPVKNASGEFFCSKNAGKSLPQDSDANGAYNIALKGILQLRMLSEQYDPNAE

SIRLPLITNKAWLTFMQSGMKTWKN*

SEQ
MDSLKDFTNLYPVSKTLRFELKPVGKTLENIEKAGILKEDEHRAESYRRVKKIID

ID
TYHKVFIDSSLENMAKMGIENEIKAMLQSFCELYKKDHRTEGEDKALDKIRAVLR

NO:
GLIVGAFTGVCGRRENTVQNEKYESLFKEKLIKEILPDFVLSTEAESLPFSVEEA

6
TRSLKEFDSFTSYFAGFYENRKNIYSTKPQSTAIAYRLIHENLPKFIDNILVFQK

IKEPIAKELEHIRADFSAGGYIKKDERLEDIFSLNYYIHVLSQAGIEKYNALIGK

IVTEGDGEMKGLNEHINLYNQQRGREDRLPLFRPLYKQILSDREQLSYLPESFEK

DEELLRALKEFYDHIAEDILGRTQQLMTSISEYDLSRIYVRNDSQLTDISKKMLG

DWNAIYMARERAYDHEQAPKRITAKYERDRIKALKGEESISLANLNSCIAFLDNV

RDCRVDTYLSTLGQKEGPHGLSNLVENVFASYHEAEQLLSFPYPEENNLIQDKDN

VVLIKNLLDNISDLQRFLKPLWGMGDEPDKDERFYGEYNYIRGALDQVIPLYNKV

RNYLTRKPYSTRKVKLNFGNSQLLSGWDRNKEKDNSCVILRKGQNFYLAIMNNRH

KRSFENKVLPEYKEGEPYFEKMDYKFLPDPNKMLPKVFLSKKGIEIYKPSPKLLE

QYGHGTHKKGDTFSMDDLHELIDFFKHSIEAHEDWKQFGFKFSDTATYENVSSFY

REVEDQGYKLSFRKVSESYVYSLIDQGKLYLFQIYNKDFSPCSKGTPNLHTLYWR

MLFDERNLADVIYKLDGKAEIFFREKSLKNDHPTHPAGKPIKKKSRQKKGEESLF

EYDLVKDRHYTMDKFQFHVPITMNFKCSAGSKVNDMVNAHIREAKDMHVIGIDRG

ERNLLYICVIDSRGTILDQISLNTINDIDYHDLLESRDKDRQQERRNWQTIEGIK

ELKQGYLSQAVHRIAELMVAYKAVVALEDLNMGFKRGRQKVESSVYQQFEKQLID

KLNYLVDKKKRPEDIGGLLRAYQFTAPFKSFKEMGKQNGFLFYIPAWNTSNIDPT

TGFVNLFHAQYENVDKAKSFFQKFDSISYNPKKDWFEFAFDYKNFTKKAEGSRSM

WILCTHGSRIKNFRNSQKNGQWDSEEFALTEAFKSLFVRYEIDYTADLKTAIVDE

KQKDFFVDLLKLFKLTVQMRNSWKEKDLDYLISPVAGADGRFFDTREGNKSLPKD

ADANGAYNIALKGLWALRQIRQTSEGGKLKLAISNKEWLQFVQERSYEKD*

SEQ
MNNGTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGIIKEDELRGENRQILK

ID
DIMDDYYRGFISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKEQTEYRKAIH

NO:
KKFANDDRFKNMFSAKLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSFK

7
DYFKNRANCFSADDISSSSCHRIVNDNAEIFFSNALVYRRIVKSLSNDDINKISG

DMKDSLKEMSLEEIYSYEKYGEFITQEGISFYNDICGKVNSFMNLYCQKNKENKN

LYKLQKLHKQILCIADTSYEVPYKFESDEEVYQSVNGFLDNISSKHIVERLRKIG

DNYNGYNLDKIYIVSKFYESVSQKTYRDWETINTALEIHYNNILPGNGKSKADKV

KKAVKNDLQKSITEINELVSNYKLCSDDNIKAETYIHEISHILNNFEAQELKYNP

EIHLVESELKASELKNVLDVIMNAFHWCSVFMTEELVDKDNNFYAELEEIYDEIY

PVISLYNLVRNYVTQKPYSTKKIKLNFGIPTLADGWSKSKEYSNNAIILMRDNLY

YLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLLPGPNKMIPKVFLSSKTGVET

YKPSAYILEGYKQNKHIKSSKDFDITFCHDLIDYFKNCIAIHPEWKNFGFDFSDT

STYEDISGFYREVELQGYKIDWTYISEKDIDLLQEKGQLYLFQIYNKDFSKKSTG

NDNLHTMYLKNLFSEENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILVNRTY

EAEEKDQFGNIQIVRKNIPENIYQELYKYFNDKSDKELSDEAAKLKNVVGHHEAA

TNIVKDYRYTYDKYFLHMPITINFKANKTGFINDRILQYIAKEKDLHVIGIDRGE

RNLIYVSVIDTCGNIVEQKSFNIVNGYDYQIKLKQQEGARQIARKEWKEIGKIKE

IKEGYLSLVIHEISKMVIKYNAIIAMEDLSYGFKKGRFKVERQVYQKFETMLINK

LNYLVFKDISITENGGLLKGYQLTYIPDKLKNVGHQCGCIFYVPAAYTSKIDPTT

GFVNIFKFKDLTVDAKREFIKKFDSIRYDSEKNLFCFTFDYNNFITQNTVMSKSS

WSVYTYGVRIKRRFVNGRFSNESDTIDITKDMEKTLEMTDINWRDGHDLRQDIID

YEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLISPVLNENNIFYDSAKAGDALPK

DADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISNKDWFDFIQNKRYL*

SEQ
MTNKFTNQYSLSKTLRFELIPQGKTLEFIQEKGLLSQDKQRAESYQEMKKTIDKF

ID
HKYFIDLALSNAKLTHLETYLELYNKSAETKKEQKFKDDLKKVQDNLRKEIVKSF

NO:
SDGDAKSIFAILDKKELITVELEKWFENNEQKDIYFDEKFKTFTTYFTGFHQNRK

8
NMYSVEPNSTAIAYRLIHENLPKFLENAKAFEKIKQVESLQVNFRELMGEFGDEG

LIFVNELEEMFQINYYNDVLSQNGITIYNSIISGFTKNDIKYKGLNEYINNYNQT

KDKKDRLPKLKQLYKQILSDRISLSFLPDAFTDGKQVLKAIFDFYKINLLSYTIE

GQEESQNLLLLIRQTIENLSSFDTQKIYLKNDTHLTTISQQVFGDFSVFSTALNY

WYETKVNPKFETEYSKANEKKREILDKAKAVFTKQDYFSIAFLQEVLSEYILTLD

HTSDIVKKHSSNCIADYFKNHFVAKKENETDKTFDFIANITAKYQCIQGILENAD

QYEDELKQDQKLIDNLKFFLDAILELLHFIKPLHLKSESITEKDTAFYDVFENYY

EALSLLTPLYNMVRNYVTQKPYSTEKIKLNFENAQLLNGWDANKEGDYLTTILKK

DGNYFLAIMDKKHNKAFQKFPEGKENYEKMVYKLLPGVNKMLPKVFFSNKNIAYF

NPSKELLENYKKETHKKGDTFNLEHCHTLIDFFKDSLNKHEDWKYFDFQFSETKS

YQDLSGFYREVEHQGYKINFKNIDSEYIDGLVNEGKLFLFQIYSKDFSPFSKGKP

NMHTLYWKALFEEQNLQNVIYKLNGQAEIFFRKASIKPKNIILHKKKIKIAKKHF

IDKKTKTSEIVPVQTIKNLNMYYQGKISEKELTQDDLRYIDNFSIFNEKNKTIDI

IKDKRFTVDKFQFHVPITMNFKATGGSYINQTVLEYLQNNPEVKIIGLDRGERHL

VYLTLIDQQGNILKQESLNTITDSKISTPYHKLLDNKENERDLARKNWGTVENIK

ELKEGYISQVVHKIATLMLEENAIVVMEDLNFGFKRGRFKVEKQIYQKLEKMLID

KLNYLVLKDKQPQELGGLYNALQLTNKFESFQKMGKQSGFLFYVPAWNTSKIDPT

TGFVNYFYTKYENVDKAKAFFEKFEAIRFNAEKKYFEFEVKKYSDENPKAEGTQQ

AWTICTYGERIETKRQKDQNNKFVSTPINLTEKIEDFLGKNQIVYGDGNCIKSQI

ASKDDKAFFETLLYWFKMTLQMRNSETRTDIDYLISPVMNDNGTFYNSRDYEKLE

NPTLPKDADANGAYHIAKKGLMLLNKIDQADLTKKVDLSISNRDWLQFVQKNK*

SEQ
MEQEYYLGLDMGTGSVGWAVTDSEYHVLRKHGKALWGVRLFESASTAEERRMFRT

ID
SRRRLDRRNWRIEILQEIFAEEISKKDPGFFLRMKESKYYPEDKRDINGNCPELP

NO:
YALFVDDDFTDKDYHKKFPTIYHLRKMLMNTEETPDIRLVYLAIHHMMKHRGHFL

9
LSGDINEIKEFGTTFSKLLENIKNEELDWNLELGKEEYAVVESILKDNMLNRSTK

KTRLIKALKAKSICEKAVLNLLAGGTVKLSDIFGLEELNETERPKISFADNGYDD

YIGEVENELGEQFYIIETAKAVYDWAVLVEILGKYTSISEAKVATYEKHKSDLQF

LKKIVRKYLTKEEYKDIFVSTSDKLKNYSAYIGMTKINGKKVDLQSKRCSKEEFY

DFIKKNVLKKLEGQPEYEYLKEELERETFLPKQVNRDNGVIPYQIHLYELKKILG

NLRDKIDLIKENEDKLVQLFEFRIPYYVGPLNKIDDGKEGKFTWAVRKSNEKIYP

WNFENVVDIEASAEKFIRRMTNKCTYLMGEDVLPKDSLLYSKYMVLNELNNVKLD

GEKLSVELKQRLYTDVFCKYRKVTVKKIKNYLKCEGIISGNVEITGIDGDFKASL

TAYHDFKEILTGTELAKKDKENIITNIVLFGDDKKLLKKRLNRLYPQITPNQLKK

ICALSYTGWGRFSKKFLEEITAPDPETGEVWNIITALWESNNNLMQLLSNEYRFM

EEVETYNMGKQTKTLSYETVENMYVSPSVKRQIWQTLKIVKELEKVMKESPKRVF

IEMAREKQESKRTESRKKQLIDLYKACKNEEKDWVKELGDQEEQKLRSDKLYLYY

TQKGRCMYSGEVIELKDLWDNTKYDIDHIYPQSKTMDDSLNNRVLVKKKYNATKS

DKYPLNENIRHERKGFWKSLLDGGFISKEKYERLIRNTELSPEELAGFIERQIVE

TRQSTKAVAEILKQVFPESEIVYVKAGTVSRFRKDFELLKVREVNDLHHAKDAYL

NIVVGNSYYVKFTKNASWFIKENPGRTYNLKKMFTSGWNIERNGEVAWEVGKKGT

IVTVKQIMNKNNILVTRQVHEAKGGLFDQQIMKKGKGQIAIKETDERLASIEKYG

GYNKAAGAYFMLVESKDKKGKTIRTIEFIPLYLKNKIESDESIALNFLEKGRGLK

EPKILLKKIKIDTLFDVDGFKMWLSGRTGDRLLFKCANQLILDEKIIVTMKKIVK

FIQRRQENRELKLSDKDGIDNEVLMEIYNTFVDKLENTVYRIRLSEQAKTLIDKQ

KEFERLSLEDKSSTLFEILHIFQCQSSAANLKMIGGPGKAGILVMNNNISKCNKI

SIINQSPTGIFENEIDLLK

SEQ
MNKFENFTGLYPISKTLRFELIPQGKTLEYIEKSEILENDNYRAEKYEEVKDIID

ID
GYHKWFINETLHDLHINWSELKVALENNRIEKSDASKKELQRVQKIKREEIYNAF

NO:
IEHEAFQYLFKENLLSDLLPIQIEQSEDLDAEKKKQAVETFNRFSTYFTGFHENR

10
KNIYSKEGISTSVTYRIVHDNFPKFLENMKVFEILRNECPEVISDTANELAPFID

GVRIEDIFLIDFFNSTFSQNGIDYYNRILGGVTTETGEKYRGINEFTNLYRQQHP

EFGKSKKATKMVVLFKQILSDRDTLSFIPEMFGNDKQVQNSIQLFYNREISQFEN

EGVKTDVCTALATLTSKIAEFDTEKIYIQQPELPNVSQRLFGSWNELNACLFKYA

ELKFGTAEKVANRKKIDKWLKSDLFSFTELNKALEFSGKDERIENYFSETGIFAQ

LVKTGFDEAQSILETEYTSEVHLKDQQTDIEKIKTFLDALQNLMHLLKSLCVSEE

ADRDAAFYNEFDMLYNQLKLVVPLYNKVRNYITQKLFRSDKIKIYFENKGQFLGG

WVDSQTENSDNGTQAGGYIFRKENVINEYDYYLGICSDPKLFRRTTIVSENDRSS

FERLDYYQLKTASVYGNSYCGKHPYTEDKNELVNSIDRFVHLSGNNILIEKIAKD

KVKSNPTTNTPSGYLNFIHREAPNTYECLLQDENFVSLNQRVVSALKATLATLVR

VPKALVYAKKDYHLFSEIINDIDELSYEKAFSYFPVSQTEFENSSNRTIKPLLLF

KISNKDLSFAENFEKGNRQKIGKKNLHTLYFEALMKGNQDTIDIGTGMVFHRVKS

LNYNEKTLKYGHHSTQLNEKFSYPIIKDKRFASDKFLFHLSTEINYKEKRKPLNN

SIIEFLTNNPDINIIGLDRGERHLIYLTLINQKGEILRQKTFNIVGNTNYHEKLN

QREKERDNARKSWATIGKIKELKEGFLSLVIHEIAKIMVENNAIVVLEDLNFGFK

RGRFKVEKQIYQKFEKMLIDKLNYLVFKDKKANEAGGVLKGYQLAEKFESFQKMG

KQSGFLFYVPAAYTSKIDPTTGFVNMLNLNYTNMKDAQTLLSGMDKISFNADANY

FEFELDYEKFKTNQTDHTNKWTICTVGEKRFTYNSATKETTTVNVTEDLKKLLDK

FEVKYSNGDNIKDEICRQTDAKFFEIILWLLKLTMQMRNSNTKTEEDFILSPVKN

SNGEFFRSNDDANGIWPADADANGAYHIALKGLYLVKECFNKNEKSLKIEHKNWF

KFAQTRENGSLTKNG*

SEQ
MENFKNLYPINKTLRFELRPYGKTLENFKKSGLLEKDAFKANSRRSMQAIIDEKF

ID
KETIEERLKYTEFSECDLGNMTSKDKKITDKAATNLKKQVILSFDDEIFNNYLKP

NO:
DKNIDALFKNDPSNPVISTFKGFTTYFVNFFEIRKHIFKGESSGSMAYRIIDENL

11
TTYLNNIEKIKKLPEELKSQLEGIDQIDKLNNYNEFITQSGITHYNEIIGGISKS

ENVKIQGINEGINLYCQKNKVKLPRLTPLYKMILSDRVSNSFVLDTIENDTELIE

MISDLINKTEISQDVIMSDIQNIFIKYKQLGNLPGISYSSIVNAICSDYDNNFGD

GKRKKSYENDRKKHLETNVYSINYISELLTDTDVSSNIKMRYKELEQNYQVCKEN

FNATNWMNIKNIKQSEKTNLIKDLLDILKSIQRFYDLFDIVDEDKNPSAEFYTWL

SKNAEKLDFEFNSVYNKSRNYLTRKQYSDKKIKLNFDSPTLAKGWDANKEIDNST

IIMRKENNDRGDYDYFLGIWNKSTPANEKIIPLEDNGLFEKMQYKLYPDPSKMLP

KQFLSKIWKAKHPTTPEFDKKYKEGRHKKGPDFEKEFLHELIDCFKHGLVNHDEK

YQDVFGFNLRNTEDYNSYTEFLEDVERCNYNLSENKIADTSNLINDGKLYVFQIW

SKDFSIDSKGTKNLNTIYFESLFSEENMIEKMFKLSGEAEIFYRPASLNYCEDII

KKGHHHAELKDKFDYPIIKDKRYSQDKFFFHVPMVINYKSEKLNSKSLNNRTNEN

LGQFTHIIGIDRGERHLIYLTVVDVSTGEIVEQKHLDEIINTDTKGVEHKTHYLN

KLEEKSKTRDNERKSWEAIETIKELKEGYISHVINEIQKLQEKYNALIVMENLNY

GFKNSRIKVEKQVYQKFETALIKKFNYIIDKKDPETYIHGYQLTNPITTLDKIGN

QSGIVLYIPAWNTSKIDPVTGFVNLLYADDLKYKNQEQAKSFIQKIDNIYFENGE

FKFDIDFSKWNNRYSISKTKWTLTSYGTRIQTFRNPQKNNKWDSAEYDLTEEFKL

ILNIDGTLKSQDVETYKKFMSLFKLMLQLRNSVTGTDIDYMISPVTDKTGTHFDS

RENIKNLPADADANGAYNIARKGIMAIENIMNGISDPLKISNEDYLKYIQNQQE

SEQ
MTQFEGFTNLYQVSKTLRFELIPQGKTLKHIQEQGFIEEDKARNDHYKELKPIID

ID
RIYKTYADQCLQLVQLDWENLSAAIDSYRKEKTEETRNALIEEQATYRNAIHDYF

NO:
IGRTDNLTDAINKRHAEIYKGLFKAELFNGKVLKQLGTVTTTEHENALLRSFDKF

12
TTYFSGFYENRKNVFSAEDISTAIPHRIVQDNFPKFKENCHIFTRLITAVPSLRE

HFENVKKAIGIFVSTSIEEVFSFPFYNQLLTQTQIDLYNQLLGGISREAGTEKIK

GLNEVLNLAIQKNDETAHIIASLPHRFIPLFKQILSDRNTLSFILEEFKSDEEVI

QSFCKYKTLLRNENVLETAEALFNELNSIDLTHIFISHKKLETISSALCDHWDTL

RNALYERRISELTGKITKSAKEKVQRSLKHEDINLQEIISAAGKELSEAFKQKTS

EILSHAHAALDQPLPTTLKKQEEKEILKSQLDSLLGLYHLLDWFAVDESNEVDPE

FSARLTGIKLEMEPSLSFYNKARNYATKKPYSVEKFKLNFQMPTLASGWDVNKEK

NNGAILFVKNGLYYLGIMPKQKGRYKALSFEPTEKTSEGFDKMYYDYFPDAAKMI

PKCSTQLKAVTAHFQTHTTPILLSNNFIEPLEITKEIYDLNNPEKEPKKFQTAYA

KKTGDQKGYREALCKWIDFTRDFLSKYTKTTSIDLSSLRPSSQYKDLGEYYAELN

PLLYHISFQRIAEKEIMDAVETGKLYLFQIYNKDFAKGHHGKPNLHTLYWTGLFS

PENLAKTSIKLNGQAELFYRPKSRMKRMAHRLGEKMLNKKLKDQKTPIPDTLYQE

LYDYVNHRLSHDLSDEARALLPNVITKEVSHEIIKDRRFTSDKFFFHVPITLNYQ

AANSPSKFNQRVNAYLKEHPETPIIGIDRGERNLIYITVIDSTGKILEQRSLNTI

QQFDYQKKLDNREKERVAARQAWSVVGTIKDLKQGYLSQVIHEIVDLMIHYQAVV

VLENLNFGFKSKRTGIAEKAVYQQFEKMLIDKLNCLVLKDYPAEKVGGVLNPYQL

TDQFTSFAKMGTQSGFLFYVPAPYTSKIDPLTGFVDPFVWKTIKNHESRKHFLEG

FDFLHYDVKTGDFILHFKMNRNLSFQRGLPGFMPAWDIVFEKNETQFDAKGTPFI

AGKRIVPVIENHRFTGRYRDLYPANELIALLEEKGIVFRDGSNILPKLLENDDSH

AIDTMVALIRSVLQMRNSNAATGEDYINSPVRDLNGVCFDSRFQNPEWPMDADAN

GAYHIALKGQLLLNHLKESKDLKLQNGISNQDWLAYIQELRN*

SEQ
MAVKSIKVKLRLDDMPEIRAGLWKLHKEVNAGVRYYTEWLSLLRQENLYRRSPNG

ID
DGEQECDKTAEECKAELLERLRARQVENGHRGPAGSDDELLQLARQLYELLVPQA

NO:
IGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWVRMREAGEPGWEEEKEK

13
AETRKSADRTADVLRALADFGLKPLMRVYTDSEMSSVEWKPLRKGQAVRTWDRDM

FQQAIERMMSWESWNQRVGQEYAKLVEQKNRFEQKNFVGQEHLVHLVNQLQQDMK

EASPGLESKEQTAHYVTGRALRGSDKVFEKWGKLAPDAPFDLYDAEIKNVQRRNT

RRFGSHDLFAKLAEPEYQALWREDASFLTRYAVYNSILRKLNHAKMFATFTLPDA

TAHPIWTRFDKLGGNLHQYTFLFNEFGERRHAIRFHKLLKVENGVAREVDDVTVP

ISMSEQLDNLLPRDPNEPIALYFRDYGAEQHFTGEFGGAKIQCRRDQLAHMHRRR

GARDVYLNVSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDKLSDYLAEHP

DDGKLGSEGLLSGLRVMSVDLGLRTSASISVFRVARKDELKPNSKGRVPFFFPIK

GNDNLVAVHERSQLLKLPGETESKDLRAIREERQRTLRQLRTQLAYLRLLVRCGS

EDVGRRERSWAKLIEQPVDAANHMTPDWREAFENELQKLKSLHGICSDKEWMDAV

YESVRRVWRHMGKQVRDWRKDVRSGERPKIRGYAKDVVGGNSIEQIEYLERQYKF

LKSWSFFGKVSGQVIRAEKGSRFAITLREHIDHAKEDRLKKLADRIIMEALGYVY

ALDERGKGKWVAKYPPCQLILLEELSEYQFNNDRPPSENNQLMQWSHRGVFQELI

NQAQVHDLLVGTMYAAFSSRFDARTGAPGIRCRRVPARCTQEHNPEPFPWWLNKF

VVEHTLDACPLRADDLIPTGEGEIFVSPFSAEEGDFHQIHADLNAAQNLQQRLWS

DFDISQIRLRCDWGEVDGELVLIPRLTGKRTADSYSNKVFYTNTGVTYYERERGK

KRRKVFAQEKLSEEEAELLVEADEAREKSVVLMRDPSGIINRGNWTRQKEFWSMV

NQRIEGYLVKQIRSRVPLQDSACENTGDI*

SEQ
MATRSFILKIEPNEEVKKGLWKTHEVLNHGIAYYMNILKLIRQEAIYEHHEQDPK

ID
NPKKVSKAEIQAELWDFVLKMQKCNSFTHEVDKDVVFNILRELYEELVPSSVEKK

NO:
GEANQLSNKFLYPLVDPNSQSGKGTASSGRKPRWYNLKIAGDPSWEEEKKKWEED

14
KKKDPLAKILGKLAEYGLIPLFIPFTDSNEPIVKEIKWMEKSRNQSVRRLDKDMF

IQALERFLSWESWNLKVKEEYEKVEKEHKTLEERIKEDIQAFKSLEQYEKERQEQ

LLRDTLNTNEYRLSKRGLRGWREIIQKWLKMDENEPSEKYLEVFKDYQRKHPREA

GDYSVYEFLSKKENHFIWRNHPEYPYLYATFCEIDKKKKDAKQQATFTLADPINH

PLWVRFEERSGSNLNKYRILTEQLHTEKLKKKLTVQLDRLIYPTESGGWEEKGKV

DIVLLPSRQFYNQIFLDIEEKGKHAFTYKDESIKFPLKGTLGGARVQFDRDHLRR

YPHKVESGNVGRIYFNMTVNIEPTESPVSKSLKIHRDDFPKFVNFKPKELTEWIK

DSKGKKLKSGIESLEIGLRVMSIDLGQRQAAAASIFEVVDQKPDIEGKLFFPIKG

TELYAVHRASFNIKLPGETLVKSREVLRKAREDNLKLMNQKLNFLRNVLHFQQFE

DITEREKRVTKWISRQENSDVPLVYQDELIQIRELMYKPYKDWVAFLKQLHKRLE

VEIGKEVKHWRKSLSDGRKGLYGISLKNIDEIDRTRKFLLRWSLRPTEPGEVRRL

EPGQRFAIDQLNHLNALKEDRLKKMANTIIMHALGYCYDVRKKKWQAKNPACQII

LFEDLSNYNPYEERSRFENSKLMKWSRREIPRQVALQGEIYGLQVGEVGAQFSSR

FHAKTGSPGIRCSVVTKEKLQDNRFFKNLQREGRLTLDKIAVLKEGDLYPDKGGE

KFISLSKDRKLVTTHADINAAQNLQKRFWTRTHGFYKVYCKAYQVDGQTVYIPES

KDQKQKIIEEFGEGYFILKDGVYEWGNAGKLKIKKGSSKQSSSELVDSDILKDSF

DLASELKGEKLMLYRDPSGNVFPSDKWMAAGVFFGKLERILISKLTNQYSISTIE

DDSSKQSM*

SEQ
MPTRTINLKLVLGKNPENATLRRALFSTHRLVNQATKRIEEFLLLCRGEAYRTVD

ID
NEGKEAEIPRHAVQEEALAFAKAAQRHNGCISTYEDQEILDVLRQLYERLVPSVN

NO:
ENNEAGDAQAANAWVSPLMSAESEGGLSVYDKVLDPPPVWMKLKEEKAPGWEAAS

15
QIWIQSDEGQSLLNKPGSPPRWIRKLRSGQPWQDDFVSDQKKKQDELTKGNAPLI

KQLKEMGLLPLVNPFFRHLLDPEGKGVSPWDRLAVRAAVAHFISWESWNHRTRAE

YNSLKLRRDEFEAASDEFKDDFTLLRQYEAKRHSTLKSIALADDSNPYRIGVRSL

RAWNRVREEWIDKGATEEQRVTILSKLQTQLRGKFGDPDLFNWLAQDRHVHLWSP

RDSVTPLVRINAVDKVLRRRKPYALMTFAHPRFHPRWILYEAPGGSNLRQYALDC

TENALHITLPLLVDDAHGTWIEKKIRVPLAPSGQIQDLTLEKLEKKKNRLYYRSG

FQQFAGLAGGAEVLFHRPYMEHDERSEESLLERPGAVWFKLTLDVATQAPPNWLD

GKGRVRTPPEVHHFKTALSNKSKHTRTLQPGLRVLSVDLGMRTFASCSVFELIEG

KPETGRAFPVADERSMDSPNKLWAKHERSFKLTLPGETPSRKEEEERSIARAEIY

ALKRDIQRLKSLLRLGEEDNDNRRDALLEQFFKGWGEEDVVPGQAFPRSLFQGLG

AAPFRSTPELWRQHCQTYYDKAEACLAKHISDWRKRTRPRPTSREMWYKTRSYHG

GKSIWMLEYLDAVRKLLLSWSLRGRTYGAINRQDTARFGSLASRLLHHINSLKED

RIKTGADSIVQAARGYIPLPHGKGWEQRYEPCQLILFEDLARYRFRVDRPRRENS

QLMQWNHRAIVAETTMQAELYGQIVENTAAGFSSRFHAATGAPGVRCRFLLERDF

DNDLPKPYLLRELSWMLGNTKVESEEEKLRLLSEKIRPGSLVPWDGGEQFATLHP

KRQTLCVIHADMNAAQNLQRRFFGRCGEAFRLVCQPHGDDVLRLASTPGARLLGA

LQQLENGQGAFELVRDMGSTSQMNRFVMKSLGKKKIKPLQDNNGDDELEDVLSVL

PEEDDTGRITVFRDSSGIFFPCNVWIPAKQFWPAVRAMIWKVMASHSLG*

SEQ
MTKLRHRQKKLTHDWAGSKKREVLGSNGKLQNPLLMPVKKGQVTEFRKAFSAYAR

ID
ATKGEMTDGRKNMFTHSFEPFKTKPSLHQCELADKAYQSLHSYLPGSLAHFLLSA

NO:
HALGFRIFSKSGEATAFQASSKIEAYESKLASELACVDLSIQNLTISTLFNALTT

16
SVRGKGEETSADPLIARFYTLLTGKPLSRDTQGPERDLAEVISRKIASSFGTWKE

MTANPLQSLQFFEEELHALDANVSLSPAFDVLIKMNDLQGDLKNRTIVFDPDAPV

FEYNAEDPADIIIKLTARYAKEAVIKNQNVGNYVKNAITTTNANGLGWLLNKGLS

LLPVSTDDELLEFIGVERSHPSCHALIELIAQLEAPELFEKNVFSDTRSEVQGMI

DSAVSNHIARLSSSRNSLSMDSEELERLIKSFQIHTPHCSLFIGAQSLSQQLESL

PEALQSGVNSADILLGSTQYMLTNSLVEESIATYQRTLNRINYLSGVAGQINGAI

KRKAIDGEKIHLPAAWSELISLPFIGQPVIDVESDLAHLKNQYQTLSNEFDTLIS

ALQKNFDLNFNKALLNRTQHFEAMCRSTKKNALSKPEIVSYRDLLARLTSCLYRG

SLVLRRAGIEVLKKHKIFESNSELREHVHERKHFVFVSPLDRKAKKLLRLTDSRP

DLLHVIDEILQHDNLENKDRESLWLVRSGYLLAGLPDQLSSSFINLPIITQKGDR

RLIDLIQYDQINRDAFVMLVTSAFKSNLSGLQYRANKQSFVVTRTLSPYLGSKLV

YVPKDKDWLVPSQMFEGRFADILQSDYMVWKDAGRLCVIDTAKHLSNIKKSVFSS

EEVLAFLRELPHRTFIQTEVRGLGVNVDGIAFNNGDIPSLKTFSNCVQVKVSRTN

TSLVQTLNRWFEGGKVSPPSIQFERAYYKKDDQIHEDAAKRKIRFQMPATELVHA

SDDAGWTPSYLLGIDPGEYGMGLSLVSINNGEVLDSGFIHINSLINFASKKSNHQ

TKVVPRQQYKSPYANYLEQSKDSAAGDIAHILDRLIYKLNALPVFEALSGNSQSA

ADQVWTKVLSFYTWGDNDAQNSIRKQHWFGASHWDIKGMLRQPPTEKKPKPYIAF

PGSQVSSYGNSQRCSCCGRNPIEQLREMAKDTSIKELKIRNSEIQLFDGTIKLFN

PDPSTVIERRRHNLGPSRIPVADRTFKNISPSSLEFKELITIVSRSIRHSPEFIA

KKRGIGSEYFCAYSDCNSSLNSEANAAANVAQKFQKQLFFEL*

SEQ
MKRILNSLKVAALRLLFRGKGSELVKTVKYPLVSPVQGAVEELAEAIRHDNLHLF

ID
GQKEIVDLMEKDEGTQVYSVVDFWLDTLRLGMFFSPSANALKITLGKFNSDQVSP

NO:
FRKVLEQSPFFLAGRLKVEPAERILSVEIRKIGKRENRVENYAADVETCFIGQLS

17
SDEKQSIQKLANDIWDSKDHEEQRMLKADFFAIPLIKDPKAVTEEDPENETAGKQ

KPLELCVCLVPELYTRGFGSIADFLVQRLTLLRDKMSTDTAEDCLEYVGIEEEKG

NGMNSLLGTFLKNLQGDGFEQIFQFMLGSYVGWQGKEDVLRERLDLLAEKVKRLP

KPKFAGEWSGHRMFLHGQLKSWSSNFFRLFNETRELLESIKSDIQHATMLISYVE

EKGGYHPQLLSQYRKLMEQLPALRTKVLDPEIEMTHMSEAVRSYIMIHKSVAGFL

PDLLESLDRDKDREFLLSIFPRIPKIDKKTKEIVAWELPGEPEEGYLFTANNLFR

NFLENPKHVPRFMAERIPEDWTRLRSAPVWFDGMVKQWQKVVNQLVESPGALYQF

NESFLRQRLQAMLTVYKRDLQTEKFLKLLADVCRPLVDFFGLGGNDIIFKSCQDP

RKQWQTVIPLSVPADVYTACEGLAIRLRETLGFEWKNLKGHEREDFLRLHQLLGN

LLFWIRDAKLVVKLEDWMNNPCVQEYVEARKAIDLPLEIFGFEVPIFLNGYLFSE

LRQLELLLRRKSVMTSYSVKTTGSPNRLFQLVYLPLNPSDPEKKNSNNFQERLDT

PTGLSRRFLDLTLDAFAGKLLTDPVTQELKTMAGFYDHLFGFKLPCKLAAMSNHP

GSSSKMVVLAKPKKGVASNIGFEPIPDPAHPVFRVRSSWPELKYLEGLLYLPEDT

PLTIELAETSVSCQSVSSVAFDLKNLTTILGRVGEFRVTADQPFKLTPIIPEKEE

SFIGKTYLGLDAGERSGVGFAIVTVDGDGYEVQRLGVHEDTQLMALQQVASKSLK

EPVFQPLRKGTFRQQERIRKSLRGCYWNFYHALMIKYRAKVVHEESVGSSGLVGQ

WLRAFQKDLKKADVLPKKGGKNGVDKKKRESSAQDTLWGGAFSKKEEQQIAFEVQ

AAGSSQFCLKCGWWFQLGMREVNRVQESGVVLDWNRSIVTFLIESSGEKVYGFSP

QQLEKGFRPDIETFKKMVRDFMRPPMFDRKGRPAAAYERFVLGRRHRRYRFDKVF

EERFGRSALFICPRVGCGNFDHSSEQSAVVLALIGYIADKEGMSGKKLVYVRLAE

LMAEWKLKKLERSRVEEQSSAQ*

SEQ
MAESKQMQCRKCGASMKYEVIGLGKKSCRYMCPDCGNHTSARKIQNKKKRDKKYG

ID
SASKAQSQRIAVAGALYPDKKVQTIKTYKYPADLNGEVHDSGVAEKIAQAIQEDE

NO:
IGLLGPSSEYACWIASQKQSEPYSVVDFWFDAVCAGGVFAYSGARLLSTVLQLSG

18
EESVLRAALASSPFVDDINLAQAEKFLAVSRRTGQDKLGKRIGECFAEGRLEALG

IKDRMREFVQAIDVAQTAGQRFAAKLKIFGISQMPEAKQWNNDSGLTVCILPDYY

VPEENRADQLVVLLRRLREIAYCMGIEDEAGFEHLGIDPGALSNFSNGNPKRGFL

GRLLNNDIIALANNMSAMTPYWEGRKGELIERLAWLKHRAEGLYLKEPHFGNSWA

DHRSRIFSRIAGWLSGCAGKLKIAKDQISGVRTDLFLLKRLLDAVPQSAPSPDFI

ASISALDRFLEAAESSQDPAEQVRALYAFHLNAPAVRSIANKAVQRSDSQEWLIK

ELDAVDHLEFNKAFPFFSDTGKKKKKGANSNGAPSEEEYTETESIQQPEDAEQEV

NGQEGNGASKNQKKFQRIPRFFGEGSRSEYRILTEAPQYFDMFCNNMRAIFMQLE

SQPRKAPRDFKCFLQNRLQKLYKQTFLNARSNKCRALLESVLISWGEFYTYGANE

KKFRLRHEASERSSDPDYVVQQALEIARRLFLFGFEWRDCSAGERVDLVEIHKKA

ISFLLAITQAEVSVGSYNWLGNSTVSRYLSVAGTDTLYGTQLEEFLNATVLSQMR

GLAIRLSSQELKDGFDVQLESSCQDNLQHLLVYRASRDLAACKRATCPAELDPKI

LVLPVGAFIASVMKMIERGDEPLAGAYLRHRPHSFGWQIRVRGVAEVGMDQGTAL

AFQKPTESEPFKIKPFSAQYGPVLWLNSSSYSQSQYLDGFLSQPKNWSMRVLPQA

GSVRVEQRVALIWNLQAGKMRLERSGARAFFMPVPFSFRPSGSGDEAVLAPNRYL

GLFPHSGGIEYAVVDVLDSAGFKILERGTIAVNGFSQKRGERQEEAHREKQRRGI

SDIGRKKPVQAEVDAANELHRKYTDVATRLGCRIVVQWAPQPKPGTAPTAQTVYA

RAVRTEAPRSGNQEDHARMKSSWGYTWGTYWEKRKPEDILGISTQVYWTGGIGES

CPAVAVALLGHIRATSTQTEWEKEEVVFGRLKKFFPS*

SEQ
MEKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQ

ID
VISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNK

NO:
LKPEMDEKGNLTTAGFACSQCGQPLFVYKLEQVSEKGKAYTNYFGRCNVAEHEKL

19
ILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYA

SGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRELAGKENLEY

PSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLKLSRDDAKPLLRLKGFPS

FPVVERRENEVDWWNTINEVKKLIDAKRDMGRVFWSGVTAEKRNTILEGYNYLPN

ENDHKKREGSLENPKKPAKRQFGDLLLYLEKKYAGDWGKVFDEAWERIDKKIAGL

TSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWY

GDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNY

GKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQ

GREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDP

SNIKPVNLIGVDRGENIPAVIALTDPEGCPLPEFKDSSGGPTDILRIGEGYKEKQ

RAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFEN

LSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSN

CGFTITTADYDGMLVRLKKTSDGWATTLNNKELKAEGQITYYNRYKRQTVEKELS

AELDRLSEESGNNDISKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAD

EQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWKPNA

SEQ
MKRINKIRRRLVKDSNTKKAGKTGPMKTLLVRVMTPDLRERLENLRKKPENIPQP

ID
ISNTSRANLNKLLTDYTEMKKAILHVYWEEFQKDPVGLMSRVAQPAPKNIDQRKL

NO:
IPVKDGNERLTSSGFACSQCCQPLYVYKLEQVNDKGKPHTNYFGRCNVSEHERLI

20
LLSPHKPEANDELVTYSLGKFGQRALDFYSIHVTRESNHPVKPLEQIGGNSCASG

PVGKALSDACMGAVASFLTKYQDIILEHQKVIKKNEKRLANLKDIASANGLAFPK

ITLPPQPHTKEGIEAYNNVVAQIVIWVNLNLWQKLKIGRDEAKPLQRLKGFPSFP

LVERQANEVDWWDMVCNVKKLINEKKEDGKVFWQNLAGYKRQEALLPYLSSEEDR

KKGKKFARYQFGDLLLHLEKKHGEDWGKVYDEAWERIDKKVEGLSKHIKLEEERR

SEDAQSKAALTDWLRAKASFVIEGLKEADKDEFCRCELKLQKWYGDLRGKPFAIE

AENSILDISGFSKQYNCAFIWQKDGVKKLNLYLIINYFKGGKLRFKKIKPEAFEA

NRFYTVINKKSGEIVPMEVNFNFDDPNLIILPLAFGKRQGREFIWNDLLSLETGS

LKLANGRVIEKTLYNRRTRQDEPALFVALTFERREVLDSSNIKPMNLIGIDRGEN

IPAVIALTDPEGCPLSRFKDSLGNPTHILRIGESYKEKQRTIQAAKEVEQRRAGG

YSRKYASKAKNLADDMVRNTARDLLYYAVTQDAMLIFENLSRGFGRQGKRTFMAE

RQYTRMEDWLTAKLAYEGLPSKTYLSKTLAQYTSKTCSNCGFTITSADYDRVLEK

LKKTATGWMTTINGKELKVEGQITYYNRYKRQNVVKDLSVELDRLSEESVNNDIS

SWTKGRSGEALSLLKKRFSHRPVQEKFVCLNCGFETHADEQAALNIARSWLFLRS

QEYKKYQTNKTTGNTDKRAFVETWQSFYRKKLKEVWKP

SEQ
atgGGAAAAATGTATTATCTTGGTCTGGATATAGGAACAAATTCTGTTGGATATG

ID
CCGTAACCGACCCATCGTACCATTTGCTCAAATTTAAAGGCGAACCGATGTGGGG

NO:
TGCCCACGTGTTTGCTGCGGGGAATCAATCAGCTGAACGGAGAAGCTTTCGTACG

21
AGCCGCAGACGCCTTGACCGCAGGCAACAGCGTGTCAAACTGGTTCAAGAAATCT

TTGCTCCCGTGATTAGTCCCATTGATCCACGTTTTTTTATCAGACTTCATGAGAG

CGCTTTATGGCGGGATGATGTGGCTGAAACGGATAAACATATTTTCTTTAATGAC

CCGACCTATACGGATAAGGAATATTATTCTGACTATCCAACCATCCATCATCTCA

TTGTGGACCTTATGGAAAGCAGTGAAAAGCATGACCCGCGGCTTGTTTATTTGGC

TGTTGCCTGGCTGGTTGCTCATCGTGGTCATTTCCTCAATGAAGTGGATAAGGAT

AATATTGGGGATGTCCTGAGTTTTGACGCCTTTTATCCTGAGTTTCTGGCATTTC

TTTCCGATAATGGGGTGTCACCTTGGGTATGTGAGTCAAAAGCACTCCAAGCGAC

CCTGCTTTCACGAAACTCCGTCAACGATAAGTATAAAGCCTTGAAGTCTCTGATC

TTTGGCAGCCAAAAGCCGGAGGATAATTTTGATGCCAATATCAGTGAAGATGGAC

TTATCCAACTTTTAGCAGGAAAAAAGGTCAAGGTCAATAAACTTTTTCCTCAAGA

AAGTAATGATGCTTCCTTTACACTCAATGATAAGGAAGATGCAATTGAGGAAATC

TTAGGAACGCTTACACCGGATGAGTGTGAATGGATTGCGCATATTAGGAGGCTGT

TTGATTGGGCCATCATGAAACATGCTCTCAAAGATGGCAGAACAATCTCCGAATC

GAAAGTAAAGCTCTATGAACAGCATCACCATGACTTGACACAGCTCAAGTATTTT

GTGAAGACCTATCTAGCAAAGGAATATGATGACATTTTTCGAAACGTAGATAGTG

AAACAACCAAAAACTATGTCGCATATTCCTATCATGTAAAAGAAGTCAAGGGTAC

ATTGCCCAAAAATAAGGCAACCCAAGAAGAATTTTGCAAGTATGTCCTTGGAAAG

GTAAAGAACATCGAATGCAGTGAAGCTGATAAGGTTGATTTTGATGAAATGATTC

AGCGTCTTACAGACAATTCCTTTATGCCGAAACAAGTATCAGGTGAAAACAGGGT

TATCCCTTACCAGCTTTACTATTATGAACTAAAGACTATTTTGAATAAAGCCGCT

TCTTATCTGCCTTTTTTGACCCAATGCGGAAAAGATGCCATCTCCAATCAAGATA

AGCTCCTTTCCATCATGACCTTTCGGATTCCGTATTTCGTTGGGCCCTTGCGCAA

GGACAATTCAGAGCATGCCTGGCTGGAACGAAAAGCAGGGAAAATCTATCCGTGG

AATTTTAACGACAAAGTTGACCTTGATAAAAGTGAAGAAGCGTTCATTCGGAGAA

TGACGAATACCTGCACTTATTATCCCGGTGAAGATGTTTTGCCACTTGACTCCCT

TATTTATGAAAAATTCATGATCCTCAATGAAATCAATAATATCCGAATTGATGGT

TATCCTATTTCTGTAGATGTAAAACAGCAGGTTTTTGGCCTCTTTGAAAAGAAGA

GAAGAGTGACCGTAAAGGATATCCAGAATCTCCTGCTTTCCTTGGGTGCCTTGGA

TAAGCATGGTAAATTGACGGGAATCGATACTACCATCCATAGCAATTACAATACA

TACCATCATTTTAAATCGCTCATGGAGCGTGGCGTTCTTACTCGTGATGATGTGG

AACGCATTGTGGAGCGTATGACCTATAGTGATGATACAAAACGCGTCCGTCTTTG

GCTGAACAATAATTATGGAACGCTCACTGCTGACGACGTAAAGCATATTTCAAGG

CTCCGAAAGCATGATTTTGGCCGGCTTTCCAAAATGTTCCTCACAGGCCTAAAGG

GAGTTCATAAGGAAACGGGGGAACGAGCTTCCATTTTGGATTTTATGTGGAATAC

CAATGATAACTTGATGCAGCTTTTATCTGAATGTTATACTTTTTCGGATGAAATT

ACCAAGCTGCAGGAAGCATACTATGCCAAGGCGCAGCTTTCCCTGAATGATTTTC

TGGACTCCATGTATATTTCAAATGCTGTCAAACGTCCTATCTATCGAACTCTTGC

CGTTGTAAATGACATACGCAAAGCCTGTGGGACGGCGCCAAAACGCATTTTTATC

GAAATGGCAAGAGATGGGGAAAGCAAAAAGAAAAGGAGCGTAACAAGAAGAGAAC

AAATCAAGAATCTTTATAGGTCCATCCGCAAGGATTTTCAGCAGGAGGTAGATTT

CCTTGAAAAAATCCTTGAAAACAAAAGCGATGGACAGCTGCAAAGCGATGCGCTC

TATCTATACTTTGCGCAGCTTGGAAGGGATATGTATACCGGGGACCCTATCAAGT

TGGAGCATATCAAGGACCAGTCCTTCTATAATATTGATCATATCTATCCCCAAAG

CATGGTCAAGGACGATAGTCTTGATAACAAGGTGTTGGTTCAATCGGAAATTAAT

GGAGAGAAGAGCAGTCGATATCCTCTTGATGCTGCTATCCGTAATAAAATGAAGC

CTCTTTGGGATGCTTATTATAACCATGGCCTGATTTCCCTCAAGAAGTATCAGCG

TTTGACGCGGAGCACTCCCTTTACAGATGATGAAAAGTGGGATTTCATCAATCGG

CAGCTTGTTGAGACAAGACAATCCACGAAGGCCTTGGCAATCTTACTAAAAAGGA

AGTTCCCTGATACGGAGATTGTCTACTCCAAGGCAGGGCTTTCTTCTGATTTTCG

GCATGAGTTTGGTCTCGTAAAATCGAGGAATATCAATGACCTGCACCATGCAAAG

GACGCATTTCTTGCGATTGTAACAGGAAATGTCTATCATGAACGCTTTAATCGCC

GGTGGTTTATGGTGAACCAGCCCTATTCCGTCAAGACCAAGACGTTGTTTACGCA

TTCTATTAAAAATGGTAATTTTGTAGCTTGGAATGGAGAAGAGGATCTTGGCCGC

ATTGTTAAAATGTTAAAGCAAAATAAGAACACTATTCATTTCACGCGGTTCTCTT

TTGATCGAAAGGAAGGCCTGTTTGATATTCAGCCACTAAAAGCGTCAACCGGTCT

TGTACCAAGAAAAGCCGGACTAGACGTGGTAAAATATGGTGGCTATGACAAATCG

ACAGCAGCTTATTATCTCCTTGTTCGATTTACACTAGAAGATAAAAAGACTCAAC

ATAAATTGATGATGATTCCTGTAGAAGGCTTGTATAAAGCTCGAATTGACCATGA

TAAGGAATTCTTAACGGACTATGCACAAACTACAATCAGTGAAATCCTACAAAAA

GATAAACAAAAGGTGATAAATATAATGTTTCCAATGGGAACAAGGCACATTAAAC

TGAATTCCATGATTTCAATCGATGGTTTTTATCTTTCCATTGGAGGAAAGTCTAG

TAAGGGAAAATCGGTGTTGTGTCATGCTATGGTACCTCTTATTGTACCTCATAAG

ATAGAATGTTATATTAAGGCGATGGAGTCTTTTGCACGTAAATTTAAAGAAAATA

ATAAATTAAGGATTGTGGAAAAGTTTGATAAGATTACGGTGGAAGATAACTTGAA

CCTATACGAACTATTTTTACAAAAACTTCAACATAACCCATATAATAAGTTCTTC

TCCACACAATTTGATGTGCTGACTAATGGAAGAAGTACATTTACTAAATTATCTC

CAGAGGAACAAGTTCAAACGTTATTGAATATCTTATCAATTTTTAAAACTTGTCG

GAGCTCTGGCTGCGATTTAAAATCCATTAACGGTTCTGCTCAAGCTGCCAGAATT

ATGATCAGCGCAGATTTAACTGGACTCTCAAAAAAATATTCCGATATTCGGCTTG

TTGAGCAATCAGCATCTGGACTTTTTGTTAGTAAATCACAAAATCTTTTGGAGTA

TTTAtga

SEQ
atgtcttcattaacaaaatttacaaataaatacagtaagcagctaaccataaaaa

ID
atgaactcatcccagtaggaaagactctcgagaacattaaggaaaacggtctcat

NO:
agatggagatgaacagctaaacgagaattatcaaaaagcaaagataatcgttgat

22
gattttctacgagatttcataaataaagctttaaataatacccaaataggaaatt

ggagagaattagcagatgctttaaataaagaagatgaagataacatagaaaagct

ccaagacaaaatcagaggaataattgtaagtaaattcgagacatttgatttgttt

tcttcttactcgataaagaaagacgaaaagataatagatgatgataatgatgttg

aagaagaggagctagatctaggaaaaaaaacttcctcatttaaatatatttttaa

gaaaaacctttttaaattagtacttccttcttatttaaagacaacaaatcaggat

aaactgaaaataatctcttcttttgataatttttctacctatttcagaggattct

ttgagaacagaaaaaatattttcactaagaagcctatatctacgtcaattgccta

cagaattgtccatgataactttccaaagtttctagataacatcagatgttttaat

gtgtggcaaacagaatgcccacagttaattgtaaaggctgataattatttaaaat

caaagaacgtcatagctaaagataaatctttagcaaactattttactgtaggagc

atatgattacttcttatcccagaatggcattgatttctacaacaacattatcggc

ggtctaccagcatttgctggtcatgagaaaatccaaggacttaatgaatttataa

atcaagaatgccaaaaggacagcgaactaaaatctaaactgaaaaacagacatgc

tttcaaaatggctgttctatttaagcaaattctttcagatagagaaaaaagtttt

gttatagacgagttcgaatctgatgctcaggtcatagatgcggttaagaacttct

atgcagaacaatgtaaggataataatgttatttttaaccttctaaatcttatcaa

gaatatagcgttcttatctgatgatgaattagatggaatttttatagaaggcaag

tatttaagctctgtttcccaaaagctatattcagattggtcgaagcttcgaaatg

atattgaagatagtgcaaacagtaaacaaggaaataaagagttagcaaagaaaat

taaaacaaataaaggcgatgttgaaaaggccataagtaaatatgagttttcttta

tcagaacttaactcaattgtacatgataatacaaaattcagtgaccttctttctt

gtacgttacataaagtggctagcgaaaaactagtgaaagttaatgaaggggactg

gccaaaacacctgaaaaataatgaagaaaaacaaaagataaaagagcctttagat

gcattgttagaaatttataatacattgctgatattcaactgcaagtcatttaata

agaacggtaatttctatgttgattatgacagatgcataaatgagctttctagtgt

tgtttatttatataacaaaacaagaaattactgtacaaagaaaccttataacaca

gacaaattcaaattaaactttaacagtcctcaattaggagagggctttagtaagt

cgaaagaaaatgactgtctgacattattatttaaaaaagacgacaattactatgt

tggaattatcagaaaaggggcaaaaattaactttgatgatacacaagccattgca

gacaatacagataactgtatatttaagatgaattatttcctattaaaagatgcta

aaaagtttattcctaaatgttcaattcagttaaaagaagtaaaagcacattttaa

aaaatcagaggatgattatatcctgagtgacaaagaaaaatttgcctctcccctt

gttattaagaaatcaacatttttattagcaacagcacatgtaaaaggaaagaaag

gaaacataaaaaaattccaaaaggaatattctaaggaaaatccaacagaatatag

aaattctctgaatgaatggattgcattttgtaaagaatttctaaaaacatataag

gcggcaacaatctttgacattacaacgttaaaaaaagctgaagaatatgctgata

ttgttgagttttataaggatgtagataatctttgttataaactagagttttgccc

tattaaaacatctttcattgagaatcttattgataatggggacttatatttattc

agaatcaataataaagatttcagttcaaaatctactggtacaaagaatcttcata

cgctctatcttcaggcaatctttgatgaaagaaacctcaataatcctactattat

gttaaatggcggagcagagttattttatcgaaaagaaagcattgaacagaaaaat

aggataactcataaggcaggatcaattcttgtaaacaaggtttgtaaggatggaa

caagtctagatgacaaaatcagaaacgaaatatatcaatatgaaaacaagtttat

tgatacattgtctgatgaagctaaaaaagttttacctaatgtaataaaaaaagaa

gcaactcacgacataacaaaagataagcgatttacatcagataagttctttttcc

attgcccattaacaattaactataaggaaggagatacaaaacaatttaacaatga

ggttttatctttccttagaggtaatccagacattaatatcatcggaattgacaga

ggagaaagaaaccttatatacgtaactgttattaatcagaaaggcgaaatacttg

acagcgtttcgtttaacacagtaacaaacaagtcgagcaaaattgaacaaactgt

tgattatgaggaaaagcttgctgttagggaaaaagaaagaatagaagcaaaaaga

tcctgggattcaatatcaaagatagcaaccttaaaagaaggttatctatcagcta

ttgttcatgagatatgcctactgatgatcaaacacaacgcaatcgttgtacttga

gaatctaaatgcaggatttaagagaattagaggaggattatcagaaaagtctgtt

tatcagaaattcgagaagatgcttattaacaaactaaattactttgtatctaaaa

aagaatcagactggaataaacctagtggacttttaaatggtttacaactttcaga

ccagttcgagtcatttgagaaattaggaattcaatctgggttcatcttctatgtt

cctgcagcatatacatctaagattgatcctacaacaggatttgcaaatgttctta

acttatccaaggtaagaaatgttgatgcaataaagagttttttcagtaatttcaa

tgaaatttcatatagcaaaaaagaagctctctttaaattctcttttgatttagat

tccttatcaaagaagggcttcagctcatttgtaaaattcagtaaatctaaatgga

atgtatatacatttggagagagaataataaaaccaaagaataagcaagggtatcg

tgaagataagagaattaatttaacatttgaaatgaaaaaacttctgaatgaatat

aaagtaagttttgatcttgaaaacaacttaattccaaatctaacctctgcaaatc

tgaaagataccttctggaaagaactattctttatttttaaaacaactctgcagct

tagaaacagtgtaacaaatggcaaagaagatgtactgatttctccagtaaagaac

gctaaaggagagttctttgtatcaggaactcataacaagacattacctcaagact

gtgatgcaaatggagcatatcatatcgccctaaaaggtctgatgattcttgaacg

taacaatcttgttagagaagaaaaagacacaaagaagataatggcaatttctaat

gttgactggtttgagtatgttcaaaaaaggagaggtgtcctgtaa

SEQ
ATGAACAACTATGATGAGTTTACCAAACTGTACCCAATACAGAAAACGATAAGGT

ID
TCGAATTGAAGCCGCAGGGAAGAACGATGGAACACCTCGAAACATTCAACTTTTT

NO:
CGAAGAGGACAGGGATAGAGCGGAGAAATATAAGATTTTAAAGGAAGCAATCGAC

23
GAGTATCATAAGAAGTTTATAGACGAACATCTAACAAATATGTCTCTTGACTGGA

ATTCTTTAAAACAGATTTCAGAGAAATACTATAAGAGTAGAGAGGAAAAAGACAA

GAAAGTTTTTCTGTCAGAACAGAAACGCATGAGGCAAGAGATAGTTTCTGAGTTC

AAAAAAGACGATCGGTTTAAAGATCTTTTTTCAAAAAAATTGTTTTCTGAACTTC

TCAAGGAAGAGATTTACAAAAAAGGAAACCATCAGGAAATTGACGCATTGAAAAG

TTTTGATAAATTCTCAGGCTATTTTATTGGGTTGCATGAGAACCGAAAAAATATG

TATTCTGACGGAGACGAGATCACGGCTATCTCTAACCGTATTGTAAATGAGAATT

TCCCGAAGTTCCTCGACAACCTTCAGAAATATCAGGAAGCTCGTAAAAAATATCC

AGAGTGGATCATTAAGGCAGAATCTGCTTTAGTTGCACATAATATCAAGATGGAT

GAAGTCTTTTCCTTAGAGTATTTCAACAAAGTCCTGAATCAAGAAGGAATACAGA

GATACAATCTCGCCCTAGGTGGCTATGTGACCAAAAGTGGTGAGAAAATGATGGG

GCTTAATGATGCACTTAATCTTGCCCATCAAAGTGAAAAAAGCAGCAAGGGAAGG

ATACACATGACTCCACTCTTCAAACAGATTCTGAGTGAAAAAGAGTCCTTTTCTT

ATATACCAGATGTTTTTACAGAAGACTCTCAACTTTTACCATCCATTGGTGGGTT

CTTTGCACAAATAGAAAATGATAAGGACGGGAATATTTTTGACAGAGCATTAGAA

TTGATATCTTCTTATGCAGAATACGATACAGAAAGGATATATATCAGGCAAGCGG

ACATAAACAGAGTTTCTAATGTTATTTTCGGGGAGTGGGGAACACTGGGGGGGTT

AATGAGGGAATACAAAGCAGACTCTATCAACGACATCAATTTGGAGAGAACATGC

AAGAAGGTAGACAAGTGGCTCGACTCAAAGGAGTTTGCGTTATCAGATGTATTAG

AGGCAATAAAAAGAACCGGCAATAATGATGCTTTTAATGAATATATCTCAAAGAT

GCGCACTGCCAGGGAAAAGATTGACGCTGCAAGAAAGGAAATGAAATTCATTTCG

GAAAAAATATCTGGAGACGAAGAATCGATCCATATTATCAAAACCTTATTGGACT

CGGTGCAACAGTTTTTACATTTTTTCAATTTATTCAAAGCGCGTCAGGACATTCC

TCTTGATGGAGCATTCTATGCGGAGTTCGATGAAGTCCATAGCAAACTGTTTGCT

ATTGTTCCGTTGTATAATAAGGTTAGGAACTATCTTACGAAAAATAACCTTAACA

CGAAAAAGATAAAGCTAAACTTCAAGAATCCAACTCTGGCAAACGGATGGGATCA

AAACAAGGTATATGACTACGCCTCCTTAATCTTTCTCCGCGATGGTAATTATTAT

CTCGGAATAATAAATCCAAAAAGGAAAAAGAATATTAAATTCGAACAAGGGTCTG

GAAATGGCCCATTCTACCGGAAGATGGTGTACAAACAAATTCCAGGGCCGAACAA

GAACTTACCAAGAGTCTTCCTCACATCTACGAAAGGCAAAAAAGAGTACAAGCCG

TCAAAGGAGATAATAGAAGGATATGAAGCGGACAAACACATAAGAGGAGATAAAT

TCGATCTGGATTTCTGTCATAAGCTGATAGACTTCTTCAAGGAATCCATCGAGAA

GCACAAGGACTGGAGTAAGTTCAACTTCTATTTCTCTCCAACTGAATCATATGGA

GACATCAGCGAATTCTATCTGGATGTAGAAAAACAGGGATACCGGATGCATTTTG

AGAATATTTCTGCCGAGACGATTGATGAGTATGTCGAAAAGGGGGACTTATTCCT

CTTCCAGATATACAACAAAGACTTTGTGAAAGCGGCAACCGGAAAAAAAGATATG

CACACCATTTATTGGAACGCGGCATTCTCGCCCGAGAACCTTCAGGATGTGGTAG

TGAAACTGAACGGTGAAGCAGAACTTTTCTACAGAGACAAGAGCGACATCAAGGA

GATAGTTCACAGGGAGGGAGAGATACTGGTCAATCGTACCTACAACGGCAGGACA

CCTGTGCCTGACAAGATCCACAAAAAATTAACAGATTATCATAATGGCCGTACCA

AAGATCTCGGAGAAGCAAAAGAATACCTCGATAAGGTCAGATATTTCAAAGCGCA

CTACGACATCACAAAGGATCGCAGATACCTGAATGATAAAATATACTTCCATGTG

CCTCTGACATTGAATTTCAAAGCAAACGGGAAGAAGAATCTCAATAAGATGGTAA

TTGAAAAGTTCCTCTCGGACGAAAAAGCGCATATTATTGGGATTGATCGCGGGGA

AAGGAATCTTCTTTACTATTCTATCATTGACAGGTCAGGTAAAATAATCGATCAA

CAGAGCCTCAACGTCATCGATGGATTCGATTACCGAGAGAAACTGAATCAGAGGG

AGATCGAGATGAAGGATGCCAGACAAAGCTGGAATGCTATCGGGAAGATAAAGGA

CCTCAAGGAAGGGTATCTTTCAAAAGCGGTCCACGAAATTACCAAGATGGCGATA

CAATACAATGCCATTGTTGTCATGGAGGAACTCAATTATGGGTTCAAACGCGGAC

GTTTCAAAGTTGAGAAGCAGATATATCAGAAATTCGAGAATATGCTGATTGACAA

GATGAATTATCTGGTATTCAAGGATGCTCCGGATGAAAGTCCGGGAGGAGTCCTC

AATGCATATCAGCTTACTAATCCGCTTGAAAGTTTCGCTAAACTTGGGAAACAGA

CAGGAATTCTTTTCTATGTTCCGGCAGCCTATACTTCGAAGATAGATCCGACGAC

CGGGTTTGTCAATCTTTTCAATACTTCAAGTAAAACGAACGCACAGGAAAGAAAA

GAATTCTTGCAAAAATTCGAGTCGATCTCCTATTCCGCTAAAGACGGAGGAATAT

TCGCATTCGCGTTCGATTATCGGAAGTTCGGAACGTCAAAAACAGACCACAAAAA

TGTATGGACCGCATACACGAACGGGGAAAGGATGAGGTACATAAAAGAGAAAAAA

CGCAACGAACTGTTCGACCCCTCGAAGGAGATCAAAGAGGCTCTCACTTCATCAG

GAATCAAATATGACGGCGGACAGAACATATTGCCAGATATCCTGAGGAGCAACAA

TAACGGTCTGATCTACACAATGTATTCCTCTTTCATAGCGGCCATTCAAATGAGG

GTCTATGACGGGAAAGAAGACTATATCATCTCGCCGATAAAGAACAGCAAGGGAG

AGTTCTTCAGGACCGATCCGAAAAGAAGGGAACTTCCGATAGACGCGGATGCGAA

CGGCGCGTATAACATTGCTCTCAGGGGCGAATTGACGATGCGTGCGATAGCGGAG

AAGTTCGATCCGGACTCGGAAAAGATGGCGAAGCTAGAACTGAAACATAAGGACT

GGTTCGAATTCATGCAGACAAGGGGGGATTGA

SEQ
ATGACAAAAACATTTGATTCAGAATTTTTTAATTTATATTCTCTTCAAAAAACAG

ID
TTCGTTTTGAACTCAAGCCGGTTGGTGAAACAGCCTCGTTTGTTGAAGATTTTAA

NO:
AAACGAAGGTTTGAAACGAGTTGTTTCAGAGGATGAACGGCGTGCGGTTGATTAC

24
CAAAAAGTGAAAGAAATTATTGATGACTACCACCGAGATTTTATTGAAGAATCGC

TGAACTATTTTCCTGAGCAGGTCTCAAAAGACGCTTTGGAACAAGCTTTTCACCT

TTATCAAAAACTAAAAGCCGCTAAGGTTGAAGAGCGTGAAAAAGCATTGAAAGAA

TGGGAAGCCCTTCAGAAAAAACTGCGCGAAAAAGTTGTTAAATGTTTTTCAGATT

CAAACAAAGCACGCTTTTCCCGCATTGATAAAAAAGAACTGATTAAAGAAGATTT

AATTAACTGGTTGGTTGCACAAAATCGCGAAGATGACATTCCAACCGTTGAAACC

TTTAACAACTTTACGACTTATTTTACGGGGTTTCATGAAAACCGAAAAAACATTT

ATTCAAAAGACGATCATGCCACAGCCATTTCATTTCGACTCATTCATGAAAACCT

GCCTAAGTTTTTTGATAATGTGATCAGCTTTAATAAATTGAAGGAAGGATTTCCA

GAGCTGAAATTTGATAAGGTTAAGGAAGATTTAGAAGTTGATTATGACTTGAAAC

ATGCCTTTGAAATCGAATACTTTGTCAATTTTGTTACCCAAGCCGGAATTGACCA

ATATAACTATCTTTTGGGGGGTAAAACCTTAGAAGACGGCACCAAAAAGCAAGGC

ATGAATGAACAAATCAATCTGTTCAAGCAACAGCAAACCCGAGACAAAGCCCGAC

AAATTCCCAAACTCATACCATTGTTTAAACAAATTCTAAGCGAACGAACGGAAAG

CCAATCGTTTATTCCAAAACAATTTGAATCAGACCAAGAGCTATTTGACTCACTG

CAAAAACTGCATAACAACTGCCAAGATAAATTTACCGTACTGCAACAAGCCATTT

TAGGCTTAGCCGAAGCAGATCTGAAAAAAGTATTCATTAAAACATCTGATCTTAA

TGCGCTATCAAATACCATTTTTGGAAATTACAGTGTGTTTTCGGATGCGTTGAAT

TTATACAAAGAATCGCTCAAAACAAAAAAGGCGCAAGAAGCGTTTGAAAAACTAC

CCGCTCACAGCATTCATGACTTGATTCAATATTTGGAGCAATTTAATAGCTCTTT

GGATGCAGAAAAACAGCAATCAACTGACACCGTACTGAATTACTTTATTAAAACA

GACGAGCTGTATTCTCGGTTCATAAAATCAACGAGCGAAGCCTTCACACAAGTAC

AACCACTCTTTGAATTGGAAGCATTAAGCTCAAAACGTCGTCCACCGGAAAGTGA

AGACGAAGGCGCAAAAGGTCAGGAAGGGTTTGAGCAAATTAAACGCATAAAAGCC

TATTTGGATACCTTGATGGAGGCGGTGCATTTTGCAAAACCACTTTATCTGGTGA

AGGGGCGCAAAATGATTGAAGGTCTGGACAAAGACCAAAGTTTCTATGAAGCCTT

TGAAATGGCTTACCAAGAACTAGAAAGTCTGATTATTCCAATCTACAACAAAGCT

CGTAGTTATTTAAGTCGTAAACCGTTTAAAGCGGACAAATTCAAAATTAATTTTG

ATAATAATACATTGCTTTCCGGTTGGGATGCTAATAAAGAAACGGCTAACGCTTC

AATTTTGTTTAAGAAGGATGGTTTGTATTATTTAGGAATCATGCCTAAAGGAAAA

ACGTTTTTGTTCGATTACTTCGTTTCATCGGAAGATTCTGAAAAGTTAAAACAAA

GAAGACAAAAAACCGCCGAAGAAGCGCTTGCGCAAGATGGCGAAAGCTACTTTGA

AAAAATTCGTTACAAGCTGTTACCTGGCGCCAGCAAAATGTTGCCGAAAGTATTT

TTTTCCAACAAAAACATAGGGTTTTACAACCCAAGTGATGACATACTTCGTATCA

GGAATACAGCCTCTCACACTAAAAACGGAACACCGCAAAAAGGGCACTCTAAAGT

AGAGTTTAATTTGAATGATTGTCATAAGATGATTGATTTCTTTAAATCAAGCATT

CAAAAGCATCCAGAGTGGGGAAGTTTTGGATTCACCTTTTCAGATACATCAGATT

TTGAAGATATGAGCGCCTTTTATCGAGAAGTCGAAAACCAAGGTTATGTCATTAG

TTTCGATAAAATAAAAGAAACTTACATTCAGAGTCAAGTTGAACAGGGGAACCTA

TATTTATTCCAAATCTACAATAAAGACTTCTCGCCCTACAGCAAAGGCAAACCAA

ATTTACACACGCTTTACTGGAAAGCGTTGTTTGAGGAAGCCAACCTAAATAATGT

GGTGGCAAAACTCAATGGTGAAGCTGAAATTTTCTTTAGGCGACACTCAATCAAA

GCATCTGATAAAGTGGTGCACCCAGCGAATCAAGCCATTGACAATAAAAACCCGC

ATACCGAAAAAACGCAAAGCACCTTTGAATATGATCTTGTAAAAGACAAGCGCTA

TACCCAAGACAAATTCTTCTTCCATGTACCGATTTCATTGAACTTTAAGGCACAA

GGTGTTTCAAAATTTAACGATAAAGTGAATGGATTTTTAAAGGGTAACCCAGATG

TCAATATTATTGGCATTGACCGAGGCGAACGACACCTTCTGTATTTCACTGTGGT

GAATCAGAAAGGTGAAATTTTGGTTCAAGAGTCGCTTAATACCCTAATGAGTGAT

AAAGGGCATGTGAATGACTACCAGCAAAAACTCGACAAAAAAGAACAAGAACGCG

ATGCCGCTCGCAAAAGCTGGACGACGGTTGAAAATATCAAAGAATTAAAAGAAGG

CTATTTATCTCATGTTGTTCATAAGTTGGCACACCTGATTATTAAATACAATGCC

ATTGTTTGCTTGGAAGACCTGAATTTTGGTTTCAAACGCGGGCGTTTTAAAGTGG

AAAAACAAGTTTATCAGAAATTTGAAAAAGCGCTTATTGATAAGCTTAACTACTT

GGTATTTAAAGAAAAAGAGTTAGGCGAGGTGGGCCATTATCTAACCGCCTATCAG

TTGACCGCACCGTTTGAAAGTTTCAAGAAGTTAGGCAAGCAAAGTGGCATATTGT

TTTATGTTCCGGCGGATTACACCTCCAAAATTGACCCAACCACCGGGTTTGTCAA

CTTTCTTGATCTGCGTTATCAGAGTGTCGAAAAAGCCAAACAGCTCTTAAGCGAC

TTTAATGCCATTCGTTTTAATTCAGTACAAAACTATTTTGAGTTCGAAATAGATT

ACAAAAAACTCACACCCAAACGTAAAGTTGGTACTCAGAGTAAATGGGTGATTTG

TACCTATGGAGATGTCCGCTATCAAAATCGGCGTAATCAAAAAGGTCACTGGGAA

ACGGAAGAAGTCAATGTGACTGAAAAACTAAAAGCCCTTTTCGCCAGTGATTCCA

AAACTACAACCGTAATCGATTACGCCAATGACGACAACCTAATTGACGTCATTCT

GGAACAGGACAAAGCCAGCTTCTTCAAAGAACTGTTATGGTTATTAAAACTCACC

ATGACGCTCCGCCACAGCAAAATCAAAAGTGAAGACGACTTTATTCTTTCACCCG

TTAAAAACGAACAAGGCGAGTTTTACGATAGTCGAAAAGCGGGCGAGGTGTGGCC

TAAAGATGCAGACGCCAATGGCGCTTATCACATAGCGTTGAAAGGCTTGTGGAAT

CTGCAACAGATCAATCAGTGGGAAAAGGGTAAAACACTTAATCTGGCGATTAAAA

ACCAGGATTGGTTCAGTTTTATTCAAGAAAAGCCCTATCAAGAATAA

SEQ
ATGCACACAGGCGGATTACTTAGCATGGATGCCAAGGAGTTTACCGGACAGTACC

ID
CCCTTTCGAAGACTCTGCGTTTTGAACTGAGACCGATAGGCAGAACGTGGGACAA

NO:
TCTCGAAGCATCGGGGTATCTTGCGGAGGACAGACACCGTGCAGAATGCTATCCC

25
AGGGCAAAAGAGCTCTTGGACGACAACCATCGTGCATTCCTCAACCGTGTCCTGC

CTCAGATCGATATGGATTGGCACCCGATCGCAGAGGCATTCTGCAAAGTCCACAA

GAATCCGGGAAACAAGGAATTGGCTCAGGATTACAATCTTCAGCTGTCCAAACGC

AGAAAGGAGATTTCGGCCTATCTGCAGGATGCGGACGGCTATAAAGGTCTGTTTG

CCAAACCTGCATTGGATGAAGCAATGAAGATCGCGAAAGAAAACGGAAATGAATC

GGACATAGAGGTTCTTGAGGCATTCAACGGTTTCTCCGTATACTTCACCGGATAT

CATGAGAGCAGGGAGAACATCTATTCGGACGAGGATATGGTGTCGGTAGCTTATC

GCATCACCGAAGACAATTTCCCGAGATTCGTTTCCAATGCGCTTATATTCGATAA

GCTGAATGAGTCGCACCCCGATATAATCTCGGAAGTATCCGGAAATCTGGGCGTA

GACGACATCGGAAAATATTTTGATGTGTCTAACTACAATAATTTCCTGTCGCAGG

CCGGTATAGATGACTACAATCACATCATCGGCGGCCATACGACGGAGGACGGTCT

GATCCAGGCATTCAATGTTGTTCTGAATCTCAGGCATCAGAAAGACCCCGGATTC

GAAAAAATCCAATTCAAACAGCTGTACAAACAGATACTCAGCGTCCGTACATCCA

AATCCTATATCCCGAAACAGTTCGATAATTCGAAGGAGATGGTGGACTGCATCTG

CGACTATGTGTCCAAGATCGAAAAATCCGAAACGGTCGAGAGAGCATTGAAGCTG

GTAAGGAACATATCTTCTTTTGATTTGCGCGGAATATTCGTAAACAAGAAGAATC

TCCGCATTCTTTCCAACAAACTGATTGGTGATTGGGACGCGATCGAAACCGCGCT

GATGCACTCCTCCTCTTCGGAAAATGATAAGAAATCCGTCTACGACAGCGCCGAG

GCATTTACGCTGGATGATATCTTTTCGTCCGTTAAAAAATTCTCAGATGCATCTG

CAGAGGATATCGGAAACCGGGCGGAGGACATATGCAGAGTCATATCTGAGACCGC

TCCGTTCATAAACGATCTGAGGGCTGTCGATTTGGACAGTTTGAATGACGACGGT

TACGAGGCGGCGGTTTCCAAGATAAGGGAATCTCTGGAACCATATATGGATCTGT

TTCATGAACTGGAGATATTCTCCGTAGGCGATGAATTCCCGAAATGTGCAGCTTT

CTACAGTGAACTTGAAGAAGTCTCCGAACAGCTAATCGAGATTATACCGTTATTC

AACAAGGCCCGTTCGTTCTGTACGCGCAAGAGATACAGTACGGACAAGATAAAGG

TCAATTTGAAATTCCCGACACTCGCCGACGGATGGGATCTCAACAAAGAACGCGA

CAACAAAGCCGCAATACTCAGGAAAGACGGAAAGTACTACCTGGCCATACTGGAT

ATGAAGAAAGATCTTTCTTCGATCAGAACTTCGGATGAAGACGAATCCAGTTTTG

AGAAAATGGAGTACAAGCTTCTTCCGAGTCCGGTAAAGATGCTGCCAAAGATCTT

CGTAAAATCGAAGGCGGCCAAGGAGAAGTACGGTCTGACCGACCGTATGCTGGAG

TGCTACGATAAAGGGATGCACAAGAGCGGCAGTGCATTCGATCTCGGATTTTGTC

ACGAATTGATCGATTACTACAAGAGGTGCATCGCAGAATATCCCGGCTGGGACGT

CTTCGATTTCAAGTTCAGGGAAACATCGGATTATGGCAGCATGAAGGAGTTCAAT

GAGGATGTTGCAGGGGCCGGATACTATATGTCCCTCAGAAAGATCCCTTGTTCGG

AGGTCTACAGGCTTCTTGATGAGAAATCGATATATCTTTTCCAGATCTACAACAA

AGATTATTCGGAAAACGCTCATGGGAATAAGAACATGCATACCATGTATTGGGAA

GGGCTCTTTTCCCCCCAGAATCTGGAATCCCCTGTGTTTAAACTCAGCGGCGGTG

CGGAGCTTTTCTTCCGTAAATCCTCCATACCCAATGACGCCAAAACGGTCCATCC

GAAGGGAAGCGTCCTGGTTCCGCGCAATGATGTAAACGGCCGCAGGATACCTGAC

AGCATATATCGGGAGCTCACCAGATATTTCAACCGCGGAGATTGCCGCATAAGCG

ACGAGGCAAAGAGTTATCTGGACAAGGTGAAAACCAAGAAAGCTGACCACGATAT

CGTGAAAGACAGGAGGTTCACGGTGGACAAGATGATGTTCCACGTCCCTATCGCC

ATGAATTTCAAAGCGATTTCGAAGCCGAATCTCAATAAAAAGGTGATTGACGGCA

TAATCGACGACCAAGATCTGAAGATCATCGGCATAGACCGCGGAGAGCGCAACCT

CATCTACGTAACCATGGTGGATCGCAAAGGGAACATCCTCTATCAGGATAGCCTC

AATATTCTGAACGGATACGATTACCGTAAGGCCCTCGACGTCCGCGAATATGACA

ATAAAGAGGCTCGGAGGAACTGGACGAAGGTCGAAGGCATCCGTAAGATGAAAGA

GGGGTATCTGTCGCTTGCAGTCAGCAAATTGGCAGATATGATCATAGAGAACAAT

GCGATTATCGTCATGGAGGATCTCAATCACGGATTCAAGGCAGGGCGTTCGAAGA

TAGAGAAACAGGTCTATCAGAAGTTCGAATCCATGCTCATAAACAAACTCGGTTA

CATGGTCCTCAAGGATAAGTCTATCGATCAGAGCGGCGGAGCTCTCCACGGATAC

CAGCTTGCCAACCATGTGACAACATTGGCATCTGTAGGTAAACAATGTGGAGTGA

TATTCTACATCCCTGCTGCATTTACATCCAAGATAGATCCGACAACAGGATTTGC

AGATCTGTTCGCCCTCAGCAATGTTAAAAACGTGGCATCTATGAGAGAATTTTTC

TCCAAGATGAAGTCTGTAATCTATGATAAGGCGGAGGGAAAATTCGCATTTACCT

TCGACTATCTTGATTATAATGTGAAATCCGAGTGCGGAAGGACCCTTTGGACCGT

GTATACGGTCGGAGAGAGATTCACATACAGCAGGGTCAATAGAGAATATGTCAGA

AAAGTTCCGACAGACATAATCTACGACGCATTGCAAAAGGCAGGAATATCTGTTG

AAGGGGATCTCAGGGACAGGATTGCTGAATCGGATGGCGACACTCTGAAGAGCAT

ATTCTATGCATTCAAGTATGCATTGGATATGAGAGTAGAGAACCGCGAAGAGGAT

TACATACAGTCTCCTGTCAAAAATGCCTCCGGAGAATTCTTCTGTTCCAAGAACG

CAGGCAAATCGCTCCCTCAGGATTCCGATGCGAACGGTGCATACAATATCGCACT

CAAGGGGATCCTGCAGCTACGTATGCTTTCCGAGCAGTATGATCCGAATGCAGAG

AGCATACGGTTGCCACTGATAACCAACAAGGCCTGGCTGACCTTTATGCAGTCCG

GTATGAAGACATGGAAGAACTGA

SEQ
atgGATAGTTTGAAAGATTTCACCAATCTGTACCCTGTCAGTAAGACATTGAGAT

ID
TTGAATTAAAGCCCGTTGGAAAGACTTTAGAAAATATCGAGAAAGCAGGTATTTT

NO:
GAAAGAGGATGAGCATCGTGCAGAAAGTTATCGGAGGGTGAAGAAAATAATTGAT

26
ACTTATCATAAGGTATTTATCGATTCTTCTCTTGAAAATATGGCTAAAATGGGTA

TTGAGAATGAAATAAAAGCAATGCTCCAAAGTTTCTGCGAATTGTATAAAAAAGA

TCATCGCACTGAGGGTGAAGACAAGGCATTAGATAAAATTCGAGCAGTACTTCGT

GGCCTGATTGTTGGGGCTTTCACTGGTGTTTGCGGAAGACGGGAAAATACAGTCC

AAAACGAGAAGTACGAGAGTTTGTTCAAAGAAAAGTTGATAAAAGAAATTTTACC

TGATTTTGTGCTCTCTACTGAGGCTGAAAGCTTGCCTTTCTCTGTTGAAGAAGCT

ACGAGGTCACTGAAGGAGTTTGATAGCTTTACATCCTACTTTGCTGGTTTTTACG

AGAATAGAAAGAATATATACTCGACGAAACCTCAATCCACTGCCATTGCTTATCG

TCTTATTCATGAGAACTTGCCGAAGTTCATTGATAATATTCTTGTTTTTCAGAAG

ATCAAAGAGCCTATAGCCAAAGAGCTGGAACATATTCGTGCGGACTTTTCTGCCG

GGGGGTACATAAAAAAGGATGAGAGATTGGAGGATATTTTTTCGTTGAACTATTA

TATCCACGTGTTATCTCAGGCTGGGATCGAAAAATATAACGCATTGATTGGGAAG

ATTGTGACAGAAGGAGATGGAGAGATGAAAGGGCTCAATGAACACATCAACCTTT

ACAACCAACAAAGAGGCAGAGAGGATCGGCTCCCTCTTTTTAGGCCTCTTTATAA

ACAGATATTGAGTGACAGAGAGCAATTATCATACTTGCCTGAGAGTTTTGAAAAA

GATGAGGAGCTCCTCAGGGCTCTAAAAGAGTTCTATGATCATATCGCAGAAGACA

TTCTCGGACGTACTCAACAGTTGATGACTTCTATTTCAGAATATGATTTATCTCG

GATATACGTAAGGAACGATAGCCAATTGACTGATATATCAAAAAAAATGTTGGGA

GATTGGAATGCTATCTACATGGCTAGAGAACGAGCATATGACCACGAGCAGGCTC

CCAAAAGAATCACGGCGAAATACGAGAGGGACAGGATTAAAGCTCTTAAAGGAGA

AGAGAGTATAAGTCTGGCAAATCTTAATAGTTGTATTGCCTTTCTGGACAATGTT

AGAGATTGCCGTGTAGATACTTATCTTTCCACACTGGGCCAGAAGGAAGGACCAC

ATGGTCTATCTAATCTCGTTGAGAACGTTTTTGCCTCATACCATGAAGCAGAGCA

ATTGTTGAGCTTTCCATACCCCGAAGAGAATAATCTGATTCAGGACAAGGACAAT

GTGGTGTTAATTAAGAATCTTCTCGACAATATCAGTGATCTGCAGAGGTTCTTGA

AACCTCTTTGGGGTATGGGAGACGAACCCGATAAAGATGAAAGATTTTATGGAGA

GTATAATTATATCCGAGGAGCTCTAGATCAGGTGATCCCTCTGTACAATAAGGTA

AGGAACTACCTCACTCGGAAGCCTTATTCGACCAGAAAAGTAAAACTCAATTTTG

GGAATTCTCAATTGCTTAGTGGTTGGGATAGAAATAAGGAAAAGGATAATAGCTG

TGTGATTTTGCGTAAGGGGCAGAACTTCTATTTGGCTATTATGAACAATAGGCAC

AAAAGAAGTTTCGAAAACAAGGTGTTGCCCGAGTATAAGGAGGGAGAACCTTACT

TCGAAAAGATGGATTATAAATTTTTGCCTGATCCTAATAAAATGCTTCCTAAGGT

TTTTCTTTCGAAAAAAGGAATAGAGATATACAAACCAAGTCCGAAGCTTTTAGAA

CAATATGGACATGGAACTCACAAAAAGGGAGATACCTTTAGTATGGATGATTTGC

ACGAACTGATCGATTTCTTCAAACACTCAATCGAGGCTCATGAAGATTGGAAGCA

ATTCGGATTCAAATTTTCTGATACGGCTACTTATGAGAATGTATCTAGTTTCTAT

AGAGAAGTTGAGGATCAGGGGTATAAGCTCTCTTTCCGAAAAGTTTCGGAATCTT

ATGTCTATTCATTAATAGATCAAGGCAAGTTGTATTTATTTCAGATATACAACAA

GGACTTTTCTCCCTGCAGCAAAGGGACACCTAATCTGCATACCTTGTATTGGAGA

ATGCTTTTTGACGAGCGCAATTTGGCAGATGTCATATACAAACTGGATGGGAAGG

CTGAAATCTTTTTCCGAGAGAAGAGTTTGAAAAATGATCATCCCACGCATCCGGC

TGGTAAGCCTATCAAAAAGAAAAGTCGACAAAAAAAAGGAGAGGAGAGTCTGTTT

GAGTATGATTTAGTCAAGGATAGGCACTATACGATGGATAAGTTCCAGTTTCATG

TGCCTATTACTATGAATTTTAAATGTTCTGCAGGAAGCAAAGTCAATGATATGGT

TAATGCTCATATTCGAGAGGCAAAGGATATGCATGTCATTGGAATTGATCGTGGA

GAACGCAATCTGCTGTATATATGCGTGATAGATAGTCGAGGGACGATTTTGGATC

AAATTTCTCTGAATACGATTAACGATATAGACTATCATGATTTATTGGAGAGTCG

AGACAAAGACCGTCAGCAGGAGCGCCGAAACTGGCAAACTATCGAAGGGATCAAG

GAGCTAAAACAAGGCTACCTTAGTCAGGCGGTTCATCGGATAGCCGAACTGATGG

TGGCTTATAAGGCTGTAGTTGCTTTGGAGGATTTGAATATGGGGTTCAAACGTGG

GCGGCAGAAAGTAGAAAGTTCTGTTTATCAGCAGTTTGAGAAACAGCTGATAGAT

AAGCTCAACTATCTTGTGGACAAGAAGAAAAGGCCTGAAGATATTGGAGGATTGT

TGAGAGCCTATCAATTTACGGCCCCATTTAAGAGTTTTAAGGAAATGGGAAAGCA

AAACGGCTTCTTGTTTTATATCCCGGCTTGGAACACGAGCAACATAGATCCGACT

ACTGGATTTGTTAATTTATTTCATGCCCAGTATGAAAATGTAGATAAAGCGAAGA

GCTTCTTTCAAAAGTTTGATTCAATTAGTTACAACCCGAAGAAAGACTGGTTTGA

GTTTGCATTCGATTATAAAAACTTTACTAAAAAGGCTGAAGGAAGTCGTTCTATG

TGGATATTATGCACACATGGTTCCCGAATAAAGAATTTTAGAAATTCCCAGAAGA

ATGGTCAATGGGATTCCGAAGAATTCGCCTTGACGGAGGCTTTTAAGTCTCTTTT

TGTGCGATATGAGATAGATTATACCGCTGATTTGAAAACAGCTATTGTGGACGAA

AAGCAAAAAGACTTCTTCGTGGATCTTCTGAAGCTATTCAAATTGACAGTACAGA

TGCGCAACAGCTGGAAAGAGAAGGATTTGGATTATCTAATCTCTCCTGTAGCAGG

GGCTGATGGCCGTTTCTTCGATACAAGAGAGGGAAATAAAAGTCTGCCTAAGGAT

GCAGATGCCAATGGAGCTTATAATATTGCCCTAAAAGGACTTTGGGCTCTACGCC

AGATTCGGCAAACTTCAGAAGGCGGTAAACTCAAATTGGCGATTTCCAATAAGGA

ATGGCTACAGTTTGTGCAAGAGAGATCTTACGAGAAAGACtga

SEQ
atgaataatggaacaaataactttcagaattttatcggaatttcttctttgcaga

ID
agactcttaggaatgctctcattccaaccgaaacaacacagcaatttattgttaa

NO:
aaacggaataattaaagaagatgagctaagaggagaaaatcgtcagatacttaaa

27
gatatcatggatgattattacagaggtttcatttcagaaactttatcgtcaattg

atgatattgactggacttctttatttgagaaaatggaaattcagttaaaaaatgg

agataacaaagacactcttataaaagaacagactgaataccgtaaggcaattcat

aaaaaatttgcaaatgatgatagatttaaaaatatgttcagtgcaaaattaatct

cagatattcttcctgaatttgtcattcataacaataattattctgcatcagaaaa

ggaagaaaaaacacaggtaattaaattattttccagatttgcaacgtcattcaag

gactattttaaaaacagggctaattgtttttcggctgatgatatatcttcatctt

cttgtcatagaatagttaatgataatgcagagatattttttagtaatgcattggt

gtataggagaattgtaaaaagtctttcaaatgatgatataaataaaatatccgga

gatatgaaggattcattaaaggaaatgtctctggaagaaatttattcttatgaaa

aatatggggaatttattacacaggaaggtatatctttttataatgatatatgtgg

taaagtaaattcatttatgaatttatattgccagaaaaataaagaaaacaaaaat

ctctataagctgcaaaagcttcataaacagatactgtgcatagcagatacttctt

atgaggtgccgtataaatttgaatcagatgaagaggtttatcaatcagtgaatgg

atttttggacaatattagttcgaaacatatcgttgaaagattgcgtaagattgga

gacaactataacggctacaatcttgataagatttatattgttagtaaattctatg

aatcagtttcacaaaagacatatagagattgggaaacaataaatactgcattaga

aattcattacaacaatatattacccggaaatggtaaatctaaagctgacaaggta

aaaaaagcggtaaagaatgatctgcaaaaaagcattactgaaatcaatgagcttg

ttagcaattataaattatgttcggatgataatattaaagctgagacatatataca

tgaaatatcacatattttgaataattttgaagcacaggagcttaagtataatcct

gaaattcatctggtggaaagtgaattgaaagcatctgaattaaaaaatgttctcg

atgtaataatgaatgcttttcattggtgttcggttttcatgacagaggagctggt

agataaagataataatttttatgccgagttagaagagatatatgacgaaatatat

ccggtaatttcattgtataatcttgtgcgtaattatgtaacgcagaagccatata

gtacaaaaaaaattaaattgaattttggtattcctacactagcggatggatggag

taaaagtaaagaatatagtaataatgcaattattctcatgcgtgataatttgtac

tatttaggaatatttaatgcaaaaaataagcctgacaaaaagataattgaaggta

atacatcagaaaataaaggggattataagaagatgatttataatcttctgccagg

accaaataaaatgatccccaaggtattcctctcttcaaaaaccggagtggaaaca

tataagccgtctgcctatatattggagggctataaacaaaacaagcatattaaat

cctctaaggattttgatataacattttgtcacgatttgattgattattttaagaa

ctgtatagcaatacatcctgaatggaagaattttggctttgatttttctgacacc

tccacatatgaagatatcagcggattttacagagaagtcgaattacaaggttata

aaatcgactggacatatatcagcgaaaaggatattgatttgttgcaggaaaaagg

acagttatatttattccaaatatataacaaagatttttccaagaaaagtaccgga

aatgataatcttcatactatgtatttgaagaatttgtttagtgaagagaatttaa

aggatattgtactgaaattaaacggtgaggcggaaatcttctttagaaaatcaag

cataaagaatccaataattcataaaaaaggctctattcttgttaatagaacatat

gaagcagaggaaaaagatcaatttggaaatatccagatagtcagaaaaaacatac

cggaaaatatatatcaggagctttataaatatttcaatgataaaagtgataaaga

actttcggatgaagcagctaagcttaagaatgtagtaggtcatcatgaggctgct

acaaacatagtaaaagattatagatatacatatgataaatattttcttcatatgc

ctattacaatcaattttaaagccaataagacaggctttattaatgacagaatatt

acaatatattgctaaagaaaaggatttgcatgtaataggcattgatcgtggtgaa

agaaacctgatatatgtttcagtaattgatacttgtggaaatattgttgaacaaa

aatcgtttaacattgttaatggatatgattatcagattaagctcaagcagcagga

gggggcgcgacaaatcgcacgaaaagaatggaaagaaatcggcaaaataaaagaa

attaaagaaggctatttatctcttgtaattcatgaaatttcaaagatggttatta

aatataatgccataattgcaatggaggatttaagctacggatttaaaaaaggtcg

tttcaaggttgagcgacaggtttaccagaagtttgagacaatgcttatcaacaaa

ctcaactatctggtatttaaagatatatccataacggaaaacggtggtcttctaa

agggataccagcttacatatattccagataaactgaaaaatgtgggtcatcaatg

tggctgtatattttatgtacctgctgcctatacatcaaaaatagatcctacaacc

ggatttgtaaatatattcaaatttaaagatttaacagttgatgcgaagagagaat

ttataaaaaaatttgacagtatcagatatgattcagaaaaaaatctgttttgttt

tacattcgattataataactttattacgcaaaatactgttatgtcaaagtcaagc

tggagtgtatatacgtacggagttaggataaaaagaagatttgtcaatggcaggt

tctcaaatgaatcggatacaattgatataacaaaagatatggaaaaaacactcga

aatgacagatataaattggagagatggtcatgatctgaggcaggatattattgat

tatgaaatcgtacaacacatatttgagatttttagattgactgtacaaatgagaa

acagtttaagtgaattagaagacagggattatgaccgtttgatttctccggtgct

caatgaaaataatatattttatgattcagctaaagcaggagatgcgttacctaaa

gacgcagatgctaatggtgcatattgtatagctctaaaaggcttgtatgaaatca

aacaaattacagagaattggaaagaagacggtaagttttcaagagataaacttaa

aatttccaataaggactggtttgactttattcaaaataaaaggtatttataa

SEQ
atgacaaacaaatttacaaaccagtactcgctttccaaaacacttcgatttgagt

ID
tgattccacaaggaaaaacattggaatttattcaagaaaaaggattgctctctca

NO:
agataaacaacgagcggagagttatcaagaaatgaaaaaaactattgataaattt

28
cataaatactttatcgatttagctttaagcaatgctaaactaactcatttagaaa

cttacttggaattatacaataaaagtgctgaaacaaaaaaagaacaaaaatttaa

agacgatttaaagaaagtacaagacaatttacgaaaagaaatcgttaaatctttt

tcagatggtgatgcaaaatcaatttttgcaattttggataaaaaagaactgatta

ccgtagaacttgaaaaatggtttgaaaacaacgaacaaaaagacatttattttga

cgaaaaattcaaaacgtttactacttattttactggttttcatcaaaacagaaaa

aacatgtattcggttgaacccaattctacagcaattgcttatcgattgattcatg

aaaatttacctaaatttttagaaaatgctaaagcatttgaaaaaataaaacaagt

agaaagtttgcaagttaattttagagaattaatgggggaatttggagatgaaggg

ctaattttcgtaaatgaattagaagaaatgtttcaaatcaattattataatgatg

tgctttcacaaaatggaattacaatttataatagtataatttcaggatttaccaa

aaatgatataaaatataaaggtctaaatgaatacataaataattacaatcaaacc

aaagacaaaaaagaccgtttgccaaaattaaaacaattgtataaacagattttga

gtgataggatttcactttcgtttttgcccgatgcttttacggatgggaaacaagt

tttgaaagccatatttgacttttataaaatcaacttactttcttataccattgaa

ggacaggaagaaagccaaaatcttttactattaattcgtcagacaattgaaaacc

tttctagttttgatacccaaaaaatttatctaaaaaatgatacccatttaaccac

tatttcacaacaagtatttggcgatttttcggtgttttcaactgctttaaattat

tggtatgaaactaaagtaaatccaaaatttgaaacggaatatagcaaagccaacg

aaaaaaaacgagaaattttagataaagccaaagcggtatttacaaaacaagatta

tttttcaattgcttttttacaagaagtactttcggaatacattcttaccttagat

cacacttctgatattgtaaaaaagcattcctccaactgtattgcggattatttta

aaaatcattttgtagccaaaaaagaaaatgaaaccgacaaaacctttgattttat

tgctaatattactgcaaaataccaatgtattcaaggtattttagaaaatgcagac

caatacgaagacgaactcaaacaagaccaaaaattaattgataatttgaaattct

ttttagatgctattttagaattgttgcattttattaaacctttgcatttaaaatc

agaaagcattaccgaaaaagacactgctttttatgatgtgtttgaaaattattac

gaagcattgagtttgttgaccccattatataatatggtgcgaaactatgtaacgc

aaaagccgtacagcaccgaaaaaataaaattaaattttgaaaatgcacaattatt

gaatggttgggatgccaataaagaaggtgattacctaactaccattttgaaaaaa

gacggtaattattttttagccataatggataaaaagcataacaaagcgtttcaaa

agtttccagaaggaaaagaaaattatgaaaaaatggtgtataaactattgcctgg

agtaaataagatgttgccaaaagtatttttttccaataaaaatattgcttacttc

aacccatcaaaagagttattagaaaactataaaaaagagacgcacaaaaaaggag

acacattcaatttagaacattgtcatacgttgatcgattttttcaaggactcttt

aaacaaacatgaagactggaaatactttgattttcaattttctgaaacaaaatcg

tatcaagatttgagtggtttttatagagaagtagaacatcaaggctacaaaatca

attttaaaaatatcgattcagaatatattgatggtttggtgaacgaaggtaaatt

gtttctatttcaaatttacagcaaagatttttcgcctttttccaaagggaaaccg

aacatgcacactttgtattggaaagccttatttgaagaacaaaatttgcaaaatg

taatctataaattgaatggacaagccgaaatattttttagaaaagcctctataaa

acctaaaaatataatattgcacaaaaagaaaattaaaattgccaaaaagcatttt

attgataaaaaaacaaaaacatctgaaattgttcctgttcaaacaataaaaaacc

tcaatatgtactaccaaggaaaaataagtgaaaaagaattaacacaagatgattt

aaggtatattgataattttagcattttcaatgaaaaaaataaaacaattgatatt

ataaaagacaaacgatttacggttgataaatttcagtttcatgtgccgattacca

tgaactttaaagcaacgggcggaagttatatcaatcaaaccgtattagaatattt

gcaaaacaatcccgaagttaagattattggattggatagaggcgaacgccatttg

gtatatctgacactgatagaccagcaaggaaacatcttgaaacaagaaagtttga

atacaatcaccgattctaaaatctcgacaccttatcataagttgttggataacaa

ggaaaacgagcgtgacttggctcgaaaaaattggggaacggtggaaaacatcaaa

gaactcaaagaaggctacatcagtcaagtggtgcataaaattgctacgttgatgc

tggaagaaaatgccattgtggtaatggaagatttgaattttggatttaaacgtgg

acgttttaaagtggaaaaacaaatttatcaaaagctggaaaaaatgttgattgac

aaattgaattatttggttttaaaagacaaacaacctcaggaattaggcggattgt

acaacgcattacaactcaccaataaatttgaaagtttccaaaaaatgggtaaaca

atcgggctttttttttatgtacccgcttggaacacctccaaaatagacccaacca

cagggtttgtcaattatttttataccaaatatgaaaatgttgacaaagccaaagc

cttttttgaaaaatttgaggcgattcgtttcaatgcagaaaagaagtattttgaa

tttgaagtaaaaaaatatagcgattttaacccaaaagccgaaggcactcaacaag

cctggaccatttgcacgtatggcgaacgaatagaaaccaaacgacaaaaagacca

aaacaacaaatttgtaagcactccaattaatctaaccgaaaagatagaagacttt

ttgggtaaaaaccaaattgtttatggtgatggtaattgcatcaaatctcaaattg

ctagcaaagacgacaaggctttttttgaaaccttattgtattggttcaaaatgac

tttacaaatgcgaaacagcgaaacaagaacagatatagattatctaatttcgccc

gtgatgaatgacaacggaacattttacaacagccgagattatgaaaaattagaaa

atccaactttgcccaaagatgccgatgccaacggagcgtatcatattgccaaaaa

aggattgatgcttttgaataaaatagaccaagccgacttgacaaaaaaagtggat

ttatctattagtaacagagattggttgcaatttgtacaaaaaaataaataa

SEQ
atggaacaggagtactatttaggactggatatgggaaccggatctgtaggatggg

ID
ctgttacagattcggaatatcatgtcttgcgtaaacatggaaaagcactatgggg

NO:
agtccgattatttgaaagtgcatcgacagcagaagaacgaagaatgttccgaaca

29
tcaagaagaagactagatcgaagaaactggagaattgaaattttacaggaaattt

ttgcagaggaaataagtaagaaagatccaggatttttcttgcgaatgaaagaaag

caaatattatccagaagataagcgagatatcaatggaaattgtccggaactgcca

tatgcattatttgttgatgacgattttacagataaagattatcataaaaaatttc

cgacaatttatcatctcaggaaaatgttgatgaatacagaggagacaccggatat

ccggttggtgtatctggcaattcatcatatgatgaagcataggggccatttcttg

ttatctggtgacattaatgagattaaggagttcggaacgacattttcaaaattgt

tggagaatatcaaaaatgaggaattggattggaatcttgaactgggaaaagaaga

atatgctgttgtagaaagtattttaaaagataacatgttaaaccgatccacaaag

aaaaccagattaataaaagcattaaaagcaaaatcaatatgtgaaaaggctgtac

tgaatttattggctggtggaacggtgaaattgagtgatatatttggtcttgaaga

attaaatgagacagaaagaccgaagatttcctttgctgataatggatacgatgat

tatatcggagaagttgaaaatgagctgggagaacaattctatattatagagacgg

caaaagcagtgtatgactgggcggtattagttgaaatattgggaaaatatacgtc

aatttcagaagcgaaagtagcaacgtatgaaaaacataaatcggatttacaattt

ttgaaaaagatagttcggaaatatctgacaaaggaggaatataaagatatttttg

taagtacgagtgacaaattgaaaaattactctgcttatataggaatgacgaaaat

aaatggaaaaaaggttgatttgcagagcaaacggtgcagtaaagaagaattctat

gattttattaagaaaaacgtacttaaaaagctagaaggacaacctgaatatgaat

atttgaaagaagagctagaaagagaaacatttctaccaaaacaggtgaacaggga

taatggtgtaataccgtatcagattcatttgtacgagttgaaaaagatattagga

aatttacgggataaaatagacctcattaaagagaacgaagataaactggttcaat

tatttgaattcagaattccgtattatgttggtccgctgaataagatagatgacgg

aaaagagggaaaatttacatgggctgtacggaaaagtaatgaaaagatatatcca

tggaattttgaaaatgtagttgatatagaagcaagtgcagaaaaatttatccgga

gaatgacaaataagtgtacatatctgatgggcgaagatgtattgccgaaggattc

attgctttacagtaaatatatggttttaaatgaattaaataatgtaaagttggat

ggcgaaaaattatctgtagaattgaaacaacggttgtatacagatgtattttgta

agtatcggaaagtaactgtaaagaagataaaaaattacttgaaatgtgaaggtat

catatccggcaatgtcgaaataactggaattgatggtgattttaaggcatcgtta

acggcatatcatgattttaaagaaatcttgacaggaacagaattggctaaaaagg

acaaagaaaatattattaccaatatagtattgtttggagatgataaaaagctgct

gaaaaagagactgaatcgattatatcctcagattacgccgaatcagttgaagaaa

atatgtgcgctatcctatacaggctggggaagattttctaaaaagttcttagaag

aaataacagctccagatccggaaacgggagaggtatggaatatcattacggcatt

gtgggaatcgaataataatctgatgcaattattaagtaatgaatatcggtttatg

gaagaagtcgaaacatacaatatgggaaaacagactaaaacattgtcgtacgaaa

cagtagagaatatgtatgtttctccatctgtgaaaagacagatatggcagacgct

gaaaatcgtgaaagaattagaaaaagtaatgaaagaatctccgaaacgtgtattt

attgagatggcgagagaaaagcaagaaagtaagagaaccgaatcgcgtaaaaaac

aactaatagatttgtataaggcttgtaaaaatgaagaaaaagattgggtaaaaga

actgggagatcaggaagaacagaaattacgaagcgataagttgtacctatattat

acgcaaaagggtcgttgtatgtattctggcgaggtaatagaactgaaagacttat

gggataatacaaaatatgatattgatcatatatatccacaatctaaaacgatgga

tgacagtcttaataatcgcgtattggtaaaaaagaaatataatgcaacaaaatca

gataagtatccattaaatgaaaatatacgacatgagagaaaaggcttttggaagt

cactgttagatggagggtttataagtaaagaaaaatatgaacgcttaataagaaa

tacagaattgagtccggaagaattagcaggatttattgaaaggcagattgttgaa

acgaggcagagtacaaaagctgtagcggaaatattaaagcaagtgtttccggaaa

gtgaaattgtatatgtcaaagcaggtacggtttcaagattcagaaaagattttga

attactgaaagttcgagaagtgaatgatttgcatcacgcaaaggatgcgtattta

aatattgtagttggtaatagttattatgtgaaatttactaagaatgcatcatggt

ttataaaagaaaatccgggacgtacttacaacttaaaaaagatgtttacatcagg

ttggaatattgaacgaaatggagaagttgcatgggaagtcgggaaaaaaggaaca

attgtaacggtaaaacaaataatgaataaaaataatatattggtgacaagacagg

ttcatgaagcgaaaggtgggctgtttgatcagcagattatgaaaaaaggaaaagg

tcagattgctataaaggaaactgatgaacgtcttgcatcaatagaaaagtatgga

ggctataataaagctgccggggcatattttatgctggtagaatctaaagataaaa

aaggaaaaacaattcgaacgatagaatttataccattatatttaaagaataaaat

cgagtcggatgaatcaatagcattgaactttttagaaaaaggcagaggtttgaaa

gaaccaaagatactattgaaaaaaattaagattgatacattatttgatgtggacg

gattcaaaatgtggttgtctggaagaacaggggacagactactatttaaatgtgc

aaatcaattgattttggatgagaaaataattgtaacaatgaaaaaaattgtaaag

tttattcaaaggagacaagaaaatagagaattaaaattatctgataaagatggaa

ttgataatgaagtacttatggaaatatataacacttttgtggataagttagaaaa

cacagtgtatagaatacgattatccgaacaggcaaaaacgcttatagataaacaa

aaagaatttgaaaggttatcactagaggataaaagtagtactttgtttgaaattt

tacatatttttcagtgtcaaagtagtgcggccaatttaaaaatgataggcggacc

tggaaaagcaggaatattagttatgaataataatataagtaagtgtaacaaaatt

tctattataaatcagtctccaacaggaattttcgaaaatgagattgatttgttaa

agat

SEQ
ATGAAATCTTTCGATTCATTCACAAATCTTTATTCTCTTTCAAAAACCTTGAAAT

ID
TTGAGATGAGACCTGTCGGAAATACCCAAAAAATGCTCGACAATGCAGGAGTATT

NO:
TGAAAAAGACAAACTAATTCAAAAAAAGTACGGAAAAACAAAGCCGTATTTCGAC

30
AGACTCCACAGAGAATTTATAGAAGAAGCGCTCACGGGGGTAGAGCTAATAGGAC

TAGATGAGAACTTTAGGACACTTGTTGACTGGCAAAAAGATAAGAAAAATAATGT

CGCAATGAAAGCGTATGAAAATAGTTTGCAGCGGCTGAGAACGGAAATAGGTAAA

ATATTTAACCTAAAGGCTGAGGATTGGGTAAAGAACAAATATCCAATATTAGGGC

TGAAAAATAAAAATACCGATATTTTATTCGAAGAGGCTGTATTCGGGATATTGAA

AGCCCGATATGGAGAAGAAAAAGATACTTTTATAGAAGTAGAGGAAATAGATAAA

ACCGGCAAATCAAAGATCAATCAAATATCAATTTTCGATAGTTGGAAAGGATTTA

CAGGATATTTCAAAAAATTTTTTGAAACCAGAAAGAATTTTTACAAAAACGACGG

AACTTCTACAGCAATTGCTACAAGGATCATTGATCAAAATCTGAAAAGATTCATA

GATAATCTGTCAATAGTTGAAAGTGTGAGACAAAAGGTTGATCTCGCCGAGACAG

AAAAATCTTTCAGCATATCTCTATCGCAATTCTTCTCAATAGACTTTTATAACAA

GTGTCTCCTTCAAGATGGTATTGATTACTACAACAAGATAATCGGTGGAGAAACT

CTCAAAAATGGCGAAAAACTAATAGGTCTCAATGAACTAATAAATCAATATAGGC

AGAATAATAAGGATCAGAAAATCCCATTTTTCAAACTTCTTGATAAACAAATTTT

GAGTGAAAAGATATTATTTTTGGATGAAATAAAAAATGACACAGAACTGATCGAG

GCGCTGAGTCAGTTCGCAAAAACAGCCGAAGAAAAAACAAAAATTGTCAAAAAGC

TTTTTGCCGATTTTGTAGAAAATAATTCCAAATACGATCTTGCACAGATTTATAT

TTCCCAAGAAGCATTCAATACTATATCAAACAAGTGGACAAGCGAAACTGAGACG

TTCGCTAAATATCTATTCGAAGCAATGAAGAGTGGAAAACTTGCAAAGTATGAGA

AAAAAGATAATAGCTATAAATTTCCTGATTTTATTGCCCTTTCACAGATGAAGAG

TGCTTTATTAAGTATCAGCCTTGAGGGACATTTTTGGAAAGAGAAATACTACAAA

ATTTCAAAATTCCAAGAGAAGACCAATTGGGAGCAGTTTCTTGCAATTTTTCTAT

ACGAGTTTAACTCTCTTTTCAGCGACAAAATAAATACAAAAGATGGAGAAACAAA

GCAAGTTGGATACTATCTATTTGCCAAAGACCTGCATAATCTTATCTTAAGTGAG

CAGATTGATATTCCAAAAGATTCAAAAGTCACAATAAAAGATTTTGCCGATTCTG

TACTCACAATCTACCAAATGGCAAAATATTTTGCGGTAGAAAAAAAACGAGCGTG

GCTTGCCGAGTATGAACTAGATTCATTTTATACCCAGCCAGACACAGGCTATTTA

CAGTTTTATGATAACGCCTACGAGGATATTGTGCAGGTATACAACAAGCTTCGAA

ACTATCTGACCAAAAAGCCATATAGCGAGGAGAAATGGAAGTTGAATTTTGAAAA

TTCTACGCTGGCAAATGGATGGGATAAGAACAAAGAATCTGATAATTCAGCAGTT

ATTCTACAAAAAGGTGGAAAATATTATTTGGGACTGATTACTAAAGGACACAACA

AAATTTTTGATGACCGTTTTCAAGAAAAATTTATTGTGGGAATTGAAGGTGGAAA

ATATGAAAAAATAGTCTATAAATTTTTCCCCGACCAGGCAAAAATGTTTCCCAAA

GTGTGCTTTTCTGCAAAAGGACTCGAATTTTTTAGACCGTCTGAAGAAATTTTAA

GAATTTATAACAATGCAGAGTTTAAAAAAGGAGAAACTTATTCAATAGATAGTAT

GCAGAAGTTGATTGATTTTTATAAAGATTGCTTGACTAAATATGAAGGCTGGGCA

TGTTATACCTTTCGGCATCTAAAACCCACAGAAGAATACCAAAACAATATTGGAG

AGTTTTTTCGAGATGTTGCAGAGGACGGATACAGGATTGATTTTCAAGGCATTTC

AGATCAATATATTCATGAAAAAAACGAGAAAGGCGAACTTCACCTTTTTGAAATC

CACAATAAAGATTGGAATTTGGATAAGGCACGAGACGGAAAGTCAAAAACAACAC

AAAAAAACCTTCATACACTCTATTTCGAATCGCTCTTTTCAAACGATAATGTTGT

TCAAAACTTTCCAATAAAACTCAATGGTCAAGCTGAAATTTTTTATAGACCGAAA

ACGGAAAAAGACAAATTAGAATCAAAAAAAGATAAGAAAGGGAATAAAGTGATTG

ACCATAAACGCTATAGTGAGAATAAGATTTTTTTTCATGTTCCTCTCACACTAAA

CCGCACTAAAAATGACTCATATCGCTTTAATGCTCAAATCAACAACTTTCTCGCA

AATAATAAAGATATCAACATCATCGGTGTAGATAGGGGAGAAAAGCATTTAGTCT

ATTATTCGGTGATTACACAAGCTAGTGACATCTTAGAAAGTGGCTCACTAAATGA

GCTAAATGGCGTGAATTATGCTGAAAAACTGGGAAAAAAGGCAGAAAATCGAGAA

CAAGCACGCAGAGACTGGCAAGACGTACAAGGGATCAAAGACCTCAAGAAAGGAT

ATATTTCACAGGTGGTGCGAAAGCTTGCTGATTTAGCAATTAAACACAATGCCAT

TATCATTCTTGAAGATTTGAATATGAGATTTAAACAAGTTCGGGGCGGTATCGAA

AAATCCATTTATCAACAGTTAGAAAAAGCACTGATAGATAAATTAAGCTTTCTTG

TAGACAAAGGTGAAAAAAATCCCGAGCAAGCAGGACATCTTCTGAAAGCATATCA

GCTTTCGGCCCCATTTGAGACATTTCAAAAAATGGGCAAACAGACGGGTATAATC

TTTTATACACAAGCTTCGTATACCTCAAAAAGTGACCCTGTAACAGGTTGGCGAC

CACACCTGTATCTCAAATATTTCAGTGCCAAAAAAGCAAAAGACGATATTGCAAA

GTTTACAAAAATAGAATTTGTAAACGATAGGTTTGAGCTTACCTATGATATAAAG

GACTTTCAGCAAGCAAAAGAATATCCAAATAAAACTGTTTGGAAAGTTTGCTCAA

ATGTAGAGAGATTCAGGTGGGACAAAAACCTCAATCAAAACAAAGGCGGATATAC

TCACTACACAAATATAACTGAGAATATCCAAGAGCTTTTTACAAAATATGGAATT

GATATCACAAAAGATTTGCTCACACAGATTTCTACAATTGATGAAAAACAAAATA

CCTCATTTTTTAGAGATTTTATTTTTTATTTCAACCTTATTTGCCAAATCAGAAA

TACCGATGATTCTGAGATTGCTAAAAAGAATGGGAAAGATGATTTTATACTGTCA

CCTGTTGAGCCGTTTTTCGATAGCCGAAAAGACAATGGAAATAAACTTCCTGAGA

ATGGAGATGATAACGGCGCGTATAACATAGCAAGAAAAGGGATTGTCATACTCAA

CAAAATCTCACAATATTCAGAGAAAAACGAAAATTGCGAGAAAATGAAATGGGGG

GATTTGTATGTATCAAACATTGACTGGGACAATTTTGTAACCCAAGCTAATGCAC

GGCATTAA

SEQ
ATGATTATCTTATATATTAGTACCTCGAATATGAACATGGAAGGAGTATTTATGG

ID
AAAATTTTAAAAACTTGTATCCAATAAACAAAACACTTCGATTTGAATTAAGACC

NO:
CTATGGAAAAACATTGGAAAATTTTAAAAAATCCGGACTTTTAGAAAAAGATGCC

31
TTTAAGGCAAATAGTAGACGAAGTATGCAAGCTATAATCGATGAAAAATTCAAAG

AGACTATCGAAGAACGCTTAAAGTACACTGAATTCAGTGAATGTGATCTTGGAAA

CATGACATCAAAAGATAAAAAAATAACTGATAAAGCAGCTACAAATTTAAAAAAG

CAAGTTATCTTATCTTTTGACGATGAAATATTTAATAATTACCTAAAACCTGATA

AAAATATTGACGCATTATTTAAAAATGATCCTTCAAATCCTGTAATCTCTACATT

TAAAGGTTTTACGACATATTTTGTGAATTTTTTTGAAATTCGAAAACATATTTTC

AAGGGAGAATCATCAGGCTCAATGGCATACCGAATTATAGATGAAAACCTGACAA

CATACTTGAATAATATTGAAAAAATAAAAAAACTGCCAGAAGAATTAAAATCACA

GCTAGAAGGCATTGATCAGATTGATAAACTTAATAATTATAATGAGTTCATTACA

CAGTCAGGTATAACACACTATAATGAAATCATCGGCGGTATATCAAAATCAGAGA

ATGTCAAAATACAGGGAATTAATGAAGGAATTAATCTATACTGTCAGAAGAACAA

AGTTAAACTTCCTCGACTGACTCCGCTATACAAAATGATATTATCAGACAGAGTT

TCCAACTCTTTTGTATTAGACACTATTGAAAATGACACAGAATTAATTGAAATGA

TAAGTGATTTGATTAATAAGACTGAGATTTCGCAAGATGTTATAATGTCAGATAT

TCAAAATATTTTCATAAAATACAAACAACTTGGTAATTTGCCGGGTATCTCATAT

TCTTCAATAGTTAATGCTATTTGCTCGGATTATGACAACAATTTCGGAGATGGGA

AGCGAAAAAAATCTTACGAAAATGATCGCAAAAAGCATTTGGAGACTAATGTATA

CTCCATAAATTATATTTCTGAATTGCTTACAGATACCGATGTTTCATCAAATATC

AAGATGAGATATAAAGAGCTTGAGCAAAATTATCAGGTTTGCAAAGAAAATTTTA

ATGCCACAAACTGGATGAATATTAAAAATATAAAACAATCTGAAAAAACAAACCT

TATTAAAGATTTGTTAGATATACTTAAATCGATTCAACGTTTCTATGATTTGTTT

GATATTGTTGACGAAGATAAAAATCCAAGTGCTGAATTTTATACCTGGTTATCAA

AAAATGCTGAAAAGCTTGACTTTGAATTCAATTCTGTATATAACAAGTCACGAAA

CTATCTCACCAGGAAACAATACTCTGATAAAAAAATCAAGCTGAATTTTGATTCT

CCAACATTGGCCAAAGGGTGGGATGCTAACAAAGAAATAGATAACTCCACGATTA

TAATGCGTAAATTTAATAATGACAGAGGCGATTATGATTACTTCCTTGGCATATG

GAATAAATCCACACCTGCAAATGAAAAAATAATCCCACTGGAGGATAATGGATTA

TTCGAAAAAATGCAATATAAGCTGTATCCAGATCCTAGTAAGATGTTACCGAAAC

AATTTCTATCAAAAATATGGAAGGCAAAGCATCCTACGACACCTGAATTTGATAA

AAAATATAAAGAGGGAAGACATAAAAAAGGTCCTGATTTCGAAAAAGAATTCCTG

CATGAATTGATTGATTGCTTCAAACATGGTCTTGTTAATCACGATGAAAAATATC

AGGATGTTTTTGGCTTCAATCTCCGTAACACTGAAGATTATAATTCATATACAGA

GTTTCTCGAAGATGTGGAAAGATGCAATTACAATCTTTCATTTAACAAAATTGCT

GATACTTCAAACCTTATTAATGATGGGAAATTGTATGTATTTCAGATATGGTCAA

AAGACTTTTCTATTGATTCAAAAGGTACTAAAAACTTGAATACAATCTATTTTGA

ATCACTATTTTCAGAAGAAAACATGATAGAAAAAATGTTCAAGCTTTCTGGAGAG

GCTGAGATATTCTATCGACCAGCATCGTTGAATTATTGTGAAGATATCATAAAAA

AAGGTCATCACCATGCAGAATTAAAAGATAAGTTTGACTATCCTATAATAAAAGA

TAAGCGATATTCACAAGATAAGTTTTTCTTTCATGTGCCAATGGTTATAAATTAT

AAATCTGAGAAACTGAATTCCAAAAGCCTTAACAACCGAACAAATGAAAACCTGG

GACAGTTTACACATATTATAGGTATAGACAGGGGCGAGCGGCACTTGATTTATTT

AACTGTTGTTGATGTTTCCACTGGTGAAATCGTTGAACAGAAACATCTGGACGAA

ATTATCAATACTGATACCAAGGGAGTTGAACACAAAACCCATTATTTGAATAAAT

TGGAAGAAAAATCTAAAACAAGAGATAACGAGCGTAAATCATGGGAAGCTATTGA

AACTATCAAAGAATTAAAAGAAGGCTATATTTCTCATGTAATTAATGAAATACAA

AAGCTGCAAGAAAAATATAATGCCTTAATCGTAATGGAAAATCTTAACTATGGGT

TCAAAAACTCACGAATCAAAGTTGAAAAACAGGTTTATCAAAAATTCGAGACAGC

ATTGATTAAAAAGTTCAATTATATTATTGATAAAAAAGATCCAGAAACCTATATA

CATGGTTACCAGCTTACAAATCCTATTACCACTCTGGATAAGATTGGAAATCAAT

CTGGAATAGTGCTGTATATTCCTGCGTGGAATACTTCTAAGATAGATCCCGTCAC

AGGATTTGTAAACCTTCTGTACGCAGATGATTTGAAGTATAAAAATCAGGAGCAG

GCCAAATCATTCATTCAGAAAATAGACAACATATATTTTGAAAATGGAGAGTTTA

AATTTGATATTGATTTTTCCAAATGGAATAATCGCTACTCAATAAGTAAAACTAA

ATGGACGTTAACAAGTTATGGGACTCGCATCCAGACATTTAGAAATCCCCAGAAA

AACAATAAGTGGGATTCTGCTGAATATGATTTGACAGAAGAGTTTAAATTAATTT

TAAATATAGACGGAACGTTAAAGTCACAGGACGTAGAAACATACAAAAAATTCAT

GTCTTTATTTAAACTAATGCTACAGCTTCGAAACTCTGTTACAGGAACCGACATT

GATTATATGATCTCTCCTGTCACTGATAAAACAGGAACACATTTCGATTCAAGAG

AAAATATTAAAAATCTTCCTGCCGATGCAGATGCCAATGGTGCCTACAACATTGC

GCGCAAAGGAATAATGGCTATTGAAAATATAATGAACGGTATAAGCGATCCACTA

AAAATAAGCAACGAAGACTATTTAAAGTATATTCAGAATCAACAGGAATAA

SEQ
ATGACCCAATTTGAAGGTTTTACCAATTTATACCAAGTTTCGAAGACCCTTCGTT

ID
TTGAACTGATTCCCCAAGGAAAAACACTCAAACATATCCAGGAGCAAGGGTTCAT

NO:
TGAGGAGGATAAAGCTCGCAATGACCATTACAAAGAGTTAAAACCAATCATTGAC

32
CGCATCTATAAGACTTATGCTGATCAATGTCTCCAACTGGTACAGCTTGACTGGG

AGAATCTATCTGCAGCCATAGACTCCTATCGTAAGGAAAAAACCGAAGAAACACG

AAATGCGCTGATTGAGGAGCAAGCAACATATAGAAATGCGATTCATGACTACTTT

ATAGGTCGGACGGATAATCTGACAGATGCCATAAATAAGCGCCATGCTGAAATCT

ATAAAGGACTTTTTAAAGCTGAACTTTTCAATGGAAAAGTTTTAAAGCAATTAGG

GACCGTAACCACGACAGAACATGAAAATGCTCTACTCCGTTCGTTTGACAAATTT

ACGACCTATTTTTCCGGCTTTTATGAAAACCGAAAAAATGTCTTTAGCGCTGAAG

ATATCAGCACGGCAATTCCCCATCGAATCGTCCAGGACAATTTCCCTAAATTTAA

GGAAAACTGCCATATTTTTACAAGATTGATAACCGCAGTTCCTTCTTTGCGGGAG

CATTTTGAAAATGTCAAAAAGGCCATTGGAATCTTTGTTAGTACGTCTATTGAAG

AAGTCTTTTCCTTTCCCTTTTATAATCAACTTCTAACCCAAACGCAAATTGATCT

TTATAATCAACTTCTCGGCGGCATATCTAGGGAAGCAGGCACAGAAAAAATCAAG

GGACTTAATGAAGTTCTCAATCTGGCTATCCAAAAAAATGATGAAACAGCCCATA

TAATCGCGTCCCTGCCGCATCGTTTTATTCCTCTTTTTAAACAAATTCTTTCCGA

TCGAAATACGTTATCCTTTATTTTGGAAGAATTCAAAAGCGATGAGGAAGTCATC

CAATCCTTCTGCAAATATAAAACCCTCTTGAGAAACGAAAATGTACTGGAGACTG

CAGAAGCCCTTTTCAATGAATTAAATTCCATTGATTTGACTCATATCTTTATTTC

CCATAAAAAGTTAGAAACCATCTCTTCAGCGCTTTGTGACCATTGGGATACCTTG

CGCAATGCACTTTACGAAAGACGGATTTCTGAACTCACTGGCAAAATAACAAAAA

GTGCCAAAGAAAAAGTTCAAAGGTCATTAAAACATGAGGATATAAATCTCCAAGA

AATTATTTCTGCTGCAGGAAAAGAACTATCAGAAGCATTCAAACAAAAAACAAGT

GAAATTCTTTCCCATGCCCATGCTGCACTTGACCAGCCTCTTCCCACAACATTAA

AAAAACAGGAAGAAAAAGAAATCCTCAAATCACAGCTCGATTCGCTTTTAGGCCT

TTATCATCTTCTTGATTGGTTTGCTGTCGATGAAAGCAATGAAGTCGACCCAGAA

TTCTCAGCACGGCTGACAGGCATTAAACTAGAAATGGAACCAAGCCTTTCGTTTT

ATAATAAAGCAAGAAATTATGCGACAAAAAAGCCCTATTCGGTGGAAAAATTTAA

ATTGAATTTTCAAATGCCAACCCTTGCCTCTGGTTGGGATGTCAATAAAGAAAAA

AATAATGGAGCTATTTTATTCGTAAAAAATGGTCTCTATTACCTTGGTATCATGC

CTAAACAGAAGGGGCGCTATAAAGCCCTGTCTTTTGAGCCGACAGAAAAAACATC

AGAAGGATTCGATAAGATGTACTATGACTACTTCCCAGATGCCGCAAAAATGATT

CCTAAGTGTTCCACTCAGCTAAAGGCTGTAACCGCTCATTTTCAAACTCATACCA

CCCCCATTCTTCTCTCAAATAATTTCATTGAACCTCTTGAAATCACAAAAGAAAT

TTATGACCTGAACAATCCTGAAAAGGAGCCTAAAAAGTTTCAAACGGCTTATGCA

AAGAAGACAGGCGATCAAAAAGGCTATAGAGAAGCGCTTTGCAAATGGATTGACT

TTACGCGGGATTTTCTCTCTAAATATACGAAAACAACTTCAATCGATTTATCTTC

ACTCCGCCCTTCTTCGCAATATAAAGATTTAGGGGAATATTACGCCGAACTGAAT

CCGCTTCTCTATCATATCTCCTTCCAACGAATTGCTGAAAAGGAAATCATGGATG

CTGTAGAAACGGGAAAATTGTATCTGTTCCAAATCTACAATAAGGATTTTGCGAA

GGGCCATCACGGGAAACCAAATCTCCACACCCTGTATTGGACAGGTCTCTTCAGT

CCTGAAAACCTTGCGAAAACCAGCATCAAACTTAATGGTCAAGCAGAATTGTTCT

ATCGACCTAAAAGCCGCATGAAGCGGATGGCCCATCGTCTTGGGGAAAAAATGCT

GAACAAAAAACTAAAGGACCAGAAGACACCGATTCCAGATACCCTCTACCAAGAA

CTGTACGATTATGTCAACCACCGGCTAAGCCATGATCTTTCCGATGAAGCAAGGG

CCCTGCTTCCAAATGTTATCACCAAAGAAGTCTCCCATGAAATTATAAAGGATCG

GCGGTTTACTTCCGATAAATTTTTCTTCCATGTTCCCATTACACTGAATTATCAA

GCAGCCAATAGTCCCAGTAAATTCAACCAGCGTGTCAATGCCTACCTTAAGGAGC

ATCCGGAAACGCCCATCATTGGTATCGATCGTGGAGAACGCAATCTAATCTATAT

TACCGTCATTGACAGTACTGGGAAAATTTTGGAGCAGCGTTCCCTGAATACCATC

CAGCAATTTGACTACCAAAAAAAATTGGACAACAGGGAAAAAGAGCGTGTTGCCG

CCCGTCAAGCCTGGTCCGTCGTCGGAACGATCAAAGACCTTAAACAAGGCTACTT

GTCACAGGTCATCCATGAAATTGTAGACCTGATGATTCATTACCAAGCTGTTGTC

GTCCTTGAAAACCTCAACTTCGGATTTAAATCAAAACGGACAGGCATTGCCGAAA

AAGCAGTCTACCAACAATTTGAAAAGATGCTAATAGATAAACTCAACTGTTTGGT

TCTCAAAGATTATCCTGCTGAGAAAGTGGGAGGCGTCTTAAACCCGTATCAACTT

ACAGATCAGTTCACGAGCTTTGCAAAAATGGGCACGCAAAGCGGCTTCCTTTTCT

ATGTACCGGCCCCTTATACCTCAAAGATTGATCCCCTGACTGGTTTTGTCGATCC

CTTTGTATGGAAGACCATTAAAAATCATGAAAGTCGGAAGCATTTCCTAGAAGGA

TTTGATTTCCTGCATTATGATGTCAAAACAGGTGATTTTATCCTCCATTTTAAAA

TGAATCGGAATCTCTCTTTCCAGAGAGGGCTTCCTGGCTTCATGCCAGCTTGGGA

TATTGTTTTCGAAAAGAATGAAACCCAATTTGATGCAAAAGGGACGCCCTTCATT

GCAGGAAAACGAATTGTTCCTGTAATCGAAAATCATCGTTTTACGGGTCGTTACA

GAGACCTCTATCCCGCTAATGAACTCATTGCCCTTCTGGAAGAAAAAGGCATTGT

CTTTAGAGACGGAAGTAATATATTACCCAAACTTTTAGAAAATGATGATTCTCAT

GCAATTGATACGATGGTCGCCTTGATTCGCAGTGTACTCCAAATGAGAAACAGCA

ATGCCGCAACGGGGGAAGACTACATCAACTCTCCCGTTAGGGATCTGAACGGGGT

GTGTTTCGACAGTCGATTCCAAAATCCAGAATGGCCAATGGATGCGGATGCCAAC

GGAGCTTATCATATTGCCTTAAAAGGGCAGCTTCTTCTGAACCACCTCAAAGAAA

GCAAAGATCTGAAATTACAAAACGGCATCAGCAACCAAGATTGGCTGGCCTACAT

TCAGGAACTGAGAAACTGA

SEQ
ATGGCCGTCAAATCCATCAAAGTGAAACTTCGTCTCGACGATATGCCGGAGATTC

ID
GGGCCGGTCTATGGAAACTTCATAAGGAAGTCAATGCGGGGGTTCGATATTACAC

NO:
GGAATGGCTCAGTCTTCTCCGTCAAGAGAACTTGTATCGAAGAAGTCCGAATGGG

33
GACGGAGAGCAAGAATGTGATAAGACTGCAGAAGAATGCAAAGCCGAATTGTTGG

AGCGGCTGCGCGCGCGTCAAGTGGAGAATGGACACCGTGGTCCGGCGGGATCGGA

CGATGAATTGCTGCAGTTGGCGCGTCAACTCTATGAGTTGTTGGTTCCGCAGGCG

ATAGGTGCGAAAGGCGACGCGCAGCAAATTGCCCGCAAATTTTTGAGCCCCTTGG

CCGACAAGGACGCAGTTGGTGGGCTTGGAATCGCGAAGGCGGGGAACAAACCGCG

GTGGGTTCGCATGCGCGAAGCGGGGGAACCAGGCTGGGAAGAGGAGAAGGAGAAG

GCTGAGACGAGGAAATCTGCGGATCGGACTGCGGATGTTTTGCGCGCGCTCGCGG

ATTTTGGGTTAAAGCCACTGATGCGCGTATACACCGATTCTGAGATGTCATCGGT

GGAGTGGAAACCGCTTCGGAAGGGACAAGCCGTTCGGACGTGGGATAGGGACATG

TTCCAACAAGCTATCGAACGGATGATGTCGTGGGAGTCGTGGAATCAGCGCGTTG

GGCAAGAGTACGCGAAACTCGTAGAACAAAAAAATCGATTTGAGCAGAAGAATTT

CGTCGGCCAGGAACATCTGGTCCATCTCGTCAATCAGTTGCAACAAGATATGAAA

GAAGCATCGCCCGGACTCGAATCGAAAGAGCAAACCGCGCACTATGTGACGGGAC

GGGCATTGCGCGGATCGGACAAGGTATTTGAGAAGTGGGGGAAACTCGCCCCCGA

TGCACCTTTCGATTTGTACGACGCCGAAATCAAGAATGTGCAGAGACGTAACACG

AGACGATTCGGATCACATGACTTGTTCGCAAAATTGGCAGAGCCAGAGTATCAGG

CCCTGTGGCGCGAAGATGCTTCGTTTCTCACGCGTTACGCGGTGTACAACAGCAT

CCTTCGCAAACTGAATCACGCCAAAATGTTCGCGACGTTTACTTTGCCGGATGCA

ACGGCGCACCCGATTTGGACTCGCTTCGATAAATTGGGTGGGAATTTGCACCAGT

ACACCTTTTTGTTCAACGAATTTGGAGAACGCAGGCACGCGATTCGTTTTCACAA

GCTATTGAAAGTCGAGAATGGTGTCGCAAGAGAAGTTGATGATGTCACCGTGCCC

ATTTCAATGTCAGAGCAATTGGATAATCTGCTTCCCAGAGATCCCAATGAACCGA

TTGCGCTATATTTTCGAGATTACGGAGCCGAACAGCATTTCACAGGTGAATTTGG

TGGCGCGAAGATCCAGTGCCGCCGGGATCAGCTGGCTCATATGCACCGACGCAGA

GGGGCGAGGGATGTTTATCTCAATGTCAGCGTACGTGTGCAGAGTCAGTCTGAGG

CGCGGGGAGAACGTCGCCCGCCGTATGCGGCAGTATTTCGTCTGGTCGGGGACAA

CCATCGCGCGTTTGTCCATTTCGATAAACTATCGGATTATCTTGCGGAACATCCG

GATGATGGGAAGCTCGGGTCGGAGGGGTTGCTTTCCGGGCTGCGGGTGATGAGTG

TCGATCTCGGCCTTCGCACATCTGCATCGATTTCCGTTTTTCGCGTTGCCCGGAA

GGACGAGTTGAAGCCGAACTCAAAAGGTCGTGTACCGTTTTTCTTTCCGATAAAA

GGGAATGACAATCTCGTCGCGGTTCATGAGCGATCACAACTCTTGAAGCTGCCTG

GCGAAACGGAGTCGAAGGACCTGCGTGCTATCCGAGAAGAACGCCAACGGACATT

GCGGCAGTTGCGGACGCAACTGGCGTATTTGCGGCTGCTCGTGCGGTGTGGGTCG

GAAGATGTGGGGCGGCGTGAACGGAGTTGGGCAAAGCTTATCGAGCAGCCGGTGG

ATGCGGCCAATCACATGACACCGGATTGGCGCGAGGCTTTTGAAAACGAACTTCA

GAAGCTTAAGTCACTCCATGGTATCTGTAGCGACAAGGAATGGATGGATGCTGTC

TACGAGAGCGTTCGCCGCGTGTGGCGTCACATGGGCAAACAGGTTCGCGATTGGC

GAAAGGACGTACGAAGCGGAGAGCGGCCCAAGATTCGCGGCTATGCGAAAGACGT

GGTCGGTGGAAACTCGATTGAGCAAATCGAGTATCTGGAACGTCAGTACAAGTTC

CTCAAGAGTTGGAGCTTCTTTGGTAAGGTGTCGGGACAAGTGATTCGTGCGGAGA

AGGGATCTCGTTTTGCGATCACGCTGCGCGAACACATTGATCACGCGAAGGAAGA

TCGGCTGAAGAAATTGGCGGATCGCATCATTATGGAGGCTCTCGGCTATGTGTAC

GCGTTGGATGAGCGCGGCAAAGGAAAGTGGGTTGCGAAGTATCCGCCGTGCCAGC

TCATCCTGCTGGAGGAATTGAGCGAGTACCAGTTCAATAACGACAGGCCTCCGAG

CGAAAACAACCAGTTGATGCAATGGAGTCATCGCGGCGTGTTCCAGGAGTTGATA

AATCAGGCCCAAGTCCATGATTTACTCGTTGGGACGATGTATGCAGCGTTCTCGT

CGCGATTCGACGCGCGAACTGGGGCACCGGGTATCCGCTGTCGCCGGGTTCCGGC

GCGTTGCACCCAGGAGCACAATCCAGAACCATTTCCTTGGTGGCTGAACAAGTTT

GTGGTGGAACATACGTTGGATGCTTGTCCCCTACGCGCAGACGACCTCATCCCAA

CGGGTGAAGGAGAGATTTTTGTCTCGCCGTTCAGCGCGGAGGAGGGGGACTTTCA

TCAGATTCACGCCGACCTGAATGCGGCGCAAAATCTGCAGCAGCGACTCTGGTCT

GATTTTGATATCAGTCAAATTCGGTTGCGGTGTGATTGGGGTGAAGTGGACGGTG

AACTCGTTCTGATCCCAAGGCTTACAGGAAAACGAACGGCGGATTCATATAGCAA

CAAGGTGTTTTATACCAATACAGGTGTCACCTATTATGAGCGAGAGCGGGGGAAG

AAGCGGAGAAAGGTTTTCGCGCAAGAGAAATTGTCGGAGGAAGAGGCGGAGTTGC

TCGTGGAAGCAGACGAGGCGAGGGAGAAATCGGTCGTTTTGATGCGTGATCCGTC

TGGCATCATCAATCGGGGAAATTGGACCAGGCAAAAGGAATTTTGGTCGATGGTG

AACCAGCGGATCGAAGGATACTTGGTCAAGCAGATTCGCTCGCGCGTTCCATTAC

AAGATAGTGCGTGTGAAAACACGGGGGATATTTAA

SEQ
ATGGCGACACGCAGTTTTATTTTAAAAATTGAACCAAATGAAGAAGTTAAAAAGG

ID
GATTATGGAAGACGCATGAGGTATTGAATCATGGAATTGCCTACTACATGAATAT

NO:
TCTGAAACTAATTAGACAGGAAGCTATTTATGAACATCATGAACAAGATCCTAAA

34
AATCCGAAAAAAGTTTCAAAAGCAGAAATACAAGCCGAGTTATGGGATTTTGTTT

TAAAAATGCAAAAATGTAATAGTTTTACACATGAAGTTGACAAAGATGTTGTTTT

TAACATCCTGCGTGAACTATATGAAGAGTTGGTCCCTAGTTCAGTCGAGAAAAAG

GGTGAAGCCAATCAATTATCGAATAAGTTTCTGTACCCGCTAGTTGATCCGAACA

GTCAAAGTGGGAAAGGGACGGCATCATCCGGACGTAAACCTCGGTGGTATAATTT

AAAAATAGCAGGCGACCCATCGTGGGAGGAAGAAAAGAAAAAATGGGAAGAGGAT

AAAAAGAAAGATCCCCTTGCTAAAATCTTAGGTAAGTTAGCAGAATATGGGCTTA

TTCCGCTATTTATTCCATTTACTGACAGCAACGAACCAATTGTAAAAGAAATTAA

ATGGATGGAAAAAAGTCGTAATCAAAGTGTCCGGCGACTTGATAAGGATATGTTT

ATCCAAGCATTAGAGCGTTTTCTTTCATGGGAAAGCTGGAACCTTAAAGTAAAGG

AAGAGTATGAAAAAGTTGAAAAGGAACACAAAACACTAGAGGAAAGGATAAAAGA

GGACATTCAAGCATTTAAATCCCTTGAACAATATGAAAAAGAACGGCAGGAGCAA

CTTCTTAGAGATACATTGAATACAAATGAATACCGATTAAGCAAAAGAGGATTAC

GTGGTTGGCGTGAAATTATCCAAAAATGGCTAAAGATGGATGAAAATGAACCATC

AGAAAAATATTTAGAAGTATTTAAAGATTATCAACGGAAACATCCACGAGAAGCC

GGGGACTATTCTGTCTATGAATTTTTAAGCAAGAAAGAAAATCATTTTATTTGGC

GAAATCATCCTGAATATCCTTATTTGTATGCTACATTTTGTGAAATTGACAAAAA

AAAGAAAGACGCTAAGCAACAGGCAACTTTTACTTTGGCTGACCCGATTAACCAT

CCGTTATGGGTACGATTTGAAGAAAGAAGCGGTTCGAACTTAAACAAATATCGAA

TTTTAACAGAGCAATTACACACTGAAAAGTTAAAAAAGAAATTAACAGTTCAACT

TGATCGTTTAATTTATCCAACTGAATCCGGCGGTTGGGAGGAAAAAGGTAAAGTA

GATATCGTTTTGTTGCCGTCAAGACAATTTTATAATCAAATCTTCCTTGATATAG

AAGAAAAGGGGAAACATGCTTTTACTTATAAGGATGAAAGTATTAAATTCCCCCT

TAAAGGTACACTTGGTGGTGCAAGAGTGCAGTTTGACCGTGACCATTTGCGGAGA

TATCCGCATAAAGTAGAATCAGGAAATGTTGGACGGATTTATTTTAACATGACAG

TAAATATTGAACCAACTGAGAGCCCTGTTAGTAAGTCTTTGAAAATACATAGGGA

CGATTTCCCCAAGTTCGTTAATTTTAAACCGAAAGAGCTCACCGAATGGATAAAA

GATAGTAAAGGGAAAAAATTAAAAAGTGGTATAGAATCCCTTGAAATTGGTCTAC

GGGTGATGAGTATCGACTTAGGTCAACGTCAAGCGGCTGCTGCATCGATTTTTGA

AGTAGTTGATCAGAAACCGGATATTGAAGGGAAGTTATTTTTTCCAATCAAAGGA

ACTGAGCTTTATGCTGTTCACCGGGCAAGTTTTAACATTAAATTACCGGGTGAAA

CATTAGTAAAATCACGGGAAGTATTGCGGAAAGCTCGGGAGGACAACTTAAAATT

AATGAATCAAAAGTTAAACTTTCTAAGAAATGTTCTACATTTCCAACAGTTTGAA

GATATCACAGAAAGAGAGAAGCGTGTAACTAAATGGATTTCTAGACAAGAAAATA

GTGATGTTCCTCTTGTATATCAAGATGAGCTAATTCAAATTCGTGAATTAATGTA

TAAACCCTATAAAGATTGGGTTGCCTTTTTAAAACAACTCCATAAACGGCTAGAA

GTCGAGATTGGCAAAGAGGTTAAGCATTGGCGAAAATCATTAAGTGACGGGAGAA

AAGGTCTTTACGGAATCTCCCTAAAAAATATTGATGAAATTGATCGAACAAGGAA

ATTCCTTTTAAGATGGAGCTTACGTCCAACAGAACCTGGGGAAGTAAGACGCTTG

GAACCAGGACAGCGTTTTGCGATTGATCAATTAAACCACCTAAATGCATTAAAAG

AAGATCGATTAAAAAAGATGGCAAATACGATTATCATGCATGCCTTAGGTTACTG

TTATGATGTAAGAAAGAAAAAGTGGCAGGCAAAAAATCCAGCATGTCAAATTATT

TTATTTGAAGATTTATCTAACTACAATCCTTACGAGGAAAGGTCCCGTTTTGAAA

ACTCAAAACTGATGAAGTGGTCACGGAGAGAAATTCCACGACAAGTCGCCTTACA

AGGTGAAATTTACGGATTACAAGTTGGGGAAGTAGGTGCCCAATTCAGTTCAAGA

TTCCATGCGAAAACCGGGTCGCCGGGAATTCGTTGCAGTGTTGTAACGAAAGAAA

AATTGCAGGATAATCGCTTTTTTAAAAATTTACAAAGAGAAGGACGACTTACTCT

TGATAAAATCGCAGTTTTAAAAGAAGGAGACTTATATCCAGATAAAGGTGGAGAA

AAGTTTATTTCTTTATCAAAGGATCGAAAGTTGGTAACTACGCATGCTGATATTA

ACGCGGCCCAAAATTTACAGAAGCGTTTTTGGACAAGAACACATGGATTTTATAA

AGTTTACTGCAAAGCCTATCAGGTTGATGGACAAACTGTTTATATTCCGGAGAGC

AAGGACCAAAAACAAAAAATAATTGAAGAATTTGGGGAAGGCTATTTTATTTTAA

AAGATGGTGTATATGAATGGGGTAATGCGGGGAAACTAAAAATTAAAAAAGGTTC

CTCTAAACAATCATCGAGTGAATTAGTAGATTCGGACATACTGAAAGATTCATTT

GATTTAGCAAGTGAACTTAAGGGAGAGAAACTCATGTTATATCGAGATCCGAGTG

GAAACGTATTTCCTTCCGACAAGTGGATGGCAGCAGGAGTATTTTTTGGCAAATT

AGAAAGAATATTGATTTCTAAGTTAACAAATCAATACTCAATATCAACAATAGAA

GATGATTCTTCAAAACAATCAATGTAA

SEQ
ATGCCCACCCGCACCATCAATCTGAAACTTGTTCTTGGGAAAAATCCTGAAAACG

ID
CAACATTGCGACGCGCCCTATTTTCGACACACCGTTTGGTTAACCAAGCGACGAA

NO:
ACGTATTGAGGAATTCTTGTTGCTGTGTCGTGGAGAAGCCTACAGAACAGTGGAT

35
AATGAGGGGAAGGAAGCCGAGATTCCACGTCATGCAGTCCAAGAAGAAGCTCTTG

CCTTTGCCAAAGCTGCTCAACGCCACAACGGCTGTATATCCACCTATGAAGACCA

AGAGATTCTTGATGTACTGCGGCAACTGTACGAACGTCTTGTTCCTTCGGTCAAC

GAAAACAACGAGGCAGGCGATGCTCAAGCTGCTAACGCCTGGGTCAGTCCGCTCA

TGTCGGCAGAAAGCGAAGGAGGCTTGTCGGTCTACGACAAGGTGCTTGATCCACC

GCCGGTTTGGATGAAGCTTAAAGAAGAAAAGGCTCCAGGATGGGAAGCCGCTTCT

CAAATTTGGATTCAGAGTGATGAGGGACAGTCGTTACTTAATAAGCCAGGTAGCC

CTCCCCGCTGGATTCGAAAACTGCGATCTGGGCAACCGTGGCAAGATGATTTCGT

CAGTGACCAAAAGAAAAAGCAAGATGAGCTGACCAAAGGGAACGCACCACTTATA

AAACAACTCAAAGAAATGGGGTTGTTGCCTCTTGTTAACCCATTTTTTAGACATC

TTCTTGACCCTGAAGGTAAAGGCGTGAGTCCATGGGACCGTCTTGCTGTACGCGC

TGCAGTGGCTCACTTTATCTCCTGGGAAAGTTGGAATCATAGAACACGTGCAGAA

TACAATTCCTTGAAACTACGGCGAGACGAGTTTGAGGCAGCATCCGACGAATTCA

AAGACGATTTTACTTTGCTCCGACAATATGAAGCCAAACGCCATAGTACATTGAA

AAGCATCGCGCTGGCCGACGATTCGAACCCTTACCGGATTGGAGTACGTTCTCTG

CGTGCCTGGAACCGCGTTCGTGAAGAATGGATAGACAAGGGTGCAACAGAAGAAC

AACGCGTGACCATATTGTCAAAGCTTCAAACACAACTTCGGGGAAAATTCGGCGA

TCCCGATCTGTTCAACTGGCTAGCTCAGGATAGGCATGTCCATTTGTGGTCTCCT

CGGGACAGCGTGACACCATTGGTTCGCATCAATGCGGTAGATAAAGTTCTGCGTC

GACGAAAACCGTATGCATTGATGACCTTTGCCCATCCCCGCTTCCACCCTCGATG

GATACTGTACGAGGCTCCAGGAGGAAGCAATCTCCGTCAATATGCATTGGATTGT

ACAGAAAACGCTCTACACATCACGTTGCCTTTGCTTGTCGACGATGCGCACGGAA

CCTGGATTGAAAAAAAGATCAGGGTGCCGCTGGCACCATCCGGACAAATTCAAGA

TTTAACTCTGGAAAAACTTGAGAAGAAAAAAAATCGTTTATACTACCGTTCCGGT

TTTCAGCAGTTTGCCGGCTTGGCTGGCGGAGCTGAGGTTCTTTTCCACAGACCCT

ATATGGAACACGACGAACGCAGCGAGGAGTCTCTTTTGGAACGTCCGGGAGCCGT

TTGGTTCAAATTGACCCTGGATGTGGCAACACAGGCTCCCCCGAACTGGCTTGAT

GGTAAGGGCCGTGTCCGTACACCGCCGGAGGTACATCATTTTAAAACCGCATTGT

CGAATAAAAGCAAACATACACGTACGCTGCAGCCGGGTCTCCGTGTCTTGTCAGT

AGACTTGGGCATGCGAACATTCGCCTCCTGCTCAGTATTTGAACTCATCGAGGGA

AAGCCTGAGACAGGCCGTGCCTTCCCTGTTGCCGATGAGAGATCAATGGACAGCC

CGAATAAACTGTGGGCCAAGCATGAACGTAGTTTTAAACTGACGCTCCCCGGCGA

AACCCCTTCTCGAAAGGAAGAGGAAGAGCGTAGCATAGCAAGAGCGGAAATTTAT

GCACTGAAACGCGACATACAACGCCTCAAAAGCCTACTCCGCTTAGGTGAAGAAG

ATAACGATAACCGTCGTGATGCATTGCTTGAACAGTTCTTTAAAGGATGGGGAGA

AGAAGACGTTGTGCCTGGACAAGCGTTTCCACGCTCTCTTTTCCAAGGGTTGGGA

GCTGCCCCGTTTCGCTCAACTCCAGAGTTATGGCGTCAGCATTGCCAAACATATT

ATGACAAAGCGGAAGCCTGTCTGGCTAAACATATCAGTGATTGGCGCAAGCGAAC

TCGTCCCCGTCCGACATCGCGGGAGATGTGGTACAAAACACGTTCCTATCATGGC

GGCAAGTCCATTTGGATGTTGGAATATCTTGATGCCGTTCGAAAACTGCTTCTCA

GTTGGAGCTTACGTGGTCGTACTTACGGTGCCATTAATCGCCAGGATACAGCCCG

GTTTGGTTCTTTGGCATCACGGCTGCTCCACCATATCAATTCCCTAAAGGAAGAC

CGCATCAAAACAGGAGCCGACTCTATCGTTCAGGCTGCTCGCGGGTATATTCCTC

TCCCTCATGGCAAGGGTTGGGAACAAAGATATGAGCCTTGTCAGCTCATATTATT

TGAAGACCTCGCACGATATCGCTTTCGCGTGGATCGACCTCGTCGAGAGAACAGC

CAACTCATGCAGTGGAACCATCGAGCCATCGTGGCAGAAACAACGATGCAAGCCG

AACTCTACGGACAAATTGTCGAAAATACTGCAGCGGGGTTCAGCAGTCGTTTTCA

CGCGGCGACAGGTGCCCCCGGTGTACGTTGTCGTTTTCTTCTAGAAAGAGACTTT

GATAACGATTTGCCCAAACCGTACCTTCTCAGGGAACTTTCTTGGATGCTCGGCA

ATACAAAAGTCGAGTCTGAAGAAGAAAAGCTTCGATTGCTGTCTGAAAAAATCAG

GCCAGGCAGTCTTGTTCCTTGGGATGGAGGCGAACAGTTCGCTACCCTGCATCCC

AAAAGACAAACACTTTGCGTCATTCATGCCGATATGAATGCTGCCCAAAATTTAC

AACGCCGGTTTTTCGGTCGATGCGGCGAGGCCTTTCGGCTTGTTTGTCAACCCCA

CGGTGACGACGTGTTACGACTCGCATCCACCCCAGGAGCTCGTCTTCTTGGAGCC

CTGCAGCAGCTTGAAAATGGACAAGGAGCTTTCGAGTTGGTTCGAGACATGGGGT

CAACAAGTCAAATGAACCGGTTCGTCATGAAGTCTTTGGGAAAAAAGAAAATAAA

ACCCCTTCAGGACAACAATGGAGACGACGAGCTTGAAGACGTGTTGTCCGTACTC

CCGGAGGAAGACGACACAGGACGTATCACAGTCTTCCGCGATTCATCAGGAATCT

TTTTTCCTTGCAACGTCTGGATACCGGCCAAACAGTTTTGGCCAGCAGTACGCGC

CATGATTTGGAAGGTCATGGCTTCCCATTCTTTGGGGTGA

SEQ
ATGACAAAGTTAAGACACCGACAGAAAAAATTAACACACGACTGGGCTGGCTCCA

ID
AAAAGAGGGAAGTATTAGGCTCAAATGGCAAGCTTCAGAATCCGTTGTTAATGCC

NO:
GGTTAAAAAAGGTCAGGTTACTGAGTTCCGGAAAGCGTTTTCTGCGTATGCTCGC

36
GCAACGAAAGGAGAAATGACTGACGGCCGAAAGAATATGTTTACGCATAGTTTCG

AGCCATTTAAGACAAAGCCCTCGCTTCATCAGTGTGAATTGGCAGATAAAGCATA

TCAATCTTTACATTCGTATCTGCCTGGTTCTCTTGCTCATTTTCTATTATCTGCT

CACGCATTAGGTTTTCGTATTTTTTCAAAATCTGGTGAAGCAACTGCATTCCAGG

CATCCTCTAAAATTGAAGCTTACGAATCAAAATTGGCAAGCGAATTAGCTTGTGT

AGATTTATCTATTCAAAACTTGACTATTTCAACGCTTTTTAATGCGCTTACAACG

TCTGTAAGAGGGAAGGGCGAAGAAACTAGCGCTGACCCCTTAATTGCACGATTTT

ACACCTTACTTACTGGCAAGCCTCTGTCTCGAGACACTCAAGGGCCTGAACGTGA

TTTAGCAGAAGTTATCTCGCGTAAGATAGCTAGTTCTTTTGGCACATGGAAAGAA

ATGACGGCAAACCCTCTTCAGTCATTACAATTTTTTGAAGAGGAACTCCATGCGC

TGGATGCCAATGTCTCGCTCTCACCCGCCTTCGACGTTTTAATTAAAATGAATGA

TTTGCAGGGCGATTTAAAAAATCGAACCATTGTTTTTGATCCTGACGCCCCTGTT

TTTGAATATAACGCAGAAGACCCTGCCGACATAATTATTAAACTTACAGCTCGTT

ACGCTAAAGAAGCTGTCATCAAAAATCAAAACGTAGGAAATTACGTTAAAAACGC

TATTACTACCACAAATGCCAATGGTCTTGGTTGGCTTTTGAACAAAGGTTTGTCG

TTACTCCCTGTCTCGACCGATGACGAATTGCTAGAGTTTATTGGCGTTGAACGAT

CTCATCCCTCATGCCATGCCTTAATTGAATTGATTGCACAATTAGAAGCCCCCGA

GCTCTTTGAGAAGAACGTATTTTCAGATACTCGTTCTGAAGTTCAAGGTATGATT

GATTCAGCTGTTTCTAATCATATTGCTCGTCTTTCCAGCTCTAGAAATAGCTTGT

CAATGGATAGTGAAGAATTAGAACGTTTAATCAAAAGCTTTCAGATACACACACC

TCATTGCTCACTTTTTATTGGCGCCCAATCACTTTCACAGCAGTTAGAATCTTTG

CCTGAAGCCCTTCAATCGGGCGTTAATTCAGCCGATATTTTACTAGGCTCTACTC

AATATATGCTCACCAATTCTTTGGTTGAAGAGTCAATTGCAACTTATCAAAGAAC

ACTTAATCGCATCAATTACTTGTCAGGTGTTGCAGGTCAGATTAACGGCGCAATA

AAGCGAAAAGCGATAGATGGAGAAAAAATTCACTTGCCTGCAGCTTGGTCAGAGT

TGATATCTTTACCATTTATAGGCCAGCCTGTTATAGATGTTGAAAGCGATTTAGC

TCATCTAAAAAATCAATACCAAACACTTTCAAATGAGTTTGATACTCTTATATCT

GCTTTGCAAAAGAATTTTGATTTGAACTTTAATAAAGCGCTCCTTAATCGTACTC

AGCATTTTGAAGCCATGTGTAGAAGCACTAAGAAAAACGCTTTATCCAAACCAGA

GATCGTTTCCTATCGCGACCTGCTTGCTCGATTAACTTCTTGTTTGTATCGAGGC

TCTTTAGTTTTGCGTCGTGCCGGCATTGAAGTGTTAAAAAAACATAAAATATTTG

AGTCAAACAGCGAACTTCGTGAACATGTTCATGAAAGAAAGCATTTCGTGTTTGT

TAGTCCTCTAGATCGCAAAGCCAAGAAACTCCTTCGATTAACTGATTCGCGTCCA

GACTTGTTACATGTTATTGATGAAATATTGCAGCACGATAATCTTGAAAACAAAG

ACCGCGAGTCACTTTGGCTAGTTCGCTCTGGTTATTTGCTTGCAGGACTTCCAGA

TCAACTTTCTTCATCTTTTATTAACTTGCCTATCATTACTCAAAAAGGAGATAGA

CGCCTTATAGACCTGATTCAGTATGATCAAATTAATCGTGATGCTTTTGTTATGT

TAGTGACCTCTGCATTCAAGTCTAATTTGTCTGGTCTGCAGTATCGTGCCAATAA

GCAATCGTTCGTTGTTACTCGCACGCTAAGCCCTTATCTCGGCTCAAAACTTGTC

TACGTACCCAAGGATAAAGATTGGTTAGTTCCTTCTCAAATGTTTGAAGGACGAT

TTGCTGACATTCTTCAATCAGATTATATGGTCTGGAAAGATGCCGGTCGTCTTTG

TGTTATTGATACTGCAAAACACCTTTCTAATATAAAGAAGTCTGTATTTTCATCC

GAAGAAGTTCTCGCTTTTTTAAGAGAACTCCCTCACCGCACATTTATCCAGACCG

AAGTTCGCGGCCTTGGCGTTAATGTCGATGGAATTGCATTTAATAATGGTGATAT

TCCGTCATTAAAAACCTTTTCAAATTGCGTTCAGGTAAAAGTTTCTCGGACTAAT

ACATCCCTAGTTCAAACACTTAATCGTTGGTTTGAAGGAGGAAAAGTTTCTCCTC

CGAGCATTCAATTTGAACGGGCGTATTATAAAAAAGACGATCAAATTCATGAAGA

CGCAGCGAAAAGAAAGATACGATTCCAGATGCCCGCAACTGAGTTGGTTCATGCT

TCTGACGATGCGGGGTGGACACCAAGTTATTTGCTCGGCATTGATCCTGGCGAGT

ATGGAATGGGTCTTTCATTGGTTTCGATTAATAACGGAGAAGTCTTAGATTCAGG

CTTTATTCATATTAATTCTCTGATCAATTTTGCCTCTAAAAAGAGCAACCATCAA

ACTAAGGTTGTTCCGCGTCAGCAGTACAAATCTCCTTATGCAAATTATTTAGAAC

AATCTAAAGATTCTGCTGCTGGTGATATTGCGCATATACTCGATCGACTTATATA

CAAATTAAATGCGTTGCCTGTTTTTGAGGCTCTTTCAGGTAATTCTCAGAGTGCT

GCTGATCAAGTTTGGACGAAAGTCTTATCGTTTTACACTTGGGGTGATAATGACG

CTCAGAATTCTATTAGAAAGCAGCATTGGTTTGGAGCCAGTCATTGGGATATCAA

AGGTATGTTAAGGCAACCCCCTACGGAGAAGAAGCCTAAACCGTATATTGCTTTT

CCTGGCTCTCAGGTTTCTTCGTATGGTAATTCCCAACGTTGCTCTTGCTGCGGTC

GCAATCCTATTGAACAACTTCGAGAAATGGCAAAGGATACCTCTATTAAAGAGCT

AAAAATTCGCAATTCTGAGATACAGCTTTTTGACGGAACCATTAAATTATTTAAT

CCAGACCCATCCACTGTGATAGAGAGAAGGCGACATAATCTTGGTCCATCAAGAA

TTCCTGTTGCTGACCGTACTTTCAAAAACATCAGTCCATCAAGTCTAGAATTTAA

AGAATTGATTACTATCGTGTCTCGATCTATCCGTCATTCACCTGAGTTTATCGCT

AAAAAACGCGGCATAGGGTCTGAGTATTTTTGCGCTTATTCCGATTGCAACTCAT

CCTTAAATTCTGAAGCTAACGCAGCTGCTAACGTAGCGCAAAAATTTCAAAAACA

GTTATTTTTTGAGTTATAA

SEQ
ATGAAGAGAATTCTGAACAGTCTGAAAGTTGCTGCCTTGAGACTTCTGTTTCGAG

ID
GCAAAGGTTCTGAATTAGTGAAGACAGTCAAATATCCATTGGTTTCCCCGGTTCA

NO:
AGGCGCGGTTGAAGAACTTGCTGAAGCAATTCGGCACGACAACCTGCACCTTTTT

37
GGGCAGAAGGAAATAGTGGATCTTATGGAGAAAGACGAAGGAACCCAGGTGTATT

CGGTTGTGGATTTTTGGTTGGATACCCTGCGTTTAGGGATGTTTTTCTCACCATC

AGCGAATGCGTTGAAAATCACGCTGGGAAAATTCAATTCTGATCAGGTTTCACCT

TTTCGTAAGGTTTTGGAGCAGTCACCTTTTTTTCTTGCGGGTCGCTTGAAGGTTG

AACCTGCGGAAAGGATACTTTCTGTTGAAATCAGAAAGATTGGTAAAAGAGAAAA

CAGAGTTGAGAACTATGCCGCCGATGTGGAGACATGCTTCATTGGTCAGCTTTCT

TCAGATGAGAAACAGAGTATCCAGAAGCTGGCAAATGATATCTGGGATAGCAAGG

ATCATGAGGAACAGAGAATGTTGAAGGCGGATTTTTTTGCTATACCTCTTATAAA

AGACCCCAAAGCTGTCACAGAAGAAGATCCTGAAAATGAAACGGCGGGAAAACAG

AAACCGCTTGAATTATGTGTTTGTCTTGTTCCTGAGTTGTATACCCGAGGTTTCG

GCTCCATTGCTGATTTTCTGGTTCAGCGACTTACCTTGCTGCGTGACAAAATGAG

TACCGACACGGCGGAAGATTGCCTCGAGTATGTTGGCATTGAGGAAGAAAAAGGC

AATGGAATGAATTCCTTGCTCGGCACTTTTTTGAAGAACCTGCAGGGTGATGGTT

TTGAACAGATTTTTCAGTTTATGCTTGGGTCTTATGTTGGCTGGCAGGGGAAGGA

AGATGTACTGCGCGAACGATTGGATTTGCTGGCCGAAAAAGTCAAAAGATTACCA

AAGCCAAAATTTGCCGGAGAATGGAGTGGTCATCGTATGTTTCTCCATGGTCAGC

TGAAAAGCTGGTCGTCGAATTTCTTCCGTCTTTTTAATGAGACGCGGGAACTTCT

GGAAAGTATCAAGAGTGATATTCAACATGCCACCATGCTCATTAGCTATGTGGAA

GAGAAAGGAGGCTATCATCCACAGCTGTTGAGTCAGTATCGGAAGTTAATGGAAC

AATTACCGGCGTTGCGGACTAAGGTTTTGGATCCTGAGATTGAGATGACGCATAT

GTCCGAGGCTGTTCGAAGTTACATTATGATACACAAGTCTGTAGCGGGATTTCTG

CCGGATTTACTCGAGTCTTTGGATCGAGATAAGGATAGGGAATTTTTGCTTTCCA

TCTTTCCTCGTATTCCAAAGATAGATAAGAAGACGAAAGAGATCGTTGCATGGGA

GCTACCGGGCGAGCCAGAGGAAGGCTATTTGTTCACAGCAAACAACCTTTTCCGG

AATTTTCTTGAGAATCCGAAACATGTGCCACGATTTATGGCAGAGAGGATTCCCG

AGGATTGGACGCGTTTGCGCTCGGCCCCTGTGTGGTTTGATGGGATGGTGAAGCA

ATGGCAGAAGGTGGTGAATCAGTTGGTTGAATCTCCAGGCGCCCTTTATCAGTTC

AATGAAAGTTTTTTGCGTCAAAGACTGCAAGCAATGCTTACGGTCTATAAGCGGG

ATCTCCAGACTGAGAAGTTTCTGAAGCTGCTGGCTGATGTCTGTCGTCCACTCGT

TGATTTTTTCGGACTTGGAGGAAATGATATTATCTTCAAGTCATGTCAGGATCCA

AGAAAGCAATGGCAGACTGTTATTCCACTCAGTGTCCCAGCGGATGTTTATACAG

CATGTGAAGGCTTGGCTATTCGTCTCCGCGAAACTCTTGGATTCGAATGGAAAAA

TCTGAAAGGACACGAGCGGGAAGATTTTTTACGGCTGCATCAGTTGCTGGGAAAT

CTGCTGTTCTGGATCAGGGATGCGAAACTTGTCGTGAAGCTGGAAGACTGGATGA

ACAATCCTTGTGTTCAGGAGTATGTGGAAGCACGAAAAGCCATTGATCTTCCCTT

GGAGATTTTCGGATTTGAGGTGCCGATTTTTCTCAATGGCTATCTCTTTTCGGAA

CTGCGCCAGCTGGAATTGTTGCTGAGGCGTAAGTCGGTGATGACGTCTTACAGCG

TCAAAACGACAGGCTCGCCAAATAGGCTCTTCCAGTTGGTTTACCTACCTCTAAA

CCCTTCAGATCCGGAAAAGAAAAATTCCAACAACTTTCAGGAGCGCCTCGATACA

CCTACCGGTTTGTCGCGTCGTTTTCTGGATCTTACGCTGGATGCATTTGCTGGCA

AACTCTTGACGGATCCGGTAACTCAGGAACTGAAGACGATGGCCGGTTTTTACGA

TCATCTCTTTGGCTTCAAGTTGCCGTGTAAACTGGCGGCGATGAGTAACCATCCA

GGATCCTCTTCCAAAATGGTGGTTCTGGCAAAACCAAAGAAGGGTGTTGCTAGTA

ACATCGGCTTTGAACCTATTCCCGATCCTGCTCATCCTGTGTTCCGGGTGAGAAG

TTCCTGGCCGGAGTTGAAGTACCTGGAGGGGTTGTTGTATCTTCCCGAAGATACA

CCACTGACCATTGAACTGGCGGAAACGTCGGTCAGTTGTCAGTCTGTGAGTTCAG

TCGCTTTCGATTTGAAGAATCTGACGACTATCTTGGGTCGTGTTGGTGAATTCAG

GGTGACGGCAGATCAACCTTTCAAGCTGACGCCCATTATTCCTGAGAAAGAGGAA

TCCTTCATCGGGAAGACCTACCTCGGTCTTGATGCTGGAGAGCGATCTGGCGTTG

GTTTCGCGATTGTGACGGTTGACGGCGATGGGTATGAGGTGCAGAGGTTGGGTGT

GCATGAAGATACTCAGCTTATGGCGCTTCAGCAAGTCGCCAGCAAGTCTCTTAAG

GAGCCGGTTTTCCAGCCACTCCGTAAGGGCACATTTCGTCAGCAGGAGCGCATTC

GCAAAAGCCTCCGCGGTTGCTACTGGAATTTCTATCATGCATTGATGATCAAGTA

CCGAGCTAAAGTTGTGCATGAGGAATCGGTGGGTTCATCCGGTCTGGTGGGGCAG

TGGCTGCGTGCATTTCAGAAGGATCTCAAAAAGGCTGATGTTCTGCCCAAGAAGG

GTGGAAAAAATGGTGTAGACAAAAAAAAGAGAGAAAGCAGCGCTCAGGATACCTT

ATGGGGAGGAGCTTTCTCGAAGAAGGAAGAGCAGCAGATAGCCTTTGAGGTTCAG

GCAGCTGGATCAAGCCAGTTTTGTCTGAAGTGTGGTTGGTGGTTTCAGTTGGGGA

TGCGGGAAGTAAATCGTGTGCAGGAGAGTGGCGTGGTGCTGGACTGGAACCGGTC

CATTGTAACCTTCCTCATCGAATCCTCAGGAGAAAAGGTATATGGTTTCAGTCCT

CAGCAACTGGAAAAAGGCTTTCGTCCTGACATCGAAACGTTCAAAAAAATGGTAA

GGGATTTTATGAGACCCCCCATGTTTGATCGCAAAGGTCGGCCGGCCGCGGCGTA

TGAAAGATTCGTACTGGGACGTCGTCACCGTCGTTATCGCTTTGATAAAGTTTTT

GAAGAGAGATTTGGTCGCAGTGCTCTTTTCATCTGCCCGCGGGTCGGGTGTGGGA

ATTTCGATCACTCCAGTGAGCAGTCAGCCGTTGTCCTTGCCCTTATTGGTTACAT

TGCTGATAAGGAAGGGATGAGTGGTAAGAAGCTTGTTTATGTGAGGCTGGCTGAA

CTTATGGCTGAGTGGAAGCTGAAGAAACTGGAGAGATCAAGGGTGGAAGAACAGA

GCTCGGCACAATAA

SEQ
ATGGCAGAAAGCAAGCAGATGCAATGCCGCAAGTGCGGCGCAAGCATGAAGTATG

ID
AAGTAATTGGATTGGGCAAGAAGTCATGCAGATATATGTGCCCAGATTGCGGCAA

NO:
TCACACCAGCGCGCGCAAGATTCAGAACAAGAAAAAGCGCGACAAAAAGTATGGA

38
TCCGCAAGCAAAGCGCAGAGCCAGAGGATAGCTGTGGCTGGCGCGCTTTATCCAG

ACAAAAAAGTGCAGACCATAAAGACCTACAAATACCCAGCGGATCTTAATGGCGA

AGTTCATGACAGCGGCGTCGCAGAGAAGATTGCGCAGGCGATTCAGGAAGATGAG

ATCGGCCTGCTTGGCCCGTCCAGCGAATACGCTTGCTGGATTGCTTCACAAAAAC

AGAGCGAGCCGTATTCAGTTGTAGATTTTTGGTTTGACGCGGTGTGCGCAGGCGG

AGTATTCGCGTATTCTGGCGCGCGCCTGCTTTCCACAGTCCTCCAGTTGAGTGGC

GAGGAAAGCGTTTTGCGCGCTGCTTTAGCATCTAGCCCGTTTGTAGATGACATTA

ATTTGGCGCAAGCGGAAAAGTTCCTAGCCGTTAGCCGGCGCACAGGCCAAGATAA

GCTAGGCAAGCGCATTGGAGAATGTTTTGCGGAAGGCCGGCTTGAAGCGCTTGGC

ATCAAAGATCGCATGCGCGAATTCGTGCAAGCGATTGATGTGGCCCAAACCGCGG

GCCAGCGGTTCGCGGCCAAGCTAAAGATATTCGGCATCAGTCAGATGCCTGAAGC

CAAGCAATGGAACAATGATTCCGGGCTCACTGTATGTATTTTGCCGGATTATTAT

GTCCCGGAAGAAAACCGCGCGGACCAGCTGGTTGTTTTGCTTCGGCGCTTACGCG

AGATCGCGTATTGCATGGGAATTGAGGATGAAGCAGGATTTGAGCATCTAGGCAT

TGACCCTGGTGCTCTTTCCAATTTTTCCAATGGCAATCCAAAGCGAGGATTTCTC

GGCCGCCTGCTCAATAATGACATTATAGCGCTGGCAAACAACATGTCAGCCATGA

CGCCGTATTGGGAAGGCAGAAAAGGCGAGTTGATTGAGCGCCTTGCATGGCTTAA

ACATCGCGCTGAAGGATTGTATTTGAAAGAGCCACATTTCGGCAACTCCTGGGCA

GACCACCGCAGCAGGATTTTCAGTCGCATTGCGGGCTGGCTTTCCGGATGCGCGG

GCAAGCTCAAGATTGCCAAGGATCAGATTTCAGGCGTGCGTACGGATTTGTTTCT

GCTCAAGCGCCTTCTGGATGCGGTACCGCAAAGCGCGCCGTCGCCGGACTTTATT

GCTTCCATCAGCGCGCTGGATCGGTTTTTGGAAGCGGCAGAAAGCAGCCAGGATC

CGGCAGAACAGGTACGCGCTTTGTACGCGTTTCATCTGAACGCGCCTGCGGTCCG

ATCCATCGCCAACAAGGCGGTACAGAGGTCTGATTCCCAGGAGTGGCTTATCAAG

GAACTGGATGCTGTAGATCACCTTGAATTCAACAAAGCATTTCCGTTTTTTTCGG

ATACAGGAAAGAAAAAGAAGAAAGGAGCGAATAGCAACGGAGCGCCTTCTGAAGA

AGAATACACGGAAACAGAATCCATTCAACAACCAGAAGATGCAGAGCAGGAAGTG

AATGGTCAAGAAGGAAATGGCGCTTCAAAGAACCAGAAAAAGTTTCAGCGCATTC

CTCGATTTTTCGGGGAAGGGTCAAGGAGTGAGTATCGAATTTTAACAGAAGCGCC

GCAATATTTTGACATGTTCTGCAATAATATGCGCGCGATCTTTATGCAGCTAGAG

AGTCAGCCGCGCAAGGCGCCTCGTGATTTCAAATGCTTTCTGCAGAATCGTTTGC

AGAAGCTTTACAAGCAAACCTTTCTCAATGCTCGCAGTAATAAATGCCGCGCGCT

TCTGGAATCCGTCCTTATTTCATGGGGAGAATTTTATACTTATGGCGCGAATGAA

AAGAAGTTTCGTCTGCGCCATGAAGCGAGCGAGCGCAGCTCGGATCCGGACTATG

TGGTTCAGCAGGCATTGGAAATCGCGCGCCGGCTTTTCTTGTTCGGATTTGAGTG

GCGCGATTGCTCTGCTGGAGAGCGCGTGGATTTGGTTGAAATCCACAAAAAAGCA

ATCTCATTTTTGCTTGCAATCACTCAGGCCGAGGTTTCAGTTGGTTCCTATAACT

GGCTTGGGAATAGCACCGTGAGCCGGTATCTTTCGGTTGCTGGCACAGACACATT

GTACGGCACTCAACTGGAGGAGTTTTTGAACGCCACAGTGCTTTCACAGATGCGT

GGGCTGGCGATTCGGCTTTCATCTCAGGAGTTAAAAGACGGATTTGATGTTCAGT

TGGAGAGTTCGTGCCAGGACAATCTCCAGCATCTGCTGGTGTATCGCGCTTCGCG

CGACTTGGCTGCGTGCAAACGCGCTACATGCCCGGCTGAATTGGATCCGAAAATT

CTTGTTCTGCCGGTTGGTGCGTTTATCGCGAGCGTAATGAAAATGATTGAGCGTG

GCGATGAACCATTAGCAGGCGCGTATTTGCGTCATCGGCCGCATTCATTCGGCTG

GCAGATACGGGTTCGTGGAGTGGCGGAAGTAGGCATGGATCAGGGCACAGCGCTA

GCATTCCAGAAGCCGACTGAATCAGAGCCGTTTAAAATAAAGCCGTTTTCCGCTC

AATACGGCCCAGTACTTTGGCTTAATTCTTCATCCTATAGCCAGAGCCAGTATCT

GGATGGATTTTTAAGCCAGCCAAAGAATTGGTCTATGCGGGTGCTACCTCAAGCC

GGATCAGTGCGCGTGGAACAGCGCGTTGCTCTGATATGGAATTTGCAGGCAGGCA

AGATGCGGCTGGAGCGCTCTGGAGCGCGCGCGTTTTTCATGCCAGTGCCATTCAG

CTTCAGGCCGTCTGGTTCAGGAGATGAAGCAGTATTGGCGCCGAATCGGTACTTG

GGACTTTTTCCGCATTCCGGAGGAATAGAATACGCGGTGGTGGATGTATTAGATT

CCGCGGGTTTCAAAATTCTTGAGCGCGGTACGATTGCGGTAAATGGCTTTTCCCA

GAAGCGCGGCGAACGCCAAGAGGAGGCACACAGAGAAAAACAGAGACGCGGAATT

TCTGATATAGGCCGCAAGAAGCCGGTGCAAGCTGAAGTTGACGCAGCCAATGAAT

TGCACCGCAAATACACCGATGTTGCCACTCGTTTAGGGTGCAGAATTGTGGTTCA

GTGGGCGCCCCAGCCAAAGCCGGGCACAGCGCCGACCGCGCAAACAGTATACGCG

CGCGCAGTGCGGACCGAAGCGCCGCGATCTGGAAATCAAGAGGATCATGCTCGTA

TGAAATCCTCTTGGGGATATACCTGGGGCACCTATTGGGAGAAGCGCAAACCAGA

GGATATTTTGGGCATCTCAACCCAAGTATACTGGACCGGCGGTATAGGCGAGTCA

TGTCCCGCAGTCGCGGTTGCGCTTTTGGGGCACATTAGGGCAACATCCACTCAAA

CTGAATGGGAAAAAGAGGAGGTTGTATTCGGTCGACTGAAGAAGTTCTTTCCAAG

CTAG

SEQ
ATGGAAAAGAGAATAAACAAGATACGAAAGAAACTATCGGCCGATAATGCCACAA

ID
AGCCTGTGAGCAGGAGCGGCCCCATGAAAACACTCCTTGTCCGGGTCATGACGGA

NO:
CGACTTGAAAAAAAGACTGGAGAAGCGTCGGAAAAAGCCGGAAGTTATGCCGCAG

39
GTTATTTCAAATAACGCAGCAAACAATCTTAGAATGCTCCTTGATGACTATACAA

AGATGAAGGAGGCGATACTACAAGTTTACTGGCAGGAATTTAAGGACGACCATGT

GGGCTTGATGTGCAAATTTGCCCAGCCTGCTTCCAAAAAAATTGACCAGAACAAA

CTAAAACCGGAAATGGATGAAAAAGGAAATCTAACAACTGCCGGTTTTGCATGTT

CTCAATGCGGTCAGCCGCTATTTGTTTATAAGCTTGAACAGGTGAGTGAAAAAGG

CAAGGCTTATACAAATTACTTCGGCCGGTGTAATGTGGCCGAGCATGAGAAATTG

ATTCTTCTTGCTCAATTAAAACCTGAAAAAGACAGTGACGAAGCAGTGACATACT

CCCTTGGCAAATTCGGCCAGAGGGCATTGGACTTTTATTCAATCCACGTAACAAA

AGAATCCACCCATCCAGTAAAGCCCCTGGCACAGATTGCGGGCAACCGCTATGCA

AGCGGACCTGTTGGCAAGGCCCTTTCCGATGCCTGTATGGGCACTATAGCCAGTT

TTCTTTCGAAATATCAAGACATCATCATAGAACATCAAAAGGTTGTGAAGGGTAA

TCAAAAGAGGTTAGAGAGTCTCAGGGAATTGGCAGGGAAAGAAAATCTTGAGTAC

CCATCGGTTACACTGCCGCCGCAGCCGCATACGAAAGAAGGGGTTGACGCTTATA

ACGAAGTTATTGCAAGGGTACGTATGTGGGTTAATCTTAATCTGTGGCAAAAGCT

GAAGCTCAGCCGTGATGACGCAAAACCGCTACTGCGGCTAAAAGGATTCCCATCT

TTCCCTGTTGTGGAGCGGCGTGAAAACGAAGTTGACTGGTGGAATACGATTAATG

AAGTAAAAAAACTGATTGACGCTAAACGAGATATGGGACGGGTATTCTGGAGCGG

CGTTACCGCAGAAAAGAGAAATACCATCCTTGAAGGATACAACTATCTGCCAAAT

GAGAATGACCATAAAAAGAGAGAGGGCAGTTTGGAAAACCCTAAGAAGCCTGCCA

AACGCCAGTTTGGAGACCTCTTGCTGTATCTTGAAAAGAAATATGCCGGAGACTG

GGGAAAGGTCTTCGATGAGGCATGGGAGAGGATAGATAAGAAAATAGCCGGACTC

ACAAGCCATATAGAGCGCGAAGAAGCAAGAAACGCGGAAGACGCTCAATCCAAAG

CCGTACTTACAGACTGGCTAAGGGCAAAGGCATCATTTGTTCTTGAAAGACTGAA

GGAAATGGATGAAAAGGAATTCTATGCGTGTGAAATCCAACTTCAAAAATGGTAT

GGCGATCTTCGAGGCAACCCGTTTGCCGTTGAAGCTGAGAATAGAGTTGTTGATA

TAAGCGGGTTTTCTATCGGAAGCGATGGCCATTCAATCCAATACAGAAATCTCCT

TGCCTGGAAATATCTGGAGAACGGCAAGCGTGAATTCTATCTGTTAATGAATTAT

GGCAAGAAAGGGCGCATCAGATTTACAGATGGAACAGATATTAAAAAGAGCGGCA

AATGGCAGGGACTATTATATGGCGGTGGCAAGGCAAAGGTTATTGATCTGACTTT

CGACCCCGATGATGAACAGTTGATAATCCTGCCGCTGGCCTTTGGCACAAGGCAA

GGCCGCGAGTTTATCTGGAACGATTTGCTGAGTCTTGAAACAGGCCTGATAAAGC

TCGCAAACGGAAGAGTTATCGAAAAAACAATCTATAACAAAAAAATAGGGCGGGA

TGAACCGGCTCTATTCGTTGCCTTAACATTTGAGCGCCGGGAAGTTGTTGATCCA

TCAAATATAAAGCCTGTAAACCTTATAGGCGTTGACCGCGGCGAAAACATCCCGG

CGGTTATTGCATTGACAGACCCTGAAGGTTGTCCTTTACCGGAATTCAAGGATTC

ATCAGGGGGCCCAACAGACATCCTGCGAATAGGAGAAGGATATAAGGAAAAGCAG

AGGGCTATTCAGGCAGCAAAGGAGGTAGAGCAAAGGCGGGCTGGCGGTTATTCAC

GGAAGTTTGCATCCAAGTCGAGGAACCTGGCGGACGACATGGTGAGAAATTCAGC

GCGAGACCTTTTTTACCATGCCGTTACCCACGATGCCGTCCTTGTCTTTGAAAAC

CTGAGCAGGGGTTTTGGAAGGCAGGGCAAAAGGACCTTCATGACGGAAAGACAAT

ATACAAAGATGGAAGACTGGCTGACAGCGAAGCTCGCATACGAAGGTCTTACGTC

AAAAACCTACCTTTCAAAGACGCTGGCGCAATATACGTCAAAAACATGCTCCAAC

TGCGGGTTTACTATAACGACTGCCGATTATGACGGGATGTTGGTAAGGCTTAAAA

AGACTTCTGATGGATGGGCAACTACCCTCAACAACAAAGAATTAAAAGCCGAAGG

CCAGATAACGTATTATAACCGGTATAAAAGGCAAACCGTGGAAAAAGAACTCTCC

GCAGAGCTTGACAGGCTTTCAGAAGAGTCGGGCAATAATGATATTTCTAAGTGGA

CCAAGGGTCGCCGGGACGAGGCATTATTTTTGTTAAAGAAAAGATTCAGCCATCG

GCCTGTTCAGGAACAGTTTGTTTGCCTCGATTGCGGCCATGAAGTCCACGCCGAT

GAACAGGCAGCCTTGAATATTGCAAGGTCATGGCTTTTTCTAAACTCAAATTCAA

CAGAATTCAAAAGTTATAAATCGGGTAAACAGCCCTTCGTTGGTGCTTGGCAGGC

CTTTTACAAAAGGAGGCTTAAAGAGGTATGGAAGCCCAACGCC

SEQ
ATGAAAAGGATAAATAAAATACGAAGGAGATTGGTAAAGGATAGCAACACGAAAA

ID
AAGCCGGCAAAACCGGCCCTATGAAAACCTTGCTCGTTCGGGTTATGACACCTGA

NO:
CCTGAGAGAAAGGTTAGAGAATCTTCGCAAAAAGCCGGAAAACATTCCTCAGCCC

40
ATTTCAAATACTTCACGTGCAAATTTAAATAAACTCCTCACTGACTATACGGAAA

TGAAGAAAGCAATCCTGCATGTTTATTGGGAAGAGTTCCAAAAAGACCCTGTCGG

ATTGATGAGCAGGGTTGCACAACCAGCGCCCAAGAATATTGATCAGAGAAAATTG

ATTCCGGTGAAGGACGGAAATGAGAGACTAACAAGTTCTGGATTTGCCTGTTCTC

AGTGCTGTCAACCCCTCTATGTTTATAAGCTTGAACAAGTGAATGACAAGGGTAA

GCCCCATACAAATTACTTTGGCCGTTGTAATGTCTCCGAGCATGAACGTTTGATA

TTGCTCTCGCCGCATAAACCGGAGGCAAATGACGAGCTAGTAACGTATTCGTTGG

GGAAGTTCGGTCAAAGGGCATTGGACTTTTATTCAATCCACGTAACAAGAGAATC

GAACCATCCTGTAAAGCCGCTAGAACAGATCGGTGGCAATAGCTGCGCAAGTGGT

CCCGTTGGTAAGGCTTTATCTGATGCCTGTATGGGAGCAGTAGCCAGTTTCCTTA

CAAAGTACCAGGACATCATCCTCGAACACCAAAAGGTTATAAAAAAAAACGAAAA

GAGATTGGCAAATCTAAAGGATATAGCAAGTGCAAACGGGCTTGCATTTCCTAAA

ATCACTCTTCCACCGCAACCGCATACAAAAGAAGGGATTGAAGCTTATAACAATG

TTGTTGCTCAGATAGTGATCTGGGTAAACCTGAATCTTTGGCAGAAACTCAAAAT

TGGCAGGGATGAGGCAAAGCCCTTACAGCGGCTTAAGGGTTTTCCGTCCTTCCCT

CTTGTTGAACGCCAGGCGAATGAGGTTGATTGGTGGGATATGGTCTGTAATGTCA

AAAAGTTGATTAACGAAAAGAAAGAGGACGGGAAGGTCTTCTGGCAAAATCTTGC

TGGATATAAAAGGCAGGAAGCCTTGCTTCCATATCTTTCGTCTGAAGAAGACCGT

AAAAAAGGAAAAAAGTTTGCGCGTTATCAGTTTGGTGACCTTTTGCTTCACCTTG

AAAAGAAACACGGTGAAGATTGGGGCAAAGTTTATGATGAGGCATGGGAAAGAAT

AGATAAAAAAGTTGAAGGTCTGAGTAAGCACATAAAGTTGGAGGAAGAAAGAAGG

TCTGAAGATGCTCAATCAAAGGCTGCCCTCACTGATTGGCTCAGGGCAAAGGCCT

CTTTTGTTATTGAAGGGCTCAAAGAAGCTGATAAGGATGAGTTTTGCAGGTGTGA

GTTAAAGCTTCAAAAGTGGTATGGAGATTTGAGAGGAAAACCATTTGCTATAGAA

GCAGAGAACAGCATTTTAGATATAAGCGGATTTTCTAAACAGTATAATTGTGCAT

TTATATGGCAGAAAGACGGCGTAAAGAAGTTAAATCTTTATTTAATAATAAATTA

CTTCAAAGGTGGTAAGCTACGCTTCAAAAAAATCAAGCCAGAAGCTTTTGAAGCA

AATAGGTTTTATACAGTAATTAATAAAAAAAGCGGTGAGATTGTGCCTATGGAGG

TCAACTTCAATTTTGATGACCCGAATTTGATAATTCTGCCTTTGGCCTTTGGAAA

AAGGCAGGGGAGGGAGTTTATCTGGAACGACCTATTGAGCCTTGAGACGGGTTCA

TTGAAACTCGCCAATGGCAGGGTTATTGAAAAAACGCTCTATAACAGAAGGACGA

GACAGGATGAACCAGCACTTTTTGTTGCCCTGACATTTGAAAGAAGAGAGGTGCT

TGACTCATCGAATATAAAACCGATGAATCTGATAGGAATAGACCGGGGAGAAAAT

ATCCCGGCAGTCATAGCATTAACAGACCCGGAAGGATGCCCCTTGTCAAGATTCA

AAGATTCATTGGGCAATCCAACGCATATTTTGCGAATAGGAGAAAGTTATAAGGA

AAAACAACGGACTATTCAGGCTGCTAAAGAAGTTGAACAAAGGCGGGCAGGCGGA

TATTCGAGAAAATATGCATCAAAGGCGAAGAATCTGGCGGACGATATGGTAAGAA

ATACAGCTCGTGACCTCTTATATTATGCTGTTACTCAAGATGCAATGCTCATTTT

TGAAAATCTTTCCCGCGGTTTTGGTAGACAAGGCAAGAGGACTTTTATGGCGGAA

AGGCAGTACACGAGGATGGAAGACTGGCTGACTGCAAAGCTTGCCTATGAAGGTC

TGCCATCAAAAACCTATCTTTCAAAGACTCTGGCACAGTATACCTCAAAGACATG

TTCTAATTGTGGTTTTACAATCACAAGTGCAGATTATGACAGGGTGCTCGAAAAG

CTCAAGAAGACGGCTACTGGATGGATGACTACAATCAATGGAAAAGAGTTAAAAG

TTGAAGGACAGATAACATACTATAACCGGTATAAAAGGCAGAATGTGGTAAAAGA

CCTCTCTGTAGAGCTGGATAGACTTTCGGAAGAGTCGGTAAATAATGATATTTCT

AGTTGGACAAAAGGCCGCAGTGGTGAAGCTTTATCTCTGCTAAAAAAGAGATTTA

GTCACAGGCCGGTGCAGGAAAAGTTTGTTTGCCTGAACTGTGGTTTTGAAACCCA

TGCAGACGAACAAGCAGCACTGAATATTGCAAGGTCGTGGCTCTTTCTCCGTTCT

CAAGAATATAAGAAGTATCAAACCAATAAAACGACCGGAAATACTGACAAAAGGG

CATTTGTTGAAACATGGCAATCCTTTTACAGAAAGAAGCTCAAAGAAGTATGGAA

ACCA

SEQ
ATGGGTAAAATGTATTACCTTGGTTTAGACATTGGCACGAATTCCGTGGGCTACG

ID
CGGTGACCGACCCCTCATACCACCTGCTGAAGTTTAAGGGGGAACCAATGTGGGG

NO:
TGCGCACGTATTTGCCGCCGGTAATCAGAGCGCGGAACGACGCTCGTTCCGCACA

41
TCGCGTCGTCGTTTGGACCGACGCCAACAGCGCGTTAAACTGGTACAGGAGATTT

TTGCCCCGGTGATTAGTCCGATCGACCCACGCTTCTTCATTCGTCTGCATGAATC

CGCCCTGTGGCGCGATGACGTCGCGGAGACGGATAAACATATCTTTTTCAATGAT

CCTACCTATACCGATAAGGAATATTATAGCGATTACCCGACTATCCATCACCTGA

TCGTTGATCTGATGGAAAGCTCTGAGAAACACGATCCGCGGCTGGTGTACCTTGC

AGTGGCGTGGTTAGTGGCACACCGTGGTCATTTTCTGAACGAGGTGGACAAGGAT

AATATTGGAGATGTGTTGTCGTTCGACGCATTTTATCCGGAGTTTCTCGCGTTCC

TGTCGGACAACGGTGTATCACCGTGGGTGTGCGAAAGCAAAGCGCTGCAGGCGAC

CTTGCTGAGCCGTAACTCAGTGAACGACAAATATAAAGCCCTTAAGTCTCTGATC

TTCGGATCCCAGAAACCTGAAGATAACTTCGATGCCAATATTTCGGAAGATGGAC

TCATTCAACTGCTGGCCGGCAAAAAGGTAAAAGTTAACAAACTGTTCCCTCAGGA

ATCGAACGATGCATCCTTCACATTGAATGATAAAGAAGACGCGATAGAAGAAATC

CTGGGTACGCTTACACCAGATGAATGTGAATGGATTGCGCATATACGCCGCCTTT

TTGACTGGGCTATCATGAAACATGCTCTGAAAGATGGCAGGACTATTAGCGAGTC

AAAAGTCAAACTGTATGAGCAGCACCATCACGATCTGACCCAACTTAAATACTTC

GTGAAAACCTACCTTGCAAAAGAATACGACGATATTTTCCGCAACGTGGATAGCG

AAACAACGAAAAACTATGTAGCGTATTCCTATCATGTGAAAGAGGTGAAAGGCAC

TCTGCCTAAAAATAAGGCAACGCAAGAAGAGTTTTGTAAGTATGTCCTGGGCAAG

GTTAAAAACATTGAATGCTCTGAAGCAGACAAGGTTGACTTTGATGAGATGATTC

AGCGTCTTACCGACAACTCTTTTATGCCTAAGCAGGTTTCGGGCGAAAACCGCGT

TATTCCTTATCAGTTATATTATTATGAACTGAAGACAATTCTGAATAAAGCAGCC

TCGTACCTGCCTTTCCTGACGCAGTGTGGAAAAGATGCAATTTCGAACCAGGACA

AACTACTGTCGATCATGACGTTCCGTATTCCTTACTTCGTCGGACCCTTGCGAAA

AGATAATTCGGAACATGCATGGCTCGAACGAAAGGCCGGTAAGATTTATCCGTGG

AACTTTAACGACAAAGTGGACTTGGATAAATCAGAAGAAGCGTTCATTCGCCGAA

TGACCAATACCTGTACCTATTATCCCGGCGAAGATGTTTTACCGTTGGATTCGCT

GATCTATGAGAAATTTATGATTTTAAATGAAATCAATAATATTCGTATTGACGGC

TACCCGATTAGTGTTGACGTTAAACAGCAGGTTTTTGGCTTGTTCGAAAAAAAAC

GACGCGTAACCGTGAAAGATATTCAGAACCTGCTGCTGTCTCTCGGAGCTCTGGA

CAAACACGGGAAGCTGACAGGCATCGATACCACTATCCACTCAAACTATAATACG

TATCACCATTTTAAATCTCTCATGGAACGCGGCGTCCTGACCCGGGATGACGTGG

AACGCATCGTTGAAAGGATGACCTACAGCGACGATACTAAGCGTGTGCGTCTGTG

GCTGAATAACAACTATGGTACTTTAACCGCCGACGATGTGAAACACATTTCGCGT

CTGCGCAAACACGATTTTGGCCGTTTATCCAAAATGTTCTTAACAGGTCTGAAGG

GTGTCCATAAGGAGACCGGTGAACGTGCCTCCATACTGGATTTCATGTGGAACAC

GAACGATAACCTGATGCAGCTCCTTTCCGAATGCTACACGTTCAGTGATGAAATC

ACAAAGCTGCAAGAGGCGTATTATGCAAAAGCCCAGTTGTCTTTAAACGATTTTT

TAGACTCGATGTACATCTCTAACGCGGTGAAACGTCCGATTTACAGAACTCTGGC

AGTGGTGAACGATATTCGAAAAGCATGTGGGACGGCCCCTAAACGCATTTTCATC

GAAATGGCTCGTGATGGTGAATCAAAAAAAAAGAGAAGTGTTACACGTCGCGAGC

AGATCAAAAACCTGTACCGCTCGATTCGTAAAGATTTCCAGCAGGAAGTTGATTT

TCTGGAAAAGATCCTGGAAAATAAATCTGATGGTCAACTTCAGTCAGATGCTTTG

TATCTTTACTTTGCACAATTAGGGCGCGATATGTACACGGGCGATCCAATAAAGC

TGGAGCACATCAAAGATCAGAGTTTCTATAACATAGACCATATTTACCCGCAGTC

TATGGTGAAAGACGATTCCCTAGATAACAAAGTGCTGGTGCAAAGCGAAATTAAC

GGCGAGAAAAGCTCGCGATACCCTTTGGACGCCGCGATCCGCAATAAAATGAAGC

CCCTTTGGGACGCTTACTATAATCATGGCCTGATCTCCTTAAAGAAATACCAGCG

TCTAACGCGCTCGACCCCGTTTACCGATGATGAAAAATGGGACTTTATTAATCGC

CAGTTAGTGGAAACCCGTCAATCTACCAAAGCGCTGGCCATTTTGTTGAAGCGTA

AGTTTCCAGACACCGAAATTGTGTATTCGAAGGCGGGGTTATCGTCCGACTTCAG

ACATGAATTCGGCCTTGTAAAAAGTCGCAATATTAATGATTTGCACCACGCTAAA

GACGCATTCTTGGCTATCGTTACCGGCAATGTGTACCATGAAAGATTCAATCGCA

GATGGTTTATGGTGAACCAGCCGTACTCAGTTAAAACTAAAACTCTTTTTACCCA

CAGCATAAAGAATGGCAACTTCGTTGCCTGGAACGGCGAAGAAGATCTCGGTCGT

ATTGTAAAAATGCTGAAGCAAAACAAAAATACCATTCACTTCACGCGCTTCTCCT

TCGATCGCAAAGAAGGATTATTTGATATCCAACCTCTGAAAGCCAGCACCGGCTT

AGTCCCACGAAAAGCCGGTCTGGATGTCGTTAAATACGGCGGATATGACAAATCT

ACCGCGGCCTATTACCTGCTGGTGAGGTTCACGCTCGAGGACAAGAAAACCCAGC

ACAAGCTGATGATGATTCCTGTAGAAGGCCTGTACAAGGCTCGCATTGATCATGA

CAAGGAATTTCTTACCGATTATGCGCAAACGACTATAAGCGAAATCCTACAGAAA

GATAAACAGAAAGTGATCAATATTATGTTTCCAATGGGTACGAGGCATATAAAAC

TCAATTCAATGATTAGTATCGATGGCTTCTATCTTAGTATCGGCGGAAAGTCCTC

TAAAGGTAAGTCAGTTCTATGTCACGCAATGGTTCCACTGATCGTCCCTCACAAA

ATCGAATGTTACATTAAAGCAATGGAAAGCTTCGCCCGGAAGTTTAAAGAAAACA

ACAAGCTGCGCATCGTAGAAAAATTCGATAAAATCACCGTTGAAGACAACCTGAA

TCTCTACGAGCTCTTTCTCCAAAAACTGCAGCATAATCCCTATAATAAGTTTTTT

TCGACACAGTTTGACGTACTGACGAACGGCCGTTCTACTTTCACAAAACTGTCGC

CGGAGGAACAGGTACAGACGCTCTTGAACATTTTAAGTATCTTTAAAACATGCCG

CAGTTCGGGTTGCGACCTGAAATCCATCAACGGCAGTGCCCAGGCAGCGCGCATC

ATGATTAGCGCTGACTTAACTGGACTGTCGAAAAAATATTCAGATATTAGGTTGG

TTGAACAGTCAGCTTCTGGTTTGTTCGTATCCAAAAGTCAGAACTTACTGGAGTA

TCTCTAA

SEQ
ATGTCATCGCTCACGAAATTCACTAACAAATACTCTAAACAGCTCACCATTAAGA

ID
ATGAACTCATCCCAGTTGGCAAAACACTGGAGAACATCAAAGAGAATGGTCTGAT

NO:
AGATGGCGACGAACAGCTGAATGAGAATTATCAGAAGGCGAAAATTATTGTGGAT

42
GATTTTCTGCGGGACTTCATTAATAAAGCACTGAATAATACGCAGATCGGGAACT

GGCGCGAACTGGCGGATGCCCTTAATAAAGAGGATGAAGATAACATCGAGAAATT

GCAGGATAAAATTCGGGGAATCATTGTATCCAAATTTGAAACGTTTGATCTGTTT

AGCAGCTATTCTATTAAGAAAGATGAAAAGATTATTGACGACGACAATGATGTTG

AAGAAGAGGAACTGGATCTGGGCAAGAAGACCAGCTCATTTAAATACATATTTAA

AAAAAACCTGTTTAAGTTAGTGTTGCCATCCTACCTGAAAACCACAAACCAGGAC

AAGCTGAAGATTATTAGCTCGTTTGATAATTTTTCAACGTACTTCCGCGGGTTCT

TTGAAAACCGGAAAAACATTTTTACCAAGAAACCGATCTCCACAAGTATTGCGTA

TCGCATTGTTCATGATAACTTCCCGAAATTCCTTGATAACATTCGTTGTTTTAAT

GTGTGGCAGACGGAATGCCCGCAACTAATCGTGAAAGCAGATAACTATCTGAAAA

GCAAAAATGTTATAGCGAAAGATAAAAGTTTGGCAAACTATTTTACCGTGGGCGC

GTATGACTATTTCCTGTCTCAGAATGGTATAGATTTTTACAACAATATTATAGGT

GGACTGCCAGCGTTCGCCGGCCATGAGAAAATCCAAGGTCTCAATGAATTCATCA

ATCAAGAGTGCCAAAAAGACAGCGAGCTGAAAAGTAAGCTGAAAAACCGTCACGC

GTTCAAAATGGCGGTACTGTTCAAACAGATACTCAGCGATCGTGAAAAAAGTTTT

GTAATTGATGAGTTCGAGTCGGATGCTCAAGTTATTGACGCCGTTAAAAACTTTT

ACGCCGAACAGTGCAAAGATAACAATGTTATTTTTAACTTATTAAATCTTATCAA

GAATATCGCTTTCTTAAGTGATGACGAACTGGACGGCATATTCATTGAAGGGAAA

TACCTGTCGAGCGTTAGTCAAAAACTCTATAGCGATTGGTCAAAATTACGTAACG

ACATTGAGGATTCGGCTAACTCTAAACAAGGCAATAAAGAGCTGGCCAAGAAGAT

CAAAACCAACAAAGGGGATGTAGAAAAAGCGATCTCGAAATATGAGTTCTCGCTG

TCGGAACTGAACTCGATTGTACATGATAACACCAAGTTTTCTGACCTCCTTAGTT

GTACACTGCATAAGGTGGCTTCTGAGAAACTGGTGAAGGTCAATGAAGGCGACTG

GCCGAAACATCTCAAGAATAATGAAGAGAAACAAAAAATCAAAGAGCCGCTTGAT

GCTCTGCTGGAGATCTATAATACACTTCTGATTTTTAACTGCAAAAGCTTCAATA

AAAACGGCAACTTCTATGTCGACTATGATCGTTGCATCAATGAACTGAGTTCGGT

CGTGTATCTGTATAATAAAACACGTAACTATTGCACTAAAAAACCCTATAACACG

GACAAGTTCAAACTCAATTTTAACAGTCCGCAGCTCGGTGAAGGCTTTTCCAAGT

CGAAAGAAAATGACTGTCTGACTCTTTTGTTTAAAAAAGACGACAACTATTATGT

AGGCATTATCCGCAAAGGTGCAAAAATCAATTTTGATGATACACAAGCAATCGCC

GATAACACCGACAATTGCATCTTTAAAATGAATTATTTCCTACTTAAAGACGCAA

AAAAATTTATCCCGAAATGTAGCATTCAGCTGAAAGAAGTCAAGGCCCATTTTAA

GAAATCTGAAGATGATTACATTTTGTCTGATAAAGAGAAATTTGCTAGCCCGCTG

GTCATTAAAAAGAGCACATTTTTGCTGGCAACTGCACATGTGAAAGGGAAAAAAG

GCAATATCAAGAAATTTCAGAAAGAATATTCGAAAGAAAACCCCACTGAGTATCG

CAATTCTTTAAACGAATGGATTGCTTTTTGTAAAGAGTTCTTAAAAACTTATAAA

GCGGCTACCATTTTTGATATAACCACATTGAAAAAGGCAGAGGAATATGCTGATA

TTGTAGAATTCTACAAGGATGTCGATAATCTGTGCTACAAACTGGAGTTCTGCCC

GATTAAAACCTCGTTTATAGAAAACCTGATAGATAACGGCGACCTGTATCTGTTT

CGCATCAATAACAAAGACTTCAGCAGTAAATCGACCGGCACCAAGAACCTTCATA

CGTTATATTTACAAGCTATATTCGATGAACGTAATCTGAACAATCCGACAATTAT

GCTGAATGGGGGAGCAGAACTGTTCTATCGTAAAGAAAGTATTGAGCAGAAAAAC

CGTATCACACACAAAGCCGGTTCAATTCTCGTGAATAAGGTGTGTAAAGACGGTA

CAAGCCTGGATGATAAGATACGTAATGAAATTTATCAATATGAGAATAAATTTAT

TGATACCCTGTCTGATGAAGCTAAAAAGGTGTTACCGAATGTCATTAAAAAGGAA

GCTACCCATGACATTACAAAAGATAAACGTTTCACTAGTGACAAATTCTTCTTTC

ACTGCCCCCTGACAATTAATTATAAGGAAGGCGATACCAAGCAGTTCAATAACGA

AGTGCTGAGTTTTCTGCGTGGAAATCCTGACATCAACATTATCGGCATTGACCGC

GGAGAGCGTAATTTAATCTATGTAACGGTTATAAACCAGAAAGGCGAGATTCTGG

ATTCGGTTTCATTCAATACCGTGACCAACAAGAGTTCAAAAATCGAGCAGACAGT

CGATTATGAAGAGAAATTGGCAGTCCGCGAGAAAGAGAGGATTGAAGCAAAACGT

TCCTGGGACTCTATCTCAAAAATTGCGACACTAAAGGAAGGTTATCTGAGCGCAA

TAGTTCACGAGATCTGTCTGTTAATGATTAAACACAACGCGATCGTTGTCTTAGA

GAATCTTAATGCAGGCTTTAAGCGTATTCGTGGCGGTTTATCAGAAAAAAGTGTT

TATCAAAAATTCGAAAAAATGTTGATTAACAAACTGAACTATTTTGTCAGCAAGA

AGGAATCCGACTGGAATAAACCGTCTGGTCTGCTGAATGGACTGCAGCTTTCGGA

TCAGTTTGAAAGCTTCGAAAAACTGGGTATTCAGTCTGGTTTTATTTTTTACGTG

CCGGCTGCATATACCTCAAAGATTGATCCGACCACGGGCTTCGCCAATGTTCTGA

ATCTGTCGAAGGTACGCAATGTTGATGCGATCAAAAGCTTTTTTTCTAACTTCAA

CGAAATTAGTTATAGCAAGAAAGAAGCCCTTTTCAAATTCTCATTCGATCTGGAT

TCACTGAGTAAGAAAGGCTTTAGTAGCTTTGTGAAATTTAGTAAGAGTAAATGGA

ACGTCTACACCTTTGGAGAACGTATCATAAAGCCAAAGAATAAGCAAGGTTATCG

GGAGGACAAAAGAATCAACTTGACCTTCGAGATGAAGAAGTTACTTAACGAGTAT

AAGGTTTCTTTTGATCTTGAAAATAACTTGATTCCGAATCTCACGAGTGCCAACC

TGAAGGATACTTTTTGGAAAGAGCTATTCTTTATCTTCAAGACTACGCTGCAGCT

CCGTAACAGCGTTACTAACGGTAAAGAAGATGTGCTCATCTCTCCGGTCAAAAAT

GCGAAGGGTGAATTCTTCGTTTCGGGAACGCATAACAAGACTCTTCCGCAAGATT

GCGATGCGAACGGTGCATACCATATTGCGTTGAAAGGTCTGATGATACTCGAACG

TAACAACCTTGTACGTGAGGAGAAAGATACGAAAAAGATTATGGCGATTTCAAAC

GTGGATTGGTTCGAGTACGTGCAGAAACGTAGAGGCGTTCTGTAA

SEQ
ATGAACAACTACGACGAATTCACCAAACTGTACCCGATCCAGAAAACCATCCGTT

ID
TCGAACTGAAACCGCAGGGTCGTACCATGGAACACCTGGAAACCTTCAACTTCTT

NO:
CGAAGAAGACCGTGACCGTGCGGAAAAATACAAAATCCTGAAAGAAGCGATCGAC

43
GAATACCACAAAAAATTCATCGACGAACACCTGACCAACATGTCTCTGGACTGGA

ACTCTCTGAAACAGATCTCTGAAAAATACTACAAATCTCGTGAAGAAAAAGACAA

AAAAGTTTTCCTGTCTGAACAGAAACGTATGCGTCAGGAAATCGTTTCTGAATTC

AAAAAAGACGACCGTTTCAAAGACCTGTTCTCTAAAAAACTGTTCTCTGAACTGC

TGAAAGAAGAAATCTACAAAAAAGGTAACCACCAGGAAATCGACGCGCTGAAATC

TTTCGACAAATTCTCTGGTTACTTCATCGGTCTGCACGAAAACCGTAAAAACATG

TACTCTGACGGTGACGAAATCACCGCGATCTCTAACCGTATCGTTAACGAAAACT

TCCCGAAATTCCTGGACAACCTGCAGAAATACCAGGAAGCGCGTAAAAAATACCC

GGAATGGATCATCAAAGCGGAATCTGCGCTGGTTGCGCACAACATCAAAATGGAC

GAAGTTTTCTCTCTGGAATACTTCAACAAAGTTCTGAACCAGGAAGGTATCCAGC

GTTACAACCTGGCGCTGGGTGGTTACGTTACCAAATCTGGTGAAAAAATGATGGG

TCTGAACGACGCGCTGAACCTGGCGCACCAGTCTGAAAAATCTTCTAAAGGTCGT

ATCCACATGACCCCGCTGTTCAAACAGATCCTGTCTGAAAAAGAATCTTTCTCTT

ACATCCCGGACGTTTTCACCGAAGACTCTCAGCTGCTGCCGTCTATCGGTGGTTT

CTTCGCGCAGATCGAAAACGACAAAGACGGTAACATCTTCGACCGTGCGCTGGAA

CTGATCTCTTCTTACGCGGAATACGACACCGAACGTATCTACATCCGTCAGGCGG

ACATCAACCGTGTTTCTAACGTTATCTTCGGTGAATGGGGTACCCTGGGTGGTCT

GATGCGTGAATACAAAGCGGACTCTATCAACGACATCAACCTGGAACGTACCTGC

AAAAAAGTTGACAAATGGCTGGACTCTAAAGAATTCGCGCTGTCTGACGTTCTGG

AAGCGATCAAACGTACCGGTAACAACGACGCGTTCAACGAATACATCTCTAAAAT

GCGTACCGCGCGTGAAAAAATCGACGCGGCGCGTAAAGAAATGAAATTCATCTCT

GAAAAAATCTCTGGTGACGAAGAATCTATCCACATCATCAAAACCCTGCTGGACT

CTGTTCAGCAGTTCCTGCACTTCTTCAACCTGTTCAAAGCGCGTCAGGACATCCC

GCTGGACGGTGCGTTCTACGCGGAATTCGACGAAGTTCACTCTAAACTGTTCGCG

ATCGTTCCGCTGTACAACAAAGTTCGTAACTACCTGACCAAAAACAACCTGAACA

CCAAAAAAATCAAACTGAACTTCAAAAACCCGACCCTGGCGAACGGTTGGGACCA

GAACAAAGTTTACGACTACGCGTCTCTGATCTTCCTGCGTGACGGTAACTACTAC

CTGGGTATCATCAACCCGAAACGTAAAAAAAACATCAAATTCGAACAGGGTTCTG

GTAACGGTCCGTTCTACCGTAAAATGGTTTACAAACAGATCCCGGGTCCGAACAA

AAACCTGCCGCGTGTTTTCCTGACCTCTACCAAAGGTAAAAAAGAATACAAACCG

TCTAAAGAAATCATCGAAGGTTACGAAGCGGACAAACACATCCGTGGTGACAAAT

TCGACCTGGACTTCTGCCACAAACTGATCGACTTCTTCAAAGAATCTATCGAAAA

ACACAAAGACTGGTCTAAATTCAACTTCTACTTCTCTCCGACCGAATCTTACGGT

GACATCTCTGAATTCTACCTGGACGTTGAAAAACAGGGTTACCGTATGCACTTCG

AAAACATCTCTGCGGAAACCATCGACGAATACGTTGAAAAAGGTGACCTGTTCCT

GTTCCAGATCTACAACAAAGACTTCGTTAAAGCGGCGACCGGTAAAAAAGACATG

CACACCATCTACTGGAACGCGGCGTTCTCTCCGGAAAACCTGCAGGACGTTGTTG

TTAAACTGAACGGTGAAGCGGAACTGTTCTACCGTGACAAATCTGACATCAAAGA

AATCGTTCACCGTGAAGGTGAAATCCTGGTTAACCGTACCTACAACGGTCGTACC

CCGGTTCCGGACAAAATCCACAAAAAACTGACCGACTACCACAACGGTCGTACCA

AAGACCTGGGTGAAGCGAAAGAATACCTGGACAAAGTTCGTTACTTCAAAGCGCA

CTACGACATCACCAAAGACCGTCGTTACCTGAACGACAAAATCTACTTCCACGTT

CCGCTGACCCTGAACTTCAAAGCGAACGGTAAAAAAAACCTGAACAAAATGGTTA

TCGAAAAATTCCTGTCTGACGAAAAAGCGCACATCATCGGTATCGACCGTGGTGA

ACGTAACCTGCTGTACTACTCTATCATCGACCGTTCTGGTAAAATCATCGACCAG

CAGTCTCTGAACGTTATCGACGGTTTCGACTACCGTGAAAAACTGAACCAGCGTG

AAATCGAAATGAAAGACGCGCGTCAGTCTTGGAACGCGATCGGTAAAATCAAAGA

CCTGAAAGAAGGTTACCTGTCTAAAGCGGTTCACGAAATCACCAAAATGGCGATC

CAGTACAACGCGATCGTTGTTATGGAAGAACTGAACTACGGTTTCAAACGTGGTC

GTTTCAAAGTTGAAAAACAGATCTACCAGAAATTCGAAAACATGCTGATCGACAA

AATGAACTACCTGGTTTTCAAAGACGCGCCGGACGAATCTCCGGGTGGTGTTCTG

AACGCGTACCAGCTGACCAACCCGCTGGAATCTTTCGCGAAACTGGGTAAACAGA

CCGGTATCCTGTTCTACGTTCCGGCGGCGTACACCTCTAAAATCGACCCGACCAC

CGGTTTCGTTAACCTGTTCAACACCTCTTCTAAAACCAACGCGCAGGAACGTAAA

GAATTCCTGCAGAAATTCGAATCTATCTCTTACTCTGCGAAAGACGGTGGTATCT

TCGCGTTCGCGTTCGACTACCGTAAATTCGGTACCTCTAAAACCGACCACAAAAA

CGTTTGGACCGCGTACACCAACGGTGAACGTATGCGTTACATCAAAGAAAAAAAA

CGTAACGAACTGTTCGACCCGTCTAAAGAAATCAAAGAAGCGCTGACCTCTTCTG

GTATCAAATACGACGGTGGTCAGAACATCCTGCCGGACATCCTGCGTTCTAACAA

CAACGGTCTGATCTACACCATGTACTCTTCTTTCATCGCGGCGATCCAGATGCGT

GTTTACGACGGTAAAGAAGACTACATCATCTCTCCGATCAAAAACTCTAAAGGTG

AATTCTTCCGTACCGACCCGAAACGTCGTGAACTGCCGATCGACGCGGACGCGAA

CGGTGCGTACAACATCGCGCTGCGTGGTGAACTGACCATGCGTGCGATCGCGGAA

AAATTCGACCCGGACTCTGAAAAAATGGCGAAACTGGAACTGAAACACAAAGACT

GGTTCGAATTCATGCAGACCCGTGGTGACTAA

SEQ
ATGACTAAAACATTTGATTCAGAGTTTTTTAATTTGTACTCGCTGCAAAAAACGG

ID
TACGCTTTGAGTTAAAACCCGTGGGAGAAACCGCGTCATTTGTGGAAGACTTTAA

NO:
AAACGAGGGCTTGAAACGTGTTGTGAGCGAAGATGAAAGGCGAGCCGTCGATTAC

44
CAGAAAGTTAAGGAAATAATTGACGATTACCATCGGGATTTCATTGAAGAAAGTT

TAAATTATTTTCCGGAACAGGTGAGTAAAGATGCTCTTGAGCAGGCGTTTCATCT

TTATCAGAAACTGAAGGCAGCAAAAGTTGAGGAAAGGGAAAAAGCGCTGAAAGAA

TGGGAAGCGCTGCAGAAAAAGCTACGTGAAAAAGTGGTGAAATGCTTCTCGGACT

CGAATAAAGCCCGCTTCTCAAGGATTGATAAAAAGGAACTGATTAAGGAAGACCT

GATAAATTGGTTGGTCGCCCAGAATCGCGAGGATGATATCCCTACGGTCGAAACG

TTTAACAACTTCACCACATATTTTACCGGCTTCCATGAGAATCGTAAAAATATTT

ACTCCAAAGATGATCACGCCACCGCTATTAGCTTTCGCCTTATTCATGAAAATCT

TCCAAAGTTTTTTGACAACGTGATTAGCTTCAATAAGTTGAAAGAGGGTTTCCCT

GAATTAAAATTTGATAAAGTGAAAGAGGATTTAGAAGTAGATTATGATCTGAAGC

ATGCGTTTGAAATAGAATATTTCGTTAACTTCGTGACCCAAGCGGGCATAGATCA

GTATAATTATCTGTTAGGAGGGAAAACCCTGGAGGACGGGACGAAAAAACAAGGG

ATGAATGAGCAAATTAATCTGTTCAAACAACAGCAAACGCGAGATAAAGCGCGTC

AGATTCCCAAACTGATCCCCCTGTTCAAACAGATTCTTAGCGAAAGGACTGAAAG

CCAGTCCTTTATTCCTAAACAATTTGAAAGTGATCAGGAGTTGTTCGATTCACTG

CAGAAGTTACATAATAACTGCCAGGATAAATTCACCGTGCTGCAACAAGCCATTC

TCGGTCTGGCAGAGGCGGATCTTAAGAAGGTCTTCATCAAAACCTCTGATTTAAA

TGCCTTATCTAACACCATTTTCGGGAATTACAGCGTCTTTTCCGATGCACTGAAC

CTGTATAAAGAAAGCCTGAAAACGAAAAAAGCGCAGGAGGCTTTTGAGAAACTAC

CGGCCCATTCTATTCACGACCTCATTCAATACTTGGAACAGTTCAATTCCAGCCT

GGACGCGGAAAAACAACAGAGCACCGACACCGTCCTGAACTACTTCATCAAGACC

GATGAATTATATTCTCGCTTCATTAAATCCACTAGCGAGGCTTTCACTCAGGTGC

AGCCTTTGTTCGAACTGGAAGCCCTGTCATCTAAGCGCCGCCCACCGGAATCGGA

AGATGAAGGGGCAAAAGGGCAGGAAGGCTTCGAGCAGATCAAGCGTATTAAAGCT

TACCTGGATACGCTTATGGAAGCGGTACACTTTGCAAAGCCGTTGTATCTTGTTA

AGGGTCGTAAAATGATCGAAGGGCTCGATAAAGACCAGTCCTTTTATGAAGCGTT

TGAAATGGCGTACCAAGAACTTGAATCGTTAATCATTCCTATCTATAACAAAGCG

CGGAGCTATCTGTCGCGGAAACCTTTCAAGGCCGATAAATTCAAGATTAATTTTG

ACAACAACACGCTACTGAGCGGATGGGATGCGAACAAGGAAACTGCTAACGCGTC

CATTCTGTTTAAGAAAGACGGGTTATATTACCTTGGAATTATGCCGAAAGGTAAG

ACCTTTCTCTTTGACTACTTTGTATCGAGCGAGGATTCAGAGAAACTGAAACAGC

GTCGCCAGAAGACCGCCGAAGAAGCTCTGGCGCAGGATGGTGAAAGTTACTTCGA

AAAAATTCGTTATAAACTGTTACCAGGGGCTTCAAAGATGTTACCGAAAGTCTTT

TTTAGCAACAAAAATATTGGCTTTTACAACCCGTCGGATGACATTTTACGCATTC

GCAACACAGCCTCTCACACCAAAAACGGGACCCCTCAGAAAGGCCACTCAAAAGT

TGAGTTTAACCTGAATGATTGTCATAAGATGATTGATTTCTTCAAATCATCAATT

CAGAAACACCCGGAATGGGGGTCTTTTGGCTTTACGTTTTCTGATACCAGTGATT

TTGAAGACATGAGTGCCTTCTACCGGGAAGTAGAAAACCAGGGTTACGTAATTAG

CTTTGACAAAATCAAAGAGACCTATATACAGAGCCAGGTGGAACAGGGTAATCTC

TACTTATTCCAGATTTATAACAAGGATTTCTCGCCCTACAGCAAAGGCAAACCAA

ACCTGCATACTCTGTACTGGAAAGCCCTGTTTGAAGAAGCGAACCTGAATAACGT

AGTGGCGAAGTTGAACGGTGAAGCGGAAATCTTCTTCCGTCGTCACTCCATTAAG

GCCTCTGATAAAGTTGTCCATCCGGCAAATCAGGCCATTGATAATAAGAATCCAC

ACACGGAAAAAACGCAGTCAACCTTTGAATATGACCTCGTTAAAGACAAACGCTA

CACGCAAGATAAGTTCTTTTTCCACGTCCCAATCAGCCTCAACTTTAAAGCACAA

GGGGTTTCAAAGTTTAATGATAAAGTCAATGGGTTCCTCAAGGGCAACCCGGATG

TCAACATTATAGGTATAGACAGGGGCGAACGCCATCTGCTTTACTTTACCGTAGT

GAATCAGAAAGGTGAAATACTGGTTCAGGAATCATTAAATACCTTGATGTCGGAC

AAAGGGCACGTTAATGATTACCAGCAGAAACTGGATAAAAAAGAACAGGAACGTG

ATGCTGCGCGTAAATCGTGGACCACGGTTGAGAACATTAAAGAGCTGAAAGAGGG

GTATCTAAGCCATGTGGTACACAAACTGGCGCACCTCATCATTAAATATAACGCA

ATAGTCTGCCTAGAAGACTTGAATTTTGGCTTTAAACGCGGCCGCTTCAAAGTGG

AAAAACAAGTTTATCAAAAATTTGAAAAGGCGCTTATAGATAAACTGAATTATCT

GGTTTTTAAAGAAAAGGAACTTGGTGAGGTAGGGCACTACTTGACAGCTTATCAA

CTGACGGCCCCGTTCGAATCATTCAAAAAACTGGGCAAACAGTCTGGCATTCTGT

TTTACGTGCCGGCAGATTATACTTCAAAAATCGATCCAACAACTGGCTTTGTGAA

CTTCCTGGACCTGAGATATCAGTCTGTAGAAAAAGCTAAACAACTTCTTAGCGAT

TTTAATGCCATTCGTTTTAACAGCGTTCAGAATTACTTTGAATTCGAAATTGACT

ATAAAAAACTTACTCCGAAACGTAAAGTCGGAACCCAAAGTAAATGGGTAATTTG

TACGTATGGCGATGTCAGGTATCAGAACCGTCGGAATCAAAAAGGTCATTGGGAG

ACCGAAGAAGTGAACGTGACCGAAAAGCTGAAGGCTCTGTTCGCCAGCGATTCAA

AAACTACAACTGTGATCGATTACGCAAATGATGATAACCTGATAGATGTGATTTT

AGAGCAGGATAAAGCCAGCTTTTTTAAAGAACTGTTGTGGCTCCTGAAACTTACG

ATGACCTTACGACATTCCAAGATCAAATCGGAAGATGATTTTATTCTGTCACCGG

TCAAGAATGAGCAGGGTGAATTCTATGATAGTAGGAAAGCCGGCGAAGTGTGGCC

GAAAGACGCCGACGCCAATGGCGCCTATCATATCGCGCTCAAAGGGCTTTGGAAT

TTGCAGCAGATTAACCAGTGGGAAAAAGGTAAAACCCTGAATCTGGCTATCAAAA

ACCAGGATTGGTTTAGCTTTATCCAAGAGAAACCGTATCAGGAATGA

SEQ
ATGCATACAGGCGGTCTTCTTAGTATGGACGCGAAAGAGTTCACAGGTCAGTATC

ID
CGTTGTCGAAAACATTACGATTCGAACTTCGGCCCATCGGCCGCACGTGGGATAA

NO:
CCTGGAGGCCTCAGGCTACTTAGCGGAAGACCGCCATCGTGCCGAATGTTATCCT

45
CGTGCGAAAGAGTTATTGGATGACAACCATCGTGCCTTCCTGAATCGTGTGTTGC

CACAAATCGATATGGATTGGCACCCGATTGCGGAGGCCTTTTGTAAGGTACATAA

AAACCCTGGTAATAAAGAACTTGCCCAGGATTACAACCTTCAGTTGTCAAAGCGC

CGTAAGGAGATCAGCGCATATCTTCAGGATGCAGATGGCTATAAAGGCCTGTTCG

CGAAGCCCGCCTTAGACGAAGCTATGAAAATTGCGAAAGAAAACGGGAACGAAAG

TGATATTGAGGTTCTCGAAGCGTTTAACGGTTTTAGCGTATACTTCACCGGTTAT

CATGAGTCACGCGAGAACATTTATAGCGATGAGGATATGGTGAGCGTAGCCTACC

GAATTACTGAGGATAATTTCCCGCGCTTTGTCTCAAACGCTTTGATCTTTGATAA

ATTAAACGAAAGCCATCCGGATATTATCTCTGAAGTATCGGGCAATCTTGGAGTT

GATGACATTGGTAAGTACTTTGACGTGTCGAACTATAACAATTTTCTTTCCCAGG

CCGGTATAGATGACTACAATCACATTATTGGCGGCCATACAACCGAAGACGGACT

GATACAAGCGTTTAATGTCGTATTGAACTTACGTCACCAAAAAGACCCTGGCTTT

GAAAAAATTCAGTTCAAACAGCTCTACAAACAAATCCTGAGCGTGCGTACCAGCA

AAAGCTACATCCCGAAACAGTTTGACAACTCTAAGGAGATGGTTGACTGCATTTG

CGATTATGTCAGCAAAATAGAGAAATCCGAAACAGTAGAACGGGCCCTGAAACTA

GTCCGTAATATCAGTTCTTTCGACTTGCGCGGGATCTTTGTCAATAAAAAGAACT

TGCGCATACTGAGCAACAAACTGATAGGAGATTGGGACGCGATCGAAACCGCATT

GATGCATAGTTCTTCATCAGAAAACGATAAGAAAAGCGTATATGATAGCGCGGAG

GCTTTTACGTTGGATGACATCTTTTCAAGCGTGAAAAAATTTTCTGATGCCTCTG

CCGAAGATATTGGCAACAGGGCGGAAGACATCTGTAGAGTGATAAGTGAGACGGC

CCCTTTTATCAACGATCTGCGAGCGGTGGACCTGGATAGCCTGAACGACGATGGT

TATGAAGCGGCCGTCTCAAAAATTCGGGAGTCGCTGGAGCCTTATATGGATCTTT

TCCATGAACTGGAAATTTTCTCGGTTGGCGATGAGTTCCCAAAATGCGCAGCATT

TTACAGCGAACTGGAGGAAGTCAGCGAACAGCTGATCGAAATTATTCCGTTATTC

AACAAGGCGCGTTCGTTCTGCACCCGGAAACGCTATAGCACCGATAAGATTAAAG

TGAACTTAAAATTCCCGACCTTGGCGGACGGGTGGGACCTGAACAAAGAGAGAGA

CAACAAAGCCGCGATTCTGCGGAAAGACGGTAAGTATTATCTGGCAATTCTGGAT

ATGAAGAAAGATCTGTCAAGCATTAGGACCAGCGACGAAGATGAATCCAGCTTCG

AAAAGATGGAGTATAAACTGTTACCGAGTCCAGTAAAAATGCTGCCAAAGATATT

CGTAAAATCGAAAGCCGCTAAGGAAAAATATGGCCTGACAGATCGTATGCTTGAA

TGCTACGATAAAGGTATGCATAAGTCGGGTAGTGCGTTTGATCTTGGCTTTTGCC

ATGAACTCATTGATTATTACAAGCGTTGTATCGCGGAGTACCCAGGCTGGGATGT

GTTCGATTTCAAGTTTCGCGAAACTTCCGATTATGGGTCCATGAAAGAGTTCAAT

GAAGATGTGGCCGGAGCCGGTTACTATATGAGTCTGAGAAAAATTCCGTGCAGCG

AAGTGTACCGTCTGTTAGACGAGAAATCGATTTATCTATTTCAAATTTATAACAA

AGATTACTCTGAAAATGCACATGGTAATAAGAACATGCATACCATGTACTGGGAG

GGTCTCTTTTCCCCGCAAAACCTGGAGTCGCCCGTTTTCAAGTTGTCGGGTGGGG

CAGAACTTTTCTTTCGAAAATCCTCAATCCCTAACGATGCCAAAACAGTACACCC

GAAAGGCTCAGTGCTGGTTCCACGTAATGATGTTAACGGTCGGCGTATTCCAGAT

TCAATCTACCGCGAACTGACACGCTATTTTAACCGTGGCGATTGCCGAATCAGTG

ACGAAGCCAAAAGTTATCTTGACAAGGTTAAGACTAAAAAAGCGGACCATGACAT

TGTGAAAGATCGCCGCTTTACCGTGGATAAAATGATGTTCCACGTCCCGATTGCG

ATGAACTTTAAGGCGATCAGTAAACCGAACTTAAACAAAAAAGTCATTGATGGCA

TCATTGATGATCAGGATCTGAAAATCATTGGTATTGATCGTGGCGAGCGGAACTT

AATTTACGTCACGATGGTTGACAGAAAAGGGAATATCTTATATCAGGATTCTCTT

AACATCCTCAATGGCTACGACTATCGTAAAGCTCTGGATGTGCGCGAATATGACA

ACAAGGAAGCGCGTCGTAACTGGACTAAAGTGGAGGGCATTCGCAAAATGAAGGA

AGGCTATCTGTCATTAGCGGTCTCGAAATTAGCGGATATGATTATCGAAAATAAC

GCCATCATCGTTATGGAGGACCTGAACCACGGATTCAAAGCGGGCCGCTCAAAGA

TTGAAAAACAAGTTTATCAGAAATTTGAGAGTATGCTGATTAACAAACTGGGCTA

TATGGTGTTAAAAGACAAGTCAATTGACCAATCAGGTGGCGCGCTGCATGGATAC

CAGCTGGCGAACCATGTTACCACCTTAGCATCAGTTGGAAAGCAGTGTGGGGTTA

TCTTTTATATACCGGCAGCGTTCACTAGTAAAATAGATCCGACCACTGGTTTCGC

CGATCTCTTTGCCCTGAGTAACGTTAAAAACGTAGCGAGCATGCGTGAATTCTTT

TCCAAAATGAAATCTGTCATTTATGATAAAGCTGAAGGCAAATTCGCATTCACCT

TTGATTACTTGGATTACAACGTGAAGAGCGAATGTGGTCGTACGCTGTGGACCGT

TTACACCGTTGGTGAGCGCTTCACCTATTCCCGTGTGAACCGCGAATATGTACGT

AAAGTCCCCACCGATATTATCTATGATGCCCTCCAGAAAGCAGGCATTAGCGTCG

AAGGAGACTTAAGGGACAGAATTGCCGAAAGCGATGGCGATACGCTGAAGTCTAT

TTTTTACGCATTCAAATACGCGCTAGATATGCGCGTTGAGAATCGCGAGGAAGAC

TACATTCAATCACCTGTGAAAAATGCCTCTGGGGAATTTTTTTGTTCAAAAAATG

CTGGTAAAAGCCTCCCACAAGATAGCGATGCAAACGGTGCATATAACATTGCCCT

GAAAGGTATTCTTCAATTACGCATGCTGTCTGAGCAGTACGACCCCAACGCGGAA

TCTATTAGACTTCCGCTGATAACCAATAAAGCCTGGCTGACATTCATGCAGTCTG

GCATGAAGACCTGGAAAAATTAG

SEQ
ATGGATAGTTTAAAAGATTTTACGAATCTATATCCCGTAAGCAAAACTCTTCGTT

ID
TTGAACTGAAACCTGTTGGAAAAACGTTGGAGAATATCGAGAAAGCGGGCATCCT

NO:
GAAAGAAGACGAGCACCGTGCCGAAAGCTACAGGCGTGTCAAAAAGATTATCGAT

46
ACTTATCACAAAGTGTTCATTGATAGCAGTCTGGAGAACATGGCAAAAATGGGCA

TAGAAAATGAAATCAAAGCAATGCTGCAGAGCTTTTGCGAGCTCTACAAGAAAGA

TCACCGAACGGAAGGTGAAGATAAAGCACTGGACAAAATTCGCGCCGTTCTTCGC

GGTCTGATTGTTGGCGCGTTCACCGGCGTGTGCGGCCGCCGTGAAAACACCGTGC

AGAACGAAAAGTACGAGTCGCTGTTCAAAGAAAAACTGATAAAAGAAATTTTGCC

TGACTTTGTGCTTTCGACCGAAGCGGAATCCCTGCCATTTTCTGTCGAAGAAGCG

ACCCGCAGCCTGAAAGAATTTGACTCATTCACAAGTTACTTTGCAGGCTTCTACG

AAAACCGTAAAAACATCTACAGCACGAAGCCACAGAGCACGGCTATTGCTTATCG

CCTGATTCATGAGAACCTGCCGAAGTTCATCGATAACATCCTTGTTTTTCAAAAA

ATTAAAGAGCCGATTGCGAAAGAGTTAGAACATATTCGAGCTGACTTTTCTGCGG

GTGGGTACATTAAAAAAGATGAGCGGCTGGAAGACATCTTCAGTCTAAACTATTA

TATCCACGTTCTGTCGCAGGCAGGCATTGAGAAATATAATGCGCTGATTGGTAAG

ATTGTCACAGAAGGCGATGGTGAGATGAAAGGTCTTAATGAACATATCAATCTGT

ATAACCAGCAGCGTGGTCGCGAAGACCGTCTTCCACTGTTCCGCCCACTGTATAA

ACAGATCCTGTCTGACCGGGAACAGCTGTCCTACCTGCCGGAAAGCTTTGAAAAG

GATGAAGAGCTACTTCGCGCATTAAAGGAGTTTTACGACCATATTGCGGAAGACA

TTTTGGGTAGAACGCAGCAACTGATGACGTCAATTTCTGAATACGATCTGAGTAG

AATCTACGTTAGGAATGATAGCCAGCTGACCGATATTAGCAAAAAAATGCTGGGC

GACTGGAACGCTATCTATATGGCACGTGAACGTGCATATGATCATGAACAAGCAC

CGAAACGTATAACCGCGAAATATGAGCGTGATCGCATTAAGGCGCTAAAGGGAGA

AGAAAGCATCTCACTCGCAAACCTGAACTCCTGTATCGCTTTCTTAGATAACGTG

CGCGATTGTCGCGTCGACACGTATCTGTCAACCCTTGGGCAGAAAGAGGGTCCAC

ATGGTCTGTCTAACCTGGTGGAAAATGTCTTTGCGAGTTACCATGAAGCGGAACA

ACTGCTGTCTTTTCCATACCCCGAAGAAAACAATCTAATACAGGATAAAGATAAC

GTGGTGTTAATCAAAAACCTGCTGGACAACATCAGCGATCTGCAACGTTTCCTGA

AACCTTTGTGGGGTATGGGTGACGAGCCAGACAAAGACGAACGTTTTTATGGTGA

GTATAATTATATACGTGGCGCCCTTGACCAAGTTATTCCGCTGTATAACAAAGTA

CGGAACTATCTGACCCGTAAGCCATATTCTACCCGTAAAGTGAAACTGAACTTTG

GCAACTCGCAACTGCTGTCGGGTTGGGATCGTAACAAAGAAAAAGATAATAGTTG

TGTTATCCTGCGTAAGGGACAAAATTTTTACCTCGCGATTATGAACAACAGACAC

AAGCGTTCATTTGAAAATAAGGTTCTGCCGGAGTATAAAGAGGGCGAACCGTACT

TCGAGAAAATGGATTATAAGTTCTTACCAGACCCTAATAAGATGTTACCGAAAGT

CTTTCTTTCGAAAAAAGGCATAGAAATCTATAAGCCGTCCCCGAAATTACTCGAA

CAGTATGGGCACGGGACCCACAAGAAAGGGGATACTTTTAGCATGGACGATCTGC

ACGAACTGATCGATTTTTTTAAACACTCCATCGAAGCCCATGAAGACTGGAAACA

GTTTGGGTTCAAGTTCTCTGATACAGCCACATACGAGAATGTGTCTAGTTTTTAT

CGGGAAGTGGAGGATCAGGGCTACAAACTTAGTTTTCGTAAAGTTTCAGAGAGTT

ATGTTTATAGTTTAATTGATCAGGGAAAACTTTACCTGTTCCAGATCTACAACAA

AGATTTCTCGCCATGTAGTAAGGGTACCCCGAATCTGCATACACTCTATTGGAGA

ATGTTATTCGATGAGCGTAACTTAGCGGATGTCATTTATAAATTGGACGGGAAAG

CAGAGATCTTTTTTCGTGAAAAATCACTGAAGAATGACCACCCGACTCATCCGGC

CGGGAAACCGATCAAAAAAAAATCCCGCCAGAAAAAAGGAGAAGAGTCTCTGTTT

GAATATGATCTGGTGAAAGACCGTCATTACACTATGGATAAATTTCAATTTCATG

TTCCAATTACAATGAACTTCAAATGTTCGGCGGGTTCCAAAGTAAATGATATGGT

AAACGCCCATATTCGCGAAGCGAAAGATATGCATGTTATTGGCATCGATAGAGGC

GAAAGAAACCTGCTTTATATTTGCGTAATTGACAGCCGTGGTACCATTCTGGACC

AGATCTCTTTAAACACCATCAATGACATCGATTATCACGACCTGTTGGAGTCTCG

GGACAAGGACCGCCAGCAGGAGCGCCGTAATTGGCAGACAATTGAAGGCATAAAA

GAATTAAAACAGGGTTACCTTTCCCAGGCCGTACACCGCATAGCGGAACTGATGG

TGGCCTACAAAGCCGTAGTTGCCCTGGAAGACTTGAATATGGGGTTTAAACGTGG

CCGTCAAAAAGTCGAGAGCAGCGTGTATCAGCAATTTGAAAAACAGTTGATTGAC

AAGTTGAATTATTTGGTTGATAAAAAGAAACGTCCAGAAGATATTGGTGGCTTAC

TGCGTGCATACCAGTTTACGGCACCTTTTAAGTCCTTCAAAGAAATGGGTAAACA

GAACGGGTTTCTGTTTTACATCCCGGCCTGGAATACATCCAACATCGATCCTACC

ACCGGGTTTGTCAACCTGTTTCATGCACAATATGAAAACGTGGATAAAGCGAAGA

GTTTTTTCCAAAAATTCGATAGTATTTCGTATAACCCAAAAAAAGATTGGTTTGA

GTTTGCGTTCGATTATAAAAATTTTACTAAAAAGGCTGAGGGATCCCGCAGTATG

TGGATCCTCTGCACCCATGGCAGTCGTATTAAAAATTTTCGTAATTCGCAAAAGA

ATGGCCAGTGGGACTCGGAAGAGTTTGCCCTGACCGAAGCGTTCAAATCGCTGTT

TGTACGCTACGAAATTGACTACACAGCAGATCTGAAAACAGCCATCGTCGATGAA

AAACAGAAAGATTTTTTTGTAGATCTCCTAAAACTGTTCAAACTGACTGTTCAGA

TGCGCAATTCCTGGAAAGAGAAAGACCTGGATTATCTGATTAGCCCGGTAGCCGG

TGCTGATGGACGATTTTTCGATACTCGTGAAGGTAACAAAAGTCTCCCGAAAGAT

GCTGATGCCAATGGTGCATACAATATTGCATTAAAGGGGCTATGGGCCTTGCGAC

AGATCCGCCAGACCAGCGAAGGCGGCAAGCTGAAATTGGCCATATCGAATAAGGA

ATGGTTACAATTTGTTCAGGAACGTAGCTATGAAAAAGATTGA

SEQ
ATGAACAACGGCACAAATAATTTTCAGAACTTCATCGGGATCTCAAGTTTGCAGA

ID
AAACGCTGCGCAATGCTCTGATCCCCACGGAAACCACGCAACAGTTCATCGTCAA

NO:
GAACGGAATAATTAAAGAAGATGAGTTACGTGGCGAGAACCGCCAGATTCTGAAA

47
GATATCATGGATGACTACTACCGCGGATTCATCTCTGAGACTCTGAGTTCTATTG

ATGACATAGATTGGACTAGCCTGTTCGAAAAAATGGAAATTCAGCTGAAAAATGG

TGATAATAAAGATACCTTAATTAAGGAACAGACAGAGTATCGGAAAGCAATCCAT

AAAAAATTTGCGAACGACGATCGGTTTAAGAACATGTTTAGCGCCAAACTGATTA

GTGACATATTACCTGAATTTGTCATCCACAACAATAATTATTCGGCATCAGAGAA

AGAGGAAAAAACCCAGGTGATAAAATTGTTTTCGCGCTTTGCGACTAGCTTTAAA

GATTACTTCAAGAACCGTGCAAATTGCTTTTCAGCGGACGATATTTCATCAAGCA

GCTGCCATCGCATCGTCAACGACAATGCAGAGATATTCTTTTCAAATGCGCTGGT

CTACCGCCGGATCGTAAAATCGCTGAGCAATGACGATATCAACAAAATTTCGGGC

GATATGAAAGATTCATTAAAAGAAATGAGTCTGGAAGAAATATATTCTTACGAGA

AGTATGGGGAATTTATTACCCAGGAAGGCATTAGCTTCTATAATGATATCTGTGG

GAAAGTGAATTCTTTTATGAACCTGTATTGTCAGAAAAATAAAGAAAACAAAAAT

TTATACAAACTTCAGAAACTTCACAAACAGATTCTATGCATTGCGGACACTAGCT

ATGAGGTCCCGTATAAATTTGAAAGTGACGAGGAAGTGTACCAATCAGTTAACGG

CTTCCTTGATAACATTAGCAGCAAACATATAGTCGAAAGATTACGCAAAATCGGC

GATAACTATAACGGCTACAACCTGGATAAAATTTATATCGTGTCCAAATTTTACG

AGAGCGTTAGCCAAAAAACCTACCGCGACTGGGAAACAATTAATACCGCCCTCGA

AATTCATTACAATAATATCTTGCCGGGTAACGGTAAAAGTAAAGCCGACAAAGTA

AAAAAAGCGGTTAAGAATGATTTACAGAAATCCATCACCGAAATAAATGAACTAG

TGTCAAACTATAAGCTGTGCAGTGACGACAACATCAAAGCGGAGACTTATATACA

TGAGATTAGCCATATCTTGAATAACTTTGAAGCACAGGAATTGAAATACAATCCG

GAAATTCACCTAGTTGAATCCGAGCTCAAAGCGAGTGAGCTTAAAAACGTGCTGG

ACGTGATCATGAATGCGTTTCATTGGTGTTCGGTTTTTATGACTGAGGAACTTGT

TGATAAAGACAACAATTTTTATGCGGAACTGGAGGAGATTTACGATGAAATTTAT

CCAGTAATTAGTCTGTACAACCTGGTTCGTAACTACGTTACCCAGAAACCGTACA

GCACGAAAAAGATTAAATTGAACTTTGGAATACCGACGTTAGCAGACGGTTGGTC

AAAGTCCAAAGAGTATTCTAATAACGCTATCATACTGATGCGCGACAATCTGTAT

TATCTGGGCATCTTTAATGCGAAGAATAAACCGGACAAGAAGATTATCGAGGGTA

ATACGTCAGAAAATAAGGGTGACTACAAAAAGATGATTTATAATTTGCTCCCGGG

TCCCAACAAAATGATCCCGAAAGTTTTCTTGAGCAGCAAGACGGGGGTGGAAACG

TATAAACCGAGCGCCTATATCCTAGAGGGGTATAAACAGAATAAACATATCAAGT

CTTCAAAAGACTTTGATATCACTTTCTGTCATGATCTGATCGACTACTTCAAAAA

CTGTATTGCAATTCATCCCGAGTGGAAAAACTTCGGTTTTGATTTTAGCGACACC

AGTACTTATGAAGACATTTCCGGGTTTTATCGTGAGGTAGAGTTACAAGGTTACA

AGATTGATTGGACATACATTAGCGAAAAAGACATTGATCTGCTGCAGGAAAAAGG

TCAACTGTATCTGTTCCAGATATATAACAAAGATTTTTCGAAAAAATCAACCGGG

AATGACAACCTTCACACCATGTACCTGAAAAATCTTTTCTCAGAAGAAAATCTTA

AGGATATCGTCCTGAAACTTAACGGCGAAGCGGAAATCTTCTTCAGGAAGAGCAG

CATAAAGAACCCAATCATTCATAAAAAAGGCTCGATTTTAGTCAACCGTACCTAC

GAAGCAGAAGAAAAAGACCAGTTTGGCAACATTCAAATTGTGCGTAAAAATATTC

CGGAAAACATTTATCAGGAGCTGTACAAATACTTCAACGATAAAAGCGACAAAGA

GCTGTCTGATGAAGCAGCCAAACTGAAGAATGTAGTGGGACACCACGAGGCAGCG

ACGAATATAGTCAAGGACTATCGCTACACGTATGATAAATACTTCCTTCATATGC

CTATTACGATCAATTTCAAAGCCAATAAAACGGGTTTTATTAATGATAGGATCTT

ACAGTATATCGCTAAAGAAAAAGACTTACATGTGATCGGCATTGATCGGGGCGAG

CGTAACCTGATCTACGTGTCCGTGATTGATACTTGTGGTAATATAGTTGAACAGA

AAAGCTTTAACATTGTAAACGGCTACGACTATCAGATAAAACTGAAACAACAGGA

GGGCGCTAGACAGATTGCGCGGAAAGAATGGAAAGAAATTGGTAAAATTAAAGAG

ATCAAAGAGGGCTACCTGAGCTTAGTAATCCACGAGATCTCTAAAATGGTAATCA

AATACAATGCAATTATAGCGATGGAGGATTTGTCTTATGGTTTTAAAAAAGGGCG

CTTTAAGGTCGAACGGCAAGTTTACCAGAAATTTGAAACCATGCTCATCAATAAA

CTCAACTATCTGGTATTTAAAGATATTTCGATTACCGAGAATGGCGGTCTCCTGA

AAGGTTATCAGCTGACATACATTCCTGATAAACTTAAAAACGTGGGTCATCAGTG

CGGCTGCATTTTTTATGTGCCTGCTGCATACACGAGCAAAATTGATCCGACCACC

GGCTTTGTGAATATCTTTAAATTTAAAGACCTGACAGTGGACGCAAAACGTGAAT

TCATTAAAAAATTTGACTCAATTCGTTATGACAGTGAAAAAAATCTGTTCTGCTT

TACATTTGACTACAATAACTTTATTACGCAAAACACGGTCATGAGCAAATCATCG

TGGAGTGTGTATACATACGGCGTGCGCATCAAACGTCGCTTTGTGAACGGCCGCT

TCTCAAACGAAAGTGATACCATTGACATAACCAAAGATATGGAGAAAACGTTGGA

AATGACGGACATTAACTGGCGCGATGGCCACGATCTTCGTCAAGACATTATAGAT

TATGAAATTGTTCAGCACATATTCGAAATTTTCCGTTTAACAGTGCAAATGCGTA

ACTCCTTGTCTGAACTGGAGGACCGTGATTACGATCGTCTCATTTCACCTGTACT

GAACGAAAATAACATTTTTTATGACAGCGCGAAAGCGGGGGATGCACTTCCTAAG

GATGCCGATGCAAATGGTGCGTATTGTATTGCATTAAAAGGGTTATATGAAATTA

AACAAATTACCGAAAATTGGAAAGAAGATGGTAAATTTTCGCGCGATAAACTCAA

AATCAGCAATAAAGATTGGTTCGACTTTATCCAGAATAAGCGCTATCTCTAA

SEQ
ATGACCAATAAATTCACTAACCAGTATTCTCTCTCTAAGACCCTGCGCTTTGAAC

ID
TGATTCCGCAGGGGAAAACCTTGGAGTTCATTCAAGAAAAAGGCCTCTTGTCTCA

NO:
GGATAAACAGAGGGCTGAATCTTACCAAGAAATGAAGAAAACTATTGATAAGTTT

48
CATAAATATTTCATTGATTTAGCCTTGTCTAACGCCAAATTAACTCACTTGGAAA

CGTATCTGGAGTTATACAACAAATCTGCCGAAACTAAGAAAGAACAGAAATTTAA

AGACGATTTGAAAAAAGTACAGGACAATCTGCGTAAAGAAATTGTCAAATCCTTC

AGTGACGGCGATGCTAAAAGCATTTTTGCCATTCTGGACAAAAAAGAGTTGATTA

CTGTGGAATTAGAAAAGTGGTTTGAAAACAATGAGCAGAAAGACATCTACTTCGA

TGAGAAATTCAAAACTTTCACCACCTATTTTACAGGATTTCATCAAAACCGGAAG

AACATGTACTCAGTAGAACCGAACTCCACGGCCATTGCGTATCGTTTGATCCATG

AGAATCTGCCTAAATTTCTGGAGAATGCGAAAGCCTTTGAAAAGATTAAGCAGGT

CGAATCGCTGCAAGTGAATTTTCGTGAACTCATGGGCGAATTTGGTGACGAAGGT

CTAATCTTCGTTAACGAACTGGAAGAAATGTTTCAGATTAATTACTACAATGACG

TGCTATCGCAGAACGGTATCACAATCTACAATAGTATTATCTCAGGGTTCACAAA

AAACGATATAAAATACAAAGGCCTGAACGAGTATATCAATAACTACAACCAAACA

AAGGACAAAAAGGATAGGCTTCCGAAACTGAAGCAGTTATACAAACAGATTTTAT

CTGACAGAATCTCCCTGAGCTTTCTGCCGGATGCTTTCACTGATGGGAAGCAGGT

TCTGAAAGCGATTTTCGATTTTTATAAGATTAACTTACTGAGCTACACGATTGAA

GGTCAAGAAGAATCTCAAAACTTACTGCTCTTGATCCGTCAAACCATTGAAAATC

TATCATCGTTCGATACGCAGAAAATCTACCTCAAAAACGATACTCACCTGACTAC

GATCTCTCAGCAGGTTTTCGGGGATTTTAGTGTATTTTCAACAGCTCTGAACTAC

TGGTATGAAACCAAAGTCAATCCGAAATTCGAGACGGAATATTCTAAGGCCAACG

AAAAAAAACGTGAGATTCTTGATAAAGCTAAAGCCGTATTTACTAAACAGGATTA

CTTTTCTATTGCTTTCCTGCAGGAAGTTTTATCGGAGTATATCCTGACCCTGGAT

CATACATCTGATATCGTTAAAAAACACAGCAGCAATTGCATCGCTGACTATTTCA

AAAACCACTTTGTCGCCAAAAAAGAAAACGAAACAGACAAGACTTTCGATTTCAT

TGCTAACATCACCGCAAAATACCAGTGTATTCAGGGTATCTTGGAAAACGCCGAC

CAATACGAAGACGAACTGAAACAAGATCAGAAGCTGATCGATAATTTAAAATTCT

TCTTAGATGCAATCCTGGAGCTGCTGCACTTCATCAAACCGCTTCATTTAAAGAG

CGAGTCCATTACCGAAAAGGACACCGCCTTCTATGACGTTTTTGAAAATTATTAT

GAAGCCCTCTCCTTGCTGACTCCGCTGTATAATATGGTACGCAATTACGTAACCC

AGAAACCATATTCTACCGAAAAAATTAAACTGAACTTTGAAAACGCACAGCTGCT

CAACGGTTGGGACGCGAATAAAGAAGGTGACTACCTCACCACCATCCTGAAAAAA

GATGGTAACTATTTTCTGGCAATTATGGATAAGAAACATAATAAAGCATTCCAGA

AATTTCCTGAAGGGAAAGAAAATTACGAAAAGATGGTGTACAAACTCTTACCTGG

AGTTAACAAAATGTTGCCGAAAGTATTTTTTAGTAATAAGAACATCGCGTACTTT

AACCCGTCCAAAGAACTGCTGGAAAATTATAAAAAGGAGACGCATAAGAAAGGGG

ATACCTTTAACCTGGAACATTGCCATACCTTAATAGACTTCTTCAAGGATTCCCT

GAATAAACACGAGGATTGGAAATATTTCGATTTTCAGTTTAGTGAGACCAAGTCA

TACCAGGATCTTAGCGGCTTTTATCGCGAAGTAGAACACCAAGGCTATAAAATTA

ACTTCAAAAACATCGACAGCGAATACATCGACGGTTTAGTTAACGAGGGCAAACT

GTTTCTGTTCCAGATCTATTCAAAGGATTTTAGCCCGTTCTCTAAAGGCAAACCA

AATATGCATACGTTGTACTGGAAAGCACTGTTTGAAGAGCAAAACCTGCAGAATG

TGATTTATAAACTGAACGGCCAAGCTGAGATTTTTTTCCGTAAAGCCTCGATTAA

ACCGAAAAATATCATCCTTCATAAGAAGAAAATAAAGATCGCTAAAAAACACTTC

ATAGATAAAAAAACCAAAACCTCCGAAATAGTGCCTGTTCAAACAATTAAGAACT

TGAATATGTACTACCAGGGCAAGATATCGGAAAAGGAGTTGACTCAAGACGATCT

TCGCTATATCGATAACTTTTCGATTTTTAACGAAAAAAACAAGACGATCGACATC

ATCAAAGATAAACGCTTCACTGTAGATAAGTTCCAGTTTCATGTGCCGATTACTA

TGAACTTCAAAGCTACCGGGGGTAGCTATATCAACCAAACGGTGTTGGAATACCT

GCAGAATAACCCGGAAGTCAAAATCATTGGGCTGGACCGCGGAGAACGTCACCTT

GTGTACTTGACCTTAATCGATCAGCAAGGCAACATCTTAAAACAAGAATCGCTGA

ATACCATTACGGATTCAAAGATTAGCACCCCGTATCATAAGCTGCTCGATAACAA

GGAGAATGAGCGCGACCTGGCCCGTAAAAACTGGGGCACGGTGGAAAACATTAAG

GAGTTAAAGGAGGGTTATATTTCCCAGGTAGTGCATAAGATCGCCACTCTCATGC

TCGAGGAAAATGCGATCGTTGTCATGGAAGACTTAAACTTCGGATTTAAACGTGG

GCGATTTAAAGTAGAGAAACAAATCTACCAGAAGTTAGAAAAAATGCTGATTGAC

AAATTAAATTACTTGGTCCTAAAAGACAAACAGCCGCAAGAATTGGGTGGATTAT

ACAACGCCCTCCAACTTACCAATAAATTCGAAAGTTTTCAGAAAATGGGTAAACA

GTCAGGCTTTCTTTTTTATGTTCCTGCGTGGAACACATCCAAAATCGACCCTACA

ACCGGCTTCGTCAATTACTTCTATACTAAATATGAAAACGTCGACAAAGCAAAAG

CATTCTTTGAAAAGTTCGAAGCAATACGTTTTAACGCTGAGAAAAAATATTTCGA

GTTCGAAGTCAAGAAATACTCAGACTTTAACCCCAAAGCTGAGGGCACACAGCAA

GCGTGGACAATCTGCACCTACGGCGAGCGCATCGAAACGAAGCGTCAAAAAGATC

AGAATAACAAATTTGTTTCAACACCTATCAACCTGACCGAGAAGATTGAAGACTT

CTTAGGTAAAAATCAGATTGTTTATGGCGACGGTAACTGTATAAAATCTCAAATA

GCCTCAAAGGATGATAAAGCATTTTTCGAAACATTATTATATTGGTTCAAAATGA

CACTGCAGATGCGCAATAGTGAGACGCGTACAGATATTGATTATCTTATCAGCCC

GGTCATGAACGACAACGGTACTTTTTACAACTCCAGAGACTATGAAAAACTTGAG

AATCCAACTCTCCCCAAAGATGCTGATGCGAACGGTGCTTATCACATCGCGAAAA

AAGGTCTGATGCTGCTGAACAAAATCGACCAAGCCGATCTGACTAAGAAAGTTGA

CCTAAGCATTTCAAATCGGGACTGGTTACAGTTTGTTCAAAAGAACAAATGA

SEQ
ATGGAACAGGAATATTATCTGGGCTTGGACATGGGCACCGGTTCCGTCGGCTGGG

ID
CTGTTACTGACAGTGAATATCACGTTCTAAGAAAGCATGGTAAGGCATTGTGGGG

NO:
TGTAAGACTTTTCGAATCTGCTTCCACTGCTGAAGAGCGTAGAATGTTTAGAACG

49
AGTCGACGTAGGCTAGACAGGCGCAATTGGAGAATCGAAATTTTACAAGAAATTT

TTGCGGAAGAGATATCTAAGAAAGACCCAGGCTTTTTCCTGAGAATGAAGGAATC

TAAGTATTACCCTGAGGATAAAAGAGATATAAATGGTAACTGTCCCGAATTGCCT

TACGCATTATTTGTGGACGATGATTTTACCGATAAGGATTACCATAAAAAGTTCC

CAACTATCTACCATTTACGCAAAATGTTAATGAATACAGAGGAAACCCCAGACAT

AAGACTAGTTTATCTGGCAATACACCATATGATGAAACATAGAGGCCATTTCTTA

CTTTCCGGGGATATCAACGAAATCAAAGAGTTTGGTACCACATTTAGTAAGTTAC

TGGAAAACATAAAGAATGAAGAATTGGATTGGAACTTAGAACTCGGAAAAGAAGA

ATACGCGGTTGTCGAATCTATCCTGAAGGATAATATGCTGAATAGGTCGACCAAA

AAAACTAGGCTGATCAAAGCACTGAAAGCCAAATCTATCTGCGAAAAAGCTGTTT

TAAATTTACTTGCTGGTGGCACTGTTAAGTTATCAGACATTTTTGGTTTGGAAGA

ATTGAACGAAACCGAGCGTCCAAAAATTAGTTTCGCTGATAATGGCTACGATGAT

TACATTGGTGAGGTGGAAAACGAGTTGGGCGAACAATTTTATATTATAGAGACAG

CTAAGGCAGTCTATGACTGGGCTGTTTTAGTAGAAATCCTTGGTAAATACACATC

TATCTCCGAAGCGAAAGTTGCTACTTACGAAAAGCACAAGTCCGATCTCCAGTTT

TTGAAGAAAATTGTCAGGAAATATCTGACTAAGGAAGAATATAAAGATATTTTCG

TTAGTACCTCTGACAAACTGAAAAATTACTCCGCTTACATCGGGATGACCAAGAT

TAATGGCAAAAAAGTTGATCTGCAAAGCAAAAGGTGTTCGAAGGAAGAATTTTAT

GATTTCATTAAAAAGAATGTCTTAAAAAAATTAGAAGGTCAGCCAGAATACGAAT

ATTTGAAAGAAGAACTGGAAAGAGAGACATTCTTACCAAAACAAGTCAACAGAGA

TAATGGGGTAATTCCATATCAAATTCACCTCTACGAATTAAAAAAAATTTTAGGC

AATTTACGCGATAAAATTGACCTTATCAAAGAAAATGAGGATAAGCTGGTTCAAC

TCTTTGAATTCAGAATACCCTATTATGTGGGCCCACTGAACAAGATTGATGACGG

CAAAGAAGGTAAATTCACATGGGCCGTCCGCAAATCCAATGAAAAAATTTACCCA

TGGAACTTTGAAAATGTAGTAGATATTGAAGCGTCTGCGGAGAAATTTATTCGAA

GAATGACTAATAAATGCACTTACTTGATGGGAGAGGATGTTCTGCCTAAAGACAG

CTTATTATACAGCAAGTACATGGTTCTAAACGAACTTAACAACGTTAAGTTGGAC

GGTGAGAAATTAAGTGTAGAATTGAAACAAAGATTGTATACTGACGTCTTCTGCA

AGTACAGAAAAGTGACAGTTAAAAAAATTAAGAATTACTTGAAGTGCGAAGGTAT

AATTTCTGGAAACGTAGAGATTACTGGTATTGATGGTGATTTCAAAGCATCCCTA

ACAGCTTACCACGATTTCAAGGAAATCCTGACAGGAACTGAACTCGCAAAAAAAG

ATAAAGAAAACATTATTACTAATATTGTTCTTTTCGGTGATGACAAGAAATTGTT

GAAGAAAAGACTGAATAGACTTTACCCCCAGATTACTCCCAATCAACTTAAGAAA

ATTTGTGCTTTGTCTTACACAGGATGGGGTCGTTTTTCAAAAAAGTTCTTAGAAG

AGATTACCGCACCTGATCCAGAAACAGGCGAAGTATGGAATATAATTACCGCCTT

ATGGGAATCGAACAATAATCTTATGCAACTTCTGAGCAATGAATATCGTTTCATG

GAAGAAGTTGAGACTTACAACATGGGCAAACAGACGAAGACTTTATCCTATGAAA

CTGTGGAAAATATGTATGTATCACCTTCTGTCAAGAGACAAATTTGGCAAACCTT

AAAAATTGTCAAAGAATTAGAAAAGGTAATGAAGGAGTCTCCTAAACGTGTGTTT

ATTGAAATGGCTAGAGAAAAACAAGAGTCAAAAAGAACCGAGTCAAGAAAGAAGC

AGTTAATCGATTTATATAAGGCTTGTAAAAACGAAGAGAAAGATTGGGTTAAAGA

ATTGGGGGACCAAGAGGAACAAAAACTACGGTCGGATAAGTTGTATTTATACTAT

ACGCAAAAGGGACGATGTATGTATTCCGGCGAGGTAATAGAATTGAAGGATTTAT

GGGACAATACAAAATATGACATAGACCATATATATCCCCAATCAAAAACGATGGA

CGATAGCTTGAACAATAGAGTACTCGTGAAAAAAAAATATAATGCGACCAAATCT

GATAAGTATCCTCTGAATGAAAATATCAGACATGAAAGAAAGGGGTTCTGGAAGT

CCTTGTTAGATGGTGGGTTTATAAGCAAAGAAAAGTACGAGCGTCTAATAAGAAA

CACGGAGTTATCGCCAGAAGAACTCGCTGGTTTTATTGAGAGGCAAATCGTGGAA

ACGAGACAATCTACCAAAGCCGTTGCTGAGATCCTAAAGCAAGTTTTCCCAGAGT

CGGAGATTGTCTATGTCAAAGCTGGCACAGTGAGCAGGTTTAGGAAAGACTTCGA

ACTATTAAAGGTAAGAGAAGTGAACGATTTACATCACGCAAAGGACGCTTACCTA

AATATCGTTGTAGGTAACTCATATTATGTTAAATTTACCAAGAACGCCTCTTGGT

TTATAAAGGAGAACCCAGGTAGAACATATAACCTGAAAAAGATGTTCACCTCTGG

TTGGAATATTGAGAGAAACGGAGAAGTCGCATGGGAAGTTGGTAAGAAAGGGACT

ATAGTGACAGTAAAGCAAATTATGAACAAAAATAATATCCTCGTTACAAGGCAGG

TTCATGAAGCAAAGGGCGGCCTTTTTGACCAACAAATTATGAAGAAAGGGAAAGG

TCAAATTGCAATAAAAGAAACCGATGAGAGACTAGCGTCAATAGAAAAGTATGGT

GGCTATAATAAAGCTGCGGGTGCATACTTTATGCTTGTTGAATCAAAAGACAAGA

AAGGTAAGACTATTAGAACTATAGAATTTATACCCCTGTACCTTAAAAACAAAAT

TGAATCGGATGAGTCAATCGCGTTAAATTTTCTAGAGAAAGGAAGGGGTTTAAAA

GAACCAAAGATCCTGTTAAAAAAGATTAAGATTGACACCTTGTTCGATGTAGATG

GATTTAAAATGTGGTTATCTGGCAGAACAGGCGATAGACTTTTGTTTAAGTGCGC

TAATCAATTAATTTTGGATGAGAAAATCATTGTCACAATGAAAAAAATAGTTAAG

TTTATTCAGAGAAGACAAGAAAACAGGGAGTTGAAATTATCTGATAAAGATGGTA

TCGACAATGAAGTTTTAATGGAAATCTACAATACATTCGTTGATAAACTTGAAAA

TACCGTATATCGAATCAGGTTAAGTGAACAAGCCAAAACATTAATTGATAAACAA

AAAGAATTTGAAAGGCTATCACTGGAAGACAAATCCTCCACCCTATTTGAAATTT

TGCATATATTCCAGTGCCAATCTTCAGCAGCTAATTTAAAAATGATTGGCGGACC

TGGGAAAGCCGGCATCCTAGTGATGAACAATAATATCTCCAAGTGTAACAAAATA

TCAATTATTAACCAATCTCCGACAGGTATTTTTGAAAATGAAATAGACTTGCTTA

AGATATAA

SEQ
ATGTCTTTCGACTCTTTCACCAACCTGTACTCTCTGTCTAAAACCCTGAAATTCG

ID
AAATGCGTCCGGTTGGTAACACCCAGAAAATGCTGGACAACGCGGGTGTTTTCGA

NO:
AAAAGACAAACTGATCCAGAAAAAATACGGTAAAACCAAACCGTACTTCGACCGT

50
CTGCACCGTGAATTCATCGAAGAAGCGCTGACCGGTGTTGAACTGATCGGTCTGG

ACGAAAACTTCCGTACCCTGGTTGACTGGCAGAAAGACAAAAAAAACAACGTTGC

GATGAAAGCGTACGAAAACTCTCTGCAGCGTCTGCGTACCGAAATCGGTAAAATC

TTCAACCTGAAAGCGGAAGACTGGGTTAAAAACAAATACCCGATCCTGGGTCTGA

AAAACAAAAACACCGACATCCTGTTCGAAGAAGCGGTTTTCGGTATCCTGAAAGC

GCGTTACGGTGAAGAAAAAGACACCTTCATCGAAGTTGAAGAAATCGACAAAACC

GGTAAATCTAAAATCAACCAGATCTCTATCTTCGACTCTTGGAAAGGTTTCACCG

GTTACTTCAAAAAATTCTTCGAAACCCGTAAAAACTTCTACAAAAACGACGGTAC

CTCTACCGCGATCGCGACCCGTATCATCGACCAGAACCTGAAACGTTTCATCGAC

AACCTGTCTATCGTTGAATCTGTTCGTCAGAAAGTTGACCTGGCGGAAACCGAAA

AATCTTTCTCTATCTCTCTGTCTCAGTTCTTCTCTATCGACTTCTACAACAAATG

CCTGCTGCAGGACGGTATCGACTACTACAACAAAATCATCGGTGGTGAAACCCTG

AAAAACGGTGAAAAACTGATCGGTCTGAACGAACTGATCAACCAGTACCGTCAGA

ACAACAAAGACCAGAAAATCCCGTTCTTCAAACTGCTGGACAAACAGATCCTGTC

TGAAAAAATCCTGTTCCTGGACGAAATCAAAAACGACACCGAACTGATCGAAGCG

CTGTCTCAGTTCGCGAAAACCGCGGAAGAAAAAACCAAAATCGTTAAAAAACTGT

TCGCGGACTTCGTTGAAAACAACTCTAAATACGACCTGGCGCAGATCTACATCTC

TCAGGAAGCGTTCAACACCATCTCTAACAAATGGACCTCTGAAACCGAAACCTTC

GCGAAATACCTGTTCGAAGCGATGAAATCTGGTAAACTGGCGAAATACGAAAAAA

AAGACAACTCTTACAAATTCCCGGACTTCATCGCGCTGTCTCAGATGAAATCTGC

GCTGCTGTCTATCTCTCTGGAAGGTCACTTCTGGAAAGAAAAATACTACAAAATC

TCTAAATTCCAGGAAAAAACCAACTGGGAACAGTTCCTGGCGATCTTCCTGTACG

AATTCAACTCTCTGTTCTCTGACAAAATCAACACCAAAGACGGTGAAACCAAACA

GGTTGGTTACTACCTGTTCGCGAAAGACCTGCACAACCTGATCCTGTCTGAACAG

ATCGACATCCCGAAAGACTCTAAAGTTACCATCAAAGACTTCGCGGACTCTGTTC

TGACCATCTACCAGATGGCGAAATACTTCGCGGTTGAAAAAAAACGTGCGTGGCT

GGCGGAATACGAACTGGACTCTTTCTACACCCAGCCGGACACCGGTTACCTGCAG

TTCTACGACAACGCGTACGAAGACATCGTTCAGGTTTACAACAAACTGCGTAACT

ACCTGACCAAAAAACCGTACTCTGAAGAAAAATGGAAACTGAACTTCGAAAACTC

TACCCTGGCGAACGGTTGGGACAAAAACAAAGAATCTGACAACTCTGCGGTTATC

CTGCAGAAAGGTGGTAAATACTACCTGGGTCTGATCACCAAAGGTCACAACAAAA

TCTTCGACGACCGTTTCCAGGAAAAATTCATCGTTGGTATCGAAGGTGGTAAATA

CGAAAAAATCGTTTACAAATTCTTCCCGGACCAGGCGAAAATGTTCCCGAAAGTT

TGCTTCTCTGCGAAAGGTCTGGAATTCTTCCGTCCGTCTGAAGAAATCCTGCGTA

TCTACAACAACGCGGAATTCAAAAAAGGTGAAACCTACTCTATCGACTCTATGCA

GAAACTGATCGACTTCTACAAAGACTGCCTGACCAAATACGAAGGTTGGGCGTGC

TACACCTTCCGTCACCTGAAACCGACCGAAGAATACCAGAACAACATCGGTGAAT

TCTTCCGTGACGTTGCGGAAGACGGTTACCGTATCGACTTCCAGGGTATCTCTGA

CCAGTACATCCACGAAAAAAACGAAAAAGGTGAACTGCACCTGTTCGAAATCCAC

AACAAAGACTGGAACCTGGACAAAGCGCGTGACGGTAAATCTAAAACCACCCAGA

AAAACCTGCACACCCTGTACTTCGAATCTCTGTTCTCTAACGACAACGTTGTTCA

GAACTTCCCGATCAAACTGAACGGTCAGGCGGAAATCTTCTACCGTCCGAAAACC

GAAAAAGACAAACTGGAATCTAAAAAAGACAAAAAAGGTAACAAAGTTATCGACC

ACAAACGTTACTCTGAAAACAAAATCTTCTTCCACGTTCCGCTGACCCTGAACCG

TACCAAAAACGACTCTTACCGTTTCAACGCGCAGATCAACAACTTCCTGGCGAAC

AACAAAGACATCAACATCATCGGTGTTGACCGTGGTGAAAAACACCTGGTTTACT

ACTCTGTTATCACCCAGGCGTCTGACATCCTGGAATCTGGTTCTCTGAACGAACT

GAACGGTGTTAACTACGCGGAAAAACTGGGTAAAAAAGCGGAAAACCGTGAACAG

GCGCGTCGTGACTGGCAGGACGTTCAGGGTATCAAAGACCTGAAAAAAGGTTACA

TCTCTCAGGTTGTTCGTAAACTGGCGGACCTGGCGATCAAACACAACGCGATCAT

CATCCTGGAAGACCTGAACATGCGTTTCAAACAGGTTCGTGGTGGTATCGAAAAA

TCTATCTACCAGCAGCTGGAAAAAGCGCTGATCGACAAACTGTCTTTCCTGGTTG

ACAAAGGTGAAAAAAACCCGGAACAGGCGGGTCACCTGCTGAAAGCGTACCAGCT

GTCTGCGCCGTTCGAAACCTTCCAGAAAATGGGTAAACAGACCGGTATCATCTTC

TACACCCAGGCGTCTTACACCTCTAAATCTGACCCGGTTACCGGTTGGCGTCCGC

ACCTGTACCTGAAATACTTCTCTGCGAAAAAAGCGAAAGACGACATCGCGAAATT

CACCAAAATCGAATTCGTTAACGACCGTTTCGAACTGACCTACGACATCAAAGAC

TTCCAGCAGGCGAAAGAATACCCGAACAAAACCGTTTGGAAAGTTTGCTCTAACG

TTGAACGTTTCCGTTGGGACAAAAACCTGAACCAGAACAAAGGTGGTTACACCCA

CTACACCAACATCACCGAAAACATCCAGGAACTGTTCACCAAATACGGTATCGAC

ATCACCAAAGACCTGCTGACCCAGATCTCTACCATCGACGAAAAACAGAACACCT

CTTTCTTCCGTGACTTCATCTTCTACTTCAACCTGATCTGCCAGATCCGTAACAC

CGACGACTCTGAAATCGCGAAAAAAAACGGTAAAGACGACTTCATCCTGTCTCCG

GTTGAACCGTTCTTCGACTCTCGTAAAGACAACGGTAACAAACTGCCGGAAAACG

GTGACGACAACGGTGCGTACAACATCGCGCGTAAAGGTATCGTTATCCTGAACAA

AATCTCTCAGTACTCTGAAAAAAACGAAAACTGCGAAAAAATGAAATGGGGTGAC

CTGTACGTTTCTAACATCGACTGGGACAACTTCGTT

SEQ
ATGGAAAACTTTAAAAACTTATACCCAATAAACAAAACGTTACGTTTTGAACTGC

ID
GTCCATATGGTAAAACACTGGAAAACTTTAAAAAAAGCGGTTTGTTGGAGAAGGA

NO:
TGCATTTAAAGCGAACTCTCGCAGATCCATGCAGGCCATCATTGATGAAAAATTT

51
AAAGAGACGATCGAAGAACGTCTGAAATACACGGAATTTAGTGAGTGTGACTTAG

GTAATATGACTTCTAAAGATAAGAAAATCACCGATAAGGCGGCGACCAACCTGAA

GAAGCAAGTCATTTTATCTTTTGATGATGAAATCTTTAACAACTATTTGAAACCG

GACAAAAACATCGATGCCTTATTTAAAAATGACCCTTCGAACCCGGTGATTAGCA

CATTTAAGGGCTTCACAACGTATTTTGTCAATTTTTTTGAAATTCGTAAACATAT

CTTCAAAGGAGAATCAAGCGGCTCTATGGCTTATCGCATTATTGATGAAAACCTG

ACGACCTATTTGAATAACATTGAAAAAATCAAAAAACTGCCAGAGGAATTAAAGT

CTCAGTTAGAAGGCATCGACCAGATCGACAAACTCAACAACTATAACGAATTTAT

TACGCAGTCTGGTATCACCCACTATAATGAAATTATTGGAGGTATCAGTAAATCA

GAAAATGTGAAAATCCAAGGGATTAATGAAGGCATTAACCTCTATTGCCAGAAAA

ATAAAGTGAAACTGCCGAGGCTGACTCCACTCTACAAAATGATCCTGTCTGACCG

CGTCTCGAATAGCTTTGTCCTGGACACAATTGAAAACGATACGGAATTGATTGAG

ATGATAAGCGATCTGATTAACAAAACCGAAATTTCACAGGATGTAATCATGAGTG

ATATACAAAACATCTTTATTAAATATAAACAGCTTGGTAATCTGCCTGGAATTAG

CTATTCGTCAATAGTGAACGCAATCTGTTCTGATTATGATAACAATTTTGGCGAC

GGTAAGCGTAAAAAGAGTTATGAAAACGATAGGAAAAAACACCTGGAAACTAACG

TGTATTCTATCAACTATATCAGCGAACTGCTTACGGACACCGATGTGAGTTCAAA

CATTAAGATGCGGTATAAGGAGCTTGAACAGAACTACCAGGTCTGTAAGGAAAAC

TTCAACGCAACCAACTGGATGAACATTAAAAATATCAAACAATCCGAGAAGACCA

ACTTAATCAAAGATCTGCTGGATATTTTGAAGAGCATTCAACGTTTTTATGATCT

GTTCGATATCGTTGATGAAGACAAGAATCCTAGTGCGGAATTTTATACATGGCTG

TCTAAAAATGCGGAGAAATTGGATTTCGAATTCAATTCTGTTTATAATAAATCAC

GCAACTATTTGACCCGCAAACAATACAGCGACAAAAAGATAAAACTAAACTTCGA

CAGTCCGACATTGGCAAAGGGCTGGGACGCAAATAAGGAAATCGATAACTCTACG

ATAATTATGCGTAAGTTCAATAATGATCGAGGTGATTATGATTATTTCTTAGGCA

TTTGGAACAAAAGCACCCCGGCCAACGAAAAGATAATTCCACTGGAGGATAACGG

TCTGTTCGAAAAAATGCAGTACAAATTATATCCGGATCCAAGCAAGATGCTTCCA

AAGCAGTTTCTGTCTAAAATTTGGAAAGCTAAGCATCCGACCACCCCAGAATTTG

ACAAGAAATATAAGGAAGGCCGCCATAAGAAAGGTCCCGATTTTGAAAAAGAATT

CTTGCACGAACTGATTGATTGCTTTAAACATGGCTTAGTCAATCACGATGAAAAG

TATCAAGATGTTTTTGGATTCAATTTGAGAAACACAGAAGACTACAATTCCTACA

CTGAGTTTCTCGAAGATGTGGAACGATGTAATTATAATCTGAGCTTTAACAAAAT

CGCGGACACCTCGAATCTGATTAACGATGGTAAACTTTATGTTTTCCAGATCTGG

AGCAAGGATTTCTCTATTGACAGCAAAGGCACCAAAAACCTGAACACCATTTACT

TTGAAAGTCTCTTCAGCGAAGAAAATATGATTGAGAAAATGTTTAAACTTAGCGG

TGAAGCTGAAATATTCTATCGCCCGGCAAGCCTGAACTATTGCGAAGACATTATC

AAAAAGGGTCATCACCACGCTGAACTGAAAGATAAATTTGATTATCCTATCATAA

AAGATAAACGCTATAGCCAGGATAAATTTTTTTTTCATGTTCCTATGGTCATTAA

CTACAAATCAGAAAAACTGAACTCTAAAAGCCTCAATAATCGAACCAATGAAAAC

CTTGGGCAGTTTACCCATATAATTGGAATTGATCGCGGAGAGCGTCATTTAATCT

ACCTGACCGTAGTCGATGTATCGACCGGCGAGATCGTCGAGCAGAAGCACTTAGA

CGAGATTATCAACACTGATACCAAAGGTGTTGAGCATAAGACGCACTATCTAAAC

AAGCTGGAGGAAAAATCGAAAACCCGTGATAATGAACGTAAGAGTTGGGAGGCAA

TTGAAACGATTAAAGAACTGAAGGAGGGTTATATCAGCCACGTAATCAATGAAAT

TCAAAAACTGCAGGAAAAATACAACGCCCTGATCGTTATGGAAAATCTGAATTAC

GGTTTCAAAAATTCTCGCATCAAAGTGGAAAAACAGGTATATCAGAAGTTCGAGA

CGGCATTAATTAAAAAGTTTAATTACATCATTGACAAAAAAGATCCGGAAACTTA

TATTCATGGCTATCAGCTGACGAACCCGATCACCACACTGGATAAAATTGGTAAC

CAGTCTGGTATCGTGCTTTACATCCCTGCCTGGAATACCAGTAAAATCGATCCGG

TAACGGGATTCGTCAACCTTCTATATGCAGATGACCTCAAATATAAGAATCAGGA

ACAGGCCAAGTCTTTTATTCAGAAAATCGATAACATTTACTTTGAGAATGGGGAA

TTCAAATTTGATATTGATTTTTCTAAATGGAACAATCGTTATAGTATATCTAAGA

CGAAATGGACGCTCACCTCGTACGGAACCCGAATCCAGACATTCCGCAATCCGCA

GAAGAACAATAAATGGGACAGCGCCGAGTATGATCTCACTGAAGAATTCAAATTG

ATTCTGAACATTGACGGTACCCTGAAAAGCCAGGATGTCGAAACCTATAAAAAAT

TTATGTCTCTGTTCAAGCTGATGCTGCAACTTAGGAACTCTGTTACCGGCACTGA

TATCGATTATATGATCTCCCCTGTCACTGATAAAACAGGTACGCATTTCGATTCG

CGCGAAAATATCAAAAATCTGCCCGCAGATGCCGACGCCAATGGGGCGTACAATA

TTGCACGCAAGGGTATCATGGCGATCGAAAACATTATGAATGGTATCAGCGACCC

GCTGAAAATCTCAAACGAAGATTATTTGAAATATATCCAAAACCAGCAGGAATAA

SEQ
ATGACCCAGTTCGAAGGTTTCACCAACCTGTACCAGGTTTCTAAAACCCTGCGTT

ID
TCGAACTGATCCCGCAGGGTAAAACCCTGAAACACATCCAGGAACAGGGTTTCAT

NO:
CGAAGAAGACAAAGCGCGTAACGACCACTACAAAGAACTGAAACCGATCATCGAC

52
CGTATCTACAAAACCTACGCGGACCAGTGCCTGCAGCTGGTTCAGCTGGACTGGG

AAAACCTGTCTGCGGCGATCGACTCTTACCGTAAAGAAAAAACCGAAGAAACCCG

TAACGCGCTGATCGAAGAACAGGCGACCTACCGTAACGCGATCCACGACTACTTC

ATCGGTCGTACCGACAACCTGACCGACGCGATCAACAAACGTCACGCGGAAATCT

ACAAAGGTCTGTTCAAAGCGGAACTGTTCAACGGTAAAGTTCTGAAACAGCTGGG

TACCGTTACCACCACCGAACACGAAAACGCGCTGCTGCGTTCTTTCGACAAATTC

ACCACCTACTTCTCTGGTTTCTACGAAAACCGTAAAAACGTTTTCTCTGCGGAAG

ACATCTCTACCGCGATCCCGCACCGTATCGTTCAGGACAACTTCCCGAAATTCAA

AGAAAACTGCCACATCTTCACCCGTCTGATCACCGCGGTTCCGTCTCTGCGTGAA

CACTTCGAAAACGTTAAAAAAGCGATCGGTATCTTCGTTTCTACCTCTATCGAAG

AAGTTTTCTCTTTCCCGTTCTACAACCAGCTGCTGACCCAGACCCAGATCGACCT

GTACAACCAGCTGCTGGGTGGTATCTCTCGTGAAGCGGGTACCGAAAAAATCAAA

GGTCTGAACGAAGTTCTGAACCTGGCGATCCAGAAAAACGACGAAACCGCGCACA

TCATCGCGTCTCTGCCGCACCGTTTCATCCCGCTGTTCAAACAGATCCTGTCTGA

CCGTAACACCCTGTCTTTCATCCTGGAAGAATTCAAATCTGACGAAGAAGTTATC

CAGTCTTTCTGCAAATACAAAACCCTGCTGCGTAACGAAAACGTTCTGGAAACCG

CGGAAGCGCTGTTCAACGAACTGAACTCTATCGACCTGACCCACATCTTCATCTC

TCACAAAAAACTGGAAACCATCTCTTCTGCGCTGTGCGACCACTGGGACACCCTG

CGTAACGCGCTGTACGAACGTCGTATCTCTGAACTGACCGGTAAAATCACCAAAT

CTGCGAAAGAAAAAGTTCAGCGTTCTCTGAAACACGAAGACATCAACCTGCAGGA

AATCATCTCTGCGGCGGGTAAAGAACTGTCTGAAGCGTTCAAACAGAAAACCTCT

GAAATCCTGTCTCACGCGCACGCGGCGCTGGACCAGCCGCTGCCGACCACCCTGA

AAAAACAGGAAGAAAAAGAAATCCTGAAATCTCAGCTGGACTCTCTGCTGGGTCT

GTACCACCTGCTGGACTGGTTCGCGGTTGACGAATCTAACGAAGTTGACCCGGAA

TTCTCTGCGCGTCTGACCGGTATCAAACTGGAAATGGAACCGTCTCTGTCTTTCT

ACAACAAAGCGCGTAACTACGCGACCAAAAAACCGTACTCTGTTGAAAAATTCAA

ACTGAACTTCCAGATGCCGACCCTGGCGTCTGGTTGGGACGTTAACAAAGAAAAA

AACAACGGTGCGATCCTGTTCGTTAAAAACGGTCTGTACTACCTGGGTATCATGC

CGAAACAGAAAGGTCGTTACAAAGCGCTGTCTTTCGAACCGACCGAAAAAACCTC

TGAAGGTTTCGACAAAATGTACTACGACTACTTCCCGGACGCGGCGAAAATGATC

CCGAAATGCTCTACCCAGCTGAAAGCGGTTACCGCGCACTTCCAGACCCACACCA

CCCCGATCCTGCTGTCTAACAACTTCATCGAACCGCTGGAAATCACCAAAGAAAT

CTACGACCTGAACAACCCGGAAAAAGAACCGAAAAAATTCCAGACCGCGTACGCG

AAAAAAACCGGTGACCAGAAAGGTTACCGTGAAGCGCTGTGCAAATGGATCGACT

TCACCCGTGACTTCCTGTCTAAATACACCAAAACCACCTCTATCGACCTGTCTTC

TCTGCGTCCGTCTTCTCAGTACAAAGACCTGGGTGAATACTACGCGGAACTGAAC

CCGCTGCTGTACCACATCTCTTTCCAGCGTATCGCGGAAAAAGAAATCATGGACG

CGGTTGAAACCGGTAAACTGTACCTGTTCCAGATCTACAACAAAGACTTCGCGAA

AGGTCACCACGGTAAACCGAACCTGCACACCCTGTACTGGACCGGTCTGTTCTCT

CCGGAAAACCTGGCGAAAACCTCTATCAAACTGAACGGTCAGGCGGAACTGTTCT

ACCGTCCGAAATCTCGTATGAAACGTATGGCGCACCGTCTGGGTGAAAAAATGCT

GAACAAAAAACTGAAAGACCAGAAAACCCCGATCCCGGACACCCTGTACCAGGAA

CTGTACGACTACGTTAACCACCGTCTGTCTCACGACCTGTCTGACGAAGCGCGTG

CGCTGCTGCCGAACGTTATCACCAAAGAAGTTTCTCACGAAATCATCAAAGACCG

TCGTTTCACCTCTGACAAATTCTTCTTCCACGTTCCGATCACCCTGAACTACCAG

GCGGCGAACTCTCCGTCTAAATTCAACCAGCGTGTTAACGCGTACCTGAAAGAAC

ACCCGGAAACCCCGATCATCGGTATCGACCGTGGTGAACGTAACCTGATCTACAT

CACCGTTATCGACTCTACCGGTAAAATCCTGGAACAGCGTTCTCTGAACACCATC

CAGCAGTTCGACTACCAGAAAAAACTGGACAACCGTGAAAAAGAACGTGTTGCGG

CGCGTCAGGCGTGGTCTGTTGTTGGTACCATCAAAGACCTGAAACAGGGTTACCT

GTCTCAGGTTATCCACGAAATCGTTGACCTGATGATCCACTACCAGGCGGTTGTT

GTTCTGGAAAACCTGAACTTCGGTTTCAAATCTAAACGTACCGGTATCGCGGAAA

AAGCGGTTTACCAGCAGTTCGAAAAAATGCTGATCGACAAACTGAACTGCCTGGT

TCTGAAAGACTACCCGGCGGAAAAAGTTGGTGGTGTTCTGAACCCGTACCAGCTG

ACCGACCAGTTCACCTCTTTCGCGAAAATGGGTACCCAGTCTGGTTTCCTGTTCT

ACGTTCCGGCGCCGTACACCTCTAAAATCGACCCGCTGACCGGTTTCGTTGACCC

GTTCGTTTGGAAAACCATCAAAAACCACGAATCTCGTAAACACTTCCTGGAAGGT

TTCGACTTCCTGCACTACGACGTTAAAACCGGTGACTTCATCCTGCACTTCAAAA

TGAACCGTAACCTGTCTTTCCAGCGTGGTCTGCCGGGTTTCATGCCGGCGTGGGA

CATCGTTTTCGAAAAAAACGAAACCCAGTTCGACGCGAAAGGTACCCCGTTCATC

GCGGGTAAACGTATCGTTCCGGTTATCGAAAACCACCGTTTCACCGGTCGTTACC

GTGACCTGTACCCGGCGAACGAACTGATCGCGCTGCTGGAAGAAAAAGGTATCGT

TTTCCGTGACGGTTCTAACATCCTGCCGAAACTGCTGGAAAACGACGACTCTCAC

GCGATCGACACCATGGTTGCGCTGATCCGTTCTGTTCTGCAGATGCGTAACTCTA

ACGCGGCGACCGGTGAAGACTACATCAACTCTCCGGTTCGTGACCTGAACGGTGT

TTGCTTCGACTCTCGTTTCCAGAACCCGGAATGGCCGATGGACGCGGACGCGAAC

GGTGCGTACCACATCGCGCTGAAAGGTCAGCTGCTGCTGAACCACCTGAAAGAAT

CTAAAGACCTGAAACTGCAGAACGGTATCTCTAACCAGGACTGGCTGGCGTACAT

CCAGGAACTGCGTAACTA

SEQ
ATGGCGGTTAAATCTATCAAAGTTAAACTGCGTCTGGACGACATGCCGGAAATCC

ID
GTGCGGGTCTGTGGAAACTGCACAAAGAAGTTAACGCGGGTGTTCGTTACTACAC

NO:
CGAATGGCTGTCTCTGCTGCGTCAGGAAAACCTGTACCGTCGTTCTCCGAACGGT

53
GACGGTGAACAGGAATGCGACAAAACCGCGGAAGAATGCAAAGCGGAACTGCTGG

AACGTCTGCGTGCGCGTCAGGTTGAAAACGGTCACCGTGGTCCGGCGGGTTCTGA

CGACGAACTGCTGCAGCTGGCGCGTCAGCTGTACGAACTGCTGGTTCCGCAGGCG

ATCGGTGCGAAAGGTGACGCGCAGCAGATCGCGCGTAAATTCCTGTCTCCGCTGG

CGGACAAAGACGCGGTTGGTGGTCTGGGTATCGCGAAAGCGGGTAACAAACCGCG

TTGGGTTCGTATGCGTGAAGCGGGTGAACCGGGTTGGGAAGAAGAAAAAGAAAAA

GCGGAAACCCGTAAATCTGCGGACCGTACCGCGGACGTTCTGCGTGCGCTGGCGG

ACTTCGGTCTGAAACCGCTGATGCGTGTTTACACCGACTCTGAAATGTCTTCTGT

TGAATGGAAACCGCTGCGTAAAGGTCAGGCGGTTCGTACCTGGGACCGTGACATG

TTCCAGCAGGCGATCGAACGTATGATGTCTTGGGAATCTTGGAACCAGCGTGTTG

GTCAGGAATACGCGAAACTGGTTGAACAGAAAAACCGTTTCGAACAGAAAAACTT

CGTTGGTCAGGAACACCTGGTTCACCTGGTTAACCAGCTGCAGCAGGACATGAAA

GAAGCGTCTCCGGGTCTGGAATCTAAAGAACAGACCGCGCACTACGTTACCGGTC

GTGCGCTGCGTGGTTCTGACAAAGTTTTCGAAAAATGGGGTAAACTGGCGCCGGA

CGCGCCGTTCGACCTGTACGACGCGGAAATCAAAAACGTTCAGCGTCGTAACACC

CGTCGTTTCGGTTCTCACGACCTGTTCGCGAAACTGGCGGAACCGGAATACCAGG

CGCTGTGGCGTGAAGACGCGTCTTTCCTGACCCGTTACGCGGTTTACAACTCTAT

CCTGCGTAAACTGAACCACGCGAAAATGTTCGCGACCTTCACCCTGCCGGACGCG

ACCGCGCACCCGATCTGGACCCGTTTCGACAAACTGGGTGGTAACCTGCACCAGT

ACACCTTCCTGTTCAACGAATTCGGTGAACGTCGTCACGCGATCCGTTTCCACAA

ACTGCTGAAAGTTGAAAACGGTGTTGCGCGTGAAGTTGACGACGTTACCGTTCCG

ATCTCTATGTCTGAACAGCTGGACAACCTGCTGCCGCGTGACCCGAACGAACCGA

TCGCGCTGTACTTCCGTGACTACGGTGCGGAACAGCACTTCACCGGTGAATTCGG

TGGTGCGAAAATCCAGTGCCGTCGTGACCAGCTGGCGCACATGCACCGTCGTCGT

GGTGCGCGTGACGTTTACCTGAACGTTTCTGTTCGTGTTCAGTCTCAGTCTGAAG

CGCGTGGTGAACGTCGTCCGCCGTACGCGGCGGTTTTCCGTCTGGTTGGTGACAA

CCACCGTGCGTTCGTTCACTTCGACAAACTGTCTGACTACCTGGCGGAACACCCG

GACGACGGTAAACTGGGTTCTGAAGGTCTGCTGTCTGGTCTGCGTGTTATGTCTG

TTGACCTGGGTCTGCGTACCTCTGCGTCTATCTCTGTTTTCCGTGTTGCGCGTAA

AGACGAACTGAAACCGAACTCTAAAGGTCGTGTTCCGTTCTTCTTCCCGATCAAA

GGTAACGACAACCTGGTTGCGGTTCACGAACGTTCTCAGCTGCTGAAACTGCCGG

GTGAAACCGAATCTAAAGACCTGCGTGCGATCCGTGAAGAACGTCAGCGTACCCT

GCGTCAGCTGCGTACCCAGCTGGCGTACCTGCGTCTGCTGGTTCGTTGCGGTTCT

GAAGACGTTGGTCGTCGTGAACGTTCTTGGGCGAAACTGATCGAACAGCCGGTTG

ACGCGGCGAACCACATGACCCCGGACTGGCGTGAAGCGTTCGAAAACGAACTGCA

GAAACTGAAATCTCTGCACGGTATCTGCTCTGACAAAGAATGGATGGACGCGGTT

TACGAATCTGTTCGTCGTGTTTGGCGTCACATGGGTAAACAGGTTCGTGACTGGC

GTAAAGACGTTCGTTCTGGTGAACGTCCGAAAATCCGTGGTTACGCGAAAGACGT

TGTTGGTGGTAACTCTATCGAACAGATCGAATACCTGGAACGTCAGTACAAATTC

CTGAAATCTTGGTCTTTCTTCGGTAAAGTTTCTGGTCAGGTTATCCGTGCGGAAA

AAGGTTCTCGTTTCGCGATCACCCTGCGTGAACACATCGACCACGCGAAAGAAGA

CCGTCTGAAAAAACTGGCGGACCGTATCATCATGGAAGCGCTGGGTTACGTTTAC

GCGCTGGACGAACGTGGTAAAGGTAAATGGGTTGCGAAATACCCGCCGTGCCAGC

TGATCCTGCTGGAAGAACTGTCTGAATACCAGTTCAACAACGACCGTCCGCCGTC

TGAAAACAACCAGCTGATGCAGTGGTCTCACCGTGGTGTTTTCCAGGAACTGATC

AACCAGGCGCAGGTTCACGACCTGCTGGTTGGTACCATGTACGCGGCGTTCTCTT

CTCGTTTCGACGCGCGTACCGGTGCGCCGGGTATCCGTTGCCGTCGTGTTCCGGC

GCGTTGCACCCAGGAACACAACCCGGAACCGTTCCCGTGGTGGCTGAACAAATTC

GTTGTTGAACACACCCTGGACGCGTGCCCGCTGCGTGCGGACGACCTGATCCCGA

CCGGTGAAGGTGAAATCTTCGTTTCTCCGTTCTCTGCGGAAGAAGGTGACTTCCA

CCAGATCCACGCGGACCTGAACGCGGCGCAGAACCTGCAGCAGCGTCTGTGGTCT

GACTTCGACATCTCTCAGATCCGTCTGCGTTGCGACTGGGGTGAAGTTGACGGTG

AACTGGTTCTGATCCCGCGTCTGACCGGTAAACGTACCGCGGACTCTTACTCTAA

CAAAGTTTTCTACACCAACACCGGTGTTACCTACTACGAACGTGAACGTGGTAAA

AAACGTCGTAAAGTTTTCGCGCAGGAAAAACTGTCTGAAGAAGAAGCGGAACTGC

TGGTTGAAGCGGACGAAGCGCGTGAAAAATCTGTTGTTCTGATGCGTGACCCGTC

TGGTATCATCAACCGTGGTAACTGGACCCGTCAGAAAGAATTCTGGTCTATGGTT

AACCAGCGTATCGAAGGTTACCTGGTTAAACAGATCCGTTCTCGTGTTCCGCTGC

AGGACTCTGCGTGCGAAAACACCGGTGACATCTAA

SEQ
ATGGCGACCCGTTCTTTCATCCTGAAAATCGAACCGAACGAAGAAGTTAAAAAAG

ID
GTCTGTGGAAAACCCACGAAGTTCTGAACCACGGTATCGCGTACTACATGAACAT

NO:
CCTGAAACTGATCCGTCAGGAAGCGATCTACGAACACCACGAACAGGACCCGAAA

54
AACCCGAAAAAAGTTTCTAAAGCGGAAATCCAGGCGGAACTGTGGGACTTCGTTC

TGAAAATGCAGAAATGCAACTCTTTCACCCACGAAGTTGACAAAGACGTTGTTTT

CAACATCCTGCGTGAACTGTACGAAGAACTGGTTCCGTCTTCTGTTGAAAAAAAA

GGTGAAGCGAACCAGCTGTCTAACAAATTCCTGTACCCGCTGGTTGACCCGAACT

CTCAGTCTGGTAAAGGTACCGCGTCTTCTGGTCGTAAACCGCGTTGGTACAACCT

GAAAATCGCGGGTGACCCGTCTTGGGAAGAAGAAAAAAAAAAATGGGAAGAAGAC

AAAAAAAAAGACCCGCTGGCGAAAATCCTGGGTAAACTGGCGGAATACGGTCTGA

TCCCGCTGTTCATCCCGTTCACCGACTCTAACGAACCGATCGTTAAAGAAATCAA

ATGGATGGAAAAATCTCGTAACCAGTCTGTTCGTCGTCTGGACAAAGACATGTTC

ATCCAGGCGCTGGAACGTTTCCTGTCTTGGGAATCTTGGAACCTGAAAGTTAAAG

AAGAATACGAAAAAGTTGAAAAAGAACACAAAACCCTGGAAGAACGTATCAAAGA

AGACATCCAGGCGTTCAAATCTCTGGAACAGTACGAAAAAGAACGTCAGGAACAG

CTGCTGCGTGACACCCTGAACACCAACGAATACCGTCTGTCTAAACGTGGTCTGC

GTGGTTGGCGTGAAATCATCCAGAAATGGCTGAAAATGGACGAAAACGAACCGTC

TGAAAAATACCTGGAAGTTTTCAAAGACTACCAGCGTAAACACCCGCGTGAAGCG

GGTGACTACTCTGTTTACGAATTCCTGTCTAAAAAAGAAAACCACTTCATCTGGC

GTAACCACCCGGAATACCCGTACCTGTACGCGACCTTCTGCGAAATCGACAAAAA

AAAAAAAGACGCGAAACAGCAGGCGACCTTCACCCTGGCGGACCCGATCAACCAC

CCGCTGTGGGTTCGTTTCGAAGAACGTTCTGGTTCTAACCTGAACAAATACCGTA

TCCTGACCGAACAGCTGCACACCGAAAAACTGAAAAAAAAACTGACCGTTCAGCT

GGACCGTCTGATCTACCCGACCGAATCTGGTGGTTGGGAAGAAAAAGGTAAAGTT

GACATCGTTCTGCTGCCGTCTCGTCAGTTCTACAACCAGATCTTCCTGGACATCG

AAGAAAAAGGTAAACACGCGTTCACCTACAAAGACGAATCTATCAAATTCCCGCT

GAAAGGTACCCTGGGTGGTGCGCGTGTTCAGTTCGACCGTGACCACCTGCGTCGT

TACCCGCACAAAGTTGAATCTGGTAACGTTGGTCGTATCTACTTCAACATGACCG

TTAACATCGAACCGACCGAATCTCCGGTTTCTAAATCTCTGAAAATCCACCGTGA

CGACTTCCCGAAATTCGTTAACTTCAAACCGAAAGAACTGACCGAATGGATCAAA

GACTCTAAAGGTAAAAAACTGAAATCTGGTATCGAATCTCTGGAAATCGGTCTGC

GTGTTATGTCTATCGACCTGGGTCAGCGTCAGGCGGCGGCGGCGTCTATCTTCGA

AGTTGTTGACCAGAAACCGGACATCGAAGGTAAACTGTTCTTCCCGATCAAAGGT

ACCGAACTGTACGCGGTTCACCGTGCGTCTTTCAACATCAAACTGCCGGGTGAAA

CCCTGGTTAAATCTCGTGAAGTTCTGCGTAAAGCGCGTGAAGACAACCTGAAACT

GATGAACCAGAAACTGAACTTCCTGCGTAACGTTCTGCACTTCCAGCAGTTCGAA

GACATCACCGAACGTGAAAAACGTGTTACCAAATGGATCTCTCGTCAGGAAAACT

CTGACGTTCCGCTGGTTTACCAGGACGAACTGATCCAGATCCGTGAACTGATGTA

CAAACCGTACAAAGACTGGGTTGCGTTCCTGAAACAGCTGCACAAACGTCTGGAA

GTTGAAATCGGTAAAGAAGTTAAACACTGGCGTAAATCTCTGTCTGACGGTCGTA

AAGGTCTGTACGGTATCTCTCTGAAAAACATCGACGAAATCGACCGTACCCGTAA

ATTCCTGCTGCGTTGGTCTCTGCGTCCGACCGAACCGGGTGAAGTTCGTCGTCTG

GAACCGGGTCAGCGTTTCGCGATCGACCAGCTGAACCACCTGAACGCGCTGAAAG

AAGACCGTCTGAAAAAAATGGCGAACACCATCATCATGCACGCGCTGGGTTACTG

CTACGACGTTCGTAAAAAAAAATGGCAGGCGAAAAACCCGGCGTGCCAGATCATC

CTGTTCGAAGACCTGTCTAACTACAACCCGTACGAAGAACGTTCTCGTTTCGAAA

ACTCTAAACTGATGAAATGGTCTCGTCGTGAAATCCCGCGTCAGGTTGCGCTGCA

GGGTGAAATCTACGGTCTGCAGGTTGGTGAAGTTGGTGCGCAGTTCTCTTCTCGT

TTCCACGCGAAAACCGGTTCTCCGGGTATCCGTTGCTCTGTTGTTACCAAAGAAA

AACTGCAGGACAACCGTTTCTTCAAAAACCTGCAGCGTGAAGGTCGTCTGACCCT

GGACAAAATCGCGGTTCTGAAAGAAGGTGACCTGTACCCGGACAAAGGTGGTGAA

AAATTCATCTCTCTGTCTAAAGACCGTAAACTGGTTACCACCCACGCGGACATCA

ACGCGGCGCAGAACCTGCAGAAACGTTTCTGGACCCGTACCCACGGTTTCTACAA

AGTTTACTGCAAAGCGTACCAGGTTGACGGTCAGACCGTTTACATCCCGGAATCT

AAAGACCAGAAACAGAAAATCATCGAAGAATTCGGTGAAGGTTACTTCATCCTGA

AAGACGGTGTTTACGAATGGGGTAACGCGGGTAAACTGAAAATCAAAAAAGGTTC

TTCTAAACAGTCTTCTTCTGAACTGGTTGACTCTGACATCCTGAAAGACTCTTTC

GACCTGGCGTCTGAACTGAAAGGTGAAAAACTGATGCTGTACCGTGACCCGTCTG

GTAACGTTTTCCCGTCTGACAAATGGATGGCGGCGGGTGTTTTCTTCGGTAAACT

GGAACGTATCCTGATCTCTAAACTGACCAACCAGTACTCTATCTCTACCATCGAA

GACGACTCTTCTAAACAGTCTATGTAA

SEQ
ATGCCGACCCGTACCATCAACCTGAAACTGGTTCTGGGTAAAAACCCGGAAAACG

ID
CGACCCTGCGTCGTGCGCTGTTCTCTACCCACCGTCTGGTTAACCAGGCGACCAA

NO:
ACGTATCGAAGAATTCCTGCTGCTGTGCCGTGGTGAAGCGTACCGTACCGTTGAC

55
AACGAAGGTAAAGAAGCGGAAATCCCGCGTCACGCGGTTCAGGAAGAAGCGCTGG

CGTTCGCGAAAGCGGCGCAGCGTCACAACGGTTGCATCTCTACCTACGAAGACCA

GGAAATCCTGGACGTTCTGCGTCAGCTGTACGAACGTCTGGTTCCGTCTGTTAAC

GAAAACAACGAAGCGGGTGACGCGCAGGCGGCGAACGCGTGGGTTTCTCCGCTGA

TGTCTGCGGAATCTGAAGGTGGTCTGTCTGTTTACGACAAAGTTCTGGACCCGCC

GCCGGTTTGGATGAAACTGAAAGAAGAAAAAGCGCCGGGTTGGGAAGCGGCGTCT

CAGATCTGGATCCAGTCTGACGAAGGTCAGTCTCTGCTGAACAAACCGGGTTCTC

CGCCGCGTTGGATCCGTAAACTGCGTTCTGGTCAGCCGTGGCAGGACGACTTCGT

TTCTGACCAGAAAAAAAAACAGGACGAACTGACCAAAGGTAACGCGCCGCTGATC

AAACAGCTGAAAGAAATGGGTCTGCTGCCGCTGGTTAACCCGTTCTTCCGTCACC

TGCTGGACCCGGAAGGTAAAGGTGTTTCTCCGTGGGACCGTCTGGCGGTTCGTGC

GGCGGTTGCGCACTTCATCTCTTGGGAATCTTGGAACCACCGTACCCGTGCGGAA

TACAACTCTCTGAAACTGCGTCGTGACGAATTCGAAGCGGCGTCTGACGAATTCA

AAGACGACTTCACCCTGCTGCGTCAGTACGAAGCGAAACGTCACTCTACCCTGAA

ATCTATCGCGCTGGCGGACGACTCTAACCCGTACCGTATCGGTGTTCGTTCTCTG

CGTGCGTGGAACCGTGTTCGTGAAGAATGGATCGACAAAGGTGCGACCGAAGAAC

AGCGTGTTACCATCCTGTCTAAACTGCAGACCCAGCTGCGTGGTAAATTCGGTGA

CCCGGACCTGTTCAACTGGCTGGCGCAGGACCGTCACGTTCACCTGTGGTCTCCG

CGTGACTCTGTTACCCCGCTGGTTCGTATCAACGCGGTTGACAAAGTTCTGCGTC

GTCGTAAACCGTACGCGCTGATGACCTTCGCGCACCCGCGTTTCCACCCGCGTTG

GATCCTGTACGAAGCGCCGGGTGGTTCTAACCTGCGTCAGTACGCGCTGGACTGC

ACCGAAAACGCGCTGCACATCACCCTGCCGCTGCTGGTTGACGACGCGCACGGTA

CCTGGATCGAAAAAAAAATCCGTGTTCCGCTGGCGCCGTCTGGTCAGATCCAGGA

CCTGACCCTGGAAAAACTGGAAAAAAAAAAAAACCGTCTGTACTACCGTTCTGGT

TTCCAGCAGTTCGCGGGTCTGGCGGGTGGTGCGGAAGTTCTGTTCCACCGTCCGT

ACATGGAACACGACGAACGTTCTGAAGAATCTCTGCTGGAACGTCCGGGTGCGGT

TTGGTTCAAACTGACCCTGGACGTTGCGACCCAGGCGCCGCCGAACTGGCTGGAC

GGTAAAGGTCGTGTTCGTACCCCGCCGGAAGTTCACCACTTCAAAACCGCGCTGT

CTAACAAATCTAAACACACCCGTACCCTGCAGCCGGGTCTGCGTGTTCTGTCTGT

TGACCTGGGTATGCGTACCTTCGCGTCTTGCTCTGTTTTCGAACTGATCGAAGGT

AAACCGGAAACCGGTCGTGCGTTCCCGGTTGCGGACGAACGTTCTATGGACTCTC

CGAACAAACTGTGGGCGAAACACGAACGTTCTTTCAAACTGACCCTGCCGGGTGA

AACCCCGTCTCGTAAAGAAGAAGAAGAACGTTCTATCGCGCGTGCGGAAATCTAC

GCGCTGAAACGTGACATCCAGCGTCTGAAATCTCTGCTGCGTCTGGGTGAAGAAG

ACAACGACAACCGTCGTGACGCGCTGCTGGAACAGTTCTTCAAAGGTTGGGGTGA

AGAAGACGTTGTTCCGGGTCAGGCGTTCCCGCGTTCTCTGTTCCAGGGTCTGGGT

GCGGCGCCGTTCCGTTCTACCCCGGAACTGTGGCGTCAGCACTGCCAGACCTACT

ACGACAAAGCGGAAGCGTGCCTGGCGAAACACATCTCTGACTGGCGTAAACGTAC

CCGTCCGCGTCCGACCTCTCGTGAAATGTGGTACAAAACCCGTTCTTACCACGGT

GGTAAATCTATCTGGATGCTGGAATACCTGGACGCGGTTCGTAAACTGCTGCTGT

CTTGGTCTCTGCGTGGTCGTACCTACGGTGCGATCAACCGTCAGGACACCGCGCG

TTTCGGTTCTCTGGCGTCTCGTCTGCTGCACCACATCAACTCTCTGAAAGAAGAC

CGTATCAAAACCGGTGCGGACTCTATCGTTCAGGCGGCGCGTGGTTACATCCCGC

TGCCGCACGGTAAAGGTTGGGAACAGCGTTACGAACCGTGCCAGCTGATCCTGTT

CGAAGACCTGGCGCGTTACCGTTTCCGTGTTGACCGTCCGCGTCGTGAAAACTCT

CAGCTGATGCAGTGGAACCACCGTGCGATCGTTGCGGAAACCACCATGCAGGCGG

AACTGTACGGTCAGATCGTTGAAAACACCGCGGCGGGTTTCTCTTCTCGTTTCCA

CGCGGCGACCGGTGCGCCGGGTGTTCGTTGCCGTTTCCTGCTGGAACGTGACTTC

GACAACGACCTGCCGAAACCGTACCTGCTGCGTGAACTGTCTTGGATGCTGGGTA

ACACCAAAGTTGAATCTGAAGAAGAAAAACTGCGTCTGCTGTCTGAAAAAATCCG

TCCGGGTTCTCTGGTTCCGTGGGACGGTGGTGAACAGTTCGCGACCCTGCACCCG

AAACGTCAGACCCTGTGCGTTATCCACGCGGACATGAACGCGGCGCAGAACCTGC

AGCGTCGTTTCTTCGGTCGTTGCGGTGAAGCGTTCCGTCTGGTTTGCCAGCCGCA

CGGTGACGACGTTCTGCGTCTGGCGTCTACCCCGGGTGCGCGTCTGCTGGGTGCG

CTGCAGCAGCTGGAAAACGGTCAGGGTGCGTTCGAACTGGTTCGTGACATGGGTT

CTACCTCTCAGATGAACCGTTTCGTTATGAAATCTCTGGGTAAAAAAAAAATCAA

ACCGCTGCAGGACAACAACGGTGACGACGAACTGGAAGACGTTCTGTCTGTTCTG

CCGGAAGAAGACGACACCGGTCGTATCACCGTTTTCCGTGACTCTTCTGGTATCT

TCTTCCCGTGCAACGTTTGGATCCCGGCGAAACAGTTCTGGCCGGCGGTTCGTGC

GATGATCTGGAAAGTTATGGCGTCTCACTCTCTGGGTTAA

SEQ
ATGACCAAACTGCGTCACCGTCAGAAAAAACTGACCCACGACTGGGCGGGTTCTA

ID
AAAAACGTGAAGTTCTGGGTTCTAACGGTAAACTGCAGAACCCGCTGCTGATGCC

NO:
GGTTAAAAAAGGTCAGGTTACCGAATTCCGTAAAGCGTTCTCTGCGTACGCGCGT

56
GCGACCAAAGGTGAAATGACCGACGGTCGTAAAAACATGTTCACCCACTCTTTCG

AACCGTTCAAAACCAAACCGTCTCTGCACCAGTGCGAACTGGCGGACAAAGCGTA

CCAGTCTCTGCACTCTTACCTGCCGGGTTCTCTGGCGCACTTCCTGCTGTCTGCG

CACGCGCTGGGTTTCCGTATCTTCTCTAAATCTGGTGAAGCGACCGCGTTCCAGG

CGTCTTCTAAAATCGAAGCGTACGAATCTAAACTGGCGTCTGAACTGGCGTGCGT

TGACCTGTCTATCCAGAACCTGACCATCTCTACCCTGTTCAACGCGCTGACCACC

TCTGTTCGTGGTAAAGGTGAAGAAACCTCTGCGGACCCGCTGATCGCGCGTTTCT

ACACCCTGCTGACCGGTAAACCGCTGTCTCGTGACACCCAGGGTCCGGAACGTGA

CCTGGCGGAAGTTATCTCTCGTAAAATCGCGTCTTCTTTCGGTACCTGGAAAGAA

ATGACCGCGAACCCGCTGCAGTCTCTGCAGTTCTTCGAAGAAGAACTGCACGCGC

TGGACGCGAACGTTTCTCTGTCTCCGGCGTTCGACGTTCTGATCAAAATGAACGA

CCTGCAGGGTGACCTGAAAAACCGTACCATCGTTTTCGACCCGGACGCGCCGGTT

TTCGAATACAACGCGGAAGACCCGGCGGACATCATCATCAAACTGACCGCGCGTT

ACGCGAAAGAAGCGGTTATCAAAAACCAGAACGTTGGTAACTACGTTAAAAACGC

GATCACCACCACCAACGCGAACGGTCTGGGTTGGCTGCTGAACAAAGGTCTGTCT

CTGCTGCCGGTTTCTACCGACGACGAACTGCTGGAATTCATCGGTGTTGAACGTT

CTCACCCGTCTTGCCACGCGCTGATCGAACTGATCGCGCAGCTGGAAGCGCCGGA

ACTGTTCGAAAAAAACGTTTTCTCTGACACCCGTTCTGAAGTTCAGGGTATGATC

GACTCTGCGGTTTCTAACCACATCGCGCGTCTGTCTTCTTCTCGTAACTCTCTGT

CTATGGACTCTGAAGAACTGGAACGTCTGATCAAATCTTTCCAGATCCACACCCC

GCACTGCTCTCTGTTCATCGGTGCGCAGTCTCTGTCTCAGCAGCTGGAATCTCTG

CCGGAAGCGCTGCAGTCTGGTGTTAACTCTGCGGACATCCTGCTGGGTTCTACCC

AGTACATGCTGACCAACTCTCTGGTTGAAGAATCTATCGCGACCTACCAGCGTAC

CCTGAACCGTATCAACTACCTGTCTGGTGTTGCGGGTCAGATCAACGGTGCGATC

AAACGTAAAGCGATCGACGGTGAAAAAATCCACCTGCCGGCGGCGTGGTCTGAAC

TGATCTCTCTGCCGTTCATCGGTCAGCCGGTTATCGACGTTGAATCTGACCTGGC

GCACCTGAAAAACCAGTACCAGACCCTGTCTAACGAATTCGACACCCTGATCTCT

GCGCTGCAGAAAAACTTCGACCTGAACTTCAACAAAGCGCTGCTGAACCGTACCC

AGCACTTCGAAGCGATGTGCCGTTCTACCAAAAAAAACGCGCTGTCTAAACCGGA

AATCGTTTCTTACCGTGACCTGCTGGCGCGTCTGACCTCTTGCCTGTACCGTGGT

TCTCTGGTTCTGCGTCGTGCGGGTATCGAAGTTCTGAAAAAACACAAAATCTTCG

AATCTAACTCTGAACTGCGTGAACACGTTCACGAACGTAAACACTTCGTTTTCGT

TTCTCCGCTGGACCGTAAAGCGAAAAAACTGCTGCGTCTGACCGACTCTCGTCCG

GACCTGCTGCACGTTATCGACGAAATCCTGCAGCACGACAACCTGGAAAACAAAG

ACCGTGAATCTCTGTGGCTGGTTCGTTCTGGTTACCTGCTGGCGGGTCTGCCGGA

CCAGCTGTCTTCTTCTTTCATCAACCTGCCGATCATCACCCAGAAAGGTGACCGT

CGTCTGATCGACCTGATCCAGTACGACCAGATCAACCGTGACGCGTTCGTTATGC

TGGTTACCTCTGCGTTCAAATCTAACCTGTCTGGTCTGCAGTACCGTGCGAACAA

ACAGTCTTTCGTTGTTACCCGTACCCTGTCTCCGTACCTGGGTTCTAAACTGGTT

TACGTTCCGAAAGACAAAGACTGGCTGGTTCCGTCTCAGATGTTCGAAGGTCGTT

TCGCGGACATCCTGCAGTCTGACTACATGGTTTGGAAAGACGCGGGTCGTCTGTG

CGTTATCGACACCGCGAAACACCTGTCTAACATCAAAAAATCTGTTTTCTCTTCT

GAAGAAGTTCTGGCGTTCCTGCGTGAACTGCCGCACCGTACCTTCATCCAGACCG

AAGTTCGTGGTCTGGGTGTTAACGTTGACGGTATCGCGTTCAACAACGGTGACAT

CCCGTCTCTGAAAACCTTCTCTAACTGCGTTCAGGTTAAAGTTTCTCGTACCAAC

ACCTCTCTGGTTCAGACCCTGAACCGTTGGTTCGAAGGTGGTAAAGTTTCTCCGC

CGTCTATCCAGTTCGAACGTGCGTACTACAAAAAAGACGACCAGATCCACGAAGA

CGCGGCGAAACGTAAAATCCGTTTCCAGATGCCGGCGACCGAACTGGTTCACGCG

TCTGACGACGCGGGTTGGACCCCGTCTTACCTGCTGGGTATCGACCCGGGTGAAT

ACGGTATGGGTCTGTCTCTGGTTTCTATCAACAACGGTGAAGTTCTGGACTCTGG

TTTCATCCACATCAACTCTCTGATCAACTTCGCGTCTAAAAAATCTAACCACCAG

ACCAAAGTTGTTCCGCGTCAGCAGTACAAATCTCCGTACGCGAACTACCTGGAAC

AGTCTAAAGACTCTGCGGCGGGTGACATCGCGCACATCCTGGACCGTCTGATCTA

CAAACTGAACGCGCTGCCGGTTTTCGAAGCGCTGTCTGGTAACTCTCAGTCTGCG

GCGGACCAGGTTTGGACCAAAGTTCTGTCTTTCTACACCTGGGGTGACAACGACG

CGCAGAACTCTATCCGTAAACAGCACTGGTTCGGTGCGTCTCACTGGGACATCAA

AGGTATGCTGCGTCAGCCGCCGACCGAAAAAAAACCGAAACCGTACATCGCGTTC

CCGGGTTCTCAGGTTTCTTCTTACGGTAACTCTCAGCGTTGCTCTTGCTGCGGTC

GTAACCCGATCGAACAGCTGCGTGAAATGGCGAAAGACACCTCTATCAAAGAACT

GAAAATCCGTAACTCTGAAATCCAGCTGTTCGACGGTACCATCAAACTGTTCAAC

CCGGACCCGTCTACCGTTATCGAACGTCGTCGTCACAACCTGGGTCCGTCTCGTA

TCCCGGTTGCGGACCGTACCTTCAAAAACATCTCTCCGTCTTCTCTGGAATTCAA

AGAACTGATCACCATCGTTTCTCGTTCTATCCGTCACTCTCCGGAATTCATCGCG

AAAAAACGTGGTATCGGTTCTGAATACTTCTGCGCGTACTCTGACTGCAACTCTT

CTCTGAACTCTGAAGCGAACGCGGCGGCGAACGTTGCGCAGAAATTCCAGAAACA

GCTGTTCTTCGAACTGTAA

SEQ
ATGAAACGTATCCTGAACTCTCTGAAAGTTGCGGCGCTGCGTCTGCTGTTCCGTG

ID
GTAAAGGTTCTGAACTGGTTAAAACCGTTAAATACCCGCTGGTTTCTCCGGTTCA

NO:
GGGTGCGGTTGAAGAACTGGCGGAAGCGATCCGTCACGACAACCTGCACCTGTTC

57
GGTCAGAAAGAAATCGTTGACCTGATGGAAAAAGACGAAGGTACCCAGGTTTACT

CTGTTGTTGACTTCTGGCTGGACACCCTGCGTCTGGGTATGTTCTTCTCTCCGTC

TGCGAACGCGCTGAAAATCACCCTGGGTAAATTCAACTCTGACCAGGTTTCTCCG

TTCCGTAAAGTTCTGGAACAGTCTCCGTTCTTCCTGGCGGGTCGTCTGAAAGTTG

AACCGGCGGAACGTATCCTGTCTGTTGAAATCCGTAAAATCGGTAAACGTGAAAA

CCGTGTTGAAAACTACGCGGCGGACGTTGAAACCTGCTTCATCGGTCAGCTGTCT

TCTGACGAAAAACAGTCTATCCAGAAACTGGCGAACGACATCTGGGACTCTAAAG

ACCACGAAGAACAGCGTATGCTGAAAGCGGACTTCTTCGCGATCCCGCTGATCAA

AGACCCGAAAGCGGTTACCGAAGAAGACCCGGAAAACGAAACCGCGGGTAAACAG

AAACCGCTGGAACTGTGCGTTTGCCTGGTTCCGGAACTGTACACCCGTGGTTTCG

GTTCTATCGCGGACTTCCTGGTTCAGCGTCTGACCCTGCTGCGTGACAAAATGTC

TACCGACACCGCGGAAGACTGCCTGGAATACGTTGGTATCGAAGAAGAAAAAGGT

AACGGTATGAACTCTCTGCTGGGTACCTTCCTGAAAAACCTGCAGGGTGACGGTT

TCGAACAGATCTTCCAGTTCATGCTGGGTTCTTACGTTGGTTGGCAGGGTAAAGA

AGACGTTCTGCGTGAACGTCTGGACCTGCTGGCGGAAAAAGTTAAACGTCTGCCG

AAACCGAAATTCGCGGGTGAATGGTCTGGTCACCGTATGTTCCTGCACGGTCAGC

TGAAATCTTGGTCTTCTAACTTCTTCCGTCTGTTCAACGAAACCCGTGAACTGCT

GGAATCTATCAAATCTGACATCCAGCACGCGACCATGCTGATCTCTTACGTTGAA

GAAAAAGGTGGTTACCACCCGCAGCTGCTGTCTCAGTACCGTAAACTGATGGAAC

AGCTGCCGGCGCTGCGTACCAAAGTTCTGGACCCGGAAATCGAAATGACCCACAT

GTCTGAAGCGGTTCGTTCTTACATCATGATCCACAAATCTGTTGCGGGTTTCCTG

CCGGACCTGCTGGAATCTCTGGACCGTGACAAAGACCGTGAATTCCTGCTGTCTA

TCTTCCCGCGTATCCCGAAAATCGACAAAAAAACCAAAGAAATCGTTGCGTGGGA

ACTGCCGGGTGAACCGGAAGAAGGTTACCTGTTCACCGCGAACAACCTGTTCCGT

AACTTCCTGGAAAACCCGAAACACGTTCCGCGTTTCATGGCGGAACGTATCCCGG

AAGACTGGACCCGTCTGCGTTCTGCGCCGGTTTGGTTCGACGGTATGGTTAAACA

GTGGCAGAAAGTTGTTAACCAGCTGGTTGAATCTCCGGGTGCGCTGTACCAGTTC

AACGAATCTTTCCTGCGTCAGCGTCTGCAGGCGATGCTGACCGTTTACAAACGTG

ACCTGCAGACCGAAAAATTCCTGAAACTGCTGGCGGACGTTTGCCGTCCGCTGGT

TGACTTCTTCGGTCTGGGTGGTAACGACATCATCTTCAAATCTTGCCAGGACCCG

CGTAAACAGTGGCAGACCGTTATCCCGCTGTCTGTTCCGGCGGACGTTTACACCG

CGTGCGAAGGTCTGGCGATCCGTCTGCGTGAAACCCTGGGTTTCGAATGGAAAAA

CCTGAAAGGTCACGAACGTGAAGACTTCCTGCGTCTGCACCAGCTGCTGGGTAAC

CTGCTGTTCTGGATCCGTGACGCGAAACTGGTTGTTAAACTGGAAGACTGGATGA

ACAACCCGTGCGTTCAGGAATACGTTGAAGCGCGTAAAGCGATCGACCTGCCGCT

GGAAATCTTCGGTTTCGAAGTTCCGATCTTCCTGAACGGTTACCTGTTCTCTGAA

CTGCGTCAGCTGGAACTGCTGCTGCGTCGTAAATCTGTTATGACCTCTTACTCTG

TTAAAACCACCGGTTCTCCGAACCGTCTGTTCCAGCTGGTTTACCTGCCGCTGAA

CCCGTCTGACCCGGAAAAAAAAAACTCTAACAACTTCCAGGAACGTCTGGACACC

CCGACCGGTCTGTCTCGTCGTTTCCTGGACCTGACCCTGGACGCGTTCGCGGGTA

AACTGCTGACCGACCCGGTTACCCAGGAACTGAAAACCATGGCGGGTTTCTACGA

CCACCTGTTCGGTTTCAAACTGCCGTGCAAACTGGCGGCGATGTCTAACCACCCG

GGTTCTTCTTCTAAAATGGTTGTTCTGGCGAAACCGAAAAAAGGTGTTGCGTCTA

ACATCGGTTTCGAACCGATCCCGGACCCGGCGCACCCGGTTTTCCGTGTTCGTTC

TTCTTGGCCGGAACTGAAATACCTGGAAGGTCTGCTGTACCTGCCGGAAGACACC

CCGCTGACCATCGAACTGGCGGAAACCTCTGTTTCTTGCCAGTCTGTTTCTTCTG

TTGCGTTCGACCTGAAAAACCTGACCACCATCCTGGGTCGTGTTGGTGAATTCCG

TGTTACCGCGGACCAGCCGTTCAAACTGACCCCGATCATCCCGGAAAAAGAAGAA

TCTTTCATCGGTAAAACCTACCTGGGTCTGGACGCGGGTGAACGTTCTGGTGTTG

GTTTCGCGATCGTTACCGTTGACGGTGACGGTTACGAAGTTCAGCGTCTGGGTGT

TCACGAAGACACCCAGCTGATGGCGCTGCAGCAGGTTGCGTCTAAATCTCTGAAA

GAACCGGTTTTCCAGCCGCTGCGTAAAGGTACCTTCCGTCAGCAGGAACGTATCC

GTAAATCTCTGCGTGGTTGCTACTGGAACTTCTACCACGCGCTGATGATCAAATA

CCGTGCGAAAGTTGTTCACGAAGAATCTGTTGGTTCTTCTGGTCTGGTTGGTCAG

TGGCTGCGTGCGTTCCAGAAAGACCTGAAAAAAGCGGACGTTCTGCCGAAAAAAG

GTGGTAAAAACGGTGTTGACAAAAAAAAACGTGAATCTTCTGCGCAGGACACCCT

GTGGGGTGGTGCGTTCTCTAAAAAAGAAGAACAGCAGATCGCGTTCGAAGTTCAG

GCGGCGGGTTCTTCTCAGTTCTGCCTGAAATGCGGTTGGTGGTTCCAGCTGGGTA

TGCGTGAAGTTAACCGTGTTCAGGAATCTGGTGTTGTTCTGGACTGGAACCGTTC

TATCGTTACCTTCCTGATCGAATCTTCTGGTGAAAAAGTTTACGGTTTCTCTCCG

CAGCAGCTGGAAAAAGGTTTCCGTCCGGACATCGAAACCTTCAAAAAAATGGTTC

GTGACTTCATGCGTCCGCCGATGTTCGACCGTAAAGGTCGTCCGGCGGCGGCGTA

CGAACGTTTCGTTCTGGGTCGTCGTCACCGTCGTTACCGTTTCGACAAAGTTTTC

GAAGAACGTTTCGGTCGTTCTGCGCTGTTCATCTGCCCGCGTGTTGGTTGCGGTA

ACTTCGACCACTCTTCTGAACAGTCTGCGGTTGTTCTGGCGCTGATCGGTTACAT

CGCGGACAAAGAAGGTATGTCTGGTAAAAAACTGGTTTACGTTCGTCTGGCGGAA

CTGATGGCGGAATGGAAACTGAAAAAACTGGAACGTTCTCGTGTTGAAGAACAGT

CTTCTGCGCAGTAA

SEQ
ATGGCGGAATCTAAACAGATGCAGTGCCGTAAATGCGGTGCGTCTATGAAATACG

ID
AAGTTATCGGTCTGGGTAAAAAATCTTGCCGTTACATGTGCCCGGACTGCGGTAA

NO:
CCACACCTCTGCGCGTAAAATCCAGAACAAAAAAAAACGTGACAAAAAATACGGT

58
TCTGCGTCTAAAGCGCAGTCTCAGCGTATCGCGGTTGCGGGTGCGCTGTACCCGG

ACAAAAAAGTTCAGACCATCAAAACCTACAAATACCCGGCGGACCTGAACGGTGA

AGTTCACGACTCTGGTGTTGCGGAAAAAATCGCGCAGGCGATCCAGGAAGACGAA

ATCGGTCTGCTGGGTCCGTCTTCTGAATACGCGTGCTGGATCGCGTCTCAGAAAC

AGTCTGAACCGTACTCTGTTGTTGACTTCTGGTTCGACGCGGTTTGCGCGGGTGG

TGTTTTCGCGTACTCTGGTGCGCGTCTGCTGTCTACCGTTCTGCAGCTGTCTGGT

GAAGAATCTGTTCTGCGTGCGGCGCTGGCGTCTTCTCCGTTCGTTGACGACATCA

ACCTGGCGCAGGCGGAAAAATTCCTGGCGGTTTCTCGTCGTACCGGTCAGGACAA

ACTGGGTAAACGTATCGGTGAATGCTTCGCGGAAGGTCGTCTGGAAGCGCTGGGT

ATCAAAGACCGTATGCGTGAATTCGTTCAGGCGATCGACGTTGCGCAGACCGCGG

GTCAGCGTTTCGCGGCGAAACTGAAAATCTTCGGTATCTCTCAGATGCCGGAAGC

GAAACAGTGGAACAACGACTCTGGTCTGACCGTTTGCATCCTGCCGGACTACTAC

GTTCCGGAAGAAAACCGTGCGGACCAGCTGGTTGTTCTGCTGCGTCGTCTGCGTG

AAATCGCGTACTGCATGGGTATCGAAGACGAAGCGGGTTTCGAACACCTGGGTAT

CGACCCGGGTGCGCTGTCTAACTTCTCTAACGGTAACCCGAAACGTGGTTTCCTG

GGTCGTCTGCTGAACAACGACATCATCGCGCTGGCGAACAACATGTCTGCGATGA

CCCCGTACTGGGAAGGTCGTAAAGGTGAACTGATCGAACGTCTGGCGTGGCTGAA

ACACCGTGCGGAAGGTCTGTACCTGAAAGAACCGCACTTCGGTAACTCTTGGGCG

GACCACCGTTCTCGTATCTTCTCTCGTATCGCGGGTTGGCTGTCTGGTTGCGCGG

GTAAACTGAAAATCGCGAAAGACCAGATCTCTGGTGTTCGTACCGACCTGTTCCT

GCTGAAACGTCTGCTGGACGCGGTTCCGCAGTCTGCGCCGTCTCCGGACTTCATC

GCGTCTATCTCTGCGCTGGACCGTTTCCTGGAAGCGGCGGAATCTTCTCAGGACC

CGGCGGAACAGGTTCGTGCGCTGTACGCGTTCCACCTGAACGCGCCGGCGGTTCG

TTCTATCGCGAACAAAGCGGTTCAGCGTTCTGACTCTCAGGAATGGCTGATCAAA

GAACTGGACGCGGTTGACCACCTGGAATTCAACAAAGCGTTCCCGTTCTTCTCTG

ACACCGGTAAAAAAAAAAAAAAAGGTGCGAACTCTAACGGTGCGCCGTCTGAAGA

AGAATACACCGAAACCGAATCTATCCAGCAGCCGGAAGACGCGGAACAGGAAGTT

AACGGTCAGGAAGGTAACGGTGCGTCTAAAAACCAGAAAAAATTCCAGCGTATCC

CGCGTTTCTTCGGTGAAGGTTCTCGTTCTGAATACCGTATCCTGACCGAAGCGCC

GCAGTACTTCGACATGTTCTGCAACAACATGCGTGCGATCTTCATGCAGCTGGAA

TCTCAGCCGCGTAAAGCGCCGCGTGACTTCAAATGCTTCCTGCAGAACCGTCTGC

AGAAACTGTACAAACAGACCTTCCTGAACGCGCGTTCTAACAAATGCCGTGCGCT

GCTGGAATCTGTTCTGATCTCTTGGGGTGAATTCTACACCTACGGTGCGAACGAA

AAAAAATTCCGTCTGCGTCACGAAGCGTCTGAACGTTCTTCTGACCCGGACTACG

TTGTTCAGCAGGCGCTGGAAATCGCGCGTCGTCTGTTCCTGTTCGGTTTCGAATG

GCGTGACTGCTCTGCGGGTGAACGTGTTGACCTGGTTGAAATCCACAAAAAAGCG

ATCTCTTTCCTGCTGGCGATCACCCAGGCGGAAGTTTCTGTTGGTTCTTACAACT

GGCTGGGTAACTCTACCGTTTCTCGTTACCTGTCTGTTGCGGGTACCGACACCCT

GTACGGTACCCAGCTGGAAGAATTCCTGAACGCGACCGTTCTGTCTCAGATGCGT

GGTCTGGCGATCCGTCTGTCTTCTCAGGAACTGAAAGACGGTTTCGACGTTCAGC

TGGAATCTTCTTGCCAGGACAACCTGCAGCACCTGCTGGTTTACCGTGCGTCTCG

TGACCTGGCGGCGTGCAAACGTGCGACCTGCCCGGCGGAACTGGACCCGAAAATC

CTGGTTCTGCCGGTTGGTGCGTTCATCGCGTCTGTTATGAAAATGATCGAACGTG

GTGACGAACCGCTGGCGGGTGCGTACCTGCGTCACCGTCCGCACTCTTTCGGTTG

GCAGATCCGTGTTCGTGGTGTTGCGGAAGTTGGTATGGACCAGGGTACCGCGCTG

GCGTTCCAGAAACCGACCGAATCTGAACCGTTCAAAATCAAACCGTTCTCTGCGC

AGTACGGTCCGGTTCTGTGGCTGAACTCTTCTTCTTACTCTCAGTCTCAGTACCT

GGACGGTTTCCTGTCTCAGCCGAAAAACTGGTCTATGCGTGTTCTGCCGCAGGCG

GGTTCTGTTCGTGTTGAACAGCGTGTTGCGCTGATCTGGAACCTGCAGGCGGGTA

AAATGCGTCTGGAACGTTCTGGTGCGCGTGCGTTCTTCATGCCGGTTCCGTTCTC

TTTCCGTCCGTCTGGTTCTGGTGACGAAGCGGTTCTGGCGCCGAACCGTTACCTG

GGTCTGTTCCCGCACTCTGGTGGTATCGAATACGCGGTTGTTGACGTTCTGGACT

CTGCGGGTTTCAAAATCCTGGAACGTGGTACCATCGCGGTTAACGGTTTCTCTCA

GAAACGTGGTGAACGTCAGGAAGAAGCGCACCGTGAAAAACAGCGTCGTGGTATC

TCTGACATCGGTCGTAAAAAACCGGTTCAGGCGGAAGTTGACGCGGCGAACGAAC

TGCACCGTAAATACACCGACGTTGCGACCCGTCTGGGTTGCCGTATCGTTGTTCA

GTGGGCGCCGCAGCCGAAACCGGGTACCGCGCCGACCGCGCAGACCGTTTACGCG

CGTGCGGTTCGTACCGAAGCGCCGCGTTCTGGTAACCAGGAAGACCACGCGCGTA

TGAAATCTTCTTGGGGTTACACCTGGGGTACCTACTGGGAAAAACGTAAACCGGA

AGACATCCTGGGTATCTCTACCCAGGTTTACTGGACCGGTGGTATCGGTGAATCT

TGCCCGGCGGTTGCGGTTGCGCTGCTGGGTCACATCCGTGCGACCTCTACCCAGA

CCGAATGGGAAAAAGAAGAAGTTGTTTTCGGTCGTCTGAAAAAATTCTTCCCGTC

TTAA

SEQ
ATGGAAAAACGTATCAACAAAATCCGTAAAAAACTGTCTGCGGACAACGCGACCA

ID
AACCGGTTTCTCGTTCTGGTCCGATGAAAACCCTGCTGGTTCGTGTTATGACCGA

NO:
CGACCTGAAAAAACGTCTGGAAAAACGTCGTAAAAAACCGGAAGTTATGCCGCAG

59
GTTATCTCTAACAACGCGGCGAACAACCTGCGTATGCTGCTGGACGACTACACCA

AAATGAAAGAAGCGATCCTGCAGGTTTACTGGCAGGAATTCAAAGACGACCACGT

TGGTCTGATGTGCAAATTCGCGCAGCCGGCGTCTAAAAAAATCGACCAGAACAAA

CTGAAACCGGAAATGGACGAAAAAGGTAACCTGACCACCGCGGGTTTCGCGTGCT

CTCAGTGCGGTCAGCCGCTGTTCGTTTACAAACTGGAACAGGTTTCTGAAAAAGG

TAAAGCGTACACCAACTACTTCGGTCGTTGCAACGTTGCGGAACACGAAAAACTG

ATCCTGCTGGCGCAGCTGAAACCGGAAAAAGACTCTGACGAAGCGGTTACCTACT

CTCTGGGTAAATTCGGTCAGCGTGCGCTGGACTTCTACTCTATCCACGTTACCAA

AGAATCTACCCACCCGGTTAAACCGCTGGCGCAGATCGCGGGTAACCGTTACGCG

TCTGGTCCGGTTGGTAAAGCGCTGTCTGACGCGTGCATGGGTACCATCGCGTCTT

TCCTGTCTAAATACCAGGACATCATCATCGAACACCAGAAAGTTGTTAAAGGTAA

CCAGAAACGTCTGGAATCTCTGCGTGAACTGGCGGGTAAAGAAAACCTGGAATAC

CCGTCTGTTACCCTGCCGCCGCAGCCGCACACCAAAGAAGGTGTTGACGCGTACA

ACGAAGTTATCGCGCGTGTTCGTATGTGGGTTAACCTGAACCTGTGGCAGAAACT

GAAACTGTCTCGTGACGACGCGAAACCGCTGCTGCGTCTGAAAGGTTTCCCGTCT

TTCCCGGTTGTTGAACGTCGTGAAAACGAAGTTGACTGGTGGAACACCATCAACG

AAGTTAAAAAACTGATCGACGCGAAACGTGACATGGGTCGTGTTTTCTGGTCTGG

TGTTACCGCGGAAAAACGTAACACCATCCTGGAAGGTTACAACTACCTGCCGAAC

GAAAACGACCACAAAAAACGTGAAGGTTCTCTGGAAAACCCGAAAAAACCGGCGA

AACGTCAGTTCGGTGACCTGCTGCTGTACCTGGAAAAAAAATACGCGGGTGACTG

GGGTAAAGTTTTCGACGAAGCGTGGGAACGTATCGACAAAAAAATCGCGGGTCTG

ACCTCTCACATCGAACGTGAAGAAGCGCGTAACGCGGAAGACGCGCAGTCTAAAG

CGGTTCTGACCGACTGGCTGCGTGCGAAAGCGTCTTTCGTTCTGGAACGTCTGAA

AGAAATGGACGAAAAAGAATTCTACGCGTGCGAAATCCAGCTGCAGAAATGGTAC

GGTGACCTGCGTGGTAACCCGTTCGCGGTTGAAGCGGAAAACCGTGTTGTTGACA

TCTCTGGTTTCTCTATCGGTTCTGACGGTCACTCTATCCAGTACCGTAACCTGCT

GGCGTGGAAATACCTGGAAAACGGTAAACGTGAATTCTACCTGCTGATGAACTAC

GGTAAAAAAGGTCGTATCCGTTTCACCGACGGTACCGACATCAAAAAATCTGGTA

AATGGCAGGGTCTGCTGTACGGTGGTGGTAAAGCGAAAGTTATCGACCTGACCTT

CGACCCGGACGACGAACAGCTGATCATCCTGCCGCTGGCGTTCGGTACCCGTCAG

GGTCGTGAATTCATCTGGAACGACCTGCTGTCTCTGGAAACCGGTCTGATCAAAC

TGGCGAACGGTCGTGTTATCGAAAAAACCATCTACAACAAAAAAATCGGTCGTGA

CGAACCGGCGCTGTTCGTTGCGCTGACCTTCGAACGTCGTGAAGTTGTTGACCCG

TCTAACATCAAACCGGTTAACCTGATCGGTGTTGACCGTGGTGAAAACATCCCGG

CGGTTATCGCGCTGACCGACCCGGAAGGTTGCCCGCTGCCGGAATTCAAAGACTC

TTCTGGTGGTCCGACCGACATCCTGCGTATCGGTGAAGGTTACAAAGAAAAACAG

CGTGCGATCCAGGCGGCGAAAGAAGTTGAACAGCGTCGTGCGGGTGGTTACTCTC

GTAAATTCGCGTCTAAATCTCGTAACCTGGCGGACGACATGGTTCGTAACTCTGC

GCGTGACCTGTTCTACCACGCGGTTACCCACGACGCGGTTCTGGTTTTCGAAAAC

CTGTCTCGTGGTTTCGGTCGTCAGGGTAAACGTACCTTCATGACCGAACGTCAGT

ACACCAAAATGGAAGACTGGCTGACCGCGAAACTGGCGTACGAAGGTCTGACCTC

TAAAACCTACCTGTCTAAAACCCTGGCGCAGTACACCTCTAAAACCTGCTCTAAC

TGCGGTTTCACCATCACCACCGCGGACTACGACGGTATGCTGGTTCGTCTGAAAA

AAACCTCTGACGGTTGGGCGACCACCCTGAACAACAAAGAACTGAAAGCGGAAGG

TCAGATCACCTACTACAACCGTTACAAACGTCAGACCGTTGAAAAAGAACTGTCT

GCGGAACTGGACCGTCTGTCTGAAGAATCTGGTAACAACGACATCTCTAAATGGA

CCAAAGGTCGTCGTGACGAAGCGCTGTTCCTGCTGAAAAAACGTTTCTCTCACCG

TCCGGTTCAGGAACAGTTCGTTTGCCTGGACTGCGGTCACGAAGTTCACGCGGAC

GAACAGGCGGCGCTGAACATCGCGCGTTCTTGGCTGTTCCTGAACTCTAACTCTA

CCGAATTCAAATCTTACAAATCTGGTAAACAGCCGTTCGTTGGTGCGTGGCAGGC

GTTCTACAAACGTCGTCTGAAAGAAGTTTGGAAACCGAACGCG

SEQ
ATGAAACGTATCAACAAAATCCGTCGTCGTCTGGTTAAAGACTCTAACACCAAAA

ID
AAGCGGGTAAAACCGGTCCGATGAAAACCCTGCTGGTTCGTGTTATGACCCCGGA

NO:
CCTGCGTGAACGTCTGGAAAACCTGCGTAAAAAACCGGAAAACATCCCGCAGCCG

60
ATCTCTAACACCTCTCGTGCGAACCTGAACAAACTGCTGACCGACTACACCGAAA

TGAAAAAAGCGATCCTGCACGTTTACTGGGAAGAATTCCAGAAAGACCCGGTTGG

TCTGATGTCTCGTGTTGCGCAGCCGGCGCCGAAAAACATCGACCAGCGTAAACTG

ATCCCGGTTAAAGACGGTAACGAACGTCTGACCTCTTCTGGTTTCGCGTGCTCTC

AGTGCTGCCAGCCGCTGTACGTTTACAAACTGGAACAGGTTAACGACAAAGGTAA

ACCGCACACCAACTACTTCGGTCGTTGCAACGTTTCTGAACACGAACGTCTGATC

CTGCTGTCTCCGCACAAACCGGAAGCGAACGACGAACTGGTTACCTACTCTCTGG

GTAAATTCGGTCAGCGTGCGCTGGACTTCTACTCTATCCACGTTACCCGTGAATC

TAACCACCCGGTTAAACCGCTGGAACAGATCGGTGGTAACTCTTGCGCGTCTGGT

CCGGTTGGTAAAGCGCTGTCTGACGCGTGCATGGGTGCGGTTGCGTCTTTCCTGA

CCAAATACCAGGACATCATCCTGGAACACCAGAAAGTTATCAAAAAAAACGAAAA

ACGTCTGGCGAACCTGAAAGACATCGCGTCTGCGAACGGTCTGGCGTTCCCGAAA

ATCACCCTGCCGCCGCAGCCGCACACCAAAGAAGGTATCGAAGCGTACAACAACG

TTGTTGCGCAGATCGTTATCTGGGTTAACCTGAACCTGTGGCAGAAACTGAAAAT

CGGTCGTGACGAAGCGAAACCGCTGCAGCGTCTGAAAGGTTTCCCGTCTTTCCCG

CTGGTTGAACGTCAGGCGAACGAAGTTGACTGGTGGGACATGGTTTGCAACGTTA

AAAAACTGATCAACGAAAAAAAAGAAGACGGTAAAGTTTTCTGGCAGAACCTGGC

GGGTTACAAACGTCAGGAAGCGCTGCTGCCGTACCTGTCTTCTGAAGAAGACCGT

AAAAAAGGTAAAAAATTCGCGCGTTACCAGTTCGGTGACCTGCTGCTGCACCTGG

AAAAAAAACACGGTGAAGACTGGGGTAAAGTTTACGACGAAGCGTGGGAACGTAT

CGACAAAAAAGTTGAAGGTCTGTCTAAACACATCAAACTGGAAGAAGAACGTCGT

TCTGAAGACGCGCAGTCTAAAGCGGCGCTGACCGACTGGCTGCGTGCGAAAGCGT

CTTTCGTTATCGAAGGTCTGAAAGAAGCGGACAAAGACGAATTCTGCCGTTGCGA

ACTGAAACTGCAGAAATGGTACGGTGACCTGCGTGGTAAACCGTTCGCGATCGAA

GCGGAAAACTCTATCCTGGACATCTCTGGTTTCTCTAAACAGTACAACTGCGCGT

TCATCTGGCAGAAAGACGGTGTTAAAAAACTGAACCTGTACCTGATCATCAACTA

CTTCAAAGGTGGTAAACTGCGTTTCAAAAAAATCAAACCGGAAGCGTTCGAAGCG

AACCGTTTCTACACCGTTATCAACAAAAAATCTGGTGAAATCGTTCCGATGGAAG

TTAACTTCAACTTCGACGACCCGAACCTGATCATCCTGCCGCTGGCGTTCGGTAA

ACGTCAGGGTCGTGAATTCATCTGGAACGACCTGCTGTCTCTGGAAACCGGTTCT

CTGAAACTGGCGAACGGTCGTGTTATCGAAAAAACCCTGTACAACCGTCGTACCC

GTCAGGACGAACCGGCGCTGTTCGTTGCGCTGACCTTCGAACGTCGTGAAGTTCT

GGACTCTTCTAACATCAAACCGATGAACCTGATCGGTATCGACCGTGGTGAAAAC

ATCCCGGCGGTTATCGCGCTGACCGACCCGGAAGGTTGCCCGCTGTCTCGTTTCA

AAGACTCTCTGGGTAACCCGACCCACATCCTGCGTATCGGTGAATCTTACAAAGA

AAAACAGCGTACCATCCAGGCGGCGAAAGAAGTTGAACAGCGTCGTGCGGGTGGT

TACTCTCGTAAATACGCGTCTAAAGCGAAAAACCTGGCGGACGACATGGTTCGTA

ACACCGCGCGTGACCTGCTGTACTACGCGGTTACCCAGGACGCGATGCTGATCTT

CGAAAACCTGTCTCGTGGTTTCGGTCGTCAGGGTAAACGTACCTTCATGGCGGAA

CGTCAGTACACCCGTATGGAAGACTGGCTGACCGCGAAACTGGCGTACGAAGGTC

TGCCGTCTAAAACCTACCTGTCTAAAACCCTGGCGCAGTACACCTCTAAAACCTG

CTCTAACTGCGGTTTCACCATCACCTCTGCGGACTACGACCGTGTTCTGGAAAAA

CTGAAAAAAACCGCGACCGGTTGGATGACCACCATCAACGGTAAAGAACTGAAAG

TTGAAGGTCAGATCACCTACTACAACCGTTACAAACGTCAGAACGTTGTTAAAGA

CCTGTCTGTTGAACTGGACCGTCTGTCTGAAGAATCTGTTAACAACGACATCTCT

TCTTGGACCAAAGGTCGTTCTGGTGAAGCGCTGTCTCTGCTGAAAAAACGTTTCT

CTCACCGTCCGGTTCAGGAAAAATTCGTTTGCCTGAACTGCGGTTTCGAAACCCA

CGCGGACGAACAGGCGGCGCTGAACATCGCGCGTTCTTGGCTGTTCCTGCGTTCT

CAGGAATACAAAAAATACCAGACCAACAAAACCACCGGTAACACCGACAAACGTG

CGTTCGTTGAAACCTGGCAGTCTTTCTACCGTAAAAAACTGAAAGAAGTTTGGAA

ACCG

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

61
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataa

tcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcc

atagcatttttatccataagattagcggatcctacctgacgctttttatcgcaac

tctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtg

agataggcggagatacgaactttaagAAGGAGatataccATGGGTAAAATGTATT

ACCTTGGTTTAGACATTGGCACGAATTCCGTGGGCTACGCGGTGACCGACCCCTC

ATACCACCTGCTGAAGTTTAAGGGGGAACCAATGTGGGGTGCGCACGTATTTGCC

GCCGGTAATCAGAGCGCGGAACGACGCTCGTTCCGCACATCGCGTCGTCGTTTGG

ACCGACGCCAACAGCGCGTTAAACTGGTACAGGAGATTTTTGCCCCGGTGATTAG

TCCGATCGACCCACGCTTCTTCATTCGTCTGCATGAATCCGCCCTGTGGCGCGAT

GACGTCGCGGAGACGGATAAACATATCTTTTTCAATGATCCTACCTATACCGATA

AGGAATATTATAGCGATTACCCGACTATCCATCACCTGATCGTTGATCTGATGGA

AAGCTCTGAGAAACACGATCCGCGGCTGGTGTACCTTGCAGTGGCGTGGTTAGTG

GCACACCGTGGTCATTTTCTGAACGAGGTGGACAAGGATAATATTGGAGATGTGT

TGTCGTTCGACGCATTTTATCCGGAGTTTCTCGCGTTCCTGTCGGACAACGGTGT

ATCACCGTGGGTGTGCGAAAGCAAAGCGCTGCAGGCGACCTTGCTGAGCCGTAAC

TCAGTGAACGACAAATATAAAGCCCTTAAGTCTCTGATCTTCGGATCCCAGAAAC

CTGAAGATAACTTCGATGCCAATATTTCGGAAGATGGACTCATTCAACTGCTGGC

CGGCAAAAAGGTAAAAGTTAACAAACTGTTCCCTCAGGAATCGAACGATGCATCC

TTCACATTGAATGATAAAGAAGACGCGATAGAAGAAATCCTGGGTACGCTTACAC

CAGATGAATGTGAATGGATTGCGCATATACGCCGCCTTTTTGACTGGGCTATCAT

GAAACATGCTCTGAAAGATGGCAGGACTATTAGCGAGTCAAAAGTCAAACTGTAT

GAGCAGCACCATCACGATCTGACCCAACTTAAATACTTCGTGAAAACCTACCTTG

CAAAAGAATACGACGATATTTTCCGCAACGTGGATAGCGAAACAACGAAAAACTA

TGTAGCGTATTCCTATCATGTGAAAGAGGTGAAAGGCACTCTGCCTAAAAATAAG

GCAACGCAAGAAGAGTTTTGTAAGTATGTCCTGGGCAAGGTTAAAAACATTGAAT

GCTCTGAAGCAGACAAGGTTGACTTTGATGAGATGATTCAGCGTCTTACCGACAA

CTCTTTTATGCCTAAGCAGGTTTCGGGCGAAAACCGCGTTATTCCTTATCAGTTA

TATTATTATGAACTGAAGACAATTCTGAATAAAGCAGCCTCGTACCTGCCTTTCC

TGACGCAGTGTGGAAAAGATGCAATTTCGAACCAGGACAAACTACTGTCGATCAT

GACGTTCCGTATTCCTTACTTCGTCGGACCCTTGCGAAAAGATAATTCGGAACAT

GCATGGCTCGAACGAAAGGCCGGTAAGATTTATCCGTGGAACTTTAACGACAAAG

TGGACTTGGATAAATCAGAAGAAGCGTTCATTCGCCGAATGACCAATACCTGTAC

CTATTATCCCGGCGAAGATGTTTTACCGTTGGATTCGCTGATCTATGAGAAATTT

ATGATTTTAAATGAAATCAATAATATTCGTATTGACGGCTACCCGATTAGTGTTG

ACGTTAAACAGCAGGTTTTTGGCTTGTTCGAAAAAAAACGACGCGTAACCGTGAA

AGATATTCAGAACCTGCTGCTGTCTCTCGGAGCTCTGGACAAACACGGGAAGCTG

ACAGGCATCGATACCACTATCCACTCAAACTATAATACGTATCACCATTTTAAAT

CTCTCATGGAACGCGGCGTCCTGACCCGGGATGACGTGGAACGCATCGTTGAAAG

GATGACCTACAGCGACGATACTAAGCGTGTGCGTCTGTGGCTGAATAACAACTAT

GGTACTTTAACCGCCGACGATGTGAAACACATTTCGCGTCTGCGCAAACACGATT

TTGGCCGTTTATCCAAAATGTTCTTAACAGGTCTGAAGGGTGTCCATAAGGAGAC

CGGTGAACGTGCCTCCATACTGGATTTCATGTGGAACACGAACGATAACCTGATG

CAGCTCCTTTCCGAATGCTACACGTTCAGTGATGAAATCACAAAGCTGCAAGAGG

CGTATTATGCAAAAGCCCAGTTGTCTTTAAACGATTTTTTAGACTCGATGTACAT

CTCTAACGCGGTGAAACGTCCGATTTACAGAACTCTGGCAGTGGTGAACGATATT

CGAAAAGCATGTGGGACGGCCCCTAAACGCATTTTCATCGAAATGGCTCGTGATG

GTGAATCAAAAAAAAAGAGAAGTGTTACACGTCGCGAGCAGATCAAAAACCTGTA

CCGCTCGATTCGTAAAGATTTCCAGCAGGAAGTTGATTTTCTGGAAAAGATCCTG

GAAAATAAATCTGATGGTCAACTTCAGTCAGATGCTTTGTATCTTTACTTTGCAC

AATTAGGGCGCGATATGTACACGGGCGATCCAATAAAGCTGGAGCACATCAAAGA

TCAGAGTTTCTATAACATAGACCATATTTACCCGCAGTCTATGGTGAAAGACGAT

TCCCTAGATAACAAAGTGCTGGTGCAAAGCGAAATTAACGGCGAGAAAAGCTCGC

GATACCCTTTGGACGCCGCGATCCGCAATAAAATGAAGCCCCTTTGGGACGCTTA

CTATAATCATGGCCTGATCTCCTTAAAGAAATACCAGCGTCTAACGCGCTCGACC

CCGTTTACCGATGATGAAAAATGGGACTTTATTAATCGCCAGTTAGTGGAAACCC

GTCAATCTACCAAAGCGCTGGCCATTTTGTTGAAGCGTAAGTTTCCAGACACCGA

AATTGTGTATTCGAAGGCGGGGTTATCGTCCGACTTCAGACATGAATTCGGCCTT

GTAAAAAGTCGCAATATTAATGATTTGCACCACGCTAAAGACGCATTCTTGGCTA

TCGTTACCGGCAATGTGTACCATGAAAGATTCAATCGCAGATGGTTTATGGTGAA

CCAGCCGTACTCAGTTAAAACTAAAACTCTTTTTACCCACAGCATAAAGAATGGC

AACTTCGTTGCCTGGAACGGCGAAGAAGATCTCGGTCGTATTGTAAAAATGCTGA

AGCAAAACAAAAATACCATTCACTTCACGCGCTTCTCCTTCGATCGCAAAGAAGG

ATTATTTGATATCCAACCTCTGAAAGCCAGCACCGGCTTAGTCCCACGAAAAGCC

GGTCTGGATGTCGTTAAATACGGCGGATATGACAAATCTACCGCGGCCTATTACC

TGCTGGTGAGGTTCACGCTCGAGGACAAGAAAACCCAGCACAAGCTGATGATGAT

TCCTGTAGAAGGCCTGTACAAGGCTCGCATTGATCATGACAAGGAATTTCTTACC

GATTATGCGCAAACGACTATAAGCGAAATCCTACAGAAAGATAAACAGAAAGTGA

TCAATATTATGTTTCCAATGGGTACGAGGCATATAAAACTCAATTCAATGATTAG

TATCGATGGCTTCTATCTTAGTATCGGCGGAAAGTCCTCTAAAGGTAAGTCAGTT

CTATGTCACGCAATGGTTCCACTGATCGTCCCTCACAAAATCGAATGTTACATTA

AAGCAATGGAAAGCTTCGCCCGGAAGTTTAAAGAAAACAACAAGCTGCGCATCGT

AGAAAAATTCGATAAAATCACCGTTGAAGACAACCTGAATCTCTACGAGCTCTTT

CTCCAAAAACTGCAGCATAATCCCTATAATAAGTTTTTTTCGACACAGTTTGACG

TACTGACGAACGGCCGTTCTACTTTCACAAAACTGTCGCCGGAGGAACAGGTACA

GACGCTCTTGAACATTTTAAGTATCTTTAAAACATGCCGCAGTTCGGGTTGCGAC

CTGAAATCCATCAACGGCAGTGCCCAGGCAGCGCGCATCATGATTAGCGCTGACT

TAACTGGACTGTCGAAAAAATATTCAGATATTAGGTTGGTTGAACAGTCAGCTTC

TGGTTTGTTCGTATCCAAAAGTCAGAACTTACTGGAGTATCTCTAAGAAATCATC

CTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATTTATTATATCGCGTTGATTA

TTGATGCTGTTTTTAGTTTTAACGGCAATTAATATATGTGTTATTAATTGAATGA

ATTTTATCATTCATAATAAGTATGTGTAGGATCAAGCTCAGGTTAAATATTCACT

CAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACAGAATTATCTCATAACAAGT

GTTAAGGGATGTTATTTCC

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

62
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataa

tcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcc

atagcatttttatccataagattagcggatcctacctgacgctttttatcgcaac

tctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtg

agataggcggagatacgaactttaagAAGGAGatataccATGTCATCGCTCACGA

AATTCACTAACAAATACTCTAAACAGCTCACCATTAAGAATGAACTCATCCCAGT

TGGCAAAACACTGGAGAACATCAAAGAGAATGGTCTGATAGATGGCGACGAACAG

CTGAATGAGAATTATCAGAAGGCGAAAATTATTGTGGATGATTTTCTGCGGGACT

TCATTAATAAAGCACTGAATAATACGCAGATCGGGAACTGGCGCGAACTGGCGGA

TGCCCTTAATAAAGAGGATGAAGATAACATCGAGAAATTGCAGGATAAAATTCGG

GGAATCATTGTATCCAAATTTGAAACGTTTGATCTGTTTAGCAGCTATTCTATTA

AGAAAGATGAAAAGATTATTGACGACGACAATGATGTTGAAGAAGAGGAACTGGA

TCTGGGCAAGAAGACCAGCTCATTTAAATACATATTTAAAAAAAACCTGTTTAAG

TTAGTGTTGCCATCCTACCTGAAAACCACAAACCAGGACAAGCTGAAGATTATTA

GCTCGTTTGATAATTTTTCAACGTACTTCCGCGGGTTCTTTGAAAACCGGAAAAA

CATTTTTACCAAGAAACCGATCTCCACAAGTATTGCGTATCGCATTGTTCATGAT

AACTTCCCGAAATTCCTTGATAACATTCGTTGTTTTAATGTGTGGCAGACGGAAT

GCCCGCAACTAATCGTGAAAGCAGATAACTATCTGAAAAGCAAAAATGTTATAGC

GAAAGATAAAAGTTTGGCAAACTATTTTACCGTGGGCGCGTATGACTATTTCCTG

TCTCAGAATGGTATAGATTTTTACAACAATATTATAGGTGGACTGCCAGCGTTCG

CCGGCCATGAGAAAATCCAAGGTCTCAATGAATTCATCAATCAAGAGTGCCAAAA

AGACAGCGAGCTGAAAAGTAAGCTGAAAAACCGTCACGCGTTCAAAATGGCGGTA

CTGTTCAAACAGATACTCAGCGATCGTGAAAAAAGTTTTGTAATTGATGAGTTCG

AGTCGGATGCTCAAGTTATTGACGCCGTTAAAAACTTTTACGCCGAACAGTGCAA

AGATAACAATGTTATTTTTAACTTATTAAATCTTATCAAGAATATCGCTTTCTTA

AGTGATGACGAACTGGACGGCATATTCATTGAAGGGAAATACCTGTCGAGCGTTA

GTCAAAAACTCTATAGCGATTGGTCAAAATTACGTAACGACATTGAGGATTCGGC

TAACTCTAAACAAGGCAATAAAGAGCTGGCCAAGAAGATCAAAACCAACAAAGGG

GATGTAGAAAAAGCGATCTCGAAATATGAGTTCTCGCTGTCGGAACTGAACTCGA

TTGTACATGATAACACCAAGTTTTCTGACCTCCTTAGTTGTACACTGCATAAGGT

GGCTTCTGAGAAACTGGTGAAGGTCAATGAAGGCGACTGGCCGAAACATCTCAAG

AATAATGAAGAGAAACAAAAAATCAAAGAGCCGCTTGATGCTCTGCTGGAGATCT

ATAATACACTTCTGATTTTTAACTGCAAAAGCTTCAATAAAAACGGCAACTTCTA

TGTCGACTATGATCGTTGCATCAATGAACTGAGTTCGGTCGTGTATCTGTATAAT

AAAACACGTAACTATTGCACTAAAAAACCCTATAACACGGACAAGTTCAAACTCA

ATTTTAACAGTCCGCAGCTCGGTGAAGGCTTTTCCAAGTCGAAAGAAAATGACTG

TCTGACTCTTTTGTTTAAAAAAGACGACAACTATTATGTAGGCATTATCCGCAAA

GGTGCAAAAATCAATTTTGATGATACACAAGCAATCGCCGATAACACCGACAATT

GCATCTTTAAAATGAATTATTTCCTACTTAAAGACGCAAAAAAATTTATCCCGAA

ATGTAGCATTCAGCTGAAAGAAGTCAAGGCCCATTTTAAGAAATCTGAAGATGAT

TACATTTTGTCTGATAAAGAGAAATTTGCTAGCCCGCTGGTCATTAAAAAGAGCA

CATTTTTGCTGGCAACTGCACATGTGAAAGGGAAAAAAGGCAATATCAAGAAATT

TCAGAAAGAATATTCGAAAGAAAACCCCACTGAGTATCGCAATTCTTTAAACGAA

TGGATTGCTTTTTGTAAAGAGTTCTTAAAAACTTATAAAGCGGCTACCATTTTTG

ATATAACCACATTGAAAAAGGCAGAGGAATATGCTGATATTGTAGAATTCTACAA

GGATGTCGATAATCTGTGCTACAAACTGGAGTTCTGCCCGATTAAAACCTCGTTT

ATAGAAAACCTGATAGATAACGGCGACCTGTATCTGTTTCGCATCAATAACAAAG

ACTTCAGCAGTAAATCGACCGGCACCAAGAACCTTCATACGTTATATTTACAAGC

TATATTCGATGAACGTAATCTGAACAATCCGACAATTATGCTGAATGGGGGAGCA

GAACTGTTCTATCGTAAAGAAAGTATTGAGCAGAAAAACCGTATCACACACAAAG

CCGGTTCAATTCTCGTGAATAAGGTGTGTAAAGACGGTACAAGCCTGGATGATAA

GATACGTAATGAAATTTATCAATATGAGAATAAATTTATTGATACCCTGTCTGAT

GAAGCTAAAAAGGTGTTACCGAATGTCATTAAAAAGGAAGCTACCCATGACATTA

CAAAAGATAAACGTTTCACTAGTGACAAATTCTTCTTTCACTGCCCCCTGACAAT

TAATTATAAGGAAGGCGATACCAAGCAGTTCAATAACGAAGTGCTGAGTTTTCTG

CGTGGAAATCCTGACATCAACATTATCGGCATTGACCGCGGAGAGCGTAATTTAA

TCTATGTAACGGTTATAAACCAGAAAGGCGAGATTCTGGATTCGGTTTCATTCAA

TACCGTGACCAACAAGAGTTCAAAAATCGAGCAGACAGTCGATTATGAAGAGAAA

TTGGCAGTCCGCGAGAAAGAGAGGATTGAAGCAAAACGTTCCTGGGACTCTATCT

CAAAAATTGCGACACTAAAGGAAGGTTATCTGAGCGCAATAGTTCACGAGATCTG

TCTGTTAATGATTAAACACAACGCGATCGTTGTCTTAGAGAATCTTAATGCAGGC

TTTAAGCGTATTCGTGGCGGTTTATCAGAAAAAAGTGTTTATCAAAAATTCGAAA

AAATGTTGATTAACAAACTGAACTATTTTGTCAGCAAGAAGGAATCCGACTGGAA

TAAACCGTCTGGTCTGCTGAATGGACTGCAGCTTTCGGATCAGTTTGAAAGCTTC

GAAAAACTGGGTATTCAGTCTGGTTTTATTTTTTACGTGCCGGCTGCATATACCT

CAAAGATTGATCCGACCACGGGCTTCGCCAATGTTCTGAATCTGTCGAAGGTACG

CAATGTTGATGCGATCAAAAGCTTTTTTTCTAACTTCAACGAAATTAGTTATAGC

AAGAAAGAAGCCCTTTTCAAATTCTCATTCGATCTGGATTCACTGAGTAAGAAAG

GCTTTAGTAGCTTTGTGAAATTTAGTAAGAGTAAATGGAACGTCTACACCTTTGG

AGAACGTATCATAAAGCCAAAGAATAAGCAAGGTTATCGGGAGGACAAAAGAATC

AACTTGACCTTCGAGATGAAGAAGTTACTTAACGAGTATAAGGTTTCTTTTGATC

TTGAAAATAACTTGATTCCGAATCTCACGAGTGCCAACCTGAAGGATACTTTTTG

GAAAGAGCTATTCTTTATCTTCAAGACTACGCTGCAGCTCCGTAACAGCGTTACT

AACGGTAAAGAAGATGTGCTCATCTCTCCGGTCAAAAATGCGAAGGGTGAATTCT

TCGTTTCGGGAACGCATAACAAGACTCTTCCGCAAGATTGCGATGCGAACGGTGC

ATACCATATTGCGTTGAAAGGTCTGATGATACTCGAACGTAACAACCTTGTACGT

GAGGAGAAAGATACGAAAAAGATTATGGCGATTTCAAACGTGGATTGGTTCGAGT

ACGTGCAGAAACGTAGAGGCGTTCTGTAAGAAATCATCCTTAGCGAAAGCTAAGG

ATTTTTTTTATCTGAAATTTATTATATCGCGTTGATTATTGATGCTGTTTTTAGT

TTTAACGGCAATTAATATATGTGTTATTAATTGAATGAATTTTATCATTCATAAT

AAGTATGTGTAGGATCAAGCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCA

GGAAGCAAAGAGGATTACAGAATTATCTCATAACAAGTGTTAAGGGATGTTATTT

CC

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

63
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATAACAACTACGACGAA

TTCACCAAACTGTACCCGATCCAGAAAACCATCCGTTTCGAACTGAAACCGCAGG

GTCGTACCATGGAACACCTGGAAACCTTCAACTTCTTCGAAGAAGACCGTGACCG

TGCGGAAAAATACAAAATCCTGAAAGAAGCGATCGACGAATACCACAAAAAATTC

ATCGACGAACACCTGACCAACATGTCTCTGGACTGGAACTCTCTGAAACAGATCT

CTGAAAAATACTACAAATCTCGTGAAGAAAAAGACAAAAAAGTTTTCCTGTCTGA

ACAGAAACGTATGCGTCAGGAAATCGTTTCTGAATTCAAAAAAGACGACCGTTTC

AAAGACCTGTTCTCTAAAAAACTGTTCTCTGAACTGCTGAAAGAAGAAATCTACA

AAAAAGGTAACCACCAGGAAATCGACGCGCTGAAATCTTTCGACAAATTCTCTGG

TTACTTCATCGGTCTGCACGAAAACCGTAAAAACATGTACTCTGACGGTGACGAA

ATCACCGCGATCTCTAACCGTATCGTTAACGAAAACTTCCCGAAATTCCTGGACA

ACCTGCAGAAATACCAGGAAGCGCGTAAAAAATACCCGGAATGGATCATCAAAGC

GGAATCTGCGCTGGTTGCGCACAACATCAAAATGGACGAAGTTTTCTCTCTGGAA

TACTTCAACAAAGTTCTGAACCAGGAAGGTATCCAGCGTTACAACCTGGCGCTGG

GTGGTTACGTTACCAAATCTGGTGAAAAAATGATGGGTCTGAACGACGCGCTGAA

CCTGGCGCACCAGTCTGAAAAATCTTCTAAAGGTCGTATCCACATGACCCCGCTG

TTCAAACAGATCCTGTCTGAAAAAGAATCTTTCTCTTACATCCCGGACGTTTTCA

CCGAAGACTCTCAGCTGCTGCCGTCTATCGGTGGTTTCTTCGCGCAGATCGAAAA

CGACAAAGACGGTAACATCTTCGACCGTGCGCTGGAACTGATCTCTTCTTACGCG

GAATACGACACCGAACGTATCTACATCCGTCAGGCGGACATCAACCGTGTTTCTA

ACGTTATCTTCGGTGAATGGGGTACCCTGGGTGGTCTGATGCGTGAATACAAAGC

GGACTCTATCAACGACATCAACCTGGAACGTACCTGCAAAAAAGTTGACAAATGG

CTGGACTCTAAAGAATTCGCGCTGTCTGACGTTCTGGAAGCGATCAAACGTACCG

GTAACAACGACGCGTTCAACGAATACATCTCTAAAATGCGTACCGCGCGTGAAAA

AATCGACGCGGCGCGTAAAGAAATGAAATTCATCTCTGAAAAAATCTCTGGTGAC

GAAGAATCTATCCACATCATCAAAACCCTGCTGGACTCTGTTCAGCAGTTCCTGC

ACTTCTTCAACCTGTTCAAAGCGCGTCAGGACATCCCGCTGGACGGTGCGTTCTA

CGCGGAATTCGACGAAGTTCACTCTAAACTGTTCGCGATCGTTCCGCTGTACAAC

AAAGTTCGTAACTACCTGACCAAAAACAACCTGAACACCAAAAAAATCAAACTGA

ACTTCAAAAACCCGACCCTGGCGAACGGTTGGGACCAGAACAAAGTTTACGACTA

CGCGTCTCTGATCTTCCTGCGTGACGGTAACTACTACCTGGGTATCATCAACCCG

AAACGTAAAAAAAACATCAAATTCGAACAGGGTTCTGGTAACGGTCCGTTCTACC

GTAAAATGGTTTACAAACAGATCCCGGGTCCGAACAAAAACCTGCCGCGTGTTTT

CCTGACCTCTACCAAAGGTAAAAAAGAATACAAACCGTCTAAAGAAATCATCGAA

GGTTACGAAGCGGACAAACACATCCGTGGTGACAAATTCGACCTGGACTTCTGCC

ACAAACTGATCGACTTCTTCAAAGAATCTATCGAAAAACACAAAGACTGGTCTAA

ATTCAACTTCTACTTCTCTCCGACCGAATCTTACGGTGACATCTCTGAATTCTAC

CTGGACGTTGAAAAACAGGGTTACCGTATGCACTTCGAAAACATCTCTGCGGAAA

CCATCGACGAATACGTTGAAAAAGGTGACCTGTTCCTGTTCCAGATCTACAACAA

AGACTTCGTTAAAGCGGCGACCGGTAAAAAAGACATGCACACCATCTACTGGAAC

GCGGCGTTCTCTCCGGAAAACCTGCAGGACGTTGTTGTTAAACTGAACGGTGAAG

CGGAACTGTTCTACCGTGACAAATCTGACATCAAAGAAATCGTTCACCGTGAAGG

TGAAATCCTGGTTAACCGTACCTACAACGGTCGTACCCCGGTTCCGGACAAAATC

CACAAAAAACTGACCGACTACCACAACGGTCGTACCAAAGACCTGGGTGAAGCGA

AAGAATACCTGGACAAAGTTCGTTACTTCAAAGCGCACTACGACATCACCAAAGA

CCGTCGTTACCTGAACGACAAAATCTACTTCCACGTTCCGCTGACCCTGAACTTC

AAAGCGAACGGTAAAAAAAACCTGAACAAAATGGTTATCGAAAAATTCCTGTCTG

ACGAAAAAGCGCACATCATCGGTATCGACCGTGGTGAACGTAACCTGCTGTACTA

CTCTATCATCGACCGTTCTGGTAAAATCATCGACCAGCAGTCTCTGAACGTTATC

GACGGTTTCGACTACCGTGAAAAACTGAACCAGCGTGAAATCGAAATGAAAGACG

CGCGTCAGTCTTGGAACGCGATCGGTAAAATCAAAGACCTGAAAGAAGGTTACCT

GTCTAAAGCGGTTCACGAAATCACCAAAATGGCGATCCAGTACAACGCGATCGTT

GTTATGGAAGAACTGAACTACGGTTTCAAACGTGGTCGTTTCAAAGTTGAAAAAC

AGATCTACCAGAAATTCGAAAACATGCTGATCGACAAAATGAACTACCTGGTTTT

CAAAGACGCGCCGGACGAATCTCCGGGTGGTGTTCTGAACGCGTACCAGCTGACC

AACCCGCTGGAATCTTTCGCGAAACTGGGTAAACAGACCGGTATCCTGTTCTACG

TTCCGGCGGCGTACACCTCTAAAATCGACCCGACCACCGGTTTCGTTAACCTGTT

CAACACCTCTTCTAAAACCAACGCGCAGGAACGTAAAGAATTCCTGCAGAAATTC

GAATCTATCTCTTACTCTGCGAAAGACGGTGGTATCTTCGCGTTCGCGTTCGACT

ACCGTAAATTCGGTACCTCTAAAACCGACCACAAAAACGTTTGGACCGCGTACAC

CAACGGTGAACGTATGCGTTACATCAAAGAAAAAAAACGTAACGAACTGTTCGAC

CCGTCTAAAGAAATCAAAGAAGCGCTGACCTCTTCTGGTATCAAATACGACGGTG

GTCAGAACATCCTGCCGGACATCCTGCGTTCTAACAACAACGGTCTGATCTACAC

CATGTACTCTTCTTTCATCGCGGCGATCCAGATGCGTGTTTACGACGGTAAAGAA

GACTACATCATCTCTCCGATCAAAAACTCTAAAGGTGAATTCTTCCGTACCGACC

CGAAACGTCGTGAACTGCCGATCGACGCGGACGCGAACGGTGCGTACAACATCGC

GCTGCGTGGTGAACTGACCATGCGTGCGATCGCGGAAAAATTCGACCCGGACTCT

GAAAAAATGGCGAAACTGGAACTGAAACACAAAGACTGGTTCGAATTCATGCAGA

CCCGTGGTGACTAAGAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTATCTGA

AATGTAGGGAGACCCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGGAAG

CAAAGAGGATTACA

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

64
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataa

tcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcc

atagcatttttatccataagattagcggatcctacctgacgctttttatcgcaac

tctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtg

agataggcggagatacgaactttaagAAGGAGatataccATGACTAAAACATTTG

ATTCAGAGTTTTTTAATTTGTACTCGCTGCAAAAAACGGTACGCTTTGAGTTAAA

ACCCGTGGGAGAAACCGCGTCATTTGTGGAAGACTTTAAAAACGAGGGCTTGAAA

CGTGTTGTGAGCGAAGATGAAAGGCGAGCCGTCGATTACCAGAAAGTTAAGGAAA

TAATTGACGATTACCATCGGGATTTCATTGAAGAAAGTTTAAATTATTTTCCGGA

ACAGGTGAGTAAAGATGCTCTTGAGCAGGCGTTTCATCTTTATCAGAAACTGAAG

GCAGCAAAAGTTGAGGAAAGGGAAAAAGCGCTGAAAGAATGGGAAGCGCTGCAGA

AAAAGCTACGTGAAAAAGTGGTGAAATGCTTCTCGGACTCGAATAAAGCCCGCTT

CTCAAGGATTGATAAAAAGGAACTGATTAAGGAAGACCTGATAAATTGGTTGGTC

GCCCAGAATCGCGAGGATGATATCCCTACGGTCGAAACGTTTAACAACTTCACCA

CATATTTTACCGGCTTCCATGAGAATCGTAAAAATATTTACTCCAAAGATGATCA

CGCCACCGCTATTAGCTTTCGCCTTATTCATGAAAATCTTCCAAAGTTTTTTGAC

AACGTGATTAGCTTCAATAAGTTGAAAGAGGGTTTCCCTGAATTAAAATTTGATA

AAGTGAAAGAGGATTTAGAAGTAGATTATGATCTGAAGCATGCGTTTGAAATAGA

ATATTTCGTTAACTTCGTGACCCAAGCGGGCATAGATCAGTATAATTATCTGTTA

GGAGGGAAAACCCTGGAGGACGGGACGAAAAAACAAGGGATGAATGAGCAAATTA

ATCTGTTCAAACAACAGCAAACGCGAGATAAAGCGCGTCAGATTCCCAAACTGAT

CCCCCTGTTCAAACAGATTCTTAGCGAAAGGACTGAAAGCCAGTCCTTTATTCCT

AAACAATTTGAAAGTGATCAGGAGTTGTTCGATTCACTGCAGAAGTTACATAATA

ACTGCCAGGATAAATTCACCGTGCTGCAACAAGCCATTCTCGGTCTGGCAGAGGC

GGATCTTAAGAAGGTCTTCATCAAAACCTCTGATTTAAATGCCTTATCTAACACC

ATTTTCGGGAATTACAGCGTCTTTTCCGATGCACTGAACCTGTATAAAGAAAGCC

TGAAAACGAAAAAAGCGCAGGAGGCTTTTGAGAAACTACCGGCCCATTCTATTCA

CGACCTCATTCAATACTTGGAACAGTTCAATTCCAGCCTGGACGCGGAAAAACAA

CAGAGCACCGACACCGTCCTGAACTACTTCATCAAGACCGATGAATTATATTCTC

GCTTCATTAAATCCACTAGCGAGGCTTTCACTCAGGTGCAGCCTTTGTTCGAACT

GGAAGCCCTGTCATCTAAGCGCCGCCCACCGGAATCGGAAGATGAAGGGGCAAAA

GGGCAGGAAGGCTTCGAGCAGATCAAGCGTATTAAAGCTTACCTGGATACGCTTA

TGGAAGCGGTACACTTTGCAAAGCCGTTGTATCTTGTTAAGGGTCGTAAAATGAT

CGAAGGGCTCGATAAAGACCAGTCCTTTTATGAAGCGTTTGAAATGGCGTACCAA

GAACTTGAATCGTTAATCATTCCTATCTATAACAAAGCGCGGAGCTATCTGTCGC

GGAAACCTTTCAAGGCCGATAAATTCAAGATTAATTTTGACAACAACACGCTACT

GAGCGGATGGGATGCGAACAAGGAAACTGCTAACGCGTCCATTCTGTTTAAGAAA

GACGGGTTATATTACCTTGGAATTATGCCGAAAGGTAAGACCTTTCTCTTTGACT

ACTTTGTATCGAGCGAGGATTCAGAGAAACTGAAACAGCGTCGCCAGAAGACCGC

CGAAGAAGCTCTGGCGCAGGATGGTGAAAGTTACTTCGAAAAAATTCGTTATAAA

CTGTTACCAGGGGCTTCAAAGATGTTACCGAAAGTCTTTTTTAGCAACAAAAATA

TTGGCTTTTACAACCCGTCGGATGACATTTTACGCATTCGCAACACAGCCTCTCA

CACCAAAAACGGGACCCCTCAGAAAGGCCACTCAAAAGTTGAGTTTAACCTGAAT

GATTGTCATAAGATGATTGATTTCTTCAAATCATCAATTCAGAAACACCCGGAAT

GGGGGTCTTTTGGCTTTACGTTTTCTGATACCAGTGATTTTGAAGACATGAGTGC

CTTCTACCGGGAAGTAGAAAACCAGGGTTACGTAATTAGCTTTGACAAAATCAAA

GAGACCTATATACAGAGCCAGGTGGAACAGGGTAATCTCTACTTATTCCAGATTT

ATAACAAGGATTTCTCGCCCTACAGCAAAGGCAAACCAAACCTGCATACTCTGTA

CTGGAAAGCCCTGTTTGAAGAAGCGAACCTGAATAACGTAGTGGCGAAGTTGAAC

GGTGAAGCGGAAATCTTCTTCCGTCGTCACTCCATTAAGGCCTCTGATAAAGTTG

TCCATCCGGCAAATCAGGCCATTGATAATAAGAATCCACACACGGAAAAAACGCA

GTCAACCTTTGAATATGACCTCGTTAAAGACAAACGCTACACGCAAGATAAGTTC

TTTTTCCACGTCCCAATCAGCCTCAACTTTAAAGCACAAGGGGTTTCAAAGTTTA

ATGATAAAGTCAATGGGTTCCTCAAGGGCAACCCGGATGTCAACATTATAGGTAT

AGACAGGGGCGAACGCCATCTGCTTTACTTTACCGTAGTGAATCAGAAAGGTGAA

ATACTGGTTCAGGAATCATTAAATACCTTGATGTCGGACAAAGGGCACGTTAATG

ATTACCAGCAGAAACTGGATAAAAAAGAACAGGAACGTGATGCTGCGCGTAAATC

GTGGACCACGGTTGAGAACATTAAAGAGCTGAAAGAGGGGTATCTAAGCCATGTG

GTACACAAACTGGCGCACCTCATCATTAAATATAACGCAATAGTCTGCCTAGAAG

ACTTGAATTTTGGCTTTAAACGCGGCCGCTTCAAAGTGGAAAAACAAGTTTATCA

AAAATTTGAAAAGGCGCTTATAGATAAACTGAATTATCTGGTTTTTAAAGAAAAG

GAACTTGGTGAGGTAGGGCACTACTTGACAGCTTATCAACTGACGGCCCCGTTCG

AATCATTCAAAAAACTGGGCAAACAGTCTGGCATTCTGTTTTACGTGCCGGCAGA

TTATACTTCAAAAATCGATCCAACAACTGGCTTTGTGAACTTCCTGGACCTGAGA

TATCAGTCTGTAGAAAAAGCTAAACAACTTCTTAGCGATTTTAATGCCATTCGTT

TTAACAGCGTTCAGAATTACTTTGAATTCGAAATTGACTATAAAAAACTTACTCC

GAAACGTAAAGTCGGAACCCAAAGTAAATGGGTAATTTGTACGTATGGCGATGTC

AGGTATCAGAACCGTCGGAATCAAAAAGGTCATTGGGAGACCGAAGAAGTGAACG

TGACCGAAAAGCTGAAGGCTCTGTTCGCCAGCGATTCAAAAACTACAACTGTGAT

CGATTACGCAAATGATGATAACCTGATAGATGTGATTTTAGAGCAGGATAAAGCC

AGCTTTTTTAAAGAACTGTTGTGGCTCCTGAAACTTACGATGACCTTACGACATT

CCAAGATCAAATCGGAAGATGATTTTATTCTGTCACCGGTCAAGAATGAGCAGGG

TGAATTCTATGATAGTAGGAAAGCCGGCGAAGTGTGGCCGAAAGACGCCGACGCC

AATGGCGCCTATCATATCGCGCTCAAAGGGCTTTGGAATTTGCAGCAGATTAACC

AGTGGGAAAAAGGTAAAACCCTGAATCTGGCTATCAAAAACCAGGATTGGTTTAG

CTTTATCCAAGAGAAACCGTATCAGGAATGAGAAATCATCCTTAGCGAAAGCTAA

GGATTTTTTTTATCTGAAATTTATTATATCGCGTTGATTATTGATGCTGTTTTTA

GTTTTAACGGCAATTAATATATGTGTTATTAATTGAATGAATTTTATCATTCATA

ATAAGTATGTGTAGGATCAAGCTCAGGTTAAATATTCACTCAGGAAGTTATTACT

CAGGAAGCAAAGAGGATTACAGAATTATCTCATAACAAGTGTTAAGGGATGTTAT

TTCC

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

65
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATCATACAGGCGGTCTT

CTTAGTATGGACGCGAAAGAGTTCACAGGTCAGTATCCGTTGTCGAAAACATTAC

GATTCGAACTTCGGCCCATCGGCCGCACGTGGGATAACCTGGAGGCCTCAGGCTA

CTTAGCGGAAGACCGCCATCGTGCCGAATGTTATCCTCGTGCGAAAGAGTTATTG

GATGACAACCATCGTGCCTTCCTGAATCGTGTGTTGCCACAAATCGATATGGATT

GGCACCCGATTGCGGAGGCCTTTTGTAAGGTACATAAAAACCCTGGTAATAAAGA

ACTTGCCCAGGATTACAACCTTCAGTTGTCAAAGCGCCGTAAGGAGATCAGCGCA

TATCTTCAGGATGCAGATGGCTATAAAGGCCTGTTCGCGAAGCCCGCCTTAGACG

AAGCTATGAAAATTGCGAAAGAAAACGGGAACGAAAGTGATATTGAGGTTCTCGA

AGCGTTTAACGGTTTTAGCGTATACTTCACCGGTTATCATGAGTCACGCGAGAAC

ATTTATAGCGATGAGGATATGGTGAGCGTAGCCTACCGAATTACTGAGGATAATT

TCCCGCGCTTTGTCTCAAACGCTTTGATCTTTGATAAATTAAACGAAAGCCATCC

GGATATTATCTCTGAAGTATCGGGCAATCTTGGAGTTGATGACATTGGTAAGTAC

TTTGACGTGTCGAACTATAACAATTTTCTTTCCCAGGCCGGTATAGATGACTACA

ATCACATTATTGGCGGCCATACAACCGAAGACGGACTGATACAAGCGTTTAATGT

CGTATTGAACTTACGTCACCAAAAAGACCCTGGCTTTGAAAAAATTCAGTTCAAA

CAGCTCTACAAACAAATCCTGAGCGTGCGTACCAGCAAAAGCTACATCCCGAAAC

AGTTTGACAACTCTAAGGAGATGGTTGACTGCATTTGCGATTATGTCAGCAAAAT

AGAGAAATCCGAAACAGTAGAACGGGCCCTGAAACTAGTCCGTAATATCAGTTCT

TTCGACTTGCGCGGGATCTTTGTCAATAAAAAGAACTTGCGCATACTGAGCAACA

AACTGATAGGAGATTGGGACGCGATCGAAACCGCATTGATGCATAGTTCTTCATC

AGAAAACGATAAGAAAAGCGTATATGATAGCGCGGAGGCTTTTACGTTGGATGAC

ATCTTTTCAAGCGTGAAAAAATTTTCTGATGCCTCTGCCGAAGATATTGGCAACA

GGGCGGAAGACATCTGTAGAGTGATAAGTGAGACGGCCCCTTTTATCAACGATCT

GCGAGCGGTGGACCTGGATAGCCTGAACGACGATGGTTATGAAGCGGCCGTCTCA

AAAATTCGGGAGTCGCTGGAGCCTTATATGGATCTTTTCCATGAACTGGAAATTT

TCTCGGTTGGCGATGAGTTCCCAAAATGCGCAGCATTTTACAGCGAACTGGAGGA

AGTCAGCGAACAGCTGATCGAAATTATTCCGTTATTCAACAAGGCGCGTTCGTTC

TGCACCCGGAAACGCTATAGCACCGATAAGATTAAAGTGAACTTAAAATTCCCGA

CCTTGGCGGACGGGTGGGACCTGAACAAAGAGAGAGACAACAAAGCCGCGATTCT

GCGGAAAGACGGTAAGTATTATCTGGCAATTCTGGATATGAAGAAAGATCTGTCA

AGCATTAGGACCAGCGACGAAGATGAATCCAGCTTCGAAAAGATGGAGTATAAAC

TGTTACCGAGTCCAGTAAAAATGCTGCCAAAGATATTCGTAAAATCGAAAGCCGC

TAAGGAAAAATATGGCCTGACAGATCGTATGCTTGAATGCTACGATAAAGGTATG

CATAAGTCGGGTAGTGCGTTTGATCTTGGCTTTTGCCATGAACTCATTGATTATT

ACAAGCGTTGTATCGCGGAGTACCCAGGCTGGGATGTGTTCGATTTCAAGTTTCG

CGAAACTTCCGATTATGGGTCCATGAAAGAGTTCAATGAAGATGTGGCCGGAGCC

GGTTACTATATGAGTCTGAGAAAAATTCCGTGCAGCGAAGTGTACCGTCTGTTAG

ACGAGAAATCGATTTATCTATTTCAAATTTATAACAAAGATTACTCTGAAAATGC

ACATGGTAATAAGAACATGCATACCATGTACTGGGAGGGTCTCTTTTCCCCGCAA

AACCTGGAGTCGCCCGTTTTCAAGTTGTCGGGTGGGGCAGAACTTTTCTTTCGAA

AATCCTCAATCCCTAACGATGCCAAAACAGTACACCCGAAAGGCTCAGTGCTGGT

TCCACGTAATGATGTTAACGGTCGGCGTATTCCAGATTCAATCTACCGCGAACTG

ACACGCTATTTTAACCGTGGCGATTGCCGAATCAGTGACGAAGCCAAAAGTTATC

TTGACAAGGTTAAGACTAAAAAAGCGGACCATGACATTGTGAAAGATCGCCGCTT

TACCGTGGATAAAATGATGTTCCACGTCCCGATTGCGATGAACTTTAAGGCGATC

AGTAAACCGAACTTAAACAAAAAAGTCATTGATGGCATCATTGATGATCAGGATC

TGAAAATCATTGGTATTGATCGTGGCGAGCGGAACTTAATTTACGTCACGATGGT

TGACAGAAAAGGGAATATCTTATATCAGGATTCTCTTAACATCCTCAATGGCTAC

GACTATCGTAAAGCTCTGGATGTGCGCGAATATGACAACAAGGAAGCGCGTCGTA

ACTGGACTAAAGTGGAGGGCATTCGCAAAATGAAGGAAGGCTATCTGTCATTAGC

GGTCTCGAAATTAGCGGATATGATTATCGAAAATAACGCCATCATCGTTATGGAG

GACCTGAACCACGGATTCAAAGCGGGCCGCTCAAAGATTGAAAAACAAGTTTATC

AGAAATTTGAGAGTATGCTGATTAACAAACTGGGCTATATGGTGTTAAAAGACAA

GTCAATTGACCAATCAGGTGGCGCGCTGCATGGATACCAGCTGGCGAACCATGTT

ACCACCTTAGCATCAGTTGGAAAGCAGTGTGGGGTTATCTTTTATATACCGGCAG

CGTTCACTAGTAAAATAGATCCGACCACTGGTTTCGCCGATCTCTTTGCCCTGAG

TAACGTTAAAAACGTAGCGAGCATGCGTGAATTCTTTTCCAAAATGAAATCTGTC

ATTTATGATAAAGCTGAAGGCAAATTCGCATTCACCTTTGATTACTTGGATTACA

ACGTGAAGAGCGAATGTGGTCGTACGCTGTGGACCGTTTACACCGTTGGTGAGCG

CTTCACCTATTCCCGTGTGAACCGCGAATATGTACGTAAAGTCCCCACCGATATT

ATCTATGATGCCCTCCAGAAAGCAGGCATTAGCGTCGAAGGAGACTTAAGGGACA

GAATTGCCGAAAGCGATGGCGATACGCTGAAGTCTATTTTTTACGCATTCAAATA

CGCGCTAGATATGCGCGTTGAGAATCGCGAGGAAGACTACATTCAATCACCTGTG

AAAAATGCCTCTGGGGAATTTTTTTGTTCAAAAAATGCTGGTAAAAGCCTCCCAC

AAGATAGCGATGCAAACGGTGCATATAACATTGCCCTGAAAGGTATTCTTCAATT

ACGCATGCTGTCTGAGCAGTACGACCCCAACGCGGAATCTATTAGACTTCCGCTG

ATAACCAATAAAGCCTGGCTGACATTCATGCAGTCTGGCATGAAGACCTGGAAAA

ATTAGGAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATGTAGGG

AGACCCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGGAAGCAAAGAGGA

TTACA

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

66
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataa

tcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcc

atagcatttttatccataagattagcggatcctacctgacgctttttatcgcaac

tctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtg

agataggcggagatacgaactttaagAAGGAGatataccatgGATAGTTTGAAAG

ATTTCACCAATCTGTACCCTGTCAGTAAGACATTGAGATTTGAATTAAAGCCCGT

TGGAAAGACTTTAGAAAATATCGAGAAAGCAGGTATTTTGAAAGAGGATGAGCAT

CGTGCAGAAAGTTATCGGAGGGTGAAGAAAATAATTGATACTTATCATAAGGTAT

TTATCGATTCTTCTCTTGAAAATATGGCTAAAATGGGTATTGAGAATGAAATAAA

AGCAATGCTCCAAAGTTTCTGCGAATTGTATAAAAAAGATCATCGCACTGAGGGT

GAAGACAAGGCATTAGATAAAATTCGAGCAGTACTTCGTGGCCTGATTGTTGGGG

CTTTCACTGGTGTTTGCGGAAGACGGGAAAATACAGTCCAAAACGAGAAGTACGA

GAGTTTGTTCAAAGAAAAGTTGATAAAAGAAATTTTACCTGATTTTGTGCTCTCT

ACTGAGGCTGAAAGCTTGCCTTTCTCTGTTGAAGAAGCTACGAGGTCACTGAAGG

AGTTTGATAGCTTTACATCCTACTTTGCTGGTTTTTACGAGAATAGAAAGAATAT

ATACTCGACGAAACCTCAATCCACTGCCATTGCTTATCGTCTTATTCATGAGAAC

TTGCCGAAGTTCATTGATAATATTCTTGTTTTTCAGAAGATCAAAGAGCCTATAG

CCAAAGAGCTGGAACATATTCGTGCGGACTTTTCTGCCGGGGGGTACATAAAAAA

GGATGAGAGATTGGAGGATATTTTTTCGTTGAACTATTATATCCACGTGTTATCT

CAGGCTGGGATCGAAAAATATAACGCATTGATTGGGAAGATTGTGACAGAAGGAG

ATGGAGAGATGAAAGGGCTCAATGAACACATCAACCTTTACAACCAACAAAGAGG

CAGAGAGGATCGGCTCCCTCTTTTTAGGCCTCTTTATAAACAGATATTGAGTGAC

AGAGAGCAATTATCATACTTGCCTGAGAGTTTTGAAAAAGATGAGGAGCTCCTCA

GGGCTCTAAAAGAGTTCTATGATCATATCGCAGAAGACATTCTCGGACGTACTCA

ACAGTTGATGACTTCTATTTCAGAATATGATTTATCTCGGATATACGTAAGGAAC

GATAGCCAATTGACTGATATATCAAAAAAAATGTTGGGAGATTGGAATGCTATCT

ACATGGCTAGAGAACGAGCATATGACCACGAGCAGGCTCCCAAAAGAATCACGGC

GAAATACGAGAGGGACAGGATTAAAGCTCTTAAAGGAGAAGAGAGTATAAGTCTG

GCAAATCTTAATAGTTGTATTGCCTTTCTGGACAATGTTAGAGATTGCCGTGTAG

ATACTTATCTTTCCACACTGGGCCAGAAGGAAGGACCACATGGTCTATCTAATCT

CGTTGAGAACGTTTTTGCCTCATACCATGAAGCAGAGCAATTGTTGAGCTTTCCA

TACCCCGAAGAGAATAATCTGATTCAGGACAAGGACAATGTGGTGTTAATTAAGA

ATCTTCTCGACAATATCAGTGATCTGCAGAGGTTCTTGAAACCTCTTTGGGGTAT

GGGAGACGAACCCGATAAAGATGAAAGATTTTATGGAGAGTATAATTATATCCGA

GGAGCTCTAGATCAGGTGATCCCTCTGTACAATAAGGTAAGGAACTACCTCACTC

GGAAGCCTTATTCGACCAGAAAAGTAAAACTCAATTTTGGGAATTCTCAATTGCT

TAGTGGTTGGGATAGAAATAAGGAAAAGGATAATAGCTGTGTGATTTTGCGTAAG

GGGCAGAACTTCTATTTGGCTATTATGAACAATAGGCACAAAAGAAGTTTCGAAA

ACAAGGTGTTGCCCGAGTATAAGGAGGGAGAACCTTACTTCGAAAAGATGGATTA

TAAATTTTTGCCTGATCCTAATAAAATGCTTCCTAAGGTTTTTCTTTCGAAAAAA

GGAATAGAGATATACAAACCAAGTCCGAAGCTTTTAGAACAATATGGACATGGAA

CTCACAAAAAGGGAGATACCTTTAGTATGGATGATTTGCACGAACTGATCGATTT

CTTCAAACACTCAATCGAGGCTCATGAAGATTGGAAGCAATTCGGATTCAAATTT

TCTGATACGGCTACTTATGAGAATGTATCTAGTTTCTATAGAGAAGTTGAGGATC

AGGGGTATAAGCTCTCTTTCCGAAAAGTTTCGGAATCTTATGTCTATTCATTAAT

AGATCAAGGCAAGTTGTATTTATTTCAGATATACAACAAGGACTTTTCTCCCTGC

AGCAAAGGGACACCTAATCTGCATACCTTGTATTGGAGAATGCTTTTTGACGAGC

GCAATTTGGCAGATGTCATATACAAACTGGATGGGAAGGCTGAAATCTTTTTCCG

AGAGAAGAGTTTGAAAAATGATCATCCCACGCATCCGGCTGGTAAGCCTATCAAA

AAGAAAAGTCGACAAAAAAAAGGAGAGGAGAGTCTGTTTGAGTATGATTTAGTCA

AGGATAGGCACTATACGATGGATAAGTTCCAGTTTCATGTGCCTATTACTATGAA

TTTTAAATGTTCTGCAGGAAGCAAAGTCAATGATATGGTTAATGCTCATATTCGA

GAGGCAAAGGATATGCATGTCATTGGAATTGATCGTGGAGAACGCAATCTGCTGT

ATATATGCGTGATAGATAGTCGAGGGACGATTTTGGATCAAATTTCTCTGAATAC

GATTAACGATATAGACTATCATGATTTATTGGAGAGTCGAGACAAAGACCGTCAG

CAGGAGCGCCGAAACTGGCAAACTATCGAAGGGATCAAGGAGCTAAAACAAGGCT

ACCTTAGTCAGGCGGTTCATCGGATAGCCGAACTGATGGTGGCTTATAAGGCTGT

AGTTGCTTTGGAGGATTTGAATATGGGGTTCAAACGTGGGCGGCAGAAAGTAGAA

AGTTCTGTTTATCAGCAGTTTGAGAAACAGCTGATAGATAAGCTCAACTATCTTG

TGGACAAGAAGAAAAGGCCTGAAGATATTGGAGGATTGTTGAGAGCCTATCAATT

TACGGCCCCATTTAAGAGTTTTAAGGAAATGGGAAAGCAAAACGGCTTCTTGTTT

TATATCCCGGCTTGGAACACGAGCAACATAGATCCGACTACTGGATTTGTTAATT

TATTTCATGCCCAGTATGAAAATGTAGATAAAGCGAAGAGCTTCTTTCAAAAGTT

TGATTCAATTAGTTACAACCCGAAGAAAGACTGGTTTGAGTTTGCATTCGATTAT

AAAAACTTTACTAAAAAGGCTGAAGGAAGTCGTTCTATGTGGATATTATGCACAC

ATGGTTCCCGAATAAAGAATTTTAGAAATTCCCAGAAGAATGGTCAATGGGATTC

CGAAGAATTCGCCTTGACGGAGGCTTTTAAGTCTCTTTTTGTGCGATATGAGATA

GATTATACCGCTGATTTGAAAACAGCTATTGTGGACGAAAAGCAAAAAGACTTCT

TCGTGGATCTTCTGAAGCTATTCAAATTGACAGTACAGATGCGCAACAGCTGGAA

AGAGAAGGATTTGGATTATCTAATCTCTCCTGTAGCAGGGGCTGATGGCCGTTTC

TTCGATACAAGAGAGGGAAATAAAAGTCTGCCTAAGGATGCAGATGCCAATGGAG

CTTATAATATTGCCCTAAAAGGACTTTGGGCTCTACGCCAGATTCGGCAAACTTC

AGAAGGCGGTAAACTCAAATTGGCGATTTCCAATAAGGAATGGCTACAGTTTGTG

CAAGAGAGATCTTACGAGAAAGACtgaGAAATCATCCTTAGCGAAAGCTAAGGAT

TTTTTTTATCTGAAATTTATTATATCGCGTTGATTATTGATGCTGTTTTTAGTTT

TAACGGCAATTAATATATGTGTTATTAATTGAATGAATTTTATCATTCATAATAA

GTATGTGTAGGATCAAGCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGG

AAGCAAAGAGGATTACAGAATTATCTCATAACAAGTGTTAAGGGATGTTATTTCC

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

67
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataa

tcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcc

atagcatttttatccataagattagcggatcctacctgacgctttttatcgcaac

tctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtg

agataggcggagatacgaactttaagAAGGAGatataccATGAACAACGGCACAA

ATAATTTTCAGAACTTCATCGGGATCTCAAGTTTGCAGAAAACGCTGCGCAATGC

TCTGATCCCCACGGAAACCACGCAACAGTTCATCGTCAAGAACGGAATAATTAAA

GAAGATGAGTTACGTGGCGAGAACCGCCAGATTCTGAAAGATATCATGGATGACT

ACTACCGCGGATTCATCTCTGAGACTCTGAGTTCTATTGATGACATAGATTGGAC

TAGCCTGTTCGAAAAAATGGAAATTCAGCTGAAAAATGGTGATAATAAAGATACC

TTAATTAAGGAACAGACAGAGTATCGGAAAGCAATCCATAAAAAATTTGCGAACG

ACGATCGGTTTAAGAACATGTTTAGCGCCAAACTGATTAGTGACATATTACCTGA

ATTTGTCATCCACAACAATAATTATTCGGCATCAGAGAAAGAGGAAAAAACCCAG

GTGATAAAATTGTTTTCGCGCTTTGCGACTAGCTTTAAAGATTACTTCAAGAACC

GTGCAAATTGCTTTTCAGCGGACGATATTTCATCAAGCAGCTGCCATCGCATCGT

CAACGACAATGCAGAGATATTCTTTTCAAATGCGCTGGTCTACCGCCGGATCGTA

AAATCGCTGAGCAATGACGATATCAACAAAATTTCGGGCGATATGAAAGATTCAT

TAAAAGAAATGAGTCTGGAAGAAATATATTCTTACGAGAAGTATGGGGAATTTAT

TACCCAGGAAGGCATTAGCTTCTATAATGATATCTGTGGGAAAGTGAATTCTTTT

ATGAACCTGTATTGTCAGAAAAATAAAGAAAACAAAAATTTATACAAACTTCAGA

AACTTCACAAACAGATTCTATGCATTGCGGACACTAGCTATGAGGTCCCGTATAA

ATTTGAAAGTGACGAGGAAGTGTACCAATCAGTTAACGGCTTCCTTGATAACATT

AGCAGCAAACATATAGTCGAAAGATTACGCAAAATCGGCGATAACTATAACGGCT

ACAACCTGGATAAAATTTATATCGTGTCCAAATTTTACGAGAGCGTTAGCCAAAA

AACCTACCGCGACTGGGAAACAATTAATACCGCCCTCGAAATTCATTACAATAAT

ATCTTGCCGGGTAACGGTAAAAGTAAAGCCGACAAAGTAAAAAAAGCGGTTAAGA

ATGATTTACAGAAATCCATCACCGAAATAAATGAACTAGTGTCAAACTATAAGCT

GTGCAGTGACGACAACATCAAAGCGGAGACTTATATACATGAGATTAGCCATATC

TTGAATAACTTTGAAGCACAGGAATTGAAATACAATCCGGAAATTCACCTAGTTG

AATCCGAGCTCAAAGCGAGTGAGCTTAAAAACGTGCTGGACGTGATCATGAATGC

GTTTCATTGGTGTTCGGTTTTTATGACTGAGGAACTTGTTGATAAAGACAACAAT

TTTTATGCGGAACTGGAGGAGATTTACGATGAAATTTATCCAGTAATTAGTCTGT

ACAACCTGGTTCGTAACTACGTTACCCAGAAACCGTACAGCACGAAAAAGATTAA

ATTGAACTTTGGAATACCGACGTTAGCAGACGGTTGGTCAAAGTCCAAAGAGTAT

TCTAATAACGCTATCATACTGATGCGCGACAATCTGTATTATCTGGGCATCTTTA

ATGCGAAGAATAAACCGGACAAGAAGATTATCGAGGGTAATACGTCAGAAAATAA

GGGTGACTACAAAAAGATGATTTATAATTTGCTCCCGGGTCCCAACAAAATGATC

CCGAAAGTTTTCTTGAGCAGCAAGACGGGGGTGGAAACGTATAAACCGAGCGCCT

ATATCCTAGAGGGGTATAAACAGAATAAACATATCAAGTCTTCAAAAGACTTTGA

TATCACTTTCTGTCATGATCTGATCGACTACTTCAAAAACTGTATTGCAATTCAT

CCCGAGTGGAAAAACTTCGGTTTTGATTTTAGCGACACCAGTACTTATGAAGACA

TTTCCGGGTTTTATCGTGAGGTAGAGTTACAAGGTTACAAGATTGATTGGACATA

CATTAGCGAAAAAGACATTGATCTGCTGCAGGAAAAAGGTCAACTGTATCTGTTC

CAGATATATAACAAAGATTTTTCGAAAAAATCAACCGGGAATGACAACCTTCACA

CCATGTACCTGAAAAATCTTTTCTCAGAAGAAAATCTTAAGGATATCGTCCTGAA

ACTTAACGGCGAAGCGGAAATCTTCTTCAGGAAGAGCAGCATAAAGAACCCAATC

ATTCATAAAAAAGGCTCGATTTTAGTCAACCGTACCTACGAAGCAGAAGAAAAAG

ACCAGTTTGGCAACATTCAAATTGTGCGTAAAAATATTCCGGAAAACATTTATCA

GGAGCTGTACAAATACTTCAACGATAAAAGCGACAAAGAGCTGTCTGATGAAGCA

GCCAAACTGAAGAATGTAGTGGGACACCACGAGGCAGCGACGAATATAGTCAAGG

ACTATCGCTACACGTATGATAAATACTTCCTTCATATGCCTATTACGATCAATTT

CAAAGCCAATAAAACGGGTTTTATTAATGATAGGATCTTACAGTATATCGCTAAA

GAAAAAGACTTACATGTGATCGGCATTGATCGGGGCGAGCGTAACCTGATCTACG

TGTCCGTGATTGATACTTGTGGTAATATAGTTGAACAGAAAAGCTTTAACATTGT

AAACGGCTACGACTATCAGATAAAACTGAAACAACAGGAGGGCGCTAGACAGATT

GCGCGGAAAGAATGGAAAGAAATTGGTAAAATTAAAGAGATCAAAGAGGGCTACC

TGAGCTTAGTAATCCACGAGATCTCTAAAATGGTAATCAAATACAATGCAATTAT

AGCGATGGAGGATTTGTCTTATGGTTTTAAAAAAGGGCGCTTTAAGGTCGAACGG

CAAGTTTACCAGAAATTTGAAACCATGCTCATCAATAAACTCAACTATCTGGTAT

TTAAAGATATTTCGATTACCGAGAATGGCGGTCTCCTGAAAGGTTATCAGCTGAC

ATACATTCCTGATAAACTTAAAAACGTGGGTCATCAGTGCGGCTGCATTTTTTAT

GTGCCTGCTGCATACACGAGCAAAATTGATCCGACCACCGGCTTTGTGAATATCT

TTAAATTTAAAGACCTGACAGTGGACGCAAAACGTGAATTCATTAAAAAATTTGA

CTCAATTCGTTATGACAGTGAAAAAAATCTGTTCTGCTTTACATTTGACTACAAT

AACTTTATTACGCAAAACACGGTCATGAGCAAATCATCGTGGAGTGTGTATACAT

ACGGCGTGCGCATCAAACGTCGCTTTGTGAACGGCCGCTTCTCAAACGAAAGTGA

TACCATTGACATAACCAAAGATATGGAGAAAACGTTGGAAATGACGGACATTAAC

TGGCGCGATGGCCACGATCTTCGTCAAGACATTATAGATTATGAAATTGTTCAGC

ACATATTCGAAATTTTCCGTTTAACAGTGCAAATGCGTAACTCCTTGTCTGAACT

GGAGGACCGTGATTACGATCGTCTCATTTCACCTGTACTGAACGAAAATAACATT

TTTTATGACAGCGCGAAAGCGGGGGATGCACTTCCTAAGGATGCCGATGCAAATG

GTGCGTATTGTATTGCATTAAAAGGGTTATATGAAATTAAACAAATTACCGAAAA

TTGGAAAGAAGATGGTAAATTTTCGCGCGATAAACTCAAAATCAGCAATAAAGAT

TGGTTCGACTTTATCCAGAATAAGCGCTATCTCTAAGAAATCATCCTTAGCGAAA

GCTAAGGATTTTTTTTATCTGAAATTTATTATATCGCGTTGATTATTGATGCTGT

TTTTAGTTTTAACGGCAATTAATATATGTGTTATTAATTGAATGAATTTTATCAT

TCATAATAAGTATGTGTAGGATCAAGCTCAGGTTAAATATTCACTCAGGAAGTTA

TTACTCAGGAAGCAAAGAGGATTACAGAATTATCTCATAACAAGTGTTAAGGGAT

GTTATTTCC

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

68
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATACCAATAAATTCACT

AACCAGTATTCTCTCTCTAAGACCCTGCGCTTTGAACTGATTCCGCAGGGGAAAA

CCTTGGAGTTCATTCAAGAAAAAGGCCTCTTGTCTCAGGATAAACAGAGGGCTGA

ATCTTACCAAGAAATGAAGAAAACTATTGATAAGTTTCATAAATATTTCATTGAT

TTAGCCTTGTCTAACGCCAAATTAACTCACTTGGAAACGTATCTGGAGTTATACA

ACAAATCTGCCGAAACTAAGAAAGAACAGAAATTTAAAGACGATTTGAAAAAAGT

ACAGGACAATCTGCGTAAAGAAATTGTCAAATCCTTCAGTGACGGCGATGCTAAA

AGCATTTTTGCCATTCTGGACAAAAAAGAGTTGATTACTGTGGAATTAGAAAAGT

GGTTTGAAAACAATGAGCAGAAAGACATCTACTTCGATGAGAAATTCAAAACTTT

CACCACCTATTTTACAGGATTTCATCAAAACCGGAAGAACATGTACTCAGTAGAA

CCGAACTCCACGGCCATTGCGTATCGTTTGATCCATGAGAATCTGCCTAAATTTC

TGGAGAATGCGAAAGCCTTTGAAAAGATTAAGCAGGTCGAATCGCTGCAAGTGAA

TTTTCGTGAACTCATGGGCGAATTTGGTGACGAAGGTCTAATCTTCGTTAACGAA

CTGGAAGAAATGTTTCAGATTAATTACTACAATGACGTGCTATCGCAGAACGGTA

TCACAATCTACAATAGTATTATCTCAGGGTTCACAAAAAACGATATAAAATACAA

AGGCCTGAACGAGTATATCAATAACTACAACCAAACAAAGGACAAAAAGGATAGG

CTTCCGAAACTGAAGCAGTTATACAAACAGATTTTATCTGACAGAATCTCCCTGA

GCTTTCTGCCGGATGCTTTCACTGATGGGAAGCAGGTTCTGAAAGCGATTTTCGA

TTTTTATAAGATTAACTTACTGAGCTACACGATTGAAGGTCAAGAAGAATCTCAA

AACTTACTGCTCTTGATCCGTCAAACCATTGAAAATCTATCATCGTTCGATACGC

AGAAAATCTACCTCAAAAACGATACTCACCTGACTACGATCTCTCAGCAGGTTTT

CGGGGATTTTAGTGTATTTTCAACAGCTCTGAACTACTGGTATGAAACCAAAGTC

AATCCGAAATTCGAGACGGAATATTCTAAGGCCAACGAAAAAAAACGTGAGATTC

TTGATAAAGCTAAAGCCGTATTTACTAAACAGGATTACTTTTCTATTGCTTTCCT

GCAGGAAGTTTTATCGGAGTATATCCTGACCCTGGATCATACATCTGATATCGTT

AAAAAACACAGCAGCAATTGCATCGCTGACTATTTCAAAAACCACTTTGTCGCCA

AAAAAGAAAACGAAACAGACAAGACTTTCGATTTCATTGCTAACATCACCGCAAA

ATACCAGTGTATTCAGGGTATCTTGGAAAACGCCGACCAATACGAAGACGAACTG

AAACAAGATCAGAAGCTGATCGATAATTTAAAATTCTTCTTAGATGCAATCCTGG

AGCTGCTGCACTTCATCAAACCGCTTCATTTAAAGAGCGAGTCCATTACCGAAAA

GGACACCGCCTTCTATGACGTTTTTGAAAATTATTATGAAGCCCTCTCCTTGCTG

ACTCCGCTGTATAATATGGTACGCAATTACGTAACCCAGAAACCATATTCTACCG

AAAAAATTAAACTGAACTTTGAAAACGCACAGCTGCTCAACGGTTGGGACGCGAA

TAAAGAAGGTGACTACCTCACCACCATCCTGAAAAAAGATGGTAACTATTTTCTG

GCAATTATGGATAAGAAACATAATAAAGCATTCCAGAAATTTCCTGAAGGGAAAG

AAAATTACGAAAAGATGGTGTACAAACTCTTACCTGGAGTTAACAAAATGTTGCC

GAAAGTATTTTTTAGTAATAAGAACATCGCGTACTTTAACCCGTCCAAAGAACTG

CTGGAAAATTATAAAAAGGAGACGCATAAGAAAGGGGATACCTTTAACCTGGAAC

ATTGCCATACCTTAATAGACTTCTTCAAGGATTCCCTGAATAAACACGAGGATTG

GAAATATTTCGATTTTCAGTTTAGTGAGACCAAGTCATACCAGGATCTTAGCGGC

TTTTATCGCGAAGTAGAACACCAAGGCTATAAAATTAACTTCAAAAACATCGACA

GCGAATACATCGACGGTTTAGTTAACGAGGGCAAACTGTTTCTGTTCCAGATCTA

TTCAAAGGATTTTAGCCCGTTCTCTAAAGGCAAACCAAATATGCATACGTTGTAC

TGGAAAGCACTGTTTGAAGAGCAAAACCTGCAGAATGTGATTTATAAACTGAACG

GCCAAGCTGAGATTTTTTTCCGTAAAGCCTCGATTAAACCGAAAAATATCATCCT

TCATAAGAAGAAAATAAAGATCGCTAAAAAACACTTCATAGATAAAAAAACCAAA

ACCTCCGAAATAGTGCCTGTTCAAACAATTAAGAACTTGAATATGTACTACCAGG

GCAAGATATCGGAAAAGGAGTTGACTCAAGACGATCTTCGCTATATCGATAACTT

TTCGATTTTTAACGAAAAAAACAAGACGATCGACATCATCAAAGATAAACGCTTC

ACTGTAGATAAGTTCCAGTTTCATGTGCCGATTACTATGAACTTCAAAGCTACCG

GGGGTAGCTATATCAACCAAACGGTGTTGGAATACCTGCAGAATAACCCGGAAGT

CAAAATCATTGGGCTGGACCGCGGAGAACGTCACCTTGTGTACTTGACCTTAATC

GATCAGCAAGGCAACATCTTAAAACAAGAATCGCTGAATACCATTACGGATTCAA

AGATTAGCACCCCGTATCATAAGCTGCTCGATAACAAGGAGAATGAGCGCGACCT

GGCCCGTAAAAACTGGGGCACGGTGGAAAACATTAAGGAGTTAAAGGAGGGTTAT

ATTTCCCAGGTAGTGCATAAGATCGCCACTCTCATGCTCGAGGAAAATGCGATCG

TTGTCATGGAAGACTTAAACTTCGGATTTAAACGTGGGCGATTTAAAGTAGAGAA

ACAAATCTACCAGAAGTTAGAAAAAATGCTGATTGACAAATTAAATTACTTGGTC

CTAAAAGACAAACAGCCGCAAGAATTGGGTGGATTATACAACGCCCTCCAACTTA

CCAATAAATTCGAAAGTTTTCAGAAAATGGGTAAACAGTCAGGCTTTCTTTTTTA

TGTTCCTGCGTGGAACACATCCAAAATCGACCCTACAACCGGCTTCGTCAATTAC

TTCTATACTAAATATGAAAACGTCGACAAAGCAAAAGCATTCTTTGAAAAGTTCG

AAGCAATACGTTTTAACGCTGAGAAAAAATATTTCGAGTTCGAAGTCAAGAAATA

CTCAGACTTTAACCCCAAAGCTGAGGGCACACAGCAAGCGTGGACAATCTGCACC

TACGGCGAGCGCATCGAAACGAAGCGTCAAAAAGATCAGAATAACAAATTTGTTT

CAACACCTATCAACCTGACCGAGAAGATTGAAGACTTCTTAGGTAAAAATCAGAT

TGTTTATGGCGACGGTAACTGTATAAAATCTCAAATAGCCTCAAAGGATGATAAA

GCATTTTTCGAAACATTATTATATTGGTTCAAAATGACACTGCAGATGCGCAATA

GTGAGACGCGTACAGATATTGATTATCTTATCAGCCCGGTCATGAACGACAACGG

TACTTTTTACAACTCCAGAGACTATGAAAAACTTGAGAATCCAACTCTCCCCAAA

GATGCTGATGCGAACGGTGCTTATCACATCGCGAAAAAAGGTCTGATGCTGCTGA

ACAAAATCGACCAAGCCGATCTGACTAAGAAAGTTGACCTAAGCATTTCAAATCG

GGACTGGTTACAGTTTGTTCAAAAGAACAAATGAGAAATCATCCTTAGCGAAAGC

TAAGGATTTTTTTTATCTGAAATGTAGGGAGACCCTCAGGTTAAATATTCACTCA

GGAAGTTATTACTCAGGAAGCAAAGAGGATTACA

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

69
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataa

tcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcc

atagcatttttatccataagattagcggatcctacctgacgctttttatcgcaac

tctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtg

agataggcggagatacgaactttaagAAGGAGatataccATGGAACAGGAATATT

ATCTGGGCTTGGACATGGGCACCGGTTCCGTCGGCTGGGCTGTTACTGACAGTGA

ATATCACGTTCTAAGAAAGCATGGTAAGGCATTGTGGGGTGTAAGACTTTTCGAA

TCTGCTTCCACTGCTGAAGAGCGTAGAATGTTTAGAACGAGTCGACGTAGGCTAG

ACAGGCGCAATTGGAGAATCGAAATTTTACAAGAAATTTTTGCGGAAGAGATATC

TAAGAAAGACCCAGGCTTTTTCCTGAGAATGAAGGAATCTAAGTATTACCCTGAG

GATAAAAGAGATATAAATGGTAACTGTCCCGAATTGCCTTACGCATTATTTGTGG

ACGATGATTTTACCGATAAGGATTACCATAAAAAGTTCCCAACTATCTACCATTT

ACGCAAAATGTTAATGAATACAGAGGAAACCCCAGACATAAGACTAGTTTATCTG

GCAATACACCATATGATGAAACATAGAGGCCATTTCTTACTTTCCGGGGATATCA

ACGAAATCAAAGAGTTTGGTACCACATTTAGTAAGTTACTGGAAAACATAAAGAA

TGAAGAATTGGATTGGAACTTAGAACTCGGAAAAGAAGAATACGCGGTTGTCGAA

TCTATCCTGAAGGATAATATGCTGAATAGGTCGACCAAAAAAACTAGGCTGATCA

AAGCACTGAAAGCCAAATCTATCTGCGAAAAAGCTGTTTTAAATTTACTTGCTGG

TGGCACTGTTAAGTTATCAGACATTTTTGGTTTGGAAGAATTGAACGAAACCGAG

CGTCCAAAAATTAGTTTCGCTGATAATGGCTACGATGATTACATTGGTGAGGTGG

AAAACGAGTTGGGCGAACAATTTTATATTATAGAGACAGCTAAGGCAGTCTATGA

CTGGGCTGTTTTAGTAGAAATCCTTGGTAAATACACATCTATCTCCGAAGCGAAA

GTTGCTACTTACGAAAAGCACAAGTCCGATCTCCAGTTTTTGAAGAAAATTGTCA

GGAAATATCTGACTAAGGAAGAATATAAAGATATTTTCGTTAGTACCTCTGACAA

ACTGAAAAATTACTCCGCTTACATCGGGATGACCAAGATTAATGGCAAAAAAGTT

GATCTGCAAAGCAAAAGGTGTTCGAAGGAAGAATTTTATGATTTCATTAAAAAGA

ATGTCTTAAAAAAATTAGAAGGTCAGCCAGAATACGAATATTTGAAAGAAGAACT

GGAAAGAGAGACATTCTTACCAAAACAAGTCAACAGAGATAATGGGGTAATTCCA

TATCAAATTCACCTCTACGAATTAAAAAAAATTTTAGGCAATTTACGCGATAAAA

TTGACCTTATCAAAGAAAATGAGGATAAGCTGGTTCAACTCTTTGAATTCAGAAT

ACCCTATTATGTGGGCCCACTGAACAAGATTGATGACGGCAAAGAAGGTAAATTC

ACATGGGCCGTCCGCAAATCCAATGAAAAAATTTACCCATGGAACTTTGAAAATG

TAGTAGATATTGAAGCGTCTGCGGAGAAATTTATTCGAAGAATGACTAATAAATG

CACTTACTTGATGGGAGAGGATGTTCTGCCTAAAGACAGCTTATTATACAGCAAG

TACATGGTTCTAAACGAACTTAACAACGTTAAGTTGGACGGTGAGAAATTAAGTG

TAGAATTGAAACAAAGATTGTATACTGACGTCTTCTGCAAGTACAGAAAAGTGAC

AGTTAAAAAAATTAAGAATTACTTGAAGTGCGAAGGTATAATTTCTGGAAACGTA

GAGATTACTGGTATTGATGGTGATTTCAAAGCATCCCTAACAGCTTACCACGATT

TCAAGGAAATCCTGACAGGAACTGAACTCGCAAAAAAAGATAAAGAAAACATTAT

TACTAATATTGTTCTTTTCGGTGATGACAAGAAATTGTTGAAGAAAAGACTGAAT

AGACTTTACCCCCAGATTACTCCCAATCAACTTAAGAAAATTTGTGCTTTGTCTT

ACACAGGATGGGGTCGTTTTTCAAAAAAGTTCTTAGAAGAGATTACCGCACCTGA

TCCAGAAACAGGCGAAGTATGGAATATAATTACCGCCTTATGGGAATCGAACAAT

AATCTTATGCAACTTCTGAGCAATGAATATCGTTTCATGGAAGAAGTTGAGACTT

ACAACATGGGCAAACAGACGAAGACTTTATCCTATGAAACTGTGGAAAATATGTA

TGTATCACCTTCTGTCAAGAGACAAATTTGGCAAACCTTAAAAATTGTCAAAGAA

TTAGAAAAGGTAATGAAGGAGTCTCCTAAACGTGTGTTTATTGAAATGGCTAGAG

AAAAACAAGAGTCAAAAAGAACCGAGTCAAGAAAGAAGCAGTTAATCGATTTATA

TAAGGCTTGTAAAAACGAAGAGAAAGATTGGGTTAAAGAATTGGGGGACCAAGAG

GAACAAAAACTACGGTCGGATAAGTTGTATTTATACTATACGCAAAAGGGACGAT

GTATGTATTCCGGCGAGGTAATAGAATTGAAGGATTTATGGGACAATACAAAATA

TGACATAGACCATATATATCCCCAATCAAAAACGATGGACGATAGCTTGAACAAT

AGAGTACTCGTGAAAAAAAAATATAATGCGACCAAATCTGATAAGTATCCTCTGA

ATGAAAATATCAGACATGAAAGAAAGGGGTTCTGGAAGTCCTTGTTAGATGGTGG

GTTTATAAGCAAAGAAAAGTACGAGCGTCTAATAAGAAACACGGAGTTATCGCCA

GAAGAACTCGCTGGTTTTATTGAGAGGCAAATCGTGGAAACGAGACAATCTACCA

AAGCCGTTGCTGAGATCCTAAAGCAAGTTTTCCCAGAGTCGGAGATTGTCTATGT

CAAAGCTGGCACAGTGAGCAGGTTTAGGAAAGACTTCGAACTATTAAAGGTAAGA

GAAGTGAACGATTTACATCACGCAAAGGACGCTTACCTAAATATCGTTGTAGGTA

ACTCATATTATGTTAAATTTACCAAGAACGCCTCTTGGTTTATAAAGGAGAACCC

AGGTAGAACATATAACCTGAAAAAGATGTTCACCTCTGGTTGGAATATTGAGAGA

AACGGAGAAGTCGCATGGGAAGTTGGTAAGAAAGGGACTATAGTGACAGTAAAGC

AAATTATGAACAAAAATAATATCCTCGTTACAAGGCAGGTTCATGAAGCAAAGGG

CGGCCTTTTTGACCAACAAATTATGAAGAAAGGGAAAGGTCAAATTGCAATAAAA

GAAACCGATGAGAGACTAGCGTCAATAGAAAAGTATGGTGGCTATAATAAAGCTG

CGGGTGCATACTTTATGCTTGTTGAATCAAAAGACAAGAAAGGTAAGACTATTAG

AACTATAGAATTTATACCCCTGTACCTTAAAAACAAAATTGAATCGGATGAGTCA

ATCGCGTTAAATTTTCTAGAGAAAGGAAGGGGTTTAAAAGAACCAAAGATCCTGT

TAAAAAAGATTAAGATTGACACCTTGTTCGATGTAGATGGATTTAAAATGTGGTT

ATCTGGCAGAACAGGCGATAGACTTTTGTTTAAGTGCGCTAATCAATTAATTTTG

GATGAGAAAATCATTGTCACAATGAAAAAAATAGTTAAGTTTATTCAGAGAAGAC

AAGAAAACAGGGAGTTGAAATTATCTGATAAAGATGGTATCGACAATGAAGTTTT

AATGGAAATCTACAATACATTCGTTGATAAACTTGAAAATACCGTATATCGAATC

AGGTTAAGTGAACAAGCCAAAACATTAATTGATAAACAAAAAGAATTTGAAAGGC

TATCACTGGAAGACAAATCCTCCACCCTATTTGAAATTTTGCATATATTCCAGTG

CCAATCTTCAGCAGCTAATTTAAAAATGATTGGCGGACCTGGGAAAGCCGGCATC

CTAGTGATGAACAATAATATCTCCAAGTGTAACAAAATATCAATTATTAACCAAT

CTCCGACAGGTATTTTTGAAAATGAAATAGACTTGCTTAAGATATAAGAAATCAT

CCTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATTTATTATATCGCGTTGATT

ATTGATGCTGTTTTTAGTTTTAACGGCAATTAATATATGTGTTATTAATTGAATG

AATTTTATCATTCATAATAAGTATGTGTAGGATCAAGCTCAGGTTAAATATTCAC

TCAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACAGAATTATCTCATAACAAG

TGTTAAGGGATGTTATTTCC

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

70
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATTCTTTCGACTCTTTC

ACCAACCTGTACTCTCTGTCTAAAACCCTGAAATTCGAAATGCGTCCGGTTGGTA

ACACCCAGAAAATGCTGGACAACGCGGGTGTTTTCGAAAAAGACAAACTGATCCA

GAAAAAATACGGTAAAACCAAACCGTACTTCGACCGTCTGCACCGTGAATTCATC

GAAGAAGCGCTGACCGGTGTTGAACTGATCGGTCTGGACGAAAACTTCCGTACCC

TGGTTGACTGGCAGAAAGACAAAAAAAACAACGTTGCGATGAAAGCGTACGAAAA

CTCTCTGCAGCGTCTGCGTACCGAAATCGGTAAAATCTTCAACCTGAAAGCGGAA

GACTGGGTTAAAAACAAATACCCGATCCTGGGTCTGAAAAACAAAAACACCGACA

TCCTGTTCGAAGAAGCGGTTTTCGGTATCCTGAAAGCGCGTTACGGTGAAGAAAA

AGACACCTTCATCGAAGTTGAAGAAATCGACAAAACCGGTAAATCTAAAATCAAC

CAGATCTCTATCTTCGACTCTTGGAAAGGTTTCACCGGTTACTTCAAAAAATTCT

TCGAAACCCGTAAAAACTTCTACAAAAACGACGGTACCTCTACCGCGATCGCGAC

CCGTATCATCGACCAGAACCTGAAACGTTTCATCGACAACCTGTCTATCGTTGAA

TCTGTTCGTCAGAAAGTTGACCTGGCGGAAACCGAAAAATCTTTCTCTATCTCTC

TGTCTCAGTTCTTCTCTATCGACTTCTACAACAAATGCCTGCTGCAGGACGGTAT

CGACTACTACAACAAAATCATCGGTGGTGAAACCCTGAAAAACGGTGAAAAACTG

ATCGGTCTGAACGAACTGATCAACCAGTACCGTCAGAACAACAAAGACCAGAAAA

TCCCGTTCTTCAAACTGCTGGACAAACAGATCCTGTCTGAAAAAATCCTGTTCCT

GGACGAAATCAAAAACGACACCGAACTGATCGAAGCGCTGTCTCAGTTCGCGAAA

ACCGCGGAAGAAAAAACCAAAATCGTTAAAAAACTGTTCGCGGACTTCGTTGAAA

ACAACTCTAAATACGACCTGGCGCAGATCTACATCTCTCAGGAAGCGTTCAACAC

CATCTCTAACAAATGGACCTCTGAAACCGAAACCTTCGCGAAATACCTGTTCGAA

GCGATGAAATCTGGTAAACTGGCGAAATACGAAAAAAAAGACAACTCTTACAAAT

TCCCGGACTTCATCGCGCTGTCTCAGATGAAATCTGCGCTGCTGTCTATCTCTCT

GGAAGGTCACTTCTGGAAAGAAAAATACTACAAAATCTCTAAATTCCAGGAAAAA

ACCAACTGGGAACAGTTCCTGGCGATCTTCCTGTACGAATTCAACTCTCTGTTCT

CTGACAAAATCAACACCAAAGACGGTGAAACCAAACAGGTTGGTTACTACCTGTT

CGCGAAAGACCTGCACAACCTGATCCTGTCTGAACAGATCGACATCCCGAAAGAC

TCTAAAGTTACCATCAAAGACTTCGCGGACTCTGTTCTGACCATCTACCAGATGG

CGAAATACTTCGCGGTTGAAAAAAAACGTGCGTGGCTGGCGGAATACGAACTGGA

CTCTTTCTACACCCAGCCGGACACCGGTTACCTGCAGTTCTACGACAACGCGTAC

GAAGACATCGTTCAGGTTTACAACAAACTGCGTAACTACCTGACCAAAAAACCGT

ACTCTGAAGAAAAATGGAAACTGAACTTCGAAAACTCTACCCTGGCGAACGGTTG

GGACAAAAACAAAGAATCTGACAACTCTGCGGTTATCCTGCAGAAAGGTGGTAAA

TACTACCTGGGTCTGATCACCAAAGGTCACAACAAAATCTTCGACGACCGTTTCC

AGGAAAAATTCATCGTTGGTATCGAAGGTGGTAAATACGAAAAAATCGTTTACAA

ATTCTTCCCGGACCAGGCGAAAATGTTCCCGAAAGTTTGCTTCTCTGCGAAAGGT

CTGGAATTCTTCCGTCCGTCTGAAGAAATCCTGCGTATCTACAACAACGCGGAAT

TCAAAAAAGGTGAAACCTACTCTATCGACTCTATGCAGAAACTGATCGACTTCTA

CAAAGACTGCCTGACCAAATACGAAGGTTGGGCGTGCTACACCTTCCGTCACCTG

AAACCGACCGAAGAATACCAGAACAACATCGGTGAATTCTTCCGTGACGTTGCGG

AAGACGGTTACCGTATCGACTTCCAGGGTATCTCTGACCAGTACATCCACGAAAA

AAACGAAAAAGGTGAACTGCACCTGTTCGAAATCCACAACAAAGACTGGAACCTG

GACAAAGCGCGTGACGGTAAATCTAAAACCACCCAGAAAAACCTGCACACCCTGT

ACTTCGAATCTCTGTTCTCTAACGACAACGTTGTTCAGAACTTCCCGATCAAACT

GAACGGTCAGGCGGAAATCTTCTACCGTCCGAAAACCGAAAAAGACAAACTGGAA

TCTAAAAAAGACAAAAAAGGTAACAAAGTTATCGACCACAAACGTTACTCTGAAA

ACAAAATCTTCTTCCACGTTCCGCTGACCCTGAACCGTACCAAAAACGACTCTTA

CCGTTTCAACGCGCAGATCAACAACTTCCTGGCGAACAACAAAGACATCAACATC

ATCGGTGTTGACCGTGGTGAAAAACACCTGGTTTACTACTCTGTTATCACCCAGG

CGTCTGACATCCTGGAATCTGGTTCTCTGAACGAACTGAACGGTGTTAACTACGC

GGAAAAACTGGGTAAAAAAGCGGAAAACCGTGAACAGGCGCGTCGTGACTGGCAG

GACGTTCAGGGTATCAAAGACCTGAAAAAAGGTTACATCTCTCAGGTTGTTCGTA

AACTGGCGGACCTGGCGATCAAACACAACGCGATCATCATCCTGGAAGACCTGAA

CATGCGTTTCAAACAGGTTCGTGGTGGTATCGAAAAATCTATCTACCAGCAGCTG

GAAAAAGCGCTGATCGACAAACTGTCTTTCCTGGTTGACAAAGGTGAAAAAAACC

CGGAACAGGCGGGTCACCTGCTGAAAGCGTACCAGCTGTCTGCGCCGTTCGAAAC

CTTCCAGAAAATGGGTAAACAGACCGGTATCATCTTCTACACCCAGGCGTCTTAC

ACCTCTAAATCTGACCCGGTTACCGGTTGGCGTCCGCACCTGTACCTGAAATACT

TCTCTGCGAAAAAAGCGAAAGACGACATCGCGAAATTCACCAAAATCGAATTCGT

TAACGACCGTTTCGAACTGACCTACGACATCAAAGACTTCCAGCAGGCGAAAGAA

TACCCGAACAAAACCGTTTGGAAAGTTTGCTCTAACGTTGAACGTTTCCGTTGGG

ACAAAAACCTGAACCAGAACAAAGGTGGTTACACCCACTACACCAACATCACCGA

AAACATCCAGGAACTGTTCACCAAATACGGTATCGACATCACCAAAGACCTGCTG

ACCCAGATCTCTACCATCGACGAAAAACAGAACACCTCTTTCTTCCGTGACTTCA

TCTTCTACTTCAACCTGATCTGCCAGATCCGTAACACCGACGACTCTGAAATCGC

GAAAAAAAACGGTAAAGACGACTTCATCCTGTCTCCGGTTGAACCGTTCTTCGAC

TCTCGTAAAGACAACGGTAACAAACTGCCGGAAAACGGTGACGACAACGGTGCGT

ACAACATCGCGCGTAAAGGTATCGTTATCCTGAACAAAATCTCTCAGTACTCTGA

AAAAAACGAAAACTGCGAAAAAATGAAATGGGGTGACCTGTACGTTTCTAACATC

GACTGGGACAACTTCGTTGAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTAT

CTGAAATGTAGGGAGACCCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAG

GAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

71
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATAACAAATTCGAAAAC

TTCACCGGTCTGTACCCGATCTCTAAAACCCTGCGTTTCGAACTGATCCCGCAGG

GTAAAACCCTGGAATACATCGAAAAATCTGAAATCCTGGAAAACGACAACTACCG

TGCGGAAAAATACGAAGAAGTTAAAGACATCATCGACGGTTACCACAAATGGTTC

ATCAACGAAACCCTGCACGACCTGCACATCAACTGGTCTGAACTGAAAGTTGCGC

TGGAAAACAACCGTATCGAAAAATCTGACGCGTCTAAAAAAGAACTGCAGCGTGT

TCAGAAAATCAAACGTGAAGAAATCTACAACGCGTTCATCGAACACGAAGCGTTC

CAGTACCTGTTCAAAGAAAACCTGCTGTCTGACCTGCTGCCGATCCAGATCGAAC

AGTCTGAAGACCTGGACGCGGAAAAAAAAAAACAGGCGGTTGAAACCTTCAACCG

TTTCTCTACCTACTTCACCGGTTTCCACGAAAACCGTAAAAACATCTACTCTAAA

GAAGGTATCTCTACCTCTGTTACCTACCGTATCGTTCACGACAACTTCCCGAAAT

TCCTGGAAAACATGAAAGTTTTCGAAATCCTGCGTAACGAATGCCCGGAAGTTAT

CTCTGACACCGCGAACGAACTGGCGCCGTTCATCGACGGTGTTCGTATCGAAGAC

ATCTTCCTGATCGACTTCTTCAACTCTACCTTCTCTCAGAACGGTATCGACTACT

ACAACCGTATCCTGGGTGGTGTTACCACCGAAACCGGTGAAAAATACCGTGGTAT

CAACGAATTCACCAACCTGTACCGTCAGCAGCACCCGGAATTCGGTAAATCTAAA

AAAGCGACCAAAATGGTTGTTCTGTTCAAACAGATCCTGTCTGACCGTGACACCC

TGTCTTTCATCCCGGAAATGTTCGGTAACGACAAACAGGTTCAGAACTCTATCCA

GCTGTTCTACAACCGTGAAATCTCTCAGTTCGAAAACGAAGGTGTTAAAACCGAC

GTTTGCACCGCGCTGGCGACCCTGACCTCTAAAATCGCGGAATTCGACACCGAAA

AAATCTACATCCAGCAGCCGGAACTGCCGAACGTTTCTCAGCGTCTGTTCGGTTC

TTGGAACGAACTGAACGCGTGCCTGTTCAAATACGCGGAACTGAAATTCGGTACC

GCGGAAAAAGTTGCGAACCGTAAAAAAATCGACAAATGGCTGAAATCTGACCTGT

TCTCTTTCACCGAACTGAACAAAGCGCTGGAATTCTCTGGTAAAGACGAACGTAT

CGAAAACTACTTCTCTGAAACCGGTATCTTCGCGCAGCTGGTTAAAACCGGTTTC

GACGAAGCGCAGTCTATCCTGGAAACCGAATACACCTCTGAAGTTCACCTGAAAG

ACCAGCAGACCGACATCGAAAAAATCAAAACCTTCCTGGACGCGCTGCAGAACCT

GATGCACCTGCTGAAATCTCTGTGCGTTTCTGAAGAAGCGGACCGTGACGCGGCG

TTCTACAACGAATTCGACATGCTGTACAACCAGCTGAAACTGGTTGTTCCGCTGT

ACAACAAAGTTCGTAACTACATCACCCAGAAACTGTTCCGTTCTGACAAAATCAA

AATCTACTTCGAAAACAAAGGTCAGTTCCTGGGTGGTTGGGTTGACTCTCAGACC

GAAAACTCTGACAACGGTACCCAGGCGGGTGGTTACATCTTCCGTAAAGAAAACG

TTATCAACGAATACGACTACTACCTGGGTATCTGCTCTGACCCGAAACTGTTCCG

TCGTACCACCATCGTTTCTGAAAACGACCGTTCTTCTTTCGAACGTCTGGACTAC

TACCAGCTGAAAACCGCGTCTGTTTACGGTAACTCTTACTGCGGTAAACACCCGT

ACACCGAAGACAAAAACGAACTGGTTAACTCTATCGACCGTTTCGTTCACCTGTC

TGGTAACAACATCCTGATCGAAAAAATCGCGAAAGACAAAGTTAAATCTAACCCG

ACCACCAACACCCCGTCTGGTTACCTGAACTTCATCCACCGTGAAGCGCCGAACA

CCTACGAATGCCTGCTGCAGGACGAAAACTTCGTTTCTCTGAACCAGCGTGTTGT

TTCTGCGCTGAAAGCGACCCTGGCGACCCTGGTTCGTGTTCCGAAAGCGCTGGTT

TACGCGAAAAAAGACTACCACCTGTTCTCTGAAATCATCAACGACATCGACGAAC

TGTCTTACGAAAAAGCGTTCTCTTACTTCCCGGTTTCTCAGACCGAATTCGAAAA

CTCTTCTAACCGTACCATCAAACCGCTGCTGCTGTTCAAAATCTCTAACAAAGAC

CTGTCTTTCGCGGAAAACTTCGAAAAAGGTAACCGTCAGAAAATCGGTAAAAAAA

ACCTGCACACCCTGTACTTCGAAGCGCTGATGAAAGGTAACCAGGACACCATCGA

CATCGGTACCGGTATGGTTTTCCACCGTGTTAAATCTCTGAACTACAACGAAAAA

ACCCTGAAATACGGTCACCACTCTACCCAGCTGAACGAAAAATTCTCTTACCCGA

TCATCAAAGACAAACGTTTCGCGTCTGACAAATTCCTGTTCCACCTGTCTACCGA

AATCAACTACAAAGAAAAACGTAAACCGCTGAACAACTCTATCATCGAATTCCTG

ACCAACAACCCGGACATCAACATCATCGGTCTGGACCGTGGTGAACGTCACCTGA

TCTACCTGACCCTGATCAACCAGAAAGGTGAAATCCTGCGTCAGAAAACCTTCAA

CATCGTTGGTAACACCAACTACCACGAAAAACTGAACCAGCGTGAAAAAGAACGT

GACAACGCGCGTAAATCTTGGGCGACCATCGGTAAAATCAAAGAACTGAAAGAAG

GTTTCCTGTCTCTGGTTATCCACGAAATCGCGAAAATCATGGTTGAAAACAACGC

GATCGTTGTTCTGGAAGACCTGAACTTCGGTTTCAAACGTGGTCGTTTCAAAGTT

GAAAAACAGATCTACCAGAAATTCGAAAAAATGCTGATCGACAAACTGAACTACC

TGGTTTTCAAAGACAAAAAAGCGAACGAAGCGGGTGGTGTTCTGAAAGGTTACCA

GCTGGCGGAAAAATTCGAATCTTTCCAGAAAATGGGTAAACAGTCTGGTTTCCTG

TTCTACGTTCCGGCGGCGTACACCTCTAAAATCGACCCGACCACCGGTTTCGTTA

ACATGCTGAACCTGAACTACACCAACATGAAAGACGCGCAGACCCTGCTGTCTGG

TATGGACAAAATCTCTTTCAACGCGGACGCGAACTACTTCGAATTCGAACTGGAC

TACGAAAAATTCAAAACCAACCAGACCGACCACACCAACAAATGGACCATCTGCA

CCGTTGGTGAAAAACGTTTCACCTACAACTCTGCGACCAAAGAAACCACCACCGT

TAACGTTACCGAAGACCTGAAAAAACTGCTGGACAAATTCGAAGTTAAATACTCT

AACGGTGACAACATCAAAGACGAAATCTGCCGTCAGACCGACGCGAAATTCTTCG

AAATCATCCTGTGGCTGCTGAAACTGACCATGCAGATGCGTAACTCTAACACCAA

AACCGAAGAAGACTTCATCCTGTCTCCGGTTAAAAACTCTAACGGTGAATTCTTC

CGTTCTAACGACGACGCGAACGGTATCTGGCCGGCGGACGCGGACGCGAACGGTG

CGTACCACATCGCGCTGAAAGGTCTGTACCTGGTTAAAGAATGCTTCAACAAAAA

CGAAAAATCTCTGAAAATCGAACACAAAAACTGGTTCAAATTCGCGCAGACCCGT

TTCAACGGTTCTCTGACCAAAAACGGTTAAGAAATCATCCTTAGCGAAAGCTAAG

GATTTTTTTTATCTGAAATGTAGGGAGACCCTCAGGTTAAATATTCACTCAGGAA

GTTATTACTCAGGAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

72
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATACCCAGTTCGAAGGT

TTCACCAACCTGTACCAGGTTTCTAAAACCCTGCGTTTCGAACTGATCCCGCAGG

GTAAAACCCTGAAACACATCCAGGAACAGGGTTTCATCGAAGAAGACAAAGCGCG

TAACGACCACTACAAAGAACTGAAACCGATCATCGACCGTATCTACAAAACCTAC

GCGGACCAGTGCCTGCAGCTGGTTCAGCTGGACTGGGAAAACCTGTCTGCGGCGA

TCGACTCTTACCGTAAAGAAAAAACCGAAGAAACCCGTAACGCGCTGATCGAAGA

ACAGGCGACCTACCGTAACGCGATCCACGACTACTTCATCGGTCGTACCGACAAC

CTGACCGACGCGATCAACAAACGTCACGCGGAAATCTACAAAGGTCTGTTCAAAG

CGGAACTGTTCAACGGTAAAGTTCTGAAACAGCTGGGTACCGTTACCACCACCGA

ACACGAAAACGCGCTGCTGCGTTCTTTCGACAAATTCACCACCTACTTCTCTGGT

TTCTACGAAAACCGTAAAAACGTTTTCTCTGCGGAAGACATCTCTACCGCGATCC

CGCACCGTATCGTTCAGGACAACTTCCCGAAATTCAAAGAAAACTGCCACATCTT

CACCCGTCTGATCACCGCGGTTCCGTCTCTGCGTGAACACTTCGAAAACGTTAAA

AAAGCGATCGGTATCTTCGTTTCTACCTCTATCGAAGAAGTTTTCTCTTTCCCGT

TCTACAACCAGCTGCTGACCCAGACCCAGATCGACCTGTACAACCAGCTGCTGGG

TGGTATCTCTCGTGAAGCGGGTACCGAAAAAATCAAAGGTCTGAACGAAGTTCTG

AACCTGGCGATCCAGAAAAACGACGAAACCGCGCACATCATCGCGTCTCTGCCGC

ACCGTTTCATCCCGCTGTTCAAACAGATCCTGTCTGACCGTAACACCCTGTCTTT

CATCCTGGAAGAATTCAAATCTGACGAAGAAGTTATCCAGTCTTTCTGCAAATAC

AAAACCCTGCTGCGTAACGAAAACGTTCTGGAAACCGCGGAAGCGCTGTTCAACG

AACTGAACTCTATCGACCTGACCCACATCTTCATCTCTCACAAAAAACTGGAAAC

CATCTCTTCTGCGCTGTGCGACCACTGGGACACCCTGCGTAACGCGCTGTACGAA

CGTCGTATCTCTGAACTGACCGGTAAAATCACCAAATCTGCGAAAGAAAAAGTTC

AGCGTTCTCTGAAACACGAAGACATCAACCTGCAGGAAATCATCTCTGCGGCGGG

TAAAGAACTGTCTGAAGCGTTCAAACAGAAAACCTCTGAAATCCTGTCTCACGCG

CACGCGGCGCTGGACCAGCCGCTGCCGACCACCCTGAAAAAACAGGAAGAAAAAG

AAATCCTGAAATCTCAGCTGGACTCTCTGCTGGGTCTGTACCACCTGCTGGACTG

GTTCGCGGTTGACGAATCTAACGAAGTTGACCCGGAATTCTCTGCGCGTCTGACC

GGTATCAAACTGGAAATGGAACCGTCTCTGTCTTTCTACAACAAAGCGCGTAACT

ACGCGACCAAAAAACCGTACTCTGTTGAAAAATTCAAACTGAACTTCCAGATGCC

GACCCTGGCGTCTGGTTGGGACGTTAACAAAGAAAAAAACAACGGTGCGATCCTG

TTCGTTAAAAACGGTCTGTACTACCTGGGTATCATGCCGAAACAGAAAGGTCGTT

ACAAAGCGCTGTCTTTCGAACCGACCGAAAAAACCTCTGAAGGTTTCGACAAAAT

GTACTACGACTACTTCCCGGACGCGGCGAAAATGATCCCGAAATGCTCTACCCAG

CTGAAAGCGGTTACCGCGCACTTCCAGACCCACACCACCCCGATCCTGCTGTCTA

ACAACTTCATCGAACCGCTGGAAATCACCAAAGAAATCTACGACCTGAACAACCC

GGAAAAAGAACCGAAAAAATTCCAGACCGCGTACGCGAAAAAAACCGGTGACCAG

AAAGGTTACCGTGAAGCGCTGTGCAAATGGATCGACTTCACCCGTGACTTCCTGT

CTAAATACACCAAAACCACCTCTATCGACCTGTCTTCTCTGCGTCCGTCTTCTCA

GTACAAAGACCTGGGTGAATACTACGCGGAACTGAACCCGCTGCTGTACCACATC

TCTTTCCAGCGTATCGCGGAAAAAGAAATCATGGACGCGGTTGAAACCGGTAAAC

TGTACCTGTTCCAGATCTACAACAAAGACTTCGCGAAAGGTCACCACGGTAAACC

GAACCTGCACACCCTGTACTGGACCGGTCTGTTCTCTCCGGAAAACCTGGCGAAA

ACCTCTATCAAACTGAACGGTCAGGCGGAACTGTTCTACCGTCCGAAATCTCGTA

TGAAACGTATGGCGCACCGTCTGGGTGAAAAAATGCTGAACAAAAAACTGAAAGA

CCAGAAAACCCCGATCCCGGACACCCTGTACCAGGAACTGTACGACTACGTTAAC

CACCGTCTGTCTCACGACCTGTCTGACGAAGCGCGTGCGCTGCTGCCGAACGTTA

TCACCAAAGAAGTTTCTCACGAAATCATCAAAGACCGTCGTTTCACCTCTGACAA

ATTCTTCTTCCACGTTCCGATCACCCTGAACTACCAGGCGGCGAACTCTCCGTCT

AAATTCAACCAGCGTGTTAACGCGTACCTGAAAGAACACCCGGAAACCCCGATCA

TCGGTATCGACCGTGGTGAACGTAACCTGATCTACATCACCGTTATCGACTCTAC

CGGTAAAATCCTGGAACAGCGTTCTCTGAACACCATCCAGCAGTTCGACTACCAG

AAAAAACTGGACAACCGTGAAAAAGAACGTGTTGCGGCGCGTCAGGCGTGGTCTG

TTGTTGGTACCATCAAAGACCTGAAACAGGGTTACCTGTCTCAGGTTATCCACGA

AATCGTTGACCTGATGATCCACTACCAGGCGGTTGTTGTTCTGGAAAACCTGAAC

TTCGGTTTCAAATCTAAACGTACCGGTATCGCGGAAAAAGCGGTTTACCAGCAGT

TCGAAAAAATGCTGATCGACAAACTGAACTGCCTGGTTCTGAAAGACTACCCGGC

GGAAAAAGTTGGTGGTGTTCTGAACCCGTACCAGCTGACCGACCAGTTCACCTCT

TTCGCGAAAATGGGTACCCAGTCTGGTTTCCTGTTCTACGTTCCGGCGCCGTACA

CCTCTAAAATCGACCCGCTGACCGGTTTCGTTGACCCGTTCGTTTGGAAAACCAT

CAAAAACCACGAATCTCGTAAACACTTCCTGGAAGGTTTCGACTTCCTGCACTAC

GACGTTAAAACCGGTGACTTCATCCTGCACTTCAAAATGAACCGTAACCTGTCTT

TCCAGCGTGGTCTGCCGGGTTTCATGCCGGCGTGGGACATCGTTTTCGAAAAAAA

CGAAACCCAGTTCGACGCGAAAGGTACCCCGTTCATCGCGGGTAAACGTATCGTT

CCGGTTATCGAAAACCACCGTTTCACCGGTCGTTACCGTGACCTGTACCCGGCGA

ACGAACTGATCGCGCTGCTGGAAGAAAAAGGTATCGTTTTCCGTGACGGTTCTAA

CATCCTGCCGAAACTGCTGGAAAACGACGACTCTCACGCGATCGACACCATGGTT

GCGCTGATCCGTTCTGTTCTGCAGATGCGTAACTCTAACGCGGCGACCGGTGAAG

ACTACATCAACTCTCCGGTTCGTGACCTGAACGGTGTTTGCTTCGACTCTCGTTT

CCAGAACCCGGAATGGCCGATGGACGCGGACGCGAACGGTGCGTACCACATCGCG

CTGAAAGGTCAGCTGCTGCTGAACCACCTGAAAGAATCTAAAGACCTGAAACTGC

AGAACGGTATCTCTAACCAGGACTGGCTGGCGTACATCCAGGAACTGCGTAACTA

GAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATGTAGGGAGACC

CTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

73
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATGCGGTTAAATCTATC

AAAGTTAAACTGCGTCTGGACGACATGCCGGAAATCCGTGCGGGTCTGTGGAAAC

TGCACAAAGAAGTTAACGCGGGTGTTCGTTACTACACCGAATGGCTGTCTCTGCT

GCGTCAGGAAAACCTGTACCGTCGTTCTCCGAACGGTGACGGTGAACAGGAATGC

GACAAAACCGCGGAAGAATGCAAAGCGGAACTGCTGGAACGTCTGCGTGCGCGTC

AGGTTGAAAACGGTCACCGTGGTCCGGCGGGTTCTGACGACGAACTGCTGCAGCT

GGCGCGTCAGCTGTACGAACTGCTGGTTCCGCAGGCGATCGGTGCGAAAGGTGAC

GCGCAGCAGATCGCGCGTAAATTCCTGTCTCCGCTGGCGGACAAAGACGCGGTTG

GTGGTCTGGGTATCGCGAAAGCGGGTAACAAACCGCGTTGGGTTCGTATGCGTGA

AGCGGGTGAACCGGGTTGGGAAGAAGAAAAAGAAAAAGCGGAAACCCGTAAATCT

GCGGACCGTACCGCGGACGTTCTGCGTGCGCTGGCGGACTTCGGTCTGAAACCGC

TGATGCGTGTTTACACCGACTCTGAAATGTCTTCTGTTGAATGGAAACCGCTGCG

TAAAGGTCAGGCGGTTCGTACCTGGGACCGTGACATGTTCCAGCAGGCGATCGAA

CGTATGATGTCTTGGGAATCTTGGAACCAGCGTGTTGGTCAGGAATACGCGAAAC

TGGTTGAACAGAAAAACCGTTTCGAACAGAAAAACTTCGTTGGTCAGGAACACCT

GGTTCACCTGGTTAACCAGCTGCAGCAGGACATGAAAGAAGCGTCTCCGGGTCTG

GAATCTAAAGAACAGACCGCGCACTACGTTACCGGTCGTGCGCTGCGTGGTTCTG

ACAAAGTTTTCGAAAAATGGGGTAAACTGGCGCCGGACGCGCCGTTCGACCTGTA

CGACGCGGAAATCAAAAACGTTCAGCGTCGTAACACCCGTCGTTTCGGTTCTCAC

GACCTGTTCGCGAAACTGGCGGAACCGGAATACCAGGCGCTGTGGCGTGAAGACG

CGTCTTTCCTGACCCGTTACGCGGTTTACAACTCTATCCTGCGTAAACTGAACCA

CGCGAAAATGTTCGCGACCTTCACCCTGCCGGACGCGACCGCGCACCCGATCTGG

ACCCGTTTCGACAAACTGGGTGGTAACCTGCACCAGTACACCTTCCTGTTCAACG

AATTCGGTGAACGTCGTCACGCGATCCGTTTCCACAAACTGCTGAAAGTTGAAAA

CGGTGTTGCGCGTGAAGTTGACGACGTTACCGTTCCGATCTCTATGTCTGAACAG

CTGGACAACCTGCTGCCGCGTGACCCGAACGAACCGATCGCGCTGTACTTCCGTG

ACTACGGTGCGGAACAGCACTTCACCGGTGAATTCGGTGGTGCGAAAATCCAGTG

CCGTCGTGACCAGCTGGCGCACATGCACCGTCGTCGTGGTGCGCGTGACGTTTAC

CTGAACGTTTCTGTTCGTGTTCAGTCTCAGTCTGAAGCGCGTGGTGAACGTCGTC

CGCCGTACGCGGCGGTTTTCCGTCTGGTTGGTGACAACCACCGTGCGTTCGTTCA

CTTCGACAAACTGTCTGACTACCTGGCGGAACACCCGGACGACGGTAAACTGGGT

TCTGAAGGTCTGCTGTCTGGTCTGCGTGTTATGTCTGTTGACCTGGGTCTGCGTA

CCTCTGCGTCTATCTCTGTTTTCCGTGTTGCGCGTAAAGACGAACTGAAACCGAA

CTCTAAAGGTCGTGTTCCGTTCTTCTTCCCGATCAAAGGTAACGACAACCTGGTT

GCGGTTCACGAACGTTCTCAGCTGCTGAAACTGCCGGGTGAAACCGAATCTAAAG

ACCTGCGTGCGATCCGTGAAGAACGTCAGCGTACCCTGCGTCAGCTGCGTACCCA

GCTGGCGTACCTGCGTCTGCTGGTTCGTTGCGGTTCTGAAGACGTTGGTCGTCGT

GAACGTTCTTGGGCGAAACTGATCGAACAGCCGGTTGACGCGGCGAACCACATGA

CCCCGGACTGGCGTGAAGCGTTCGAAAACGAACTGCAGAAACTGAAATCTCTGCA

CGGTATCTGCTCTGACAAAGAATGGATGGACGCGGTTTACGAATCTGTTCGTCGT

GTTTGGCGTCACATGGGTAAACAGGTTCGTGACTGGCGTAAAGACGTTCGTTCTG

GTGAACGTCCGAAAATCCGTGGTTACGCGAAAGACGTTGTTGGTGGTAACTCTAT

CGAACAGATCGAATACCTGGAACGTCAGTACAAATTCCTGAAATCTTGGTCTTTC

TTCGGTAAAGTTTCTGGTCAGGTTATCCGTGCGGAAAAAGGTTCTCGTTTCGCGA

TCACCCTGCGTGAACACATCGACCACGCGAAAGAAGACCGTCTGAAAAAACTGGC

GGACCGTATCATCATGGAAGCGCTGGGTTACGTTTACGCGCTGGACGAACGTGGT

AAAGGTAAATGGGTTGCGAAATACCCGCCGTGCCAGCTGATCCTGCTGGAAGAAC

TGTCTGAATACCAGTTCAACAACGACCGTCCGCCGTCTGAAAACAACCAGCTGAT

GCAGTGGTCTCACCGTGGTGTTTTCCAGGAACTGATCAACCAGGCGCAGGTTCAC

GACCTGCTGGTTGGTACCATGTACGCGGCGTTCTCTTCTCGTTTCGACGCGCGTA

CCGGTGCGCCGGGTATCCGTTGCCGTCGTGTTCCGGCGCGTTGCACCCAGGAACA

CAACCCGGAACCGTTCCCGTGGTGGCTGAACAAATTCGTTGTTGAACACACCCTG

GACGCGTGCCCGCTGCGTGCGGACGACCTGATCCCGACCGGTGAAGGTGAAATCT

TCGTTTCTCCGTTCTCTGCGGAAGAAGGTGACTTCCACCAGATCCACGCGGACCT

GAACGCGGCGCAGAACCTGCAGCAGCGTCTGTGGTCTGACTTCGACATCTCTCAG

ATCCGTCTGCGTTGCGACTGGGGTGAAGTTGACGGTGAACTGGTTCTGATCCCGC

GTCTGACCGGTAAACGTACCGCGGACTCTTACTCTAACAAAGTTTTCTACACCAA

CACCGGTGTTACCTACTACGAACGTGAACGTGGTAAAAAACGTCGTAAAGTTTTC

GCGCAGGAAAAACTGTCTGAAGAAGAAGCGGAACTGCTGGTTGAAGCGGACGAAG

CGCGTGAAAAATCTGTTGTTCTGATGCGTGACCCGTCTGGTATCATCAACCGTGG

TAACTGGACCCGTCAGAAAGAATTCTGGTCTATGGTTAACCAGCGTATCGAAGGT

TACCTGGTTAAACAGATCCGTTCTCGTGTTCCGCTGCAGGACTCTGCGTGCGAAA

ACACCGGTGACATCTAAGAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTATC

TGAAATGTAGGGAGACCCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGG

AAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

74
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATGCGACCCGTTCTTTC

ATCCTGAAAATCGAACCGAACGAAGAAGTTAAAAAAGGTCTGTGGAAAACCCACG

AAGTTCTGAACCACGGTATCGCGTACTACATGAACATCCTGAAACTGATCCGTCA

GGAAGCGATCTACGAACACCACGAACAGGACCCGAAAAACCCGAAAAAAGTTTCT

AAAGCGGAAATCCAGGCGGAACTGTGGGACTTCGTTCTGAAAATGCAGAAATGCA

ACTCTTTCACCCACGAAGTTGACAAAGACGTTGTTTTCAACATCCTGCGTGAACT

GTACGAAGAACTGGTTCCGTCTTCTGTTGAAAAAAAAGGTGAAGCGAACCAGCTG

TCTAACAAATTCCTGTACCCGCTGGTTGACCCGAACTCTCAGTCTGGTAAAGGTA

CCGCGTCTTCTGGTCGTAAACCGCGTTGGTACAACCTGAAAATCGCGGGTGACCC

GTCTTGGGAAGAAGAAAAAAAAAAATGGGAAGAAGACAAAAAAAAAGACCCGCTG

GCGAAAATCCTGGGTAAACTGGCGGAATACGGTCTGATCCCGCTGTTCATCCCGT

TCACCGACTCTAACGAACCGATCGTTAAAGAAATCAAATGGATGGAAAAATCTCG

TAACCAGTCTGTTCGTCGTCTGGACAAAGACATGTTCATCCAGGCGCTGGAACGT

TTCCTGTCTTGGGAATCTTGGAACCTGAAAGTTAAAGAAGAATACGAAAAAGTTG

AAAAAGAACACAAAACCCTGGAAGAACGTATCAAAGAAGACATCCAGGCGTTCAA

ATCTCTGGAACAGTACGAAAAAGAACGTCAGGAACAGCTGCTGCGTGACACCCTG

AACACCAACGAATACCGTCTGTCTAAACGTGGTCTGCGTGGTTGGCGTGAAATCA

TCCAGAAATGGCTGAAAATGGACGAAAACGAACCGTCTGAAAAATACCTGGAAGT

TTTCAAAGACTACCAGCGTAAACACCCGCGTGAAGCGGGTGACTACTCTGTTTAC

GAATTCCTGTCTAAAAAAGAAAACCACTTCATCTGGCGTAACCACCCGGAATACC

CGTACCTGTACGCGACCTTCTGCGAAATCGACAAAAAAAAAAAAGACGCGAAACA

GCAGGCGACCTTCACCCTGGCGGACCCGATCAACCACCCGCTGTGGGTTCGTTTC

GAAGAACGTTCTGGTTCTAACCTGAACAAATACCGTATCCTGACCGAACAGCTGC

ACACCGAAAAACTGAAAAAAAAACTGACCGTTCAGCTGGACCGTCTGATCTACCC

GACCGAATCTGGTGGTTGGGAAGAAAAAGGTAAAGTTGACATCGTTCTGCTGCCG

TCTCGTCAGTTCTACAACCAGATCTTCCTGGACATCGAAGAAAAAGGTAAACACG

CGTTCACCTACAAAGACGAATCTATCAAATTCCCGCTGAAAGGTACCCTGGGTGG

TGCGCGTGTTCAGTTCGACCGTGACCACCTGCGTCGTTACCCGCACAAAGTTGAA

TCTGGTAACGTTGGTCGTATCTACTTCAACATGACCGTTAACATCGAACCGACCG

AATCTCCGGTTTCTAAATCTCTGAAAATCCACCGTGACGACTTCCCGAAATTCGT

TAACTTCAAACCGAAAGAACTGACCGAATGGATCAAAGACTCTAAAGGTAAAAAA

CTGAAATCTGGTATCGAATCTCTGGAAATCGGTCTGCGTGTTATGTCTATCGACC

TGGGTCAGCGTCAGGCGGCGGCGGCGTCTATCTTCGAAGTTGTTGACCAGAAACC

GGACATCGAAGGTAAACTGTTCTTCCCGATCAAAGGTACCGAACTGTACGCGGTT

CACCGTGCGTCTTTCAACATCAAACTGCCGGGTGAAACCCTGGTTAAATCTCGTG

AAGTTCTGCGTAAAGCGCGTGAAGACAACCTGAAACTGATGAACCAGAAACTGAA

CTTCCTGCGTAACGTTCTGCACTTCCAGCAGTTCGAAGACATCACCGAACGTGAA

AAACGTGTTACCAAATGGATCTCTCGTCAGGAAAACTCTGACGTTCCGCTGGTTT

ACCAGGACGAACTGATCCAGATCCGTGAACTGATGTACAAACCGTACAAAGACTG

GGTTGCGTTCCTGAAACAGCTGCACAAACGTCTGGAAGTTGAAATCGGTAAAGAA

GTTAAACACTGGCGTAAATCTCTGTCTGACGGTCGTAAAGGTCTGTACGGTATCT

CTCTGAAAAACATCGACGAAATCGACCGTACCCGTAAATTCCTGCTGCGTTGGTC

TCTGCGTCCGACCGAACCGGGTGAAGTTCGTCGTCTGGAACCGGGTCAGCGTTTC

GCGATCGACCAGCTGAACCACCTGAACGCGCTGAAAGAAGACCGTCTGAAAAAAA

TGGCGAACACCATCATCATGCACGCGCTGGGTTACTGCTACGACGTTCGTAAAAA

AAAATGGCAGGCGAAAAACCCGGCGTGCCAGATCATCCTGTTCGAAGACCTGTCT

AACTACAACCCGTACGAAGAACGTTCTCGTTTCGAAAACTCTAAACTGATGAAAT

GGTCTCGTCGTGAAATCCCGCGTCAGGTTGCGCTGCAGGGTGAAATCTACGGTCT

GCAGGTTGGTGAAGTTGGTGCGCAGTTCTCTTCTCGTTTCCACGCGAAAACCGGT

TCTCCGGGTATCCGTTGCTCTGTTGTTACCAAAGAAAAACTGCAGGACAACCGTT

TCTTCAAAAACCTGCAGCGTGAAGGTCGTCTGACCCTGGACAAAATCGCGGTTCT

GAAAGAAGGTGACCTGTACCCGGACAAAGGTGGTGAAAAATTCATCTCTCTGTCT

AAAGACCGTAAACTGGTTACCACCCACGCGGACATCAACGCGGCGCAGAACCTGC

AGAAACGTTTCTGGACCCGTACCCACGGTTTCTACAAAGTTTACTGCAAAGCGTA

CCAGGTTGACGGTCAGACCGTTTACATCCCGGAATCTAAAGACCAGAAACAGAAA

ATCATCGAAGAATTCGGTGAAGGTTACTTCATCCTGAAAGACGGTGTTTACGAAT

GGGGTAACGCGGGTAAACTGAAAATCAAAAAAGGTTCTTCTAAACAGTCTTCTTC

TGAACTGGTTGACTCTGACATCCTGAAAGACTCTTTCGACCTGGCGTCTGAACTG

AAAGGTGAAAAACTGATGCTGTACCGTGACCCGTCTGGTAACGTTTTCCCGTCTG

ACAAATGGATGGCGGCGGGTGTTTTCTTCGGTAAACTGGAACGTATCCTGATCTC

TAAACTGACCAACCAGTACTCTATCTCTACCATCGAAGACGACTCTTCTAAACAG

TCTATGTAAGAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATGT

AGGGAGACCCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGGAAGCAAAG

AGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

75
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATCCGACCCGTACCATC

AACCTGAAACTGGTTCTGGGTAAAAACCCGGAAAACGCGACCCTGCGTCGTGCGC

TGTTCTCTACCCACCGTCTGGTTAACCAGGCGACCAAACGTATCGAAGAATTCCT

GCTGCTGTGCCGTGGTGAAGCGTACCGTACCGTTGACAACGAAGGTAAAGAAGCG

GAAATCCCGCGTCACGCGGTTCAGGAAGAAGCGCTGGCGTTCGCGAAAGCGGCGC

AGCGTCACAACGGTTGCATCTCTACCTACGAAGACCAGGAAATCCTGGACGTTCT

GCGTCAGCTGTACGAACGTCTGGTTCCGTCTGTTAACGAAAACAACGAAGCGGGT

GACGCGCAGGCGGCGAACGCGTGGGTTTCTCCGCTGATGTCTGCGGAATCTGAAG

GTGGTCTGTCTGTTTACGACAAAGTTCTGGACCCGCCGCCGGTTTGGATGAAACT

GAAAGAAGAAAAAGCGCCGGGTTGGGAAGCGGCGTCTCAGATCTGGATCCAGTCT

GACGAAGGTCAGTCTCTGCTGAACAAACCGGGTTCTCCGCCGCGTTGGATCCGTA

AACTGCGTTCTGGTCAGCCGTGGCAGGACGACTTCGTTTCTGACCAGAAAAAAAA

ACAGGACGAACTGACCAAAGGTAACGCGCCGCTGATCAAACAGCTGAAAGAAATG

GGTCTGCTGCCGCTGGTTAACCCGTTCTTCCGTCACCTGCTGGACCCGGAAGGTA

AAGGTGTTTCTCCGTGGGACCGTCTGGCGGTTCGTGCGGCGGTTGCGCACTTCAT

CTCTTGGGAATCTTGGAACCACCGTACCCGTGCGGAATACAACTCTCTGAAACTG

CGTCGTGACGAATTCGAAGCGGCGTCTGACGAATTCAAAGACGACTTCACCCTGC

TGCGTCAGTACGAAGCGAAACGTCACTCTACCCTGAAATCTATCGCGCTGGCGGA

CGACTCTAACCCGTACCGTATCGGTGTTCGTTCTCTGCGTGCGTGGAACCGTGTT

CGTGAAGAATGGATCGACAAAGGTGCGACCGAAGAACAGCGTGTTACCATCCTGT

CTAAACTGCAGACCCAGCTGCGTGGTAAATTCGGTGACCCGGACCTGTTCAACTG

GCTGGCGCAGGACCGTCACGTTCACCTGTGGTCTCCGCGTGACTCTGTTACCCCG

CTGGTTCGTATCAACGCGGTTGACAAAGTTCTGCGTCGTCGTAAACCGTACGCGC

TGATGACCTTCGCGCACCCGCGTTTCCACCCGCGTTGGATCCTGTACGAAGCGCC

GGGTGGTTCTAACCTGCGTCAGTACGCGCTGGACTGCACCGAAAACGCGCTGCAC

ATCACCCTGCCGCTGCTGGTTGACGACGCGCACGGTACCTGGATCGAAAAAAAAA

TCCGTGTTCCGCTGGCGCCGTCTGGTCAGATCCAGGACCTGACCCTGGAAAAACT

GGAAAAAAAAAAAAACCGTCTGTACTACCGTTCTGGTTTCCAGCAGTTCGCGGGT

CTGGCGGGTGGTGCGGAAGTTCTGTTCCACCGTCCGTACATGGAACACGACGAAC

GTTCTGAAGAATCTCTGCTGGAACGTCCGGGTGCGGTTTGGTTCAAACTGACCCT

GGACGTTGCGACCCAGGCGCCGCCGAACTGGCTGGACGGTAAAGGTCGTGTTCGT

ACCCCGCCGGAAGTTCACCACTTCAAAACCGCGCTGTCTAACAAATCTAAACACA

CCCGTACCCTGCAGCCGGGTCTGCGTGTTCTGTCTGTTGACCTGGGTATGCGTAC

CTTCGCGTCTTGCTCTGTTTTCGAACTGATCGAAGGTAAACCGGAAACCGGTCGT

GCGTTCCCGGTTGCGGACGAACGTTCTATGGACTCTCCGAACAAACTGTGGGCGA

AACACGAACGTTCTTTCAAACTGACCCTGCCGGGTGAAACCCCGTCTCGTAAAGA

AGAAGAAGAACGTTCTATCGCGCGTGCGGAAATCTACGCGCTGAAACGTGACATC

CAGCGTCTGAAATCTCTGCTGCGTCTGGGTGAAGAAGACAACGACAACCGTCGTG

ACGCGCTGCTGGAACAGTTCTTCAAAGGTTGGGGTGAAGAAGACGTTGTTCCGGG

TCAGGCGTTCCCGCGTTCTCTGTTCCAGGGTCTGGGTGCGGCGCCGTTCCGTTCT

ACCCCGGAACTGTGGCGTCAGCACTGCCAGACCTACTACGACAAAGCGGAAGCGT

GCCTGGCGAAACACATCTCTGACTGGCGTAAACGTACCCGTCCGCGTCCGACCTC

TCGTGAAATGTGGTACAAAACCCGTTCTTACCACGGTGGTAAATCTATCTGGATG

CTGGAATACCTGGACGCGGTTCGTAAACTGCTGCTGTCTTGGTCTCTGCGTGGTC

GTACCTACGGTGCGATCAACCGTCAGGACACCGCGCGTTTCGGTTCTCTGGCGTC

TCGTCTGCTGCACCACATCAACTCTCTGAAAGAAGACCGTATCAAAACCGGTGCG

GACTCTATCGTTCAGGCGGCGCGTGGTTACATCCCGCTGCCGCACGGTAAAGGTT

GGGAACAGCGTTACGAACCGTGCCAGCTGATCCTGTTCGAAGACCTGGCGCGTTA

CCGTTTCCGTGTTGACCGTCCGCGTCGTGAAAACTCTCAGCTGATGCAGTGGAAC

CACCGTGCGATCGTTGCGGAAACCACCATGCAGGCGGAACTGTACGGTCAGATCG

TTGAAAACACCGCGGCGGGTTTCTCTTCTCGTTTCCACGCGGCGACCGGTGCGCC

GGGTGTTCGTTGCCGTTTCCTGCTGGAACGTGACTTCGACAACGACCTGCCGAAA

CCGTACCTGCTGCGTGAACTGTCTTGGATGCTGGGTAACACCAAAGTTGAATCTG

AAGAAGAAAAACTGCGTCTGCTGTCTGAAAAAATCCGTCCGGGTTCTCTGGTTCC

GTGGGACGGTGGTGAACAGTTCGCGACCCTGCACCCGAAACGTCAGACCCTGTGC

GTTATCCACGCGGACATGAACGCGGCGCAGAACCTGCAGCGTCGTTTCTTCGGTC

GTTGCGGTGAAGCGTTCCGTCTGGTTTGCCAGCCGCACGGTGACGACGTTCTGCG

TCTGGCGTCTACCCCGGGTGCGCGTCTGCTGGGTGCGCTGCAGCAGCTGGAAAAC

GGTCAGGGTGCGTTCGAACTGGTTCGTGACATGGGTTCTACCTCTCAGATGAACC

GTTTCGTTATGAAATCTCTGGGTAAAAAAAAAATCAAACCGCTGCAGGACAACAA

CGGTGACGACGAACTGGAAGACGTTCTGTCTGTTCTGCCGGAAGAAGACGACACC

GGTCGTATCACCGTTTTCCGTGACTCTTCTGGTATCTTCTTCCCGTGCAACGTTT

GGATCCCGGCGAAACAGTTCTGGCCGGCGGTTCGTGCGATGATCTGGAAAGTTAT

GGCGTCTCACTCTCTGGGTTAAGAAATCATCCTTAGCGAAAGCTAAGGATTTTTT

TTATCTGAAATGTAGGGAGACCCTCAGGTTAAATATTCACTCAGGAAGTTATTAC

TCAGGAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

76
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATACCAAACTGCGTCAC

CGTCAGAAAAAACTGACCCACGACTGGGCGGGTTCTAAAAAACGTGAAGTTCTGG

GTTCTAACGGTAAACTGCAGAACCCGCTGCTGATGCCGGTTAAAAAAGGTCAGGT

TACCGAATTCCGTAAAGCGTTCTCTGCGTACGCGCGTGCGACCAAAGGTGAAATG

ACCGACGGTCGTAAAAACATGTTCACCCACTCTTTCGAACCGTTCAAAACCAAAC

CGTCTCTGCACCAGTGCGAACTGGCGGACAAAGCGTACCAGTCTCTGCACTCTTA

CCTGCCGGGTTCTCTGGCGCACTTCCTGCTGTCTGCGCACGCGCTGGGTTTCCGT

ATCTTCTCTAAATCTGGTGAAGCGACCGCGTTCCAGGCGTCTTCTAAAATCGAAG

CGTACGAATCTAAACTGGCGTCTGAACTGGCGTGCGTTGACCTGTCTATCCAGAA

CCTGACCATCTCTACCCTGTTCAACGCGCTGACCACCTCTGTTCGTGGTAAAGGT

GAAGAAACCTCTGCGGACCCGCTGATCGCGCGTTTCTACACCCTGCTGACCGGTA

AACCGCTGTCTCGTGACACCCAGGGTCCGGAACGTGACCTGGCGGAAGTTATCTC

TCGTAAAATCGCGTCTTCTTTCGGTACCTGGAAAGAAATGACCGCGAACCCGCTG

CAGTCTCTGCAGTTCTTCGAAGAAGAACTGCACGCGCTGGACGCGAACGTTTCTC

TGTCTCCGGCGTTCGACGTTCTGATCAAAATGAACGACCTGCAGGGTGACCTGAA

AAACCGTACCATCGTTTTCGACCCGGACGCGCCGGTTTTCGAATACAACGCGGAA

GACCCGGCGGACATCATCATCAAACTGACCGCGCGTTACGCGAAAGAAGCGGTTA

TCAAAAACCAGAACGTTGGTAACTACGTTAAAAACGCGATCACCACCACCAACGC

GAACGGTCTGGGTTGGCTGCTGAACAAAGGTCTGTCTCTGCTGCCGGTTTCTACC

GACGACGAACTGCTGGAATTCATCGGTGTTGAACGTTCTCACCCGTCTTGCCACG

CGCTGATCGAACTGATCGCGCAGCTGGAAGCGCCGGAACTGTTCGAAAAAAACGT

TTTCTCTGACACCCGTTCTGAAGTTCAGGGTATGATCGACTCTGCGGTTTCTAAC

CACATCGCGCGTCTGTCTTCTTCTCGTAACTCTCTGTCTATGGACTCTGAAGAAC

TGGAACGTCTGATCAAATCTTTCCAGATCCACACCCCGCACTGCTCTCTGTTCAT

CGGTGCGCAGTCTCTGTCTCAGCAGCTGGAATCTCTGCCGGAAGCGCTGCAGTCT

GGTGTTAACTCTGCGGACATCCTGCTGGGTTCTACCCAGTACATGCTGACCAACT

CTCTGGTTGAAGAATCTATCGCGACCTACCAGCGTACCCTGAACCGTATCAACTA

CCTGTCTGGTGTTGCGGGTCAGATCAACGGTGCGATCAAACGTAAAGCGATCGAC

GGTGAAAAAATCCACCTGCCGGCGGCGTGGTCTGAACTGATCTCTCTGCCGTTCA

TCGGTCAGCCGGTTATCGACGTTGAATCTGACCTGGCGCACCTGAAAAACCAGTA

CCAGACCCTGTCTAACGAATTCGACACCCTGATCTCTGCGCTGCAGAAAAACTTC

GACCTGAACTTCAACAAAGCGCTGCTGAACCGTACCCAGCACTTCGAAGCGATGT

GCCGTTCTACCAAAAAAAACGCGCTGTCTAAACCGGAAATCGTTTCTTACCGTGA

CCTGCTGGCGCGTCTGACCTCTTGCCTGTACCGTGGTTCTCTGGTTCTGCGTCGT

GCGGGTATCGAAGTTCTGAAAAAACACAAAATCTTCGAATCTAACTCTGAACTGC

GTGAACACGTTCACGAACGTAAACACTTCGTTTTCGTTTCTCCGCTGGACCGTAA

AGCGAAAAAACTGCTGCGTCTGACCGACTCTCGTCCGGACCTGCTGCACGTTATC

GACGAAATCCTGCAGCACGACAACCTGGAAAACAAAGACCGTGAATCTCTGTGGC

TGGTTCGTTCTGGTTACCTGCTGGCGGGTCTGCCGGACCAGCTGTCTTCTTCTTT

CATCAACCTGCCGATCATCACCCAGAAAGGTGACCGTCGTCTGATCGACCTGATC

CAGTACGACCAGATCAACCGTGACGCGTTCGTTATGCTGGTTACCTCTGCGTTCA

AATCTAACCTGTCTGGTCTGCAGTACCGTGCGAACAAACAGTCTTTCGTTGTTAC

CCGTACCCTGTCTCCGTACCTGGGTTCTAAACTGGTTTACGTTCCGAAAGACAAA

GACTGGCTGGTTCCGTCTCAGATGTTCGAAGGTCGTTTCGCGGACATCCTGCAGT

CTGACTACATGGTTTGGAAAGACGCGGGTCGTCTGTGCGTTATCGACACCGCGAA

ACACCTGTCTAACATCAAAAAATCTGTTTTCTCTTCTGAAGAAGTTCTGGCGTTC

CTGCGTGAACTGCCGCACCGTACCTTCATCCAGACCGAAGTTCGTGGTCTGGGTG

TTAACGTTGACGGTATCGCGTTCAACAACGGTGACATCCCGTCTCTGAAAACCTT

CTCTAACTGCGTTCAGGTTAAAGTTTCTCGTACCAACACCTCTCTGGTTCAGACC

CTGAACCGTTGGTTCGAAGGTGGTAAAGTTTCTCCGCCGTCTATCCAGTTCGAAC

GTGCGTACTACAAAAAAGACGACCAGATCCACGAAGACGCGGCGAAACGTAAAAT

CCGTTTCCAGATGCCGGCGACCGAACTGGTTCACGCGTCTGACGACGCGGGTTGG

ACCCCGTCTTACCTGCTGGGTATCGACCCGGGTGAATACGGTATGGGTCTGTCTC

TGGTTTCTATCAACAACGGTGAAGTTCTGGACTCTGGTTTCATCCACATCAACTC

TCTGATCAACTTCGCGTCTAAAAAATCTAACCACCAGACCAAAGTTGTTCCGCGT

CAGCAGTACAAATCTCCGTACGCGAACTACCTGGAACAGTCTAAAGACTCTGCGG

CGGGTGACATCGCGCACATCCTGGACCGTCTGATCTACAAACTGAACGCGCTGCC

GGTTTTCGAAGCGCTGTCTGGTAACTCTCAGTCTGCGGCGGACCAGGTTTGGACC

AAAGTTCTGTCTTTCTACACCTGGGGTGACAACGACGCGCAGAACTCTATCCGTA

AACAGCACTGGTTCGGTGCGTCTCACTGGGACATCAAAGGTATGCTGCGTCAGCC

GCCGACCGAAAAAAAACCGAAACCGTACATCGCGTTCCCGGGTTCTCAGGTTTCT

TCTTACGGTAACTCTCAGCGTTGCTCTTGCTGCGGTCGTAACCCGATCGAACAGC

TGCGTGAAATGGCGAAAGACACCTCTATCAAAGAACTGAAAATCCGTAACTCTGA

AATCCAGCTGTTCGACGGTACCATCAAACTGTTCAACCCGGACCCGTCTACCGTT

ATCGAACGTCGTCGTCACAACCTGGGTCCGTCTCGTATCCCGGTTGCGGACCGTA

CCTTCAAAAACATCTCTCCGTCTTCTCTGGAATTCAAAGAACTGATCACCATCGT

TTCTCGTTCTATCCGTCACTCTCCGGAATTCATCGCGAAAAAACGTGGTATCGGT

TCTGAATACTTCTGCGCGTACTCTGACTGCAACTCTTCTCTGAACTCTGAAGCGA

ACGCGGCGGCGAACGTTGCGCAGAAATTCCAGAAACAGCTGTTCTTCGAACTGTA

AGAAATCATCCTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATGTAGGGAGAC

CCTCAGGTTAAATATTCACTCAGGAAGTTATTACTCAGGAAGCAAAGAGGATTAC

A

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

77
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATAAACGTATCCTGAAC

TCTCTGAAAGTTGCGGCGCTGCGTCTGCTGTTCCGTGGTAAAGGTTCTGAACTGG

TTAAAACCGTTAAATACCCGCTGGTTTCTCCGGTTCAGGGTGCGGTTGAAGAACT

GGCGGAAGCGATCCGTCACGACAACCTGCACCTGTTCGGTCAGAAAGAAATCGTT

GACCTGATGGAAAAAGACGAAGGTACCCAGGTTTACTCTGTTGTTGACTTCTGGC

TGGACACCCTGCGTCTGGGTATGTTCTTCTCTCCGTCTGCGAACGCGCTGAAAAT

CACCCTGGGTAAATTCAACTCTGACCAGGTTTCTCCGTTCCGTAAAGTTCTGGAA

CAGTCTCCGTTCTTCCTGGCGGGTCGTCTGAAAGTTGAACCGGCGGAACGTATCC

TGTCTGTTGAAATCCGTAAAATCGGTAAACGTGAAAACCGTGTTGAAAACTACGC

GGCGGACGTTGAAACCTGCTTCATCGGTCAGCTGTCTTCTGACGAAAAACAGTCT

ATCCAGAAACTGGCGAACGACATCTGGGACTCTAAAGACCACGAAGAACAGCGTA

TGCTGAAAGCGGACTTCTTCGCGATCCCGCTGATCAAAGACCCGAAAGCGGTTAC

CGAAGAAGACCCGGAAAACGAAACCGCGGGTAAACAGAAACCGCTGGAACTGTGC

GTTTGCCTGGTTCCGGAACTGTACACCCGTGGTTTCGGTTCTATCGCGGACTTCC

TGGTTCAGCGTCTGACCCTGCTGCGTGACAAAATGTCTACCGACACCGCGGAAGA

CTGCCTGGAATACGTTGGTATCGAAGAAGAAAAAGGTAACGGTATGAACTCTCTG

CTGGGTACCTTCCTGAAAAACCTGCAGGGTGACGGTTTCGAACAGATCTTCCAGT

TCATGCTGGGTTCTTACGTTGGTTGGCAGGGTAAAGAAGACGTTCTGCGTGAACG

TCTGGACCTGCTGGCGGAAAAAGTTAAACGTCTGCCGAAACCGAAATTCGCGGGT

GAATGGTCTGGTCACCGTATGTTCCTGCACGGTCAGCTGAAATCTTGGTCTTCTA

ACTTCTTCCGTCTGTTCAACGAAACCCGTGAACTGCTGGAATCTATCAAATCTGA

CATCCAGCACGCGACCATGCTGATCTCTTACGTTGAAGAAAAAGGTGGTTACCAC

CCGCAGCTGCTGTCTCAGTACCGTAAACTGATGGAACAGCTGCCGGCGCTGCGTA

CCAAAGTTCTGGACCCGGAAATCGAAATGACCCACATGTCTGAAGCGGTTCGTTC

TTACATCATGATCCACAAATCTGTTGCGGGTTTCCTGCCGGACCTGCTGGAATCT

CTGGACCGTGACAAAGACCGTGAATTCCTGCTGTCTATCTTCCCGCGTATCCCGA

AAATCGACAAAAAAACCAAAGAAATCGTTGCGTGGGAACTGCCGGGTGAACCGGA

AGAAGGTTACCTGTTCACCGCGAACAACCTGTTCCGTAACTTCCTGGAAAACCCG

AAACACGTTCCGCGTTTCATGGCGGAACGTATCCCGGAAGACTGGACCCGTCTGC

GTTCTGCGCCGGTTTGGTTCGACGGTATGGTTAAACAGTGGCAGAAAGTTGTTAA

CCAGCTGGTTGAATCTCCGGGTGCGCTGTACCAGTTCAACGAATCTTTCCTGCGT

CAGCGTCTGCAGGCGATGCTGACCGTTTACAAACGTGACCTGCAGACCGAAAAAT

TCCTGAAACTGCTGGCGGACGTTTGCCGTCCGCTGGTTGACTTCTTCGGTCTGGG

TGGTAACGACATCATCTTCAAATCTTGCCAGGACCCGCGTAAACAGTGGCAGACC

GTTATCCCGCTGTCTGTTCCGGCGGACGTTTACACCGCGTGCGAAGGTCTGGCGA

TCCGTCTGCGTGAAACCCTGGGTTTCGAATGGAAAAACCTGAAAGGTCACGAACG

TGAAGACTTCCTGCGTCTGCACCAGCTGCTGGGTAACCTGCTGTTCTGGATCCGT

GACGCGAAACTGGTTGTTAAACTGGAAGACTGGATGAACAACCCGTGCGTTCAGG

AATACGTTGAAGCGCGTAAAGCGATCGACCTGCCGCTGGAAATCTTCGGTTTCGA

AGTTCCGATCTTCCTGAACGGTTACCTGTTCTCTGAACTGCGTCAGCTGGAACTG

CTGCTGCGTCGTAAATCTGTTATGACCTCTTACTCTGTTAAAACCACCGGTTCTC

CGAACCGTCTGTTCCAGCTGGTTTACCTGCCGCTGAACCCGTCTGACCCGGAAAA

AAAAAACTCTAACAACTTCCAGGAACGTCTGGACACCCCGACCGGTCTGTCTCGT

CGTTTCCTGGACCTGACCCTGGACGCGTTCGCGGGTAAACTGCTGACCGACCCGG

TTACCCAGGAACTGAAAACCATGGCGGGTTTCTACGACCACCTGTTCGGTTTCAA

ACTGCCGTGCAAACTGGCGGCGATGTCTAACCACCCGGGTTCTTCTTCTAAAATG

GTTGTTCTGGCGAAACCGAAAAAAGGTGTTGCGTCTAACATCGGTTTCGAACCGA

TCCCGGACCCGGCGCACCCGGTTTTCCGTGTTCGTTCTTCTTGGCCGGAACTGAA

ATACCTGGAAGGTCTGCTGTACCTGCCGGAAGACACCCCGCTGACCATCGAACTG

GCGGAAACCTCTGTTTCTTGCCAGTCTGTTTCTTCTGTTGCGTTCGACCTGAAAA

ACCTGACCACCATCCTGGGTCGTGTTGGTGAATTCCGTGTTACCGCGGACCAGCC

GTTCAAACTGACCCCGATCATCCCGGAAAAAGAAGAATCTTTCATCGGTAAAACC

TACCTGGGTCTGGACGCGGGTGAACGTTCTGGTGTTGGTTTCGCGATCGTTACCG

TTGACGGTGACGGTTACGAAGTTCAGCGTCTGGGTGTTCACGAAGACACCCAGCT

GATGGCGCTGCAGCAGGTTGCGTCTAAATCTCTGAAAGAACCGGTTTTCCAGCCG

CTGCGTAAAGGTACCTTCCGTCAGCAGGAACGTATCCGTAAATCTCTGCGTGGTT

GCTACTGGAACTTCTACCACGCGCTGATGATCAAATACCGTGCGAAAGTTGTTCA

CGAAGAATCTGTTGGTTCTTCTGGTCTGGTTGGTCAGTGGCTGCGTGCGTTCCAG

AAAGACCTGAAAAAAGCGGACGTTCTGCCGAAAAAAGGTGGTAAAAACGGTGTTG

ACAAAAAAAAACGTGAATCTTCTGCGCAGGACACCCTGTGGGGTGGTGCGTTCTC

TAAAAAAGAAGAACAGCAGATCGCGTTCGAAGTTCAGGCGGCGGGTTCTTCTCAG

TTCTGCCTGAAATGCGGTTGGTGGTTCCAGCTGGGTATGCGTGAAGTTAACCGTG

TTCAGGAATCTGGTGTTGTTCTGGACTGGAACCGTTCTATCGTTACCTTCCTGAT

CGAATCTTCTGGTGAAAAAGTTTACGGTTTCTCTCCGCAGCAGCTGGAAAAAGGT

TTCCGTCCGGACATCGAAACCTTCAAAAAAATGGTTCGTGACTTCATGCGTCCGC

CGATGTTCGACCGTAAAGGTCGTCCGGCGGCGGCGTACGAACGTTTCGTTCTGGG

TCGTCGTCACCGTCGTTACCGTTTCGACAAAGTTTTCGAAGAACGTTTCGGTCGT

TCTGCGCTGTTCATCTGCCCGCGTGTTGGTTGCGGTAACTTCGACCACTCTTCTG

AACAGTCTGCGGTTGTTCTGGCGCTGATCGGTTACATCGCGGACAAAGAAGGTAT

GTCTGGTAAAAAACTGGTTTACGTTCGTCTGGCGGAACTGATGGCGGAATGGAAA

CTGAAAAAACTGGAACGTTCTCGTGTTGAAGAACAGTCTTCTGCGCAGTAAGAAA

TCATCCTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATGTAGGGAGACCCTCA

GGTTAAATATTCACTCAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

78
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATGCGGAATCTAAACAG

ATGCAGTGCCGTAAATGCGGTGCGTCTATGAAATACGAAGTTATCGGTCTGGGTA

AAAAATCTTGCCGTTACATGTGCCCGGACTGCGGTAACCACACCTCTGCGCGTAA

AATCCAGAACAAAAAAAAACGTGACAAAAAATACGGTTCTGCGTCTAAAGCGCAG

TCTCAGCGTATCGCGGTTGCGGGTGCGCTGTACCCGGACAAAAAAGTTCAGACCA

TCAAAACCTACAAATACCCGGCGGACCTGAACGGTGAAGTTCACGACTCTGGTGT

TGCGGAAAAAATCGCGCAGGCGATCCAGGAAGACGAAATCGGTCTGCTGGGTCCG

TCTTCTGAATACGCGTGCTGGATCGCGTCTCAGAAACAGTCTGAACCGTACTCTG

TTGTTGACTTCTGGTTCGACGCGGTTTGCGCGGGTGGTGTTTTCGCGTACTCTGG

TGCGCGTCTGCTGTCTACCGTTCTGCAGCTGTCTGGTGAAGAATCTGTTCTGCGT

GCGGCGCTGGCGTCTTCTCCGTTCGTTGACGACATCAACCTGGCGCAGGCGGAAA

AATTCCTGGCGGTTTCTCGTCGTACCGGTCAGGACAAACTGGGTAAACGTATCGG

TGAATGCTTCGCGGAAGGTCGTCTGGAAGCGCTGGGTATCAAAGACCGTATGCGT

GAATTCGTTCAGGCGATCGACGTTGCGCAGACCGCGGGTCAGCGTTTCGCGGCGA

AACTGAAAATCTTCGGTATCTCTCAGATGCCGGAAGCGAAACAGTGGAACAACGA

CTCTGGTCTGACCGTTTGCATCCTGCCGGACTACTACGTTCCGGAAGAAAACCGT

GCGGACCAGCTGGTTGTTCTGCTGCGTCGTCTGCGTGAAATCGCGTACTGCATGG

GTATCGAAGACGAAGCGGGTTTCGAACACCTGGGTATCGACCCGGGTGCGCTGTC

TAACTTCTCTAACGGTAACCCGAAACGTGGTTTCCTGGGTCGTCTGCTGAACAAC

GACATCATCGCGCTGGCGAACAACATGTCTGCGATGACCCCGTACTGGGAAGGTC

GTAAAGGTGAACTGATCGAACGTCTGGCGTGGCTGAAACACCGTGCGGAAGGTCT

GTACCTGAAAGAACCGCACTTCGGTAACTCTTGGGCGGACCACCGTTCTCGTATC

TTCTCTCGTATCGCGGGTTGGCTGTCTGGTTGCGCGGGTAAACTGAAAATCGCGA

AAGACCAGATCTCTGGTGTTCGTACCGACCTGTTCCTGCTGAAACGTCTGCTGGA

CGCGGTTCCGCAGTCTGCGCCGTCTCCGGACTTCATCGCGTCTATCTCTGCGCTG

GACCGTTTCCTGGAAGCGGCGGAATCTTCTCAGGACCCGGCGGAACAGGTTCGTG

CGCTGTACGCGTTCCACCTGAACGCGCCGGCGGTTCGTTCTATCGCGAACAAAGC

GGTTCAGCGTTCTGACTCTCAGGAATGGCTGATCAAAGAACTGGACGCGGTTGAC

CACCTGGAATTCAACAAAGCGTTCCCGTTCTTCTCTGACACCGGTAAAAAAAAAA

AAAAAGGTGCGAACTCTAACGGTGCGCCGTCTGAAGAAGAATACACCGAAACCGA

ATCTATCCAGCAGCCGGAAGACGCGGAACAGGAAGTTAACGGTCAGGAAGGTAAC

GGTGCGTCTAAAAACCAGAAAAAATTCCAGCGTATCCCGCGTTTCTTCGGTGAAG

GTTCTCGTTCTGAATACCGTATCCTGACCGAAGCGCCGCAGTACTTCGACATGTT

CTGCAACAACATGCGTGCGATCTTCATGCAGCTGGAATCTCAGCCGCGTAAAGCG

CCGCGTGACTTCAAATGCTTCCTGCAGAACCGTCTGCAGAAACTGTACAAACAGA

CCTTCCTGAACGCGCGTTCTAACAAATGCCGTGCGCTGCTGGAATCTGTTCTGAT

CTCTTGGGGTGAATTCTACACCTACGGTGCGAACGAAAAAAAATTCCGTCTGCGT

CACGAAGCGTCTGAACGTTCTTCTGACCCGGACTACGTTGTTCAGCAGGCGCTGG

AAATCGCGCGTCGTCTGTTCCTGTTCGGTTTCGAATGGCGTGACTGCTCTGCGGG

TGAACGTGTTGACCTGGTTGAAATCCACAAAAAAGCGATCTCTTTCCTGCTGGCG

ATCACCCAGGCGGAAGTTTCTGTTGGTTCTTACAACTGGCTGGGTAACTCTACCG

TTTCTCGTTACCTGTCTGTTGCGGGTACCGACACCCTGTACGGTACCCAGCTGGA

AGAATTCCTGAACGCGACCGTTCTGTCTCAGATGCGTGGTCTGGCGATCCGTCTG

TCTTCTCAGGAACTGAAAGACGGTTTCGACGTTCAGCTGGAATCTTCTTGCCAGG

ACAACCTGCAGCACCTGCTGGTTTACCGTGCGTCTCGTGACCTGGCGGCGTGCAA

ACGTGCGACCTGCCCGGCGGAACTGGACCCGAAAATCCTGGTTCTGCCGGTTGGT

GCGTTCATCGCGTCTGTTATGAAAATGATCGAACGTGGTGACGAACCGCTGGCGG

GTGCGTACCTGCGTCACCGTCCGCACTCTTTCGGTTGGCAGATCCGTGTTCGTGG

TGTTGCGGAAGTTGGTATGGACCAGGGTACCGCGCTGGCGTTCCAGAAACCGACC

GAATCTGAACCGTTCAAAATCAAACCGTTCTCTGCGCAGTACGGTCCGGTTCTGT

GGCTGAACTCTTCTTCTTACTCTCAGTCTCAGTACCTGGACGGTTTCCTGTCTCA

GCCGAAAAACTGGTCTATGCGTGTTCTGCCGCAGGCGGGTTCTGTTCGTGTTGAA

CAGCGTGTTGCGCTGATCTGGAACCTGCAGGCGGGTAAAATGCGTCTGGAACGTT

CTGGTGCGCGTGCGTTCTTCATGCCGGTTCCGTTCTCTTTCCGTCCGTCTGGTTC

TGGTGACGAAGCGGTTCTGGCGCCGAACCGTTACCTGGGTCTGTTCCCGCACTCT

GGTGGTATCGAATACGCGGTTGTTGACGTTCTGGACTCTGCGGGTTTCAAAATCC

TGGAACGTGGTACCATCGCGGTTAACGGTTTCTCTCAGAAACGTGGTGAACGTCA

GGAAGAAGCGCACCGTGAAAAACAGCGTCGTGGTATCTCTGACATCGGTCGTAAA

AAACCGGTTCAGGCGGAAGTTGACGCGGCGAACGAACTGCACCGTAAATACACCG

ACGTTGCGACCCGTCTGGGTTGCCGTATCGTTGTTCAGTGGGCGCCGCAGCCGAA

ACCGGGTACCGCGCCGACCGCGCAGACCGTTTACGCGCGTGCGGTTCGTACCGAA

GCGCCGCGTTCTGGTAACCAGGAAGACCACGCGCGTATGAAATCTTCTTGGGGTT

ACACCTGGGGTACCTACTGGGAAAAACGTAAACCGGAAGACATCCTGGGTATCTC

TACCCAGGTTTACTGGACCGGTGGTATCGGTGAATCTTGCCCGGCGGTTGCGGTT

GCGCTGCTGGGTCACATCCGTGCGACCTCTACCCAGACCGAATGGGAAAAAGAAG

AAGTTGTTTTCGGTCGTCTGAAAAAATTCTTCCCGTCTTAAGAAATCATCCTTAG

CGAAAGCTAAGGATTTTTTTTATCTGAAATGTAGGGAGACCCTCAGGTTAAATAT

TCACTCAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

79
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATGAAAAACGTATCAAC

AAAATCCGTAAAAAACTGTCTGCGGACAACGCGACCAAACCGGTTTCTCGTTCTG

GTCCGATGAAAACCCTGCTGGTTCGTGTTATGACCGACGACCTGAAAAAACGTCT

GGAAAAACGTCGTAAAAAACCGGAAGTTATGCCGCAGGTTATCTCTAACAACGCG

GCGAACAACCTGCGTATGCTGCTGGACGACTACACCAAAATGAAAGAAGCGATCC

TGCAGGTTTACTGGCAGGAATTCAAAGACGACCACGTTGGTCTGATGTGCAAATT

CGCGCAGCCGGCGTCTAAAAAAATCGACCAGAACAAACTGAAACCGGAAATGGAC

GAAAAAGGTAACCTGACCACCGCGGGTTTCGCGTGCTCTCAGTGCGGTCAGCCGC

TGTTCGTTTACAAACTGGAACAGGTTTCTGAAAAAGGTAAAGCGTACACCAACTA

CTTCGGTCGTTGCAACGTTGCGGAACACGAAAAACTGATCCTGCTGGCGCAGCTG

AAACCGGAAAAAGACTCTGACGAAGCGGTTACCTACTCTCTGGGTAAATTCGGTC

AGCGTGCGCTGGACTTCTACTCTATCCACGTTACCAAAGAATCTACCCACCCGGT

TAAACCGCTGGCGCAGATCGCGGGTAACCGTTACGCGTCTGGTCCGGTTGGTAAA

GCGCTGTCTGACGCGTGCATGGGTACCATCGCGTCTTTCCTGTCTAAATACCAGG

ACATCATCATCGAACACCAGAAAGTTGTTAAAGGTAACCAGAAACGTCTGGAATC

TCTGCGTGAACTGGCGGGTAAAGAAAACCTGGAATACCCGTCTGTTACCCTGCCG

CCGCAGCCGCACACCAAAGAAGGTGTTGACGCGTACAACGAAGTTATCGCGCGTG

TTCGTATGTGGGTTAACCTGAACCTGTGGCAGAAACTGAAACTGTCTCGTGACGA

CGCGAAACCGCTGCTGCGTCTGAAAGGTTTCCCGTCTTTCCCGGTTGTTGAACGT

CGTGAAAACGAAGTTGACTGGTGGAACACCATCAACGAAGTTAAAAAACTGATCG

ACGCGAAACGTGACATGGGTCGTGTTTTCTGGTCTGGTGTTACCGCGGAAAAACG

TAACACCATCCTGGAAGGTTACAACTACCTGCCGAACGAAAACGACCACAAAAAA

CGTGAAGGTTCTCTGGAAAACCCGAAAAAACCGGCGAAACGTCAGTTCGGTGACC

TGCTGCTGTACCTGGAAAAAAAATACGCGGGTGACTGGGGTAAAGTTTTCGACGA

AGCGTGGGAACGTATCGACAAAAAAATCGCGGGTCTGACCTCTCACATCGAACGT

GAAGAAGCGCGTAACGCGGAAGACGCGCAGTCTAAAGCGGTTCTGACCGACTGGC

TGCGTGCGAAAGCGTCTTTCGTTCTGGAACGTCTGAAAGAAATGGACGAAAAAGA

ATTCTACGCGTGCGAAATCCAGCTGCAGAAATGGTACGGTGACCTGCGTGGTAAC

CCGTTCGCGGTTGAAGCGGAAAACCGTGTTGTTGACATCTCTGGTTTCTCTATCG

GTTCTGACGGTCACTCTATCCAGTACCGTAACCTGCTGGCGTGGAAATACCTGGA

AAACGGTAAACGTGAATTCTACCTGCTGATGAACTACGGTAAAAAAGGTCGTATC

CGTTTCACCGACGGTACCGACATCAAAAAATCTGGTAAATGGCAGGGTCTGCTGT

ACGGTGGTGGTAAAGCGAAAGTTATCGACCTGACCTTCGACCCGGACGACGAACA

GCTGATCATCCTGCCGCTGGCGTTCGGTACCCGTCAGGGTCGTGAATTCATCTGG

AACGACCTGCTGTCTCTGGAAACCGGTCTGATCAAACTGGCGAACGGTCGTGTTA

TCGAAAAAACCATCTACAACAAAAAAATCGGTCGTGACGAACCGGCGCTGTTCGT

TGCGCTGACCTTCGAACGTCGTGAAGTTGTTGACCCGTCTAACATCAAACCGGTT

AACCTGATCGGTGTTGACCGTGGTGAAAACATCCCGGCGGTTATCGCGCTGACCG

ACCCGGAAGGTTGCCCGCTGCCGGAATTCAAAGACTCTTCTGGTGGTCCGACCGA

CATCCTGCGTATCGGTGAAGGTTACAAAGAAAAACAGCGTGCGATCCAGGCGGCG

AAAGAAGTTGAACAGCGTCGTGCGGGTGGTTACTCTCGTAAATTCGCGTCTAAAT

CTCGTAACCTGGCGGACGACATGGTTCGTAACTCTGCGCGTGACCTGTTCTACCA

CGCGGTTACCCACGACGCGGTTCTGGTTTTCGAAAACCTGTCTCGTGGTTTCGGT

CGTCAGGGTAAACGTACCTTCATGACCGAACGTCAGTACACCAAAATGGAAGACT

GGCTGACCGCGAAACTGGCGTACGAAGGTCTGACCTCTAAAACCTACCTGTCTAA

AACCCTGGCGCAGTACACCTCTAAAACCTGCTCTAACTGCGGTTTCACCATCACC

ACCGCGGACTACGACGGTATGCTGGTTCGTCTGAAAAAAACCTCTGACGGTTGGG

CGACCACCCTGAACAACAAAGAACTGAAAGCGGAAGGTCAGATCACCTACTACAA

CCGTTACAAACGTCAGACCGTTGAAAAAGAACTGTCTGCGGAACTGGACCGTCTG

TCTGAAGAATCTGGTAACAACGACATCTCTAAATGGACCAAAGGTCGTCGTGACG

AAGCGCTGTTCCTGCTGAAAAAACGTTTCTCTCACCGTCCGGTTCAGGAACAGTT

CGTTTGCCTGGACTGCGGTCACGAAGTTCACGCGGACGAACAGGCGGCGCTGAAC

ATCGCGCGTTCTTGGCTGTTCCTGAACTCTAACTCTACCGAATTCAAATCTTACA

AATCTGGTAAACAGCCGTTCGTTGGTGCGTGGCAGGCGTTCTACAAACGTCGTCT

GAAAGAAGTTTGGAAACCGAACGCGTAAGAAATCATCCTTAGCGAAAGCTAAGGA

TTTTTTTTATCTGAAATGTAGGGAGACCCTCAGGTTAAATATTCACTCAGGAAGT

TATTACTCAGGAAGCAAAGAGGATTACA

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

NO:
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

80
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGCTAGCAG

TAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGAAC

TTTAAGAGGAGGATATACCATGCACCATCATCATCACCATAAACGTATCAACAAA

ATCCGTCGTCGTCTGGTTAAAGACTCTAACACCAAAAAAGCGGGTAAAACCGGTC

CGATGAAAACCCTGCTGGTTCGTGTTATGACCCCGGACCTGCGTGAACGTCTGGA

AAACCTGCGTAAAAAACCGGAAAACATCCCGCAGCCGATCTCTAACACCTCTCGT

GCGAACCTGAACAAACTGCTGACCGACTACACCGAAATGAAAAAAGCGATCCTGC

ACGTTTACTGGGAAGAATTCCAGAAAGACCCGGTTGGTCTGATGTCTCGTGTTGC

GCAGCCGGCGCCGAAAAACATCGACCAGCGTAAACTGATCCCGGTTAAAGACGGT

AACGAACGTCTGACCTCTTCTGGTTTCGCGTGCTCTCAGTGCTGCCAGCCGCTGT

ACGTTTACAAACTGGAACAGGTTAACGACAAAGGTAAACCGCACACCAACTACTT

CGGTCGTTGCAACGTTTCTGAACACGAACGTCTGATCCTGCTGTCTCCGCACAAA

CCGGAAGCGAACGACGAACTGGTTACCTACTCTCTGGGTAAATTCGGTCAGCGTG

CGCTGGACTTCTACTCTATCCACGTTACCCGTGAATCTAACCACCCGGTTAAACC

GCTGGAACAGATCGGTGGTAACTCTTGCGCGTCTGGTCCGGTTGGTAAAGCGCTG

TCTGACGCGTGCATGGGTGCGGTTGCGTCTTTCCTGACCAAATACCAGGACATCA

TCCTGGAACACCAGAAAGTTATCAAAAAAAACGAAAAACGTCTGGCGAACCTGAA

AGACATCGCGTCTGCGAACGGTCTGGCGTTCCCGAAAATCACCCTGCCGCCGCAG

CCGCACACCAAAGAAGGTATCGAAGCGTACAACAACGTTGTTGCGCAGATCGTTA

TCTGGGTTAACCTGAACCTGTGGCAGAAACTGAAAATCGGTCGTGACGAAGCGAA

ACCGCTGCAGCGTCTGAAAGGTTTCCCGTCTTTCCCGCTGGTTGAACGTCAGGCG

AACGAAGTTGACTGGTGGGACATGGTTTGCAACGTTAAAAAACTGATCAACGAAA

AAAAAGAAGACGGTAAAGTTTTCTGGCAGAACCTGGCGGGTTACAAACGTCAGGA

AGCGCTGCTGCCGTACCTGTCTTCTGAAGAAGACCGTAAAAAAGGTAAAAAATTC

GCGCGTTACCAGTTCGGTGACCTGCTGCTGCACCTGGAAAAAAAACACGGTGAAG

ACTGGGGTAAAGTTTACGACGAAGCGTGGGAACGTATCGACAAAAAAGTTGAAGG

TCTGTCTAAACACATCAAACTGGAAGAAGAACGTCGTTCTGAAGACGCGCAGTCT

AAAGCGGCGCTGACCGACTGGCTGCGTGCGAAAGCGTCTTTCGTTATCGAAGGTC

TGAAAGAAGCGGACAAAGACGAATTCTGCCGTTGCGAACTGAAACTGCAGAAATG

GTACGGTGACCTGCGTGGTAAACCGTTCGCGATCGAAGCGGAAAACTCTATCCTG

GACATCTCTGGTTTCTCTAAACAGTACAACTGCGCGTTCATCTGGCAGAAAGACG

GTGTTAAAAAACTGAACCTGTACCTGATCATCAACTACTTCAAAGGTGGTAAACT

GCGTTTCAAAAAAATCAAACCGGAAGCGTTCGAAGCGAACCGTTTCTACACCGTT

ATCAACAAAAAATCTGGTGAAATCGTTCCGATGGAAGTTAACTTCAACTTCGACG

ACCCGAACCTGATCATCCTGCCGCTGGCGTTCGGTAAACGTCAGGGTCGTGAATT

CATCTGGAACGACCTGCTGTCTCTGGAAACCGGTTCTCTGAAACTGGCGAACGGT

CGTGTTATCGAAAAAACCCTGTACAACCGTCGTACCCGTCAGGACGAACCGGCGC

TGTTCGTTGCGCTGACCTTCGAACGTCGTGAAGTTCTGGACTCTTCTAACATCAA

ACCGATGAACCTGATCGGTATCGACCGTGGTGAAAACATCCCGGCGGTTATCGCG

CTGACCGACCCGGAAGGTTGCCCGCTGTCTCGTTTCAAAGACTCTCTGGGTAACC

CGACCCACATCCTGCGTATCGGTGAATCTTACAAAGAAAAACAGCGTACCATCCA

GGCGGCGAAAGAAGTTGAACAGCGTCGTGCGGGTGGTTACTCTCGTAAATACGCG

TCTAAAGCGAAAAACCTGGCGGACGACATGGTTCGTAACACCGCGCGTGACCTGC

TGTACTACGCGGTTACCCAGGACGCGATGCTGATCTTCGAAAACCTGTCTCGTGG

TTTCGGTCGTCAGGGTAAACGTACCTTCATGGCGGAACGTCAGTACACCCGTATG

GAAGACTGGCTGACCGCGAAACTGGCGTACGAAGGTCTGCCGTCTAAAACCTACC

TGTCTAAAACCCTGGCGCAGTACACCTCTAAAACCTGCTCTAACTGCGGTTTCAC

CATCACCTCTGCGGACTACGACCGTGTTCTGGAAAAACTGAAAAAAACCGCGACC

GGTTGGATGACCACCATCAACGGTAAAGAACTGAAAGTTGAAGGTCAGATCACCT

ACTACAACCGTTACAAACGTCAGAACGTTGTTAAAGACCTGTCTGTTGAACTGGA

CCGTCTGTCTGAAGAATCTGTTAACAACGACATCTCTTCTTGGACCAAAGGTCGT

TCTGGTGAAGCGCTGTCTCTGCTGAAAAAACGTTTCTCTCACCGTCCGGTTCAGG

AAAAATTCGTTTGCCTGAACTGCGGTTTCGAAACCCACGCGGACGAACAGGCGGC

GCTGAACATCGCGCGTTCTTGGCTGTTCCTGCGTTCTCAGGAATACAAAAAATAC

CAGACCAACAAAACCACCGGTAACACCGACAAACGTGCGTTCGTTGAAACCTGGC

AGTCTTTCTACCGTAAAAAACTGAAAGAAGTTTGGAAACCGGAAATCATCCTTAG

CGAAAGCTAAGGATTTTTTTTATCTGAAATGTAGGGAGACCCTCAGGTTAAATAT

TCACTCAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACA

SEQ
tgccgtcactgcgtcttttactggctcttctcgctaaccaaaccggtaaccccgc

ID
ttattaaaagcattctgtaacaaagcgggaccaaagccatgacaaaaacgcgtaa

NO:
caaaagtgtctataatcacggcagaaaagtccacattgattatttgcacggcgtc

81
acactttgctatgccatagcatttttatccataagattagcggatcctacctgac

gctttttatcgcaactctctactgtttctccatacccgtttttttgggctagcac

cgcctatctcgtgtgagataggcggagatacgaactttaagAAGGAGatatacc

SEQ
TGCCGTCACTGCGTCTTTTACTGGCTCTTCTCGCTAACCAAACCGGTAACCCCGC

ID
TTATTAAAAGCATTCTGTAACAAAGCGGGACCAAAGCCATGACAAAAACGCGTAA

NO:
CAAAAGTGTCTATAATCACGGCAGAAAAGTCCACATTGATTATTTGCACGGCGTC

82
ACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGATCCTACCTGAC

GCTTTTTATCGCAACTCTCTACTGTTTCTCCATACCCGTTTTTTTGGGTAGCGGA

TCCTACCTGAC

SEQ
AATCAGGAGAGCGTTTTCAATCCTACCTCTGGCGCAGTTGATATGTCAAACAGGT

ID
TTCTAGAGCACAGCTAACACCACGTCGTCCCTATCTGCTGCCCTAGGTCTATGAG

NO:
TGGTTGCTGGATAACTTTACGGGCATGCATAAGGCTCGTAATATATATTCAGGGA

83
GACCACAACGGTTTCCCTCTACAAATAATTTTGTTTAACTTTTACTAGAGCTAGC

AGTAATACGACTCACTATAGGGGTCTCATCTCGTGTGAGATAGGCGGAGATACGA

ACTTTAAGAGGAGGATATACCA

SEQ
GTTTGAGAGATATGTAAATTCAAAGGATAATCAAAC

ID

NO:

84

SEQ
actacattttttaagacctaattttgagt

ID

NO:

85

SEQ
ctcaaaactcattcgaatctctactctttgtagat

ID

NO:

86

SEQ
CTCTAGCAGGCCTGGCAAATTTCTACTGTTGTAGAT

ID

NO:

87

SEQ
CCGTCTAAAACTCATTCAGAATTTCTACTAGTGTAGAT

ID

NO:

88

SEQ
GTCTAGGTACTCTCTTTAATTTCTACTATTGT

ID

NO:

89

SEQ
gttaagttatatagaataatttctactgttgtaga

ID

NO:

90

SEQ
gtttaaaaccactttaaaatttctactattgta

ID

NO:

91

SEQ
GTTTGAGAATGATGTAAAAATGTATGGTACACAGAAATGTTTTAATACCATATTT

ID
TTACATCACTCTCAAACATACATCTCTTGTTACTGTTTATCGTATCCAGATTAAA

NO:
TTTCACGTTTTT

92

SEQ
CTCTACAACTGATAAAGAATTTCTACTTTTGTAGAT

ID

NO:

93

SEQ
GTCTGGCCCCAAATTTTAATTTCTACTGTTGTAGAT

ID

NO:

94

SEQ
GTCAAAAGACCTTTTTAATTTCTACTCTTGTAGAT

ID

NO:

95

SEQ
GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCA

ID
AAGCCCGTTGAGCTTCTACGGAAGTGGCAC

NO:

96

SEQ
CGAGGTTCTGTCTTTTGGTCAGGACAACCGTCTAGCTATAAGTGCTGCAGGGGTG

ID
TGAGAAACTCCTATTGCTGGACGATGTCTCTTTTAACGAGGCATTAGCAC

NO:

97

SEQ
GAACGAGGGACGTTTTGTCTCCAATGATTTTGCTATGACGACCTCGAACTGTGCC

ID
TTCAAGTCTGAGGCGAAAAAGAAATGGAAAAAAGTGTCTCATCGCTCTACCTCGT

NO:
AGTTAGAGG

98

SEQ
AATTACTGATGTTGTGATGAAGG

ID

NO:

99

SEQ
TATACCATAAGGATTTAAAGACT

ID

NO:

100

SEQ
GTCTTTACTCTCACCTTTCCACCTG

ID

NO:

101

SEQ
ATTTGAAGGTATCTCCGATAAGTAAAACGCATCAAAG

ID

NO:

102

SEQ
GTTTGAAGATATCTCCGATAAATAAGAAGCATCAAAG

ID

NO:

103

SEQ
TTGTTTTAATACCATATTTTTACATCACTCTCAAAC

ID

NO:

104

SEQ
AAAGAACGCTCGCTCAGTGTTCTGACCTTTCGAGCGCCTGTTCAGGGCGAAAACC

ID
CTGGGAGGCGCTCGAATCATAGGTGGGACAAGGGATTCGCGGCGAAAA

NO:

105

SEQ
GTTTGAGAATGATGTAAAAATGTATGGTACACAGAAATGTTTTAATACCATATTT

ID
TTACATCACTCTCAAACATACATCTCTTGTTACTGTTTATCGTATCCAGATTAAA

NO:
TTTCACGTTTTT

106

SEQ
GTCTAGAGGACAGAATTTTTCAACGGGTGTGCCAATGGCCACTTTCCAGGTGGCA

ID
AAGCCCGTTGAGCTTCTACGGAAGTGGCAC

NO:

107

SEQ
MSIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKKAKQIID

ID
KYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFKSAKDTIKKQIS

NO:
EYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNGIELFKANSDITDIDEA

108
LEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSIIYRIVDDNLPKFLENKAKYES

LKDKAPEAINYEQIKKDLAEELTFDIDYKTSEVNQRVFSLDEVFEIANFNNYLNQ

SGITKFNTIIGGKFVNGENTKRKGINEYINLYSQQINDKTLKKYKMSVLFKQILS

DTESKSFVIDKLEDDSDVVTTMQSFYEQIAAFKTVEEKSIKETLSLLFDDLKAQK

LDLSKIYFKNDKSLTDLSQQVEDDYSVIGTAVLEYITQQIAPKNLDNPSKKEQEL

IAKKTEKAKYLSLETIKLALEEFNKHRDIDKQCRFEEILANFAAIPMIFDEIAQN

KDNLAQISIKYQNQGKKDLLQASAEDDVKAIKDLLDQTNNLLHKLKIFHISQSED

KANILDKDEHFYLVFEECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENSTL

ANGWDKNKEPDNTAILFIKDDKYYLGVMNKKNNKIFDDKAIKENKGEGYKKIVYK

LLPGANKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGSPQKGYEKFEFNIE

DCRKFIDFYKQSISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKLTFENIS

ESYIDSVVNQGKLYLFQIYNKDFSAYSKGRPNLHTLYWKALFDERNLQDVVYKLN

GEAELFYRKQSIPKKITHPAKEAIANKNKDNPKKESVFEYDLIKDKRFTEDKFFF

HCPITINFKSSGANKENDEINLLLKEKANDVHILSIDRGERHLAYYTLVDGKGNI

IKQDTFNIIGNDRMKTNYHDKLAAIEKDRDSARKDWKKINNIKEMKEGYLSQVVH

EIAKLVIEYNAIVVFEDLNFGFKRGRFKVEKQVYQKLEKMLIEKLNYLVFKDNEF

DKTGGVLRAYQLTAPFETFKKMGKQTGIIYYVPAGFTSKICPVTGFVNQLYPKYE

SVSKSQEFFSKFDKICYNLDKGYFEFSFDYKNFGDKAAKGKWTIASFGSRLINFR

NSDKNHNWDTREVYPTKELEKLLKDYSIEYGHGECIKAAICGESDKKFFAKLTSV

LNTILQMRNSKTGTELDYLISPVADVNGNFFDSRQAPKNMPQDADANGAYHIGLK

GLMLLGRIKNNQEGKKLNLVIKNEEYFEFVQNRNN

SEQ
MSIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKKAKQIID

ID
KYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFKSAKDTIKKQIS

NO:
EYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNGIELFKANSDITDIDEA

109
LEIIKSFKGWTTYFKGFHENRKNVYSSDDIPTSIIYRIVDDNLPKFLENKAKYES

LKDKAPEAINYEQIKKDLAEELTFDIDYKTSEVNQRVFSLDEVFEIANFNNYLNQ

SGITKFNTIIGGKFVNGENTKRKGINEYINLYSQQINDKTLKKYKMSVLFKQILS

DTESKSFVIDKLEDDSDVVTTMQSFYEQIAAFKTVEEKSIKETLSLLFDDLKAQK

LDLSKIYFKNDKSLTDLSQQVEDDYSVIGTAVLEYITQQVAPKNLDNPSKKEQDL

IAKKTEKAKYLSLETIKLALEEFNKHRDIDKQCRFEEILANFAAIPMIFDEIAQN

KDNLAQISLKYQNQGKKDLLQASAEEDVKAIKDLLDQTNNLLHRLKIFHISQSED

KANILDKDEHFYLVFEECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENSTL

ANGWDKNKEPDNTAILFIKDDKYYLGVMNKKNNKIFDDKAIKENKGEGYKKIVYK

LLPGANKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGNPQKGYEKFEFNIE

DCRKFIDFYKESISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKLTFENIS

ESYIDSVVNQGKLYLFQIYNKDFSAYSKGRPNLHTLYWKALFDERNLQDVVYKLN

GEAELFYRKQSIPKKITHPAKEAIANKNKDNPKKESVFEYDLIKDKRFTEDKFFF

HCPITINFKSSGANKENDEINLLLKEKANDVHILSIDRGERHLAYYTLVDGKGNI

IKQDTFNIIGNDRMKTNYHDKLAAIEKDRDSARKDWKKINNIKEMKEGYLSQVVH

EIAKLVIEHNAIVVFEDLNFGFKRGRFKVEKQVYQKLEKMLIEKLNYLVFKDNEF

DKTGGVLRAYQLTAPFETFKKMGKQTGIIYYVPAGFTSKICPVTGFVNQLYPKYE

SVSKSQEFFSKFDKICYNLDKGYFEFSFDYKNFGDKAAKGKWTIASFGSRLINFR

NSDKNHNWDTREVYPTKELEKLLKDYSIEYGHGECIKAAICGESDKKFFAKLTSV

LNTILQMRNSKTGTELDYLISPVADVNGNFFDSRQAPKNMPQDADANGAYHIGLK

GLMLLDRIKNNQEGKKLNLVIKNEEYFEFVQNRNN

SEQ
MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDS

ID
GETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEED

NO:
KKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFR

110
GHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSR

RLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDL

DNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQ

DLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKI

EKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERM

TNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVD

LLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKD

FLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG

RLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSG

QGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTT

QKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVD

QELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMK

NYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQIL

DSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLN

AVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNF

FKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEV

QTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSK

KLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGR

KRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHY

LDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA

PAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

SEQ
PKKKRKV

ID

NO:

111

SEQ
KRPAATKKAGQAKKKK

ID

NO:

112

SEQ
PAAKRVKLD

ID

NO:

113

SEQ
RQRRNELKRSP

ID

NO:

114

SEQ
NQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGY

ID

NO:

115

SEQ
RMRIZFKNKGKDTAELRRRRVEVSVELRKAKKDEQILKRRNV

ID

NO:

116

SEQ
VSRKRPRP

ID

NO:

117

SEQ
PPKKARED

ID

NO:

118

SEQ
PQPKKKPL

ID

NO:

119

SEQ
SALIKKKKKMAP

ID

NO:

120

SEQ
DRLRR

ID

NO:

121

SEQ
PKQKKRK

ID

NO:

122

SEQ
RKLKKKIKKL

ID

NO:

123

SEQ
REKKKFLKRR

ID

NO:

124

SEQ
KRKGDEVDGVDEVAKKKSKK

ID

NO:

125

SEQ
RKCLQAGMNLEARKTKK

ID

NO:

126

SEQ
ATGGGTAAGATGTATTATCTGGGTTTGGATATAGGCACTAACTCTGTGGGATATG

ID
CAGTAACTGATCCCTCGTATCACTTGTTAAAGTTCAAAGGCGAACCCATGTGGGG

NO:
AGCACATGTATTTGCTGCGGGTAATCAGAGTGCCGAAAGGCGATCTTTCAGAACA

127
TCCAGGAGGCGATTAGATAGGAGACAGCAAAGAGTAAAGCTTGTGCAAGAGATCT

TTGCTCCTGTCATTTCACCTATAGACCCTCGTTTTTTTATAAGATTGCACGAATC

GGCTCTATGGAGAGACGATGTTGCCGAAACAGATAAACATATCTTTTTCAATGAT

CCCACTTATACAGACAAGGAATACTACTCCGACTACCCGACAATTCATCATTTGA

TCGTCGATCTTATGGAGAGCTCTGAAAAGCATGACCCCCGACTTGTCTATTTGGC

TGTAGCTTGGTTAGTTGCTCATAGAGGTCATTTCTTGAATGAAGTAGATAAAGAC

AATATAGGTGATGTACTTTCTTTTGATGCTTTCTACCCGGAATTTTTGGCCTTTT

TGTCAGACAATGGCGTCAGTCCCTGGGTCTGTGAGTCGAAGGCCCTTCAAGCTAC

TCTGCTGTCTAGGAATAGCGTCAACGACAAATATAAAGCATTAAAATCGCTGATA

TTCGGATCGCAAAAACCGGAAGATAACTTTGACGCTAACATCTCTGAAGATGGTT

TAATCCAATTGCTGGCGGGTAAGAAAGTTAAAGTAAACAAACTATTCCCACAAGA

GTCCAACGATGCTAGCTTTACGTTGAATGATAAAGAAGACGCTATTGAAGAAATT

CTAGGTACTTTAACGCCTGACGAGTGCGAATGGATCGCTCATATTCGCAGATTGT

TCGATTGGGCCATCATGAAACACGCGCTAAAGGATGGCAGGACGATATCTGAATC

AAAAGTGAAGCTATACGAGCAGCATCATCATGACTTGACTCAGTTAAAGTACTTT

GTGAAGACCTACCTAGCTAAAGAGTATGATGATATCTTCAGAAACGTAGACTCCG

AGACAACTAAAAATTATGTAGCTTATTCTTACCATGTGAAGGAAGTGAAAGGCAC

ATTACCAAAAAATAAAGCAACGCAAGAAGAATTTTGTAAATACGTCCTTGGCAAA

GTCAAAAACATTGAATGTTCCGAAGCAGACAAGGTTGATTTTGATGAAATGATAC

AACGACTTACGGACAATTCTTTTATGCCAAAGCAAGTCTCAGGTGAAAATAGAGT

AATACCATACCAGTTGTACTACTATGAATTAAAGACAATTTTAAACAAAGCCGCC

TCATATCTACCTTTTTTGACACAATGCGGTAAAGATGCTATTTCTAACCAAGACA

AATTACTGTCTATAATGACATTTCGCATACCATATTTCGTCGGCCCTTTAAGGAA

AGATAATTCAGAACATGCCTGGTTGGAACGTAAAGCGGGTAAAATTTACCCGTGG

AACTTTAATGATAAAGTAGATCTTGATAAATCGGAGGAAGCCTTTATCCGTAGGA

TGACCAATACTTGCACGTATTACCCAGGAGAAGACGTGTTACCATTAGATTCACT

TATCTATGAAAAGTTTATGATCTTGAATGAGATAAACAATATTAGGATTGACGGA

TACCCCATTTCTGTTGATGTGAAACAACAAGTATTTGGTTTATTTGAGAAGAAAA

GGCGAGTAACAGTTAAGGATATTCAAAATCTACTATTATCTCTTGGAGCGTTGGA

TAAACACGGTAAGCTGACTGGTATTGACACGACAATACACTCTAATTATAACACT

TATCATCATTTTAAATCTCTTATGGAGCGGGGAGTATTGACCAGAGATGATGTGG

AAAGAATAGTGGAAAGAATGACATATTCTGACGATACTAAGAGGGTCAGACTGTG

GTTAAATAATAATTATGGAACTCTAACAGCTGACGATGTTAAGCATATCTCAAGA

CTCAGAAAACACGATTTCGGCCGTTTGTCTAAAATGTTTTTGACAGGATTGAAAG

GTGTTCATAAGGAGACAGGCGAGAGAGCAAGTATACTGGATTTTATGTGGAATAC

TAACGACAATTTAATGCAACTACTGTCCGAATGTTACACATTCTCGGATGAGATC

ACCAAATTACAAGAGGCCTACTACGCAAAAGCTCAATTATCGCTAAATGACTTCT

TGGACTCTATGTATATATCAAACGCCGTTAAGAGACCTATTTATCGGACCTTAGC

GGTAGTAAATGATATTAGAAAGGCATGCGGGACGGCACCTAAAAGAATTTTCATC

GAGATGGCGCGAGATGGAGAGTCTAAGAAGAAAAGATCTGTGACTCGTAGAGAGC

AAATTAAAAATCTCTATAGATCAATTCGTAAAGACTTTCAACAAGAAGTTGATTT

TCTGGAAAAGATATTGGAAAATAAGAGTGACGGGCAGCTTCAGTCTGACGCTTTA

TATTTGTATTTTGCTCAATTAGGCAGAGACATGTACACAGGTGATCCAATCAAAT

TAGAACATATTAAAGACCAATCTTTTTACAACATTGATCATATTTATCCTCAATC

GATGGTGAAAGATGACAGTTTGGATAACAAGGTACTAGTCCAAAGCGAAATCAAT

GGCGAAAAGAGTTCGCGCTATCCATTAGACGCAGCCATTAGAAACAAAATGAAGC

CGTTGTGGGATGCCTACTATAATCATGGATTAATTTCTCTTAAGAAATACCAGCG

TTTGACGAGATCTACTCCATTTACGGACGACGAGAAGTGGGATTTTATCAATCGT

CAGCTAGTTGAAACTAGGCAATCTACTAAAGCTTTAGCAATATTGTTAAAGCGTA

AGTTTCCAGATACTGAAATAGTTTACTCAAAGGCTGGACTATCCAGCGATTTTAG

ACATGAATTCGGCCTGGTTAAGAGTAGGAATATTAATGATCTACACCATGCTAAA

GATGCCTTTCTCGCAATAGTTACTGGGAACGTTTATCATGAAAGATTTAATAGAA

GATGGTTTATGGTTAACCAGCCATACTCTGTGAAAACTAAGACATTGTTTACCCA

TTCAATTAAGAATGGCAACTTTGTCGCTTGGAATGGAGAAGAAGATCTTGGACGT

ATCGTAAAGATGTTGAAACAAAACAAGAACACAATCCACTTCACCAGGTTTTCCT

TTGATAGGAAGGAGGGATTGTTCGATATTCAACCTCTCAAAGCTTCTACCGGATT

GGTTCCACGAAAAGCAGGGTTGGATGTTGTTAAATATGGAGGATACGATAAAAGC

ACTGCCGCGTATTATTTATTAGTACGTTTTACACTCGAGGATAAGAAGACTCAAC

ACAAATTGATGATGATTCCTGTTGAAGGTCTCTACAAAGCACGTATTGACCATGA

TAAAGAGTTTTTAACAGATTATGCTCAGACCACGATCAGCGAAATTCTTCAAAAG

GACAAGCAGAAAGTGATCAACATCATGTTCCCTATGGGCACGAGACATATCAAAC

TGAATTCGATGATTTCTATTGATGGATTCTATCTTTCTATTGGTGGGAAGAGTAG

CAAAGGTAAGTCAGTACTATGTCATGCTATGGTGCCATTAATCGTCCCACACAAG

ATAGAATGTTATATCAAGGCTATGGAATCGTTTGCAAGAAAATTCAAAGAAAATA

ATAAATTGAGGATCGTTGAAAAGTTTGATAAAATAACTGTTGAAGATAACTTGAA

CTTATACGAGCTTTTTCTACAAAAGTTGCAACATAACCCATATAATAAATTTTTC

TCTACACAATTTGATGTGTTGACGAACGGTAGAAGTACATTCACCAAATTGTCTC

CAGAGGAGCAAGTCCAGACTTTACTTAATATACTGAGTATATTTAAAACTTGTCG

TTCTTCTGGGTGTGATTTAAAATCAATAAATGGTTCCGCTCAAGCGGCTAGAATT

ATGATATCCGCTGATTTAACTGGCTTATCAAAAAAGTATTCAGATATTAGATTAG

TTGAGCAAAGCGCATCAGGTCTATTTGTTTCAAAATCTCAAAATCTCTTGGAATA

CTTGCCAAAAAAGAAAAGGAAAGTTTAG

SEQ
ATGAGTAGTTTAACAAAGTTTACCAATAAATATAGTAAGCAACTAACTATAAAGA

ID
ACGAATTGATACCGGTCGGTAAGACTTTGGAAAACATAAAAGAAAATGGGTTGAT

NO:
TGATGGAGACGAGCAATTGAATGAGAATTATCAAAAAGCAAAGATAATAGTAGAT

128
GATTTTTTGAGAGACTTTATTAATAAAGCTCTAAATAACACTCAAATTGGTAACT

GGAGAGAGCTAGCCGACGCCTTGAACAAGGAAGATGAGGATAATATTGAGAAATT

ACAAGATAAGATTAGAGGGATTATCGTGTCTAAGTTTGAGACTTTTGATCTGTTC

AGTTCGTATTCGATTAAAAAGGACGAGAAAATCATCGATGATGATAACGATGTGG

AAGAAGAGGAGCTAGACCTTGGGAAGAAGACATCTAGCTTCAAATACATATTCAA

GAAAAATTTGTTCAAACTTGTCCTTCCTTCATATTTAAAAACAACAAATCAAGAT

AAGTTAAAAATCATTTCTTCCTTCGATAATTTTAGTACTTATTTTCGTGGTTTTT

TCGAAAACAGGAAAAATATATTCACTAAAAAGCCTATATCTACCTCTATAGCTTA

TAGAATTGTTCACGATAATTTCCCAAAATTTCTAGATAATATCAGGTGTTTTAAT

GTTTGGCAAACCGAGTGTCCTCAGTTAATAGTCAAGGCCGACAACTACCTTAAAA

GCAAGAATGTGATTGCAAAAGATAAGTCTTTGGCTAACTATTTTACAGTCGGTGC

CTATGATTATTTTCTGAGTCAAAATGGTATCGATTTCTATAACAACATTATTGGC

GGCTTACCAGCTTTTGCCGGGCATGAGAAGATTCAGGGTTTGAACGAATTTATCA

ATCAAGAATGTCAAAAGGATTCTGAATTAAAGTCTAAGCTCAAGAATAGGCACGC

TTTCAAAATGGCAGTCTTATTCAAACAAATCCTTTCAGACAGAGAAAAGTCATTT

GTGATTGACGAGTTCGAATCAGACGCTCAGGTAATTGATGCTGTTAAAAATTTTT

ACGCGGAACAATGCAAAGATAATAACGTCATATTTAATTTATTGAATCTGATCAA

GAATATTGCTTTTTTGTCGGATGATGAGTTAGACGGCATTTTCATAGAGGGTAAA

TACCTGTCCTCTGTGTCTCAAAAATTGTATAGTGATTGGTCAAAGTTGAGAAATG

ATATTGAAGATTCGGCTAATTCTAAACAGGGTAACAAAGAATTAGCGAAGAAAAT

CAAAACTAACAAGGGTGATGTTGAAAAGGCTATAAGTAAGTACGAGTTCAGTTTA

TCTGAACTAAATTCAATTGTTCATGATAACACAAAATTTTCCGATCTTTTATCAT

GCACATTACATAAAGTTGCAAGTGAAAAATTAGTCAAAGTAAACGAAGGTGATTG

GCCAAAACATCTAAAAAACAACGAGGAAAAACAGAAGATAAAAGAACCTCTTGAC

GCTTTATTGGAAATATACAATACTCTATTAATATTTAACTGTAAAAGTTTTAACA

AAAATGGTAATTTCTATGTCGACTACGATCGCTGCATTAATGAGTTGTCCAGTGT

TGTGTACTTGTATAATAAAACTCGTAATTATTGTACGAAAAAGCCGTACAACACT

GACAAATTTAAGTTGAATTTCAACTCCCCACAACTGGGTGAGGGCTTCTCTAAAA

GTAAAGAGAATGATTGCCTTACATTATTATTTAAAAAAGATGATAATTATTATGT

CGGAATCATAAGAAAGGGGGCAAAGATCAACTTCGATGACACTCAGGCCATAGCA

GACAACACAGATAACTGTATATTCAAAATGAATTATTTTTTGCTGAAGGATGCTA

AAAAATTTATCCCCAAATGTTCAATACAATTAAAAGAGGTTAAGGCCCATTTCAA

AAAGTCGGAAGATGACTATATTTTGTCCGATAAGGAAAAATTCGCTAGTCCGCTT

GTTATTAAAAAATCCACATTTCTTCTCGCTACGGCTCATGTGAAAGGAAAGAAGG

GCAATATTAAGAAATTTCAGAAAGAATACTCCAAAGAAAATCCTACGGAGTATAG

AAATAGTCTGAACGAATGGATAGCATTCTGCAAAGAGTTCTTGAAGACCTATAAA

GCTGCCACCATCTTTGATATTACAACTTTGAAAAAGGCCGAGGAATACGCTGACA

TTGTGGAATTCTATAAGGATGTAGATAATCTTTGTTACAAGTTAGAATTTTGCCC

TATCAAAACTTCTTTTATCGAAAATCTTATAGATAATGGCGATTTATACCTGTTT

AGAATTAATAACAAGGACTTTTCTTCAAAAAGTACAGGCACGAAAAACTTACACA

CATTATACTTGCAGGCTATATTTGACGAGCGAAACTTAAACAACCCCACGATAAT

GTTGAATGGAGGTGCAGAGTTATTCTACAGAAAAGAATCTATAGAACAGAAAAAT

CGGATCACGCACAAAGCCGGTAGTATCTTAGTGAATAAAGTGTGCAAAGATGGTA

CAAGTCTAGATGACAAAATCCGTAACGAAATTTACCAGTATGAAAACAAATTCAT

TGATACTCTTTCGGACGAAGCTAAAAAGGTTCTGCCAAACGTTATTAAGAAAGAG

GCTACGCATGATATAACAAAAGATAAACGTTTCACTAGCGACAAATTCTTCTTTC

ATTGTCCTTTAACAATCAACTACAAGGAAGGTGACACCAAACAATTTAATAATGA

AGTGCTCTCATTCCTTAGAGGTAACCCCGATATCAATATTATCGGCATTGATAGA

GGAGAAAGAAACCTAATCTATGTAACAGTCATTAACCAAAAAGGCGAAATATTGG

ATAGCGTCTCCTTCAATACTGTCACCAATAAGTCATCGAAGATAGAACAAACTGT

TGATTACGAAGAAAAATTGGCCGTTAGAGAAAAGGAACGTATCGAAGCGAAGAGA

TCTTGGGATAGCATATCCAAGATTGCCACCTTGAAGGAGGGTTATCTAAGCGCGA

TCGTACATGAAATCTGCTTATTAATGATTAAGCATAATGCTATTGTCGTGTTAGA

AAACCTGAATGCCGGTTTTAAAAGGATTAGAGGTGGTTTGTCAGAAAAGTCAGTA

TATCAAAAGTTTGAAAAGATGCTTATTAATAAACTCAACTACTTCGTTAGCAAGA

AAGAAAGTGATTGGAATAAACCGTCAGGTTTGCTCAATGGTCTTCAGTTAAGTGA

TCAATTTGAGTCTTTCGAAAAATTAGGAATTCAAAGTGGATTCATTTTTTATGTA

CCAGCCGCGTACACTTCAAAAATTGACCCTACGACCGGATTTGCCAACGTCTTGA

ATTTGTCCAAGGTCAGAAATGTTGACGCCATCAAAAGTTTTTTTAGCAACTTCAA

TGAAATCTCTTATTCCAAAAAGGAAGCCCTTTTCAAGTTTTCTTTTGACCTAGAC

TCGTTATCGAAGAAAGGATTTTCATCTTTCGTAAAGTTTAGCAAGTCCAAGTGGA

ATGTATACACATTCGGCGAGAGAATTATCAAGCCCAAGAACAAACAGGGCTATAG

AGAAGACAAGAGAATCAACTTGACTTTTGAGATGAAAAAATTACTCAACGAATAC

AAGGTTTCATTTGATTTGGAGAACAACTTGATTCCCAATTTGACATCAGCTAACT

TGAAGGATACGTTCTGGAAGGAGTTATTCTTTATATTCAAAACGACATTACAACT

GCGTAATAGTGTTACAAACGGTAAAGAAGATGTATTAATCTCACCTGTAAAGAAT

GCCAAAGGAGAATTTTTCGTATCCGGTACTCACAATAAGACACTACCACAGGATT

GCGACGCTAACGGTGCGTATCATATTGCGTTGAAAGGATTAATGATACTTGAAAG

AAATAACCTTGTTCGCGAAGAAAAAGACACCAAGAAGATCATGGCTATTAGCAAT

GTTGATTGGTTTGAATACGTGCAAAAGAGGAGAGGTGTTTTGTAA

SEQ
ATGAACAATTATGACGAGTTCACAAAGCTATACCCTATCCAAAAAACTATCAGGT

ID
TCGAATTGAAACCACAAGGGAGAACAATGGAACATCTGGAGACATTCAACTTTTT

NO:
TGAAGAGGACAGAGACAGAGCGGAGAAATACAAAATTTTAAAAGAGGCCATCGAT

129
GAATATCACAAAAAGTTTATCGACGAGCATTTAACAAACATGTCTTTGGACTGGA

ATTCACTTAAACAAATTTCTGAGAAATATTATAAGTCTCGGGAGGAAAAAGACAA

AAAGGTCTTTTTGTCCGAGCAAAAGAGAATGAGACAAGAAATTGTCTCGGAGTTT

AAAAAAGATGATCGGTTCAAAGATTTGTTTAGCAAGAAATTGTTTTCTGAATTGT

TGAAGGAGGAGATATACAAGAAAGGCAACCATCAAGAAATAGATGCTTTGAAATC

GTTTGACAAGTTCAGCGGTTACTTCATTGGTTTACATGAAAATAGGAAGAACATG

TATAGCGACGGCGATGAGATCACCGCTATATCGAATAGAATCGTTAACGAAAATT

TTCCGAAATTTTTGGATAATTTGCAAAAATACCAGGAAGCTAGGAAAAAGTACCC

TGAATGGATAATAAAGGCGGAATCAGCTTTGGTGGCTCACAACATAAAGATGGAT

GAAGTCTTCTCGCTGGAATATTTTAACAAAGTATTAAATCAGGAAGGAATCCAAA

GATACAACTTAGCCTTGGGTGGATACGTAACCAAATCAGGTGAGAAAATGATGGG

CTTAAATGATGCACTTAATCTAGCTCACCAATCCGAAAAGTCCTCTAAAGGGAGG

ATACACATGACACCATTGTTTAAGCAAATCCTTTCGGAGAAAGAATCTTTTTCAT

ATATCCCCGATGTTTTCACTGAGGATAGTCAATTGTTGCCCAGCATTGGTGGATT

TTTTGCACAAATAGAAAATGATAAAGATGGTAACATCTTCGATAGAGCCTTGGAA

TTGATAAGCTCCTATGCAGAATACGATACGGAACGAATATACATTAGACAAGCTG

ACATCAACAGAGTAAGCAATGTTATTTTTGGTGAGTGGGGAACTTTAGGTGGATT

AATGCGGGAGTACAAAGCTGACTCAATCAATGATATTAATTTGGAACGTACGTGC

AAAAAAGTCGATAAGTGGCTTGATAGTAAGGAGTTTGCTCTGTCGGATGTACTAG

AAGCAATTAAGAGAACAGGAAACAATGATGCATTTAATGAATATATTAGTAAAAT

GAGGACGGCTAGAGAAAAGATAGACGCCGCACGTAAGGAAATGAAGTTTATTTCC

GAGAAAATATCTGGCGATGAAGAGTCGATTCACATCATCAAGACCCTACTCGATT

CTGTTCAGCAATTTCTCCATTTTTTTAACCTCTTCAAAGCAAGACAAGACATTCC

CTTAGATGGGGCTTTTTATGCCGAATTTGATGAAGTTCATTCAAAGTTGTTTGCT

ATTGTTCCTCTTTACAATAAGGTCCGTAATTACCTTACTAAAAATAACTTGAACA

CCAAGAAAATAAAGTTAAACTTCAAGAATCCGACTCTTGCCAACGGGTGGGATCA

GAATAAAGTTTATGATTATGCTAGCTTAATATTTCTAAGAGATGGGAATTATTAC

TTAGGAATCATCAATCCAAAGCGTAAGAAAAACATTAAATTTGAACAAGGGTCAG

GCAATGGCCCATTCTATAGAAAAATGGTGTATAAGCAAATACCAGGACCTAACAA

GAACTTGCCTCGCGTATTTTTAACTTCAACAAAGGGTAAAAAAGAATATAAACCA

AGCAAAGAAATTATTGAAGGTTACGAAGCAGATAAACACATCAGAGGTGATAAGT

TCGATCTGGATTTCTGCCATAAATTGATTGACTTTTTTAAGGAATCTATAGAAAA

ACATAAGGACTGGTCCAAATTTAATTTCTACTTCTCACCTACAGAAAGTTATGGT

GACATTTCAGAATTTTATTTAGACGTTGAGAAACAAGGATATAGGATGCATTTTG

AAAATATTTCAGCGGAAACCATCGACGAATACGTTGAGAAGGGTGATTTATTCTT

GTTCCAAATTTACAATAAAGACTTCGTTAAAGCTGCAACCGGAAAGAAGGATATG

CATACCATATATTGGAACGCTGCATTCTCGCCAGAAAACTTACAAGATGTCGTTG

TAAAGCTTAATGGAGAAGCTGAGCTGTTCTATAGAGACAAGAGTGATATAAAAGA

GATTGTGCATCGGGAAGGTGAAATTCTGGTGAACAGAACTTACAATGGTCGTACA

CCCGTTCCAGACAAAATACATAAAAAACTGACCGATTATCATAATGGTAGGACAA

AGGACTTGGGCGAGGCCAAGGAGTACCTCGATAAAGTTAGATATTTCAAGGCACA

CTATGATATTACGAAAGACAGGAGATATTTAAACGATAAAATTTACTTTCATGTC

CCTTTGACCCTTAACTTTAAAGCTAATGGTAAAAAGAATTTGAACAAAATGGTAA

TTGAGAAGTTTTTATCGGACGAAAAAGCTCACATAATCGGAATCGACCGCGGAGA

GAGAAATTTACTGTATTATAGTATCATCGACAGAAGTGGAAAGATTATTGATCAG

CAATCTTTGAACGTCATTGATGGGTTTGACTATCGGGAAAAGTTAAATCAAAGGG

AAATTGAAATGAAGGATGCGAGACAATCATGGAATGCCATTGGTAAAATTAAAGA

TCTCAAGGAGGGGTACTTATCAAAAGCTGTACACGAGATAACTAAAATGGCTATC

CAATATAATGCAATTGTTGTAATGGAAGAATTGAATTATGGTTTTAAACGCGGCA

GGTTTAAAGTCGAAAAACAAATATACCAAAAGTTTGAAAACATGTTAATTGATAA

GATGAACTATCTTGTTTTCAAAGATGCACCTGATGAGAGTCCTGGCGGTGTGCTG

AACGCCTATCAATTAACAAACCCATTAGAGTCCTTTGCTAAACTGGGTAAACAAA

CTGGCATTCTATTTTATGTTCCAGCCGCTTACACCTCAAAGATCGATCCAACGAC

CGGTTTTGTAAACTTATTTAATACTTCTTCCAAAACAAACGCGCAAGAACGCAAA

GAATTCCTACAAAAATTTGAATCAATATCCTATAGCGCAAAAGATGGAGGTATAT

TCGCTTTCGCTTTTGACTACAGAAAGTTTGGCACTTCCAAGACAGATCATAAAAA

TGTGTGGACCGCTTATACCAACGGAGAAAGGATGCGTTATATTAAAGAAAAAAAG

AGGAACGAACTATTTGATCCATCGAAAGAAATTAAAGAAGCTTTGACAAGCAGCG

GAATCAAATATGATGGAGGTCAAAACATACTTCCAGATATTCTCAGATCTAATAA

TAACGGTCTTATTTACACGATGTATTCATCTTTTATCGCTGCCATCCAAATGCGT

GTGTATGATGGCAAGGAAGATTATATTATATCTCCTATTAAAAATTCAAAGGGTG

AATTTTTTCGCACGGATCCAAAAAGAAGAGAGCTTCCAATTGACGCCGATGCTAA

CGGTGCTTACAATATTGCATTGCGTGGTGAACTTACTATGAGAGCCATCGCCGAA

AAGTTTGATCCGGACAGTGAAAAAATGGCGAAATTGGAGCTAAAGCACAAGGATT

GGTTTGAATTCATGCAGACCCGTGGCGATTGA

SEQ
ATGACTAAAACGTTCGACTCCGAGTTTTTTAATCTCTATTCCTTGCAAAAGACCG

ID
TTAGGTTTGAATTGAAACCAGTTGGTGAAACTGCCTCATTTGTCGAAGACTTTAA

NO:
AAACGAGGGATTGAAAAGAGTGGTTAGTGAAGATGAAAGAAGGGCAGTAGACTAT

130
CAAAAGGTTAAAGAAATCATTGACGATTACCACAGAGATTTTATAGAAGAATCTC

TGAACTATTTTCCAGAGCAGGTTTCAAAAGATGCTCTAGAGCAAGCGTTTCATTT

GTATCAAAAGTTGAAAGCAGCGAAGGTGGAAGAAAGGGAAAAAGCTTTAAAAGAA

TGGGAAGCATTACAGAAAAAATTGCGAGAAAAAGTCGTCAAATGTTTCAGCGACT

CTAATAAAGCTCGCTTTTCTAGAATCGATAAAAAAGAATTGATTAAGGAAGATTT

AATAAATTGGCTGGTAGCACAAAACAGAGAGGATGATATTCCTACTGTTGAAACG

TTCAATAATTTTACTACTTACTTCACTGGTTTCCATGAGAACAGGAAGAATATTT

ACTCTAAAGATGATCACGCTACTGCTATAAGTTTTAGGTTGATTCACGAAAACTT

GCCTAAATTTTTTGACAATGTCATCAGTTTTAACAAGTTGAAAGAAGGTTTCCCG

GAATTAAAATTCGACAAAGTTAAAGAAGATTTAGAAGTAGATTACGACTTGAAGC

ATGCGTTTGAAATTGAATATTTCGTTAATTTCGTCACACAAGCTGGTATCGACCA

ATATAATTACCTGCTTGGAGGCAAAACTCTAGAAGACGGTACGAAGAAACAAGGA

ATGAATGAACAGATTAATTTATTTAAGCAACAACAAACTCGCGATAAAGCTAGAC

AGATTCCAAAACTGATTCCACTTTTCAAACAGATTCTATCTGAGAGAACTGAATC

TCAGAGTTTTATCCCTAAGCAGTTCGAGTCTGATCAGGAACTATTCGATTCCCTG

CAGAAATTGCATAACAACTGTCAAGATAAGTTTACCGTTTTGCAACAGGCGATCT

TGGGATTGGCTGAGGCAGATCTTAAAAAGGTCTTTATTAAAACTAGTGATCTAAA

CGCATTGTCTAACACTATTTTTGGAAATTATTCTGTGTTCTCAGACGCGCTCAAT

TTATATAAAGAGTCGCTAAAAACTAAAAAGGCTCAAGAAGCTTTTGAAAAGTTGC

CTGCACATAGTATTCATGATTTAATCCAATACTTAGAACAATTTAATTCGTCTCT

CGATGCTGAAAAGCAACAGTCTACCGATACTGTATTAAACTACTTTATTAAAACC

GACGAATTATATAGTCGTTTCATTAAATCCACCTCTGAGGCATTCACCCAAGTAC

AACCTCTCTTTGAACTGGAAGCTTTGAGCTCCAAAAGAAGACCCCCAGAAAGTGA

AGATGAGGGGGCTAAAGGCCAAGAAGGTTTCGAACAAATTAAGAGAATCAAAGCT

TATCTAGACACTCTAATGGAGGCTGTCCACTTTGCTAAGCCTTTGTATCTTGTCA

AGGGTAGAAAGATGATAGAGGGTCTAGACAAGGATCAAAGCTTCTACGAAGCGTT

TGAAATGGCCTACCAGGAGTTGGAGTCTTTAATCATCCCCATTTACAATAAGGCC

AGATCTTACCTGTCTAGGAAGCCATTTAAAGCGGATAAATTCAAAATTAATTTTG

ACAATAATACACTTCTATCTGGGTGGGATGCTAACAAGGAGACGGCTAACGCCAG

CATATTGTTTAAGAAGGATGGTTTATACTACCTGGGAATCATGCCAAAAGGCAAA

ACTTTCTTGTTCGATTATTTCGTTAGTTCAGAAGATTCTGAAAAGTTGAAACAAC

GGAGACAGAAAACCGCAGAGGAAGCGCTCGCACAGGATGGAGAATCCTATTTTGA

AAAAATACGGTATAAACTCCTACCAGGTGCTAGTAAGATGTTGCCAAAGGTATTT

TTTAGCAATAAAAATATTGGGTTTTACAATCCCTCAGATGATATTCTACGAATTC

GGAATACGGCCTCTCATACTAAGAATGGTACTCCCCAGAAGGGTCATTCCAAGGT

AGAATTTAACTTGAATGACTGTCACAAAATGATTGATTTTTTTAAATCTTCCATA

CAGAAACATCCCGAGTGGGGATCCTTTGGTTTCACTTTTTCTGATACGTCGGACT

TTGAAGATATGAGTGCTTTCTACCGAGAAGTTGAAAATCAAGGTTACGTTATAAG

TTTTGATAAAATAAAAGAAACTTACATTCAGTCTCAAGTTGAGCAAGGTAACTTA

TATTTATTTCAAATTTACAACAAAGATTTTAGTCCGTATTCAAAGGGAAAGCCAA

ACCTGCACACTTTATACTGGAAAGCTCTGTTTGAAGAGGCTAATTTGAATAACGT

AGTGGCTAAGCTAAACGGCGAAGCAGAAATCTTTTTCAGAAGACACAGTATCAAA

GCATCTGATAAAGTGGTACATCCTGCTAATCAAGCTATAGATAATAAGAATCCCC

ATACTGAGAAGACGCAGTCCACATTTGAATATGACTTGGTCAAAGACAAAAGATA

TACCCAAGACAAATTTTTTTTTCATGTACCGATATCTTTAAACTTTAAGGCTCAG

GGCGTTTCAAAGTTTAATGATAAGGTAAATGGATTCTTAAAGGGCAATCCCGACG

TTAATATAATCGGTATAGATCGAGGTGAGAGACATCTTTTATACTTTACCGTGGT

GAATCAAAAAGGAGAAATATTAGTGCAAGAGTCCTTGAATACATTAATGTCTGAC

AAGGGTCATGTCAACGATTATCAACAGAAATTGGACAAGAAGGAACAGGAAAGGG

ACGCTGCCAGGAAGTCCTGGACGACAGTAGAAAATATTAAAGAATTAAAAGAAGG

TTATTTATCACATGTGGTTCATAAACTTGCACATTTAATCATCAAATATAACGCA

ATAGTGTGCTTGGAAGATCTTAATTTTGGCTTCAAGAGGGGTAGGTTCAAGGTCG

AAAAACAGGTCTACCAGAAGTTCGAGAAAGCTCTGATCGATAAATTGAATTATCT

TGTTTTCAAAGAAAAAGAATTAGGAGAAGTTGGTCATTATCTTACAGCATACCAA

CTCACTGCACCATTTGAAAGCTTCAAAAAGCTAGGCAAGCAATCTGGGATTTTGT

TCTATGTTCCGGCTGATTATACATCAAAGATAGATCCTACCACAGGCTTTGTAAA

TTTTTTAGATCTTAGGTACCAATCCGTTGAAAAAGCTAAACAGTTGCTGTCCGAT

TTTAATGCGATAAGATTTAATAGTGTTCAGAATTATTTTGAGTTCGAAATTGATT

ATAAAAAATTGACACCAAAACGTAAAGTAGGAACACAATCTAAATGGGTTATTTG

TACCTATGGAGATGTTAGATACCAAAACAGAAGAAATCAGAAAGGTCACTGGGAA

ACTGAAGAAGTTAACGTTACTGAAAAACTTAAAGCTCTATTTGCGAGCGATTCAA

AAACGACGACGGTGATCGATTATGCAAATGATGATAACCTTATTGATGTAATTCT

GGAACAAGATAAGGCATCATTTTTTAAAGAACTACTATGGTTGTTAAAGCTAACC

ATGACCCTAAGGCACTCCAAGATAAAGTCAGAGGATGATTTTATCCTCTCTCCAG

TGAAAAACGAACAAGGTGAGTTTTACGACTCAAGAAAGGCGGGTGAAGTCTGGCC

TAAGGATGCTGATGCCAATGGAGCTTATCACATCGCTCTGAAGGGGCTATGGAAC

TTACAGCAAATTAACCAATGGGAAAAAGGTAAAACTTTAAACCTCGCCATAAAGA

ACCAGGATTGGTTCAGCTTTATCCAAGAAAAACCATATCAAGAATAA

SEQ
ATGCACACAGGAGGTCTACTCTCGATGGATGCTAAGGAATTTACCGGTCAATATC

ID
CGCTGTCCAAAACTTTGCGTTTTGAGCTTAGACCTATTGGCCGAACGTGGGATAA

NO:
CCTAGAGGCTTCTGGTTATTTGGCGGAAGATAGACATAGAGCTGAGTGTTATCCC

131
CGAGCTAAAGAATTGCTGGATGATAACCACAGGGCGTTCCTGAATAGAGTTCTAC

CGCAAATCGATATGGATTGGCATCCAATTGCTGAAGCTTTCTGCAAGGTGCACAA

AAATCCAGGTAATAAAGAATTGGCTCAGGATTATAATTTGCAGCTTAGTAAGAGA

AGAAAAGAAATTTCCGCTTATTTGCAGGATGCTGATGGATACAAGGGGTTGTTCG

CGAAACCTGCCCTGGACGAAGCTATGAAAATAGCTAAGGAAAACGGCAATGAATC

TGATATTGAAGTTTTGGAAGCCTTCAATGGATTTTCCGTTTATTTCACTGGTTAT

CATGAGAGTAGGGAGAATATATACTCAGACGAAGATATGGTATCCGTCGCCTATC

GCATAACTGAAGATAATTTTCCAAGGTTCGTGTCGAACGCGTTAATTTTTGATAA

ACTAAATGAATCGCACCCGGATATTATTTCGGAAGTGTCCGGTAATCTGGGGGTA

GACGATATTGGTAAATATTTTGATGTGTCCAACTACAATAATTTCCTTAGTCAAG

CAGGAATTGATGACTACAACCATATTATAGGAGGGCATACAACTGAAGACGGTCT

CATTCAAGCTTTTAACGTAGTGTTAAACCTAAGGCACCAAAAAGACCCAGGTTTT

GAGAAAATTCAATTTAAGCAACTCTACAAGCAGATACTGAGCGTTAGGACTAGTA

AGTCATATATCCCAAAGCAATTCGATAACTCAAAGGAAATGGTCGACTGTATATG

CGACTACGTCTCAAAAATAGAAAAATCTGAAACAGTAGAAAGAGCTCTGAAATTG

GTAAGAAATATATCTTCTTTTGATTTAAGAGGTATTTTCGTAAATAAAAAAAACC

TTCGAATTTTGTCTAATAAGTTAATTGGAGACTGGGACGCAATAGAGACAGCTTT

GATGCACAGTTCCAGCAGTGAAAACGATAAGAAATCAGTGTATGACTCTGCAGAG

GCATTCACCCTTGATGATATCTTCAGTTCTGTGAAAAAGTTCAGCGACGCCTCCG

CTGAGGATATAGGAAACCGCGCTGAAGACATATGTCGTGTTATCTCAGAAACAGC

TCCTTTCATTAACGACTTAAGGGCTGTAGATTTGGATTCTTTAAATGATGACGGC

TATGAAGCGGCCGTGTCTAAAATACGGGAATCTCTTGAACCCTACATGGATCTAT

TTCACGAATTGGAGATCTTTAGCGTGGGTGATGAGTTTCCTAAATGTGCTGCCTT

TTATAGCGAGTTGGAAGAGGTCTCAGAACAACTGATTGAAATCATTCCTTTATTT

AACAAAGCAAGAAGTTTTTGCACAAGGAAAAGGTATTCAACCGACAAAATCAAAG

TCAATTTAAAATTCCCTACTCTGGCAGATGGATGGGATCTAAATAAAGAAAGGGA

TAACAAAGCCGCAATTCTAAGAAAAGACGGTAAATACTACCTGGCAATTTTAGAC

ATGAAGAAAGATCTCAGTAGTATTCGTACGAGCGATGAGGACGAGTCTTCTTTTG

AAAAGATGGAATATAAATTGCTCCCTTCTCCTGTGAAAATGCTTCCAAAAATTTT

TGTTAAATCGAAAGCCGCCAAAGAAAAGTACGGGTTGACCGATAGAATGTTAGAA

TGCTACGATAAAGGTATGCATAAGTCGGGTAGTGCTTTTGATTTGGGTTTTTGTC

ATGAATTGATCGATTACTATAAGCGCTGCATTGCCGAGTACCCAGGCTGGGATGT

TTTCGACTTTAAATTTCGTGAGACAAGCGATTACGGATCCATGAAAGAATTTAAT

GAAGACGTCGCTGGCGCAGGTTACTATATGTCACTTAGAAAGATTCCATGTTCCG

AAGTTTATCGTTTACTGGACGAGAAGTCAATTTACTTGTTTCAAATATATAATAA

GGATTATAGCGAAAACGCACATGGGAATAAGAATATGCATACGATGTATTGGGAG

GGCTTGTTCTCACCACAAAATTTGGAATCACCAGTCTTCAAATTGTCCGGAGGCG

CAGAACTTTTTTTCAGAAAGTCATCTATTCCTAATGACGCTAAAACGGTACATCC

GAAAGGTTCAGTTCTTGTTCCCAGAAACGACGTCAATGGTAGAAGAATACCAGAC

TCGATCTACAGAGAGTTGACAAGGTATTTTAACCGTGGGGATTGCAGGATCAGTG

ATGAAGCTAAGTCTTACCTGGACAAGGTCAAGACAAAAAAAGCGGACCATGACAT

TGTTAAGGATAGAAGATTTACTGTAGATAAGATGATGTTCCATGTTCCGATTGCC

ATGAATTTTAAAGCTATAAGTAAACCAAATCTTAATAAGAAAGTTATTGATGGCA

TAATAGATGATCAAGATTTGAAAATCATCGGTATCGATCGTGGTGAGAGAAATCT

TATTTATGTGACCATGGTCGATAGGAAGGGGAATATATTGTATCAAGACAGTCTT

AATATTTTAAATGGATACGATTACCGCAAAGCTTTAGACGTGAGGGAATATGATA

ACAAAGAAGCTAGAAGGAATTGGACTAAAGTAGAAGGTATTAGAAAAATGAAAGA

AGGTTATTTATCTTTAGCTGTTAGTAAATTGGCCGATATGATCATCGAAAATAAT

GCTATAATCGTAATGGAAGATTTGAATCACGGGTTTAAGGCAGGTCGTTCCAAAA

TTGAAAAGCAGGTGTATCAAAAATTCGAATCAATGTTAATCAACAAGTTAGGATA

CATGGTGCTAAAAGACAAGTCCATTGACCAGTCTGGTGGAGCCCTTCATGGTTAC

CAATTAGCCAATCATGTTACGACCTTAGCTAGCGTGGGTAAACAATGTGGAGTAA

TTTTTTACATACCTGCAGCTTTTACTTCGAAGATTGATCCCACCACGGGCTTTGC

TGATTTATTCGCTCTCTCTAATGTGAAGAATGTCGCTTCTATGAGAGAGTTCTTC

TCCAAAATGAAGTCAGTAATATATGACAAGGCGGAAGGCAAATTCGCCTTTACAT

TTGATTATTTGGATTATAACGTTAAAAGCGAATGTGGACGTACCTTATGGACTGT

GTATACAGTTGGTGAACGCTTCACCTACTCTAGAGTAAACCGAGAGTATGTTCGG

AAAGTCCCAACAGATATCATCTATGATGCATTACAAAAAGCTGGTATTAGCGTCG

AAGGTGACCTTAGAGATAGAATCGCGGAAAGCGACGGTGACACATTAAAGTCTAT

ATTCTACGCTTTTAAATACGCGTTGGATATGAGAGTCGAAAACAGAGAGGAAGAC

TATATACAGTCACCTGTGAAGAATGCTTCTGGTGAGTTCTTTTGTTCAAAAAACG

CCGGAAAGTCTTTGCCGCAGGATTCAGATGCAAATGGTGCCTATAATATAGCTCT

GAAAGGGATCCTACAACTCAGAATGTTGAGCGAACAATACGATCCAAATGCAGAA

TCGATTAGATTGCCACTTATAACTAACAAGGCATGGTTAACTTTTATGCAATCCG

GTATGAAAACTTGGAAGAATTAA

SEQ
ATGGATTCTCTTAAGGATTTCACTAATTTATATCCAGTCTCGAAAACATTGCGGT

ID
TCGAATTGAAACCAGTTGGGAAAACTCTAGAAAACATTGAAAAAGCCGGTATATT

NO:
GAAAGAAGATGAACACAGAGCGGAATCCTACCGCCGGGTAAAAAAGATAATTGAC

132
ACATACCATAAAGTGTTTATTGACAGCTCCTTAGAGAACATGGCTAAAATGGGGA

TAGAAAATGAAATCAAGGCTATGCTGCAGTCTTTTTGTGAACTCTATAAGAAAGA

CCACAGGACAGAAGGAGAAGATAAAGCTCTTGATAAAATTAGAGCTGTTCTTAGA

GGTTTAATCGTTGGGGCTTTCACTGGTGTATGTGGAAGACGAGAAAACACAGTAC

AAAATGAAAAGTACGAGAGTTTGTTCAAAGAAAAATTGATAAAGGAAATTTTGCC

AGATTTCGTGTTGTCCACCGAGGCTGAGTCTCTTCCATTCAGCGTTGAAGAAGCA

ACAAGGAGCTTAAAAGAGTTTGACTCATTCACTTCTTATTTTGCTGGTTTTTACG

AAAATAGAAAGAATATTTATTCCACGAAACCGCAAAGTACTGCGATAGCCTACAG

ATTAATTCATGAAAACTTGCCTAAATTTATAGATAATATTTTGGTCTTCCAGAAG

ATTAAAGAACCAATCGCTAAAGAACTTGAGCACATAAGAGCAGATTTTAGCGCAG

GCGGATATATCAAAAAAGATGAACGGCTAGAAGACATATTCTCATTAAATTACTA

CATTCATGTCCTTTCTCAAGCTGGTATAGAAAAATATAATGCTTTAATCGGGAAG

ATAGTGACGGAAGGTGATGGTGAAATGAAAGGTCTTAATGAACATATTAACTTAT

ATAACCAACAGAGGGGTCGAGAGGATAGGTTGCCCTTGTTTAGGCCTCTATACAA

GCAAATCCTGTCCGATAGAGAGCAATTGTCTTATTTACCTGAATCATTTGAAAAA

GATGAAGAGCTGCTTAGAGCACTTAAGGAATTTTACGATCACATCGCCGAAGACA

TCTTGGGTAGAACACAGCAATTGATGACTTCAATTTCTGAATACGACTTGTCCCG

TATTTATGTCAGAAATGATTCTCAACTTACAGACATCTCGAAGAAAATGCTAGGA

GATTGGAACGCCATTTATATGGCTAGAGAACGAGCCTACGACCACGAACAGGCTC

CTAAACGTATTACTGCTAAATACGAACGTGATAGAATCAAGGCCTTAAAAGGTGA

AGAGTCAATTTCATTGGCGAATCTGAACAGCTGTATAGCTTTCTTGGACAATGTA

AGGGATTGTCGAGTTGACACATACCTATCAACTTTGGGGCAGAAAGAGGGTCCTC

ATGGCTTAAGTAACTTGGTGGAAAACGTCTTCGCCTCATATCATGAAGCAGAACA

GTTATTGTCGTTTCCTTACCCCGAAGAGAACAACCTTATTCAGGACAAAGACAAT

GTAGTTTTGATCAAAAACCTATTGGATAATATAAGTGATTTACAACGTTTCCTTA

AACCTTTGTGGGGAATGGGCGATGAACCTGACAAAGACGAAAGGTTTTACGGTGA

ATACAACTATATTAGAGGAGCGCTTGACCAGGTAATACCTTTGTACAATAAAGTA

AGGAACTACTTGACTCGTAAACCATATTCTACTAGAAAAGTTAAATTGAACTTTG

GTAATTCACAGCTGCTGAGTGGTTGGGATCGTAATAAAGAAAAAGATAACTCCTG

TGTTATCTTGCGAAAAGGACAAAACTTTTACTTGGCAATTATGAACAACCGTCAC

AAAAGGTCCTTCGAGAACAAAGTTCTGCCTGAATACAAAGAAGGTGAACCATATT

TTGAAAAAATGGACTATAAATTCCTGCCAGATCCTAATAAAATGTTGCCTAAGGT

CTTCTTGTCTAAAAAAGGTATAGAAATATATAAACCATCCCCGAAGTTGCTGGAG

CAATATGGTCATGGAACGCACAAAAAAGGTGACACTTTTAGTATGGATGACTTGC

ACGAGTTGATTGATTTTTTTAAACATTCCATTGAAGCGCACGAAGATTGGAAACA

ATTTGGTTTCAAGTTCTCTGACACAGCCACTTACGAAAATGTATCGTCCTTTTAT

AGAGAAGTGGAAGATCAGGGTTATAAACTGTCATTCCGTAAGGTTAGTGAAAGCT

ATGTGTACTCGTTGATCGATCAAGGGAAGCTTTATCTTTTTCAAATCTATAATAA

AGATTTCTCTCCTTGTTCAAAGGGCACACCTAATCTTCATACACTATACTGGAGA

ATGCTTTTCGATGAAAGAAATTTGGCTGATGTGATCTATAAATTAGACGGTAAAG

CTGAGATTTTTTTCAGAGAGAAATCCCTGAAAAACGACCATCCAACTCATCCGGC

AGGTAAACCGATTAAAAAGAAATCCCGGCAAAAAAAGGGCGAAGAGAGTTTATTC

GAGTATGATTTAGTTAAGGACAGACATTATACAATGGACAAATTTCAATTTCATG

TGCCCATTACTATGAACTTTAAGTGTAGTGCAGGGTCTAAGGTTAATGATATGGT

AAACGCACATATTAGAGAAGCTAAAGATATGCACGTCATCGGTATTGATCGCGGA

GAAAGAAATTTACTTTACATTTGCGTTATCGATTCTAGGGGCACCATCTTGGATC

AAATCTCTTTGAACACTATAAATGATATTGACTATCATGATCTACTAGAGAGTCG

GGATAAAGACAGGCAACAAGAAAGAAGAAATTGGCAAACAATTGAAGGTATTAAA

GAATTAAAGCAAGGCTATCTAAGCCAGGCTGTACACAGAATTGCCGAATTAATGG

TAGCATATAAAGCTGTCGTAGCTCTAGAAGACTTGAACATGGGTTTCAAAAGAGG

GCGCCAGAAGGTCGAAAGTAGTGTTTATCAACAATTTGAAAAACAGTTAATAGAT

AAGTTGAATTATCTAGTGGATAAAAAAAAGCGTCCTGAGGACATTGGCGGTTTAT

TAAGAGCCTACCAATTCACTGCGCCATTTAAATCGTTCAAAGAAATGGGTAAACA

AAACGGTTTTCTATTCTACATCCCCGCATGGAATACCTCAAATATAGATCCAACT

ACCGGTTTCGTCAACTTATTTCATGCTCAATATGAGAATGTGGACAAAGCAAAAT

CATTCTTTCAAAAATTTGATAGCATTAGCTACAATCCTAAAAAAGATTGGTTTGA

ATTTGCGTTCGATTATAAAAATTTCACCAAGAAGGCTGAAGGTTCCAGATCTATG

TGGATATTGTGCACCCACGGAAGTAGAATTAAGAACTTCCGTAATTCACAGAAAA

ACGGCCAGTGGGACAGCGAAGAATTCGCCCTAACCGAAGCTTTCAAAAGTCTTTT

CGTAAGATACGAGATAGACTATACAGCTGATCTAAAGACAGCTATTGTGGATGAG

AAGCAAAAAGACTTCTTTGTCGACCTTCTTAAGTTGTTCAAGTTAACTGTGCAGA

TGAGAAATAGTTGGAAGGAAAAAGACCTAGATTACTTGATTAGCCCAGTCGCTGG

TGCAGATGGCAGATTTTTTGATACACGTGAAGGCAATAAATCACTACCAAAAGAC

GCGGACGCTAATGGCGCATACAACATCGCATTGAAGGGTTTGTGGGCTCTCAGGC

AGATTAGGCAGACAAGTGAGGGTGGTAAGCTTAAGCTGGCGATTTCTAATAAGGA

ATGGTTACAGTTTGTTCAAGAAAGATCCTACGAAAAAGATTAA

SEQ
ATGAACAATGGTACTAATAATTTTCAAAACTTCATAGGGATTTCTAGCCTTCAAA

ID
AGACATTGAGAAATGCTTTAATTCCAACAGAAACGACTCAACAATTCATAGTGAA

NO:
AAATGGTATTATAAAAGAAGACGAGTTGCGTGGCGAGAATAGACAAATTTTGAAA

133
GATATCATGGATGACTACTACAGAGGGTTCATCTCCGAAACATTGTCTTCTATTG

ACGACATTGACTGGACCAGCTTATTCGAAAAAATGGAAATACAGCTGAAGAACGG

AGATAACAAGGACACTCTTATAAAGGAGCAAACGGAATATAGAAAGGCTATACAC

AAAAAGTTTGCTAATGACGATAGATTTAAAAACATGTTTAGTGCGAAGTTAATTT

CTGATATTCTACCCGAGTTTGTCATTCATAATAATAACTACTCTGCATCTGAAAA

AGAGGAGAAGACCCAGGTTATAAAGTTGTTTTCAAGATTTGCCACATCATTTAAA

GACTACTTCAAGAACAGGGCGAATTGCTTCTCTGCTGATGATATTAGCTCTTCCA

GCTGTCATAGAATTGTTAACGATAATGCCGAAATTTTTTTTAGTAATGCCTTGGT

ATATAGACGCATAGTCAAGTCACTAAGCAATGATGATATAAACAAGATTAGTGGT

GATATGAAAGATAGCCTTAAAGAAATGAGCCTTGAAGAGATATATTCATATGAGA

AGTACGGTGAATTTATAACTCAAGAAGGAATTTCTTTTTATAACGATATTTGTGG

TAAGGTTAATTCTTTTATGAATTTGTATTGCCAGAAGAACAAGGAAAATAAGAAT

CTATATAAACTACAAAAGTTGCATAAACAGATTTTGTGTATAGCTGATACATCCT

ACGAAGTTCCGTATAAATTTGAATCTGATGAGGAAGTTTATCAATCGGTAAACGG

TTTTCTTGACAACATTTCCAGCAAACATATCGTTGAGAGACTACGTAAAATTGGA

GACAACTATAATGGTTACAATCTAGATAAAATATACATAGTGTCCAAGTTTTATG

AGTCTGTCTCTCAAAAGACATATCGTGATTGGGAGACCATTAATACTGCACTTGA

AATTCATTATAACAACATATTGCCTGGTAACGGGAAGAGTAAAGCTGATAAGGTT

AAAAAGGCCGTCAAAAACGACTTGCAAAAGTCTATTACCGAGATAAATGAATTAG

TGTCAAACTACAAACTATGCTCAGATGATAATATTAAAGCGGAAACATACATCCA

CGAAATTTCCCACATACTGAATAACTTTGAAGCTCAGGAGCTTAAATATAACCCG

GAAATACACTTGGTTGAGAGCGAGTTAAAAGCATCTGAGTTGAAAAATGTATTAG

ACGTCATCATGAATGCGTTTCATTGGTGTTCAGTTTTCATGACTGAAGAATTAGT

CGACAAAGATAACAATTTTTATGCCGAATTAGAGGAAATATATGATGAAATTTAT

CCCGTAATTAGTTTATACAATCTAGTTAGAAATTATGTTACACAAAAGCCGTATA

GTACCAAGAAAATAAAGCTTAATTTCGGAATACCTACGCTTGCTGATGGTTGGTC

AAAAAGTAAAGAATATAGCAATAATGCAATAATTTTAATGAGAGATAACCTATAT

TATTTGGGTATTTTTAACGCTAAGAACAAACCAGACAAGAAAATAATTGAAGGTA

ATACATCTGAAAACAAGGGCGACTATAAAAAGATGATATACAATTTGCTCCCAGG

TCCTAATAAAATGATTCCTAAGGTTTTCCTGAGTAGCAAGACTGGCGTTGAAACT

TACAAGCCTAGTGCGTATATCCTGGAGGGTTATAAACAGAACAAGCATATCAAAT

CCTCTAAGGACTTCGATATCACCTTTTGCCATGACTTAATCGATTATTTTAAAAA

TTGTATCGCAATTCATCCAGAATGGAAAAATTTCGGATTTGATTTTAGTGATACC

AGCACTTACGAGGATATCTCTGGGTTCTACAGAGAAGTGGAGTTGCAGGGCTACA

AAATCGATTGGACTTACATATCTGAAAAGGACATAGATTTGCTGCAGGAGAAAGG

TCAGCTATATTTGTTTCAAATCTACAACAAAGACTTTTCTAAAAAGTCTACCGGT

AATGACAATCTGCACACAATGTACTTGAAGAACTTATTCTCCGAGGAGAACTTAA

AGGACATTGTACTCAAGTTGAATGGAGAAGCCGAGATTTTTTTTAGAAAGAGCAG

TATAAAGAATCCTATAATCCACAAGAAGGGCTCAATTCTCGTGAATAGGACGTAT

GAGGCAGAAGAAAAGGACCAATTTGGGAATATACAAATTGTAAGAAAAAACATCC

CAGAAAATATCTACCAGGAATTATATAAGTATTTTAATGACAAATCTGATAAGGA

ACTGTCTGACGAAGCCGCTAAGCTCAAGAATGTTGTGGGCCACCATGAAGCTGCT

ACTAATATAGTGAAGGACTACAGATATACCTACGATAAATATTTCCTGCATATGC

CAATTACTATAAACTTCAAAGCAAATAAAACAGGTTTTATAAATGATAGAATCCT

GCAGTATATTGCTAAAGAAAAGGATTTACATGTAATTGGGATTGATAGAGGTGAA

CGCAATCTGATCTATGTCAGCGTAATAGATACTTGTGGTAATATTGTGGAACAAA

AGTCCTTTAATATTGTGAACGGATATGATTACCAAATCAAGTTGAAACAACAAGA

GGGAGCACGCCAAATTGCCCGTAAGGAATGGAAAGAGATAGGTAAGATCAAGGAA

ATTAAGGAAGGTTATCTTTCATTAGTTATTCACGAAATTTCGAAGATGGTAATCA

AATACAACGCAATAATTGCTATGGAGGACCTGTCATATGGATTTAAGAAAGGTAG

ATTCAAGGTTGAGAGACAGGTATACCAGAAATTTGAAACTATGTTGATCAACAAA

TTAAATTACTTAGTCTTTAAGGACATATCAATAACGGAAAACGGCGGGCTTTTAA

AAGGGTATCAACTTACATACATACCTGATAAGTTGAAAAATGTGGGTCATCAGTG

TGGGTGCATCTTTTATGTTCCAGCCGCTTACACATCAAAAATCGATCCTACTACT

GGGTTCGTAAACATATTTAAATTTAAAGATCTAACCGTTGATGCAAAAAGAGAGT

TTATCAAGAAATTTGATAGCATTAGGTACGATTCAGAAAAAAATCTATTCTGTTT

TACTTTTGACTACAACAACTTTATAACGCAGAATACAGTGATGTCAAAATCGTCC

TGGTCAGTGTATACTTATGGTGTTAGAATTAAGAGACGTTTCGTAAACGGTCGTT

TTTCTAACGAGTCCGATACAATCGACATCACTAAAGATATGGAAAAAACTTTGGA

AATGACAGATATAAACTGGAGAGATGGTCACGACCTTAGACAAGATATAATCGAT

TATGAAATCGTACAGCATATTTTTGAAATTTTTCGCTTAACAGTTCAGATGCGTA

ACTCTCTTAGTGAGCTAGAAGATAGAGATTATGATAGACTTATCTCGCCTGTTCT

TAACGAAAATAATATCTTCTATGACTCGGCAAAAGCCGGTGATGCACTTCCAAAA

GATGCTGATGCAAATGGCGCGTACTGCATCGCATTGAAGGGGCTCTACGAGATTA

AACAAATCACCGAAAACTGGAAAGAAGATGGTAAATTTTCTAGGGATAAGTTGAA

AATCAGTAATAAAGATTGGTTCGATTTTATACAAAATAAGCGATACTTATAG

SEQ
ATGACCAATAAGTTTACTAATCAATACTCATTGTCTAAAACGTTAAGATTCGAGT

ID
TAATTCCCCAGGGAAAGACACTAGAATTTATTCAAGAAAAAGGTCTTCTCTCTCA

NO:
GGATAAACAAAGAGCAGAATCATACCAGGAGATGAAAAAAACCATAGATAAATTT

134
CATAAGTACTTCATCGACTTGGCACTATCGAACGCCAAGCTAACACATTTGGAAA

CCTACCTGGAGTTGTATAATAAATCGGCAGAGACGAAAAAGGAACAAAAATTCAA

GGATGACCTGAAGAAGGTTCAAGATAATCTGCGAAAGGAAATAGTGAAGTCGTTT

AGTGATGGTGATGCAAAGTCAATCTTTGCTATTTTAGACAAGAAGGAATTAATAA

CCGTGGAACTTGAAAAGTGGTTTGAAAATAACGAACAGAAAGATATTTACTTCGA

CGAAAAATTTAAAACGTTTACTACGTACTTTACAGGGTTCCATCAGAACCGCAAA

AACATGTACTCCGTTGAACCAAACTCTACTGCAATCGCCTACAGATTAATACACG

AAAATTTGCCTAAGTTTTTAGAAAATGCAAAGGCTTTTGAAAAGATAAAGCAAGT

CGAATCGTTACAGGTAAACTTTCGCGAATTAATGGGCGAATTTGGAGATGAAGGT

CTTATTTTTGTCAATGAATTAGAGGAAATGTTTCAAATTAATTATTATAACGATG

TCTTGAGTCAGAACGGCATTACTATCTACAACTCAATTATCAGTGGTTTCACTAA

GAATGATATAAAATATAAAGGTTTGAATGAATACATTAATAATTATAATCAAACT

AAAGATAAGAAGGACAGGCTTCCGAAATTGAAGCAATTGTACAAGCAGATTCTAA

GTGATAGGATTAGTTTGTCTTTCTTGCCAGACGCATTTACTGATGGCAAGCAAGT

CTTAAAGGCTATATTCGATTTCTACAAGATTAACCTACTTTCGTACACAATTGAA

GGTCAAGAAGAATCTCAAAATCTGCTGCTTTTGATTAGGCAAACTATAGAAAATT

TGTCGTCCTTTGACACTCAAAAAATTTACCTGAAGAATGATACACACCTGACTAC

AATATCACAGCAGGTCTTTGGGGATTTTTCTGTCTTCTCCACGGCCCTAAACTAT

TGGTATGAGACAAAAGTTAATCCAAAATTTGAAACAGAATATAGTAAGGCGAATG

AAAAAAAGAGAGAAATTTTGGATAAAGCGAAGGCAGTATTCACAAAACAAGACTA

TTTTTCTATCGCATTTCTCCAAGAAGTCTTATCCGAATATATTTTGACACTCGAT

CACACCTCTGATATAGTTAAGAAACATTCGTCCAACTGCATCGCAGATTACTTCA

AGAATCACTTCGTGGCTAAGAAAGAAAACGAAACGGATAAAACTTTTGACTTCAT

TGCTAACATAACCGCTAAATACCAATGTATTCAGGGCATATTAGAAAATGCAGAC

CAGTACGAAGACGAGTTAAAACAGGACCAAAAGTTAATAGATAATCTAAAGTTTT

TCTTAGATGCTATACTTGAGTTATTACATTTTATAAAGCCATTGCATCTAAAATC

GGAAAGTATTACTGAAAAAGACACTGCGTTCTATGATGTGTTCGAAAATTATTAT

GAGGCTTTATCTTTATTGACCCCCCTTTACAACATGGTCCGCAATTATGTTACTC

AGAAGCCTTACTCTACTGAAAAGATCAAATTAAACTTTGAAAATGCTCAGTTGCT

GAATGGTTGGGATGCCAATAAGGAAGGTGACTACCTGACGACTATTCTAAAAAAA

GACGGTAATTATTTCTTAGCAATCATGGATAAAAAACATAACAAGGCATTTCAAA

AATTTCCAGAAGGAAAAGAAAACTATGAAAAGATGGTTTATAAATTGTTGCCTGG

AGTTAATAAAATGTTGCCAAAAGTTTTTTTTAGCAATAAGAACATAGCTTACTTT

AATCCATCTAAGGAACTGCTCGAGAACTACAAGAAGGAAACACATAAAAAAGGTG

ATACATTTAATTTGGAACATTGCCATACTCTGATTGATTTTTTTAAGGACTCTCT

TAATAAACATGAAGACTGGAAATATTTTGATTTTCAATTTTCGGAAACTAAATCA

TACCAAGATCTAAGTGGATTTTACAGAGAAGTTGAACACCAAGGTTATAAGATTA

ACTTCAAGAATATAGATTCTGAATACATTGATGGTCTTGTAAACGAGGGTAAACT

ATTCCTGTTCCAAATCTACTCTAAGGACTTCTCACCTTTTTCCAAAGGAAAACCT

AATATGCATACGTTGTACTGGAAGGCTCTATTTGAAGAACAAAATTTGCAAAATG

TAATCTACAAACTGAACGGCCAAGCTGAAATATTCTTCAGAAAAGCCTCAATTAA

GCCAAAAAACATTATTCTTCATAAAAAGAAGATCAAGATTGCGAAGAAACATTTT

ATTGATAAGAAGACCAAGACTTCCGAAATTGTACCAGTACAAACAATCAAGAATC

TCAATATGTATTATCAAGGCAAGATAAGTGAGAAAGAGTTAACCCAGGATGATTT

ACGTTATATAGACAATTTCTCTATATTCAACGAGAAGAACAAAACAATAGACATT

ATCAAAGATAAAAGGTTTACTGTTGACAAATTTCAATTTCATGTGCCTATCACAA

TGAACTTTAAGGCCACAGGTGGTTCGTACATTAATCAAACTGTTTTAGAATATCT

GCAAAATAACCCAGAGGTCAAGATCATCGGTCTTGATAGGGGTGAGAGACATCTG

GTGTATCTAACACTCATTGATCAACAAGGCAACATCTTGAAGCAAGAATCATTGA

ACACTATCACAGACTCCAAGATCTCGACTCCATATCACAAACTCCTTGACAATAA

AGAAAACGAAAGGGATCTTGCCAGAAAAAATTGGGGTACAGTTGAAAATATTAAG

GAACTAAAAGAAGGTTACATTTCGCAAGTAGTTCACAAGATTGCAACACTCATGT

TGGAAGAAAACGCAATCGTTGTCATGGAAGATTTAAATTTCGGATTTAAGAGAGG

AAGATTTAAAGTAGAAAAGCAAATCTACCAGAAGTTGGAGAAGATGTTAATTGAC

AAATTGAACTACTTAGTGCTGAAAGACAAACAGCCTCAAGAATTGGGCGGTCTAT

ACAACGCTTTACAACTGACAAATAAATTTGAGTCATTCCAAAAGATGGGTAAGCA

GAGTGGTTTTTTGTTTTATGTTCCGGCATGGAACACATCCAAAATCGATCCAACT

ACAGGCTTCGTGAATTATTTCTACACTAAATATGAAAATGTGGATAAAGCAAAAG

CTTTCTTTGAGAAGTTCGAGGCGATCCGTTTTAACGCTGAAAAGAAGTACTTCGA

GTTCGAGGTCAAAAAGTATTCAGATTTTAACCCCAAGGCTGAAGGCACCCAGCAA

GCATGGACTATTTGCACGTACGGTGAGCGAATCGAAACTAAAAGGCAAAAGGATC

AAAATAATAAGTTTGTAAGCACACCCATTAACTTGACAGAAAAGATAGAAGATTT

TCTTGGAAAAAACCAAATTGTATATGGTGACGGTAACTGTATCAAGTCACAAATT

GCTTCTAAAGACGATAAGGCCTTCTTCGAAACTCTGCTATACTGGTTTAAAATGA

CGTTGCAAATGAGAAACAGTGAAACTAGAACTGATATCGACTATTTAATATCACC

CGTGATGAACGATAATGGTACCTTTTACAATTCAAGAGATTACGAGAAATTGGAG

AACCCCACACTACCAAAAGACGCAGACGCTAATGGTGCCTACCATATTGCTAAAA

AGGGACTGATGTTGTTGAACAAGATAGATCAAGCCGACTTAACTAAAAAAGTTGA

TTTGTCAATTTCGAATAGAGATTGGTTGCAATTCGTCCAGAAAAATAAGTAA

SEQ
ATGGAACAGGAATACTACTTGGGTTTGGATATGGGAACTGGTTCAGTCGGTTGGG

ID
CTGTTACGGACTCCGAGTACCACGTGTTGAGAAAACACGGAAAGGCTTTATGGGG

NO:
TGTCAGACTATTCGAATCAGCATCGACCGCGGAAGAGAGAAGAATGTTTAGAACT

135
TCAAGAAGAAGGCTGGATCGTAGGAATTGGCGGATAGAAATTTTACAAGAAATAT

TCGCCGAAGAAATCTCTAAAAAAGATCCAGGATTTTTTCTACGTATGAAGGAATC

CAAATACTATCCGGAAGATAAACGTGATATTAATGGCAATTGTCCAGAGTTACCC

TATGCTTTATTTGTGGACGACGATTTCACCGATAAAGATTACCATAAGAAGTTCC

CAACAATTTACCATCTGAGAAAGATGTTAATGAACACTGAAGAAACCCCGGATAT

AAGACTGGTCTATCTAGCCATTCATCATATGATGAAACACAGGGGACACTTCTTG

CTATCAGGGGATATAAATGAAATTAAAGAATTTGGTACAACATTTTCTAAATTAT

TGGAAAATATTAAAAACGAAGAATTAGATTGGAATTTAGAATTAGGCAAGGAGGA

ATACGCAGTTGTCGAATCGATTCTGAAAGATAACATGTTGAACAGATCAACGAAA

AAAACAAGGCTGATCAAGGCTTTAAAAGCGAAATCAATATGCGAAAAAGCAGTAT

TGAATTTGTTAGCTGGGGGGACTGTCAAGTTGTCTGATATTTTCGGATTGGAAGA

ATTGAATGAAACAGAGAGACCGAAGATATCCTTCGCCGATAATGGCTACGATGAT

TATATAGGCGAAGTCGAAAATGAGCTGGGCGAACAATTCTACATTATCGAGACTG

CCAAGGCTGTTTATGATTGGGCGGTGTTAGTCGAAATCCTTGGCAAATACACTTC

CATCTCCGAAGCTAAGGTGGCAACCTACGAAAAGCATAAAAGTGATTTGCAATTC

CTTAAGAAAATTGTCCGAAAGTACTTGACCAAAGAAGAGTACAAGGATATTTTCG

TATCAACATCGGACAAACTGAAGAATTATTCAGCTTATATTGGCATGACGAAAAT

TAATGGTAAGAAAGTTGATTTGCAATCCAAGAGATGTTCTAAAGAAGAATTTTAC

GATTTCATTAAAAAAAATGTCCTAAAAAAGTTGGAGGGACAACCTGAATATGAGT

ATTTAAAGGAAGAACTGGAAAGAGAAACTTTCCTACCAAAGCAAGTTAATCGTGA

TAATGGCGTTATTCCATACCAAATACACTTGTACGAATTAAAGAAGATCTTGGGT

AACTTGAGGGACAAAATTGATTTAATCAAGGAAAATGAAGACAAACTGGTACAAT

TATTTGAATTTAGAATACCTTACTACGTGGGCCCTTTAAACAAAATAGACGATGG

TAAGGAAGGGAAGTTCACATGGGCAGTCAGAAAGTCCAATGAAAAAATTTACCCA

TGGAATTTCGAAAACGTTGTAGATATTGAAGCTTCTGCTGAGAAATTTATTAGGA

GAATGACAAATAAATGCACTTATCTTATGGGGGAAGACGTGTTGCCTAAAGATAG

TTTATTATATTCAAAGTATATGGTCTTAAATGAATTAAACAATGTTAAATTAGAT

GGTGAAAAACTTTCCGTCGAATTGAAACAAAGATTGTATACAGATGTATTCTGCA

AATATAGAAAAGTAACTGTAAAGAAGATTAAAAACTACCTTAAATGTGAAGGCAT

TATCAGCGGAAATGTTGAGATCACTGGTATCGATGGTGATTTTAAGGCATCTTTA

ACCGCATATCACGACTTTAAGGAAATATTGACGGGTACTGAGCTTGCTAAAAAAG

ACAAAGAGAACATTATCACCAATATCGTGCTCTTCGGAGACGACAAGAAATTATT

GAAAAAGAGATTGAACCGCCTATACCCTCAGATTACCCCTAACCAATTGAAGAAA

ATCTGCGCTCTGTCTTATACTGGATGGGGTCGTTTTAGCAAGAAGTTTCTAGAAG

AAATTACTGCTCCGGATCCTGAAACTGGGGAAGTCTGGAATATAATTACCGCGCT

ATGGGAATCGAATAATAATTTAATGCAATTACTATCTAATGAATACAGATTTATG

GAAGAAGTCGAAACTTACAATATGGGAAAACAAACAAAAACTTTGAGCTACGAAA

CAGTAGAGAATATGTATGTCTCACCATCTGTAAAGCGGCAGATCTGGCAAACCTT

GAAGATAGTTAAAGAATTAGAAAAAGTGATGAAGGAAAGTCCAAAAAGGGTTTTT

ATTGAAATGGCCCGAGAAAAACAAGAATCTAAAAGGACGGAAAGTAGGAAAAAGC

AACTTATAGATCTATATAAAGCCTGCAAAAATGAAGAAAAAGATTGGGTAAAGGA

ATTAGGTGACCAGGAAGAGCAAAAATTGAGATCTGACAAGCTGTACTTGTATTAT

ACGCAAAAGGGCCGGTGTATGTATTCGGGTGAGGTAATAGAATTGAAAGATTTAT

GGGATAACACTAAGTATGACATTGACCATATTTACCCCCAGTCTAAGACAATGGA

CGATTCATTAAATAACCGAGTTCTTGTCAAAAAGAAGTACAATGCCACAAAGAGC

GATAAGTACCCATTGAACGAAAATATAAGACATGAACGAAAAGGTTTCTGGAAAT

CATTGTTGGACGGTGGATTTATTTCCAAAGAAAAATACGAGAGATTGATTAGAAA

CACTGAACTATCTCCAGAGGAGTTAGCTGGCTTTATCGAAAGACAAATTGTTGAA

ACTAGACAGTCTACAAAAGCAGTTGCAGAAATCTTAAAACAAGTATTTCCAGAAT

CCGAAATTGTGTACGTCAAAGCCGGAACAGTAAGTAGATTTAGAAAAGACTTTGA

ATTATTGAAAGTACGAGAGGTTAACGACCTACATCATGCTAAGGATGCTTATTTA

AATATAGTCGTTGGTAATTCGTATTACGTGAAATTCACAAAAAACGCATCTTGGT

TCATCAAGGAGAATCCTGGTAGGACATACAACTTGAAAAAGATGTTTACATCAGG

ATGGAATATCGAAAGAAATGGTGAGGTTGCGTGGGAGGTAGGCAAGAAGGGAACC

ATTGTTACTGTAAAGCAAATTATGAATAAAAACAATATACTTGTTACGAGACAGG

TGCACGAAGCCAAAGGAGGGTTGTTTGACCAGCAAATCATGAAGAAAGGTAAAGG

TCAGATAGCAATAAAAGAGACTGATGAGCGTTTAGCTAGTATAGAAAAATATGGG

GGCTACAATAAGGCAGCTGGTGCTTACTTCATGTTGGTCGAATCAAAGGATAAAA

AAGGGAAGACGATCCGGACCATAGAGTTTATCCCTCTGTACTTGAAGAATAAGAT

TGAGTCTGACGAAAGCATCGCATTGAATTTCTTGGAAAAGGGGCGCGGTCTAAAG

GAGCCAAAAATATTGTTAAAGAAAATTAAAATAGACACCCTATTCGACGTCGATG

GGTTTAAGATGTGGCTTAGTGGTCGTACTGGGGACAGATTATTATTCAAGTGTGC

CAATCAGTTAATCCTTGACGAGAAAATCATTGTTACAATGAAAAAAATTGTTAAG

TTTATTCAAAGGCGACAAGAAAATAGAGAACTAAAGTTGAGTGATAAGGATGGAA

TCGATAATGAAGTGTTAATGGAGATTTATAACACTTTTGTCGACAAATTGGAGAA

TACGGTGTACAGAATTAGGCTATCTGAACAGGCTAAAACCCTAATTGATAAACAG

AAGGAGTTTGAGCGACTTTCTCTTGAAGACAAATCTTCAACTCTTTTCGAGATCC

TACATATCTTTCAGTGTCAATCTTCTGCAGCTAATTTGAAAATGATTGGAGGTCC

TGGTAAGGCTGGTATATTAGTCATGAACAACAACATATCTAAGTGTAATAAGATT

AGTATAATTAACCAATCACCGACAGGTATCTTTGAAAATGAAATTGATTTACTTA

AA

SEQ
ATGAAATCATTCGACTCGTTCACCAACTTGTACTCCCTGTCTAAAACATTGAAAT

ID
TTGAAATGCGACCTGTTGGTAACACCCAAAAGATGTTAGATAATGCAGGAGTTTT

NO:
CGAAAAGGATAAACTGATCCAGAAAAAATACGGTAAAACGAAACCATATTTCGAT

136
AGGTTGCATCGGGAATTTATAGAAGAAGCTTTGACTGGTGTAGAATTAATTGGCT

TAGATGAGAATTTCCGTACTCTAGTCGATTGGCAAAAAGATAAAAAGAACAATGT

TGCCATGAAGGCATACGAAAATAGTCTACAAAGACTAAGAACAGAGATCGGGAAA

ATTTTCAATTTGAAGGCAGAAGACTGGGTGAAGAACAAATATCCAATATTGGGTC

TTAAGAATAAGAATACTGATATATTGTTCGAGGAGGCCGTTTTCGGTATTCTTAA

GGCAAGATATGGTGAAGAGAAAGACACGTTTATTGAAGTTGAGGAGATTGATAAA

ACCGGTAAGTCCAAAATCAACCAGATCTCTATCTTCGACAGTTGGAAGGGCTTCA

CTGGTTATTTTAAGAAGTTCTTCGAAACTAGGAAGAACTTCTATAAAAACGATGG

TACTTCCACGGCTATTGCTACAAGAATTATCGACCAAAACCTTAAGCGTTTTATT

GATAACCTATCAATTGTTGAAAGTGTTCGACAGAAAGTAGATTTGGCTGAAACTG

AAAAATCTTTTAGTATCTCCTTATCCCAGTTTTTCTCTATAGATTTTTATAATAA

ATGTTTGCTGCAAGATGGCATTGACTACTATAATAAAATAATTGGTGGAGAGACA

TTGAAAAACGGAGAGAAGCTGATTGGCCTTAATGAGTTGATAAATCAATATAGAC

AAAATAATAAGGACCAGAAAATCCCTTTCTTTAAATTGCTAGACAAACAGATTTT

GTCTGAAAAGATCCTATTCTTGGATGAAATAAAGAACGATACTGAATTGATTGAA

GCTTTGTCCCAGTTTGCTAAAACAGCTGAAGAAAAGACAAAGATTGTGAAAAAAT

TGTTTGCTGATTTCGTAGAAAACAATTCTAAATATGATCTAGCCCAGATTTATAT

AAGTCAAGAAGCTTTCAATACAATAAGTAATAAGTGGACAAGTGAAACAGAAACT

TTTGCTAAGTATTTATTCGAAGCCATGAAGTCTGGTAAACTTGCCAAATACGAAA

AAAAAGATAACAGTTATAAATTTCCAGACTTTATAGCCCTTTCACAGATGAAGTC

TGCCTTATTGTCGATATCCTTAGAAGGTCATTTTTGGAAGGAAAAATATTATAAG

ATAAGCAAGTTCCAAGAAAAGACTAATTGGGAACAATTTTTGGCTATATTTCTAT

ATGAGTTCAATTCATTATTTTCCGATAAAATCAACACTAAGGATGGAGAGACTAA

GCAAGTTGGCTACTATTTGTTCGCAAAAGATCTGCACAATTTGATTCTATCAGAA

CAAATAGATATACCAAAAGATTCAAAGGTAACTATAAAGGATTTCGCAGATTCCG

TCCTCACCATTTATCAAATGGCTAAATATTTTGCCGTTGAAAAAAAGAGAGCGTG

GTTAGCAGAATACGAGTTGGACTCGTTTTATACTCAGCCAGATACTGGATACTTG

CAATTCTACGATAATGCATACGAAGACATTGTACAGGTATACAATAAACTTAGAA

ATTACTTAACCAAGAAGCCCTACAGTGAAGAAAAATGGAAGCTGAACTTTGAAAA

TTCGACTTTGGCAAATGGTTGGGATAAAAATAAAGAAAGTGACAACTCCGCAGTG

ATTTTGCAAAAGGGTGGGAAATATTACTTGGGTTTAATCACAAAAGGCCACAATA

AGATTTTTGATGATAGATTTCAAGAAAAATTCATAGTTGGTATAGAAGGTGGCAA

ATACGAGAAAATTGTCTATAAATTCTTCCCTGATCAAGCCAAAATGTTCCCAAAA

GTTTGCTTTTCTGCTAAAGGATTGGAGTTTTTCCGGCCTAGCGAGGAGATCCTTC

GTATCTACAACAATGCTGAATTCAAAAAAGGAGAAACCTATAGCATAGATTCTAT

GCAAAAACTGATAGATTTTTATAAGGATTGTTTAACAAAGTACGAAGGCTGGGCC

TGCTATACATTTAGACATTTAAAGCCCACAGAAGAATACCAAAATAACATTGGTG

AATTCTTTCGGGACGTTGCCGAAGACGGCTATAGGATCGATTTTCAAGGTATCTC

AGATCAATATATCCACGAAAAGAACGAGAAGGGTGAGCTGCACCTTTTCGAAATT

CATAATAAGGACTGGAATTTGGATAAGGCGAGAGATGGTAAATCGAAGACCACTC

AAAAGAACTTGCATACTTTATATTTTGAGTCCTTGTTTTCTAATGATAACGTCGT

CCAAAATTTTCCAATAAAGTTGAATGGACAAGCGGAAATTTTCTATCGGCCTAAG

ACAGAGAAAGACAAATTAGAATCAAAGAAAGATAAAAAGGGAAATAAAGTCATTG

ATCACAAACGATACTCTGAGAATAAAATATTTTTCCACGTACCATTGACACTCAA

CAGGACTAAGAATGACTCTTATAGATTTAATGCTCAGATTAATAATTTTTTGGCA

AATAACAAGGATATTAACATAATTGGGGTGGATAGAGGTGAAAAGCACTTGGTAT

ATTACTCTGTCATCACTCAGGCTTCTGATATATTGGAAAGCGGGTCTCTAAATGA

ATTGAACGGTGTTAACTACGCCGAAAAGCTAGGTAAAAAAGCTGAAAACAGAGAG

CAGGCTCGGCGCGATTGGCAAGATGTTCAAGGAATTAAAGACCTTAAAAAAGGCT

ACATTAGTCAAGTAGTTAGAAAGTTAGCCGATCTTGCTATTAAACATAACGCAAT

CATTATTCTGGAGGACCTAAATATGCGTTTTAAGCAAGTTAGGGGTGGCATAGAA

AAAAGTATTTATCAGCAGCTTGAGAAGGCTTTGATAGATAAGTTATCGTTCCTAG

TTGACAAAGGTGAAAAAAATCCTGAACAAGCTGGTCATCTGTTGAAAGCTTATCA

GCTGAGCGCACCTTTTGAAACATTTCAAAAAATGGGAAAACAAACAGGTATTATT

TTCTATACTCAAGCGAGTTATACAAGTAAATCTGACCCAGTGACAGGATGGAGAC

CACACCTTTATCTAAAATATTTTTCTGCTAAAAAGGCCAAAGATGACATCGCTAA

GTTTACAAAAATAGAATTTGTCAACGATAGATTTGAATTGACTTACGATATTAAA

GATTTTCAGCAAGCAAAAGAATACCCAAATAAGACAGTGTGGAAAGTATGCTCCA

ATGTGGAGAGATTTAGATGGGATAAAAATCTCAATCAAAACAAGGGTGGTTACAC

ACATTATACTAATATAACTGAAAATATTCAAGAATTGTTTACTAAGTACGGAATT

GACATAACCAAAGACTTACTAACTCAGATTTCAACTATTGACGAAAAACAAAATA

CCTCATTTTTCCGCGACTTTATTTTTTATTTCAACTTGATCTGTCAAATTCGTAA

CACGGATGATTCCGAAATTGCCAAGAAGAACGGAAAAGATGATTTCATCCTATCT

CCAGTGGAACCATTTTTTGACTCAAGAAAAGATAATGGTAATAAGTTGCCTGAGA

ACGGAGATGATAACGGCGCTTATAATATCGCTCGGAAGGGTATTGTAATTCTTAA

TAAAATATCTCAGTACTCTGAAAAGAACGAAAACTGCGAGAAAATGAAGTGGGGC

GACTTGTATGTATCTAATATAGATTGGGATAATTTCGTTACTCAAGCCAACGCGA

GACATTGA

SEQ
ATGGAAAATTTTAAAAACCTATATCCAATTAATAAGACACTTAGATTCGAGCTTA

ID
GGCCATACGGCAAAACACTAGAAAATTTTAAGAAGTCAGGCCTATTAGAAAAAGA

NO:
CGCCTTTAAGGCAAATTCCAGAAGATCAATGCAGGCAATTATTGATGAGAAATTT

137
AAAGAGACTATCGAGGAAAGGTTGAAATACACTGAATTCTCTGAGTGCGATCTGG

GAAACATGACTTCCAAGGATAAAAAGATTACCGATAAGGCTGCTACCAACCTCAA

AAAGCAAGTCATCTTATCGTTTGATGATGAAATTTTTAATAACTACTTAAAGCCG

GACAAAAACATTGACGCCCTATTCAAAAATGATCCGTCCAACCCCGTAATTTCAA

CTTTTAAGGGTTTTACCACGTACTTTGTAAATTTTTTTGAGATTCGTAAACATAT

CTTCAAAGGAGAATCGTCGGGTTCCATGGCCTATAGGATAATTGATGAAAATCTT

ACGACTTACTTAAACAATATCGAAAAGATAAAAAAGTTACCAGAAGAATTAAAGT

CTCAATTGGAAGGTATTGACCAAATAGACAAATTAAATAACTATAATGAGTTCAT

AACTCAAAGCGGTATCACACATTACAATGAAATTATCGGTGGTATATCTAAAAGT

GAGAACGTAAAAATACAGGGAATAAACGAGGGGATCAATCTATACTGTCAGAAGA

ATAAAGTAAAATTACCAAGACTAACGCCATTATACAAAATGATTCTGTCTGATAG

AGTTTCCAACTCGTTCGTGCTTGATACTATAGAAAATGATACTGAATTAATTGAG

ATGATTAGCGACTTGATTAATAAAACAGAAATATCTCAAGACGTAATAATGTCAG

ACATTCAGAACATTTTCATAAAATATAAACAGCTTGGTAATTTACCGGGGATAAG

TTACTCTAGCATCGTGAATGCTATTTGCTCCGATTATGACAATAATTTTGGTGAC

GGAAAAAGAAAAAAATCATATGAGAACGATAGGAAGAAACACCTTGAAACAAACG

TATACTCAATTAACTATATATCGGAACTGTTAACAGACACCGATGTATCATCTAA

TATAAAAATGAGATATAAGGAACTTGAACAAAATTACCAGGTGTGTAAGGAGAAT

TTCAATGCTACCAACTGGATGAACATTAAGAATATTAAACAGAGTGAAAAGACAA

ACTTGATTAAAGATCTACTAGATATACTGAAATCAATACAGAGATTCTACGATCT

GTTTGATATAGTTGATGAAGACAAAAATCCTAGTGCTGAGTTTTACACGTGGCTA

AGTAAAAATGCGGAAAAGTTAGATTTCGAGTTCAACTCTGTTTATAATAAATCTA

GGAATTATTTAACTAGAAAGCAGTATTCTGATAAAAAGATAAAATTGAACTTCGA

CTCCCCTACGTTGGCAAAGGGTTGGGATGCAAACAAAGAAATCGATAACTCCACC

ATAATAATGCGTAAGTTTAACAATGATAGGGGGGATTACGATTATTTTTTGGGAA

TTTGGAACAAATCTACCCCAGCGAATGAAAAAATTATTCCCCTTGAAGACAATGG

TCTTTTTGAAAAAATGCAGTATAAATTATATCCAGACCCATCCAAGATGCTTCCA

AAGCAATTTCTGTCAAAAATTTGGAAGGCTAAACACCCTACTACTCCTGAATTTG

ATAAGAAGTATAAGGAGGGCCGACACAAAAAGGGTCCAGATTTTGAAAAAGAATT

CCTGCATGAATTGATAGATTGTTTTAAGCATGGTTTGGTAAATCATGATGAAAAA

TATCAGGATGTCTTTGGATTCAATTTGAGAAATACAGAGGATTACAACTCATATA

CAGAATTTCTCGAGGACGTCGAACGTTGCAATTATAATCTCAGTTTCAACAAGAT

CGCAGACACTTCAAACTTAATTAACGACGGAAAATTGTACGTTTTTCAAATCTGG

TCGAAAGACTTTAGTATTGATTCAAAGGGTACAAAAAACCTAAATACAATATATT

TCGAAAGTCTATTCTCGGAAGAAAACATGATCGAAAAAATGTTCAAACTGTCAGG

CGAAGCTGAAATATTCTACCGTCCCGCAAGCCTTAATTATTGTGAGGATATCATT

AAAAAAGGACATCACCATGCAGAGTTAAAAGATAAATTCGATTACCCAATAATTA

AAGATAAAAGATACTCCCAGGATAAGTTCTTTTTCCATGTACCTATGGTTATTAA

CTACAAGTCGGAAAAACTAAACTCGAAGTCATTAAATAATAGAACTAACGAGAAC

TTGGGACAATTCACACATATAATTGGTATTGATCGTGGCGAAAGACATTTAATAT

ATCTGACTGTTGTTGATGTTTCAACAGGAGAAATTGTTGAACAGAAACATCTTGA

TGAAATTATAAACACAGATACAAAAGGCGTTGAGCATAAAACTCATTATCTAAAT

AAATTGGAGGAAAAGTCGAAGACTCGCGATAACGAGAGAAAGAGTTGGGAAGCAA

TTGAAACCATAAAAGAGCTTAAAGAAGGTTACATTAGTCACGTCATCAATGAAAT

ACAAAAGTTACAAGAAAAGTATAACGCTTTGATTGTAATGGAAAATCTAAATTAT

GGTTTTAAGAATTCAAGAATCAAAGTCGAAAAGCAGGTCTATCAGAAATTTGAAA

CGGCACTTATTAAAAAGTTTAACTACATTATTGATAAAAAGGACCCAGAAACTTA

TATTCATGGTTACCAACTGACGAACCCAATCACAACATTGGACAAAATTGGAAAC

CAAAGTGGAATTGTTTTATACATTCCAGCTTGGAATACATCCAAAATAGACCCTG

TCACGGGGTTTGTCAACTTGTTATATGCCGACGATTTAAAGTATAAAAACCAAGA

ACAAGCAAAGTCTTTTATTCAAAAGATTGATAATATTTATTTCGAAAACGGTGAA

TTTAAATTCGACATAGATTTTTCTAAATGGAACAACCGTTATTCAATAAGTAAAA

CTAAATGGACACTCACCTCATACGGCACTCGTATCCAAACCTTTCGGAATCCCCA

AAAAAATAACAAATGGGATTCTGCAGAATACGACTTGACCGAGGAATTTAAATTA

ATTCTTAATATAGACGGTACACTCAAAAGTCAAGACGTGGAGACATACAAGAAGT

TTATGTCGTTATTCAAGCTTATGCTTCAGTTGAGGAACTCCGTTACAGGCACTGA

TATTGATTACATGATTTCACCAGTAACGGATAAGACTGGGACTCATTTCGATTCT

AGGGAAAATATTAAAAATTTACCTGCTGACGCAGACGCAAACGGCGCATACAATA

TAGCAAGAAAAGGGATTATGGCCATTGAGAATATTATGAATGGCATATCAGATCC

ATTAAAGATAAGCAATGAAGACTACTTAAAATACATTCAGAATCAGCAAGAATAA

SEQ
ATGACCCAGTTTGAAGGTTTCACCAATTTGTACCAAGTAAGTAAAACCTTGAGGT

ID
TCGAATTGATCCCACAGGGCAAGACATTGAAGCATATTCAAGAGCAAGGATTTAT

NO:
AGAAGAAGATAAAGCGAGAAACGATCACTATAAAGAGTTAAAACCCATTATTGAC

138
AGGATCTATAAAACATACGCCGATCAATGCCTTCAATTAGTGCAATTAGATTGGG

AAAACTTGAGCGCTGCCATCGATTCCTACAGGAAGGAAAAAACAGAAGAAACAAG

AAATGCCTTAATCGAGGAACAAGCAACCTATAGAAACGCTATACACGATTACTTC

ATCGGTAGAACTGATAATCTAACAGATGCAATAAATAAGAGACATGCTGAGATAT

ATAAAGGACTATTTAAAGCAGAATTATTCAACGGAAAGGTGTTGAAACAGTTAGG

TACCGTTACAACTACTGAGCATGAAAATGCCTTGCTGAGAAGCTTTGACAAGTTT

ACTACCTACTTTTCGGGTTTCTACGAAAATCGCAAAAATGTATTTTCTGCGGAAG

ATATTTCAACTGCAATCCCTCATAGGATTGTTCAAGATAATTTCCCTAAGTTTAA

AGAGAACTGTCACATTTTTACAAGGTTAATTACTGCGGTTCCAAGTCTAAGAGAA

CATTTTGAGAATGTAAAAAAAGCGATTGGTATATTTGTATCCACTAGCATTGAAG

AGGTTTTCAGCTTCCCTTTTTATAACCAATTACTTACCCAAACACAGATCGACCT

GTACAACCAATTGTTAGGTGGTATATCGAGGGAGGCTGGTACGGAAAAGATTAAA

GGATTAAATGAAGTTCTTAATTTGGCCATACAAAAAAATGATGAAACCGCGCACA

TTATCGCATCTTTACCACATAGGTTTATACCGTTATTCAAGCAAATATTATCTGA

TCGTAATACCTTATCGTTCATATTAGAGGAGTTTAAATCTGACGAAGAAGTTATA

CAATCTTTTTGCAAGTATAAGACGCTATTGAGAAACGAAAACGTTCTGGAAACAG

CCGAAGCACTGTTCAATGAATTAAACAGTATCGACTTGACTCATATTTTTATATC

GCATAAAAAGTTGGAGACAATTTCTTCAGCATTGTGCGATCACTGGGACACTTTA

AGGAACGCACTATATGAACGTAGGATCTCAGAATTGACAGGTAAGATAACGAAGT

CTGCTAAAGAGAAAGTGCAGAGATCCCTAAAACACGAGGATATAAATTTGCAGGA

GATAATTTCAGCTGCAGGTAAAGAGTTGTCTGAAGCGTTCAAGCAAAAGACTTCC

GAAATCTTGTCACACGCACACGCCGCATTAGATCAACCTTTACCCACTACTTTGA

AAAAACAAGAAGAGAAGGAGATATTAAAATCACAACTTGATTCTTTACTTGGCCT

TTATCATCTTTTAGATTGGTTCGCTGTTGACGAGAGCAATGAAGTGGATCCAGAG

TTTTCCGCAAGATTGACCGGTATAAAGTTGGAAATGGAACCTTCGTTATCATTTT

ACAACAAAGCTAGGAACTATGCTACAAAAAAACCTTATTCTGTCGAAAAATTTAA

ACTGAACTTCCAAATGCCTACTCTAGCAAGTGGCTGGGATGTTAATAAAGAAAAG

AACAATGGCGCTATTTTGTTTGTAAAAAATGGCCTATACTATCTTGGAATTATGC

CTAAACAAAAAGGTCGCTACAAGGCTTTGTCATTTGAACCTACTGAAAAGACTAG

CGAAGGTTTCGATAAGATGTATTACGATTATTTCCCGGATGCCGCTAAAATGATC

CCCAAGTGCTCTACTCAATTGAAGGCAGTAACTGCTCATTTCCAAACGCATACCA

CGCCAATACTGCTTTCTAACAACTTTATAGAACCACTAGAAATAACGAAAGAAAT

TTACGACCTAAATAACCCAGAGAAAGAACCAAAAAAGTTCCAGACGGCCTACGCC

AAAAAGACAGGGGACCAAAAAGGTTACCGCGAGGCGTTATGTAAATGGATTGATT

TTACTAGGGACTTTTTATCAAAATACACTAAAACGACGTCTATTGATCTTAGCTC

CTTACGCCCGTCCTCCCAATACAAGGATCTAGGTGAGTATTACGCAGAGTTGAAC

CCGCTATTATACCATATTTCCTTCCAAAGGATTGCTGAAAAGGAAATTATGGACG

CTGTTGAAACTGGGAAATTGTACCTGTTTCAGATTTATAATAAGGACTTCGCAAA

GGGTCACCATGGTAAGCCTAACCTTCACACTTTGTACTGGACCGGACTATTCTCG

CCTGAAAATTTGGCTAAAACAAGTATCAAGTTAAACGGTCAGGCCGAGTTATTTT

ATAGACCCAAATCTAGAATGAAAAGAATGGCCCATAGATTAGGCGAAAAGATGTT

AAACAAGAAATTAAAGGACCAAAAAACCCCGATACCAGACACTCTATACCAAGAA

CTGTACGACTATGTGAATCACAGGCTTAGTCACGATTTATCAGATGAAGCGAGGG

CTTTATTGCCAAATGTCATCACCAAGGAAGTATCACATGAAATAATTAAGGATAG

AAGGTTCACATCTGATAAATTCTTTTTTCATGTCCCAATTACATTGAATTATCAA

GCAGCGAACTCACCATCTAAATTTAATCAGCGCGTCAACGCCTATTTGAAAGAAC

ATCCCGAAACACCAATCATCGGCATAGATCGAGGTGAGAGAAACTTAATATATAT

AACTGTGATTGATTCTACAGGAAAAATCCTGGAGCAACGATCTTTAAATACCATA

CAACAGTTTGATTATCAAAAAAAGTTGGATAACAGAGAAAAAGAACGTGTTGCCG

CTAGGCAGGCTTGGTCTGTGGTAGGAACAATTAAGGACTTAAAGCAGGGCTATCT

GTCCCAAGTTATTCATGAAATAGTCGATCTGATGATACATTATCAGGCAGTTGTC

GTGTTGGAAAATTTGAATTTTGGCTTTAAATCAAAAAGAACTGGCATAGCAGAAA

AAGCTGTGTACCAGCAGTTTGAAAAGATGTTAATCGATAAGCTAAACTGCCTTGT

TCTTAAAGATTACCCCGCAGAAAAAGTAGGTGGTGTTCTTAATCCATATCAGTTG

ACAGACCAATTTACATCCTTTGCGAAAATGGGTACGCAAAGCGGGTTCTTATTCT

ACGTACCGGCCCCCTATACTTCTAAGATCGACCCACTAACAGGTTTTGTGGACCC

TTTTGTTTGGAAGACGATAAAGAACCACGAGTCACGCAAACATTTCTTAGAGGGC

TTTGATTTCTTGCACTACGACGTGAAAACTGGTGATTTTATCTTACACTTTAAAA

TGAACAGAAATCTCTCTTTCCAACGTGGACTGCCCGGATTCATGCCGGCTTGGGA

CATCGTTTTTGAAAAGAATGAAACGCAGTTTGACGCCAAAGGTACACCATTTATA

GCGGGTAAGAGAATTGTGCCGGTCATAGAAAACCATAGATTTACAGGTAGATATA

GGGATCTGTACCCTGCTAATGAATTGATTGCATTACTCGAAGAGAAAGGAATTGT

GTTTCGAGATGGATCGAATATTTTACCTAAGTTGTTGGAAAATGATGATTCACAC

GCAATTGATACTATGGTTGCCCTCATAAGATCGGTATTGCAAATGAGAAACTCAA

ATGCTGCTACGGGAGAGGATTATATAAACAGCCCCGTTCGCGATCTTAATGGTGT

TTGTTTTGATTCACGTTTTCAGAACCCCGAATGGCCAATGGATGCCGACGCAAAC

GGAGCATATCATATTGCTCTTAAAGGCCAACTACTATTAAATCACTTAAAGGAAT

CCAAAGACCTAAAATTGCAAAACGGGATATCTAATCAGGATTGGCTGGCTTACAT

ACAAGAACTACGTAACTAG

SEQ
ATGGCCGTTAAGTCAATCAAAGTGAAACTTAGACTGGATGACATGCCAGAGATTC

ID
GTGCGGGGTTATGGAAACTTCATAAGGAAGTTAACGCAGGGGTAAGATATTATAC

NO:
CGAATGGTTATCATTACTTCGACAAGAGAATTTGTACAGAAGGTCCCCGAACGGC

139
GACGGTGAGCAAGAATGCGATAAGACGGCTGAAGAATGTAAGGCAGAACTTTTGG

AGCGCCTGAGAGCCCGTCAGGTTGAAAATGGCCATAGAGGTCCTGCGGGATCTGA

TGATGAGCTTTTACAGCTAGCTAGACAATTGTATGAATTGTTGGTCCCTCAGGCT

ATTGGGGCTAAAGGAGACGCTCAACAAATCGCCAGAAAGTTCTTGTCACCTCTGG

CTGACAAAGATGCCGTGGGAGGATTAGGTATCGCTAAAGCAGGTAATAAACCAAG

ATGGGTTAGAATGAGAGAAGCAGGCGAACCTGGTTGGGAAGAAGAGAAAGAAAAG

GCCGAAACTAGAAAAAGCGCTGACAGAACCGCAGATGTTTTACGGGCCTTGGCTG

ATTTTGGACTGAAGCCTTTGATGAGAGTGTATACTGATTCAGAAATGTCTTCCGT

TGAATGGAAGCCCCTAAGGAAGGGACAAGCGGTCAGAACCTGGGATAGGGATATG

TTTCAACAGGCTATTGAAAGGATGATGTCATGGGAATCCTGGAATCAAAGAGTAG

GTCAAGAATACGCTAAACTGGTCGAACAAAAGAATAGATTTGAACAAAAAAATTT

TGTAGGTCAAGAACATTTAGTACATTTGGTTAATCAACTTCAACAAGATATGAAA

GAGGCATCTCCTGGTTTGGAATCAAAAGAACAAACAGCACACTATGTTACCGGCC

GAGCTTTGCGAGGTTCTGACAAAGTATTTGAAAAGTGGGGGAAATTAGCTCCCGA

TGCCCCCTTTGATCTATATGATGCTGAAATTAAAAACGTTCAAAGAAGGAACACT

AGACGTTTTGGATCCCATGATCTTTTTGCAAAGCTAGCTGAGCCAGAATACCAGG

CTCTATGGCGTGAAGACGCCTCGTTTTTGACTAGATACGCAGTATACAATTCAAT

ACTCAGAAAACTAAACCATGCCAAGATGTTTGCTACATTCACCCTGCCCGATGCT

ACCGCTCATCCTATTTGGACTAGATTTGACAAGTTGGGGGGGAATCTACATCAGT

ACACATTTTTATTTAATGAATTCGGTGAAAGAAGACACGCTATTAGATTCCACAA

GCTCCTAAAGGTTGAAAACGGCGTTGCGAGAGAAGTTGATGATGTAACAGTTCCC

ATTTCTATGTCGGAGCAATTGGATAATCTATTGCCTAGAGACCCTAATGAACCAA

TTGCTTTGTACTTTCGTGACTACGGTGCAGAACAACACTTTACAGGTGAATTCGG

CGGAGCCAAGATTCAATGTAGACGTGATCAACTCGCACACATGCATAGAAGAAGA

GGCGCTCGTGATGTTTATTTAAATGTGTCTGTTAGAGTTCAATCCCAATCGGAGG

CTAGAGGTGAAAGAAGGCCACCATACGCAGCAGTTTTTAGGTTAGTAGGTGATAA

TCATAGGGCATTTGTCCACTTCGACAAATTAAGTGATTATTTAGCAGAGCACCCT

GATGATGGAAAGTTGGGCAGTGAGGGATTATTAAGTGGGTTGAGGGTAATGTCTG

TAGATCTTGGTCTTCGTACTTCTGCGAGTATCTCTGTCTTTAGAGTAGCACGTAA

GGATGAGTTGAAACCTAATAGCAAAGGAAGAGTCCCGTTTTTTTTTCCTATTAAG

GGTAACGATAACCTGGTGGCCGTGCATGAAAGATCACAACTTTTGAAATTGCCAG

GAGAAACGGAGTCCAAGGACTTGAGGGCAATTAGAGAGGAACGTCAGCGTACATT

GCGACAGCTGAGAACTCAATTGGCTTATTTGAGGTTGTTGGTTAGGTGTGGTTCC

GAGGATGTTGGCAGAAGAGAAAGGTCTTGGGCCAAATTGATAGAACAACCAGTGG

ACGCCGCAAATCACATGACACCAGATTGGAGAGAAGCTTTCGAAAATGAACTCCA

GAAATTAAAGAGCCTACATGGCATATGCTCTGATAAAGAGTGGATGGATGCCGTA

TACGAATCCGTTCGTAGAGTCTGGCGCCACATGGGTAAGCAAGTACGGGACTGGA

GAAAGGATGTTCGTTCCGGCGAAAGACCGAAGATAAGGGGGTATGCAAAGGACGT

TGTAGGCGGTAATTCTATTGAACAGATTGAGTATTTGGAAAGGCAGTACAAATTT

CTTAAATCCTGGAGCTTCTTCGGCAAAGTGTCAGGACAAGTCATCAGGGCTGAAA

AAGGTTCCAGATTTGCTATTACGCTAAGGGAACATATTGATCATGCGAAAGAAGA

TAGACTGAAAAAACTAGCAGATAGAATAATTATGGAAGCACTTGGTTACGTCTAT

GCACTTGATGAAAGAGGCAAGGGGAAATGGGTAGCTAAATACCCGCCTTGTCAAC

TTATTTTATTAGAAGAATTAAGCGAGTACCAATTTAACAACGATAGACCTCCATC

CGAAAATAATCAGCTGATGCAATGGTCCCATAGGGGTGTTTTTCAAGAATTGATA

AATCAAGCTCAAGTACACGATTTGCTGGTAGGTACTATGTACGCAGCGTTTTCGA

GCCGTTTTGATGCAAGAACTGGTGCCCCAGGTATCAGATGTCGACGTGTTCCGGC

CAGATGTACACAGGAACATAACCCTGAGCCATTTCCGTGGTGGCTTAATAAGTTT

GTTGTCGAGCACACATTAGACGCATGCCCTCTGAGAGCAGATGACCTTATACCCA

CTGGAGAAGGCGAAATATTTGTTAGTCCATTCTCTGCAGAAGAAGGTGACTTTCA

CCAGATACATGCAGACTTAAATGCAGCACAGAATCTCCAACAAAGGTTGTGGTCG

GATTTTGATATTTCGCAAATAAGACTAAGATGCGATTGGGGAGAGGTTGATGGAG

AATTGGTGCTGATTCCAAGATTAACCGGAAAGCGAACTGCCGATTCCTATTCTAA

CAAGGTGTTTTACACAAATACTGGTGTTACCTATTACGAAAGAGAAAGGGGTAAG

AAGAGACGTAAAGTATTTGCTCAAGAAAAATTGTCAGAAGAGGAGGCAGAACTGT

TAGTAGAAGCAGACGAAGCCAGAGAAAAATCAGTTGTGCTTATGCGTGACCCTTC

CGGCATTATAAATCGTGGTAATTGGACACGACAAAAAGAATTTTGGTCTATGGTC

AATCAACGTATCGAAGGCTACCTAGTTAAGCAAATCAGGTCTAGGGTTCCACTAC

AAGATAGCGCATGTGAAAATACGGGTGATATATAA

SEQ
ATGGCTACTAGATCTTTCATTTTAAAAATTGAACCTAATGAAGAAGTGAAGAAGG

ID
GTCTCTGGAAAACTCACGAAGTACTTAATCATGGCATTGCCTATTATATGAATAT

NO:
CCTGAAGCTTATTCGTCAAGAAGCTATATACGAGCATCATGAGCAAGATCCTAAG

140
AACCCTAAGAAAGTAAGCAAAGCGGAAATTCAGGCTGAATTGTGGGACTTCGTCT

TGAAGATGCAGAAGTGTAACAGTTTTACGCACGAAGTTGATAAAGATGTGGTGTT

TAATATTTTGAGGGAGCTATATGAGGAGTTGGTGCCCTCGAGTGTCGAAAAAAAA

GGAGAAGCTAATCAGCTGTCAAATAAATTTTTATATCCTCTGGTGGATCCAAACT

CTCAATCAGGTAAAGGCACTGCCAGTAGTGGTCGAAAACCGAGATGGTATAATTT

GAAAATCGCAGGTGATCCATCGTGGGAAGAAGAAAAAAAAAAATGGGAAGAAGAT

AAAAAAAAAGATCCCCTTGCCAAAATACTAGGTAAGCTAGCCGAGTATGGACTTA

TACCATTATTCATTCCTTTCACGGACTCTAATGAACCAATTGTGAAGGAAATCAA

ATGGATGGAAAAATCACGTAATCAGTCTGTTAGGAGGTTGGACAAAGATATGTTT

ATACAGGCTCTTGAGAGGTTTTTGTCGTGGGAGTCCTGGAATTTGAAAGTGAAAG

AAGAATATGAAAAAGTGGAAAAGGAGCATAAGACGTTGGAAGAAAGGATTAAGGA

AGATATTCAGGCCTTTAAGAGTCTGGAACAGTACGAAAAAGAAAGACAGGAACAG

TTATTGAGAGATACTCTAAACACTAATGAATATAGGCTTTCCAAGAGGGGCTTGC

GAGGATGGAGAGAGATAATTCAGAAATGGTTGAAAATGGATGAGAACGAGCCATC

GGAGAAATATCTAGAGGTGTTTAAAGATTACCAAAGAAAGCACCCTCGCGAAGCT

GGTGATTACTCTGTTTATGAATTCCTTTCGAAGAAGGAAAATCACTTCATCTGGC

GAAATCATCCAGAGTACCCATATTTATATGCTACATTTTGCGAAATTGACAAGAA

AAAAAAAGATGCTAAACAGCAAGCGACATTCACCCTCGCTGATCCCATCAACCAC

CCATTATGGGTCAGGTTCGAAGAGAGATCAGGCTCGAACCTGAATAAGTACAGGA

TCTTGACTGAGCAATTGCATACTGAGAAGTTAAAAAAGAAATTGACGGTCCAACT

TGACAGATTGATTTATCCCACTGAATCTGGTGGATGGGAGGAGAAAGGTAAGGTT

GATATTGTCCTATTGCCTTCTCGTCAATTTTACAACCAAATATTTCTGGACATCG

AAGAGAAGGGTAAACATGCTTTTACCTATAAGGATGAGAGTATTAAATTTCCATT

GAAGGGAACGCTTGGCGGCGCTAGAGTTCAGTTCGATAGAGATCATTTGAGAAGA

TACCCGCATAAAGTGGAATCTGGTAATGTAGGTCGGATCTACTTTAACATGACGG

TAAATATTGAACCTACCGAGTCACCAGTCAGTAAGTCTTTAAAGATTCATAGGGA

TGATTTCCCTAAATTTGTCAACTTCAAGCCTAAGGAACTAACCGAGTGGATCAAA

GACAGTAAAGGCAAAAAGTTAAAGAGCGGTATTGAGTCCCTGGAGATAGGTCTTA

GAGTCATGTCTATCGATTTGGGTCAAAGACAAGCAGCCGCAGCATCTATTTTCGA

AGTTGTTGACCAAAAACCGGATATCGAGGGGAAATTATTTTTTCCAATAAAAGGA

ACTGAGCTATACGCTGTGCATCGCGCATCCTTCAATATAAAACTGCCAGGAGAAA

CACTAGTAAAATCTAGAGAGGTCTTGCGTAAAGCACGTGAGGACAATCTCAAATT

AATGAATCAGAAGTTAAATTTCCTTAGGAACGTGTTGCATTTCCAACAGTTCGAG

GACATAACTGAACGCGAGAAAAGAGTCACTAAGTGGATCTCAAGACAAGAAAATA

GTGATGTGCCATTAGTGTATCAAGACGAACTTATTCAAATAAGAGAGCTAATGTA

TAAACCATATAAAGACTGGGTGGCATTCTTAAAACAATTACACAAGCGGCTTGAA

GTAGAAATAGGAAAAGAAGTAAAGCATTGGAGGAAGAGTCTGTCCGATGGTCGCA

AAGGCCTGTACGGGATATCACTTAAAAATATTGATGAAATTGACAGAACACGAAA

ATTTTTGTTAAGATGGTCATTGAGACCAACCGAACCAGGTGAGGTTAGAAGGTTG

GAACCAGGCCAAAGGTTTGCCATCGATCAATTAAACCATCTTAACGCACTGAAAG

AAGATAGATTGAAGAAGATGGCGAACACTATTATTATGCACGCTCTAGGTTATTG

CTATGATGTGAGAAAGAAAAAATGGCAAGCCAAGAACCCTGCATGCCAAATTATT

TTGTTTGAAGATCTTTCTAATTACAATCCATACGAAGAGCGTTCACGTTTTGAAA

ACTCTAAATTGATGAAATGGTCTAGAAGAGAGATTCCGAGACAGGTCGCTCTACA

AGGGGAGATTTACGGTCTTCAAGTCGGTGAGGTTGGTGCTCAATTTTCTTCCAGA

TTTCATGCAAAAACTGGGTCTCCAGGCATTAGGTGTTCGGTCGTTACTAAGGAAA

AGTTACAGGACAACCGTTTCTTCAAAAATTTGCAACGTGAAGGCCGTTTAACACT

TGATAAGATAGCTGTCCTTAAGGAAGGCGATCTGTACCCAGATAAAGGTGGTGAG

AAATTCATATCTTTGAGTAAAGACAGGAAACTGGTTACAACACACGCCGACATTA

ACGCAGCTCAGAACTTGCAAAAGAGATTCTGGACAAGGACCCACGGCTTCTATAA

GGTGTACTGTAAAGCTTATCAAGTAGATGGACAAACGGTTTATATTCCTGAATCA

AAGGACCAGAAACAAAAAATTATAGAAGAATTTGGTGAAGGATACTTTATCTTGA

AGGATGGAGTTTATGAGTGGGGCAATGCAGGTAAGTTAAAGATAAAGAAAGGTTC

ATCAAAGCAATCAAGTAGCGAACTGGTCGATTCGGATATTTTAAAGGATAGCTTT

GATCTAGCTAGTGAATTGAAGGGAGAAAAGTTAATGTTATACAGAGATCCCAGTG

GGAATGTATTTCCATCTGATAAGTGGATGGCCGCCGGAGTGTTTTTTGGCAAATT

AGAGAGAATCTTGATTTCTAAACTGACCAATCAATACTCAATTTCGACCATCGAA

GACGACTCTTCAAAACAATCCATGTGA

SEQ
ATGCCTACTCGCACCATCAATCTGAAGTTAGTTTTGGGGAAGAACCCAGAAAATG

ID
CGACTCTAAGACGGGCACTATTCTCTACACATAGACTTGTCAACCAAGCGACTAA

NO:
GAGAATTGAAGAATTTTTACTGTTGTGTAGAGGAGAAGCTTATCGTACCGTAGAT

141
AATGAAGGTAAAGAAGCTGAGATCCCACGCCATGCTGTTCAAGAAGAGGCGCTTG

CTTTTGCAAAAGCTGCACAACGACATAACGGCTGTATCTCCACATATGAGGACCA

GGAAATCTTGGATGTGCTTAGACAATTGTATGAAAGATTAGTACCTAGCGTCAAT

GAAAACAACGAGGCTGGGGATGCCCAAGCCGCTAACGCTTGGGTGAGTCCATTAA

TGAGTGCAGAGTCCGAAGGTGGACTATCGGTCTATGATAAAGTGTTAGACCCGCC

GCCAGTATGGATGAAACTCAAAGAAGAGAAAGCGCCTGGTTGGGAAGCTGCTTCT

CAGATTTGGATACAGTCCGACGAAGGTCAATCGCTGCTAAATAAACCGGGTAGCC

CACCACGTTGGATTAGAAAACTTAGATCTGGTCAACCGTGGCAAGATGACTTCGT

TTCAGACCAAAAAAAAAAGCAAGATGAACTAACGAAAGGTAACGCACCACTCATA

AAACAATTGAAAGAGATGGGCCTCTTGCCTTTAGTTAATCCCTTTTTTAGACATT

TGTTGGATCCCGAGGGTAAGGGTGTATCCCCATGGGACAGATTGGCCGTAAGGGC

CGCGGTGGCGCACTTCATCTCTTGGGAAAGTTGGAACCACAGAACAAGAGCTGAG

TATAACAGTTTGAAACTGCGAAGAGATGAATTTGAGGCCGCATCTGATGAATTCA

AGGACGATTTTACATTGCTACGACAATATGAGGCTAAGCGACATAGTACGCTTAA

GTCAATTGCCTTAGCTGATGACTCTAACCCGTACCGAATTGGTGTAAGGTCCTTG

AGAGCCTGGAATAGGGTTAGAGAAGAATGGATTGACAAAGGCGCAACCGAGGAAC

AAAGGGTTACCATCCTTAGTAAGCTTCAAACACAATTACGGGGTAAATTCGGTGA

TCCAGACCTATTTAATTGGCTAGCCCAAGATAGACACGTACACCTGTGGTCCCCG

AGAGATTCCGTCACGCCCCTCGTAAGGATTAATGCCGTCGACAAAGTGCTTAGAA

GACGTAAGCCTTATGCACTGATGACTTTTGCACATCCGAGATTCCATCCAAGATG

GATTCTATACGAAGCGCCTGGTGGTTCTAACTTGCGACAATACGCTTTAGATTGT

ACTGAAAATGCTCTGCATATTACACTTCCATTACTCGTCGACGACGCCCATGGTA

CATGGATTGAGAAAAAAATCCGCGTACCACTCGCTCCTAGTGGACAAATACAAGA

TTTAACTTTAGAAAAACTTGAAAAGAAAAAAAACAGATTATACTATAGATCAGGA

TTCCAACAATTTGCTGGATTAGCCGGTGGTGCTGAGGTGTTGTTTCATAGGCCGT

ATATGGAACATGATGAGAGATCAGAAGAATCTCTGTTGGAAAGGCCAGGCGCTGT

GTGGTTCAAATTAACCTTAGATGTTGCTACCCAAGCACCACCTAACTGGTTAGAT

GGTAAAGGCAGAGTTAGGACACCTCCAGAAGTTCATCATTTCAAAACCGCTCTGT

CAAATAAATCTAAACATACGAGAACCTTGCAACCAGGATTGAGAGTCCTTTCTGT

TGATTTGGGTATGAGAACATTTGCTTCTTGTTCTGTTTTCGAATTGATCGAAGGT

AAACCTGAAACAGGTAGAGCATTCCCTGTTGCTGACGAAAGATCAATGGATAGTC

CAAATAAGTTATGGGCCAAGCACGAGAGAAGCTTTAAACTAACTCTGCCTGGAGA

AACACCGAGCAGAAAGGAGGAAGAAGAGAGAAGCATTGCTAGGGCAGAGATTTAC

GCGCTGAAAAGAGATATTCAAAGACTGAAATCACTCCTAAGATTAGGTGAGGAAG

ATAATGATAATAGAAGAGATGCTTTGTTAGAGCAATTCTTTAAAGGATGGGGTGA

AGAGGACGTAGTTCCTGGTCAAGCTTTCCCTAGAAGCCTCTTTCAGGGATTAGGC

GCTGCACCCTTTAGGTCAACACCCGAATTGTGGAGACAGCACTGTCAGACGTATT

ACGACAAAGCGGAAGCTTGCCTGGCAAAGCATATTTCCGACTGGAGGAAGAGAAC

TAGACCTCGTCCGACTTCGAGAGAGATGTGGTATAAGACAAGATCTTACCATGGT

GGCAAAAGTATTTGGATGCTAGAATACTTAGATGCTGTCCGCAAATTACTACTTT

CATGGTCGTTAAGAGGTCGTACTTACGGAGCTATTAATAGACAAGACACCGCTCG

TTTTGGTTCCTTAGCTTCTAGATTGTTGCATCATATCAACTCTTTAAAGGAAGAC

CGCATCAAAACCGGTGCAGATAGTATTGTGCAGGCCGCAAGGGGCTATATTCCTC

TCCCACATGGCAAGGGTTGGGAACAGCGTTATGAACCCTGTCAGTTGATATTATT

TGAAGATCTAGCTAGGTACAGATTTCGTGTAGACAGACCTCGGAGAGAGAATTCG

CAATTGATGCAGTGGAATCATCGAGCTATAGTAGCAGAAACGACGATGCAAGCTG

AACTATACGGTCAAATAGTCGAAAATACCGCTGCTGGTTTCTCCTCAAGATTTCA

TGCTGCAACTGGTGCTCCTGGTGTCAGATGTCGCTTTTTGTTAGAACGAGATTTC

GATAATGACCTACCAAAGCCGTACTTACTGAGAGAACTAAGTTGGATGTTAGGTA

ACACAAAGGTTGAATCAGAGGAAGAAAAATTGCGTCTTCTAAGCGAGAAAATTAG

ACCAGGTTCATTAGTCCCTTGGGATGGGGGTGAACAATTCGCGACATTACACCCG

AAAAGACAAACTCTTTGTGTCATTCACGCAGATATGAACGCTGCTCAAAACCTGC

AACGCAGATTTTTCGGAAGGTGTGGGGAAGCCTTTCGCCTTGTGTGTCAGCCACA

TGGTGATGATGTTTTGAGGCTAGCGTCTACACCAGGTGCAAGACTTTTGGGTGCA

TTACAACAACTGGAAAATGGTCAGGGAGCTTTCGAATTAGTTCGTGATATGGGTA

GCACATCACAAATGAATCGTTTCGTCATGAAGTCGTTGGGCAAAAAAAAGATCAA

GCCATTACAAGACAATAACGGGGATGATGAACTAGAAGACGTGCTATCTGTTTTA

CCTGAAGAAGATGATACCGGACGAATTACTGTATTTCGGGACTCTTCGGGTATAT

TCTTCCCTTGTAACGTTTGGATCCCGGCAAAACAGTTCTGGCCTGCGGTCCGTGC

TATGATTTGGAAGGTTATGGCATCACATTCATTGGGTTAG

SEQ
ATGACAAAGTTAAGGCATAGACAGAAGAAGTTAACTCACGATTGGGCGGGGTCTA

ID
AAAAGAGAGAAGTTCTAGGGAGCAATGGTAAATTACAGAATCCATTGCTAATGCC

NO:
CGTCAAAAAAGGTCAGGTGACAGAATTTCGAAAAGCATTTTCCGCATACGCCCGA

142
GCAACCAAAGGGGAAATGACGGATGGCAGAAAAAATATGTTTACTCACTCATTTG

AACCATTCAAGACCAAGCCTTCGTTACATCAGTGCGAACTGGCTGACAAAGCCTA

CCAGAGCTTGCATTCATATTTACCGGGTTCTTTGGCGCATTTTCTTTTATCTGCC

CATGCACTTGGTTTTAGGATTTTTAGCAAATCAGGGGAAGCCACTGCATTCCAAG

CGTCCTCAAAGATTGAAGCTTACGAAAGCAAGTTAGCTAGCGAGCTTGCTTGTGT

TGATTTGTCTATTCAGAACTTGACTATTTCAACTTTGTTCAACGCATTAACGACT

TCCGTAAGAGGTAAAGGTGAGGAGACATCGGCAGATCCACTGATAGCTAGATTTT

ACACCTTACTTACCGGTAAACCACTAAGCAGAGACACTCAGGGCCCAGAACGAGA

TTTAGCCGAGGTGATAAGCAGAAAAATTGCAAGTTCTTTTGGAACTTGGAAGGAG

ATGACTGCCAATCCACTTCAATCTCTTCAATTTTTTGAAGAGGAGTTGCATGCGC

TAGATGCAAATGTTAGTTTGTCACCTGCCTTCGATGTTCTGATTAAGATGAACGA

CCTGCAGGGTGACTTGAAGAACAGAACGATAGTTTTTGATCCAGATGCTCCTGTG

TTTGAATATAATGCTGAGGATCCTGCTGACATCATCATTAAACTGACAGCTAGAT

ATGCGAAAGAAGCAGTGATTAAAAATCAAAATGTCGGGAATTATGTTAAGAACGC

TATTACGACAACTAACGCAAACGGACTAGGTTGGTTGCTGAACAAAGGCCTTTCC

TTATTGCCTGTCTCCACTGATGACGAACTATTGGAGTTTATTGGGGTCGAGAGAT

CCCATCCTAGCTGTCATGCGTTGATAGAACTTATCGCTCAGTTAGAAGCACCTGA

ACTGTTCGAAAAAAATGTTTTTTCTGATACTCGTTCCGAGGTTCAAGGTATGATA

GATTCAGCTGTAAGCAATCATATCGCCAGGCTGTCAAGCTCTCGTAATTCATTGA

GCATGGACTCAGAGGAACTTGAGAGATTGATAAAATCTTTTCAAATTCATACACC

ACATTGTTCATTATTTATAGGGGCTCAATCCTTATCTCAACAATTGGAAAGCCTA

CCCGAAGCATTGCAGTCAGGAGTGAACAGTGCTGATATTCTGCTCGGCTCAACCC

AATACATGTTGACAAATTCTTTGGTCGAGGAGTCAATCGCTACGTATCAGAGAAC

CTTAAATAGAATTAACTACCTGTCCGGCGTTGCAGGACAGATTAACGGTGCTATT

AAGAGGAAAGCTATTGATGGTGAGAAGATACATTTACCCGCTGCTTGGTCAGAGT

TAATTTCTTTACCCTTTATTGGGCAACCAGTGATTGATGTTGAATCAGATTTAGC

CCACTTAAAGAACCAATACCAGACATTGTCTAACGAATTTGATACGCTGATTTCC

GCACTGCAAAAGAATTTCGACTTAAATTTTAATAAAGCCTTGCTTAATCGAACAC

AACATTTCGAGGCTATGTGTAGATCAACAAAAAAGAATGCCCTTTCTAAGCCTGA

GATCGTTAGTTATAGAGATTTGCTAGCCAGGTTGACTTCTTGTCTTTATAGGGGC

TCTCTAGTCTTGAGGAGGGCGGGTATAGAAGTACTGAAAAAGCACAAGATATTTG

AGTCCAACTCTGAATTAAGAGAGCACGTTCATGAAAGAAAACACTTCGTATTTGT

TTCTCCGCTCGATAGAAAAGCCAAGAAGCTCCTACGTTTGACTGACTCTAGGCCT

GATTTATTGCACGTAATTGATGAAATACTACAACATGATAATTTAGAGAACAAGG

ATAGAGAATCTTTGTGGTTAGTTCGATCTGGTTATTTACTGGCCGGCCTACCAGA

CCAACTCTCCTCTTCCTTTATAAATCTTCCAATCATTACTCAAAAAGGCGATCGT

CGCTTGATAGATCTCATTCAATACGACCAAATTAATAGAGATGCTTTTGTGATGT

TGGTAACTTCCGCTTTTAAGTCGAACTTAAGTGGGCTGCAGTACAGAGCAAACAA

ACAATCTTTTGTGGTTACGCGCACTTTGTCACCATATTTGGGATCTAAATTGGTT

TATGTGCCCAAAGATAAAGATTGGCTGGTCCCTTCCCAAATGTTCGAGGGGAGAT

TTGCGGACATTTTGCAATCCGATTATATGGTGTGGAAGGACGCTGGAAGATTGTG

TGTTATTGACACAGCTAAGCATTTGTCTAACATTAAAAAATCTGTATTCTCAAGT

GAAGAAGTCCTCGCGTTTTTAAGAGAATTGCCACACCGTACGTTTATCCAAACTG

AGGTCAGGGGTTTAGGGGTGAATGTGGACGGTATTGCATTTAATAACGGGGATAT

ACCCTCTCTGAAGACGTTTAGCAATTGCGTGCAAGTCAAAGTGAGTCGGACAAAC

ACTAGTCTGGTCCAAACATTAAATAGATGGTTTGAAGGCGGTAAGGTCTCGCCGC

CTAGCATCCAATTTGAGAGAGCATATTACAAAAAAGATGATCAAATCCACGAGGA

CGCTGCAAAAAGGAAGATAAGGTTTCAAATGCCAGCTACAGAGTTGGTACACGCG

TCAGACGACGCAGGATGGACCCCCTCCTATTTACTTGGTATCGATCCCGGTGAAT

ATGGTATGGGTTTGTCATTGGTCTCAATAAATAATGGCGAAGTTTTAGATAGCGG

ATTTATACACATAAATTCATTGATAAATTTCGCTTCTAAGAAATCAAATCATCAA

ACCAAAGTTGTTCCGAGGCAGCAATACAAGTCACCATACGCCAACTATCTAGAAC

AATCTAAAGATTCTGCAGCAGGAGACATAGCTCATATTTTGGATAGACTTATCTA

CAAGTTGAACGCCCTACCCGTTTTCGAAGCTCTATCTGGCAATAGTCAAAGCGCA

GCGGATCAGGTTTGGACAAAAGTCCTCAGCTTCTACACCTGGGGAGATAATGATG

CACAAAATTCAATTCGTAAGCAACATTGGTTCGGTGCTTCACACTGGGACATTAA

AGGCATGTTGAGGCAACCGCCAACAGAAAAAAAGCCCAAACCATACATTGCCTTT

CCCGGTTCACAAGTTTCTTCTTATGGTAATTCTCAAAGGTGTTCATGTTGTGGAC

GTAACCCAATTGAACAATTGCGCGAAATGGCGAAGGACACATCCATTAAGGAGTT

GAAGATTAGAAATTCAGAAATTCAATTGTTCGACGGTACTATAAAGTTATTTAAT

CCAGACCCGTCAACGGTCATAGAAAGAAGAAGACATAATTTAGGGCCATCAAGAA

TTCCTGTAGCTGATAGAACTTTCAAAAATATAAGTCCAAGCTCACTAGAATTCAA

AGAACTAATAACGATTGTGTCACGGTCTATACGTCATTCCCCAGAATTTATTGCT

AAAAAAAGAGGTATAGGTAGTGAGTACTTTTGTGCTTATAGTGATTGTAATTCCT

CCTTAAATTCAGAAGCAAATGCGGCTGCGAACGTTGCCCAAAAGTTCCAAAAGCA

ATTGTTTTTCGAATTATAG

SEQ
ATGAAAAGAATCTTGAACTCTTTAAAGGTTGCCGCCCTGCGTTTGTTATTTAGAG

ID
GTAAAGGATCTGAACTTGTCAAGACTGTTAAATACCCTTTGGTCTCGCCGGTTCA

NO:
GGGTGCAGTTGAGGAGTTAGCTGAGGCGATCCGCCATGATAACCTACATCTGTTT

143
GGTCAAAAAGAAATTGTTGACCTTATGGAAAAGGATGAAGGTACGCAAGTTTACT

CAGTGGTTGATTTCTGGTTAGATACCCTTCGTTTGGGGATGTTTTTCAGTCCATC

AGCAAACGCATTAAAAATCACGCTGGGTAAGTTTAATTCTGATCAGGTTAGCCCT

TTTAGGAAAGTGTTAGAGCAGTCTCCATTCTTCTTGGCTGGTAGGCTGAAGGTTG

AACCGGCAGAACGTATATTATCTGTCGAGATCCGTAAGATTGGGAAGAGGGAAAA

CAGAGTTGAGAACTATGCTGCTGACGTAGAAACGTGTTTTATAGGCCAATTAAGT

TCAGATGAGAAACAGTCAATACAAAAATTAGCTAATGATATCTGGGATAGTAAAG

ATCATGAAGAGCAAAGAATGTTAAAGGCAGATTTCTTCGCTATCCCTTTGATTAA

GGATCCAAAGGCTGTGACCGAAGAGGATCCTGAAAATGAAACTGCTGGTAAACAA

AAACCCTTGGAGTTGTGTGTCTGCCTTGTCCCAGAACTTTACACAAGAGGATTCG

GGTCAATAGCCGATTTTTTGGTTCAACGCTTAACTCTTTTAAGGGATAAAATGTC

TACAGATACTGCAGAAGATTGTTTAGAATATGTCGGGATTGAGGAGGAAAAAGGT

AACGGCATGAACTCATTGTTGGGAACGTTCTTAAAGAATTTGCAAGGCGATGGAT

TTGAGCAGATTTTCCAATTTATGTTAGGGAGCTATGTCGGTTGGCAAGGGAAGGA

AGATGTTTTAAGAGAGAGATTAGACTTATTGGCTGAAAAAGTGAAGAGGTTACCG

AAACCAAAATTTGCTGGCGAATGGTCTGGTCATAGGATGTTCTTGCATGGCCAAT

TGAAGTCTTGGTCTTCAAATTTTTTTAGACTATTTAACGAGACAAGGGAACTTCT

AGAGTCTATTAAGTCAGATATACAGCATGCCACAATGCTAATATCATATGTAGAA

GAAAAAGGTGGTTATCATCCTCAATTACTTAGTCAATATAGAAAACTTATGGAAC

AACTACCAGCTTTGCGTACCAAGGTATTGGACCCTGAGATTGAAATGACACATAT

GTCCGAAGCAGTTCGCTCTTATATAATGATACATAAATCTGTTGCGGGTTTTTTA

CCGGATTTATTAGAATCATTAGATAGAGACAAGGATCGTGAGTTTCTGCTTAGTA

TTTTTCCAAGAATCCCAAAAATTGATAAAAAAACCAAGGAAATTGTAGCTTGGGA

ACTGCCGGGAGAACCAGAAGAAGGTTATTTATTTACTGCTAATAACTTGTTCAGA

AACTTCTTAGAGAATCCGAAACATGTCCCGAGATTTATGGCCGAAAGGATCCCAG

AAGATTGGACTCGATTACGCTCTGCTCCTGTCTGGTTCGATGGAATGGTAAAACA

ATGGCAAAAAGTCGTTAACCAGTTAGTAGAATCACCAGGTGCTTTATATCAATTT

AACGAATCCTTCTTGAGACAAAGGTTACAGGCCATGTTAACTGTGTATAAGAGGG

ACTTACAAACTGAAAAATTTCTTAAACTTTTGGCGGATGTTTGTAGGCCTCTTGT

AGATTTTTTTGGTTTGGGTGGAAATGATATTATTTTTAAGAGCTGTCAAGACCCA

AGAAAACAATGGCAAACCGTTATTCCTCTCTCTGTTCCGGCAGATGTCTATACTG

CTTGCGAAGGTTTGGCGATTAGACTAAGGGAGACATTAGGATTCGAATGGAAGAA

TTTGAAAGGTCACGAGAGAGAAGATTTCTTAAGATTGCACCAGTTATTGGGCAAT

TTACTTTTCTGGATTCGTGATGCTAAATTGGTAGTAAAATTAGAGGATTGGATGA

ACAACCCATGTGTTCAGGAATATGTAGAAGCCCGGAAAGCTATCGATCTTCCACT

AGAAATATTCGGTTTTGAAGTGCCTATCTTCCTGAATGGCTATCTATTTTCGGAG

TTGAGACAATTAGAACTTTTGCTTAGGAGAAAAAGTGTGATGACTAGCTACAGTG

TAAAGACTACTGGATCTCCTAATAGGCTATTTCAGCTAGTTTATTTACCTCTAAA

CCCTAGTGACCCCGAAAAGAAGAACTCAAATAACTTTCAAGAACGTTTGGATACC

CCAACTGGTTTGTCCCGTCGTTTCCTAGACCTAACCCTTGATGCATTCGCAGGTA

AGTTACTTACCGATCCAGTTACACAAGAATTGAAGACAATGGCAGGTTTTTACGA

TCATCTTTTTGGATTCAAATTGCCATGTAAACTCGCCGCCATGTCGAATCATCCA

GGTTCTTCTTCAAAGATGGTTGTGTTAGCGAAACCCAAAAAAGGTGTTGCTTCTA

ATATAGGGTTTGAACCGATCCCAGATCCCGCTCATCCCGTATTTAGGGTTAGATC

CAGTTGGCCAGAGTTGAAGTACCTCGAGGGGCTATTGTATTTGCCAGAAGACACA

CCTTTGACCATCGAATTAGCAGAGACCTCCGTATCGTGCCAAAGTGTCTCGTCAG

TTGCATTCGATTTGAAAAACTTGACAACGATCTTAGGTCGTGTGGGAGAATTTAG

GGTCACAGCTGATCAACCCTTTAAACTAACGCCTATAATCCCGGAGAAAGAAGAA

TCTTTTATTGGTAAAACTTATTTGGGTCTCGACGCGGGTGAAAGGAGCGGCGTCG

GTTTCGCTATTGTTACAGTGGACGGAGATGGGTACGAAGTGCAAAGATTGGGGGT

CCACGAGGATACACAGCTTATGGCCTTGCAGCAAGTTGCTAGTAAATCCTTAAAA

GAGCCAGTATTTCAGCCTCTAAGAAAAGGCACCTTTAGACAACAAGAAAGAATAC

GGAAATCCTTACGTGGTTGCTACTGGAATTTTTATCATGCCTTGATGATAAAATA

TAGGGCCAAAGTAGTACATGAGGAATCTGTCGGAAGTAGTGGTCTTGTGGGTCAA

TGGTTGAGGGCTTTTCAGAAGGATTTGAAGAAAGCCGATGTTCTCCCCAAGAAGG

GCGGTAAAAACGGTGTAGATAAGAAGAAGAGAGAGTCCTCAGCTCAAGACACTCT

TTGGGGTGGTGCTTTCTCTAAAAAGGAGGAGCAACAGATTGCGTTTGAGGTGCAA

GCTGCAGGTTCTTCGCAATTTTGTTTGAAGTGCGGATGGTGGTTCCAACTAGGCA

TGCGTGAAGTAAACAGGGTACAAGAATCGGGCGTCGTGTTAGATTGGAATAGAAG

CATAGTTACCTTTTTAATAGAATCATCCGGCGAAAAAGTTTATGGTTTCTCCCCA

CAGCAATTAGAGAAGGGTTTCAGACCAGACATCGAAACTTTTAAAAAGATGGTAA

GAGACTTTATGAGACCTCCTATGTTTGATAGAAAAGGCAGACCGGCCGCAGCTTA

CGAGAGATTTGTTTTAGGAAGGAGACATCGAAGGTACAGGTTTGATAAAGTATTT

GAGGAAAGATTTGGGAGGTCTGCTCTTTTCATTTGTCCTAGAGTAGGTTGTGGAA

ATTTTGACCACAGCTCCGAACAGTCCGCGGTTGTTTTGGCCTTGATCGGATATAT

TGCCGATAAGGAGGGAATGTCAGGTAAGAAGTTGGTTTATGTACGGCTGGCCGAA

CTTATGGCCGAATGGAAACTAAAAAAATTAGAAAGATCCAGAGTTGAAGAACAAT

CATCCGCTCAATAA

SEQ
ATGGCAGAAAGCAAACAAATGCAGTGTAGGAAATGTGGAGCTAGTATGAAGTACG

ID
AAGTCATCGGTTTGGGTAAAAAGTCATGTAGATACATGTGTCCCGATTGTGGCAA

NO:
CCATACCTCGGCAAGAAAGATACAAAACAAAAAAAAAAGAGATAAAAAATATGGG

144
TCAGCCAGTAAAGCCCAATCTCAAAGAATTGCTGTAGCAGGTGCTCTTTACCCTG

ACAAAAAAGTACAAACTATCAAAACCTATAAATATCCAGCAGACTTGAATGGTGA

GGTGCATGATAGCGGTGTTGCCGAGAAAATCGCACAAGCAATACAAGAGGACGAG

ATTGGACTTTTGGGACCAAGCTCAGAATATGCATGCTGGATTGCATCTCAAAAAC

AGTCTGAGCCTTACAGTGTAGTCGATTTCTGGTTTGATGCAGTGTGCGCAGGGGG

AGTCTTCGCCTACTCTGGCGCTAGATTATTGAGTACAGTTTTACAGTTATCCGGT

GAGGAATCGGTGCTTAGAGCTGCCTTAGCCTCGTCTCCATTCGTTGACGATATAA

ACTTAGCGCAAGCCGAAAAGTTTTTGGCGGTTAGCAGGCGTACAGGTCAAGATAA

GTTAGGTAAGAGAATTGGGGAGTGCTTTGCAGAAGGAAGATTGGAAGCTTTAGGG

ATAAAAGATAGAATGAGGGAATTTGTTCAAGCTATCGATGTTGCACAGACCGCCG

GACAACGTTTCGCTGCCAAATTGAAGATATTCGGTATAAGTCAGATGCCAGAAGC

TAAGCAATGGAATAACGATTCCGGACTGACTGTCTGTATACTACCTGATTATTAT

GTTCCCGAAGAGAATCGCGCGGACCAACTTGTAGTGTTGTTAAGAAGACTTCGCG

AGATTGCATATTGCATGGGTATTGAAGATGAAGCGGGTTTCGAACATCTTGGAAT

AGATCCTGGTGCTCTTTCGAATTTTTCAAACGGTAACCCTAAGAGAGGATTTCTA

GGGAGGCTGTTAAATAACGATATTATTGCGTTGGCAAACAATATGAGTGCGATGA

CTCCATATTGGGAAGGGCGTAAGGGTGAACTCATAGAAAGGCTTGCGTGGTTAAA

GCACAGGGCAGAAGGGCTGTATCTTAAAGAACCTCATTTCGGTAACTCCTGGGCC

GATCATAGGTCACGAATTTTCTCAAGGATCGCAGGCTGGTTATCTGGTTGCGCTG

GCAAGTTGAAAATTGCGAAAGACCAAATTTCTGGAGTACGTACAGATCTATTTCT

GCTAAAAAGACTGCTGGACGCAGTTCCGCAATCGGCGCCATCCCCCGATTTTATT

GCGTCAATTTCGGCACTTGACAGGTTTTTAGAAGCTGCAGAATCGAGCCAGGACC

CTGCTGAACAAGTGAGGGCTCTCTACGCTTTTCACTTGAACGCACCTGCAGTCCG

AAGTATAGCCAATAAAGCAGTGCAAAGGTCCGACAGCCAAGAATGGCTGATAAAA

GAACTAGACGCTGTTGACCATTTAGAATTTAACAAAGCGTTCCCATTTTTCTCTG

ACACAGGAAAAAAAAAAAAAAAAGGTGCTAATAGCAACGGTGCTCCATCGGAAGA

AGAGTACACTGAAACGGAATCAATACAACAACCTGAGGACGCGGAACAGGAAGTA

AACGGACAAGAAGGGAACGGAGCGTCTAAAAATCAAAAGAAATTTCAAAGAATAC

CTAGATTCTTCGGTGAAGGCTCCAGATCTGAATACAGAATTTTAACGGAAGCTCC

ACAGTATTTCGATATGTTTTGTAATAACATGAGGGCTATATTTATGCAGTTAGAA

AGTCAACCCCGTAAAGCTCCCAGAGATTTTAAATGTTTCCTACAAAATCGATTAC

AAAAATTATACAAACAGACTTTCTTGAATGCACGAAGCAACAAGTGTCGCGCTCT

GCTTGAGTCAGTTTTAATCTCTTGGGGAGAATTTTATACATACGGTGCCAACGAA

AAGAAATTTAGATTAAGACATGAAGCTTCAGAACGCAGCAGTGACCCAGATTACG

TAGTTCAGCAAGCCTTGGAAATCGCGCGTCGTCTATTCCTTTTTGGCTTCGAATG

GAGAGATTGCTCCGCTGGTGAAAGAGTGGATTTGGTTGAAATTCACAAAAAGGCT

ATCAGTTTTTTGTTGGCTATTACTCAAGCTGAGGTCTCTGTTGGTTCATACAATT

GGCTTGGCAACTCAACAGTATCGAGATATTTATCCGTTGCGGGAACTGATACCTT

ATACGGTACCCAATTGGAAGAATTCCTGAACGCTACAGTGTTGAGTCAAATGCGT

GGTCTGGCCATTAGATTGAGTTCTCAAGAACTTAAGGACGGTTTTGATGTGCAGC

TCGAGTCTTCCTGCCAGGACAATCTGCAACACCTATTGGTGTATAGGGCTTCGAG

AGATTTGGCGGCTTGCAAGCGCGCTACTTGTCCAGCCGAACTCGATCCTAAGATT

TTAGTTTTACCGGTAGGTGCATTCATCGCTTCCGTAATGAAAATGATAGAAAGAG

GTGACGAACCTTTAGCTGGTGCTTATTTACGGCATAGGCCACACTCTTTCGGATG

GCAAATTAGGGTCCGCGGTGTTGCTGAGGTAGGGATGGATCAGGGTACAGCATTG

GCCTTTCAAAAGCCAACAGAGTCAGAACCTTTTAAAATTAAGCCCTTCTCTGCAC

AGTATGGACCAGTTCTGTGGTTGAACAGTAGTAGTTATTCTCAATCACAATATTT

GGACGGTTTTCTATCTCAACCAAAAAATTGGAGTATGAGGGTGTTGCCTCAGGCG

GGTTCAGTTCGCGTCGAACAACGAGTTGCTTTGATATGGAACTTACAAGCAGGCA

AGATGAGACTAGAACGCTCCGGTGCGAGGGCCTTTTTCATGCCTGTACCGTTTTC

ATTTAGGCCATCCGGCAGTGGGGACGAAGCAGTTTTGGCGCCCAACCGGTACTTG

GGTCTGTTCCCTCATTCCGGAGGTATAGAATACGCTGTAGTGGATGTCCTGGATT

CTGCTGGATTTAAAATTCTTGAAAGAGGCACTATTGCTGTCAATGGTTTCTCTCA

GAAAAGGGGAGAGCGCCAAGAAGAAGCCCATCGTGAAAAACAAAGAAGGGGGATA

AGTGATATAGGGCGAAAGAAGCCTGTGCAGGCAGAAGTCGATGCGGCGAACGAAT

TGCATAGAAAGTACACTGATGTTGCCACAAGATTAGGTTGTAGAATCGTCGTTCA

ATGGGCACCACAACCTAAACCAGGGACAGCACCGACAGCGCAAACTGTTTACGCG

AGGGCTGTTAGGACAGAAGCTCCGAGGAGCGGCAACCAAGAAGATCATGCAAGAA

TGAAAAGTTCTTGGGGTTACACCTGGGGTACGTATTGGGAGAAACGAAAACCAGA

AGATATTTTAGGGATTTCTACACAGGTGTATTGGACAGGAGGTATAGGCGAATCC

TGTCCTGCTGTAGCAGTCGCTTTATTAGGTCATATTAGAGCAACTTCAACACAAA

CGGAGTGGGAAAAGGAAGAAGTTGTCTTTGGAAGACTGAAGAAGTTCTTTCCGAG

TTAA

SEQ
ATGGAGAAGAGAATTAATAAGATACGGAAAAAATTATCTGCGGATAATGCAACAA

ID
AGCCAGTCTCTCGTTCAGGCCCCATGAAAACCCTGCTTGTAAGAGTAATGACGGA

NO:
TGATTTAAAAAAGAGGTTGGAAAAGCGTAGAAAAAAACCAGAAGTGATGCCGCAA

145
GTGATCTCAAATAACGCAGCTAATAATCTAAGGATGCTACTTGATGATTATACAA

AAATGAAAGAAGCAATCCTGCAAGTTTACTGGCAGGAATTCAAGGATGACCATGT

TGGACTAATGTGCAAATTCGCACAACCAGCGTCTAAGAAAATTGACCAAAATAAA

TTGAAACCCGAAATGGACGAAAAAGGGAATTTAACAACTGCCGGGTTTGCCTGCT

CGCAATGTGGGCAACCATTATTTGTTTATAAATTAGAGCAGGTTTCGGAAAAAGG

AAAGGCTTACACAAATTACTTCGGCAGATGTAATGTTGCCGAACACGAAAAACTC

ATATTGTTAGCTCAGTTGAAGCCTGAGAAAGACTCTGATGAGGCCGTTACTTACT

CGTTGGGGAAGTTTGGTCAAAGAGCTCTCGATTTTTATTCTATTCATGTGACAAA

GGAGTCCACACATCCCGTCAAGCCCTTGGCACAAATTGCGGGTAATAGATACGCT

TCGGGTCCAGTTGGGAAGGCCCTTTCTGATGCATGTATGGGCACAATTGCTAGCT

TTCTTAGTAAATACCAGGATATCATAATAGAGCATCAAAAAGTTGTAAAGGGTAA

CCAAAAGAGATTAGAATCGCTGCGTGAGTTGGCGGGTAAAGAAAACTTGGAATAT

CCATCTGTCACTCTGCCTCCTCAACCTCATACTAAGGAAGGTGTAGATGCGTACA

ATGAAGTTATCGCTAGAGTCCGTATGTGGGTGAATTTAAATTTGTGGCAAAAATT

GAAGTTATCGCGTGATGATGCAAAACCTCTTCTTAGACTAAAGGGCTTTCCTAGC

TTCCCTGTAGTGGAAAGACGCGAAAATGAAGTCGATTGGTGGAATACAATTAACG

AAGTCAAAAAACTGATCGATGCAAAGCGAGATATGGGTCGAGTTTTTTGGTCTGG

TGTTACAGCTGAAAAAAGGAATACGATCTTAGAAGGTTACAACTACTTGCCAAAT

GAGAACGATCATAAAAAAAGAGAAGGCAGTTTAGAAAATCCAAAAAAGCCAGCTA

AGAGACAATTTGGTGATTTGCTACTTTACCTAGAAAAAAAGTACGCCGGAGATTG

GGGGAAAGTCTTTGACGAAGCTTGGGAGAGAATAGATAAAAAAATAGCAGGATTG

ACGTCACACATTGAAAGAGAAGAGGCGAGAAATGCAGAAGATGCTCAGTCCAAAG

CTGTCCTCACCGACTGGTTGAGAGCCAAAGCGTCCTTTGTTCTCGAACGCCTAAA

AGAAATGGATGAGAAGGAATTTTATGCCTGCGAAATCCAGCTACAAAAATGGTAC

GGAGACTTGAGAGGTAACCCCTTTGCCGTGGAAGCAGAGAACCGTGTTGTAGATA

TCTCCGGTTTCTCAATCGGTAGCGATGGACACTCCATTCAGTATCGCAACTTGTT

GGCCTGGAAATATTTGGAAAACGGTAAGAGGGAATTCTATTTACTTATGAATTAT

GGCAAGAAAGGTAGAATCAGGTTTACTGACGGAACAGACATTAAAAAGAGTGGTA

AGTGGCAAGGCCTTTTGTACGGTGGTGGCAAGGCCAAAGTAATAGACTTAACATT

TGACCCCGACGACGAACAACTGATAATACTGCCTTTAGCTTTTGGTACTCGACAG

GGGCGAGAGTTCATTTGGAATGATCTTTTGTCACTCGAGACTGGTTTGATAAAAC

TTGCAAATGGAAGAGTCATCGAGAAGACAATTTACAACAAAAAGATAGGTCGCGA

TGAGCCTGCACTATTTGTGGCCTTGACCTTTGAGAGAAGGGAAGTTGTCGACCCA

TCCAATATTAAACCAGTCAACCTAATCGGTGTAGATAGAGGTGAAAACATCCCAG

CTGTTATCGCTCTGACAGACCCTGAAGGTTGCCCTTTGCCAGAATTTAAAGATTC

GTCTGGTGGACCAACAGATATATTACGTATTGGGGAAGGCTATAAAGAGAAACAA

CGTGCTATTCAGGCTGCAAAAGAAGTTGAACAGAGGAGAGCTGGAGGTTACAGTA

GAAAATTCGCCAGTAAAAGTAGAAACTTAGCAGATGACATGGTTAGAAACTCTGC

CCGGGATTTGTTCTATCATGCGGTTACTCACGATGCAGTCTTAGTCTTTGAAAAT

CTATCGCGCGGTTTTGGTAGGCAAGGCAAGAGGACTTTTATGACAGAGAGACAAT

ATACAAAAATGGAAGATTGGTTAACCGCGAAGCTCGCATATGAAGGTCTTACTTC

GAAAACGTACCTCAGCAAAACGCTGGCTCAATATACTTCTAAAACTTGTTCAAAT

TGTGGTTTTACTATTACCACGGCAGACTACGACGGGATGTTGGTGAGATTGAAGA

AGACGAGCGATGGTTGGGCAACAACATTGAATAATAAGGAATTAAAAGCAGAAGG

ACAGATTACGTATTACAATCGTTATAAACGCCAAACGGTTGAGAAAGAGTTGTCA

GCCGAGTTGGATAGACTAAGTGAAGAGAGCGGTAACAATGATATCTCAAAGTGGA

CTAAAGGGAGGCGGGATGAAGCCCTCTTTTTACTAAAGAAGAGATTCTCACATAG

ACCTGTGCAAGAACAATTCGTTTGTTTAGATTGTGGCCATGAGGTTCATGCAGAC

GAACAGGCTGCGTTAAATATTGCGAGAAGCTGGCTATTTCTAAATTCTAATTCAA

CAGAGTTCAAGAGCTATAAATCCGGAAAACAACCTTTCGTAGGCGCGTGGCAAGC

CTTCTATAAAAGGAGATTAAAAGAGGTTTGGAAACCAAATGCA

SEQ
ATGAAAAGAATTAACAAAATTAGAAGGAGGCTGGTCAAAGATTCTAATACCAAGA

ID
AAGCTGGTAAGACTGGTCCGATGAAAACCCTATTAGTCAGAGTTATGACCCCAGA

NO:
TTTGAGAGAAAGATTGGAGAACCTCAGGAAAAAGCCCGAAAACATCCCACAACCC

146
ATTAGTAACACATCAAGAGCTAATTTAAACAAGTTATTAACTGACTACACTGAAA

TGAAAAAAGCAATATTGCATGTTTACTGGGAAGAGTTCCAGAAAGATCCTGTTGG

GTTGATGTCTAGAGTTGCTCAACCGGCCCCAAAGAATATAGATCAAAGGAAACTT

ATTCCTGTGAAGGACGGCAATGAAAGATTAACCAGCTCCGGTTTCGCTTGCTCCC

AGTGCTGCCAACCCCTGTATGTATACAAACTGGAACAAGTAAATGATAAAGGTAA

GCCACATACTAACTACTTTGGTAGGTGTAATGTATCCGAGCATGAAAGATTGATC

TTGTTAAGTCCCCATAAACCAGAAGCTAATGATGAGTTAGTAACTTATAGTTTAG

GTAAGTTCGGACAACGAGCTTTAGATTTCTATAGCATCCATGTTACAAGAGAAAG

CAATCACCCCGTCAAACCACTGGAACAAATCGGTGGTAATAGTTGTGCGTCAGGT

CCAGTAGGCAAAGCTTTATCAGACGCTTGCATGGGTGCCGTGGCTAGTTTTTTGA

CGAAATACCAAGATATTATACTGGAACATCAAAAGGTAATTAAAAAGAATGAAAA

GAGACTCGCTAACTTAAAAGATATTGCAAGTGCCAATGGTTTAGCTTTTCCTAAA

ATTACCTTGCCACCTCAGCCACATACAAAGGAGGGAATTGAAGCTTACAATAATG

TAGTAGCCCAAATAGTTATTTGGGTGAACCTTAACCTATGGCAAAAGTTAAAAAT

TGGTAGAGACGAAGCCAAACCCCTGCAGAGGCTGAAGGGTTTTCCCTCCTTCCCC

TTAGTAGAGAGACAAGCTAATGAAGTGGACTGGTGGGATATGGTGTGCAATGTTA

AAAAATTGATTAATGAGAAGAAAGAGGATGGTAAAGTGTTTTGGCAGAATCTTGC

TGGCTACAAGAGACAGGAAGCTTTACTGCCTTATTTATCTTCTGAGGAAGATAGG

AAAAAAGGTAAAAAATTTGCTAGATATCAATTCGGAGACCTACTTCTGCATTTAG

AAAAAAAACATGGCGAAGATTGGGGTAAAGTTTATGATGAAGCCTGGGAAAGAAT

TGATAAGAAGGTAGAAGGTCTCTCCAAACATATTAAATTAGAGGAAGAACGTAGG

TCCGAAGACGCTCAATCAAAGGCAGCATTAACTGATTGGTTGAGAGCAAAAGCCT

CTTTCGTTATTGAAGGATTAAAAGAAGCCGACAAAGATGAATTTTGTAGATGTGA

GTTAAAGTTGCAAAAGTGGTATGGAGACCTCCGTGGTAAACCTTTTGCTATTGAG

GCTGAAAATTCTATACTCGATATCTCTGGATTTTCAAAACAATATAACTGCGCAT

TTATATGGCAGAAAGATGGTGTTAAAAAGCTAAATCTATACTTAATTATCAATTA

CTTTAAAGGTGGTAAATTGCGTTTTAAGAAGATAAAGCCTGAAGCCTTTGAGGCA

AACCGTTTTTACACTGTTATCAATAAAAAATCTGGGGAAATCGTACCAATGGAAG

TTAATTTCAATTTCGATGATCCTAATCTTATTATTTTACCTCTTGCTTTCGGCAA

AAGGCAAGGTAGGGAGTTTATTTGGAATGATTTATTGTCGCTGGAAACGGGGTCT

CTCAAACTCGCAAACGGTAGGGTGATAGAAAAAACATTATACAACAGGAGAACTC

GGCAGGATGAGCCAGCTCTTTTTGTGGCTCTGACATTCGAGAGAAGGGAAGTTTT

AGATTCATCTAACATCAAACCAATGAATTTAATAGGTATTGACCGGGGTGAAAAT

ATACCTGCAGTTATTGCTTTAACTGATCCTGAGGGATGTCCTCTTAGCAGATTCA

AGGACTCGTTGGGTAACCCTACTCACATCTTAAGGATTGGAGAAAGTTACAAGGA

GAAACAAAGGACAATACAAGCTGCTAAAGAAGTAGAACAAAGGAGGGGGGTGGAT

ATAGTCGGAAATATGCCAGCAAGGCCAAGAATTTAGCTGACGACATGGTTAGGAA

TACAGCTAGAGACCTTTTATACTATGCCGTCACCCAGGATGCCATGTTGATATTT

GAAAATTTAAGTAGAGGCTTCGGTAGACAAGGTAAGCGCACCTTCATGGCAGAGA

GACAATATACTAGAATGGAAGATTGGTTGACTGCCAAATTGGCATACGAAGGTCT

ACCTAGTAAGACGTACTTATCTAAAACACTAGCGCAGTATACTTCCAAGACATGC

AGTAATTGTGGTTTCACAATCACTTCTGCCGATTACGATCGCGTCTTGGAAAAAC

TAAAAAAAACAGCGACAGGTTGGATGACTACTATTAATGGGAAAGAATTGAAGGT

CGAAGGACAAATAACTTACTATAATAGATATAAACGGCAAAACGTTGTAAAAGAC

CTGTCAGTCGAACTCGATCGACTTAGTGAAGAATCTGTTAATAATGATATTAGTT

CGTGGACAAAAGGTAGATCCGGTGAAGCTTTGAGCCTCCTGAAAAAACGTTTTAG

CCATAGGCCTGTCCAAGAAAAGTTTGTATGTTTAAACTGTGGTTTTGAGACCCAT

GCAGACGAGCAGGCCGCTCTTAATATTGCTAGATCATGGTTATTTTTAAGATCTC

AGGAATACAAGAAGTACCAGACTAACAAGACAACAGGCAACACAGATAAGCGAGC

ATTCGTTGAGACTTGGCAATCTTTTTATAGAAAGAAATTGAAGGAAGTCTGGAAA

CCA

SEQ
ATGGGAAAAATGTATTATCTAGGCCTGGACATAGGGACCAATTCAGTAGGCTACG

ID
CTGTCACTGACCCCTCCTACCATTTGCTGAAGTTCAAGGGGGAACCCATGTGGGG

NO:
AGCACACGTGTTTGCGGCCGGCAACCAGAGCGCAGAGCGGAGAAGCTTCCGCACC

147
TCCAGGAGAAGGCTGGATCGCAGGCAGCAGCGTGTGAAGCTGGTCCAAGAGATAT

TTGCCCCAGTGATTTCCCCCATCGATCCGCGCTTCTTTATTAGGCTCCACGAGTC

CGCTCTCTGGCGCGACGACGTGGCCGAAACTGATAAACATATTTTCTTTAATGAC

CCAACATACACTGACAAGGAGTACTATTCAGATTACCCAACAATTCACCATTTGA

TCGTGGACCTTATGGAAAGTTCGGAGAAGCATGATCCTCGACTTGTCTATTTGGC

CGTGGCGTGGCTCGTGGCACATAGGGGCCACTTCTTGAACGAGGTGGACAAGGAT

AACATCGGGGATGTGTTATCTTTCGACGCTTTCTATCCTGAATTCCTTGCTTTTC

TGTCTGACAATGGCGTCAGCCCGTGGGTCTGCGAATCCAAGGCCCTCCAGGCTAC

GCTATTGTCAAGAAATAGCGTGAACGACAAGTACAAGGCTCTTAAGTCTTTGATT

TTTGGAAGCCAGAAGCCCGAGGACAACTTTGATGCAAATATCTCGGAGGACGGGC

TGATTCAGCTCCTCGCTGGGAAAAAGGTCAAGGTCAATAAGCTGTTTCCACAGGA

GTCAAATGACGCGAGCTTCACCCTTAACGACAAAGAGGATGCCATTGAAGAGATC

CTGGGGACACTCACCCCAGACGAGTGCGAGTGGATAGCCCATATTAGGCGCCTCT

TTGATTGGGCCATAATGAAACATGCGCTTAAGGACGGGCGCACGATATCCGAAAG

CAAGGTCAAATTGTACGAGCAGCACCACCATGATCTGACCCAGCTAAAATATTTT

GTAAAAACATATCTGGCCAAGGAGTACGATGATATCTTCCGCAACGTGGATAGTG

AGACCACCAAAAACTACGTCGCGTACTCATACCACGTGAAAGAAGTTAAGGGCAC

GCTGCCTAAGAACAAGGCAACACAAGAGGAGTTCTGCAAGTACGTTCTCGGGAAA

GTTAAAAATATAGAGTGCAGCGAGGCCGACAAAGTGGATTTTGACGAGATGATTC

AACGCCTGACCGACAATTCGTTTATGCCTAAACAGGTGAGTGGAGAGAATCGCGT

GATTCCATATCAGCTCTATTACTATGAACTCAAGACTATTCTGAATAAGGCCGCT

AGCTATTTACCCTTCCTTACGCAGTGCGGGAAGGATGCCATTTCTAACCAGGATA

AACTCTTGAGTATAATGACATTTCGAATTCCCTATTTCGTGGGTCCGCTTCGTAA

GGATAACAGTGAGCACGCTTGGCTGGAGCGGAAGGCTGGCAAAATTTATCCATGG

AATTTCAACGACAAGGTGGATCTGGACAAATCCGAAGAAGCCTTTATCCGCAGGA

TGACCAATACTTGCACATACTATCCTGGGGAGGATGTCCTTCCACTGGACTCTCT

GATCTACGAAAAGTTCATGATTTTGAATGAAATTAACAACATAAGGATCGATGGG

TATCCTATTTCCGTCGACGTGAAGCAGCAGGTGTTCGGGCTCTTTGAGAAGAAGC

GACGGGTGACCGTGAAGGATATTCAGAATCTTCTCTTATCGCTGGGAGCCCTGGA

TAAACACGGAAAACTGACCGGGATAGATACTACGATTCATTCTAATTACAACACG

TATCACCATTTTAAGTCACTGATGGAGAGGGGCGTCCTAACAAGAGATGACGTGG

AGAGAATAGTGGAACGAATGACATATTCTGATGACACCAAGAGAGTGCGGCTTTG

GCTGAATAACAACTACGGCACTCTGACGGCGGATGATGTAAAGCATATTTCCCGA

CTCCGTAAGCATGACTTCGGGCGGCTGTCTAAGATGTTTCTAACAGGCCTCAAGG

GTGTGCATAAGGAAACTGGGGAGCGCGCTAGCATCCTGGATTTTATGTGGAACAC

CAATGATAACCTGATGCAGCTCCTGTCAGAATGCTACACATTTTCGGACGAAATC

ACCAAGCTGCAGGAGGCTTACTATGCCAAGGCCCAACTAAGCTTGAATGATTTCC

TGGATTCTATGTACATCAGCAACGCCGTAAAACGACCAATTTATAGGACACTGGC

AGTGGTTAACGACATTAGGAAAGCATGCGGAACAGCTCCCAAGCGAATCTTTATC

GAGATGGCCCGCGACGGCGAGAGTAAGAAGAAAAGGTCAGTGACTAGGCGGGAGC

AGATCAAGAACCTTTACCGCTCTATCCGAAAAGACTTCCAGCAAGAGGTTGATTT

CCTTGAGAAGATCTTAGAGAACAAGTCAGATGGACAGCTCCAATCCGATGCTCTG

TATCTGTACTTCGCTCAGCTGGGACGAGATATGTACACTGGCGACCCCATTAAAC

TAGAACATATCAAGGACCAATCGTTTTATAATATCGACCACATCTACCCTCAGTC

CATGGTGAAAGACGATAGTCTGGACAATAAGGTGCTCGTCCAAAGTGAGATTAAC

GGAGAAAAGTCGAGCAGATATCCTTTGGACGCTGCGATCCGCAACAAGATGAAGC

CCCTGTGGGATGCTTACTACAATCATGGACTGATCAGCCTGAAGAAGTATCAGAG

ACTGACCCGGAGTACCCCTTTCACAGACGATGAGAAGTGGGATTTTATCAATAGA

CAACTGGTGGAAACCAGGCAGTCCACGAAAGCTCTGGCCATTCTTCTGAAGAGAA

AGTTTCCAGACACAGAGATCGTCTATTCAAAGGCCGGCCTCAGTTCCGACTTTAG

ACATGAGTTCGGACTCGTTAAATCACGAAATATAAACGATCTCCACCATGCAAAG

GACGCATTCCTCGCGATTGTGACTGGAAATGTCTATCACGAAAGATTTAATAGGC

GGTGGTTCATGGTTAACCAGCCATACTCAGTGAAGACCAAGACCCTTTTCACTCA

CTCTATTAAAAATGGCAACTTCGTGGCTTGGAATGGTGAGGAGGATCTTGGAAGA

ATTGTGAAGATGTTAAAACAGAATAAGAATACCATCCACTTTACTAGATTCAGCT

TTGACCGAAAAGAGGGGCTATTCGATATTCAACCGTTAAAGGCTTCAACAGGTCT

CGTTCCACGAAAGGCCGGACTGGACGTAGTGAAATACGGCGGCTATGATAAGAGC

ACCGCAGCTTACTACCTCCTTGTGCGATTTACGCTCGAGGATAAGAAGACCCAAC

ACAAGCTGATGATGATTCCCGTGGAGGGACTGTACAAAGCTCGAATTGACCATGA

TAAAGAGTTTCTCACAGATTACGCACAAACCACCATCTCTGAGATTCTCCAGAAA

GACAAACAAAAAGTTATAAACATAATGTTTCCAATGGGTACAAGGCATATTAAAC

TGAACAGCATGATCTCCATTGATGGCTTTTATTTGTCCATTGGAGGAAAGTCTAG

TAAAGGCAAGTCTGTCCTCTGCCATGCCATGGTACCCCTAATCGTCCCACACAAG

ATTGAATGCTACATCAAGGCTATGGAGAGTTTTGCTCGGAAATTTAAAGAGAATA

ATAAGCTGCGTATTGTGGAAAAATTCGACAAGATAACCGTTGAAGACAATCTGAA

TCTGTACGAGCTCTTTCTGCAGAAGCTGCAGCATAACCCCTATAATAAGTTCTTC

TCCACACAGTTCGATGTACTGACCAACGGGCGATCAACTTTCACAAAGCTAAGTC

CTGAGGAACAGGTGCAAACACTCCTAAACATTCTTTCCATTTTTAAGACCTGCAG

ATCTTCAGGATGCGACTTGAAGAGCATTAACGGGAGCGCACAGGCAGCTAGGATC

ATGATCTCAGCTGACCTGACAGGGCTGAGTAAAAAATACTCCGACATTCGGCTTG

TAGAGCAAAGCGCCAGTGGGTTGTTCGTTAGTAAGTCGCAGAACCTGCTGGAATA

CCTGTAA

SEQ
ATGTCTTCTTTGACGAAGTTTACAAACAAATACTCTAAGCAGCTTACAATTAAGA

ID
ACGAACTGATTCCCGTAGGAAAGACTCTGGAAAACATCAAAGAGAATGGGCTGAT

NO:
AGACGGCGACGAACAACTGAATGAGAACTATCAGAAGGCCAAAATTATCGTGGAT

148
GACTTCCTGAGGGATTTTATTAACAAGGCCCTGAATAATACCCAGATCGGCAATT

GGCGGGAACTGGCCGACGCTCTGAACAAAGAAGATGAGGACAATATCGAAAAATT

ACAAGACAAAATCAGGGGCATTATTGTCAGTAAGTTCGAGACATTCGATCTGTTC

TCTTCGTACTCCATTAAGAAGGACGAGAAAATCATCGATGATGACAATGACGTTG

AGGAAGAAGAACTGGACTTGGGTAAAAAGACCTCATCCTTCAAGTATATTTTTAA

AAAAAATCTGTTTAAATTAGTGCTCCCCAGTTATTTAAAGACAACTAACCAGGAC

AAGCTTAAGATTATCTCCTCTTTTGACAACTTTAGCACCTATTTTAGAGGCTTCT

TTGAAAATCGCAAGAATATTTTCACTAAGAAGCCCATAAGCACCTCTATTGCCTA

CAGAATCGTACATGATAACTTCCCAAAATTTTTGGATAACATTAGATGTTTTAAT

GTATGGCAGACCGAATGTCCTCAGTTAATTGTGAAGGCGGATAACTACCTCAAAT

CCAAGAATGTGATCGCCAAAGATAAGTCTCTTGCTAACTACTTTACGGTCGGAGC

CTACGATTACTTCTTATCTCAAAACGGTATTGACTTTTACAATAACATTATCGGG

GGATTGCCTGCCTTCGCCGGCCATGAGAAAATTCAGGGCTTAAACGAGTTCATAA

ATCAGGAATGTCAAAAGGACTCAGAGCTGAAATCAAAGCTTAAGAATCGACACGC

ATTTAAAATGGCGGTCTTGTTCAAACAGATCCTCAGCGATAGAGAGAAAAGCTTC

GTTATTGATGAATTCGAGAGCGACGCACAGGTGATTGATGCCGTGAAGAACTTCT

ATGCGGAACAGTGTAAAGACAATAATGTTATTTTCAACCTATTAAACTTGATTAA

GAATATCGCGTTTTTAAGTGACGATGAACTCGACGGTATCTTTATAGAAGGCAAG

TACCTGTCCTCTGTCAGCCAAAAACTCTACTCAGATTGGTCCAAGCTAAGAAATG

ACATCGAGGACAGTGCTAACAGCAAACAGGGCAATAAAGAGCTGGCAAAGAAAAT

CAAGACTAATAAAGGGGATGTGGAGAAGGCGATATCTAAATATGAGTTCTCCCTC

TCCGAACTGAACTCCATCGTCCACGATAATACCAAGTTTAGTGATCTGTTGTCGT

GTACACTGCACAAAGTGGCCAGTGAAAAACTCGTCAAGGTGAACGAAGGCGATTG

GCCCAAACACCTGAAAAATAATGAGGAGAAACAGAAGATCAAAGAACCTTTGGAT

GCGTTGCTCGAAATATATAACACACTGTTGATCTTCAACTGTAAAAGCTTCAACA

AGAACGGGAACTTTTATGTAGACTACGATCGATGTATAAATGAACTGAGCAGCGT

CGTTTACCTGTACAACAAGACTCGCAATTATTGTACGAAAAAACCATATAACACC

GATAAGTTCAAGCTTAATTTCAACAGTCCCCAGCTGGGAGAAGGGTTCAGCAAAT

CAAAAGAAAACGATTGCCTGACATTACTCTTTAAAAAGGATGATAATTATTATGT

TGGGATTATTAGGAAAGGCGCTAAGATCAACTTTGACGACACACAGGCCATAGCT

GACAACACTGATAACTGCATCTTTAAAATGAATTACTTTCTGTTGAAGGACGCCA

AAAAATTCATTCCAAAATGCTCTATTCAGCTCAAGGAGGTTAAGGCCCATTTCAA

GAAGTCTGAAGATGACTACATCCTCTCTGACAAGGAAAAATTCGCTAGTCCTCTG

GTTATCAAAAAAAGTACCTTCTTGCTGGCTACAGCTCACGTGAAAGGCAAGAAAG

GGAACATTAAGAAGTTCCAAAAGGAATACAGCAAAGAGAATCCAACCGAGTACAG

AAATTCTCTGAACGAATGGATCGCATTCTGTAAAGAATTTCTAAAGACGTACAAG

GCCGCTACCATTTTCGATATTACCACCTTGAAAAAAGCCGAGGAGTACGCCGACA

TCGTCGAATTCTATAAAGACGTGGATAACCTGTGTTACAAATTGGAATTCTGCCC

AATTAAGACCTCTTTCATTGAAAACCTCATCGACAATGGGGACCTCTACTTATTT

AGAATTAACAATAAGGATTTTTCTTCGAAATCTACCGGAACTAAAAATCTGCACA

CACTGTATCTGCAAGCAATCTTCGATGAACGTAATCTCAACAACCCTACAATAAT

GCTGAACGGCGGTGCTGAACTGTTCTACCGTAAAGAGAGTATTGAACAGAAGAAT

CGAATCACACACAAAGCGGGCAGTATTCTCGTCAATAAGGTGTGCAAAGACGGGA

CCAGCCTGGACGATAAGATCAGGAATGAAATATATCAGTATGAGAACAAGTTTAT

CGACACCTTGTCGGATGAGGCAAAGAAGGTGCTACCTAACGTTATCAAGAAGGAA

GCTACCCATGACATAACCAAGGATAAGCGGTTCACTTCTGACAAGTTCTTCTTCC

ACTGTCCTCTGACCATTAACTACAAGGAAGGAGACACTAAACAATTCAATAATGA

AGTACTTAGCTTTTTGCGGGGTAATCCCGATATTAACATAATTGGTATCGACCGG

GGAGAACGGAACCTGATATACGTGACAGTAATTAATCAGAAAGGAGAAATCCTGG

ATTCCGTATCCTTCAATACCGTGACTAATAAATCTAGTAAAATCGAGCAGACGGT

CGACTACGAGGAAAAGTTAGCAGTCAGAGAGAAGGAGAGAATCGAGGCCAAACGT

TCCTGGGATAGTATCAGCAAGATTGCTACTCTGAAAGAAGGATATCTGTCCGCTA

TCGTCCATGAGATCTGTTTGTTGATGATCAAGCACAATGCTATAGTGGTTCTGGA

GAACCTGAACGCAGGCTTCAAGCGAATTAGAGGGGGCCTGTCGGAAAAAAGCGTT

TACCAGAAGTTTGAAAAGATGCTAATCAATAAGTTAAATTACTTTGTAAGTAAAA

AAGAAAGCGATTGGAATAAGCCATCAGGACTTTTAAACGGGCTGCAACTGAGCGA

CCAGTTTGAGTCATTCGAAAAACTGGGTATTCAGAGTGGTTTCATATTCTACGTA

CCTGCCGCTTACACTTCAAAGATCGATCCTACAACTGGTTTTGCGAATGTCCTGA

ATCTGTCTAAGGTGAGGAATGTGGACGCAATCAAGTCTTTCTTCAGCAACTTCAA

CGAGATATCTTACAGCAAGAAAGAGGCTCTGTTTAAATTCAGTTTTGATCTGGAT

AGCCTGAGCAAGAAAGGATTCTCTTCTTTCGTAAAGTTTTCTAAGTCCAAATGGA

ACGTCTACACGTTCGGAGAGAGAATCATTAAACCAAAGAACAAGCAGGGGTATCG

GGAAGACAAAAGGATCAATCTGACTTTCGAAATGAAGAAACTATTGAATGAGTAC

AAAGTCTCATTCGATTTGGAGAACAATCTGATCCCCAATCTGACCAGCGCTAACC

TCAAAGACACATTCTGGAAGGAGCTGTTTTTCATCTTTAAGACCACCCTGCAGCT

ACGGAATAGTGTCACAAATGGGAAAGAGGATGTACTGATCTCACCTGTGAAAAAC

GCCAAGGGGGAGTTCTTTGTGTCCGGCACCCATAACAAAACCCTGCCTCAGGACT

GTGACGCGAACGGGGCCTACCACATCGCGCTAAAGGGGTTAATGATTCTCGAACG

TAATAATCTGGTGCGCGAAGAAAAAGACACAAAGAAAATTATGGCCATCAGCAAC

GTTGACTGGTTTGAGTACGTGCAGAAGCGTCGAGGAGTTTTGTAA

SEQ
ATGAACAACTATGACGAGTTCACTAAACTTTACCCCATTCAGAAAACCATCAGAT

ID
TTGAACTGAAGCCTCAGGGTCGTACCATGGAACACTTGGAAACTTTCAACTTTTT

NO:
CGAGGAGGACAGGGATAGAGCTGAGAAATACAAGATCTTGAAAGAGGCCATCGAC

149
GAGTATCACAAAAAATTCATCGATGAGCATCTCACCAACATGTCGCTGGATTGGA

ACAGTCTCAAGCAGATTTCCGAGAAGTACTATAAATCTCGGGAGGAGAAAGATAA

AAAGGTGTTTTTGAGCGAGCAAAAGCGAATGCGACAGGAGATAGTCTCTGAATTT

AAGAAAGATGATCGGTTTAAAGACCTATTTTCCAAAAAGCTTTTTTCAGAGCTGC

TGAAGGAAGAGATCTATAAAAAAGGCAATCACCAAGAAATTGATGCCCTGAAATC

ATTCGACAAATTCAGTGGGTATTTCATAGGACTGCATGAGAACCGGAAGAATATG

TATAGTGATGGAGACGAGATCACAGCCATAAGCAATCGAATCGTTAACGAGAATT

TCCCGAAGTTCCTGGATAACCTGCAGAAGTATCAAGAGGCTAGGAAAAAGTACCC

TGAGTGGATCATCAAGGCTGAATCAGCTCTGGTGGCTCACAATATCAAGATGGAT

GAAGTCTTTAGTCTTGAGTACTTTAATAAAGTCCTTAACCAGGAGGGCATCCAGC

GCTATAACCTGGCTCTCGGTGGCTACGTCACAAAAAGCGGAGAAAAGATGATGGG

TCTCAACGATGCACTGAATTTGGCTCATCAGTCGGAGAAGTCATCTAAGGGACGC

ATACACATGACACCACTGTTTAAACAAATCCTGAGCGAAAAGGAATCATTTTCCT

ACATTCCCGACGTATTCACCGAGGACTCACAACTGCTGCCTAGTATAGGGGGGTT

TTTCGCTCAGATAGAGAACGACAAAGATGGCAACATTTTTGACAGAGCCTTGGAG

TTGATTTCATCTTACGCCGAGTACGATACGGAGCGCATTTATATTCGCCAGGCGG

ATATCAACAGGGTTTCCAATGTGATCTTTGGCGAGTGGGGAACGCTGGGCGGGCT

GATGCGGGAATACAAAGCCGACTCGATCAATGACATCAACCTGGAGAGAACATGC

AAGAAGGTCGATAAATGGTTGGATAGCAAAGAGTTCGCCCTGAGTGACGTCTTGG

AAGCTATCAAAAGAACCGGAAATAATGACGCGTTCAACGAGTATATCTCTAAAAT

GAGGACCGCGAGAGAAAAAATTGATGCAGCAAGGAAGGAGATGAAGTTTATATCT

GAGAAGATCTCAGGCGATGAAGAGTCCATCCATATTATTAAAACTCTTCTGGACT

CAGTGCAGCAATTCCTGCACTTTTTTAACCTCTTCAAGGCCAGGCAGGATATACC

GTTAGACGGGGCTTTTTATGCCGAGTTTGATGAAGTTCATTCGAAACTTTTTGCT

ATAGTGCCTCTCTATAATAAAGTTCGCAATTACCTGACAAAGAATAACTTAAACA

CAAAGAAAATCAAGCTCAACTTCAAAAACCCAACACTGGCAAACGGATGGGATCA

GAACAAGGTATATGATTACGCCTCATTGATTTTCCTCCGGGACGGGAATTACTAT

CTGGGGATCATCAACCCTAAGCGCAAAAAGAACATTAAGTTCGAACAGGGATCTG

GCAATGGTCCCTTCTATAGGAAAATGGTATACAAACAGATTCCTGGCCCCAACAA

GAATCTCCCACGCGTCTTTCTGACGTCCACTAAGGGAAAGAAGGAGTACAAGCCG

TCTAAAGAAATTATCGAGGGCTATGAGGCAGACAAGCATATTAGGGGTGACAAGT

TTGACCTAGACTTTTGTCATAAGCTTATCGACTTTTTCAAGGAGTCCATAGAGAA

GCACAAAGATTGGTCAAAGTTTAATTTCTATTTTTCTCCAACAGAGTCCTACGGG

GATATCTCTGAGTTCTATCTGGATGTTGAAAAGCAGGGGTACAGAATGCACTTCG

AAAATATCTCAGCAGAAACTATCGATGAGTACGTAGAGAAAGGAGATCTGTTTCT

TTTCCAAATCTACAATAAGGATTTTGTGAAGGCCGCCACTGGGAAGAAGGACATG

CACACTATTTACTGGAACGCTGCATTTTCCCCTGAAAATCTGCAGGACGTAGTAG

TGAAATTAAATGGTGAGGCAGAACTGTTTTACCGCGATAAATCAGACATCAAGGA

AATAGTGCACCGGGAAGGCGAGATTCTTGTTAACCGAACATATAATGGCAGGACA

CCTGTCCCTGATAAAATTCATAAGAAACTGACCGATTACCACAACGGTCGAACCA

AGGATCTGGGCGAGGCCAAGGAATACCTCGATAAGGTGAGGTACTTCAAAGCCCA

TTATGACATCACCAAGGACCGAAGATACCTTAACGACAAAATCTACTTCCATGTC

CCACTCACCTTGAACTTCAAAGCTAACGGTAAGAAGAACCTCAATAAAATGGTGA

TTGAAAAATTTCTGTCCGATGAGAAGGCCCATATCATCGGCATTGATCGCGGCGA

GAGAAATCTCCTTTACTATTCTATCATTGATCGGTCGGGAAAGATTATCGACCAA

CAATCACTGAATGTCATCGACGGATTCGACTATAGAGAGAAGCTGAACCAACGGG

AAATCGAGATGAAGGACGCGCGCCAGTCCTGGAACGCTATCGGCAAAATTAAAGA

TTTGAAAGAAGGTTACCTCTCCAAAGCAGTGCACGAAATTACCAAAATGGCAATC

CAGTACAATGCTATTGTGGTAATGGAGGAGTTAAATTACGGATTTAAGCGCGGGA

GGTTCAAGGTTGAAAAGCAAATTTACCAAAAATTTGAGAACATGTTGATTGATAA

GATGAACTACCTGGTGTTCAAGGACGCACCTGACGAGTCGCCAGGCGGCGTGTTA

AATGCATATCAGCTGACAAATCCACTGGAGAGCTTTGCCAAGCTAGGAAAGCAGA

CTGGCATTCTCTTTTACGTCCCTGCAGCGTATACATCCAAAATTGACCCCACCAC

TGGCTTCGTCAATCTGTTTAACACCTCCTCCAAAACCAACGCACAAGAACGGAAA

GAATTTTTGCAAAAGTTTGAGTCCATTAGCTACTCTGCCAAAGACGGCGGGATCT

TTGCTTTCGCATTCGACTACAGGAAATTCGGGACGAGTAAGACAGACCACAAGAA

CGTCTGGACCGCGTACACTAATGGGGAACGCATGCGCTACATCAAAGAGAAAAAG

AGGAATGAACTTTTTGACCCTTCAAAGGAAATCAAGGAAGCTCTCACCTCAAGCG

GTATCAAATACGATGGCGGGCAGAATATTTTGCCAGATATCCTCAGATCGAACAA

TAATGGACTTATCTATACTATGTACTCCTCCTTCATTGCAGCAATTCAAATGAGA

GTGTACGATGGAAAGGAGGATTACATTATATCGCCAATTAAGAACTCCAAAGGCG

AATTCTTCCGCACGGATCCTAAGCGAAGAGAACTCCCAATCGACGCTGATGCGAA

CGGCGCCTATAATATAGCCCTGCGGGGTGAATTAACAATGCGCGCTATTGCCGAG

AAGTTCGACCCCGATTCAGAAAAAATGGCTAAGCTTGAGCTGAAACACAAAGATT

GGTTCGAATTCATGCAGACAAGAGGCGACTAA

SEQ
ATGACTAAGACCTTCGATTCCGAGTTCTTCAACCTTTATTCCCTGCAGAAAACT

ID
GTAAGGTTTGAGCTGAAGCCGGTGGGCGAGACAGCCAGCTTCGTAGAGGATTTCA

NO:
AGAATGAGGGTCTCAAACGGGTAGTTAGTGAGGATGAGAGGAGAGCAGTGGACTA

150
TCAGAAGGTGAAAGAGATCATCGATGACTATCACCGGGATTTCATAGAGGAGTCG

TTGAATTACTTCCCTGAGCAAGTATCCAAAGACGCGCTGGAACAGGCCTTTCATC

TTTACCAGAAACTGAAGGCAGCGAAGGTTGAGGAGCGGGAAAAGGCCTTGAAAGA

GTGGGAAGCCCTGCAGAAAAAGCTCAGAGAAAAGGTTGTCAAATGCTTCAGCGAC

AGCAACAAAGCCAGGTTCAGTAGGATCGATAAGAAAGAACTGATCAAAGAAGACT

TGATCAATTGGCTGGTTGCACAGAACCGGGAAGATGATATTCCCACCGTAGAGAC

CTTCAACAACTTCACAACTTACTTCACCGGCTTCCATGAGAATCGTAAAAACATC

TACAGTAAAGATGATCATGCAACCGCCATCTCCTTCCGGTTGATCCACGAGAATC

TCCCCAAGTTCTTTGACAACGTGATAAGTTTCAATAAGTTGAAAGAGGGATTTCC

CGAACTCAAGTTCGATAAAGTGAAGGAGGATCTGGAAGTGGATTATGACCTTAAG

CACGCTTTCGAGATAGAGTACTTCGTGAACTTTGTGACTCAGGCCGGCATCGATC

AGTATAACTACCTCCTCGGGGGTAAGACGCTCGAGGACGGTACTAAGAAGCAAGG

AATGAATGAGCAAATTAATCTATTTAAACAGCAGCAGACCAGGGATAAGGCTAGA

CAGATCCCCAAGCTTATTCCTCTTTTTAAACAGATCCTAAGTGAAAGGACAGAAA

GTCAAAGCTTCATACCTAAGCAATTTGAAAGTGATCAGGAGCTGTTTGACTCCCT

GCAAAAGCTGCACAACAATTGCCAGGACAAGTTTACCGTGCTGCAGCAGGCTATC

CTCGGACTGGCTGAGGCGGATCTTAAGAAGGTATTCATTAAGACTAGCGACCTCA

ATGCCCTTAGTAACACCATCTTTGGAAATTACTCCGTTTTCAGCGATGCCCTCAA

TCTATACAAAGAGAGCTTGAAGACTAAAAAAGCTCAGGAAGCTTTTGAAAAATTA

CCGGCACATTCTATACACGACCTTATACAATACTTAGAGCAGTTCAACAGCAGCC

TCGACGCTGAGAAACAGCAATCCACAGACACCGTCCTGAATTACTTCATCAAAAC

CGATGAACTGTACTCCCGATTTATCAAGAGCACTTCAGAAGCCTTCACGCAAGTT

CAGCCTCTGTTCGAGCTGGAGGCACTGTCCAGCAAGAGACGACCGCCAGAGTCTG

AAGACGAGGGAGCCAAGGGTCAAGAGGGGTTTGAACAGATAAAGCGAATTAAGGC

TTACTTGGATACTCTCATGGAGGCGGTGCATTTCGCTAAGCCTTTGTACCTGGTT

AAAGGCCGAAAAATGATTGAGGGGCTAGATAAGGATCAGTCTTTTTACGAGGCTT

TTGAAATGGCCTACCAGGAATTGGAATCCTTGATCATTCCAATCTATAATAAAGC

CCGGAGTTATCTGAGCAGGAAGCCCTTCAAAGCCGACAAGTTCAAAATAAATTTT

GACAATAATACGCTACTGTCTGGTTGGGACGCTAACAAGGAAACAGCCAATGCTT

CCATCCTGTTTAAGAAAGACGGCCTGTACTACCTGGGAATTATGCCAAAAGGCAA

AACTTTTTTGTTCGATTACTTTGTGTCATCAGAGGATAGCGAGAAGTTAAAGCAA

AGACGGCAGAAGACCGCCGAAGAAGCCCTCGCACAAGACGGAGAATCATATTTCG

AGAAAATTCGATATAAGCTCCTGCCTGGCGCATCAAAGATGTTGCCAAAAGTCTT

CTTTTCCAACAAAAACATCGGCTTTTATAACCCCAGCGATGATATCCTTCGCATC

CGGAACACCGCCTCACATACCAAAAATGGAACTCCACAGAAGGGCCACTCGAAGG

TTGAATTCAACCTTAACGATTGTCACAAAATGATTGATTTTTTTAAGAGCTCCAT

TCAGAAACACCCCGAATGGGGGTCCTTTGGCTTCACCTTTTCTGATACTTCAGAC

TTCGAGGACATGTCCGCCTTCTACAGGGAGGTGGAGAACCAGGGCTATGTCATCT

CCTTCGACAAAATAAAAGAGACATACATTCAGAGCCAGGTCGAGCAGGGAAATCT

GTACCTGTTTCAGATCTATAACAAGGATTTCAGTCCCTATAGCAAGGGCAAGCCC

AATTTACATACCCTGTACTGGAAGGCCCTGTTCGAAGAGGCAAACCTTAACAATG

TAGTTGCTAAGCTGAATGGGGAAGCAGAGATCTTCTTCCGAAGGCACAGCATCAA

GGCAAGCGACAAAGTTGTACATCCTGCTAACCAGGCCATCGATAACAAGAACCCG

CATACAGAAAAGACACAGTCAACCTTTGAATACGACCTCGTGAAGGACAAGAGGT

ACACACAAGATAAATTCTTCTTCCACGTGCCCATCAGCTTGAATTTTAAAGCGCA

GGGAGTGAGCAAATTTAACGACAAGGTCAACGGCTTCCTGAAGGGAAACCCCGAC

GTGAATATCATCGGAATTGATCGCGGTGAAAGACATCTCCTCTACTTTACTGTGG

TGAACCAGAAGGGTGAGATCCTAGTACAGGAGAGCCTGAACACCCTTATGAGTGA

TAAGGGCCATGTGAATGATTACCAGCAGAAGCTGGACAAGAAGGAACAGGAAAGG

GACGCAGCGCGGAAGTCCTGGACCACTGTTGAGAATATCAAAGAACTGAAGGAGG

GATATCTTAGCCATGTGGTACACAAACTTGCACATCTGATTATCAAGTATAATGC

CATAGTCTGCCTGGAAGACTTGAACTTCGGTTTCAAGCGAGGAAGGTTTAAAGTG

GAGAAGCAGGTGTACCAGAAGTTTGAGAAAGCCCTTATTGATAAGCTAAACTACC

TTGTCTTTAAGGAAAAAGAACTCGGCGAAGTTGGCCACTATTTAACCGCCTACCA

ACTAACCGCCCCTTTCGAGTCTTTTAAGAAACTGGGAAAGCAGAGCGGAATACTC

TTCTATGTGCCTGCAGACTACACCTCTAAGATCGACCCCACTACCGGCTTTGTAA

ACTTTCTAGATCTCCGCTATCAGTCAGTAGAAAAAGCCAAACAGCTCTTGTCAGA

TTTTAACGCCATCCGATTTAATTCCGTCCAAAATTACTTCGAGTTCGAAATCGAC

TATAAAAAACTTACCCCCAAGAGAAAGGTTGGGACGCAGTCTAAGTGGGTAATCT

GCACTTACGGTGACGTGAGATACCAGAACCGCCGAAACCAGAAAGGTCATTGGGA

AACCGAGGAAGTGAATGTGACTGAGAAGCTCAAGGCCCTCTTCGCTAGCGACAGT

AAAACAACAACAGTTATCGATTACGCCAATGACGATAATCTTATAGACGTGATCT

TGGAACAAGACAAAGCCTCTTTTTTTAAGGAATTGTTGTGGTTGCTGAAACTTAC

AATGACCCTTAGGCACAGCAAGATCAAATCAGAGGATGACTTCATCCTCAGCCCG

GTGAAGAATGAACAGGGAGAGTTCTACGATTCACGGAAGGCTGGAGAGGTGTGGC

CCAAGGATGCCGACGCGAACGGGGCCTACCACATAGCTCTAAAAGGTCTGTGGAA

CCTGCAACAAATCAATCAATGGGAGAAAGGTAAGACACTGAACCTGGCCATCAAA

AATCAAGATTGGTTCTCATTCATCCAGGAAAAGCCTTATCAAGAGTGA

SEQ
ATGCATACGGGAGGCCTTTTATCAATGGACGCAAAAGAGTTCACCGGGCAGTATC

ID
CATTATCTAAGACACTCCGCTTCGAGCTGAGGCCCATTGGCAGGACCTGGGACAA

NO:
CCTGGAGGCGTCGGGCTACCTGGCTGAGGACAGACATCGCGCAGAATGCTATCCG

151
AGAGCTAAGGAGCTTTTGGACGACAATCATCGCGCGTTCCTTAACCGGGTGCTCC

CACAGATCGATATGGACTGGCACCCGATCGCTGAGGCTTTTTGCAAGGTCCATAA

GAACCCTGGGAACAAAGAGCTCGCCCAGGACTACAACTTGCAGCTGAGCAAGCGA

CGGAAAGAGATTTCTGCCTACCTTCAAGACGCCGATGGCTACAAAGGGCTCTTCG

CAAAGCCCGCATTGGATGAGGCCATGAAAATCGCCAAGGAGAACGGGAATGAAAG

TGACATCGAAGTTCTCGAAGCGTTTAACGGATTTAGCGTGTACTTTACCGGCTAT

CATGAGTCAAGGGAGAATATTTATAGCGATGAGGACATGGTCTCTGTGGCCTACC

GGATTACCGAGGATAATTTCCCGAGGTTTGTTTCAAATGCACTAATATTCGACAA

GTTAAATGAGAGCCACCCAGACATCATCTCGGAGGTCAGCGGCAACCTCGGAGTT

GACGATATTGGCAAATACTTCGACGTGAGCAACTATAACAACTTCCTCTCACAGG

CTGGCATCGACGACTATAATCATATTATAGGCGGCCACACTACTGAGGATGGTCT

CATTCAGGCATTCAATGTAGTCTTGAATCTTAGGCACCAGAAGGACCCTGGGTTT

GAAAAGATACAGTTCAAGCAGCTGTATAAGCAGATATTATCCGTGCGAACATCTA

AAAGTTACATCCCCAAACAGTTTGATAACTCAAAGGAGATGGTGGATTGCATATG

CGATTATGTGTCAAAAATTGAAAAGAGCGAGACTGTGGAGCGGGCTCTGAAGCTC

GTCAGGAACATTAGCTCCTTTGACCTTAGAGGAATTTTCGTCAATAAAAAGAATC

TGAGGATCCTGAGCAATAAGCTAATAGGAGATTGGGACGCCATAGAGACAGCATT

GATGCATTCCAGCTCAAGCGAGAATGATAAGAAGTCTGTCTACGATAGCGCTGAA

GCCTTCACGCTGGACGATATCTTCTCTTCCGTGAAAAAATTTAGTGATGCGTCCG

CAGAAGATATCGGGAATCGAGCCGAAGATATCTGCAGGGTAATTTCAGAGACCGC

CCCTTTCATCAATGACCTGCGCGCCGTGGACCTGGATAGCCTGAATGACGATGGT

TACGAAGCTGCAGTTTCTAAGATCAGGGAGTCTCTGGAGCCATATATGGACTTGT

TTCACGAACTTGAGATCTTTAGCGTGGGCGACGAGTTCCCGAAATGCGCAGCTTT

CTATAGCGAGTTAGAGGAGGTCAGCGAGCAATTAATCGAGATCATACCCCTGTTT

AATAAGGCACGGAGCTTTTGTACTCGCAAGCGCTACAGCACCGACAAGATTAAAG

TTAATCTGAAATTTCCAACTCTCGCAGACGGGTGGGACCTAAACAAGGAACGCGA

TAATAAAGCCGCCATCCTTAGAAAGGACGGAAAGTACTATCTTGCCATCCTAGAT

ATGAAAAAAGATCTGAGTTCCATTCGTACTAGCGATGAAGACGAATCTTCTTTCG

AAAAAATGGAGTATAAGCTGCTCCCCTCGCCAGTCAAGATGCTACCCAAGATCTT

TGTGAAGAGCAAAGCAGCCAAGGAAAAGTACGGGCTGACGGACAGGATGCTGGAG

TGCTACGATAAGGGAATGCATAAATCAGGGTCAGCTTTTGACTTGGGCTTTTGCC

ATGAGCTAATCGATTACTACAAGCGCTGTATCGCCGAGTATCCAGGATGGGACGT

TTTCGACTTTAAATTTCGGGAGACTTCTGATTATGGTTCAATGAAGGAGTTCAAC

GAAGATGTCGCTGGTGCCGGTTACTACATGAGCCTTCGCAAGATTCCTTGTTCCG

AAGTCTACCGGCTACTGGACGAGAAATCTATATATTTGTTCCAGATATATAACAA

GGACTACAGTGAGAATGCACATGGGAATAAGAATATGCATACTATGTATTGGGAA

GGTCTCTTTTCACCCCAAAATTTGGAGTCACCCGTGTTCAAACTTAGCGGTGGCG

CAGAGCTGTTCTTTAGGAAATCCAGTATACCCAATGACGCCAAGACAGTCCACCC

AAAGGGTAGCGTCCTGGTGCCCAGAAACGATGTGAACGGCAGGAGAATCCCTGAC

AGCATTTACCGAGAACTTACCAGGTACTTCAACCGCGGCGACTGTAGAATCTCTG

ATGAGGCAAAGTCTTATCTGGATAAGGTGAAGACTAAGAAGGCAGATCATGACAT

TGTGAAAGACCGCCGCTTTACTGTCGACAAAATGATGTTTCACGTGCCTATCGCA

ATGAATTTTAAGGCAATCTCAAAACCGAATCTGAACAAGAAGGTGATAGATGGCA

TTATCGATGACCAGGACCTCAAGATCATCGGAATCGACAGAGGTGAGCGAAACCT

GATATACGTCACAATGGTAGATCGGAAGGGTAATATTCTGTACCAGGATTCACTA

AACATCCTCAATGGATATGACTATCGAAAAGCTCTCGATGTCAGGGAATACGACA

ACAAGGAGGCGCGACGGAATTGGACAAAGGTGGAAGGCATACGGAAGATGAAGGA

AGGCTATCTGTCACTAGCTGTCTCCAAATTGGCTGATATGATTATAGAGAACAAC

GCCATTATCGTGATGGAAGATCTCAACCATGGATTCAAGGCAGGAAGAAGTAAAA

TTGAGAAGCAGGTGTATCAGAAGTTCGAAAGCATGCTTATTAATAAGTTGGGTTA

TATGGTCTTAAAGGACAAGTCTATCGATCAGAGCGGCGGCGCACTCCATGGGTAT

CAGCTGGCTAACCATGTCACCACACTAGCATCCGTAGGCAAACAGTGTGGCGTGA

TTTTCTACATTCCTGCTGCGTTCACTTCTAAGATCGATCCTACCACGGGATTCGC

AGACCTGTTCGCACTGAGCAATGTTAAAAACGTGGCCTCCATGAGGGAGTTCTTT

AGCAAAATGAAAAGCGTGATTTATGACAAGGCCGAGGGCAAGTTCGCTTTCACAT

TTGACTACCTGGACTACAATGTGAAATCAGAGTGCGGGAGAACCCTGTGGACCGT

ATACACGGTAGGGGAAAGATTCACTTACAGTCGAGTTAATCGGGAGTATGTCCGT

AAAGTGCCAACTGACATCATCTACGATGCCCTTCAGAAGGCTGGCATAAGTGTTG

AGGGGGATCTAAGGGACAGGATCGCTGAATCGGATGGCGATACTCTCAAATCAAT

CTTCTACGCCTTCAAGTATGCCCTCGACATGAGGGTAGAGAACCGGGAGGAGGAC

TATATACAGTCTCCCGTGAAGAATGCGTCGGGAGAGTTCTTCTGCTCAAAAAACG

CCGGGAAATCTTTGCCGCAGGATTCTGATGCAAATGGGGCTTATAACATTGCTCT

CAAAGGCATCCTGCAGCTGCGCATGCTATCTGAACAATATGACCCAAACGCTGAA

AGCATTAGATTGCCATTGATCACCAATAAGGCTTGGCTGACTTTCATGCAGAGCG

GTATGAAGACATGGAAAAACTAA

SEQ
ATGGATTCCCTTAAGGACTTCACAAATCTTTACCCCGTGAGTAAAACCCTGAGAT

ID
TTGAACTCAAGCCCGTGGGAAAGACTCTCGAGAATATCGAGAAGGCCGGGATTTT

NO:
GAAGGAAGACGAGCATCGGGCGGAAAGTTACAGACGGGTGAAGAAGATTATAGAT

152
ACTTATCACAAGGTCTTTATAGACAGCTCTTTAGAGAACATGGCAAAGATGGGCA

TCGAGAACGAAATCAAGGCCATGCTGCAGTCCTTCTGCGAGCTGTATAAAAAGGA

TCATCGGACCGAAGGCGAAGACAAGGCGCTGGATAAGATCAGGGCAGTGCTGCGC

GGCCTCATTGTGGGTGCCTTCACTGGGGTGTGCGGGCGGAGAGAGAACACTGTGC

AGAATGAGAAATACGAGAGTTTGTTCAAAGAGAAACTCATCAAGGAAATCCTGCC

CGACTTCGTCTTAAGCACAGAAGCCGAATCTCTCCCATTTTCTGTCGAGGAGGCC

ACGCGTTCCCTTAAAGAGTTCGACAGTTTCACTTCATACTTTGCCGGATTTTATG

AAAACCGTAAAAATATATACTCCACTAAACCACAGTCAACTGCAATAGCTTACAG

GTTAATCCACGAAAACCTGCCAAAATTCATCGACAATATACTCGTCTTTCAAAAA

ATCAAGGAACCAATCGCGAAGGAACTTGAACACATCCGGGCTGACTTTAGTGCGG

GAGGATACATCAAAAAAGACGAGCGCCTGGAGGATATATTTTCACTAAATTATTA

TATTCATGTACTGAGCCAGGCTGGCATAGAAAAGTACAACGCTCTAATTGGGAAA

ATCGTGACAGAAGGTGACGGGGAAATGAAAGGGCTAAACGAACATATTAACTTAT

ATAACCAACAGCGGGGTCGAGAAGATCGTCTGCCCCTGTTCAGACCTCTGTATAA

GCAAATACTCTCCGACAGAGAGCAGCTATCATATCTGCCCGAGTCCTTTGAGAAA

GATGAAGAGCTGCTCCGGGCGCTCAAGGAGTTCTATGATCATATAGCCGAGGACA

TTTTGGGCAGAACTCAGCAACTCATGACGTCTATTTCTGAATATGATCTGTCTCG

TATCTATGTCAGGAATGATAGCCAGCTGACCGATATATCCAAGAAGATGCTGGGG

GACTGGAACGCCATTTATATGGCGAGGGAGCGAGCATACGATCACGAGCAGGCAC

CCAAGAGAATCACAGCCAAATATGAGAGAGACCGCATTAAGGCGCTGAAGGGCGA

AGAAAGTATCAGTCTGGCCAATCTGAACTCCTGCATAGCTTTCCTTGATAACGTG

AGGGATTGCAGAGTTGATACTTACCTGAGTACCCTGGGCCAGAAGGAAGGGCCTC

ACGGCCTCTCTAATCTAGTGGAGAATGTATTTGCCTCCTACCACGAAGCTGAGCA

GCTGCTGTCATTTCCGTACCCAGAGGAAAATAATTTAATACAGGATAAGGACAAC

GTAGTGCTTATCAAAAATCTACTGGATAACATTTCCGACCTCCAGCGCTTTCTCA

AACCACTTTGGGGGATGGGCGACGAGCCTGATAAGGATGAGCGCTTTTACGGCGA

GTACAACTACATCAGGGGCGCCTTGGACCAGGTGATTCCCCTCTATAATAAAGTC

AGGAATTACCTGACCCGAAAGCCATACAGTACAAGAAAGGTGAAATTAAATTTCG

GCAATAGTCAGCTGCTGTCTGGTTGGGACCGAAATAAGGAGAAAGACAACAGCTG

CGTAATTCTCAGAAAAGGACAGAACTTTTATTTGGCCATCATGAATAACAGACAC

AAGAGATCTTTCGAGAACAAAGTGCTCCCTGAGTATAAGGAGGGGGAACCCTACT

TCGAGAAGATGGACTATAAATTCCTTCCTGATCCAAATAAAATGCTGCCTAAAGT

ATTTCTGTCAAAAAAAGGTATAGAAATCTACAAACCTTCACCTAAGCTACTTGAA

CAGTATGGCCACGGCACCCATAAAAAAGGGGACACGTTCAGCATGGACGACCTAC

ACGAACTGATTGACTTCTTTAAGCACAGCATAGAAGCTCATGAGGACTGGAAACA

GTTCGGATTCAAATTCTCAGATACCGCGACCTACGAAAACGTGTCTAGTTTTTAC

CGGGAAGTCGAGGACCAGGGCTACAAGCTCAGCTTCAGAAAAGTTAGCGAATCTT

ACGTCTACTCCCTTATAGATCAAGGTAAGCTGTATCTCTTTCAAATCTACAACAA

GGACTTTTCCCCATGTAGCAAGGGCACCCCCAATCTGCACACTCTCTACTGGCGG

ATGCTGTTCGACGAGCGTAACCTGGCAGACGTGATCTACAAATTAGATGGTAAAG

CTGAGATCTTCTTTCGTGAAAAGAGCCTAAAGAACGATCACCCCACTCACCCCGC

CGGAAAGCCCATTAAGAAGAAAAGTAGGCAGAAGAAAGGAGAAGAATCGCTATTT

GAGTACGACCTCGTCAAGGATCGGCATTATACAATGGATAAGTTCCAGTTCCATG

TGCCAATAACTATGAATTTCAAGTGCAGTGCTGGCAGTAAGGTGAATGACATGGT

AAACGCTCATATCCGGGAGGCAAAGGACATGCATGTTATTGGAATTGATAGGGGT

GAGCGTAATCTCCTCTACATCTGTGTTATTGACTCCCGCGGCACAATCCTCGATC

AGATTTCCTTGAATACAATTAATGATATAGACTACCATGACTTGCTTGAGTCTCG

CGACAAAGATAGACAGCAGGAGAGAAGAAATTGGCAGACCATCGAAGGCATCAAG

GAACTCAAGCAAGGCTACCTTTCTCAGGCAGTGCATCGAATAGCCGAGCTGATGG

TGGCTTATAAAGCCGTCGTGGCACTAGAAGACCTAAATATGGGATTTAAACGAGG

CAGGCAGAAGGTGGAATCATCCGTATACCAGCAGTTCGAAAAACAGTTGATAGAC

AAACTCAATTACCTTGTAGACAAGAAGAAGCGGCCTGAGGACATAGGGGGCCTGC

TTAGAGCGTATCAATTTACAGCCCCATTCAAGTCTTTCAAAGAAATGGGTAAACA

GAACGGTTTTCTGTTTTACATCCCAGCGTGGAACACCAGCAATATAGATCCAACC

ACTGGCTTCGTCAATCTGTTTCATGCTCAGTATGAAAATGTGGACAAGGCCAAAT

CCTTCTTTCAGAAATTTGACAGCATCTCCTATAACCCAAAGAAAGACTGGTTTGA

ATTCGCCTTTGACTATAAGAATTTCACTAAGAAGGCCGAGGGATCAAGAAGCATG

TGGATATTGTGCACGCATGGCTCACGTATAAAGAACTTTAGAAACTCGCAAAAAA

ACGGGCAGTGGGACTCAGAAGAATTCGCACTCACCGAGGCTTTCAAATCCCTCTT

CGTCCGGTATGAGATCGATTACACCGCCGATCTGAAGACGGCAATCGTCGACGAG

AAACAGAAAGACTTCTTTGTAGATCTACTTAAGCTCTTTAAGCTAACCGTTCAGA

TGCGAAACAGTTGGAAAGAAAAGGATCTCGACTATCTCATTAGTCCAGTGGCTGG

CGCGGATGGTAGATTTTTCGATACCCGGGAAGGTAACAAGTCCCTTCCCAAAGAC

GCCGACGCGAATGGTGCCTACAATATTGCACTAAAGGGGCTCTGGGCGCTGCGGC

AAATTAGACAGACATCTGAAGGGGGCAAGCTTAAGCTGGCTATTTCTAATAAAGA

GTGGTTGCAGTTTGTGCAGGAAAGGAGTTATGAGAAGGACTAG

SEQ
ATGAACAACGGCACCAACAACTTCCAGAACTTCATCGGCATATCGTCTCTGCAGA

ID
AAACACTTAGGAATGCCCTGATTCCAACTGAGACAACACAGCAGTTTATTGTGAA

NO:
GAATGGGATCATCAAAGAGGACGAATTGCGCGGGGAGAATAGGCAGATCCTGAAG

153
GACATCATGGACGATTACTACAGGGGTTTTATCTCCGAAACGCTGAGCTCGATTG

ACGATATTGACTGGACGTCCCTCTTTGAGAAGATGGAAATCCAACTTAAAAATGG

CGATAATAAAGATACCCTGATAAAGGAACAAACCGAATATAGAAAGGCTATACAC

AAAAAATTCGCAAATGACGACCGCTTTAAGAACATGTTTTCTGCAAAACTGATTA

GCGATATTCTGCCCGAGTTTGTGATTCACAATAATAACTATTCCGCTTCGGAGAA

GGAGGAAAAGACTCAGGTGATTAAACTGTTTTCTCGGTTCGCCACTTCTTTCAAA

GATTATTTCAAAAATCGCGCCAACTGTTTTTCCGCTGACGACATCTCCTCCTCTT

CCTGCCACCGGATCGTAAACGACAATGCCGAGATCTTTTTTAGTAACGCCCTTGT

GTATCGGAGGATAGTGAAGAGCCTGTCCAATGATGACATAAACAAAATTTCTGGC

GATATGAAGGATAGCCTCAAAGAGATGAGCCTTGAAGAAATTTACTCCTACGAGA

AGTATGGGGAGTTCATCACCCAGGAGGGGATTTCCTTCTATAATGACATCTGTGG

CAAGGTGAACAGCTTCATGAACCTGTACTGCCAGAAGAATAAGGAAAACAAAAAT

CTGTACAAGCTTCAGAAGTTACATAAGCAGATCCTGTGTATCGCGGATACCTCAT

ATGAGGTTCCTTATAAGTTCGAGAGTGATGAAGAAGTGTACCAGTCTGTAAATGG

ATTCTTAGACAATATTTCGTCCAAACATATAGTGGAGAGACTGAGAAAGATCGGG

GACAATTACAATGGGTACAATCTCGACAAGATTTATATCGTGTCGAAGTTTTACG

AATCTGTGAGCCAGAAAACATACAGGGATTGGGAAACCATTAATACCGCGCTTGA

AATTCACTACAATAATATTCTGCCTGGCAACGGAAAAAGCAAGGCCGATAAGGTA

AAAAAGGCAGTCAAAAATGACCTTCAGAAAAGTATCACCGAAATCAATGAGTTGG

TGAGCAACTACAAATTGTGTTCAGACGATAATATTAAAGCGGAAACGTACATACA

TGAAATTAGCCATATTCTGAATAACTTTGAGGCGCAGGAACTTAAGTACAACCCT

GAAATTCATCTCGTCGAAAGCGAATTGAAGGCCTCTGAATTGAAAAACGTTCTTG

ACGTGATAATGAACGCTTTCCATTGGTGCTCTGTGTTTATGACTGAAGAGCTGGT

TGATAAGGACAACAACTTTTATGCTGAACTTGAGGAAATCTACGACGAGATCTAC

CCTGTGATTAGCTTGTATAACCTCGTCAGAAACTACGTTACCCAGAAGCCGTACA

GCACGAAAAAAATAAAGCTGAACTTTGGTATTCCGACTCTCGCCGATGGATGGAG

CAAGTCGAAGGAATATTCCAACAATGCCATCATTCTTATGCGAGACAATCTGTAT

TACCTCGGCATCTTTAACGCCAAAAACAAGCCGGATAAGAAAATCATTGAAGGGA

ATACGAGCGAGAATAAGGGCGACTATAAGAAAATGATCTACAACTTACTGCCAGG

TCCCAATAAAATGATTCCTAAGGTGTTTCTGTCATCGAAAACAGGTGTAGAAACA

TATAAGCCCAGCGCATACATCCTGGAAGGCTACAAGCAAAACAAACACATCAAAA

GCAGCAAGGACTTTGATATCACATTCTGCCACGATCTAATCGACTACTTCAAAAA

TTGCATCGCCATTCACCCTGAGTGGAAGAACTTCGGCTTTGACTTCTCCGACACC

AGTACCTACGAAGACATTTCTGGATTCTACCGTGAGGTTGAGCTGCAGGGTTATA

AAATTGACTGGACATACATCAGTGAAAAAGACATCGATCTACTGCAGGAGAAGGG

GCAGCTCTATCTCTTCCAGATTTATAATAAGGATTTCAGCAAGAAGTCCACTGGA

AACGACAATCTGCATACAATGTATCTTAAGAACTTGTTTAGCGAAGAGAATTTGA

AAGATATCGTTCTAAAGTTAAACGGGGAAGCCGAGATTTTCTTTCGAAAGTCTTC

CATTAAGAATCCAATTATTCACAAGAAGGGCAGTATCCTGGTCAACAGAACCTAT

GAGGCCGAGGAAAAGGACCAGTTCGGTAATATACAAATTGTGCGCAAGAACATCC

CCGAGAACATTTACCAGGAGCTCTATAAATACTTCAACGACAAAAGCGATAAGGA

GCTTTCCGACGAGGCTGCCAAGCTGAAAAACGTGGTGGGACACCATGAAGCAGCC

ACCAACATCGTCAAAGATTATCGTTATACATATGACAAATATTTTCTGCACATGC

CTATTACAATAAACTTTAAGGCAAACAAGACCGGGTTCATCAATGACCGGATACT

CCAGTACATCGCAAAAGAGAAGGACCTGCATGTGATCGGCATCGACCGCGGTGAA

AGAAATCTCATTTACGTCAGCGTTATCGACACTTGTGGAAACATTGTGGAGCAGA

AGTCCTTCAACATTGTTAACGGCTATGACTATCAGATCAAGCTCAAACAGCAGGA

AGGTGCTCGTCAGATTGCGAGGAAAGAATGGAAAGAGATCGGCAAGATCAAGGAG

ATCAAAGAAGGGTATCTGAGCTTGGTCATTCACGAGATCTCCAAAATGGTCATCA

AGTACAACGCTATTATCGCGATGGAAGACCTCTCTTACGGCTTTAAGAAGGGGCG

CTTTAAAGTGGAGCGCCAGGTCTATCAGAAGTTCGAGACTATGCTTATCAATAAG

CTGAATTACTTGGTCTTTAAGGATATCAGTATCACCGAGAACGGAGGACTGCTGA

AAGGTTACCAGCTCACATATATTCCCGATAAGCTCAAGAATGTGGGCCACCAATG

CGGTTGTATTTTTTACGTTCCAGCTGCCTACACATCTAAGATCGATCCTACCACC

GGATTCGTCAATATATTTAAATTTAAAGATCTAACCGTTGATGCCAAGCGTGAGT

TTATTAAGAAATTTGATTCAATCAGGTACGACAGCGAAAAGAACCTCTTCTGTTT

CACTTTCGACTACAACAACTTCATCACACAAAATACTGTGATGAGCAAGTCATCA

TGGAGCGTTTATACTTATGGTGTAAGGATAAAAAGGCGCTTTGTTAATGGAAGGT

TTTCCAATGAAAGCGATACAATAGACATCACAAAAGACATGGAGAAGACACTGGA

GATGACAGATATTAATTGGAGGGACGGGCATGACCTTAGACAGGACATCATCGAC

TACGAAATCGTCCAACACATTTTTGAGATATTCAGACTCACTGTCCAGATGCGAA

ACAGCCTGTCGGAACTCGAAGACCGGGACTACGATAGACTGATCTCCCCGGTGTT

AAACGAAAATAATATTTTCTACGATTCTGCTAAGGCAGGAGACGCTCTTCCTAAA

GATGCGGACGCCAATGGCGCTTACTGTATAGCGTTGAAGGGATTGTATGAGATTA

AACAGATCACTGAGAATTGGAAAGAAGACGGTAAATTCTCCAGAGACAAGCTGAA

AATCTCCAACAAAGACTGGTTTGATTTTATTCAAAATAAGCGCTACCTGTAA

SEQ
ATGACAAACAAATTTACTAATCAGTACAGCCTGTCAAAGACCCTCCGCTTCGAAC

ID
TGATTCCACAAGGGAAGACCCTTGAATTCATCCAGGAAAAGGGTTTATTATCCCA

NO:
GGATAAACAACGCGCAGAAAGCTATCAAGAGATGAAGAAGACGATCGATAAATTT

154
CATAAGTATTTCATAGATTTAGCCCTGAGCAACGCTAAATTGACCCACCTGGAAA

CCTATTTGGAGCTGTACAACAAGTCAGCCGAGACAAAGAAAGAGCAGAAGTTTAA

GGACGACCTGAAAAAAGTACAGGACAATTTGCGAAAAGAGATCGTCAAGTCTTTT

TCCGACGGAGACGCCAAGTCAATATTTGCCATCCTGGACAAAAAGGAACTCATCA

CTGTGGAGTTGGAGAAGTGGTTTGAGAATAATGAGCAGAAGGACATCTATTTTGA

CGAAAAGTTCAAGACATTTACTACTTACTTCACCGGATTTCACCAAAACCGGAAG

AACATGTACTCTGTTGAGCCGAACTCAACCGCCATCGCCTACCGCCTTATTCACG

AAAATCTGCCAAAGTTTCTCGAGAATGCTAAAGCCTTTGAGAAAATTAAGCAGGT

CGAGTCGCTCCAGGTGAACTTTCGAGAGCTGATGGGTGAATTCGGGGACGAGGGC

CTGATTTTCGTGAATGAACTCGAAGAGATGTTTCAGATCAACTACTATAATGATG

TACTCTCACAGAACGGGATCACTATCTACAACAGCATTATCTCTGGATTCACTAA

GAACGATATCAAGTATAAAGGGCTGAATGAATACATCAACAATTATAATCAGACT

AAGGACAAAAAGGACAGGCTGCCTAAATTGAAACAGCTGTATAAGCAGATCCTCA

GTGATAGAATTAGCTTGTCATTTCTCCCAGATGCCTTCACTGACGGAAAGCAGGT

GCTTAAGGCGATATTCGATTTCTATAAGATCAACCTCCTCTCTTATACAATCGAG

GGCCAGGAGGAGTCACAGAACCTCCTGCTCCTGATTCGACAAACTATTGAAAATC

TGTCCTCTTTCGATACGCAGAAGATATACCTGAAAAATGACACCCATCTCACTAC

AATATCCCAACAGGTATTCGGAGATTTCTCCGTCTTCAGTACAGCCCTGAATTAC

TGGTACGAGACAAAGGTGAACCCTAAGTTCGAAACAGAGTACAGCAAGGCGAACG

AAAAGAAGAGGGAGATCCTGGACAAAGCCAAAGCCGTTTTCACCAAGCAAGATTA

CTTTAGCATCGCATTTCTGCAGGAAGTCCTGTCTGAGTACATACTGACACTCGAT

CACACAAGCGACATAGTTAAGAAGCACTCTTCCAATTGTATCGCGGACTACTTCA

AAAATCATTTTGTCGCGAAAAAGGAGAACGAGACAGATAAGACCTTCGATTTTAT

CGCGAATATTACCGCAAAGTATCAATGCATTCAGGGTATCTTGGAGAACGCCGAC

CAGTACGAAGACGAGCTTAAACAGGATCAGAAGCTCATCGACAACCTAAAGTTCT

TTTTGGACGCTATACTGGAACTCCTTCATTTTATTAAGCCACTACATCTGAAGAG

TGAGTCTATCACTGAGAAGGACACTGCTTTTTACGACGTTTTCGAGAATTACTAC

GAAGCACTGTCTCTGCTAACCCCTCTGTATAACATGGTGAGAAACTATGTGACAC

AGAAACCTTATAGTACCGAGAAGATTAAGTTGAACTTCGAGAACGCACAATTGCT

GAATGGGTGGGATGCAAACAAAGAGGGTGATTACCTCACAACAATCCTCAAGAAA

GATGGCAATTACTTCCTGGCCATTATGGATAAAAAACATAACAAGGCATTTCAGA

AATTTCCCGAGGGGAAGGAAAATTATGAAAAGATGGTATACAAGTTGCTGCCCGG

GGTGAACAAAATGCTCCCGAAGGTGTTTTTCTCGAATAAGAATATCGCGTACTTT

AACCCGTCCAAGGAACTGTTGGAAAATTATAAAAAGGAAACACACAAGAAGGGGG

ACACTTTTAATTTGGAGCACTGCCACACACTCATTGACTTCTTTAAAGATAGTCT

CAACAAACATGAGGATTGGAAATATTTTGACTTTCAGTTTAGCGAGACCAAGTCT

TATCAGGATCTGTCGGGATTTTATAGGGAAGTTGAGCACCAGGGTTACAAGATAA

ATTTCAAGAACATCGATAGCGAGTACATTGACGGACTGGTGAACGAAGGGAAGCT

GTTCCTGTTTCAGATTTACAGCAAAGATTTCTCTCCTTTCTCAAAAGGCAAGCCG

AACATGCATACCCTGTATTGGAAGGCCCTGTTCGAGGAGCAAAACCTTCAGAATG

TGATTTACAAGCTGAACGGTCAGGCCGAGATTTTTTTTAGGAAGGCCTCTATCAA

GCCCAAAAACATCATTCTGCACAAGAAAAAGATAAAGATCGCCAAAAAACACTTC

ATTGATAAAAAGACAAAGACTTCTGAGATCGTACCTGTTCAGACAATCAAGAATC

TCAACATGTATTATCAGGGGAAGATTAGCGAGAAAGAGCTGACACAGGACGATTT

GAGGTACATCGACAACTTCTCTATCTTTAACGAGAAGAACAAGACAATCGATATC

ATCAAGGACAAGCGGTTTACCGTCGATAAATTCCAGTTCCATGTGCCTATCACGA

TGAATTTCAAGGCCACCGGTGGGAGTTATATCAACCAGACTGTGCTGGAGTATCT

GCAGAACAACCCCGAAGTAAAAATTATTGGCCTGGACAGAGGAGAGCGGCATCTG

GTGTACTTGACCCTCATCGATCAGCAGGGAAATATCCTGAAACAAGAATCTCTGA

ATACTATTACGGACTCCAAAATCAGCACACCTTACCACAAGCTGCTTGATAATAA

AGAGAATGAGAGGGACTTGGCCCGCAAAAATTGGGGCACCGTCGAGAATATTAAG

GAATTGAAAGAAGGATACATCTCACAGGTGGTTCACAAAATCGCAACCCTGATGT

TAGAAGAGAACGCTATTGTGGTGATGGAGGACTTAAACTTCGGATTTAAAAGAGG

AAGATTTAAAGTCGAGAAACAGATTTATCAGAAACTGGAAAAAATGCTCATTGAC

AAATTAAATTACCTGGTGCTGAAAGATAAACAGCCACAGGAGCTGGGTGGCCTGT

ATAATGCTCTGCAGCTGACCAACAAGTTCGAGTCGTTTCAGAAAATGGGCAAGCA

GTCAGGCTTCCTTTTTTACGTGCCCGCTTGGAACACCTCAAAAATCGACCCTACA

ACAGGCTTTGTGAATTATTTCTATACCAAGTATGAAAACGTGGACAAGGCAAAGG

CCTTTTTCGAGAAGTTTGAAGCAATCAGGTTCAATGCCGAGAAAAAATACTTTGA

GTTCGAGGTCAAAAAATATAGCGACTTCAACCCTAAGGCCGAAGGCACGCAACAA

GCCTGGACAATATGCACGTATGGGGAGAGAATTGAGACTAAGCGGCAGAAGGATC

AGAATAACAAATTCGTGAGCACACCGATTAACCTGACAGAGAAGATAGAGGACTT

CCTCGGCAAGAATCAGATCGTGTACGGCGACGGCAATTGCATCAAGTCACAAATT

GCATCTAAAGATGACAAAGCATTCTTCGAAACACTGCTGTATTGGTTCAAGATGA

CACTCCAGATGCGAAATAGCGAAACAAGAACAGATATTGACTACCTCATCAGCCC

TGTGATGAATGATAACGGCACGTTTTACAATTCCCGGGACTATGAAAAATTAGAG

AACCCGACACTGCCAAAAGACGCCGACGCAAATGGTGCATATCACATCGCAAAGA

AAGGTTTGATGCTGTTGAACAAAATTGATCAGGCTGATCTGACAAAAAAGGTCGA

TCTGAGTATCAGTAACCGCGACTGGTTGCAGTTTGTCCAGAAGAACAAATAA

SEQ
ATGGAACAAGAGTACTATCTGGGCCTGGACATGGGCACCGGGAGTGTCGGATGGG

ID
CAGTCACCGACTCAGAGTACCACGTCCTCAGAAAGCACGGTAAGGCACTTTGGGG

NO:
AGTGCGACTCTTCGAGTCCGCTAGTACTGCTGAAGAGAGGAGGATGTTTCGAACT

155
TCCAGGCGCAGGCTGGATCGGCGAAACTGGAGAATAGAGATTCTCCAGGAGATAT

TTGCTGAAGAGATTTCAAAGAAGGATCCTGGTTTTTTCCTGCGCATGAAAGAATC

TAAGTATTACCCCGAAGATAAACGCGACATCAACGGCAATTGTCCTGAACTGCCC

TATGCTCTGTTTGTCGACGACGATTTCACCGACAAAGATTACCACAAGAAATTCC

CCACCATATACCACCTGAGAAAGATGTTGATGAACACCGAGGAGACACCCGACAT

ACGTCTGGTTTACCTGGCTATCCATCATATGATGAAGCACCGCGGGCATTTCCTG

CTGTCTGGAGACATCAATGAGATAAAGGAATTTGGTACTACGTTCTCCAAGTTGT

TAGAAAACATTAAGAATGAAGAGTTGGACTGGAATCTTGAACTGGGAAAGGAAGA

GTATGCAGTTGTAGAGTCGATTTTGAAAGATAACATGTTAAACCGGTCAACTAAG

AAAACCAGGTTAATTAAGGCACTAAAGGCCAAATCGATATGCGAGAAGGCTGTGC

TAAATCTGCTGGCTGGAGGCACCGTGAAACTGTCTGATATTTTCGGCCTGGAAGA

GCTCAATGAAACCGAGCGGCCTAAAATTTCTTTCGCCGATAACGGATACGATGAC

TATATTGGGGAGGTGGAAAACGAGCTCGGAGAACAATTCTACATTATTGAAACCG

CTAAGGCAGTCTATGACTGGGCCGTGCTCGTCGAGATTTTAGGCAAGTACACCAG

CATTAGCGAAGCAAAGGTGGCTACCTATGAAAAGCACAAATCTGACCTCCAGTTT

CTGAAAAAGATTGTGCGCAAATACTTAACAAAAGAAGAGTACAAGGACATCTTTG

TGAGCACATCAGATAAGCTCAAGAATTACTCAGCATACATTGGAATGACAAAGAT

TAACGGGAAGAAGGTGGATCTCCAAAGCAAACGTTGTTCAAAGGAGGAGTTTTAC

GATTTCATAAAGAAGAACGTGCTGAAGAAACTGGAGGGACAACCGGAGTACGAGT

ATTTAAAGGAGGAGCTCGAGCGAGAAACTTTCCTGCCCAAGCAAGTGAACAGAGA

CAATGGTGTCATTCCTTACCAGATTCACTTATATGAGCTGAAGAAAATCCTGGGG

AACTTGAGAGACAAGATAGACCTCATCAAGGAAAATGAAGATAAGTTGGTCCAGT

TGTTCGAATTCAGAATCCCATATTACGTCGGCCCGCTCAATAAGATCGACGACGG

CAAGGAAGGCAAATTCACTTGGGCGGTGCGAAAAAGCAACGAAAAAATATACCCA

TGGAACTTTGAGAACGTCGTTGACATCGAGGCCAGCGCCGAGAAATTTATAAGAC

GCATGACTAATAAGTGTACTTACCTCATGGGCGAGGATGTTCTGCCCAAGGACAG

CCTGCTGTATTCCAAGTACATGGTGCTTAACGAGCTGAATAATGTAAAGTTAGAT

GGTGAGAAGCTCAGCGTGGAGCTTAAACAGAGGCTGTACACTGATGTGTTTTGCA

AGTATCGGAAAGTTACCGTTAAGAAGATAAAGAATTACCTGAAATGCGAAGGGAT

CATTTCCGGCAACGTGGAAATTACCGGAATCGACGGCGATTTTAAGGCGTCGTTG

ACCGCTTATCATGATTTCAAGGAGATTTTAACCGGCACGGAGCTCGCGAAGAAAG

ACAAGGAGAACATAATCACGAATATAGTTCTGTTTGGGGACGATAAAAAACTTCT

TAAAAAACGACTCAATCGACTGTATCCGCAGATTACCCCCAACCAGCTGAAGAAG

ATTTGCGCTCTGAGCTATACCGGGTGGGGCCGGTTCTCTAAGAAATTCCTCGAGG

AGATCACAGCACCAGACCCAGAGACTGGTGAGGTGTGGAATATTATTACAGCTCT

GTGGGAATCCAATAATAACCTTATGCAATTGTTGAGCAATGAATATAGGTTCATG

GAGGAAGTGGAAACCTACAATATGGGCAAGCAGACAAAGACCCTATCTTACGAGA

CCGTTGAGAATATGTATGTCTCCCCTTCAGTGAAACGGCAAATCTGGCAAACTTT

GAAGATCGTGAAGGAGCTCGAAAAGGTGATGAAAGAGAGCCCGAAGAGGGTTTTT

ATTGAAATGGCCAGAGAGAAACAGGAGAGCAAGAGAACAGAGTCTAGGAAGAAGC

AGCTAATCGATTTGTATAAAGCCTGCAAGAACGAGGAAAAAGACTGGGTCAAGGA

GCTAGGCGATCAGGAAGAACAGAAGTTGCGCTCTGATAAGCTGTACTTATATTAT

ACCCAGAAAGGACGGTGCATGTACTCAGGTGAGGTCATTGAGCTGAAAGATCTGT

GGGACAATACTAAGTATGATATTGATCACATCTACCCTCAGTCAAAAACTATGGA

CGACTCCCTCAACAACAGGGTGTTGGTTAAGAAGAAATACAATGCTACAAAGTCC

GATAAATACCCTCTTAACGAAAACATCCGGCACGAAAGAAAGGGCTTCTGGAAGT

CCCTGCTGGATGGGGGTTTTATCAGTAAAGAAAAGTATGAGAGGCTGATCCGAAA

TACCGAGCTCTCCCCCGAGGAACTGGCTGGCTTTATCGAAAGGCAGATCGTAGAG

ACTAGGCAATCTACAAAGGCAGTCGCTGAGATCCTGAAGCAAGTGTTTCCTGAGT

CAGAAATCGTGTACGTCAAAGCTGGCACAGTGTCACGGTTCCGAAAGGACTTTGA

GTTGTTAAAAGTTCGGGAGGTGAATGACCTGCACCACGCTAAAGACGCCTATCTG

AATATCGTTGTGGGGAACTCCTATTATGTTAAGTTTACTAAGAATGCGTCCTGGT

TTATTAAGGAGAACCCGGGGCGCACCTATAACCTGAAGAAGATGTTCACCTCCGG

CTGGAACATAGAACGGAACGGAGAAGTCGCGTGGGAGGTGGGTAAGAAAGGGACC

ATTGTGACCGTCAAACAGATTATGAACAAAAACAACATATTGGTAACTCGCCAGG

TGCATGAGGCCAAAGGGGGCCTCTTTGATCAGCAGATTATGAAAAAGGGCAAAGG

ACAGATCGCAATCAAGGAAACCGACGAGCGCCTGGCATCCATTGAGAAGTACGGA

GGCTACAACAAGGCGGCAGGTGCGTACTTCATGCTCGTCGAGTCCAAAGATAAGA

AAGGCAAAACTATTAGAACAATCGAGTTCATCCCTCTATATTTGAAAAATAAGAT

CGAAAGTGACGAAAGCATCGCCCTTAACTTCTTGGAGAAGGGCCGGGGCTTAAAG

GAACCAAAGATTCTGCTCAAGAAGATCAAGATCGACACACTCTTCGATGTGGATG

GTTTTAAGATGTGGCTGTCAGGCAGGACAGGGGATCGCTTGCTGTTCAAATGCGC

AAATCAGTTGATTCTGGACGAAAAGATCATTGTGACGATGAAGAAGATCGTTAAA

TTCATTCAGCGGAGACAGGAAAACAGAGAACTGAAACTCTCCGATAAGGATGGAA

TTGACAATGAAGTCCTCATGGAGATTTACAATACCTTTGTGGACAAGCTTGAGAA

CACAGTCTATCGGATCCGACTGTCCGAACAGGCAAAGACTCTGATCGACAAACAG

AAAGAATTCGAAAGACTAAGCTTAGAGGACAAAAGTTCAACTCTCTTTGAAATTC

TCCACATCTTCCAATGTCAAAGTAGTGCAGCCAACTTGAAGATGATCGGGGGTCC

CGGCAAGGCTGGAATCTTAGTCATGAACAACAACATCTCCAAATGTAACAAAATC

TCCATCATAAACCAGTCTCCCACCGGCATTTTCGAGAACGAAATTGATTTACTCA

AG

SEQ
ATGAAATCTTTCGATTCTTTCACCAACCTCTACTCCCTTAGCAAAACCCTTAAGT

ID
TTGAAATGAGGCCGGTGGGGAATACACAGAAGATGCTTGACAATGCTGGCGTCTT

NO:
TGAAAAGGACAAATTAATCCAGAAGAAGTATGGTAAAACAAAGCCATATTTTGAC

156
CGATTGCATCGGGAATTCATTGAAGAGGCTCTTACAGGAGTAGAATTGATCGGAC

TGGACGAGAACTTCCGTACCTTAGTAGACTGGCAGAAGGACAAGAAGAACAACGT

GGCAATGAAGGCCTATGAGAACTCACTCCAGCGCCTTAGAACCGAGATCGGAAAG

ATCTTTAATCTTAAGGCGGAAGATTGGGTAAAAAATAAGTACCCGATCCTGGGAC

TGAAAAACAAAAACACAGACATCCTGTTTGAAGAAGCCGTCTTTGGTATCTTGAA

GGCCAGGTATGGAGAGGAGAAAGACACGTTTATAGAGGTAGAGGAGATTGATAAA

ACAGGCAAGAGTAAGATTAATCAGATCAGTATCTTTGATTCTTGGAAGGGGTTCA

CAGGCTACTTTAAGAAGTTTTTCGAAACCAGGAAAAATTTCTATAAGAACGATGG

CACCTCCACAGCTATCGCGACACGCATCATAGATCAGAATCTGAAACGGTTCATT

GATAATCTGAGCATTGTTGAATCCGTGCGCCAGAAGGTCGACCTAGCTGAGACTG

AGAAGTCTTTCTCTATATCACTCTCCCAGTTCTTCTCAATAGATTTTTATAATAA

GTGCCTTCTGCAAGATGGCATAGACTACTATAACAAGATCATCGGCGGCGAAACT

CTCAAAAACGGTGAAAAGCTCATTGGCCTGAATGAGCTCATCAACCAATATAGAC

AAAATAACAAGGATCAGAAAATCCCATTCTTTAAGCTGCTAGATAAACAGATCCT

ATCAGAAAAAATCCTGTTCCTCGACGAAATCAAAAACGACACCGAACTCATCGAG

GCTCTCTCGCAGTTTGCCAAGACGGCTGAGGAGAAGACGAAGATTGTGAAAAAGC

TGTTTGCAGACTTTGTGGAGAACAACTCTAAATACGATTTGGCTCAGATTTATAT

CTCCCAGGAAGCATTTAACACAATCTCCAATAAGTGGACTAGCGAGACTGAAACC

TTCGCCAAATACCTGTTCGAGGCCATGAAAAGCGGCAAGCTCGCCAAATACGAGA

AGAAGGACAATTCCTATAAGTTTCCCGATTTCATCGCATTATCTCAGATGAAGTC

CGCGCTACTTAGCATTAGCCTGGAAGGCCATTTTTGGAAGGAGAAATACTATAAG

ATTTCCAAATTCCAAGAAAAGACCAATTGGGAGCAGTTCTTGGCTATTTTTCTAT

ACGAGTTCAACTCTTTGTTCAGTGACAAGATCAACACTAAGGACGGTGAGACCAA

ACAAGTGGGGTACTACCTCTTCGCCAAAGATCTTCATAACCTGATACTGTCCGAA

CAGATCGACATACCCAAGGATTCAAAGGTGACCATCAAGGATTTTGCGGATTCGG

TATTGACGATCTATCAGATGGCGAAGTATTTCGCTGTCGAGAAAAAGCGGGCATG

GCTGGCCGAATACGAGTTGGACTCCTTCTATACTCAACCCGATACAGGGTACCTG

CAGTTTTACGATAATGCATACGAGGATATAGTCCAGGTGTACAATAAACTCAGGA

ACTACCTCACTAAGAAACCATACTCCGAAGAAAAATGGAAACTTAATTTTGAGAA

TAGTACACTGGCCAATGGATGGGACAAGAACAAGGAATCAGACAACTCCGCTGTA

ATTCTCCAGAAGGGTGGCAAGTATTATCTGGGACTGATAACAAAGGGCCATAACA

AGATTTTCGATGACCGTTTTCAGGAGAAGTTTATAGTGGGCATAGAGGGTGGCAA

GTATGAAAAAATAGTCTACAAGTTCTTTCCCGATCAGGCGAAGATGTTCCCCAAA

GTATGCTTCAGTGCTAAAGGCCTCGAGTTTTTCCGGCCATCTGAAGAGATACTCC

GCATCTATAATAACGCAGAGTTTAAAAAGGGAGAGACGTACTCAATCGACTCGAT

GCAGAAACTCATTGACTTCTACAAAGATTGTCTCACAAAATACGAGGGCTGGGCT

TGCTACACGTTTCGGCACTTGAAGCCAACCGAGGAATATCAAAACAACATCGGGG

AGTTCTTCCGTGACGTCGCCGAAGACGGCTATAGAATTGACTTTCAGGGCATAAG

TGATCAGTATATTCACGAGAAGAATGAGAAAGGTGAGTTGCATCTTTTCGAAATC

CACAATAAAGACTGGAATCTTGACAAGGCTCGCGATGGAAAATCAAAGACTACCC

AGAAGAATCTTCATACACTTTACTTCGAGTCCCTCTTTTCCAACGACAACGTCGT

ACAGAATTTCCCAATAAAACTGAACGGCCAGGCCGAAATTTTTTACAGGCCCAAA

ACCGAAAAAGATAAACTGGAATCCAAGAAAGACAAGAAGGGAAATAAGGTGATAG

ATCACAAAAGGTATTCCGAGAACAAGATTTTTTTCCACGTACCTCTTACCCTGAA

CAGAACGAAGAACGACTCTTATAGATTCAATGCCCAGATAAACAACTTTCTCGCA

AACAACAAAGATATCAATATTATCGGCGTCGATAGAGGTGAGAAGCACTTGGTAT

ATTATTCTGTGATCACGCAAGCATCCGATATCTTGGAGTCCGGTTCTTTGAACGA

ACTGAATGGTGTCAACTACGCCGAGAAACTCGGTAAGAAAGCTGAGAATCGGGAG

CAGGCTAGAAGGGACTGGCAGGACGTTCAGGGTATCAAGGACCTGAAGAAGGGCT

ACATTTCTCAGGTGGTTCGAAAACTGGCTGATTTGGCCATTAAGCACAATGCAAT

CATCATTTTAGAAGATTTGAACATGCGGTTTAAACAAGTCAGGGGGGGGATAGAG

AAATCAATTTACCAACAGCTGGAAAAAGCTCTGATTGATAAACTCTCTTTTTTGG

TTGATAAGGGCGAAAAGAACCCCGAGCAAGCAGGACATCTCCTTAAAGCCTATCA

ACTGAGCGCACCTTTCGAGACATTCCAGAAGATGGGAAAGCAAACCGGCATCATT

TTCTATACCCAGGCTTCCTATACATCCAAGTCTGATCCAGTGACTGGGTGGAGAC

CCCATCTCTACCTCAAGTACTTTTCTGCCAAAAAAGCTAAGGACGACATTGCTAA

GTTCACAAAAATCGAGTTCGTGAACGACAGGTTCGAGCTGACTTATGACATAAAA

GATTTCCAGCAGGCCAAGGAGTACCCAAACAAGACAGTTTGGAAAGTGTGTTCCA

ATGTGGAGAGGTTTCGGTGGGACAAGAATCTGAATCAGAATAAAGGGGGATATAC

TCACTACACCAACATTACCGAGAACATCCAAGAGTTGTTCACCAAATACGGCATC

GACATTACTAAAGATCTGCTGACACAGATCTCCACCATCGATGAGAAGCAGAACA

CATCTTTCTTCCGGGATTTCATCTTTTATTTTAACTTGATCTGTCAGATTAGAAA

TACCGACGACAGTGAGATAGCTAAAAAAAACGGGAAAGACGATTTCATTCTCTCT

CCCGTGGAGCCGTTTTTTGACTCCCGCAAAGACAATGGCAATAAGCTTCCGGAAA

ACGGGGACGATAACGGCGCCTACAACATCGCTCGTAAGGGAATCGTTATCCTCAA

TAAAATAAGCCAGTATTCCGAGAAGAACGAGAATTGTGAAAAAATGAAGTGGGGG

GACCTTTACGTCAGCAACATCGATTGGGATAACTTTGTGACACAAGCCAATGCGA

GACACTAG

SEQ
ATGGAAAACTTCAAAAACCTCTACCCCATCAACAAGACCTTGAGGTTTGAGCTCC

ID
GGCCATATGGGAAGACACTGGAGAACTTCAAAAAGTCCGGTCTGCTGGAAAAGGA

NO:
TGCTTTTAAGGCTAACTCTAGGAGGTCTATGCAGGCCATTATCGATGAGAAATTC

157
AAGGAGACCATAGAGGAGCGTCTGAAATATACTGAGTTTTCCGAGTGTGACCTAG

GAAATATGACCAGTAAGGACAAAAAGATCACCGACAAGGCAGCGACAAACCTGAA

GAAACAGGTGATTTTAAGCTTTGATGATGAGATTTTCAATAACTACTTGAAGCCG

GACAAAAACATCGACGCTCTGTTCAAGAATGATCCAAGCAACCCGGTCATCTCTA

CTTTCAAGGGCTTCACCACATACTTTGTAAATTTCTTCGAAATACGGAAACACAT

CTTCAAGGGAGAGTCTTCCGGTAGCATGGCTTACAGAATAATCGATGAGAACCTA

ACTACATATCTAAACAATATCGAGAAGATCAAGAAATTGCCTGAAGAACTGAAAT

CTCAGCTTGAGGGAATCGATCAAATTGACAAACTGAACAACTATAACGAGTTCAT

CACCCAGTCCGGCATTACTCATTATAACGAAATTATTGGAGGGATTTCGAAGTCT

GAAAATGTCAAAATTCAAGGCATTAACGAAGGGATTAATCTTTACTGTCAAAAGA

ATAAAGTGAAGCTACCACGCTTAACTCCTCTGTATAAGATGATTCTCTCTGATCG

GGTCTCTAATTCCTTTGTGCTGGATACCATTGAAAATGATACCGAGTTAATTGAA

ATGATCTCTGATCTGATAAATAAGACAGAGATAAGTCAGGATGTTATTATGTCCG

ACATCCAAAATATTTTCATCAAATATAAACAACTCGGCAACTTGCCGGGGATTAG

CTACTCATCTATAGTGAATGCTATCTGTTCGGATTACGACAATAACTTTGGTGAC

GGCAAACGTAAAAAAAGCTATGAGAATGATCGCAAAAAACACCTCGAGACTAACG

TGTATAGCATTAACTATATCTCAGAGTTACTGACAGACACCGACGTCTCCAGCAA

CATAAAGATGCGGTACAAAGAGCTGGAGCAGAATTATCAGGTATGCAAGGAAAAT

TTCAACGCCACTAACTGGATGAACATCAAAAACATTAAGCAGTCTGAGAAAACCA

ATCTGATCAAGGACCTTCTTGACATCCTCAAGAGCATCCAGCGGTTTTATGATTT

GTTTGACATCGTGGATGAAGACAAAAATCCTAGTGCTGAGTTCTATACCTGGCTG

TCTAAAAACGCGGAGAAACTGGACTTCGAGTTTAATTCAGTGTACAACAAGAGCA

GGAACTACCTCACGAGAAAGCAGTACTCCGATAAAAAGATTAAGTTGAACTTCGA

TAGTCCTACTCTCGCCAAGGGGTGGGATGCGAACAAAGAAATTGATAATAGCACA

ATTATCATGAGGAAGTTCAACAACGACCGGGGCGATTACGATTACTTCTTGGGGA

TCTGGAATAAGAGCACACCTGCCAACGAAAAGATCATCCCATTAGAGGATAATGG

ACTGTTTGAAAAAATGCAATATAAGCTGTATCCCGATCCTAGTAAAATGCTGCCA

AAGCAATTCCTTTCTAAGATCTGGAAAGCTAAACATCCAACTACACCCGAGTTTG

ATAAGAAGTACAAAGAAGGTCGGCACAAGAAGGGGCCTGATTTTGAGAAAGAGTT

TCTGCACGAGTTGATCGATTGCTTTAAGCATGGATTGGTAAACCACGACGAAAAA

TATCAGGATGTGTTCGGGTTCAATCTGCGCAACACGGAAGACTACAACTCTTATA

CAGAGTTTCTGGAGGACGTCGAAAGGTGCAACTATAATCTTAGTTTCAATAAAAT

CGCTGACACGTCTAACTTGATAAATGATGGGAAACTCTATGTTTTTCAGATCTGG

AGCAAGGATTTCAGCATAGATAGCAAGGGAACAAAAAACTTGAACACAATATACT

TTGAATCCCTCTTCTCGGAGGAAAATATGATCGAGAAGATGTTCAAGCTCTCAGG

GGAAGCCGAAATATTCTATCGTCCAGCAAGTTTGAATTATTGTGAAGATATTATC

AAGAAGGGACACCACCACGCCGAACTGAAGGACAAATTCGACTATCCCATCATCA

AGGACAAGCGATATAGCCAGGACAAATTTTTTTTTCATGTCCCCATGGTTATCAA

CTACAAAAGCGAGAAGTTAAACTCCAAATCACTTAACAATAGGACGAACGAAAAT

TTAGGCCAATTCACGCACATCATCGGTATCGACCGCGGAGAGCGACATCTCATCT

ACCTGACCGTGGTGGATGTGTCCACCGGTGAGATCGTTGAGCAAAAGCACCTGGA

TGAAATTATAAATACAGATACAAAAGGCGTCGAGCATAAAACTCATTATCTCAAT

AAATTAGAAGAGAAGTCCAAGACGCGGGATAATGAAAGAAAGTCCTGGGAAGCAA

TCGAGACGATTAAGGAGCTGAAAGAAGGCTATATTAGCCACGTGATCAATGAAAT

CCAGAAATTGCAGGAAAAGTATAACGCACTGATAGTGATGGAGAACCTCAATTAT

GGGTTTAAGAACTCGCGTATCAAAGTGGAAAAGCAGGTCTACCAGAAATTCGAGA

CCGCCCTGATTAAAAAGTTTAATTACATCATTGACAAGAAAGATCCTGAAACCTA

CATTCATGGATACCAACTGACGAATCCAATCACTACACTCGATAAAATTGGTAAC

CAGAGCGGTATTGTGTTGTACATTCCGGCTTGGAATACAAGCAAGATTGATCCAG

TCACTGGTTTCGTTAACCTCCTGTATGCAGACGATTTGAAATACAAGAACCAGGA

GCAGGCTAAAAGCTTTATCCAGAAAATCGATAATATCTACTTCGAAAATGGTGAG

TTTAAATTTGATATAGATTTCAGCAAATGGAACAACCGCTACTCAATTAGCAAGA

CGAAATGGACACTGACAAGCTACGGAACCCGGATACAGACGTTCCGAAACCCCCA

GAAAAATAACAAGTGGGACAGCGCCGAGTATGACCTGACCGAAGAGTTTAAATTA

ATCCTGAACATCGATGGTACTCTGAAATCTCAGGATGTGGAAACCTATAAGAAAT

TCATGTCTTTATTCAAGCTGATGTTGCAGCTGCGAAACTCCGTTACTGGAACAGA

CATTGACTACATGATTAGCCCTGTGACAGATAAAACTGGAACCCACTTTGATTCA

CGGGAGAATATCAAGAACCTGCCCGCCGATGCTGATGCGAACGGAGCTTACAACA

TTGCTAGGAAGGGCATCATGGCAATCGAGAATATTATGAACGGCATTAGCGACCC

TCTGAAGATCAGTAATGAGGACTACCTGAAGTACATTCAGAACCAACAAGAGTAA

SEQ
ATGACCCAGTTTGAGGGTTTCACCAATCTTTATCAGGTGTCAAAAACACTCAGAT

ID
TTGAGCTCATCCCACAGGGTAAAACTTTAAAGCATATTCAAGAGCAGGGCTTTAT

NO:
AGAGGAAGACAAAGCCAGAAACGACCATTATAAGGAACTAAAACCGATCATTGAC

158
CGCATCTACAAAACCTATGCCGACCAATGCCTTCAGCTCGTCCAACTCGATTGGG

AGAATCTGAGCGCCGCTATTGACAGCTACAGGAAGGAGAAGACCGAGGAGACTAG

AAACGCCCTGATCGAGGAGCAGGCGACCTATAGAAACGCTATTCACGATTATTTT

ATCGGCCGCACCGACAATTTGACAGATGCCATCAACAAGCGGCACGCCGAAATTT

ATAAGGGGTTATTTAAGGCCGAGCTGTTCAATGGAAAAGTACTGAAACAGCTGGG

CACCGTAACAACCACCGAACACGAGAATGCTCTGTTGAGGTCCTTCGACAAGTTT

ACTACCTACTTTAGCGGCTTCTACGAAAACCGTAAAAACGTGTTTTCCGCGGAGG

ATATTTCAACAGCCATTCCTCATAGGATCGTGCAGGATAATTTCCCCAAGTTTAA

GGAGAACTGCCATATCTTTACCAGACTTATCACTGCTGTGCCAAGTTTACGAGAA

CACTTCGAGAATGTTAAGAAGGCTATAGGCATATTCGTTTCCACCTCCATCGAAG

AAGTATTCAGTTTTCCATTCTACAATCAGTTACTCACGCAGACCCAGATAGATCT

CTACAATCAGCTGCTCGGAGGCATTTCTAGAGAAGCAGGCACGGAAAAGATCAAG

GGCTTAAATGAAGTACTCAATCTTGCAATTCAGAAGAACGATGAGACAGCACACA

TTATTGCATCTCTCCCTCACAGATTCATTCCCCTGTTCAAACAGATCCTGTCCGA

TCGCAACACACTAAGCTTTATACTTGAGGAGTTTAAGTCAGATGAGGAAGTGATC

CAGAGCTTCTGTAAGTATAAGACTTTGCTCCGTAATGAAAACGTGCTTGAGACAG

CAGAGGCTCTCTTTAACGAGTTGAATTCCATCGACCTGACACACATTTTTATCAG

CCATAAAAAGCTGGAAACGATTAGCTCTGCCTTGTGCGACCACTGGGACACCCTG

CGTAACGCCCTCTATGAAAGGCGCATTTCCGAGCTCACCGGGAAGATCACAAAAA

GTGCCAAGGAAAAAGTCCAGAGGTCCCTTAAACATGAAGACATCAACCTACAAGA

GATCATCTCTGCGGCTGGGAAAGAGCTGTCAGAAGCATTTAAACAGAAGACTTCC

GAGATCCTGAGCCACGCACACGCCGCATTAGACCAGCCCCTGCCTACAACTCTTA

AAAAACAGGAGGAGAAGGAGATTTTAAAGAGCCAGCTGGACTCATTACTCGGCCT

GTATCATCTCCTGGACTGGTTCGCCGTGGACGAATCCAACGAGGTGGACCCAGAA

TTTAGCGCCAGGCTGACAGGAATTAAACTGGAAATGGAGCCAAGTTTGAGCTTTT

ACAACAAGGCTCGGAACTATGCCACTAAAAAGCCCTACAGCGTGGAAAAGTTCAA

GCTGAATTTTCAGATGCCGACCCTGGCTTCCGGGTGGGATGTTAATAAGGAAAAG

AATAATGGGGCTATACTGTTCGTCAAAAATGGTCTCTACTACCTGGGAATCATGC

CCAAACAGAAGGGCAGGTACAAAGCCCTTTCGTTTGAGCCGACCGAAAAAACCAG

CGAAGGCTTTGATAAGATGTATTACGACTATTTCCCAGATGCAGCCAAGATGATC

CCAAAATGTAGCACTCAGTTGAAGGCGGTAACCGCTCACTTTCAGACACACACCA

CTCCTATCTTGCTCTCCAACAACTTTATTGAGCCGCTGGAGATCACGAAGGAAAT

CTACGACCTTAACAACCCAGAGAAGGAACCCAAGAAATTCCAAACAGCTTATGCT

AAGAAGACTGGGGATCAAAAGGGCTATCGAGAGGCTTTGTGTAAGTGGATTGACT

TTACACGGGATTTCCTGAGTAAGTATACCAAGACCACATCTATTGACCTGTCCTC

ACTGAGACCTTCCTCACAATATAAGGATCTCGGAGAGTATTATGCCGAACTCAAC

CCTCTACTCTATCACATCTCTTTCCAGAGGATCGCCGAAAAGGAAATTATGGACG

CCGTCGAGACAGGCAAGCTGTACCTCTTCCAGATTTACAACAAGGATTTCGCAAA

GGGCCACCACGGAAAACCCAATTTGCACACTTTGTACTGGACAGGGCTCTTCTCT

CCCGAAAATTTGGCCAAAACTTCAATAAAACTGAACGGGCAAGCCGAGCTGTTCT

ATCGGCCCAAGTCACGTATGAAGCGGATGGCCCACCGGCTGGGCGAGAAGATGCT

CAACAAGAAACTGAAGGATCAGAAGACGCCCATACCAGACACTCTTTACCAAGAG

CTGTATGACTACGTGAATCACAGACTGAGTCACGACCTGTCTGATGAAGCCCGGG

CTCTTCTTCCAAATGTGATTACCAAAGAAGTTTCCCACGAAATTATCAAGGACCG

GCGCTTCACCTCTGACAAATTCTTTTTCCACGTCCCAATCACCCTCAACTACCAG

GCAGCCAATTCCCCTTCAAAGTTTAACCAGCGTGTGAATGCCTACCTGAAAGAGC

ATCCGGAGACCCCCATCATAGGGATAGACAGAGGAGAGCGGAATCTTATCTACAT

TACTGTGATTGACAGCACAGGTAAGATCTTGGAGCAGAGATCTTTAAATACAATC

CAGCAGTTTGACTACCAGAAGAAACTGGATAACCGAGAGAAGGAAAGGGTTGCTG

CAAGACAGGCCTGGTCAGTGGTCGGCACCATCAAAGACCTGAAGCAGGGCTACTT

ATCCCAAGTAATTCACGAAATTGTCGATCTTATGATTCATTATCAAGCCGTTGTT

GTGCTGGAGAACCTGAATTTTGGCTTCAAAAGCAAACGAACAGGTATCGCCGAGA

AAGCCGTGTATCAGCAGTTCGAAAAGATGCTCATAGACAAGCTGAACTGCTTAGT

GCTGAAGGATTATCCTGCTGAGAAGGTCGGCGGCGTACTTAACCCATACCAGCTG

ACCGATCAGTTCACTAGTTTCGCCAAGATGGGAACGCAAAGTGGCTTCCTTTTCT

ACGTGCCCGCTCCCTACACGAGTAAGATCGACCCTCTGACCGGCTTCGTCGACCC

ATTCGTCTGGAAGACCATCAAGAATCACGAATCACGGAAACACTTCTTAGAGGGG

TTTGACTTCCTGCACTACGACGTGAAGACAGGGGACTTCATCTTACACTTTAAGA

TGAATCGAAACCTCTCCTTCCAGCGGGGCCTGCCTGGTTTCATGCCCGCATGGGA

CATCGTGTTTGAGAAAAACGAGACACAGTTTGACGCTAAGGGAACCCCCTTTATT

GCGGGGAAGCGGATTGTCCCAGTCATCGAAAACCATCGGTTCACCGGGCGATACC

GGGATCTGTACCCGGCCAACGAGCTCATCGCGCTGCTGGAGGAGAAGGGTATTGT

GTTTAGGGATGGATCCAACATTCTGCCTAAGTTGCTGGAAAATGATGATTCGCAC

GCCATTGATACCATGGTTGCACTGATTAGATCCGTACTGCAGATGAGGAATAGCA

ATGCTGCAACCGGGGAGGATTATATTAATTCCCCAGTGCGAGATCTGAATGGTGT

CTGTTTTGACTCGCGCTTTCAGAATCCAGAATGGCCAATGGATGCAGACGCTAAC

GGGGCGTACCACATTGCTCTGAAAGGCCAGCTACTCCTGAACCACCTCAAGGAGA

GCAAAGATCTGAAGCTGCAGAACGGCATTTCCAACCAAGACTGGCTCGCCTACAT

ACAAGAACTGCGCAATTAA

SEQ
ATGGCTGTCAAATCCATCAAGGTTAAATTACGGCTTGATGACATGCCCGAGATCC

ID
GCGCCGGGCTCTGGAAACTCCATAAAGAAGTGAATGCTGGCGTTAGATACTACAC

NO:
AGAATGGCTCTCCCTGCTGCGCCAGGAAAATTTGTACCGCCGGTCACCTAATGGA

159
GATGGAGAGCAGGAATGCGATAAAACAGCAGAAGAGTGCAAAGCCGAATTGCTGG

AGCGACTGCGGGCACGGCAGGTTGAGAATGGACACCGAGGTCCGGCGGGATCGGA

CGACGAGCTGCTCCAGCTCGCCAGACAATTATATGAACTGCTGGTGCCTCAGGCT

ATTGGGGCAAAGGGTGACGCACAGCAGATTGCTAGAAAATTTCTGTCTCCCCTCG

CCGACAAAGACGCTGTCGGCGGCCTTGGGATAGCCAAAGCCGGCAACAAACCCCG

ATGGGTGCGCATGAGGGAGGCTGGTGAGCCTGGCTGGGAGGAAGAAAAGGAAAAG

GCCGAAACCAGAAAGTCCGCCGACAGGACCGCGGACGTACTCCGAGCATTGGCCG

ATTTTGGGCTGAAGCCCTTAATGCGAGTCTACACCGATAGTGAAATGTCTAGCGT

GGAGTGGAAGCCATTACGCAAAGGGCAGGCAGTGCGGACGTGGGACCGTGACATG

TTCCAGCAAGCCATCGAGCGAATGATGAGCTGGGAGAGCTGGAACCAGAGAGTGG

GGCAGGAGTATGCCAAGCTGGTCGAGCAGAAAAACCGGTTTGAGCAAAAAAATTT

TGTAGGTCAGGAACACCTGGTGCATCTCGTTAACCAGCTCCAGCAAGATATGAAG

GAAGCTTCGCCTGGATTAGAGAGCAAAGAGCAGACTGCACACTATGTAACCGGAA

GAGCACTGAGGGGCAGTGACAAAGTGTTCGAAAAATGGGGAAAACTGGCTCCCGA

TGCCCCCTTTGACCTGTACGACGCAGAAATAAAAAACGTGCAGCGGCGAAACACC

AGGCGATTTGGTAGCCATGATCTGTTCGCCAAATTGGCAGAGCCGGAATATCAGG

CTCTTTGGCGAGAAGACGCATCATTTCTCACTAGGTACGCGGTCTATAACTCCAT

TTTGAGGAAATTGAACCACGCAAAAATGTTTGCCACCTTCACGTTGCCTGACGCC

ACCGCTCATCCCATTTGGACACGGTTTGATAAGCTGGGCGGCAATCTGCATCAGT

ATACATTCCTGTTTAACGAGTTTGGAGAGCGAAGACATGCGATACGATTCCACAA

GCTACTGAAGGTCGAAAATGGCGTGGCACGTGAGGTGGACGATGTCACCGTGCCC

ATCAGCATGAGCGAACAGCTGGATAATTTGTTGCCGCGGGACCCAAATGAACCTA

TAGCCCTTTATTTTAGGGACTACGGGGCGGAGCAACATTTCACTGGGGAGTTTGG

CGGCGCAAAAATTCAGTGCCGACGCGACCAGCTCGCCCACATGCATAGAAGACGC

GGGGCCCGGGACGTATACCTTAACGTCTCTGTGAGGGTGCAGTCCCAGTCAGAGG

CAAGAGGGGAACGCAGACCACCTTACGCAGCAGTATTCAGGCTGGTAGGCGATAA

CCACCGGGCGTTTGTACACTTTGATAAACTTTCTGACTACCTGGCCGAACACCCG

GATGACGGCAAATTAGGATCGGAGGGGCTGCTTAGCGGCCTGCGTGTGATGAGCG

TCGATCTGGGGCTACGGACCTCTGCTTCCATCTCTGTGTTCCGTGTGGCCCGAAA

GGACGAGTTGAAACCTAATTCGAAGGGCCGTGTACCATTCTTTTTCCCTATTAAG

GGAAATGATAATCTCGTCGCGGTGCACGAGCGTTCCCAACTGCTGAAACTGCCTG

GCGAGACCGAGTCCAAAGATCTCAGAGCAATCCGGGAGGAGCGACAACGTACACT

TAGGCAACTCCGCACCCAGCTGGCCTATCTGCGCTTGCTGGTGCGGTGCGGCTCC

GAGGATGTAGGGAGAAGAGAGCGAAGCTGGGCAAAGCTGATAGAGCAACCAGTTG

ACGCCGCGAATCACATGACCCCCGACTGGCGCGAAGCGTTTGAAAATGAGCTGCA

GAAGTTGAAATCTCTGCATGGGATTTGCTCAGATAAGGAGTGGATGGACGCCGTA

TACGAGTCTGTTCGCCGGGTATGGCGGCACATGGGGAAGCAGGTGAGAGATTGGA

GAAAGGACGTTCGCTCTGGGGAACGGCCGAAAATTCGGGGATACGCAAAGGATGT

CGTGGGCGGCAATAGCATTGAGCAGATCGAGTACCTGGAAAGGCAATACAAATTT

CTGAAATCTTGGTCTTTCTTTGGGAAGGTAAGCGGACAAGTTATCAGAGCCGAAA

AGGGATCTCGCTTTGCTATCACATTGAGGGAACACATTGATCACGCCAAAGAAGA

CAGGTTGAAAAAGTTGGCTGATCGCATTATCATGGAAGCACTCGGTTACGTCTAC

GCCCTTGATGAGCGCGGTAAAGGGAAGTGGGTAGCCAAGTATCCCCCATGTCAGC

TGATCCTGCTCGAGGAACTTTCTGAGTATCAGTTCAATAACGACCGTCCTCCCTC

CGAAAATAATCAGCTCATGCAATGGTCCCACCGGGGTGTGTTCCAAGAACTGATC

AATCAGGCTCAGGTGCACGACCTCCTCGTAGGCACTATGTATGCAGCCTTTAGCT

CCCGTTTTGACGCGCGCACAGGCGCCCCTGGAATACGATGTAGGCGAGTTCCCGC

ACGGTGCACTCAAGAACATAACCCGGAGCCTTTCCCATGGTGGCTCAATAAGTTT

GTTGTGGAGCATACCCTCGACGCTTGCCCATTGAGGGCGGATGACTTGATTCCCA

CAGGCGAGGGGGAGATCTTCGTGAGCCCATTTTCTGCCGAAGAAGGGGATTTCCA

CCAAATACATGCCGACTTGAATGCTGCCCAAAATCTGCAGCAAAGGCTGTGGTCA

GACTTCGACATCTCGCAAATCAGACTGCGGTGTGACTGGGGCGAAGTAGACGGCG

AGCTGGTGCTGATACCTAGACTGACGGGTAAGCGTACCGCCGATAGCTATAGTAA

TAAGGTTTTTTATACGAATACGGGGGTGACATATTACGAGCGTGAGAGAGGCAAG

AAGCGTCGGAAGGTGTTCGCGCAGGAGAAGCTGAGCGAAGAGGAGGCGGAGCTAC

TGGTAGAGGCAGATGAGGCAAGAGAAAAGTCCGTCGTCCTGATGCGGGATCCTAG

CGGGATTATTAACAGAGGTAATTGGACACGGCAGAAAGAATTCTGGAGCATGGTG

AATCAAAGAATCGAGGGTTACCTGGTGAAGCAAATTCGAAGCCGGGTGCCCCTTC

AAGACAGCGCATGTGAAAACACTGGGGACATCTAG

SEQ
ATGGCTACTCGGTCCTTCATCCTGAAAATCGAGCCAAATGAAGAGGTGAAAAAGG

ID
GCCTGTGGAAGACCCATGAGGTACTTAACCACGGCATAGCATACTATATGAATAT

NO:
CCTAAAACTTATACGGCAGGAGGCTATCTACGAGCATCACGAGCAAGATCCTAAA

160
AATCCAAAGAAGGTTAGTAAGGCTGAAATCCAGGCTGAATTGTGGGACTTCGTGC

TGAAGATGCAGAAATGCAACAGTTTCACGCATGAAGTTGATAAGGACGTCGTGTT

TAATATACTCCGGGAGCTGTACGAAGAACTGGTACCAAGCTCTGTGGAAAAGAAA

GGAGAGGCCAACCAGCTAAGTAATAAGTTCCTCTATCCTCTCGTGGACCCCAATT

CACAGAGCGGCAAAGGTACCGCATCTTCTGGGAGGAAACCACGCTGGTACAACTT

GAAGATCGCTGGCGATCCCAGCTGGGAGGAGGAAAAGAAGAAATGGGAAGAGGAT

AAAAAGAAAGACCCCCTGGCCAAAATCTTAGGCAAGCTCGCCGAGTACGGTCTGA

TTCCACTTTTCATCCCGTTCACAGATAGCAATGAGCCGATCGTCAAGGAGATTAA

GTGGATGGAAAAGAGCCGCAATCAGAGTGTGCGGAGGCTGGACAAAGACATGTTT

ATTCAGGCCCTGGAACGCTTCCTTAGCTGGGAAAGCTGGAACCTGAAGGTTAAGG

AAGAGTACGAAAAAGTCGAGAAGGAGCATAAGACTTTGGAGGAGCGCATCAAAGA

AGACATCCAGGCCTTTAAGTCTCTAGAACAGTATGAGAAAGAACGGCAGGAACAG

CTGCTGCGTGATACACTGAACACAAACGAATATCGCCTGAGCAAGAGGGGACTCA

GAGGCTGGAGAGAAATCATTCAAAAGTGGCTCAAAATGGATGAAAATGAGCCGTC

TGAAAAATACCTTGAAGTTTTCAAGGACTACCAGCGGAAGCACCCTAGAGAAGCC

GGCGACTATAGTGTTTACGAATTCTTGAGCAAGAAGGAGAATCATTTTATATGGA

GGAATCACCCGGAGTACCCATATCTGTACGCAACCTTCTGCGAAATCGACAAGAA

AAAAAAAGACGCCAAGCAACAGGCTACATTTACTCTGGCCGACCCTATCAATCAC

CCTCTATGGGTCCGGTTTGAGGAGCGCTCCGGAAGCAATCTGAATAAATATCGTA

TTCTGACTGAACAGTTACACACAGAGAAGCTCAAGAAGAAACTTACGGTGCAGCT

GGACCGCCTGATATACCCAACAGAGTCCGGAGGATGGGAAGAGAAAGGAAAGGTT

GACATCGTACTGCTTCCATCTCGTCAGTTTTACAACCAGATATTCCTGGACATCG

AGGAGAAGGGGAAACACGCCTTCACATACAAGGACGAGTCCATAAAGTTCCCACT

GAAGGGTACTTTAGGCGGTGCTAGGGTGCAGTTCGACCGCGATCACCTGAGACGG

TACCCCCACAAGGTGGAGAGCGGGAACGTGGGACGAATCTACTTTAATATGACAG

TGAACATTGAACCCACAGAGAGTCCAGTTAGTAAATCCCTGAAAATTCACCGTGA

CGACTTTCCGAAATTTGTGAATTTCAAGCCAAAGGAGCTTACGGAGTGGATCAAG

GATTCAAAGGGAAAGAAGCTGAAATCTGGTATCGAATCTCTCGAGATCGGTCTCC

GTGTCATGAGCATCGATCTGGGACAGCGCCAGGCAGCTGCCGCCAGTATATTCGA

GGTGGTAGACCAAAAGCCTGACATCGAGGGAAAGCTCTTCTTCCCAATCAAAGGC

ACAGAGCTGTATGCGGTGCACCGGGCGTCCTTTAATATAAAGCTGCCCGGTGAAA

CCCTGGTGAAGTCACGGGAGGTGCTTAGAAAAGCGCGAGAGGATAACCTCAAACT

GATGAACCAAAAACTGAACTTTCTGAGGAACGTCCTGCACTTTCAGCAGTTCGAA

GATATTACCGAACGCGAAAAGAGAGTAACCAAGTGGATATCTCGTCAAGAGAACA

GCGACGTCCCGTTAGTCTATCAGGACGAACTCATCCAAATACGGGAGTTGATGTA

TAAGCCCTACAAGGATTGGGTCGCCTTTCTTAAGCAGCTTCACAAACGCCTAGAG

GTCGAAATAGGTAAAGAGGTGAAACATTGGCGGAAGTCGCTCAGCGACGGGAGGA

AGGGACTTTATGGCATCTCTTTGAAGAACATTGACGAAATCGATAGAACCAGAAA

ATTTTTGTTGAGATGGTCCCTCCGACCCACCGAGCCTGGAGAGGTGAGGCGGTTA

GAACCAGGACAGAGGTTCGCTATCGATCAGCTGAATCACCTCAATGCTCTGAAGG

AGGACCGCCTCAAGAAAATGGCCAATACAATCATAATGCACGCCCTTGGCTACTG

CTACGACGTCCGAAAGAAGAAGTGGCAGGCCAAGAATCCCGCCTGTCAAATTATC

CTTTTTGAGGATCTTAGCAATTACAACCCCTATGAAGAGCGGTCCAGATTCGAAA

ATAGTAAGCTCATGAAGTGGAGCCGCAGGGAGATCCCGCGCCAAGTGGCCCTTCA

GGGGGAAATTTATGGGCTGCAGGTAGGCGAGGTCGGGGCCCAATTCTCCTCGCGC

TTTCATGCGAAAACTGGAAGTCCTGGAATCCGGTGCTCAGTGGTGACAAAGGAGA

AGTTGCAAGACAATCGGTTTTTTAAAAACTTACAGCGGGAGGGAAGGCTGACCCT

GGATAAGATAGCCGTACTTAAGGAAGGAGATCTGTACCCTGACAAAGGCGGTGAA

AAGTTCATTAGCTTGAGCAAGGACCGAAAACTTGTGACCACCCACGCTGACATCA

ATGCGGCACAGAACCTGCAGAAGAGATTTTGGACTCGCACCCACGGATTCTACAA

AGTTTACTGCAAAGCATATCAAGTAGACGGACAGACCGTATACATCCCCGAGTCC

AAAGATCAGAAGCAGAAAATTATTGAAGAGTTTGGGGAAGGGTACTTTATCCTGA

AGGATGGTGTCTACGAATGGGGCAACGCTGGTAAACTTAAAATTAAGAAGGGCAG

CTCTAAACAGTCCTCCAGCGAGTTAGTTGATTCTGATATTCTGAAAGACAGTTTC

GACCTGGCCAGCGAACTTAAAGGGGAAAAATTAATGCTGTACCGGGACCCCAGCG

GAAACGTCTTTCCATCCGATAAGTGGATGGCCGCTGGAGTGTTCTTTGGCAAGTT

AGAGAGGATTCTCATAAGTAAGCTGACCAACCAATACTCAATCTCCACAATCGAG

GATGACTCATCCAAGCAGTCTATGTGA

SEQ
ATGCCTACACGCACTATCAACCTGAAACTGGTTCTTGGCAAGAATCCAGAGAATG

ID
CTACCCTTCGTCGGGCACTATTTTCAACGCATAGACTGGTGAATCAGGCTACCAA

NO:
ACGGATTGAAGAGTTCCTCTTGCTTTGTCGGGGGGAAGCATATAGGACGGTGGAT

161
AATGAGGGGAAAGAGGCTGAAATTCCGAGACACGCCGTGCAGGAGGAAGCTCTTG

CGTTTGCAAAGGCCGCTCAACGGCACAATGGTTGCATCTCTACTTATGAAGACCA

GGAAATCCTGGATGTGCTCCGGCAACTGTATGAAAGGCTGGTGCCTTCTGTGAAT

GAAAATAATGAAGCAGGGGACGCTCAAGCCGCAAACGCGTGGGTGTCGCCACTGA

TGTCCGCCGAGTCCGAGGGAGGGCTCAGCGTTTACGACAAGGTGCTGGACCCACC

CCCAGTGTGGATGAAACTCAAAGAGGAAAAAGCTCCGGGCTGGGAGGCTGCTTCC

CAGATCTGGATCCAGTCCGACGAAGGGCAGTCCCTTCTTAACAAGCCTGGTTCGC

CCCCGCGGTGGATTAGGAAACTGAGGTCAGGCCAGCCTTGGCAGGACGATTTTGT

TAGCGACCAGAAAAAGAAGCAGGACGAGCTGACAAAGGGGAATGCGCCACTGATC

AAACAATTAAAGGAAATGGGCTTATTGCCTCTTGTGAATCCCTTTTTTAGACATC

TGCTTGACCCGGAGGGGAAGGGGGTGTCACCTTGGGACAGACTCGCTGTTAGGGC

CGCTGTCGCTCATTTCATATCATGGGAATCATGGAACCACCGGACACGCGCCGAA

TACAATAGTTTGAAGCTGCGGAGGGATGAGTTCGAAGCAGCTTCCGACGAATTCA

AGGACGACTTCACGCTGCTTCGGCAGTACGAGGCTAAGAGGCACTCCACACTGAA

GAGTATAGCTTTAGCCGATGATTCAAACCCTTATAGGATCGGCGTACGCTCCCTC

CGCGCTTGGAACCGCGTCCGCGAGGAGTGGATCGACAAGGGAGCGACCGAGGAGC

AGCGGGTCACCATTCTCAGCAAGTTGCAGACCCAACTAAGGGGCAAATTTGGAGA

TCCTGACTTGTTCAACTGGCTGGCGCAGGACCGGCACGTGCACCTCTGGAGCCCT

AGAGATAGTGTTACCCCACTGGTTAGGATCAACGCTGTTGACAAAGTATTGCGAC

GGAGAAAACCGTACGCCTTGATGACTTTTGCCCACCCAAGATTCCACCCTCGGTG

GATACTTTACGAAGCCCCAGGGGGCAGCAATCTCCGCCAGTATGCACTGGATTGT

ACCGAAAATGCTCTGCACATTACACTGCCTCTGCTGGTTGACGATGCACATGGCA

CATGGATTGAGAAAAAAATTAGGGTTCCTCTTGCCCCCAGCGGCCAGATTCAGGA

CCTGACACTAGAAAAGCTCGAGAAGAAGAAAAATCGTCTCTACTACCGTTCTGGG

TTCCAGCAGTTTGCCGGCCTGGCCGGAGGTGCCGAGGTGCTTTTCCATCGACCAT

ACATGGAGCACGATGAGAGGAGCGAGGAGAGCTTATTAGAACGCCCTGGTGCTGT

TTGGTTCAAACTCACCTTGGACGTGGCAACCCAGGCCCCTCCAAACTGGTTGGAC

GGAAAGGGCCGCGTCCGAACGCCCCCCGAGGTTCACCACTTCAAGACAGCCCTCA

GTAACAAGTCTAAGCACACACGGACCCTCCAGCCCGGACTCAGAGTGTTATCCGT

GGATCTGGGAATGCGCACCTTCGCCTCTTGCTCCGTATTTGAGCTGATCGAGGGC

AAACCAGAGACTGGCAGAGCGTTCCCTGTGGCCGACGAACGTTCCATGGATTCAC

CAAACAAGCTGTGGGCCAAGCACGAAAGATCCTTTAAACTCACGCTCCCCGGCGA

AACCCCCAGTCGGAAAGAAGAGGAGGAACGGAGCATTGCAAGAGCCGAAATCTAT

GCGTTGAAAAGAGATATTCAGAGATTAAAAAGTCTTCTGCGCCTGGGGGAAGAGG

ATAACGATAATAGACGCGATGCACTTCTTGAGCAATTTTTCAAGGGCTGGGGCGA

GGAAGACGTGGTTCCAGGTCAGGCCTTTCCCCGGAGTCTGTTCCAGGGGCTGGGG

GCCGCCCCATTCAGATCCACCCCTGAGTTGTGGAGACAACACTGTCAAACCTATT

ATGATAAAGCAGAGGCGTGCCTGGCTAAACACATCAGCGATTGGCGCAAGAGAAC

CAGGCCTAGGCCTACCTCACGTGAGATGTGGTACAAGACACGCTCTTATCACGGC

GGAAAGTCAATCTGGATGCTGGAATACCTCGACGCTGTGAGGAAACTGCTCTTAT

CCTGGAGCCTCAGAGGCCGGACCTACGGGGCTATCAACAGACAGGACACAGCAAG

GTTCGGGAGCTTAGCCAGCCGGCTCCTTCACCACATTAACTCACTCAAAGAGGAT

CGAATAAAGACCGGAGCCGACTCGATCGTGCAGGCAGCCCGAGGGTACATCCCCC

TGCCTCATGGGAAGGGCTGGGAGCAGCGATATGAACCCTGCCAGCTGATCTTGTT

TGAGGACCTTGCCCGTTATAGATTTCGCGTTGATAGACCTCGCCGTGAGAATTCT

CAGCTGATGCAGTGGAACCACAGAGCGATCGTGGCTGAGACCACTATGCAGGCCG

AGCTGTATGGACAGATCGTGGAGAACACCGCCGCAGGGTTCAGTTCTCGGTTTCA

TGCTGCCACCGGAGCTCCCGGCGTCCGGTGCCGCTTCCTCTTAGAGCGTGATTTT

GACAATGACCTCCCAAAGCCCTATCTGCTGAGGGAACTGAGCTGGATGCTGGGGA

ACACAAAAGTAGAATCGGAGGAGGAGAAGCTACGGCTCCTCTCCGAAAAGATACG

TCCAGGCTCTCTGGTACCATGGGACGGAGGAGAGCAGTTCGCGACACTGCATCCT

AAGAGACAGACGTTATGTGTGATTCACGCCGATATGAACGCCGCTCAGAATCTGC

AGCGAAGATTCTTTGGCCGCTGCGGCGAAGCCTTCAGGCTGGTATGTCAGCCCCA

CGGGGATGATGTGCTGCGGCTGGCCTCAACCCCTGGGGCTAGACTCTTGGGGGCA

CTCCAGCAGCTGGAAAATGGCCAAGGGGCTTTCGAACTCGTTCGGGACATGGGCA

GCACAAGCCAGATGAACAGATTCGTCATGAAGAGCCTGGGAAAGAAAAAGATCAA

ACCCTTACAGGACAATAATGGCGACGACGAACTGGAGGACGTGTTGTCCGTGCTG

CCAGAGGAAGACGACACAGGCCGCATCACTGTCTTCCGCGACTCAAGTGGGATAT

TCTTTCCTTGCAACGTGTGGATTCCGGCCAAACAGTTCTGGCCTGCCGTCAGAGC

CATGATTTGGAAAGTGATGGCTAGTCATTCATTGGGATGA

SEQ
ATGACAAAGCTGAGGCACAGACAAAAGAAGCTTACACACGACTGGGCAGGGAGCA

ID
AGAAACGTGAGGTCCTTGGGTCAAATGGAAAACTGCAGAACCCCTTGCTCATGCC

NO:
TGTAAAGAAGGGGCAGGTAACAGAATTTAGAAAAGCATTCTCCGCGTACGCTCGG

162
GCAACTAAGGGGGAAATGACCGATGGACGGAAGAACATGTTCACCCATTCTTTCG

AGCCATTCAAAACAAAGCCGTCATTGCACCAATGCGAGCTGGCCGATAAGGCTTA

CCAGTCTTTGCATAGTTACCTCCCCGGTTCCCTGGCCCATTTCTTGCTTTCCGCA

CACGCACTGGGCTTTCGTATTTTCTCTAAATCTGGGGAGGCAACTGCCTTCCAGG

CCAGCTCAAAAATCGAGGCCTATGAGTCCAAGCTCGCTTCGGAGCTAGCCTGTGT

CGATTTGAGTATCCAGAATTTGACGATTAGTACTCTTTTCAACGCTCTCACAACT

TCAGTTCGGGGCAAGGGGGAGGAAACTTCAGCAGATCCCCTTATCGCACGGTTCT

ACACTCTCCTGACGGGCAAGCCCCTGAGCCGAGACACACAGGGCCCAGAACGGGA

CTTGGCAGAGGTCATCTCCAGAAAGATCGCCTCGTCCTTCGGCACATGGAAGGAA

ATGACTGCCAACCCTCTGCAGAGCCTCCAGTTCTTCGAAGAAGAGCTTCATGCAC

TAGATGCCAACGTGTCTTTATCTCCAGCTTTTGATGTGTTAATCAAGATGAATGA

TCTCCAAGGTGATCTGAAGAACCGTACTATAGTGTTCGACCCAGATGCACCCGTG

TTCGAGTACAACGCTGAGGATCCAGCCGATATCATCATAAAGCTGACAGCTCGGT

ATGCGAAGGAGGCCGTCATCAAGAATCAGAACGTGGGCAATTATGTGAAAAACGC

CATTACCACCACTAATGCCAATGGGCTGGGGTGGCTCCTCAATAAAGGGCTTTCA

CTACTGCCAGTTTCTACTGACGATGAGCTGCTCGAATTCATTGGGGTGGAGAGAA

GCCATCCCAGCTGTCACGCGCTGATAGAGCTGATTGCCCAGCTAGAGGCGCCGGA

ACTGTTTGAGAAGAATGTGTTTAGTGACACCCGTTCCGAGGTTCAGGGTATGATC

GACAGTGCAGTGTCGAACCACATTGCTCGGCTGTCCAGCAGCCGAAACTCCCTGA

GCATGGACAGCGAGGAATTGGAACGCTTGATTAAATCTTTCCAGATTCATACTCC

CCATTGTTCTCTGTTCATAGGCGCTCAGTCCTTATCTCAGCAGCTGGAGAGCTTA

CCTGAGGCGCTGCAGTCCGGAGTGAACAGCGCTGATATCTTATTAGGCAGCACAC

AGTATATGCTGACCAACTCTCTCGTTGAAGAGTCAATTGCAACATATCAAAGGAC

ATTAAATAGGATCAATTACCTGAGTGGGGTGGCTGGGCAGATTAACGGTGCTATC

AAAAGAAAGGCAATCGACGGCGAAAAAATACACCTGCCTGCCGCCTGGAGTGAGC

TCATCTCCTTACCTTTCATTGGACAGCCGGTGATTGATGTGGAGAGCGACCTGGC

ACACTTAAAAAACCAGTACCAGACCCTGTCCAATGAATTTGACACCCTCATTTCG

GCCCTGCAGAAGAACTTCGATTTGAATTTCAACAAAGCACTCCTTAACCGCACGC

AGCATTTCGAGGCAATGTGCCGGAGCACAAAAAAAAATGCTTTATCTAAGCCCGA

GATCGTGTCCTACAGAGATCTGCTGGCGCGGCTGACCAGTTGCCTTTATCGAGGC

TCGCTGGTTCTCAGAAGGGCGGGAATCGAAGTTCTGAAAAAGCACAAAATCTTTG

AGTCGAATAGTGAGCTGAGAGAACACGTCCACGAGCGAAAGCACTTCGTGTTCGT

TAGTCCATTGGACAGAAAGGCAAAAAAACTGTTGCGCCTGACCGATTCCCGCCCT

GACTTGCTCCATGTGATCGATGAGATCCTGCAACATGACAATCTGGAGAATAAGG

ACAGAGAGTCCCTTTGGCTGGTCCGGTCTGGGTACCTCCTTGCTGGTCTGCCGGA

CCAGCTGAGTTCTTCGTTTATCAATCTCCCCATAATCACGCAAAAGGGCGATCGC

CGGCTGATTGACCTGATTCAGTATGACCAGATCAATCGCGATGCTTTCGTAATGT

TGGTGACAAGTGCTTTCAAAAGCAATCTCTCTGGGTTGCAGTACCGCGCTAACAA

GCAGTCTTTCGTGGTCACCCGCACCCTGTCTCCTTACCTGGGTAGTAAGCTCGTA

TACGTCCCTAAAGACAAAGATTGGCTGGTCCCATCCCAGATGTTTGAGGGAAGAT

TCGCCGATATTCTGCAGAGTGACTACATGGTCTGGAAGGATGCCGGACGCCTGTG

CGTGATCGACACTGCCAAACATCTCTCTAACATTAAAAAAAGCGTGTTTAGTAGC

GAAGAAGTCCTTGCTTTTCTTCGAGAGCTGCCTCACCGGACCTTCATCCAGACCG

AGGTACGGGGGTTAGGAGTGAACGTCGATGGAATCGCATTTAATAACGGGGATAT

CCCGAGCTTGAAGACATTCTCGAATTGTGTGCAGGTGAAGGTGAGTAGGACTAAT

ACTAGTCTCGTGCAGACTCTAAACAGGTGGTTCGAGGGTGGCAAAGTGTCACCTC

CCTCTATTCAGTTCGAAAGAGCTTACTACAAAAAAGACGATCAGATTCACGAGGA

CGCAGCCAAGAGAAAGATACGCTTCCAGATGCCAGCAACGGAATTAGTGCACGCC

AGCGATGACGCTGGTTGGACCCCCAGCTACCTGCTGGGCATCGACCCCGGTGAGT

ACGGAATGGGTCTCAGTTTGGTGTCCATCAACAATGGAGAGGTCCTGGATTCTGG

ATTCATCCACATTAATTCCCTGATCAATTTCGCGTCCAAAAAAAGCAATCACCAG

ACCAAAGTAGTCCCCCGCCAGCAGTACAAGTCCCCCTACGCGAATTATCTCGAGC

AGTCAAAGGATTCAGCAGCAGGGGATATAGCTCACATTCTGGATCGGCTAATCTA

CAAATTGAACGCCTTGCCTGTGTTCGAGGCGCTGTCTGGCAACAGTCAGAGTGCT

GCTGATCAGGTATGGACCAAAGTTCTATCCTTCTATACATGGGGAGACAACGACG

CACAGAACAGTATACGGAAGCAGCACTGGTTCGGTGCCTCACACTGGGATATTAA

GGGGATGCTGCGCCAACCCCCAACCGAAAAAAAACCCAAACCATATATAGCCTTT

CCCGGGAGTCAAGTGTCATCCTATGGAAATAGTCAAAGGTGTAGTTGTTGCGGCC

GCAATCCCATTGAGCAGTTGCGTGAGATGGCAAAGGACACGAGTATCAAGGAGCT

GAAAATCCGAAATAGTGAGATCCAACTATTCGATGGTACAATCAAGCTGTTTAAC

CCCGACCCTTCCACCGTCATCGAGAGGCGGCGGCATAACCTAGGACCCTCACGCA

TTCCTGTGGCAGACCGAACTTTCAAGAATATTAGCCCTTCTTCGTTAGAGTTCAA

GGAGCTCATTACTATCGTTTCTCGAAGCATCCGCCATAGCCCCGAATTTATTGCT

AAGAAACGGGGTATCGGGTCTGAGTACTTTTGTGCTTATTCTGACTGCAACTCCT

CACTGAACTCAGAGGCCAATGCCGCGGCCAATGTGGCACAGAAGTTTCAGAAGCA

ACTCTTTTTCGAACTCTGA

SEQ
ATGAAACGTATTCTGAACTCTCTGAAAGTCGCCGCACTGAGGCTGCTGTTTCGAG

ID
GAAAGGGCTCAGAGCTGGTGAAGACCGTCAAGTACCCTCTGGTTTCGCCCGTCCA

NO:
GGGTGCTGTGGAAGAACTCGCCGAAGCAATACGCCACGACAACCTACATTTATTT

163
GGGCAGAAGGAAATCGTAGATCTGATGGAGAAGGACGAGGGCACCCAGGTCTACT

CGGTGGTGGACTTTTGGCTCGACACACTCCGTCTAGGGATGTTCTTCAGTCCAAG

TGCTAATGCCCTTAAGATCACTCTGGGGAAGTTTAACAGCGACCAAGTTTCCCCT

TTCAGGAAGGTTCTGGAGCAGTCCCCTTTCTTTCTCGCGGGTAGACTCAAAGTGG

AGCCCGCTGAACGTATCCTCAGCGTGGAGATCCGCAAGATCGGTAAGAGGGAGAA

TAGAGTGGAGAACTACGCCGCAGATGTAGAGACTTGTTTTATCGGTCAGCTGTCT

AGTGATGAAAAGCAGTCTATCCAGAAGCTCGCTAACGATATCTGGGACTCTAAGG

ATCACGAAGAGCAAAGGATGCTTAAGGCGGATTTCTTTGCCATTCCCCTCATCAA

AGACCCAAAGGCAGTGACCGAGGAAGATCCCGAGAATGAAACCGCAGGCAAACAG

AAGCCTCTCGAATTATGTGTGTGCTTAGTGCCCGAGTTGTACACCCGCGGGTTCG

GTTCAATAGCGGACTTCCTGGTCCAGCGTCTGACACTATTAAGAGACAAAATGAG

CACAGACACAGCAGAAGACTGCCTTGAGTATGTCGGCATAGAGGAGGAGAAGGGT

AATGGGATGAACTCGCTGCTGGGGACGTTCCTCAAGAACCTGCAGGGAGACGGGT

TCGAACAGATCTTCCAATTTATGCTCGGCAGTTACGTGGGATGGCAAGGTAAGGA

AGACGTCCTACGCGAACGGCTTGATTTGCTAGCGGAGAAGGTTAAAAGACTGCCG

AAACCTAAGTTTGCCGGCGAGTGGTCCGGCCATCGGATGTTCCTGCATGGTCAAT

TGAAGAGCTGGTCCTCTAACTTTTTCCGCCTGTTTAACGAGACTAGGGAGCTCCT

CGAAAGCATAAAATCCGACATCCAACACGCGACCATGTTAATCAGCTACGTCGAA

GAGAAAGGGGGATACCACCCACAACTCTTGTCACAGTACAGGAAACTAATGGAGC

AGCTGCCAGCTCTCAGAACAAAGGTGTTAGATCCAGAGATAGAAATGACTCACAT

GAGCGAGGCGGTAAGGTCGTACATTATGATCCACAAGTCGGTAGCAGGATTTCTG

CCTGACTTACTCGAGTCCCTCGATAGGGACAAGGACAGGGAATTCCTGCTGAGTA

TATTTCCAAGGATCCCCAAAATTGACAAAAAAACTAAGGAAATCGTGGCCTGGGA

GCTCCCAGGCGAGCCCGAAGAAGGATACCTGTTCACTGCCAATAATCTTTTTCGC

AACTTTCTGGAGAATCCTAAACATGTTCCACGTTTCATGGCAGAAAGGATCCCGG

AAGATTGGACGCGCCTGCGGTCCGCTCCCGTATGGTTTGACGGCATGGTGAAACA

ATGGCAGAAAGTGGTAAACCAGCTGGTGGAGTCACCTGGAGCATTGTATCAGTTC

AATGAAAGCTTTCTCCGACAACGTTTACAGGCAATGCTGACAGTGTATAAGAGAG

ACCTGCAGACAGAGAAATTCCTTAAGTTGTTGGCTGATGTCTGCAGGCCTCTGGT

GGACTTCTTTGGGCTGGGGGGAAACGATATCATCTTCAAAAGCTGCCAGGACCCG

AGGAAACAATGGCAAACTGTCATTCCCTTGAGTGTCCCCGCTGATGTGTACACCG

CGTGTGAGGGGCTGGCAATCCGGCTTCGTGAGACATTGGGATTTGAGTGGAAGAA

CCTTAAGGGCCATGAAAGGGAGGACTTTCTAAGACTGCACCAGCTTTTAGGGAAT

CTGCTTTTCTGGATTCGAGATGCCAAACTGGTGGTGAAATTGGAAGATTGGATGA

ATAATCCCTGTGTTCAGGAGTACGTTGAGGCTCGTAAGGCCATTGATCTCCCACT

GGAGATCTTCGGCTTTGAGGTCCCCATCTTCCTGAACGGATATCTGTTTAGTGAA

CTGAGGCAGTTAGAACTGCTGCTCCGCCGTAAGTCGGTTATGACCAGCTATTCGG

TTAAGACAACTGGCAGTCCAAACAGGCTTTTCCAGTTAGTCTACCTGCCATTAAA

TCCTTCCGACCCTGAGAAAAAAAATTCTAATAACTTTCAGGAACGCCTGGACACC

CCCACTGGCTTATCACGTCGCTTCCTGGACCTTACTCTGGACGCCTTCGCCGGCA

AGTTGCTGACAGACCCCGTGACTCAAGAGCTTAAAACTATGGCTGGGTTCTACGA

TCACCTGTTTGGTTTCAAGCTCCCATGTAAGCTGGCAGCCATGTCTAACCACCCT

GGCTCTAGCAGCAAGATGGTCGTGTTGGCCAAACCTAAAAAAGGGGTTGCATCTA

ATATAGGATTCGAACCAATCCCTGATCCCGCGCACCCCGTATTCCGGGTGAGATC

ATCATGGCCAGAGCTGAAGTATCTGGAGGGGTTACTGTATCTTCCAGAAGACACT

CCACTGACAATAGAGCTCGCAGAGACAAGTGTTAGTTGTCAGAGCGTCAGTAGCG

TGGCATTCGATCTGAAAAATCTGACTACTATCCTTGGACGCGTGGGTGAGTTCCG

TGTGACCGCAGACCAGCCTTTTAAGTTGACCCCCATCATCCCTGAGAAGGAGGAG

TCCTTCATAGGAAAAACATATCTAGGCCTTGATGCCGGGGAACGCTCAGGCGTAG

GGTTCGCTATCGTCACAGTCGACGGGGATGGGTACGAGGTACAGCGCCTGGGGGT

GCATGAAGATACACAGCTGATGGCCCTACAGCAGGTGGCCTCTAAAAGCTTGAAG

GAGCCGGTGTTCCAGCCGCTCAGAAAGGGTACTTTTCGGCAGCAGGAACGTATTA

GAAAATCTCTCAGAGGATGTTATTGGAACTTCTATCACGCTCTGATGATTAAGTA

CCGCGCCAAGGTAGTGCACGAAGAGAGCGTGGGCAGTTCCGGCCTGGTTGGGCAG

TGGTTACGAGCATTCCAGAAGGACCTCAAGAAAGCCGATGTGTTGCCAAAAAAGG

GAGGCAAAAACGGAGTCGATAAGAAAAAGAGAGAGTCTTCTGCACAAGACACATT

GTGGGGAGGGGCTTTTAGCAAGAAGGAAGAACAGCAGATAGCTTTCGAAGTCCAA

GCTGCTGGTTCTAGCCAGTTCTGCCTGAAGTGCGGATGGTGGTTCCAACTCGGAA

TGCGTGAGGTTAATCGCGTGCAGGAATCCGGCGTCGTGCTGGATTGGAATCGGAG

TATTGTCACATTCCTGATTGAGAGCTCTGGCGAGAAAGTGTATGGGTTCTCCCCT

CAGCAACTCGAAAAGGGGTTCAGACCAGACATTGAAACCTTCAAGAAGATGGTTC

GGGATTTCATGCGCCCGCCTATGTTTGACCGGAAGGGTCGCCCAGCAGCTGCCTA

CGAAAGGTTTGTCTTGGGACGCCGGCATCGGCGGTATAGATTCGACAAGGTTTTT

GAAGAACGATTCGGACGATCCGCGCTATTCATTTGCCCGAGGGTTGGCTGTGGCA

ACTTTGACCACAGCAGCGAGCAGTCAGCCGTAGTGCTGGCTCTAATCGGATATAT

TGCCGACAAAGAGGGGATGAGCGGAAAAAAGCTAGTCTACGTGCGTCTGGCAGAA

CTAATGGCGGAATGGAAATTGAAGAAACTGGAGAGGAGTAGAGTTGAGGAGCAAA

GCTCCGCTCAGTGA

SEQ
ATGGCGGAGTCGAAGCAAATGCAGTGCAGGAAGTGTGGAGCCTCTATGAAGTACG

ID
AAGTGATCGGCCTCGGGAAGAAAAGCTGCAGATATATGTGTCCCGACTGCGGGAA

NO:
TCACACATCTGCAAGAAAGATTCAGAATAAGAAGAAAAGGGACAAGAAGTATGGA

164
TCTGCCAGTAAAGCACAAAGCCAACGAATCGCAGTTGCAGGGGCCTTATACCCGG

ATAAAAAGGTTCAGACCATCAAGACTTATAAGTATCCAGCCGACCTGAATGGTGA

GGTCCATGACTCAGGGGTGGCCGAAAAAATAGCCCAAGCAATCCAGGAGGATGAA

ATAGGGCTCCTCGGCCCCTCTTCCGAGTACGCCTGTTGGATCGCTAGCCAGAAAC

AGAGCGAGCCCTACAGTGTTGTAGACTTTTGGTTTGACGCTGTGTGCGCCGGAGG

CGTGTTCGCCTATTCTGGGGCTAGATTGCTGTCTACCGTCCTGCAGCTATCTGGG

GAGGAGAGCGTCCTACGCGCAGCCCTGGCATCCTCCCCTTTTGTCGACGATATCA

ATCTGGCACAGGCCGAAAAATTTCTGGCGGTGTCCAGGCGAACCGGCCAAGATAA

GCTGGGGAAGCGCATTGGAGAGTGCTTCGCAGAGGGCCGACTTGAGGCCCTAGGC

ATCAAGGACCGGATGCGTGAATTTGTCCAGGCTATCGATGTCGCTCAGACCGCTG

GGCAGCGTTTTGCCGCGAAACTGAAAATCTTTGGGATTTCTCAGATGCCCGAGGC

AAAGCAGTGGAACAATGACAGCGGACTCACCGTGTGCATCCTGCCCGACTATTAC

GTCCCAGAAGAAAATCGCGCAGATCAGTTGGTCGTCCTGCTAAGACGACTGAGAG

AGATAGCATACTGTATGGGGATCGAAGATGAGGCCGGTTTTGAACATCTTGGAAT

TGATCCTGGCGCACTATCAAATTTTTCCAATGGCAATCCTAAACGCGGATTTTTG

GGCCGCCTGCTGAACAATGATATTATTGCCTTAGCGAACAACATGTCCGCCATGA

CGCCTTACTGGGAGGGCAGGAAGGGAGAACTGATTGAAAGATTGGCTTGGCTGAA

GCACCGTGCAGAGGGGCTTTATCTGAAGGAACCGCATTTTGGAAATAGTTGGGCC

GACCATAGGTCTAGAATTTTTTCCAGAATAGCCGGGTGGCTTTCTGGGTGCGCTG

GGAAGCTAAAGATCGCCAAAGACCAGATCAGCGGAGTGCGTACTGATCTGTTCCT

TCTGAAGAGACTGCTGGATGCGGTCCCGCAGTCCGCCCCTTCTCCCGACTTCATA

GCCTCTATCTCTGCCTTGGATCGCTTCCTGGAGGCCGCAGAATCTAGTCAGGATC

CTGCCGAACAGGTGAGGGCCCTATACGCCTTTCATCTGAACGCACCCGCGGTGCG

AAGCATCGCCAACAAGGCAGTCCAGCGATCCGACAGCCAAGAATGGCTTATAAAG

GAACTGGACGCTGTGGACCACCTGGAGTTTAACAAGGCCTTTCCCTTCTTCTCTG

ATACGGGAAAGAAGAAAAAGAAAGGGGCTAACTCGAATGGCGCTCCGTCCGAGGA

GGAGTACACCGAGACTGAGAGCATCCAGCAGCCCGAGGACGCTGAGCAAGAGGTT

AATGGTCAGGAAGGCAACGGGGCCTCGAAGAACCAGAAGAAGTTTCAGAGAATCC

CCCGATTCTTCGGCGAGGGGAGTCGCAGCGAGTATCGCATCCTCACTGAAGCCCC

GCAGTACTTCGACATGTTCTGTAACAACATGCGGGCCATCTTTATGCAATTAGAA

TCCCAACCGCGTAAAGCTCCCAGGGATTTTAAGTGTTTCCTGCAGAATCGGCTGC

AGAAATTGTATAAGCAGACATTCCTGAACGCTCGATCCAACAAGTGCCGGGCATT

ACTAGAGTCCGTATTGATTAGTTGGGGAGAGTTTTACACCTACGGGGCTAACGAG

AAAAAATTTCGACTGCGTCATGAAGCTTCTGAGCGCTCCTCGGACCCAGATTACG

TGGTGCAACAGGCGCTGGAGATCGCTCGGAGGCTGTTTCTCTTCGGCTTTGAGTG

GAGGGACTGTAGCGCAGGTGAAAGAGTGGATCTGGTCGAAATACATAAGAAAGCC

ATATCTTTCCTGTTGGCCATCACTCAGGCTGAGGTGTCTGTGGGCAGCTATAACT

GGCTGGGCAATTCTACCGTGAGTCGGTACCTGTCCGTGGCAGGGACTGATACCCT

TTACGGCACCCAGCTGGAAGAATTCTTAAATGCAACCGTGTTATCTCAGATGCGG

GGGCTGGCTATCAGGTTATCATCTCAGGAACTGAAGGATGGATTTGACGTACAGC

TGGAGTCTAGTTGCCAGGATAATCTGCAACACTTGCTCGTGTACAGGGCTTCACG

AGACCTTGCCGCCTGCAAGCGCGCTACTTGTCCAGCTGAGTTGGATCCTAAGATT

CTGGTACTGCCCGTGGGGGCCTTTATCGCTAGCGTGATGAAAATGATTGAAAGAG

GGGATGAGCCTTTAGCTGGAGCTTATCTGAGACACAGACCCCATAGTTTCGGGTG

GCAGATCCGCGTTCGAGGTGTGGCAGAGGTGGGAATGGACCAAGGGACCGCCCTG

GCGTTCCAGAAACCGACCGAGAGCGAACCCTTCAAGATAAAGCCGTTTTCCGCTC

AATACGGCCCCGTTCTATGGCTGAACAGCTCCAGTTATAGCCAGAGCCAGTACCT

GGACGGGTTCCTATCACAGCCCAAGAACTGGAGTATGCGGGTGCTGCCACAGGCC

GGCTCAGTGCGGGTAGAACAGCGCGTCGCCTTGATTTGGAATCTCCAGGCCGGAA

AGATGAGGCTGGAACGGAGCGGAGCGCGGGCTTTCTTCATGCCCGTCCCATTCAG

TTTCCGCCCCAGTGGCAGCGGCGACGAGGCAGTCCTGGCTCCAAATAGGTACCTG

GGACTCTTTCCACACAGCGGCGGCATAGAGTACGCTGTGGTCGATGTTCTTGACT

CTGCCGGCTTCAAAATACTCGAGAGAGGAACAATAGCCGTCAATGGCTTCTCCCA

GAAACGAGGAGAAAGACAAGAGGAAGCCCATCGCGAAAAACAAAGACGCGGTATC

TCCGATATTGGGCGCAAGAAGCCAGTCCAGGCCGAAGTCGATGCGGCCAACGAGC

TCCATCGAAAATACACCGATGTTGCTACTCGGCTGGGGTGTCGAATTGTCGTTCA

ATGGGCACCCCAACCCAAACCAGGCACTGCGCCGACCGCTCAGACTGTGTACGCT

AGGGCCGTGAGGACTGAAGCACCAAGATCCGGCAATCAGGAAGATCACGCCAGGA

TGAAATCTTCCTGGGGATACACATGGGGTACGTATTGGGAAAAAAGGAAGCCCGA

GGACATCCTCGGCATTAGTACCCAGGTGTATTGGACAGGCGGGATCGGCGAGTCC

TGCCCGGCTGTCGCCGTCGCGCTATTGGGACACATCAGGGCCACCTCAACCCAGA

CTGAATGGGAGAAAGAGGAAGTCGTGTTTGGGCGATTGAAAAAGTTCTTCCCATC

CTGA

SEQ
ATGGAGAAGCGCATCAATAAAATTCGCAAGAAGCTGTCTGCCGATAACGCCACAA

ID
AACCAGTTAGTCGAAGCGGCCCAATGAAGACCCTGCTAGTTCGAGTGATGACTGA

NO:
TGATCTGAAGAAAAGGCTCGAAAAGCGACGCAAGAAGCCTGAGGTAATGCCTCAG

165
GTTATAAGTAACAATGCAGCAAACAATCTGCGGATGCTGCTTGACGATTACACAA

AGATGAAGGAAGCCATTCTCCAGGTGTATTGGCAGGAGTTCAAGGATGATCACGT

AGGCCTGATGTGTAAATTCGCGCAACCTGCAAGCAAGAAGATCGACCAAAACAAG

CTGAAACCCGAGATGGATGAAAAAGGCAATTTAACAACCGCCGGATTCGCTTGTT

CCCAGTGTGGGCAGCCACTGTTCGTGTACAAGTTAGAACAGGTGTCGGAAAAAGG

AAAGGCATACACTAACTACTTTGGACGGTGCAATGTTGCAGAACACGAAAAGCTG

ATACTGCTTGCCCAGCTTAAGCCCGAAAAAGACAGCGACGAAGCGGTGACCTACA

GCCTGGGAAAATTCGGGCAGCGGGCACTGGACTTCTATTCTATCCACGTTACCAA

GGAGAGCACCCACCCAGTGAAGCCGTTGGCCCAAATCGCTGGAAACCGGTACGCC

AGCGGACCAGTCGGCAAGGCCCTGTCCGATGCCTGTATGGGCACAATTGCTTCTT

TCCTGTCCAAGTACCAGGACATCATAATCGAGCACCAAAAAGTTGTGAAAGGGAA

TCAGAAACGCCTGGAATCCCTTCGAGAACTGGCCGGCAAGGAGAACCTTGAGTAC

CCGTCCGTGACCCTGCCTCCACAGCCACATACCAAAGAGGGCGTAGACGCGTATA

ATGAGGTCATTGCCCGCGTTCGCATGTGGGTTAATTTAAACCTGTGGCAGAAATT

AAAACTAAGCCGAGATGATGCTAAACCGTTACTGAGATTGAAGGGATTCCCTAGC

TTTCCTGTGGTGGAGAGAAGGGAAAACGAGGTTGATTGGTGGAATACTATTAATG

AGGTGAAAAAGCTTATTGACGCCAAGAGGGATATGGGCAGGGTGTTCTGGAGCGG

GGTGACTGCCGAAAAGAGAAATACCATCCTCGAGGGATACAATTACCTCCCCAAC

GAGAATGATCATAAGAAAAGAGAGGGGAGCTTAGAGAATCCAAAGAAACCTGCAA

AGAGGCAATTCGGTGATCTCCTGCTCTACCTCGAGAAGAAATACGCGGGGGACTG

GGGAAAAGTTTTTGACGAAGCCTGGGAGCGCATTGACAAGAAGATCGCCGGGCTG

ACGTCTCACATTGAACGGGAAGAGGCACGGAATGCAGAGGACGCCCAGTCTAAGG

CCGTGCTGACTGACTGGCTGCGCGCAAAGGCCTCCTTCGTGCTCGAACGTCTGAA

GGAAATGGATGAGAAAGAGTTTTACGCGTGTGAAATACAGCTGCAGAAGTGGTAC

GGCGATCTAAGGGGAAATCCCTTCGCAGTGGAAGCCGAGAATAGGGTAGTTGACA

TCAGTGGGTTCTCCATCGGCAGTGATGGACATTCTATCCAGTATAGAAACCTGCT

CGCCTGGAAGTACTTAGAGAACGGCAAGAGAGAGTTCTATCTGCTGATGAACTAC

GGGAAAAAAGGTAGAATTCGCTTTACAGATGGCACCGACATAAAGAAGTCCGGAA

AGTGGCAAGGCCTCTTATACGGAGGCGGCAAAGCAAAGGTGATAGACTTGACTTT

TGACCCTGACGACGAACAGCTGATAATCTTGCCGCTGGCCTTTGGCACAAGACAA

GGTAGGGAATTTATCTGGAATGATCTTCTTTCTCTCGAGACCGGACTCATCAAGC

TCGCAAACGGAAGGGTCATCGAGAAGACAATCTACAATAAAAAGATAGGCCGAGA

CGAGCCAGCCCTGTTTGTGGCTTTGACATTTGAGCGGAGAGAGGTCGTAGATCCC

AGCAACATCAAACCCGTGAACCTGATCGGTGTTGACAGGGGCGAGAACATCCCGG

CGGTTATCGCACTGACGGATCCAGAAGGATGTCCTCTGCCCGAGTTCAAAGATTC

ATCGGGAGGGCCAACCGACATTTTGAGGATAGGGGAGGGGTACAAGGAGAAGCAG

CGAGCTATCCAGGCGGCCAAAGAAGTGGAGCAACGAAGAGCTGGTGGTTATTCTC

GCAAGTTCGCTTCCAAAAGTCGTAACCTGGCTGACGATATGGTGCGCAATTCTGC

CCGTGACCTTTTCTACCACGCCGTTACACACGACGCCGTGTTAGTGTTTGAAAAT

CTTAGTCGAGGCTTCGGGCGACAGGGGAAGCGGACCTTTATGACCGAGAGACAGT

ATACAAAAATGGAGGATTGGCTGACCGCCAAACTGGCGTATGAAGGACTCACATC

CAAGACCTATCTCTCAAAAACTTTGGCCCAGTATACATCTAAGACGTGCAGTAAC

TGTGGCTTCACCATTACCACAGCTGACTACGATGGCATGCTGGTCCGCTTAAAAA

AGACATCTGACGGCTGGGCTACTACCCTCAACAATAAAGAGCTCAAAGCCGAAGG

ACAAATTACCTATTATAACAGGTATAAAAGACAGACTGTCGAGAAGGAGTTGAGC

GCGGAGCTGGACCGCCTATCAGAGGAGTCAGGGAACAACGATATCTCTAAGTGGA

CTAAGGGACGCCGAGACGAGGCGTTGTTCTTGCTGAAAAAGCGGTTCTCTCATCG

ACCCGTGCAGGAGCAGTTCGTGTGTCTGGACTGCGGCCACGAGGTTCATGCTGAT

GAGCAAGCTGCTCTAAATATTGCCCGTAGTTGGTTGTTCCTGAACAGCAATTCAA

CAGAGTTCAAGTCATACAAGAGCGGAAAGCAGCCGTTTGTGGGCGCATGGCAGGC

ATTTTACAAAAGACGCCTGAAGGAAGTGTGGAAGCCAAACGCC

SEQ
ATGAAAAGGATTAACAAAATCCGAAGGCGGCTTGTAAAGGATTCTAACACCAAAA

ID
AGGCTGGCAAGACGGGGCCCATGAAAACATTACTCGTTAGAGTTATGACCCCCGA

NO:
CCTCAGAGAGCGACTGGAAAATTTACGCAAGAAGCCAGAGAACATACCTCAGCCA

166
ATTAGTAATACCTCTCGGGCAAACCTAAACAAGTTGCTTACTGATTACACGGAGA

TGAAAAAGGCCATACTGCATGTGTACTGGGAGGAGTTTCAAAAGGACCCTGTCGG

GCTAATGAGCAGGGTGGCTCAGCCTGCACCTAAAAACATCGACCAGCGGAAACTC

ATCCCAGTTAAGGACGGAAATGAGAGATTGACAAGTTCAGGTTTCGCCTGCTCAC

AGTGCTGTCAACCGCTGTACGTTTATAAGTTAGAACAAGTGAATGACAAAGGAAA

GCCTCACACAAATTATTTTGGCCGGTGTAATGTCTCTGAGCATGAGCGTCTGATT

CTGTTGTCCCCGCATAAACCGGAAGCTAATGACGAGCTCGTAACCTACAGCTTGG

GGAAGTTTGGCCAAAGAGCATTGGACTTCTATTCAATCCATGTGACCCGCGAATC

CAATCATCCCGTCAAGCCCTTGGAGCAGATAGGGGGCAATAGTTGCGCTTCTGGC

CCTGTGGGCAAAGCCCTGTCCGACGCCTGTATGGGAGCCGTGGCTTCATTCCTGA

CCAAATATCAGGATATCATCTTGGAGCACCAGAAAGTGATCAAGAAAAATGAAAA

AAGGTTAGCAAACCTCAAGGATATTGCAAGCGCTAACGGCTTGGCTTTTCCTAAA

ATCACACTTCCACCTCAGCCTCACACAAAGGAAGGCATCGAGGCATACAACAATG

TGGTGGCCCAGATCGTCATCTGGGTTAACTTAAACCTGTGGCAGAAACTTAAAAT

TGGCAGGGATGAGGCAAAACCCTTACAGCGCCTGAAAGGATTCCCCAGCTTTCCA

CTGGTGGAGCGCCAGGCTAACGAAGTGGACTGGTGGGATATGGTGTGTAACGTCA

AGAAGCTCATCAATGAAAAGAAAGAGGACGGTAAAGTCTTCTGGCAGAACCTCGC

CGGTTACAAACGGCAGGAGGCGCTGTTACCTTATCTGTCGAGTGAAGAGGACCGG

AAAAAAGGCAAGAAATTTGCTCGTTATCAGTTTGGTGATTTGCTCCTACATTTGG

AGAAGAAGCACGGCGAGGACTGGGGAAAAGTATACGATGAGGCCTGGGAGAGGAT

TGACAAAAAGGTGGAGGGACTGTCAAAGCACATCAAGCTCGAAGAAGAGCGCAGA

AGCGAGGACGCCCAATCCAAAGCAGCGCTGACTGACTGGCTGCGGGCGAAGGCCA

GTTTTGTAATCGAAGGCCTTAAAGAAGCCGACAAGGATGAATTCTGCAGATGCGA

ATTAAAACTCCAGAAGTGGTACGGCGATCTCCGAGGTAAGCCTTTCGCAATCGAG

GCCGAGAATTCCATACTGGACATTAGTGGATTCAGTAAACAGTATAATTGTGCCT

TTATATGGCAGAAGGATGGTGTCAAGAAACTCAACCTGTACCTTATTATTAATTA

TTTCAAAGGCGGGAAACTGAGATTTAAGAAGATAAAGCCTGAAGCCTTTGAGGCG

AACCGATTCTACACAGTTATTAACAAGAAATCTGGTGAAATTGTACCCATGGAGG

TAAACTTCAACTTCGATGATCCCAATCTGATTATATTGCCACTAGCTTTTGGCAA

GCGGCAGGGTAGGGAATTCATTTGGAACGATTTGCTTTCACTGGAAACAGGGTCC

CTTAAGCTGGCAAACGGGAGAGTGATTGAAAAGACATTGTACAATCGGAGGACAC

GTCAGGATGAACCTGCCCTTTTCGTGGCTCTGACATTCGAGCGCAGGGAGGTTCT

GGACTCTAGCAATATCAAGCCAATGAACCTGATCGGCATAGACCGAGGAGAGAAT

ATTCCGGCTGTGATCGCACTCACCGATCCCGAAGGATGTCCCCTTTCTCGGTTCA

AGGACTCCTTAGGCAATCCAACTCATATCCTGAGAATCGGCGAGTCATACAAGGA

GAAGCAGCGAACAATTCAGGCCGCCAAGGAAGTCGAGCAGAGGCGAGCTGGCGGC

TACAGCCGTAAATACGCTAGTAAAGCTAAGAACCTGGCCGACGATATGGTGCGCA

ATACTGCTAGAGACCTGCTGTACTATGCAGTGACGCAGGACGCAATGCTGATATT

CGAGAATCTGTCCAGAGGATTCGGAAGGCAGGGCAAGCGGACGTTCATGGCCGAG

CGCCAGTATACAAGGATGGAGGATTGGTTAACGGCCAAGCTTGCCTATGAGGGGC

TACCTAGTAAGACCTATCTGTCTAAGACGCTGGCTCAATACACCAGTAAGACCTG

CTCAAACTGTGGCTTTACAATCACTTCTGCTGATTATGATAGAGTGCTCGAGAAG

CTAAAAAAAACTGCCACCGGCTGGATGACTACTATTAATGGGAAGGAACTGAAAG

TGGAAGGACAGATTACCTATTATAATCGCTACAAGCGTCAAAACGTCGTCAAGGA

CCTGTCGGTGGAATTGGACAGACTCAGTGAAGAGTCCGTGAACAATGATATCAGC

TCCTGGACAAAAGGGCGCAGTGGGGAGGCACTCAGCTTGCTTAAAAAGAGGTTTT

CACATCGGCCGGTCCAGGAGAAATTTGTCTGCCTGAACTGCGGATTCGAGACACA

CGCCGACGAGCAGGCAGCACTGAACATTGCCAGATCCTGGCTGTTCCTTAGGTCC

CAGGAATATAAGAAGTACCAGACTAACAAAACCACGGGAAACACAGATAAAAGGG

CCTTTGTCGAAACTTGGCAATCCTTTTACCGGAAGAAGTTAAAGGAAGTGTGGAA

GCCC

SEQ
ATGGATAAGAAATACTCAATAGGCTTAGCAATCGGCACAAATAGCGTCGGATGGG

ID
CGGTGATCACTGATGAATATAAGGTTCCGTCTAAAAAGTTCAAGGTTCTGGGAAA

NO:
TACAGACCGCCACAGTATCAAAAAAAATCTTATAGGGGCTCTTTTATTTGACAGT

167
GGAGAGACAGCGGAAGCGACTCGTCTCAAACGGACAGCTCGTAGAAGGTATACAC

GTCGGAAGAATCGTATTTGTTATCTACAGGAGATTTTTTCAAATGAGATGGCGAA

AGTAGATGATAGTTTCTTTCATCGACTTGAAGAGTCTTTTTTGGTGGAAGAAGAC

AAGAAGCATGAACGTCATCCTATTTTTGGAAATATAGTAGATGAAGTTGCTTATC

ATGAGAAATATCCAACTATCTATCATCTGCGAAAAAAATTGGTAGATTCTACTGA

TAAAGCGGATTTGCGCTTAATCTATTTGGCCTTAGCGCATATGATTAAGTTTCGT

GGTCATTTTTTGATTGAGGGAGATTTAAATCCTGATAATAGTGATGTGGACAAAC

TATTTATCCAGTTGGTACAAACCTACAATCAATTATTTGAAGAAAACCCTATTAA

CGCAAGTGGAGTAGATGCTAAAGCGATTCTTTCTGCACGATTGAGTAAATCAAGA

CGATTAGAAAATCTCATTGCTCAGCTCCCCGGTGAGAAGAAAAATGGCTTATTTG

GGAATCTCATTGCTTTGTCATTGGGTTTGACCCCTAATTTTAAATCAAATTTTGA

TTTGGCAGAAGATGCTAAATTACAGCTTTCAAAAGATACTTACGATGATGATTTA

GATAATTTATTGGCGCAAATTGGAGATCAATATGCTGATTTGTTTTTGGCAGCTA

AGAATTTATCAGATGCTATTTTACTTTCAGATATCCTAAGAGTAAATACTGAAAT

AACTAAGGCTCCCCTATCAGCTTCAATGATTAAACGCTACGATGAACATCATCAA

GACTTGACTCTTTTAAAAGCTTTAGTTCGACAACAACTTCCAGAAAAGTATAAAG

AAATCTTTTTTGATCAATCAAAAAACGGATATGCAGGTTATATTGATGGGGGAGC

TAGCCAAGAAGAATTTTATAAATTTATCAAACCAATTTTAGAAAAAATGGATGGT

ACTGAGGAATTATTGGTGAAACTAAATCGTGAAGATTTGCTGCGCAAGCAACGGA

CCTTTGACAACGGCTCTATTCCCCATCAAATTCACTTGGGTGAGCTGCATGCTAT

TTTGAGAAGACAAGAAGACTTTTATCCATTTTTAAAAGACAATCGTGAGAAGATT

GAAAAAATCTTGACTTTTCGAATTCCTTATTATGTTGGTCCATTGGCGCGTGGCA

ATAGTCGTTTTGCATGGATGACTCGGAAGTCTGAAGAAACAATTACCCCATGGAA

TTTTGAAGAAGTTGTCGATAAAGGTGCTTCAGCTCAATCATTTATTGAACGCATG

ACAAACTTTGATAAAAATCTTCCAAATGAAAAAGTACTACCAAAACATAGTTTGC

TTTATGAGTATTTTACGGTTTATAACGAATTGACAAAGGTCAAATATGTTACTGA

AGGAATGCGAAAACCAGCATTTCTTTCAGGTGAACAGAAGAAAGCCATTGTTGAT

TTACTCTTCAAAACAAATCGAAAAGTAACCGTTAAGCAATTAAAAGAAGATTATT

TCAAAAAAATAGAATGTTTTGATAGTGTTGAAATTTCAGGAGTTGAAGATAGATT

TAATGCTTCATTAGGTACCTACCATGATTTGCTAAAAATTATTAAAGATAAAGAT

TTTTTGGATAATGAAGAAAATGAAGATATCTTAGAGGATATTGTTTTAACATTGA

CCTTATTTGAAGATAGGGAGATGATTGAGGAAAGACTTAAAACATATGCTCACCT

CTTTGATGATAAGGTGATGAAACAGCTTAAACGTCGCCGTTATACTGGTTGGGGA

CGTTTGTCTCGAAAATTGATTAATGGTATTAGGGATAAGCAATCTGGCAAAACAA

TATTAGATTTTTTGAAATCAGATGGTTTTGCCAATCGCAATTTTATGCAGCTGAT

CCATGATGATAGTTTGACATTTAAAGAAGACATTCAAAAAGCACAAGTGTCTGGA

CAAGGCGATAGTTTACATGAACATATTGCAAATTTAGCTGGTAGCCCTGCTATTA

AAAAAGGTATTTTACAGACTGTAAAAGTTGTTGATGAATTGGTCAAAGTAATGGG

GCGGCATAAGCCAGAAAATATCGTTATTGAAATGGCACGTGAAAATCAGACAACT

CAAAAGGGCCAGAAAAATTCGCGAGAGCGTATGAAACGAATCGAAGAAGGTATCA

AAGAATTAGGAAGTCAGATTCTTAAAGAGCATCCTGTTGAAAATACTCAATTGCA

AAATGAAAAGCTCTATCTCTATTATCTCCAAAATGGAAGAGACATGTATGTGGAC

CAAGAATTAGATATTAATCGTTTAAGTGATTATGATGTCGATCACATTGTTCCAC

AAAGTTTCCTTAAAGACGATTCAATAGACAATAAGGTCTTAACGCGTTCTGATAA

AAATCGTGGTAAATCGGATAACGTTCCAAGTGAAGAAGTAGTCAAAAAGATGAAA

AACTATTGGAGACAACTTCTAAACGCCAAGTTAATCACTCAACGTAAGTTTGATA

ATTTAACGAAAGCTGAACGTGGAGGTTTGAGTGAACTTGATAAAGCTGGTTTTAT

CAAACGCCAATTGGTTGAAACTCGCCAAATCACTAAGCATGTGGCACAAATTTTG

GATAGTCGCATGAATACTAAATACGATGAAAATGATAAACTTATTCGAGAGGTTA

AAGTGATTACCTTAAAATCTAAATTAGTTTCTGACTTCCGAAAAGATTTCCAATT

CTATAAAGTACGTGAGATTAACAATTACCATCATGCCCATGATGCGTATCTAAAT

GCCGTCGTTGGAACTGCTTTGATTAAGAAATATCCAAAACTTGAATCGGAGTTTG

TCTATGGTGATTATAAAGTTTATGATGTTCGTAAAATGATTGCTAAGTCTGAGCA

AGAAATAGGCAAAGCAACCGCAAAATATTTCTTTTACTCTAATATCATGAACTTC

TTCAAAACAGAAATTACACTTGCAAATGGAGAGATTCGCAAACGCCCTCTAATCG

AAACTAATGGGGAAACTGGAGAAATTGTCTGGGATAAAGGGCGAGATTTTGCCAC

AGTGCGCAAAGTATTGTCCATGCCCCAAGTCAATATTGTCAAGAAAACAGAAGTA

CAGACAGGCGGATTCTCCAAGGAGTCAATTTTACCAAAAAGAAATTCGGACAAGC

TTATTGCTCGTAAAAAAGACTGGGATCCAAAAAAATATGGTGGTTTTGATAGTCC

AACGGTAGCTTATTCAGTCCTAGTGGTTGCTAAGGTGGAAAAAGGGAAATCGAAG

AAGTTAAAATCCGTTAAAGAGTTACTAGGGATCACAATTATGGAAAGAAGTTCCT

TTGAAAAAAATCCGATTGACTTTTTAGAAGCTAAAGGATATAAGGAAGTTAAAAA

AGACTTAATCATTAAACTACCTAAATATAGTCTTTTTGAGTTAGAAAACGGTCGT

AAACGGATGCTGGCTAGTGCCGGAGAATTACAAAAAGGAAATGAGCTGGCTCTGC

CAAGCAAATATGTGAATTTTTTATATTTAGCTAGTCATTATGAAAAGTTGAAGGG

TAGTCCAGAAGATAACGAACAAAAACAATTGTTTGTGGAGCAGCATAAGCATTAT

TTAGATGAGATTATTGAGCAAATCAGTGAATTTTCTAAGCGTGTTATTTTAGCAG

ATGCCAATTTAGATAAAGTTCTTAGTGCATATAACAAACATAGAGACAAACCAAT

ACGTGAACAAGCAGAAAATATTATTCATTTATTTACGTTGACGAATCTTGGAGCT

CCCGCTGCTTTTAAATATTTTGATACAACAATTGATCGTAAACGATATACGTCTA

CAAAAGAAGTTTTAGATGCCACTCTTATCCATCAATCCATCACTGGTCTTTATGA

AACACGCATTGATTTGAGTCAGCTAGGAGGTGACTGA

SEQ
ATGGATAAGAAGTATTCAATTGGACTTGCGATTGGCACTAACAGTGTGGGCTGGG

ID
CGGTGATTACAGACGAGTATAAGGTGCCGTCAAAAAAGTTTAAAGTTCTGGGCAA

NO:
CACTGATCGCCATTCCATCAAGAAAAACCTAATCGGGGCCCTTCTTTTTGATAGT

168
GGCGAAACGGCCGAGGCGACGCGTCTAAAACGTACCGCGCGGCGTCGCTACACCC

GACGAAAAAACCGTATTTGTTACCTTCAGGAGATCTTCAGTAACGAAATGGCTAA

GGTGGACGATTCATTCTTCCACCGTCTGGAGGAGTCCTTTTTAGTTGAAGAAGAC

AAGAAGCATGAGCGACACCCAATTTTTGGTAACATTGTCGACGAAGTCGCCTATC

ACGAAAAATATCCGACCATTTATCACCTGCGCAAAAAACTGGTCGATAGCACGGA

TAAAGCGGATCTGCGGCTTATTTACCTGGCGCTTGCCCACATGATCAAGTTCCGC

GGCCACTTCCTGATAGAAGGAGACCTGAACCCGGATAATAGCGATGTAGACAAAC

TGTTTATTCAGCTGGTCCAGACCTACAACCAGCTGTTTGAAGAAAATCCGATTAA

TGCGTCAGGCGTGGATGCGAAAGCGATACTGAGTGCCCGCCTGTCGAAATCTCGC

CGTCTCGAAAATCTGATTGCACAGCTGCCCGGCGAAAAAAAAAACGGTCTTTTTG

GCAATCTGATCGCGCTGTCACTGGGCCTGACACCAAATTTTAAGAGCAACTTCGA

CCTGGCAGAGGATGCGAAGCTTCAACTGTCGAAGGACACCTATGACGATGATCTG

GATAATCTTCTGGCACAAATCGGTGATCAGTATGCGGATTTATTCCTTGCAGCGA

AAAACCTATCTGACGCAATTCTGTTGAGCGATATCCTCCGCGTCAACACCGAAAT

CACTAAAGCCCCCCTGTCAGCGTCGATGATTAAACGTTATGATGAGCACCATCAG

GATCTGACCTTGCTAAAGGCGCTGGTGCGACAGCAGCTTCCCGAAAAATATAAAG

AGATCTTTTTTGATCAATCGAAGAATGGTTATGCCGGATACATTGATGGCGGAGC

CAGTCAGGAAGAATTTTACAAATTCATCAAACCGATCCTGGAAAAAATGGATGGC

ACAGAAGAACTGCTTGTGAAATTGAACCGGGAAGATTTACTGCGCAAACAGCGTA

CGTTCGACAACGGCTCCATACCCCATCAGATTCACTTAGGTGAGCTGCATGCAAT

ACTCCGTCGCCAGGAAGATTTTTATCCATTTTTAAAAGACAACCGTGAGAAGATT

GAAAAAATTTTAACTTTTCGTATTCCATATTACGTCGGGCCTTTGGCCCGAGGTA

ACTCTCGATTCGCCTGGATGACGAGAAAAAGCGAGGAGACCATCACTCCGTGGAA

TTTTGAAGAGGTTGTTGATAAAGGCGCGAGCGCCCAGTCGTTTATCGAACGTATG

ACCAACTTTGATAAAAATCTGCCGAATGAAAAAGTGCTTCCGAAGCATTCTCTGT

TGTATGAATATTTCACTGTGTACAATGAGTTAACGAAAGTGAAATATGTGACCGA

AGGCATGCGGAAACCTGCTTTTCTGTCCGGAGAACAGAAAAAAGCAATTGTGGAC

CTGCTGTTCAAAACGAACCGGAAAGTAACTGTGAAGCAGCTGAAAGAGGACTACT

TCAAAAAAATCGAATGCTTCGACTCAGTAGAGATCTCTGGTGTTGAAGATCGCTT

CAACGCGAGTCTGGGAACGTACCATGATTTGTTGAAAATCATCAAAGATAAAGAC

TTTCTGGATAACGAAGAGAATGAGGACATTCTTGAAGATATTGTTTTGACACTGA

CTCTGTTTGAGGATCGCGAAATGATTGAAGAGCGCCTGAAAACGTATGCCCATTT

ATTCGATGACAAAGTCATGAAGCAGCTGAAACGTCGCCGCTATACTGGGTGGGGC

AGACTTTCACGTAAATTGATCAATGGTATAAGAGACAAACAGAGCGGCAAAACTA

TCTTAGATTTCCTGAAGAGTGATGGATTTGCCAACCGGAATTTTATGCAGCTTAT

ACATGATGACTCGCTAACGTTTAAAGAAGACATTCAGAAGGCGCAGGTCAGCGGC

CAGGGTGATTCGCTGCATGAACACATTGCAAATCTTGCCGGATCGCCAGCGATCA

AAAAAGGCATCCTTCAGACAGTAAAAGTTGTGGATGAACTGGTGAAAGTAATGGG

TCGTCACAAGCCAGAAAATATTGTGATCGAAATGGCCCGGGAAAATCAGACTACT

CAAAAAGGTCAGAAAAATTCTCGCGAGCGTATGAAACGTATTGAAGAAGGCATCA

AAGAGCTAGGCAGCCAGATATTAAAGGAACATCCGGTTGAGAACACTCAGCTGCA

GAATGAAAAACTGTATCTGTATTATCTTCAGAACGGCCGTGACATGTATGTTGAT

CAAGAACTGGATATCAATCGCTTGTCCGATTATGACGTGGATCATATTGTTCCGC

AAAGCTTTCTGAAAGACGATTCTATTGACAATAAAGTACTGACACGTTCGGACAA

AAACCGTGGTAAAAGCGATAACGTACCGTCGGAAGAAGTTGTTAAGAAAATGAAA

AATTATTGGCGCCAACTCCTGAATGCTAAATTGATTACCCAGCGGAAATTTGATA

ACTTAACCAAAGCCGAGCGGGGTGGCTTAAGTGAACTGGATAAAGCGGGTTTTAT

TAAACGCCAACTGGTAGAAACCCGCCAGATAACGAAACATGTAGCTCAAATCCTC

GATAGTCGCATGAATACGAAATATGACGAAAATGATAAATTGATCCGTGAAGTAA

AAGTGATTACTCTTAAAAGCAAATTGGTATCTGATTTTCGGAAAGATTTCCAATT

CTATAAGGTGAGAGAAATTAACAATTACCATCATGCACATGATGCGTATTTAAAT

GCAGTTGTTGGCACCGCCTTAATCAAAAAATATCCGAAATTAGAATCTGAGTTCG

TGTATGGTGATTATAAAGTTTATGATGTTCGAAAAATGATTGCTAAGTCTGAACA

GGAAATCGGCAAAGCGACCGCAAAGTATTTTTTTTATAGCAATATTATGAATTTT

TTTAAAACTGAGATTACCCTGGCGAATGGCGAAATTCGCAAACGTCCTCTGATTG

AAACCAATGGCGAAACCGGCGAGATAGTATGGGACAAGGGCCGTGATTTTGCGAC

CGTCCGGAAAGTCCTGTCAATGCCGCAGGTGAATATTGTCAAGAAAACAGAAGTT

CAGACAGGCGGTTTTAGTAAAGAGTCTATTCTGCCCAAACGTAATTCGGATAAAT

TGATTGCCCGCAAGAAAGATTGGGATCCGAAGAAATATGGTGGATTCGATTCTCC

GACGGTCGCCTATAGCGTTCTAGTCGTCGCCAAGGTCGAAAAAGGTAAATCCAAA

AAACTGAAATCTGTGAAAGAACTGTTAGGCATTACAATCATGGAACGTAGTAGTT

TTGAAAAGAACCCGATCGACTTCCTCGAGGCGAAAGGCTACAAAGAAGTCAAGAA

GGATTTGATTATTAAACTCCCAAAATATTCATTATTTGAGTTAGAAAACGGTAGG

AAGCGTATGCTGGCGAGTGCTGGGGAATTACAGAAAGGGAATGAGTTAGCACTGC

CGTCAAAATATGTGAACTTTCTGTATCTGGCCTCCCATTACGAGAAACTGAAAGG

TAGCCCGGAAGATAATGAACAGAAACAACTATTTGTCGAGCAACACAAACATTAT

CTGGATGAAATTATTGAACAGATTAGTGAATTCTCTAAACGTGTTATTTTAGCGG

ATGCCAACCTTGACAAGGTGCTGAGCGCATATAATAAACACCGTGATAAACCCAT

TCGTGAACAGGCTGAAAATATCATACATCTGTTCACGTTAACCAACTTGGGAGCT

CCTGCCGCTTTTAAATATTTCGATACCACAATTGACCGCAAACGTTATACGTCTA

CAAAAGAGGTGCTCGATGCGACCCTGATCCACCAGTCTATTACAGGCCTGTATGA

AACTCGTATCGACCTGTCACAACTGGGCGGCGACTGA

SEQ
ATGGACAAGAAATATTCAATCGGTTTAGCAATAGGAACTAACTCAGTAGGTTGGG

ID
CTGTAATTACAGACGAATACAAGGTACCGTCCAAAAAGTTTAAGGTGTTGGGGAA

NO:
CACAGATAGACACTCTATAAAAAAAAATTTAATAGGCGCTTTACTTTTCGATTCA

169
GGCGAAACTGCAGAAGCGACACGTCTGAAGAGAACCGCTAGACGTAGATACACGA

GGAGAAAGAACAGAATATGTTACCTACAAGAAATTTTTTCTAATGAGATGGCTAA

GGTGGATGATTCGTTTTTTCATAGACTCGAAGAATCTTTCTTAGTTGAAGAAGAT

AAAAAACACGAAAGGCATCCTATCTTTGGAAACATAGTTGATGAGGTGGCTTACC

ATGAAAAATATCCCACTATATATCACCTTAGAAAAAAGTTGGTTGATTCAACCGA

CAAAGCGGATCTAAGGTTAATTTACCTCGCGTTGGCTCACATGATAAAATTTAGA

GGACATTTCTTGATCGAAGGTGATTTAAATCCCGATAACTCTGATGTAGATAAAC

TGTTCATCCAGTTGGTTCAAACATATAATCAGTTGTTCGAAGAGAACCCCATTAA

CGCATCAGGTGTTGATGCTAAAGCAATCTTATCAGCAAGGTTGAGCAAGAGCAGA

CGTCTGGAAAACTTGATTGCCCAATTGCCAGGTGAAAAGAAGAACGGTCTTTTTG

GAAATTTAATTGCACTTTCACTTGGGTTGACACCGAATTTTAAAAGCAATTTCGA

CCTCGCTGAGGATGCTAAACTCCAGTTATCTAAGGATACATATGACGATGATTTG

GATAATCTATTGGCCCAGATAGGTGATCAGTATGCAGATTTGTTTTTGGCAGCTA

AGAATTTATCAGATGCAATTCTACTGAGCGATATTTTAAGGGTGAATACAGAAAT

AACTAAAGCACCTTTGTCTGCATCTATGATAAAAAGATACGATGAACACCATCAA

GATCTCACACTATTAAAAGCTTTAGTTAGACAACAATTACCAGAAAAATATAAAG

AAATCTTTTTCGATCAGTCCAAGAACGGATACGCCGGCTATATAGATGGCGGTGC

CTCCCAAGAAGAATTTTACAAATTTATCAAACCCATTTTGGAAAAGATGGATGGT

ACTGAAGAATTATTGGTCAAATTAAACAGGGAAGATTTATTAAGAAAACAAAGGA

CCTTTGATAATGGTTCTATTCCACACCAAATCCATCTAGGGGAATTACATGCGAT

TCTTAGAAGACAAGAAGATTTTTATCCATTCTTGAAAGATAACAGGGAAAAGATA

GAGAAAATCTTAACTTTTAGAATTCCCTACTACGTCGGGCCCTTAGCTAGGGGGA

ATTCTAGATTCGCCTGGATGACACGCAAATCAGAAGAAACAATTACGCCTTGGAA

TTTTGAAGAAGTTGTTGATAAAGGAGCCTCTGCTCAATCTTTTATTGAACGAATG

ACCAATTTTGATAAGAATTTACCCAATGAAAAGGTCTTACCCAAACATTCACTCC

TATACGAGTACTTTACTGTTTACAATGAGTTGACAAAAGTGAAGTATGTTACCGA

GGGTATGCGAAAACCTGCTTTCTTGAGTGGTGAACAAAAGAAGGCCATTGTTGAC

TTGTTATTCAAAACTAACAGAAAGGTCACTGTGAAGCAGCTTAAAGAAGATTATT

TCAAAAAGATCGAATGTTTCGACTCGGTAGAAATTAGTGGTGTGGAAGATAGATT

TAATGCTTCTCTTGGAACATATCATGATCTACTAAAGATCATCAAAGATAAAGAT

TTCTTGGACAATGAAGAAAATGAAGATATTCTTGAAGACATCGTGTTGACACTTA

CATTGTTTGAGGACAGAGAAATGATTGAAGAAAGGCTGAAGACCTACGCCCATTT

GTTTGATGATAAAGTCATGAAACAGTTAAAGAGGAGAAGGTATACCGGATGGGGT

AGGCTGTCTCGCAAATTGATTAATGGTATTCGTGATAAACAATCGGGTAAAACAA

TCCTAGATTTCCTGAAGTCCGATGGTTTCGCCAACAGGAATTTTATGCAATTGAT

TCATGACGATTCTTTGACTTTTAAAGAGGATATTCAGAAAGCACAGGTCTCAGGA

CAGGGCGATTCACTCCATGAACATATAGCTAACCTGGCTGGCTCCCCTGCTATTA

AGAAAGGTATCTTGCAAACCGTCAAAGTAGTAGACGAACTTGTTAAAGTTATGGG

AAGACACAAACCTGAAAATATCGTTATTGAAATGGCTCGCGAAAACCAGACAACA

CAAAAGGGTCAAAAGAATTCGAGAGAGAGAATGAAGCGTATCGAAGAAGGTATTA

AAGAACTTGGGTCCCAAATACTTAAAGAACATCCAGTAGAAAACACTCAGCTTCA

AAATGAAAAATTATACTTATATTATCTTCAGAATGGCCGCGATATGTATGTTGAC

CAAGAGTTAGATATAAATAGGTTGTCTGATTACGACGTGGATCATATTGTACCTC

AATCTTTTCTAAAAGATGATTCAATTGATAATAAGGTATTAACGAGAAGTGATAA

AAATAGAGGTAAATCTGACAACGTGCCAAGCGAAGAGGTGGTGAAGAAAATGAAA

AATTATTGGCGTCAACTGTTGAACGCCAAGTTAATTACGCAGAGAAAGTTTGATA

ATCTAACAAAAGCTGAAAGAGGAGGCCTATCTGAGTTAGATAAGGCCGGTTTTAT

CAAACGTCAGTTAGTTGAAACCAGGCAAATCACGAAGCACGTTGCCCAAATTCTA

GATTCAAGGATGAATACCAAATACGATGAAAACGATAAACTGATTCGGGAAGTCA

AGGTTATAACTCTAAAAAGCAAACTAGTTTCAGATTTTCGCAAAGATTTTCAATT

TTACAAAGTTCGAGAAATCAATAATTATCATCATGCTCACGACGCGTACTTGAAC

GCGGTCGTTGGTACAGCTTTAATAAAGAAATATCCTAAACTGGAATCGGAATTTG

TATATGGGGATTACAAAGTATACGACGTGAGAAAGATGATCGCTAAATCTGAACA

AGAAATTGGGAAAGCAACTGCCAAATATTTTTTTTACAGCAACATAATGAATTTT

TTTAAAACGGAAATTACATTGGCAAATGGCGAAATTAGAAAGCGCCCATTGATAG

AGACCAATGGAGAGACTGGGGAAATCGTGTGGGATAAAGGACGTGATTTTGCCAC

AGTGAGGAAAGTGTTAAGTATGCCACAAGTTAATATTGTAAAAAAGACCGAGGTC

CAAACGGGTGGATTTAGCAAAGAATCAATTTTACCTAAGAGAAATTCAGATAAAT

TAATTGCCCGCAAAAAGGATTGGGATCCTAAAAAATATGGTGGTTTTGATTCCCC

AACAGTTGCTTACTCCGTCCTAGTTGTTGCTAAGGTTGAAAAAGGAAAGTCTAAG

AAACTTAAATCCGTAAAAGAGTTACTGGGAATTACAATAATGGAAAGATCCTCTT

TCGAAAAGAACCCTATTGACTTCTTGGAGGCGAAAGGTTATAAAGAAGTCAAAAA

AGATTTGATCATAAAACTACCAAAGTATTCTCTATTTGAATTGGAAAACGGCAGA

AAAAGGATGTTGGCAAGCGCTGGTGAACTACAAAAGGGTAACGAATTGGCATTGC

CGAGTAAATACGTGAATTTTCTATATTTGGCATCACATTACGAAAAGTTAAAGGG

ATCACCCGAGGATAACGAGCAGAAACAACTGTTTGTTGAACAACACAAACATTAT

CTTGATGAAATTATAGAACAAATTAGTGAGTTCAGTAAGAGAGTTATTTTAGCCG

ATGCAAATTTAGACAAAGTTTTATCTGCTTATAACAAACATAGAGATAAGCCTAT

AAGGGAACAAGCCGAAAATATTATTCATTTGTTTACGTTAACAAATTTAGGGGCA

CCAGCAGCATTCAAGTACTTCGATACGACTATCGATCGTAAGCGTTACACATCTA

CCAAAGAAGTTCTTGATGCAACTTTGATTCATCAATCTATAACAGGCTTATATGA

AACTAGAATCGATCTGTCACAACTTGGTGGTGACTAA

SEQ
ATGGACAAGAAGTACTCAATTGGGCTTGCTATCGGCACTAACAGCGTTGGCTGGG

ID
CGGTCATCACAGACGAATATAAGGTCCCATCAAAGAAATTCAAAGTCCTTGGCAA

NO:
TACGGACCGACATTCAATCAAGAAGAACCTGATTGGAGCTCTGCTGTTTGATTCC

170
GGTGAAACCGCCGAGGCAACACGATTGAAACGTACCGCTCGTAGGAGGTATACGC

GGCGGAAAAATAGGATCTGCTATCTGCAGGAAATATTTAGCAACGAAATGGCCAA

GGTAGACGACAGCTTCTTCCACCGGCTCGAGGAATCTTTCCTCGTGGAAGAAGAC

AAAAAGCACGAGCGCCACCCCATTTTCGGCAATATCGTGGACGAGGTAGCTTACC

ATGAAAAGTATCCAACTATTTACCACTTACGTAAGAAGTTAGTGGACAGCACCGA

TAAAGCCGACCTTCGCCTGATTTACCTAGCACTTGCACACATGATTAAGTTCCGA

GGCCACTTCTTGATAGAGGGAGACCTGAATCCTGACAATTCCGATGTGGATAAAT

TGTTCATCCAGCTGGTACAGACATACAATCAGTTGTTTGAGGAAAATCCGATTAA

TGCCAGTGGCGTGGACGCCAAGGCTATCCTGTCTGCTCGGCTTAGTAAGAGTAGA

CGCCTGGAAAATCTAATCGCACAGCTGCCCGGCGAAAAGAAAAATGGACTGTTCG

GTAATTTGATCGCCCTGAGCCTGGGCCTCACCCCTAACTTTAAGTCTAACTTCGA

CCTGGCCGAAGATGCTAAGCTCCAGCTGTCCAAAGATACT

TACGATGACGATCTCGATAATCTACTGGCTCAGATCGGGGACCAGTACGCTGACC

TGTTTCTAGCTGCCAAGAACCTCAGTGACGCCATTCTCCTGTCCGATATTCTGAG

GGTTAACACTGAAATTACAAAGGCCCCGCTGAGCGCGAGCATGATCAAAAGGTAC

GACGAGCATCACCAGGACCTCACGCTGCTGAAGGCCTTAGTCAGACAGCAACTGC

CCGAAAAGTACAAAGAAATCTTTTTCGACCAATCCAAGAACGGGTACGCCGGCTA

CATTGATGGCGGGGCTTCACAAGAGGAGTTTTACAAGTTTATCAAGCCCATCCTG

GAGAAAATGGACGGCACTGAAGAACTGCTTGTGAAACTCAATAGGGAAGACTTAC

TGAGGAAACAGCGCACATTCGATAATGGCTCCATACCCCACCAAATCCATCTGGG

AGAGTTGCATGCCATCTTGCGAAGGCAGGAGGACTTCTACCCCTTTCTTAAGGAC

AACAGGGAGAAAATCGAGAAAATTCTGACTTTCCGTATCCCCTACTACGTGGGCC

CACTTGCTCGCGGAAACTCACGATTCGCATGGATGACCAGAAAGTCCGAGGAAAC

AATTACACCCTGGAATTTTGAGGAGGTAGTAGACAAGGGAGCCAGCGCTCAATCT

TTCATTGAGAGGATGACGAATTTCGACAAGAACCTTCCAAACGAGAAAGTGCTTC

CTAAGCACAGCCTGCTGTATGAGTATTTCACGGTGTACAACGAACTTACGAAGGT

CAAGTATGTGACAGAGGGTATGCGGAAACCTGCTTTTCTGTCTGGTGAACAGAAG

AAAGCTATCGTCGATCTCCTGTTTAAAACCAACCGAAAGGTGACGGTGAAACAGT

TGAAGGAGGATTACTTCAAGAAGATCGAGTGTTTTGATTCTGTTGAAATTTCTGG

GGTCGAGGATAGATTCAACGCCAGCCTGGGCACCTACCATGATTTGCTGAAGATT

ATCAAGGATAAGGATTTTCTGGATAATGAGGAGAATGAAGACATTTTGGAGGATA

TAGTGCTGACCCTCACCCTGTTCGAGGACCGGGAGATGATCGAGGAGAGACTGAA

AACATACGCTCACCTGTTTGACGACAAGGTCATGAAGCAGCTTAAGAGACGCCGT

TACACAGGCTGGGGAAGATTATCCCGCAAATTAATCAACGGGATACGCGATAAAC

AAAGTGGCAAGACCATACTCGACTTCCTAAAGAGCGATGGATTCGCAAATCGCAA

TTTCATGCAGTTGATCCACGACGATAGCCTGACCTTCAAAGAGGACATTCAGAAA

GCGCAGGTGAGTGGTCAAGGGGATTCCCTGCACGAACACATTGCTAACTTGGCTG

GATCACCAGCCATTAAGAAAGGCATACTGCAGACCGTTAAAGTGGTAGATGAGCT

TGTGAAAGTCATGGGAAGACATAAGCCAGAGAACATAGTGATCGAAATGGCCAGG

GAAAATCAGACCACGCAAAAGGGGCAGAAGAACTCAAGAGAGCGTATGAAGAGGA

TCGAGGAGGGCATCAAGGAGCTGGGTAGCCAGATCCTTAAAGAGCACCCAGTTGA

GAATACCCAGCTGCAGAATGAGAAACTTTATCTCTATTATCTCCAGAACGGAAGG

GATATGTATGTCGACCAGGAACTGGACATCAATCGGCTGAGTGATTATGACGTCG

ACCACATTGTGCCTCAAAGCTTTCTGAAGGATGATTCCATCGACAATAAAGTTCT

GACCCGGTCTGATAAAAATAGAGGCAAATCCGACAACGTACCTAGCGAAGAAGTC

GTCAAAAAAATGAAGAACTATTGGAGGCAGTTGCTGAATGCCAAGCTGATTACAC

AACGCAAGTTTGACAATCTCACCAAGGCAGAAAGGGGGGGCCTGTCAGAACTCGA

CAAAGCAGGTTTCATTAAAAGGCAGCTAGTTGAAACTAGGCAGATTACTAAGCAC

GTGGCCCAGATCCTCGACTCACGGATGAATACAAAGTATGATGAGAATGATAAGC

TAATCCGGGAGGTGAAGGTGATTACTCTGAAATCTAAGCTGGTGTCAGATTTCAG

AAAAGACTTCCAGTTCTACAAAGTCAGAGAGATCAACAATTATCACCATGCCCAC

GATGCATATCTTAATGCAGTAGTGGGGACAGCTCTGATCAAAAAATATCCTAAAC

TGGAGTCTGAATTCGTTTATGGTGACTATAAAGTCTATGACGTCAGAAAAATGAT

CGCAAAGAGCGAGCAGGAGATAGGGAAGGCCACAGCAAAGTACTTCTTTTACAGT

AATATCATGAACTTTTTCAAAACTGAGATTACATTGGCTAACGGCGAGATCCGCA

AGCGGCCACTGATAGAGACTAACGGAGAGACAGGGGAGATTGTTTGGGATAAGGG

CCGTGACTTCGCCACCGTTAGGAAAGTGCTGTCCATGCCCCAGGTGAACATTGTG

AAGAAGACAGAAGTGCAGACGGGTGGGTTCTCAAAAGAGTCTATTCTGCCTAAGC

GGAATAGTGACAAACTGATCGCACGTAAAAAGGACTGGGATCCAAAAAAGTACGG

CGGATTCGACAGTCCTACCGTTGCATATTCCGTGCTTGTGGTCGCTAAGGTGGAG

AAGGGAAAAAGCAAGAAACTGAAGTCAGTCAAAGAACTACTGGGCATAACGATCA

TGGAGCGCTCCAGTTTCGAAAAAAACCCAATCGATTTTCTTGAAGCCAAGGGATA

CAAGGAGGTAAAGAAAGACCTTATCATTAAGCTGCCTAAGTACAGTCTGTTCGAA

CTGGAGAATGGGAGGAAGCGCATGCTGGCATCAGCTGGAGAACTCCAAAAAGGGA

ACGAGTTGGCCCTCCCCTCAAAGTATGTCAATTTTCTCTACCTGGCTTCTCACTA

CGAGAAGTTAAAGGGGTCTCCAGAGGATAATGAGCAGAAACAGCTGTTTGTGGAA

CAGCACAAGCACTATTTGGACGAAATCATCGAACAAATTTCCGAGTTCAGTAAGA

GGGTGATTCTGGCCGACGCAAACCTTGACAAAGTTCTGTCCGCATACAATAAGCA

CAGAGACAAACCAATCCGCGAGCAAGCCGAGAATATAATTCACCTTTTCACTCTG

ACTAATCTGGGGGCCCCCGCAGCATTTAAATATTTCGATACAACAATCGACCGGA

AGCGGTATACATCTACTAAGGAAGTCCTCGATGCGACACTGATCCACCAGTCAAT

TACAGGTTTATATGAAACAAGAATCGACCTGTCCCAGCTGGGCGGCGACTAG

SEQ
AAAATTCcatGCAAAATGCTCCGGTTTCATGTCATCAAAATGATGACGTAATTAA

ID
GCATTGATAATTGAGATCCCTCTCCCTGACAGGATGATTACATAAATAATAGTGA

NO:
CAAAAATAAATTATTTATTTATCCAGAAAATGAATTGGAAAATCAGGAGAGCGTT

171
TTCAATCCTACCTCTGGCGCAGTTGATATGTcaaaCAGGTtgccgtcactgcgtc

ttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattc

tgtaacaaaggggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataat

cacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgcca

tagcatttttatccataagattagcggatcctacctgacgctttttatcgcaact

ctctactgtttctccatacccgtttttttgggctagcaccgcctatctcgtgtga

gataggcggagatacgaactttaagAAGGAGatataccATGGAACAGGAATATTA

TCTGGGCTTGGACATGGGCACCGGTTCCGTCGGCTGGGCTGTTACTGACAGTGAA

TATCACGTTCTAAGAAAGCATGGTAAGGCATTGTGGGGTGTAAGACTTTTCGAAT

CTGCTTCCACTGCTGAAGAGCGTAGAATGTTTAGAACGAGTCGACGTAGGCTAGA

CAGGCGCAATTGGAGAATCGAAATTTTACAAGAAATTTTTGCGGAAGAGATATCT

AAGAAAGACCCAGGCTTTTTCCTGAGAATGAAGGAATCTAAGTATTACCCTGAGG

ATAAAAGAGATATAAATGGTAACTGTCCCGAATTGCCTTACGCATTATTTGTGGA

CGATGATTTTACCGATAAGGATTACCATAAAAAGTTCCCAACTATCTACCATTTA

CGCAAAATGTTAATGAATACAGAGGAAACCCCAGACATAAGACTAGTTTATCTGG

CAATACACCATATGATGAAACATAGAGGCCATTTCTTACTTTCCGGGGATATCAA

CGAAATCAAAGAGTTTGGTACCACATTTAGTAAGTTACTGGAAAACATAAAGAAT

GAAGAATTGGATTGGAACTTAGAACTCGGAAAAGAAGAATACGCGGTTGTCGAAT

CTATCCTGAAGGATAATATGCTGAATAGGTCGACCAAAAAAACTAGGCTGATCAA

AGCACTGAAAGCCAAATCTATCTGCGAAAAAGCTGTTTTAAATTTACTTGCTGGT

GGCACTGTTAAGTTATCAGACATTTTTGGTTTGGAAGAATTGAACGAAACCGAGC

GTCCAAAAATTAGTTTCGCTGATAATGGCTACGATGATTACATTGGTGAGGTGGA

AAACGAGTTGGGCGAACAATTTTATATTATAGAGACAGCTAAGGCAGTCTATGAC

TGGGCTGTTTTAGTAGAAATCCTTGGTAAATACACATCTATCTCCGAAGCGAAAG

TTGCTACTTACGAAAAGCACAAGTCCGATCTCCAGTTTTTGAAGAAAATTGTCAG

GAAATATCTGACTAAGGAAGAATATAAAGATATTTTCGTTAGTACCTCTGACAAA

CTGAAAAATTACTCCGCTTACATCGGGATGACCAAGATTAATGGCAAAAAAGTTG

ATCTGCAAAGCAAAAGGTGTTCGAAGGAAGAATTTTATGATTTCATTAAAAAGAA

TGTCTTAAAAAAATTAGAAGGTCAGCCAGAATACGAATATTTGAAAGAAGAACTG

GAAAGAGAGACATTCTTACCAAAACAAGTCAACAGAGATAATGGGGTAATTCCAT

ATCAAATTCACCTCTACGAATTAAAAAAAATTTTAGGCAATTTACGCGATAAAAT

TGACCTTATCAAAGAAAATGAGGATAAGCTGGTTCAACTCTTTGAATTCAGAATA

CCCTATTATGTGGGCCCACTGAACAAGATTGATGACGGCAAAGAAGGTAAATTCA

CATGGGCCGTCCGCAAATCCAATGAAAAAATTTACCCATGGAACTTTGAAAATGT

AGTAGATATTGAAGCGTCTGCGGAGAAATTTATTCGAAGAATGACTAATAAATGC

ACTTACTTGATGGGAGAGGATGTTCTGCCTAAAGACAGCTTATTATACAGCAAGT

ACATGGTTCTAAACGAACTTAACAACGTTAAGTTGGACGGTGAGAAATTAAGTGT

AGAATTGAAACAAAGATTGTATACTGACGTCTTCTGCAAGTACAGAAAAGTGACA

GTTAAAAAAATTAAGAATTACTTGAAGTGCGAAGGTATAATTTCTGGAAACGTAG

AGATTACTGGTATTGATGGTGATTTCAAAGCATCCCTAACAGCTTACCACGATTT

CAAGGAAATCCTGACAGGAACTGAACTCGCAAAAAAAGATAAAGAAAACATTATT

ACTAATATTGTTCTTTTCGGTGATGACAAGAAATTGTTGAAGAAAAGACTGAATA

GACTTTACCCCCAGATTACTCCCAATCAACTTAAGAAAATTTGTGCTTTGTCTTA

CACAGGATGGGGTCGTTTTTCAAAAAAGTTCTTAGAAGAGATTACCGCACCTGAT

CCAGAAACAGGCGAAGTATGGAATATAATTACCGCCTTATGGGAATCGAACAATA

ATCTTATGCAACTTCTGAGCAATGAATATCGTTTCATGGAAGAAGTTGAGACTTA

CAACATGGGCAAACAGACGAAGACTTTATCCTATGAAACTGTGGAAAATATGTAT

GTATCACCTTCTGTCAAGAGACAAATTTGGCAAACCTTAAAAATTGTCAAAGAAT

TAGAAAAGGTAATGAAGGAGTCTCCTAAACGTGTGTTTATTGAAATGGCTAGAGA

AAAACAAGAGTCAAAAAGAACCGAGTCAAGAAAGAAGCAGTTAATCGATTTATAT

AAGGCTTGTAAAAACGAAGAGAAAGATTGGGTTAAAGAATTGGGGGACCAAGAGG

AACAAAAACTACGGTCGGATAAGTTGTATTTATACTATACGCAAAAGGGACGATG

TATGTATTCCGGCGAGGTAATAGAATTGAAGGATTTATGGGACAATACAAAATAT

GACATAGACCATATATATCCCCAATCAAAAACGATGGACGATAGCTTGAACAATA

GAGTACTCGTGAAAAAAAAATATAATGCGACCAAATCTGATAAGTATCCTCTGAA

TGAAAATATCAGACATGAAAGAAAGGGGTTCTGGAAGTCCTTGTTAGATGGTGGG

TTTATAAGCAAAGAAAAGTACGAGCGTCTAATAAGAAACACGGAGTTATCGCCAG

AAGAACTCGCTGGTTTTATTGAGAGGCAAATCGTGGAAACGAGACAATCTACCAA

AGCCGTTGCTGAGATCCTAAAGCAAGTTTTCCCAGAGTCGGAGATTGTCTATGTC

AAAGCTGGCACAGTGAGCAGGTTTAGGAAAGACTTCGAACTATTAAAGGTAAGAG

AAGTGAACGATTTACATCACGCAAAGGACGCTTACCTAAATATCGTTGTAGGTAA

CTCATATTATGTTAAATTTACCAAGAACGCCTCTTGGTTTATAAAGGAGAACCCA

GGTAGAACATATAACCTGAAAAAGATGTTCACCTCTGGTTGGAATATTGAGAGAA

ACGGAGAAGTCGCATGGGAAGTTGGTAAGAAAGGGACTATAGTGACAGTAAAGCA

AATTATGAACAAAAATAATATCCTCGTTACAAGGCAGGTTCATGAAGCAAAGGGC

GGCCTTTTTGACCAACAAATTATGAAGAAAGGGAAAGGTCAAATTGCAATAAAAG

AAACCGATGAGAGACTAGCGTCAATAGAAAAGTATGGTGGCTATAATAAAGCTGC

GGGTGCATACTTTATGCTTGTTGAATCAAAAGACAAGAAAGGTAAGACTATTAGA

ACTATAGAATTTATACCCCTGTACCTTAAAAACAAAATTGAATCGGATGAGTCAA

TCGCGTTAAATTTTCTAGAGAAAGGAAGGGGTTTAAAAGAACCAAAGATCCTGTT

AAAAAAGATTAAGATTGACACCTTGTTCGATGTAGATGGATTTAAAATGTGGTTA

TCTGGCAGAACAGGCGATAGACTTTTGTTTAAGTGCGCTAATCAATTAATTTTGG

ATGAGAAAATCATTGTCACAATGAAAAAAATAGTTAAGTTTATTCAGAGAAGACA

AGAAAACAGGGAGTTGAAATTATCTGATAAAGATGGTATCGACAATGAAGTTTTA

ATGGAAATCTACAATACATTCGTTGATAAACTTGAAAATACCGTATATCGAATCA

GGTTAAGTGAACAAGCCAAAACATTAATTGATAAACAAAAAGAATTTGAAAGGCT

ATCACTGGAAGACAAATCCTCCACCCTATTTGAAATTTTGCATATATTCCAGTGC

CAATCTTCAGCAGCTAATTTAAAAATGATTGGCGGACCTGGGAAAGCCGGCATCC

TAGTGATGAACAATAATATCTCCAAGTGTAACAAAATATCAATTATTAACCAATC

TCCGACAGGTATTTTTGAAAATGAAATAGACTTGCTTAAGATATAAGAAATCATC

CTTAGCGAAAGCTAAGGATTTTTTTTATCTGAAATTTATTATATCGCGTTGATTA

TTGATGCTGTTTTTAGTTTTAACGGCAATTAATATATGTGTTATTAATTGAATGA

ATTTTATCATTCATAATAAGTATGTGTAGGATCAAGCTCAGGTTAAATATTCACT

CAGGAAGTTATTACTCAGGAAGCAAAGAGGATTACAGAATTATCTCATAACAAGT

GTTAAGGGATGTTATTTCC

SEQ
AATTCAAAGGATAATCAAAC

ID

NO:

172

SEQ
AATCTCTACTCTTTGTAGAT

ID

NO:

173

SEQ
AATTTCTACTGTTGTAGAT

ID

NO:

174

SEQ
AATTTCTACTAGTGTAGAT

ID

NO:

175

SEQ
AATTTCTACTATTGT

ID

NO:

176

SEQ
AATTTCTACTGTTGTAGA

ID

NO:

177

SEQ
AATTTCTACTATTGTA

ID

NO:

178

SEQ
AATTTCTACTTTTGTAGAT

ID

NO:

179

SEQ
AATTTCTACTGTTGTAGAT

ID

NO:

180

SEQ
AATTTCTACTCTTGTAGAT

ID

NO:

181

	Number	Date	Country
Parent	17692069	Mar 2022	US
Child	18945973		US
Parent	17554736	Dec 2021	US
Child	17692069		US
Parent	17387860	Jul 2021	US
Child	17554736		US
Parent	17179193	Feb 2021	US
Child	17387860		US
Parent	16819896	Mar 2020	US
Child	17179193		US
Parent	16548631	Aug 2019	US
Child	16819896		US
Parent	15896433	Feb 2018	US
Child	16548631		US
Parent	15631989	Jun 2017	US
Child	15896433		US

NUCLEIC ACID-GUIDED NUCLEASES

Information

Publication Number

Date Filed

Date Published

Inventors

Original Assignees

CPC

International Classifications

Abstract

Description

Claims

RELATED APPLICATIONS

Continuations (8)