Claims
- 1. An isolated nucleic acid molecule selected from the group consisting of:
a) a nucleic acid molecule comprising a nucleotide sequence that is at least 65% identical to the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, or a complement thereof; b) a nucleic acid molecule comprising a fragment of at least 300 nucleotides of the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, or a complement thereof; c) a nucleic acid molecule that encodes a polypeptide comprising the amino acid sequence of SEQ ID No:2; d) a nucleic acid molecule that encodes a fragment of a polypeptide comprising the amino acid sequence of seq id no:2, wherein the fragment comprises at least 15 contiguous amino acid residues of SEQ ID NO:2; and e) a nucleic acid molecule that encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 or SEQ ID NO:3 under stringent conditions:
- 2. The isolated nucleic acid molecule of claim 1, which is selected from the group consisting of:
a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3 or a complement thereof; and b) a nucleic acid molecule that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
- 3. The nucleic acid molecule of claim 1, further comprising vector nucleic acid sequences.
- 4. The nucleic acid molecule of claim 1, further comprising nucleic acid sequences encoding a heterologous polypeptide.
- 5. A host cell containing the nucleic acid molecule of claim 1.
- 6. The host cell of claim 4, which is a mammalian host cell.
- 7. A non-human mammalian host cell containing the nucleic acid molecule of claim 1.
- 8. An isolated polypeptide selected from the group consisting of:
a) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO:2; b) a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the polypeptide is encoded by a nucleic acid molecule that hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 or SEQ ID NO:3 under stringent conditions; c) a polypeptide that is encoded by a nucleic acid molecule comprising a nucleotide sequence that is at least 60% identical to a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3.
- 9. The isolated polypeptide of claim 8, comprising the amino acid sequence of SEQ ID NO:2.
- 10. The polypeptide of claim 8, further comprising heterologous amino acid sequences.
- 11. An antibody that selectively binds to a polypeptide of claim 8.
- 12. A method for producing a polypeptide selected from the group consisting of:
a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2; b) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO:2; and c) a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the polypeptide is encoded by a nucleic acid molecule that hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 or SEQ ID NO:3 under stringent conditions; the method comprising culturing the host cell of claim 5 under conditions in which the nucleic acid molecule is expressed.
- 13. The isolated polypeptide of claim 8 comprising the amino acid sequence of SEQ ID NO:2.
- 14. A method for detecting the presence of a polypeptide of claim 8 in a sample, comprising:
a) contacting the sample with a compound that selectively binds to a polypeptide of claim 8; and b) determining whether the compound binds to the polypeptide in the sample.
- 15. The method of claim 14, wherein the compound that binds to the polypeptide is an antibody.
- 16. A kit comprising a compound that selectively binds to a polypeptide of claim 8 and instructions for use.
- 17. A method for detecting the presence of a nucleic acid molecule of claim 1 in a sample, comprising the steps of:
a) contacting the sample with a nucleic acid probe or primer that selectively hybridizes to the nucleic acid molecule; and b) determining whether the nucleic acid probe or primer binds to a nucleic acid molecule in the sample.
- 18. The method of claim 17, wherein the sample comprises mRNA molecules and is contacted with a nucleic acid probe.
- 19. A kit comprising a compound that selectively hybridizes to a nucleic acid molecule of claim 1 and instructions for use.
- 20. A method for identifying a compound that binds to a polypeptide of claim 8 comprising the steps of:
a) contacting a polypeptide of claim 8, or a cell expressing a polypeptide of claim 8, with a test compound; and b) determining whether the polypeptide binds to the test compound.
- 21. The method of claim 20, wherein the binding of the test compound to the polypeptide is detected by a method selected from the group consisting of:
a) detection of binding by direct detecting of test compound/polypeptide binding; and b) detection of binding using a competition binding assay.
- 22. A method for modulating the activity of a polypeptide of claim 8, the method comprising contacting a polypeptide of claim 8 or a cell expressing a polypeptide of claim 8 with a compound that binds to the polypeptide in a sufficient concentration to modulate the activity of the polypeptide.
- 23. A method for identifying a compound that modulates the activity of a polypeptide of claim 8, comprising:
a) contacting a polypeptide of claim 8 with a test compound; and b) determining the effect of the test compound on the activity of the polypeptide to thereby identify a compound that modulates the activity of the polypeptide.
RELATED APPLICATION INFORMATION
[0001] This application is a continuation-in-part of application Ser. No. 09/107,932, filed Jun. 30, 1998.
Continuations (2)
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Number |
Date |
Country |
Parent |
09911667 |
Jul 2001 |
US |
Child |
10741259 |
Dec 2003 |
US |
Parent |
09342959 |
Jun 1999 |
US |
Child |
09911667 |
Jul 2001 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09107932 |
Jun 1998 |
US |
Child |
09342959 |
Jun 1999 |
US |