Claims
- 1. A compound of the formula
- or a physiologically tolerated salt thereof, wherein R.sub.1 is
- (a) (C.sub.1 -C.sub.6)-alkyl or
- (b) (C.sub.1 -C.sub.6)-alkyl substituted by
- 1) (C.sub.5 -C.sub.7)-cycloalkyl
- 2) amino,
- 3) (C.sub.1 -C.sub.6)-alkoxycarbonylamino,
- 4) (C.sub.1 -C.sub.6)-alkanoylamino, or
- 5) (C.sub.1 -C.sub.6)-alkoxyphenyl;
- R.sub.2 is
- (a) (C.sub.1 -C.sub.6)-alkyl,
- (b) (C.sub.1 -C.sub.6)-alkyl substituted by
- 1) (C.sub.5 -C.sub.7)-cycloalkyl,
- 2) phenoxy,
- 3) phenoxy substituted by
- 3.1 halogen,
- 3.2 methyl, or
- 3.3 methoxy,
- 4) amino,
- 5) (C.sub.1 -C.sub.6)-alkylureido,
- 6) cyclohexylureido,
- 7) phenylureido,
- 8)
- (C.sub.1 -C.sub.6)-alkylmercapto,
- (C.sub.1 -C.sub.6)-alkylsulfinyl, or
- (C.sub.1 -C.sub.6)-alkylsulfonyl,
- 9) phenylmercapto, phenylsulfinyl, or phenylsulfonyl,
- 10) benzylmercapto, benzylsulfinyl, or benzylsulfonyl,
- 11) a heterocycle selected from the group consisting of indole, imidazole, pyrrole, pyrazole, thiophene, thiazole, or
- 12) such a heterocycle substituted by
- 12.1 halogen,
- 12.2 methyl, or
- 12.3 amino; and
- wherein R.sub.3 is hydrogen, (C.sub.1 -C.sub.6)-alkyl, or benzyl.
- 2. A compound as in claim 1 which is N-(1-S-carboethoxy-2-phenoxy-ethyl)-S-alanyl-octahydroindole-2-S-carboxylic acid.
- 3. A compound as in claim 1 which is N-[1-S-carboethoxy-3-(3-indolyl)-propyl]-S-alanyl-octahydroindole-2-S-carboxylic acid.
- 4. A compound as in claim 1 which is N-[1-S-carboethoxy-3-(3-indolyl)-ethyl]-S-alanyl-octahydroindole-2-S-carboxylic acid.
- 5. A compound as in claim 1 which is N-[1-S-carboethoxy-3-(2-thienyl)-propyl]-S-alanyl-octahydroindole-2-S-carboxylic acid.
- 6. A compound as in claim 1 which is N-(1-S-carboethoxy-2-phenylthioethyl)-S-alanyl-octahydroindole-2-S-carboxylic acid.
- 7. A pharmaceutical preparation for the treatment of hypertension, said preparation comprising a hypotensively effective amount of a compound or salt as in claim 1 and a pharmaceutically acceptable carrier therefor.
- 8. A method for treating hypertension in a patient suffering therefrom, which method comprises orally, intravenously, or subcutaneously administering to said patient a hypotensively effective amount of a compound as in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3032709 |
Aug 1980 |
DEX |
|
3118191 |
May 1981 |
DEX |
|
Parent Case Info
This is a division of application Ser. No. 297,191, filed Aug. 28, 1981.
US Referenced Citations (9)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0012845 |
Jul 1980 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Burger, "Med. Chem.", 3rd Ed. vol. I, 1970, pp. 1142-1148. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
297191 |
Aug 1981 |
|