Claims
- 1. A polypeptide compound of the formula: ##STR34## in which: P is Phe or Phe(4'-Alk);
- X is D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Pba, D-Nle, D-Cha, D-Abu, D-Met, D-Chg, D-Tyr, L-Tyr, D-aIle, D-Tyr(alk) or L-Tyr(alk);
- Y is NH.sub.2, NHAlk, NHBzl or OH;
- A is Ile, Abu, Ala, Gly, Lys, Cha, Nle, Phe, Leu, Chg, Nva or, when n is 0 or 2 or W is D-Pro, Val;
- W is L-Pro, .DELTA.Pr or, when A is Val or is as defined above, D-Pro;
- Z is D-Arg, L-Arg, D-Lys or L-Lys; and
- n is 1 or, when A is Val or is as defined above, 0 or 2; or a pharmaceutically acceptable salt or prodrug derivative thereof.
- 2. The compound of claim 1 in which P is Phe or Phe(4'-Et), X is D-Tyr(alk), Y is NH.sub.2, W is D or L-Pro, A is Abu, Z is L-Arg and n is 1.
- 3. The compound of claim 1 having the formula: ##STR35##
- 4. The compound of claim 1 having the formula: ##STR36##
- 5. The compound of claim 1 having the formula: ##STR37##
- 6. The compound of claim 1 having the formula: ##STR38##
- 7. The compound of claim 1 having the formula: ##STR39##
- 8. A vasopressin-antagonistic pharmaceutical composition comprising a pharmaceutical carrier and, dispersed therein, a VSP antagonist-effective but nontoxic quantity of a compound of claim 1.
- 9. The composition of claim 8 in which the compound has the formula: ##STR40##
- 10. A composition of claim 8 in which the quantity of compound is selected from the range of 0.01-10 mg/kg and the composition is adapted for parenteral injection or insufflation.
- 11. The method of inducing a vasopressin antagonistic effect in a subject in need thereof comprising administering parenterally or by insufflation to said subject an effective therefor but nontoxic quantity of a compound of claim 1.
- 12. The method of claim 11 in which the vasopressin antagonistic effect is manifested as an aquaretic effect.
Priority Claims (1)
Number |
Date |
Country |
Kind |
84300692.5 |
Feb 1984 |
EPX |
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Parent Case Info
This is a continuation-in-part application of Ser. No. 467,117 filed Feb. 16, 1983, now U.S. Pat. No. 4,469,679, issued Sept. 4, 1984.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4367225 |
Manning et al. |
Jan 1983 |
|
4399125 |
Manning et al. |
Aug 1983 |
|
Non-Patent Literature Citations (2)
Entry |
M. Manning et al., Nature, 308 652 (1984). |
M. Manning et al., J. Med. Chem. 26, 1607-1613 (1983). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
467117 |
Feb 1983 |
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