Claims
- 1. An isolated nucleic acid encoding a origin of replication (ORC) protein, said ORC protein selected from the group consisting of ORC1 (SEQ ID NO:2, 14, 16 or 18), ORC2 (SEQ ID NO;4, 20, 22 or 24), ORC3 (SEQ ID NO:6), ORC4 (SEQ ID NO:8), ORC5 (SEQ ID NO:10) and ORC6 (SEQ ID NO:12).
- 2. An isolated nucleic acid according to claim 1, wherein said ORC protein is a human ORC protein.
- 3. An isolated nucleic acid according to claim 1, wherein said ORC protein is a fungal ORC protein.
- 4. An isolated origin of replication (ORC) hybridization probe comprising an ORC gene sequence which is a subsequence of an ORC1 transcript (SEQ ID NO:1, 13, 15 or 17), ORC2 transcript (SEQ ID NO:3, 19, 21 or 23), ORC3 transcript (SEQ ID NO:5), ORC4 transcript (SEQ ID NO:7), ORC5 transcript (SEQ ID NO;9) or ORC6 transcript (SEQ ID NO:11) or a complement thereof which specifically hybridizes with said transcript.
- 5. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is a human transcript.
- 6. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is a fungal transcript.
- 7. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC transcript.
- 8. An isolated nucleic acid according to claim 1, wherein said nucleic acid is a fungal ORC transcript.
- 9. An isolated nucleic acid according to claim 1, wherein said nucleic acid is a human ORC transcript.
- 10. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC1 transcript.
- 11. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC2 transcript.
- 12. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC3 transcript.
- 13. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC4 transcript.
- 14. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC5 transcript.
- 15. An isolated nucleic acid according to claim 1, wherein said nucleic acid is an ORC6 transcript.
- 16. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is an ORC1 transcript.
- 17. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is an ORC2 transcript.
- 18. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is an ORC3 transcript.
- 19. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is an ORC4 transcript.
- 20. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is an ORC5 transcript.
- 21. An isolated origin of replication (ORC) hybridization probe according to claim 4, wherein said transcript is an ORC6 transcript.
RELATED APPLICATION
This application is a continuation in part of Ser. No. 08/168,479 filed Dec. 16, 1993 now abandoned.
Government Interests
The research carried out in the subject application was supported in part by grants from the National Institutes of Health. The government may have rights in any patent issuing on this application.
Non-Patent Literature Citations (1)
Entry |
Micklem et al. Nature 366:87-89 1993. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
168479 |
Dec 1993 |
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