The present application generally relates to particle accelerators, including linear particle accelerators that use dielectric wall accelerators.
Particle accelerators are used to increase the energy of electrically-charged atomic particles, e.g., electrons, protons, or charged atomic nuclei. High energy electrically-charged atomic particles are accelerated to collide with target atoms, and the resulting products are observed with a detector. At very high energies the charged particles can break up the nuclei of the target atoms or molecules and interact with other particles. Transformations are produced that help to discern the nature and behavior of fundamental units of matter. Particle accelerators are also important tools in the effort to develop nuclear fusion devices, as well as in medical applications such as proton therapy for cancer treatment.
Proton therapy uses a beam of protons to irradiate diseased tissue, most often in the treatment of cancer. The proton beams can be utilized to more accurately localize the radiation dosage and provide better targeted penetration inside the human body when compared with other types of external beam radiotherapy. Due to their relatively large mass, protons have relatively small lateral side scatter in the tissue, which allows the proton beam to stay focused on the tumor with only low-dose side-effects to the surrounding tissue.
The radiation dose delivered by the proton beam to the tissue is at or near maximum just over the last few millimeters of the particle's range, known as the Bragg peak. Tumors closer to the surface of the body are treated using protons with lower energy. To treat tumors at greater depths, the proton accelerator must produce a beam with higher energy. By adjusting the energy of the protons during radiation treatment, the cell damage due to the proton beam is maximized within the tumor itself, while tissues that are closer to the body surface than the tumor, and tissues that are located deeper within the body than the tumor, receive reduced or negligible radiation.
Proton beam therapy systems are traditionally constructed using large accelerators that are expensive to build and hard to maintain. However, recent developments in accelerator technology are paving the way for reducing the footprint of the proton beam therapy systems that can be housed in a single treatment room. Such systems often require newly designed, or re-designed, subsystems that can successfully operate within the small footprint of the proton therapy system, reduce or eliminate health risks for patients and operators of the system, and provide enhanced functionalities and features.
Methods and devices enable coupling of a charged particle beam to a radio frequency quadrupole in particle acceleration systems and devices, including proton cancer therapy systems. Coupling of the charged particle beam is accomplished, at least in-part, by relying on of sensitivity of the input phase space acceptance of the radio frequency quadrupole to the angle of the input charged particle beam. A first electric field across a beam deflector causes the charged particle beam to have a first trajectory that is beyond the acceptance angle of the radio frequency quadrupole. By momentarily reversing or reducing the established electric field, a narrow portion of the charged particle beam is deflected from its initial first trajectory to a second trajectory that is within the acceptance angle of the radio frequency quadrupole.
One aspect of the present invention includes a method for coupling a charged particle beam to a radio frequency quadrupole (RFQ) that includes generating a first electric field across a particle beam deflector. The deflector is located at the entrance of the RFQ, and the first electric field causes the charged particle beam to have a first trajectory that is beyond an acceptance angle of the RFQ. This method further includes generating a second electric field for a predetermined duration, where the second electric field causes the charged particle beam to be deflected from the first trajectory to a second trajectory that is within the acceptance angle of the RFQ, thereby coupling the charged particle beam to the RFQ.
Another aspect of the present invention includes a method for coupling a charged particle beam to a radio frequency quadrupole (RFQ) that includes generating a first electric field across a particle beam deflector, where the deflector is located at the entrance of the RFQ, and the first electric field causes the charged particle beam to be delivered to the RFQ at an angle that is within an acceptance angle of the RFQ. The method also includes generating a second electric field for a predetermined duration, where the second electric field causes the charged particle beam to be deflected at an angle that is beyond the acceptance angle of the RFQ.
Another aspect of the present invention includes a device for coupling a charged particle beam to a radio frequency quadrupole (RFQ). The device comprises a particle beam deflector configured to deflect the charged particle beam at an angle that is beyond an acceptance angle of the RFQ when a first electric field is generated across the particle beam deflector, and to deflect the charged particle beam at an angle that is within the acceptance angle of the RFQ when a second electric field is generated across the particle beam deflector. This device also includes one or more voltage sources configured to supply voltages to the particle beam deflector for establishing the first and the second electric fields.
Another aspect of the present invention includes a device for coupling a charged particle beam to a radio frequency quadrupole (RFQ) that comprises a particle beam deflector configured to deliver the charged particle beam to the RFQ at an angle that is within an acceptance angle of the RFQ when a first electric field is generated across the particle beam deflector, and to deflect the charged particle beam at an angle that is beyond the acceptance angle of the RFQ when a second electric field is generated across the particle beam deflector. This device also includes one or more voltage sources configured to supply voltages to the particle beam deflector for establishing the first and the second electric fields.
In the specific example in
In a first position of the switch 12, as shown in
Multiple DWA cells 10 may be stacked or otherwise arranged over a continuous dielectric wall, to accelerate the proton beam using various acceleration methods. For example, multiple DWA cells may be stacked and configured to produce together a single voltage pulse for single-stage acceleration. In another example, multiple DWA cells may be sequentially arranged and configured for multi-stage acceleration, wherein the DWA cells independently and sequentially generate an appropriate voltage pulse. For such multi-stage DWA systems, by timing the closing of the switches (as illustrated in
The disclosed embodiments facilitate the coupling of a charged particle beam to an RFQ in a linac system by producing narrow beam pulses with fast rise and fall times, while maintaining proper synchronization between the various components of the linac. To facilitate the understanding of the disclosed embodiments, consider an exemplary linac configuration in which an ion source produces a low energy proton beam (e.g., 35 keV) comprised of pulses with duration 5-20 μs, and an RFQ that operates at a frequency of 425 MHz. The low energy proton beam may be shaped with one or more Einzel lenses as part of the transport from the ion source to the RFQ. The normal output of the RFQ in such an exemplary configuration is typically a 5-10 μs train of micropulses, where each pulse is approximately 200-500 ps long and is separated from other pulses in the train by one RF period (i.e., 2.35 ns for the 425 MHz operating frequency).
According to some embodiments, a narrow portion of the proton beam generated by the ion source is coupled to the RFQ. In particular, the disclosed embodiments utilize a beam deflector (also referred to as a “kicker”) that is placed at the entrance of the RFQ such that the RFQ is filled with a short proton beam for the duration of a single RF cycle (or period). The rise and fall times of the deflected proton pulse are sufficiently small to ensure that the beam injected into the RFQ substantially fills the complete RF cycle, while minimizing the spread into adjacent RF cycles. In order for the proton beam to be transported, accelerated and bunched by the RFQ, the beam must be matched to the RFQ's input acceptance. Such an acceptance can be characterized in a phase space comprising space, momentum, and/or angular coordinates. The beam deflection methodologies and mechanisms of the disclosed embodiments facilitate the slicing of a continuous low energy beam (or pulsed beams with long pulse widths) by exploiting, in-part, the sensitivity of the input phase space acceptance of the RFQ to the angle of the input beam.
Slicing a portion from a continuous beam is typically done using one or more deflection plates and physical apertures that are located between the ion source and the intended destination, which in this case would be the entrance to the RFQ. Such techniques use the physical boundary of the final aperture as a spatial acceptance to define the temporally selected beam. One problem associated with such techniques is that the transit time of the low energy beam (e.g., 35 keV beam) across the deflection plates is comparable or larger than the desired pulse width (e.g., 2.35 ns for an RFQ operating at 425 MHz). In these systems, the beam transport from the ion source to the RFQ also often passes through an Einzel lens to provide focusing. This transport mechanism produces further spread in transit times (e.g., in the order of a few nanoseconds) due to, for example, path length differences introduced by the Einzel lens. As such, even a perfect square voltage pulse that is applied to the deflection plates will result in a deflection that ramps up for approximately the proton transit time through the deflection plates. Therefore, such a configuration does not allow for maximal transmission into the RFQ during the intended pulse operation.
The above noted problems can be mitigated by placing at the RFQ entrance a beam deflector that is shorter than or comparable in length to the proton speed multiplied by the RFQ period. The beam deflector is configured to operate at a first DC bias level. The electric field that is generated due to the first DC bias level deflects the protons to modify their trajectory such that the modified trajectory is at an angle that is beyond the acceptance angle of the RFQ. Under these conditions (e.g., default conditions), the proton beam is not coupled to the RFQ. A narrow proton pulse, however, can be generated and directed to the RFQ (i.e., at an angle that is within the acceptance angle of the RFQ) by applying an impulse voltage to the beam deflector with an opposite polarity of the first DC bias level. The applied pulse momentarily modifies (e.g., negates) the electric field across the beam deflector, thereby allowing the proton beam to be coupled to the RFQ.
Upon application of a negative pulse to the beam deflector 304, the voltage across the beam deflector 304 is momentarily reduced to a second voltage value 314, which results in the elimination (or reduction) of the field across the beam deflector 304. As a result, the proton beam 302, for the duration of the negative pulse, follows the proton beam original path 310, entering the RFQ 306 at a second trajectory and angle (different from the first trajectory and angle) that is within the acceptance angle of the RFQ 306. This operation is shown in
In one example, the first DC voltage value 312 is a positive voltage value and the second voltage value 314 is 0. In one variation of the above example, the second voltage value 314 is a positive voltage value smaller than the first DC voltage value 312. In still another variation, the second voltage value 314 is a negative voltage value. In another example, the first DC voltage value 312 is a negative value and the absolute value of the second voltage value 314 is smaller than the absolute value of the first DC voltage value 312. In another example embodiment, the first DC voltage value is zero, or is nearly zero, allowing the proton beam to have a trajectory that is outside of the acceptance angle of the RFQ, and the second voltage is non-zero valued, causing the proton beam to have a trajectory that is within the acceptance angle of the RFQ. The electric field established by the zero-valued (or nearly zero-valued) voltage source is a zero-valued (or nearly zero-valued) field.
By using a short impulse kicking voltage, as illustrated in
Another feature of the exemplary beam deflection system that is depicted in
In some example embodiments, a voltage pattern inverse to that shown in
In another exemplary embodiment that is shown in
The duration of the “kick” that is applied to the beam deflector in accordance with certain embodiments is selected to be roughly equal to the desired proton pulse length (e.g., 2.35 ns corresponding to 425 MHz RFQ operating frequency). In an optimal scenario, the kicking voltage would be an impulse (short relative to the time of proton transit through the deflection plates) applied to plates of length equal to the low energy proton speed multiplied by the desired pulse length. Thus all protons between the beam deflector plates receive the same kick and could all then optimally match the RFQ acceptance for maximal transmission and minimal spillage into neighboring RFQ cycles. However, the generation of a true high voltage impulse may not be feasible due to limitations in the various impulse generation technologies. For example, in certain commercially available technologies, pulses with full-width-half-maximum (FWHM) values of about 500 ps can readily be produced, but at higher unit cost. However, it is understood that the disclosed embodiments are applicable to future systems that can produce high voltage impulses of much narrower FWHM. Such optimal impulse kicking also requires minimizing the fringe (or edge) fields of the deflection plates that is described in the following section.
Another consideration in designing the beam deflection systems of the present application is the fringe (or edge) field effects. In particular, the electric field strength at the edges of the deflection plates may be different from the field strength at the center of the plates. This non-uniformity in electric field may result in a non-uniform kick, as protons that are located within the edge field may receive a weaker kick than those at the center of the plates. As a result, the rise time of the deflection is further increased. According to an example embodiment, the edge effects are reduced by narrowing the separation between the deflection plates. In another example embodiment, the edge effects are mitigated by shaping the deflection plates to reduce the field non-uniformity and produce a beam profile that resembles a “flattop.” In the latter example, the deflection plates are shaped to produce a non-uniform electric field that compensates (e.g., negates) the non-uniformities that exist in electric field of the parallel plate configuration.
To preserve the rise time of the voltage pulse, either coaxial cables or stripline transmission lines that are matched to the impedance of the pulse generator may be used to deliver the voltages to the beam deflector plates. Further, the plates of the beam deflector can be matched to the transmission line, and the DC blocks may be impedance matched.
In one example embodiment, a beam deflector 600 with the following characteristics is constructed: the plate length 606 is 8 mm, the gap 608 is in 9 mm, the area of each kicker plate is 160 mm2, the upper kicker plate thickness T1610 and lower kicker plate thickness T2612 are each 5.7 mm, the capacitors 614 and 616 are each 680 pF, the resistor/inductors 622 and 622 are each 1.5 MOhm. The above exemplary configuration of the beam deflector 600, when supplied with +6.2 kV and −6.2 kV on the lower DC bias line 624 and the upper DC bias line 620, respectively, and pulsed with a +3.7 kV and a −3.7 kV pulse of duration 2.5 (or 4 ns) ns on the upper coaxial line 628 and the lower coaxial line 618, respectively, is capable of producing a chopped proton beam with a duration of approximately 2.35 ns (or 4.7 ns), with rise and fall times below 500 ps. One or more DC voltage sources and one or more pulse generators may be used to supply the DC and pulse voltages. It should be noted that the above stated values are subject to manufacturers' and manufacturing tolerances. Further, in other embodiments, a beam deflector with different component values and sizes may be construed based on the disclosed principles. For example, in some embodiments, the configuration of the beam deflector can produce chopped particle beams with durations in the range 2 to 4.7 ns.
Synchronization between the various components of the linac is a critical factor for proper generation and control of the output proton beam. In the context of the exemplary linac of
The DG645 has 100-200 ps timing jitter. In one embodiment, the jitter performance of the trigger signals is improved by utilizing a gating mechanism.
In one embodiment, the timing and control components 116 of
In one example embodiment, the above noted set of operations includes using two substantially parallel plates as part of the particle beam deflector, configuring the two substantially parallel plates to allow propagation of the charged particle beam through the plates, and establishing a first voltage difference across the plates to generate the first electric field. Such an example embodiment can also include applying a voltage pulse of a second voltage value that is opposite in polarity to the first voltage difference to generated the second electric field. Further, the absolute value of the second voltage value can be selected to be one of: a value that is less than absolute value of the first voltage difference, a value that is equal to absolute value of the first voltage difference, and a value that is greater than absolute value of the first voltage difference.
According to another embodiment, the duration of the coupled charged particle beam is substantially equal to one period of RFQ's operating radio frequency. In the example, embodiment, where the second electric field is generated by applying a voltage pulse of a second voltage value that is opposite in polarity to the first voltage difference, the duration of the voltage pulse can be in a range 2 to 4.7 nanoseconds, and the RFQ operates at 425 MHz. According to an example embodiment, the charged particle beam is a proton beam.
In another example embodiment, the particle beam deflector is configured to reduce non-uniformities of one or both of the first and the second electric fields. For example, the particle beam deflector can include two plates that are configured to allow propagation of the charged particle beam through the plates, where the first electric field is generated by establishing a first voltage difference across the plates and the second electric field is generated by establishing a second voltage difference across the plates. In this example, at least one of the plates can include a non-uniform surface area adapted to reduce the non-uniformities of the first and/or the second electric fields.
In yet another example embodiment, a lens can be used that is located between the particle beam deflector and entrance of the RFQ to focus the charged particle beam that is deflected within the acceptance angle of the RFQ. In another embodiment, timing synchronization is maintained with operations of at least an ion source, the RFQ, a dielectric wall accelerator (DWA), a Blumlein device and a laser.
In still another embodiment, a device for coupling a charged particle beam to a radio frequency quadrupole (RFQ) is provided. Such a device includes a particle beam deflector that is configured to deflect the charged particle beam at an angle that is beyond an acceptance angle of the RFQ when a first electric field is generated across the particle beam deflector. The particle beam deflector is further configured to deflect the charged particle beam at an angle that is within the acceptance angle of the RFQ when a second electric field is generated across the particle beam deflector. The above noted device also includes one or more voltage sources that are configured to supply voltages to the particle beam deflector for establishing the first and the second electric fields.
In one example embodiment, the one or more voltage sources in the aforementioned device include at least one direct current (DC) voltage source configured to supply voltages to the particle beam deflector to generate the first electric field, as well as a pulse generator that is configured to supply one or more pulses of a predetermined duration to the particle beam deflector to generate the second electric field.
In some embodiments, one or more additional deflection mechanisms (e.g., deflection plates) can be located at one or both sides of the kicker to facilitate the deflection of the charged particle beam. For example, with reference to
In certain configurations, a proton beam that is accepted by the RFQ may include additional protons that are coupled to adjacent RFQ cycles. This phenomenon is sometimes referred to as a “spill-over.” In some applications, the existence of pre-pulse and post-pulse protons due to the spill-over may be tolerated. Therefore, in some embodiments where, for example, the existing state of the technology and/or implementation costs, make the generation of a singular proton bunch of a particular duration infeasible, the beam deflection components and the associated parameters may be designed to allow some spill over. Moreover, regardless of the state of technology or cost considerations, in applications that can tolerate spill-overs to adjacent RFQ cycles, the amount or percentage of spill-over can be used as another adjustable parameter to facilitate proper coupling of the proton beam to the RFQ.
It is understood that the various embodiments of the present disclosure may be implemented individually, or collectively, in devices comprised of various hardware and/or software modules and components. In describing the disclosed embodiments, sometimes separate components have been illustrated as being configured to carry out one or more operations. It is understood, however, that two or more of such components can be combined together and/or each component may comprise sub-components that are not depicted. Further, the operations that are described in the form of the flow charts in
In some examples, the devices that are described in the present application can comprise a processor, a memory unit and an interface that are communicatively connected to each other. For example,
Various embodiments described herein are described in the general context of methods or processes, which may be implemented in one embodiment by a computer program product, embodied in a computer-readable medium, including computer-executable instructions, such as program code, executed by computers in networked environments. A computer-readable medium may include removable and non-removable storage devices including, but not limited to, Read Only Memory (ROM), Random Access Memory (RAM), compact discs (CDs), digital versatile discs (DVD), Blu-ray Discs, etc. Therefore, the computer-readable media described in the present application include non-transitory storage media. Generally, program modules may include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. Computer-executable instructions, associated data structures, and program modules represent examples of program code for executing steps of the methods disclosed herein. The particular sequence of such executable instructions or associated data structures represents examples of corresponding acts for implementing the functions described in such steps or processes.
The foregoing description of embodiments has been presented for purposes of illustration and description. The foregoing description is not intended to be exhaustive or to limit embodiments of the present invention to the precise form disclosed, and modifications and variations are possible in light of the above teachings or may be acquired from practice of various embodiments. The embodiments discussed herein were chosen and described in order to explain the principles and the nature of various embodiments and its practical application to enable one skilled in the art to utilize the present invention in various embodiments and with various modifications as are suited to the particular use contemplated. For example, the exemplary embodiments have been described in the context of proton beams. It is, however, understood that the disclosed principals can be applied to other charged particle beams. Moreover, the generation of extremely short charged particle pulses that are carried out in accordance with certain embodiments may be used in a variety of applications that range from radiation for cancer treatment, probes for spherical nuclear material detection or plasma compression, or in acceleration experiments. The features of the embodiments described herein may be combined in all possible combinations of methods, apparatus, modules, systems, and computer program products.
This application claims priority from U.S. Provisional Application No. 61/390,529, filed on Oct. 6, 2010, the entire contents of which is hereby incorporated by reference.
The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the United States Department of Energy and Lawrence Livermore National Security, LLC for the operation of Lawrence Livermore National Laboratory.
Number | Date | Country | |
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61390529 | Oct 2010 | US |