Claims
- 1. An unglycosylated protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts.
- 2. A therapeutic composition comprising an unglycosylated protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B- chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier or diluent.
- 3. A method for enhancing the wound-healing process in warm-blooded animals, comprising administering to the animal a therapeutically effective amount of a composition comprising an unglycosylated protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier.
- 4. The method of claim 3 wherein said carrier is selected from the group consisting of albumin, sterile water, polyethylene glycol and saline.
- 5. The method of claim 3 wherein said composition includes an adjuvant.
- 6. The method of claim 3 wherein said composition is administered topically.
- 7. The method of claim 3 wherein said composition is administered in a dose of from about 0.5 to about 10 .mu.g per cm.sup.2 of wound area.
- 8. The method of claim 3 wherein said composition includes an effective amount of basic fibroblast growth factor.
- 9. The method of claim 8 wherein the protein homodimer and the fibroblast growth factor are present in a ratio of from approximately 1 to 0.4, to 10 to 0.4, respectively.
- 10. The method of claim 3 wherein said warm-blooded animal is a diabetic animal.
CROSS-REFERENCES TO RELATED APPLICATIONS
This application is a continuation of U.S. patent application Ser. No. 07/906,544, filed Jun. 30, 1992, now abandoned; which was a division of U.S. patent application Ser. No. 07/230,190, filed Aug. 8, 1988, which issued as U.S. Pat. No. 5,128,321; which was a continuation-in-part of U.S. patent application Ser. No. 06/896,485, filed Aug. 13, 1986, now U.S. Pat. No. 4,766,073 and U.S. patent application Ser. No. No. 06/941,970, filed Dec. 15, 1986, which issued as U.S. Pat. No. 4,849,407.
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