Penam derivatives

Abstract

A compound of the general formula: ##STR1## wherein R.sup.1 is amino or a conventional, pharmaceutically acceptable acylamino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR2## R.sup.3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido, thiocyanato, lower alkyanoylthio and piperidinothiocarbonylthio.

Description

Claims

1. A compound of the general formula: ##STR246## wherein R.sup.1 is amino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR247## R.sup.3 is lower alkyl and Y" is thiocyanato.

2. The compound according to claim 1, in which R.sup.2 is carboxy, lower alkoxycarbonyl, trihalo(lower)alkoxycarbonyl or carboxy salt.

3. The compound according to claim 2, in which R.sup.2 is carboxy, methoxycarbonyl, 2,2,2-trichloroethoxycarbonyl or a carboxy salt with N,N'-dibenzylethylenediamine, R.sup.3 is a methyl and X is --S--.

4. The compound according to claim 3, which is 2,2,2-trichloroethyl 2-thiocyanatomethyl-2-methyl-6-aminopenam-3-carboxylate toluenesulfonate.