Claims
- 1. A method for selectively opening the S, --C.sub.5 bond of the thiazolidine ring of a compound selected from the group consisting of a 6-acylamido penicillin ester and a 6-imido penicillin ester comprising reacting the penicillin ester with an alkanoyl hypohalite in an aprotic solvent.
- 2. A method as defined in claim 1 wherein the alkanoyl hypohalite is generated in situ by reaction of halogen with an aliphatic carboxylic acid.
Parent Case Info
This is a continuation application of copending application Ser. No. 522,539, filed Nov. 11, 1974, now abandoned, which in turn was a divisional application of the then copending application Ser. No. 273,550, filed July 20, 1972, now U.S. Pat. No. 3,860,577. The latter application was a division of application Ser. No. 148,129, filed May 28, 1971, now abandoned.
US Referenced Citations (3)
Non-Patent Literature Citations (7)
Entry |
J. M. Steward et al., J. Amer. Chem. Soc. 24, 5880 (1952). |
S. Kukolja, J. Amer. Chem. Soc, 93, 6268. |
Barton et al., Chem. Comm. 1971, 1137-1139. |
Douglass et al., J. Org. Chem. 15, 795 (1950). |
Bailar et al., "Comprehensive Chemistry", vol. 2, pp. 858, 1344-1347. |
Kharasch et al., "Organic Synthesis", vol. 44, pp. 47-50. |
B. Taub, J. Org. Chem. 25, 263-264 (1960). |
Divisions (2)
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Number |
Date |
Country |
Parent |
273550 |
Jul 1972 |
|
Parent |
148129 |
May 1971 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
522539 |
Nov 1974 |
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