Claims
- 1. A compound of the formula ##STR55## wherein R.sub.1 is hydrogen or pivaloyloxymethyl, and
- R.sub.2 is 4-hydroxyphenyl or 1,4-cyclohexadien-1-yl, and
- R.sub.3 is hydrogen, lower alkylthio, and
- R.sub.4 and R.sub.5 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, carboxyl, lower alkoxycarbonyl, lower alkoxycarbonylmethyl or halogen, and
- A is the group ##STR56## in which R.sub.6 is hydrogen or lower alkyl, and B is oxygen or sulphur, and
- D is a 5- or 6-membered, unsaturated ring, which may contain one or more nitrogen, oxygen or sulphur group,
- or a pharmaceutically acceptable salt thereof when R.sub.1 is hydrogen.
- 2. A compound of claim 1 wherein R.sub.2 is 4-hydroxyphenyl.
- 3. A compound of claim 1 wherein R.sub.2 is 1,4-cyclohexadiene-1-yl.
- 4. A compound of the formula ##STR57## wherein B is oxygen, and
- R.sub.1, R.sub.2 and R.sub.4 are as defined in claim 1, or a pharmaceutically acceptable salt thereof when R.sub.1 is hydrogen.
- 5. A compound of the formula ##STR58## wherein B is sulphur and
- R.sub.1, R.sub.2 and R.sub.4 are as defined in claim 1, or a pharmaceutically acceptable salt thereof when R.sub.1 is hydrogen.
- 6. The compound of claim 1, which is 6-{N-[6-fluorothiochromon-3-carbonyl]-[(4-hydroxyphenyl)glycylamino]}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-[3,2,0]-hepten-2-carboxylic acid, and salt thereof.
- 7. The compound of claim 1, which is 6-{N-[chromon-3-carboxyl]-[(4-hydroxyphenyl)glycylamino]}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-[3,2,0]-hepten-2-carboxylic acid, and salt thereof.
- 8. A method of combatting bacteria comprising administrating to a subject in need of such treatment an effective amount of a compound of claim 1, or a pharmacologically acceptable salt thereof.
- 9. A pharmaceutical composition which comprises an anti-bacterial effective amount of a compound of claim 1, or a pharmacologically acceptable salt thereof, in association with a pharmacologically acceptable diluent or carrier.
Priority Claims (1)
Number |
Date |
Country |
Kind |
413/78 |
Jan 1978 |
SEX |
|
Parent Case Info
This application is a continuation in part of copending application Ser. No. 3,846 filed Jan. 16, 1979 which is now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3939150 |
Murakami et al. |
Feb 1976 |
|
4005075 |
Yamada et al. |
Mar 1977 |
|
4159268 |
Curran et al. |
Jun 1979 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
3846 |
Jan 1979 |
|