Claims
- 1. A cyclic peptide having the formula
- ti a--X--b
- wherein:
- X is a sequence of at least six amino acids taken as a block from the amino acid sequence of the E1 glycoprotein of a strain of rubella virus that corresponds to AA.sub.213 -AA.sub.252 of the E1 glycoprotein of the Judith strain of rubella virus as set forth in FIG. 1, which block maintains the sequence and N terminus to C terminus direction of the native amino acid sequence;
- a is selected from the group consisting of:
- (i) an amino terminus;
- (ii) one to eight amino acids taken as a block from and maintaining the sequence and N terminus to C terminus direction of that portion of the native amino acid sequence of the E1 glycoprotein immediately N-terminal to X; and
- (iii) a substituent effective to facilitate coupling of the peptide to another moiety; and
- b is selected from the group consisting of:
- (i) a carboxy terminus;
- (ii) one to eight amino acids taken as a block from and maintaining the sequence and N terminus to C terminus direction of that portion of the native amino acid sequence of the E1 glycoprotein immediately C-terminal to X; and
- (iii) a substituent effective to facilitate coupling of the peptide to another moiety.
- 2. The peptide according to claim 1 wherein X is an amino acid sequence selected from the group consisting of AA.sub.213 -AA.sub.239, AA.sub.219 -AA.sub.239 and AA.sub.234 -AA.sub.252.
- 3. The peptide according to claim 1 wherein the peptide is BCH-140 cyclic.
- 4. The peptide according to claim 1 wherein the peptide is BCH-178 cyclic.
- 5. The peptide according to claim 1 wherein the peptide is BCH-139 cyclic.
- 6. A pharmaceutically acceptable composition comprising a peptide according to any one of claims 1 to 5, said peptide being present in the composition in an amount effective in a mammal treated with the composition to raise antibodies.
- 7. The composition according to claim 6 including a physiologically acceptable carrier.
- 8. The composition according to claim 7 including an adjuvant or enhancer of the immune response.
- 9. A cyclic peptide having the formula
- a--X--b
- wherein:
- X is a sequence of at least six amino acids taken as a block from the amino acid sequence of the E1 glycoprotein of a strain of rubella virus that corresponds to AA.sub.213 -AA.sub.239 of the E1 glycoprotein of the Judith strain of rubella virus as set forth in FIG. 1, which block maintains the sequence and N terminus to C terminus direction of the native amino acid sequence and analogues thereof, said analogues resulting from conservative substitutions in or modifications to the native amino acid sequence block;
- a is selected from the group consisting of:
- (i) an amino terminus;
- (ii) one to eight amino acids taken as a block from and maintaining the sequence and N terminus to C terminus direction of that portion of the native amino acid sequence of the E1 glycoprotein immediately N-terminal to X or conservative substitutions in or modifications thereto; and
- (iii) a substituent effective to facilitate coupling of the peptide to another moiety; and
- b is selected from the group consisting of:
- (i) a carboxy terminus;
- (ii) one to eight amino acids taken as a block from and maintaining the sequence and N terminus to C terminus direction of that portion of the native amino acid sequence of the E1 glycoprotein immediately C-terminal to X or conservative substitutions in or modifications thereto; and
- (iii) a substituent effective to facilitate coupling of the peptide to another moiety.
- 10. The pharmaceutically acceptable composition according to claim 6, wherein said mammal is a human, and wherein said antibodies are sufficient to protect the human treated with the composition from rubella viral infections.
- 11. The peptide according to claim 9, wherein the peptide is BCH-178 cyclic and analogues thereof.
Parent Case Info
This application is a division of Ser. No. 07/397,767, filed Aug. 23, 1989, now U.S. Pat. No. 5,164,481.
Foreign Referenced Citations (1)
Number |
Date |
Country |
230883 |
Jul 1983 |
CSX |
Divisions (1)
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Number |
Date |
Country |
Parent |
397767 |
Aug 1989 |
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