Caras et al., “Signal peptide for protein secretion directing glycophospholipid membrane anchor attachment”, Science, vol. 243:1196-1198 (1989). |
Cwirla et al., “Peptides on phage: A vast library of peptides for identifying ligands”, Proc. Natl. Acad. Sci. USA, vol. 87:6378-6382 (1990). |
Dower et al., The search for molecular diversity (II): Recombinant and synthetic randomized peptide libraries:, Ann. Rep. Med. Chem., vol. 26:271-280 (1991). |
Dower et al., “High efficiency transformation of E.coli by high voltage electroporation”, Nucleic Acids Research, vol. 16:6127 (1988). |
Fodor et al., “Light-directed, spatially addressable parallel chemical synthesis”, Science, vol. 251:767-773 (1991). |
Harker, “Kinetics of thrombopoiesis”, J. Clin. Invest., vol. 47:458-465 (1968). |
Kaushansky et al., “Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin”, Nature, vol. 369:568-571 (1994). |
Kojima et al., Molecular cloning and expression of megakaryocyte potentiating factor cDNA, J. Biol. Chem., vol. 270:21984-21990 (1995). |
Kuter et al., “The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production”, Proc. Natl. Acad. Sci. USA, vol. 91:11104-11108 (1994). |
McDonald, “Thrombopoietin—Its biology, clinical aspects and possibilites”, Am. J. Pediatric Hematology/Oncology, vol. 14:8-21 (1992). |
Metcalf, “Thrombopoietin—at last”, Nature, vol. 369:519-520 (1994). |
Methia et al., “Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis”, Blood, vol. 82:1395-1401 (1993). |
Mossmann, “Rapid colorimetirc assays for cellular growth and survival: Application to proliferation and cytotoxicity assays”, J. Immunol. Methods, vol. 65:55-63 (1983). |
Or et al., Cysteine alkylation in unprotected peptides: Synthesis of a carbavasopressin analogue by intramolecular cysteine alkylation, J. Org. Chem., vol. 56:3146-3149 (1991). |
de Sauvage et al., “Stimulation of megakaryoctyopoiesis and thrombopoiesis by the c-Mpl ligand”, Nature, vol. 369:533-538 (1994). |
Souyri et al., A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors, Cell, vol. 63:1137-1147 (1990). |
Vigon et al., “Molecular cloning and characterization of MPL, the human hormolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily”, Proc. Natl. Acad. Sci. USA, vol. 89:5640-5644 (1992). |
Verber et al., “The design of metabolically-stable peptide analogs”, Trends in Neurosciences (TINS), pp. 392-396 (1990). |
Wendling et al., “The oncogene V-MPL, A putative truncated cytokine receptor which immortalizes hematopoietic progenitors”, L'Inserm, pp. 145-146 (1992). |
Wendling et al., c-Mpl ligand is a humoral regulator of megakaryocytopoisis, Nature:571-574 (1994). |
Kato et al., Purification and Characterization of Thrombopoietin38 , J. Biochem, vol. 118:229-236 (1995). |
Wada et al., “Characterization of the Truncated Thrombopoietin Variants”, Biophysical Research Communications, vol. 213:1091-1098 (1995). |
Barker et al., “Cyclic RGE peptide analogues as antiplatelet antithrombotics”, J. Med. Chem., vol. 35:2040-2048 (1992). |
Bartley et al., “Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl”, Cell, vol. 77:1117-1124 (1994). |
Bazan, “Structural design and molecular evolution of a cytokine receptor superfamily”, Proc. Natl. Acad. Sci. USA, vol. 87:6934-6938 (1990). |