Claims
- 1. A peptide derivative having the formula:
- 2. A peptide derivative according to claim 1 wherein X1 is acetyl.
- 3. A peptide derivative according to claim 1 wherein Z is amino-2-naphthyl-carboxylic acid.
- 4. A peptide derivative according to claim 1 wherein Z is histidine.
- 5. A peptide derivative according to claim 1 wherein Q is (D)phenylalanine.
- 6. A peptide derivative according to claim 1 wherein Q is p-iodo-(D)phenylalanine.
- 7. A peptide derivative according to claim 1 having the formula:
acetyl-[amino-2-naphthylcarboxylic acid]-(D)phenylalanine-arginine-tryptophan-NH2, or a pharmacologically acceptable salt, complex or derivative thereof.
- 8. A peptide derivative according to claim 1 having the formula:
acetyl-histidine-p-iodo-(D)phenylalanine-arginine-tryptophan-NH2, or a pharmacologically acceptable salt, complex or derivative thereof.
- 9. A composition for the treatment of obesity and the control of appetite in a mammal comprising an effective amount of a peptide derivative of claim 1 in combination with a carrier therefore
- 10. A method for the treatment of obesity and control of appetite comprising administering to a mammal in need thereof an effective amount of a peptide derivative according to claim 1.
Government Interests
[0001] The work reported herein was supported by NIH Grant RO1-DK57080. Accordingly, the U.S. Government has certain rights in the invention.