Claims
- 1. A method of inhibiting human immunodeficiency virus infection of host cells and syncytia formation between infected and non-infected cells, comprising administering to said cells an effective amount of a polypeptide having a C-terminal amide group of the molecular formula: ##STR3## wherein X is selected from the group consisting of hydrogen and about one to four additional amino acid residues.
- 2. The method according to claim 1 wherein X is selected from the group consisting of glycine, arginyl-glycine and tyrosyl-arginyl-glycine.
- 3. A composition for inhibiting human immunodeficiency virus infection of host cells and syncytia formation between infected and non-infected cells, comprising an effective amount of a polypeptide having a C-terminal amide group of the molecular formula: ##STR4## wherein X is selected from the group consisting of hydrogen and about one to four additional amino acid residues.
- 4. The composition according to claim 3 wherein X is selected from the group consisting of glycine, arginyl-glycine and tyrosyl-arginyl-glycine.
- 5. The composition according to claim 3 wherein the pharmaceutically acceptable carrier is selected from the group consisting of isotonic saline and isotonic phosphate buffered saline.
- 6. The method of claim 1, wherein X is glycine.
- 7. An isolated peptide having the following molecular formula: ##STR5## wherein X is selected from the group consisting of glycine, arginyl-glycine, tyrosyl-arginyl-glycine.
Parent Case Info
This application is a continuation application of U.S. patent application No. 07/988,127, filed Feb. 12, 1993, now abandoned which is a continuation-in-part of U.S. patent application 07/571,080, filed as PCT/SE91/00544 Aug. 20, 1991, published as WO92/03147 Mar. 5, 1992, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4612337 |
Fox et al. |
Sep 1986 |
|
4818540 |
Chien et al. |
Apr 1989 |
|
5126399 |
Arlinghaus et al. |
Jun 1992 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0267802 |
May 1988 |
EPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
988127 |
Feb 1993 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
571080 |
Aug 1990 |
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