Claims
- 1. A compound of structure (1) ##STR5## wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, CHR.sup.6 CONHR.sup.7 l or CHR.sup.6 COOR.sup.7 in which R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-4 alkyl;
- R.sup.2 is hydrogen, C.sub.1-5 alkyl, C.sub.6 H.sub.5 CH.sub.2, CH.sub.2 OH, CH.sub.2 CH.sub.2 CONH.sub.2 or CH.sub.2 COOH;
- R.sup.3 is hydrogen, C.sub.1-4 alkyl, CONH.sub.2 or CO.sub.2 R.sup.8 in which R.sup.8 is hydrogen, or C.sub.1-4 alkyl, and
- n is 4;
- or a pharmaceutically acceptable salt thereof.
- 2. A compound of structure (1) as claimed in claim 1 in which R.sup.1 to R.sup.3 are each hydrogen.
- 3. The compound according to claim 1 wherein R.sup.2 is hydrogen, or C.sub.1-5 alkyl.
- 4. The compound according to claim 3 wherein R.sup.2 is --CH.sub.3, or --CH(CH.sub.3).sub.2.
- 5. A compound of structure (1) as claimed in claim 1 which is:
- 2,5-dioxo-1H-octahydroimidazo[1,2-a]azepine.
- 6. A pharmaceutical composition comprising a compound of structure (1) or a pharmaceutically acceptable salt thereof as claimed in claim 1 and a pharmaceutically acceptable carrier.
- 7. A pharmaceutical composition according to claim 6 wherein the compound of structure (1) is 2,5-dioxo-1H-octahydroimidazo[1,2-a]azepine.
- 8. A method of restoring learning and treating memory difficulties which comprises administering to a subject in need thereof a non-toxic effective amount of a compound of structure (1) as described in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
19336 A/88 |
Feb 1988 |
ITX |
|
Parent Case Info
This is a division of application Ser. No. 07/669,806 filed Mar. 15, 1991 now U.S. Pat. No. 5,130,319 which is a division of application Ser. No. 07/307,012 filed Feb. 6, 1989 now U.S. Pat. No. 5,053,422.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3334099 |
Houlihan |
Aug 1967 |
|
4582838 |
Butler et al. |
Apr 1986 |
|
4677098 |
Butler et al. |
Jun 1987 |
|
Divisions (2)
|
Number |
Date |
Country |
Parent |
669806 |
Mar 1991 |
|
Parent |
307012 |
Feb 1989 |
|