The following relates generally to photoarray systems, and more particularly to photoarray systems with local sensing.
Light therapy involves administering doses of optical radiation to the body of a recipient of the therapy. Various light therapy systems are known, including those having one or more radiation sources incorporated into a housing that is designed to be held and aimed by a therapist to direct optical radiation towards a patient during a therapy session. Other light therapy systems include a flexible substrate with which is integrated an array of radiation sources. Such flexible photoarray systems are designed to conform to a non-planar portion of the recipient's body thereby to enable the radiation sources to be proximate to a region of interest, such as against the recipient's skin, without having to be constantly held in position by the therapist for the duration of a treatment session.
A physically flexible photoarray system is generally intended to be positioned directly proximate to the body of the recipient of the optical radiation. With such a system, the therapist is not generally able to observe the skin or other body surface of the recipient where it is occluded by the flexible photoarray system. Furthermore, a recipient of the light therapy, typically unfamiliar with the therapy process, may not raise concerns about discomfort or may not even feel discomfort despite heat levels in various areas between the flexible photoarray system and the recipient's body with which it is directly proximate being higher than is healthy for the recipient. Similarly, the therapist and recipient are not typically able to visually gauge whether an effective amount of radiation has been administered to the region of interest.
In addition, it would be useful for a flexible photoarray system to be portable to the extent that it could remain on the recipient, unsupervised by a therapist, for extended periods while the recipient is doing some other activity. However, facilitating portability and unsupervised use raises unique challenges in how each of power management, heat management, treatment duration and dose monitoring and the like are addressed.
According to an aspect, there is provided a photoarray system comprising a control system; a lixel array comprising a plurality of lixels each comprising at least one radiation source that is individually controllable by the control system to emit radiation; and a sensor array comprising a plurality of sensor modules distributed amongst the plurality of radiation sources, each of the sensor modules configured to communicate respective local readings to the control system.
According to another aspect, there is provided a lixel array for a photoarray system having a control system, the lixel array comprising a plurality of lixels, each lixel comprising a platform; at least one radiation source supported on the platform; processing structure supported on the platform and configured to selectively actuate the at least one radiation source in response to instructions from the control system; and a temperature sensor supported on the platform and configured to provide local temperature readings to the processing structure for provision to the control system.
According to another aspect, there is provided a photoarray system comprising a lixel array comprising a plurality of lixels each comprising at least one radiation source and at least one local sensor; and a control system in communication with each of the lixels and operable to individually control emission of radiation from each radiation source based at least on readings of the at least one local sensor.
Other aspects and advantages will become apparent from the following description.
Embodiments will now be described with reference to the appended drawings in which:
The following description relates to photoarray systems, and description is provided of a photoarray system comprising a granularly controllable lixel array having a plurality of lixels each having one or more radiation sources. The lixel array of the photoarray system preferably delivers high power optical energy from the radiation sources in close proximity over a large epidermal surface area on human or animal patients. Providing individual control over each of the plurality of radiation sources facilitates maintaining thermal energy at comfortable levels for a patient, while facilitating efficient delivery of electrically-powered radiation.
In this description, the term “lixel” refers to an electronic module comprising one or more radiation sources for emitting non-ionizing radiation such as visible, infrared and/or ultraviolet light and that is individually controllable to cause its one or more radiation sources to be actuated.
Turning to
In this embodiment, control system A includes a main control module 100 having microcontroller 110, and a radiofrequency transceiver 112 configured to provide wireless data communications with an external computing device 1000 such as a desktop computer, a laptop computer, a Smartphone or a tablet having a similar transceiver and equipped to operate according to standard communications protocols. Such protocols may include WIFI, Bluetooth™, Bluetooth low-energy, ZigBee, ANT, ANT+, MICS, MBAN, MDDS, WMTS, Wireless USB, Z-Wave, 3G, and 4G (LTE) and other hardware/software protocols which may become adopted for short to medium range wireless communications. For example, main control module 100 may be programmed or re-programmed with instructions provided via RF transceiver 112.
Main control module 100 also includes a power section 114, a human/machine interface 116, and a rechargeable battery 118. In this embodiment, human/machine interface 116 includes touch-sensitive controls for actuation and other functions, the operation of which is well known and will not be described further herein.
Main control module 100 also includes a first power/data interface 120 that can be mated with a second power/data interface 220 with which a plurality of communication link modules, or “commlinks” 200 (which are numbered individually as 200_1, 200_2, 200_3 to 200_x in
In this embodiment, the main control module 100 provides power through power/data interface 120 along three (3) electrical lines, namely a fixed voltage line V, (which would typically be fixed at 5 VDC or 3.3 VDC though other fixed voltages can be used), a variable voltage line Vnet, and a ground (GND) line. Furthermore, in this embodiment, main control module provides data communications along two (2) lines forming an I2C (Inter-Integrated Circuit) serial data bus, namely a serial clock line (I2C SCL) and a serial data line (I2C SDA).
In this embodiment, lixel array B includes a plurality of lixels 300, each of which are in power and data communications via the three (3) power lines and the two (2) data lines with a respective commlink 200. In particular, each commlink 200_1 . . . 200_x is in power and data communications with a respective subset of the plurality of lixels 300. As shown in
The number of lixels 300 that are in power and data communications with a respective commlink 200 is not fixed, and may not be the same across all commlinks 200_1 to 200_x. Accordingly, for example, commlink 200_1 may be in power and data communications with one number of lixels 300, and commlink 200_2 may be in power and data communications with a different number of lixels 300.
Stored in the memory devices are temporary data, along with processor-readable instructions, baseline protocols and temporary protocols for operating the photoarray system 10, along with measurement and reading data from lixels 300 as will be described. Processor-readable data embodying a lixel illumination pattern in the form of tables of electrical current values or similar data may also be stored on main control module 100. Other types of microprocessors could be used. Current control, rather than voltage control, is implemented because radiation output of the radiation sources is linear with respect to current running through the radiation sources. Microprocessor 110 is in data communications with other components of the main control module 100, including RF transceiver 112, human-machine interface 116, power section 114 having a fixed voltage regulator 114a, a variable Vnet voltage regulator 114b and a battery charger/Coulomb Counter 114c, rechargeable battery 118, and the first power/data interface 120. Rechargeable battery 118 is in power communications with battery charger/Coulomb counter 114c.
A sensor module 119 for the main control module 100 houses one or more of: an ambient temperature sensor, a motion sensor, a humidity sensor, a physical orientation sensor, an acceleration sensor, an ambient light sensor, a magnetic field sensor, a proximity sensor, an audio level sensor, a video imaging device, an imaging device, one or more colour sensors, or another sensor useful for providing operating and environment data.
First interface 120 of main control module 100 is also connectable to an AC (alternating current) adaptor 2000 via an interface 220A that cooperates with first interface 120 in a similar or the same manner to interface 220, and directs incoming power VCHG from the AC adaptor 2000 to the battery charger/Coulomb counter 114c for charging the rechargeable battery 118. Interface 220A can be configured such that VCHG can be connected to the Vnet pin, or to some other pin.
Each of fixed voltage line Vs and data bus lines I2Cxy is connected to a local microcontroller 210, with fixed voltage line Vs being connected to local microcontroller 210 via a voltage regulator 212. The voltage regulator 212 is used for implementations in which microcontroller 210 has a different, operating voltage than that of microprocessor 310. Microcontroller 210 also includes a separate communications Port I2CL to which is connected a second set of data bus lines for each of I2C SCL and I2C SDA for its respective lixels 300. It will be noted that lines extending from each of Vs, Vnet and GND are run as outputs to commlink 200, with the variable voltage line Vnetf (Vnet “fused”) being run as an output via a fuse 214, and fixed voltage line Vsf (Vs “fused”) being run as an output via a fuse 216.
Microprocessor 310 incorporates multiple internal Field Effect Transistors (FETs) for amplitude control of the current, and a brown-out detector for maintaining reliability in the event of a dip in supply voltage. Microprocessor 310 monitors the voltage and current being provided to radiation sources 312a, 312b and 312c and in addition to accordingly controlling its own levels, can report its local conditions and how it has exercised control to its associated commlink 200. Commlink 200 has electronic storage structure to locally buffer such data. In this way, the main control module 100 can receive information about how many joules of radiation energy were delivered by each lixel 300, and therefore how many total joules of radiation energy total were delivered to the area being illuminated.
In this embodiment, each of radiation sources 312a, 312b and 312c is a high efficiency Light Emitting Diode (LED). Microprocessor 310 monitors the current running through each of the LEDs 312a, 312b and 312c thereby to make adjustments to the current supply so as to maintain a regulated current and therefore a regulated radiation output.
In this embodiment, radiation source 312a is an LED that outputs radiation having a wavelength of about 455 nanometers (nm) (Δλ 25 nm typical), radiation source 312b is an LED that outputs radiation having a wavelength of about 660 nm (Δλ 25 nm typical), and radiation source 312c is an LED that outputs radiation having a wavelength of about 850 nm (Δλ 30 nm typical). The about 455 nm wavelength of radiation is provided with a view to treating bilirubin associated with jaundice and for reducing bacteria contamination in wounds. Furthermore, while visible red having wavelength near to 632 nm has been commonly used from the earliest He—Ne lasers to treat topical wounds and other musculoskeletal conditions, more recently wavelengths between 650 to 670 nm have been commonly used. Manufacturers have been able to create effective strategies in doping semiconductor materials and optical packaging to increase the conversion rate from electrical to optical power.
The about 850 nm wavelength of radiation is provided with a view to achieving deeper penetration into the muscle and circulatory tissues because these are more transparent to the longer wavelength of near-infrared. Wavelengths between 800 and 870 nm approach what is currently considered to be near the optimal window of transmission where red cells and water allow transmission into tissue.
It will be noted that the 455 nm blue wavelength is a higher photonic energy device, and its penetration is low compared to that of the red and near-infrared wavelengths.
Depending upon the instructions sent from main control module 100 via its respective commlink 200, microprocessor 310 of lixel 300 actuates any or all of radiation sources 312a, 312b and 312c. It will be understood that radiation sources 312a, 312b and 312c may require respective, different voltage levels to operate. In this embodiment, the main control module establishes the appropriate voltage level for whichever of radiation sources 312a, 312b and/or 312c by automatically setting the Vnet voltage level to a level appropriate to the radiation source(s) to be activated during a particular treatment regimen, or phase thereof. Because the main control module 100 controls Nnet voltage level in concert with its instructions to commlinks 200 as to which radiation source(s) is/are to be actuated, each lixel 300 does not have to include respective voltage divider components for each radiation source. This configuration can provide cost savings, particularly for larger lixel arrays, and can also reduce the amount of heat that would have to otherwise be dissipated through the lixel array B via step-down resistors.
A therapist may program the microprocessor 110 of the main control module 100 to operate radiation sources 312 on fewer than all lixels 300 in the lixel array B. For example, radiation sources 312 on all lixels 300 of a large lixel array B may not be required, for example in implementations where the photoarray is being used in order to provide phototherapy to a relatively small target area on a patient. Due to the individual addressability of the lixels 300 provided by the configurations described herein, individualized activation and de-activation of the radiation sources 312 is possible such that power can be preserved more readily than photoarray systems that do not provide individual addressability.
In this embodiment, actuation of each radiation source on each lixel 300 is controlled by the main control module 100 providing instructions to each of the commlinks 200 to begin a timed sequence of messaging with the individual lixels 300 to actuate one or more of its radiation sources 312 in accordance with a protocol. The radiation sources 312 may be cycled ON and OFF in a predefined manner so as to prevent generating sudden electrical transients which can cause noise in the photoarray system 100 itself due to electromagnetic interference (EMI), or in nearby devices. For example, power to radiation sources 312 can be tailored as a sinusoidal or linear ramped increase to the desired holding level and then decreased similarly back to fully off. The ability to reduce the intensity or rapidly modulate the output is also a mechanism for controlling the temperature by reducing the average ON time of the radiation source 312. Pseudo random modulation, such as is provided by stochastic signal density modulation, an example of which is a technology provided by Cypress Semiconductor known as Precision Illumination Signal Modulation (PrISM), or pulse width modulation (PWM) may be employed to achieve this. As would be understood, an LED driven below 100 milliAmperes (mA) will not provide reliable or any radiation output. For example, in the event that the equivalent of 50 mA worth of radiation is desired for a particular treatment or treatment phase, the LED is driven at 100 mA but modulated at an averaged 50% duty cycle so as to produce the radiation to compensate for the operating characteristics and produce output as though it were being steadily operated at 100% duty cycle at half of 100 mA (i.e. 50 mA). Above this point the duty cycle can be adjusted until 100% duty cycle is reached at the 100 mA level, and then the actual current level can be increased to produce increases in the radiation output. In general, the relationship between current and radiation output is linear above this point and within a range, such that 200 mA of current will produce twice the light of 100 mA. This is effectively the PRISM technology being used within the PSoC (Programmable System on Chip), which is implemented as a FET current driver of LEDs with programmable tables stored therein.
Such individualized control provided by the photoarray system 10 described herein allows for a balanced or increased thermal conduction rate to the lower ambient temperature at a heat sink side of the lixel which prevents an increase in temperature on the patient side of the device.
Also connected to microprocessor 310 of lixel 300 is a temperature sensor, in this embodiment a thermistor 314, and a photo sensor, in this embodiment a photodiode 316. Thermistor 314 provides microprocessor 310 with a reading of the ambient temperature level local to the lixel 300. Similarly, photodiode 316 provides microprocessor 310 with a reading of the ambient radiation intensity level local to the lixel 300. One or more additional sensors 326 may be provided in order to sense ambient motion, humidity, physical orientation, acceleration, magnetic field, proximity, audio level, video, images, one or more colours, or other ambient physical quantities for providing operating and environment data. The provision of such sensors in association with each or some lixels 300 enables the sensors to be distributed amongst the radiation sources. In this embodiment, as each lixel 300 includes sensors, the sensors are distributed generally uniformly amongst the lixels 300. Other configurations for distributing sensors generally uniformly amongst the radiation sources, such as for example by providing only every second lixel 300 with one or more such sensors, or for providing one type of sensor on one lixel 300 and another type of sensor on the next lixel 300, and so forth, are possible. Other configurations including non-uniform distribution of sensors amongst the radiation sources 300 may be employed in particular implementations.
Because sensors 314, 316 and 326 are local to lixel 300, microprocessor 310 is able to communicate local temperature and radiation intensity readings to a respective commlink 200 when polled by the commlink 200 to collect and store the readings for each of the subset of the plurality of lixels 300 with which it is associated. Such polling may be initiated by the main control module 100, so as to collect local readings for restructuring and/or buffering at respective commlinks 200 for subsequent provision to main control module 100 and to, in turn, modify actuation of any or all radiation sources 312 of any or all lixels 300 in the lixel array B should local radiation intensity be too high or too low, or should local temperature be too high, for example. In this manner, high-resolution temperature and intensity feedback is available to the main control module 100 so that it may, in turn, modify the sequencing and/or provide granular control over the operation of each individual radiation source 312 in order to provide heat management and to accurately determine the amount of radiation actually being delivered to a patient More particularly, it is preferred that maximum temperature at a particular location in the lixel array B be 45° C. or lower. Furthermore, such local readings collected in this way, along with any automatic modifications in operation by lixel 300 or main control module 100 may be stored and/or compressed and/or made available in raw or pre-processed form to a therapist or other user via the human-machine interface 116, or output via RF transceiver 112 to external computing device 1000 for further processing or data collection.
The multiple-tier structure provided by main control module 100, commlinks 200 and lixels 300 further facilitate efficient field-upgrades of the firmware on lixels 300. The main control module 100 can update the firmware on a commlink 200 and then instruct the commlink 200 to, in turn, handle upgrading the firmware on its respective lixels 300. In particular, the main control module 100 does not have to remain occupied updating firmware on individual lixels 300 as it has delegated this task to its commlinks 200.
Turning now to
A heat transfer structure, in this embodiment a heat sink 320, also extends from the side of the platform 318 opposite the patient-facing side for drawing heat away from the patient-facing side of the platform 318.
In an alternative embodiment, an additional control strip is provided and configured with respect to the lixels 300 to limit the degree of convex movement that is permitted, so as to limit the stress placed upon power and data lines, the IDCs and other components that may otherwise occur if the power and data lines are permitted to easily become taut during convex flexing.
Although embodiments have been described with reference to the drawings, those of skill in the art will appreciate that variations and modifications may be made without departing from the spirit and scope thereof as defined by the appended claims.
For example, other local conditions beyond temperature and radiation intensity can be measured by sensors associated with a given lixel, such as current, voltage, orientation, acceleration, gyroscopic, ambient light, magnetic field, proximity, audio level, video image and colour.
Furthermore, while a photoarray system has been described herein that includes a main control module 100, a plurality of commlinks 200 and a plurality of lixels 300, other configurations are possible. For example, the three-level hierarchy could be reduced to two levels (i.e., main control module 100 and respective lixels 300), provided that semiconductors are employed that can reliably communicate over a short range (0.1 to 3 meters) communication channel at high speed (125 kbit to 12 Mb or faster).
Furthermore, while embodiments have been described in which each lixel 300 controls the power directly to the local radiation sources 312a, 312b and 312c, embodiments are contemplated in which an alternative lixel structure having a microprocessor 310 is capable of controlling one or more adjacent lixels that may not have a respective microprocessor.
While embodiments have been described in which the lixels 300 have three radiation sources that are LEDs, embodiments are contemplated in which lixels have fewer or more radiation sources, emit different wavelengths of light than those that have been described by way of example herein (such as ultraviolet radiation, violet radiation, other visible or infrared radiation) and those in which the radiation sources are other or various types of radiation sources such as solid state laser diodes, OLEDs (Organic Light Emitting Diodes), or FIPEL (Field-induced polymer electroluminescent) radiation sources, with corresponding respective operating characteristics and supporting circuitry, for example.
Furthermore, while in embodiments described an aluminum block heat sink 320 has been shown as part of lixel 300, other configurations are contemplated. For example, due to the open-backed nature of the lixel 300, where lines for Vsf, Vnetf, GND, I2C SCL and I2C SDA run along the sides of the underside of the platform 318 rather than across the middle of platform 318, adequate heat dispersion may be provided without a heat sink.
Furthermore, other embodiments of heat sink may employ a rectangular block or a block with a cutaway portion having a rectangular, oval or circular cross-section for receiving a heat conveyance structure such as a rigid or flexible heat pipe that can convey heat away from several lixels 300 in a row. Flexible phase change material or materials may be employed to assist with drawing heat away from the patient-facing side of the lixel 300. Additional or auxiliary cooling systems may be provided.
Furthermore, while platform 318 has been described as hexagonal-shaped printed circuit board, other shapes such as square, circular or irregular-shaped platforms may be employed.
While microprocessors 110, 210 and 310 operating at 5V are employed in the embodiments described above, alternatives are possible. For example, microprocessors that operate at 3.3V or lower could be employed.
Furthermore, while embodiments have been described in which each lixel incorporates a temperature sensor and a radiation sensor, variations are possible. For example, every other or third lixel could be provided with one or both such sensors. It will be understood however that local temperature and radiation intensity can vary widely across short distances due to the physical attributes of the patient, clothing, adjacency, and effectiveness of local heat sinking.
Furthermore, while the main control module in embodiments described above provides data communications along a two-line I2C serial data bus, an alternative data communications scheme may be employed, such as LINbus (Local Interconnect Network bus), 1-Wire or some other widely available or proprietary bus technology.
Furthermore, an alternative embodiment of a lixel array B could incorporate a wireless communication link for very short range and a wireless power transfer scheme such as WiTricity or Qi to accomplish the same individual control of each lixel without the hardwired links for even greater flexibility limited only by the typical range of the wireless power transfer.
Furthermore, an alternative embodiment of a lixel array B could include sensors 326 dispersed at relevant locations throughout the lixel array B. For example, for wound monitoring, a photoarray system for use in phototherapy could be provided with colour sensors distributed throughout the lixel array B in such a way as to have colour sensing both peripherally and centrally with respect to a wound being treated. Emission of radiation from particular radiation sources 312 could be used to cause the wound area to, in turn, emit radiation depending upon its healing state, such that the data collected by the colour sensors could show rate and progress of the healing.
This application claims priority to U.S. Provisional Patent Application Ser. No. 61/931,771 filed on Jan. 27, 2014, the contents of which are incorporated entirely herein by reference.
Filing Document | Filing Date | Country | Kind |
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PCT/CA2015/000097 | 1/26/2015 | WO | 00 |
Number | Date | Country | |
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61931771 | Jan 2014 | US |