Claims
- 1. A peptide having the formula
- A.sub.1 --D.sup..beta. Nal--A.sub.3 --Trp--A.sub.5 --A.sub.6 --Z,
- wherein A.sub.1 is His, 3(NMe)His, His--Ala, Ala, Tyr, A.sub.0 --His or A.sub.0 --3(NMe)His, where A.sub.0 is Ala, Lys, or Glu Met(O), DOPA, Abu or peptides of the formula L--A.sub.0, wherein L is H, DOPA, Lys, Phe, Tyr, Cys, Tyr--DAla--Phe--Gly, Tyr--DAla--Gly--Phe, Tyr--Ala--Gly--Thr or Tyr--DAla--Phe--Sar;
- A.sub.3 is Ala, Gly or Ser;
- A.sub.5 is DPhe, D/L.sup..beta. (Me)Phe or (NMe)DPhe;
- A.sub.6 is Arg, iLys, Lys or Orn;
- Z is NH.sub.2 ;
- and organic or inorganic pharmaceutically acceptable salts thereof.
- 2. The peptide according to claim 1, wherein A.sub.1 is His, Ala, His--Ala or A.sub.0 --His.
- 3. The peptide according to claim 1, wherein A.sub.0 is Ala, Lys, or Glu; A.sub.3 is Ala; A.sub.6 is Lys, or iLys.
- 4. The peptide according to claim 1, wherein A.sub.3 is Ala.
- 5. The peptide according to claim 1 having the formula His--D.sup..beta. Nal--Ala--Trp--DPhe--A.sub.6 --Z.
- 6. The peptide according to claim 1 having the formula A.sub.0 --His--D.sup..beta. Nal--Ala--Trp--DPhe--A.sub.6 --Z.
- 7. The peptide according to claim 1 having the formula Lys--His--D.sup..beta. Nal--Ala--Trp--DPhe--A.sub.6 --NH.sub.2.
- 8. The peptide according to claim 1 having the formula Glu--His--D.sup..beta. Nal--Ala--Trp--DPhe--A.sub.6 --NH.sub.2.
- 9. The peptide according to claim 1 having the formula His--Ala--D.sup..beta. Nal--Ala--Trp--DPhe--A.sub.6 --Z.
- 10. The peptide according to claim 1 having the formula His--Ala--D.sup..beta. Nal--Ala--Trp--DPhe--Lys--NH.sub.2.
- 11. The peptide according to claim 1 having the formula Ala--D.sup..beta. Nal--Ala--Trp--DPhe--A.sub.6 --Z.
- 12. The peptide according to claim 1 having the formula Ala--D.sup..beta. Nal--Ala--Trp--DPhe--Lys--NH.sub.2.
- 13. The peptide having the formula His--D.sup..beta. Nal--Ala--Trp--DPhe--Lys--NH.sub.2.
- 14. The peptide having the formula Ala--His--D.sup..beta. Nal--Ala--Trp--DPhe--Lys--NH.sub.2.
- 15. A peptide having the formula Ala--His--D.sup..beta. Nal--Ala--Trp--DPhe--Ala--Lys--NH.sub.2.
- 16. A peptide having the formula Ala--His--D.sup..beta. Nal--Ala--Trp--DPhe--Ala--Ala--Lys--NH.sub.2.
- 17. A method of promoting the release of growth hormone levels in an animal comprising administering to the animal an effective amount of at least one of the peptides of claims 1, 4, 5, 6, 9, 11, 13, 14 or 15.
- 18. The method of claim 17, wherein the animal is a mammal.
- 19. The method of claim 17, wherein the animal is a human.
- 20. A pharmaceutical composition for promoting the release of growth hormone levels in animals comprising at least one of the peptides of claim 1, 3, 5, 6, 9, 11, 13, 14 or 15 and a pharmaceutically acceptable carrier or diluent.
- 21. The pharmaceutical compositions of claim 20, which further comprises a second compound, wherein said second compound is a Group 1 or Group 3 compound.
- 22. The pharmaceutical composition of claim 21, wherein the second compound is Tyr--Ala--Asp--Ala--Ile--Phe--Thr--Asn--Ser--Tyr--Arg --Lys--Val--Leu--Gly--Gln--Leu--Ser--Ala--Arg--Lys--Leu--Leu--Gln--Asp--Ile--Nle --Ser--Arg--NH.sub.2, or Tyr--DArg--Phe--Gly--NH.sub.2.
- 23. A method of promoting the release and elevation of blood growth hormone levels by administering the peptide of claim 1 in an effective amount with a second compound, wherein said second compound is a Group 1 or Group 3 compound.
- 24. The method of claim 23, wherein the second compound is Tyr--Ala--Asp--Ala--Ile--Phe--Thr--Asn--Ser--Tyr--Arg--Lys--Val--Leu--Gly--Gln --Leu--Ser--Ala--Arg--Lys--Leu--Leu--Gln--Asp--Ile--Nle--Ser--Arg--NH.sub.2, or Tyr --DArg--Phe--Gly--NH.sub.2.
Parent Case Info
This is a continuation of application Ser. No. 07/557,226 filed on Jul. 24, 1990, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0018072 |
Oct 1980 |
EPX |
WO8706835 |
Nov 1987 |
WOX |
WO8909780 |
Dec 1988 |
WOX |
WO8907110 |
Aug 1989 |
WOX |
WO8907111 |
Aug 1989 |
WOX |
WO8910933 |
Nov 1989 |
WOX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
557226 |
Jul 1990 |
|