Claims
- 1. A polypeptide derived from human mature granulocyte colony stimulating factor (hG-CSF) polypeptide, wherein the derivative differs from the hG-CSF of Table 1 by deletion of one or more amino acid residues in the 11 N-terminal amino acid region and, optionally by substitution of the Cys at position 17 to Ser.
- 2. The polypeptides according to claim 1, wherein a peptide in the 1st to 4th, 1st to 5th, 1st to 6th, 1st to 7th or 1st to 11th amino acids on the N terminus portion of the hG-CSF polypeptide is deleted.
- 3. The polypeptide according to claim 1, wherein, in addition to amino acid deletion, the 17th amino acid cystein (Cys) of the hG-CSF polypeptide has been replaced by serine (Ser).
Priority Claims (3)
Number |
Date |
Country |
Kind |
61-306799 |
Dec 1986 |
JPX |
|
63-51357 |
Mar 1988 |
JPX |
|
63-80088 |
Mar 1988 |
JPX |
|
Parent Case Info
This is a division of application Ser. No. 08/274,433, filed Jul. 13, 1994 which is a division of Ser. No. 07/994,924 filed Dec. 22, 1992, now U.S. Pat. No. 5,362,853 which is a division of Ser. No. 07/337,002 filed Apr. 12, 1989 Now U.S. Pat. No. 5,214,132 which is a continuation-in-part of Ser. No. 07/318,527 filed Mar. 3, 1989 now U.S. Pat. No. 5,194,592 which is a continuation-in-part of Ser. No. 07/136,647 filed Dec. 22, 1987, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (2)
Number |
Date |
Country |
6 243 153 |
Oct 1987 |
EPX |
0 256 843 |
Feb 1988 |
EPX |
Non-Patent Literature Citations (5)
Entry |
Ayala et al. 1980, Modern Genetics, Benjamin/Cummings Publishing Co., Menlo Park, CA, pp. 45-48. |
Ngo et al. 1994, The Protein Folding Problem & Tertiary Structure Prediction, Merz et al., eds, Birkhauser, Boston, pp. 491-495. |
Bowie et al. 1990, Science 247:1306-10. |
Wills et al, Gene 34 1955, pp. 315-323. |
Zoller et al, Nucleic Acids Res20(10):1982, pp 6487-8100. |
Divisions (3)
|
Number |
Date |
Country |
Parent |
274433 |
Jul 1994 |
|
Parent |
994924 |
Dec 1992 |
|
Parent |
337002 |
Apr 1989 |
|
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
318527 |
Mar 1989 |
|
Parent |
136647 |
Dec 1987 |
|