Claims
- 1. The method of preparing in dry powder form a therapeutic pancreatin composition having proteolytic, amylolytic and lipolytic activity which comprises adding to comminuted pork or beef pancreas with thorough mixing an aqueous medium containing calcium sulfate in an amount between 0.02% and 1.4% based upon the weight of comminuted pancreas, said aqueous medium incorporating added water in an amount up to about 5.5%, based upon the weight of comminuted pancreas, admixing proteolytic enzyme for trypsinogen and chymotrypsinogen selected from the group consisting of pork duodenum and trypsin in the pancreas whereby proteolytic activity is established, maintaining said admixture at a temperature of about 32.degree.F. to 80.degree.F. until activation is complete, washing said admixture with acetone and heating said washed admixture to a temperature in the range between 120.degree.F. and 180.degree.F. whereby the admixture is dehydrated and susceptible pathogenic bacteria are inactivated.
- 2. The method of preparing in dry powder form a therapeutic pancreatin composition having proteolytic, amlolytic and lipolytic activity which comprises adding to comminuted beef or pork pancreas with thorough mixing an aqueous medium containing an inorganic salt selected from the group consisting of calcium sulfate and calcium acetate in an amount between 0.02% and 1.4% based upon the weight of comminuted pancreas, said aqueous medium incorporating added water in an amount up to about 5.5% based upon the weight of comminuted pancreas, admixing comminuted pork duodenum with said pancreas mixture in an amount of about 10% based upon the weight of comminuted pancreas, maintaining said admixture at a temperature of about 32.degree.F. to 80.degree.F. until activation is complete, washing said admixture with acetone, heating said washed admixture to a temperature in the range between 120.degree.F. and 180.degree.F. whereby the admixture is dehydrated and susceptible pathogenic bacteria are inactivated.
- 3. A method according to claim 1 wherein said activator is active trypsin.
- 4. A dry powdered therapeutic composition free of pathogenic bacteria and having proteolytic, amylolytic and lipolytic activity prepared by the process of claim 1.
Parent Case Info
This application is a continuation of application Ser. No. 770,443, filed Oct. 24, 1968, now abandoned, entitled PANCREATIN COMPOSITION AND METHOD OF PREPARATION, now
US Referenced Citations (4)
Non-Patent Literature Citations (1)
Entry |
Wilson et al., Textbook of Organic Medicinal and Pharmaceutical Chemistry, 1962, 4th Edition, pp. 762-764. |
Continuations (1)
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Number |
Date |
Country |
Parent |
770443 |
Oct 1968 |
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