Claims
- 1. The method of producing antibiotic A-51568, which has the structure ##STR3## and its pharmaceutically-acceptable, non-toxic salts, which comprises (1) cultivating Nocardia orientalis NRRL 15232, or an A-51568-producing mutant or variant thereof, in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced, (2) isolating the mixture of A-51568 and A-51568B from the culture medium and (3) isolating A-51568 from the mixture of A-51568 and A-51568B.
- 2. A biologically pure culture of Nocardia orientalis NRRL 15232.
CROSS REFERENCE TO RELATED APPLICATION
This is a continuation-in-part of co-pending application Ser. No. 450,880, filed Dec. 20, 1982, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0765886 |
Jan 1957 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Williamsom et al., "Structure Revision of the Antibiotic Vancomycin. The Use of Nuclear Overhauser Effect Difference Spectroscopy", J. Am. Chem. Soc. 103, 6580-6585 (1981). |
Kalman et al., "An NMR Study of the Antibiotic Ristocetin A. The Negative Nuclear Overhauser Effect in Structure Elucidation" J. Am. Chem. Soc. 102, 897-905 (1980). |
Ellestad et al., "Avoparcin and Epiavoparcin", J. Am. Chem. Soc. 103, 6522-6524 (1981). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
450880 |
Dec 1982 |
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