Claims
- 1. A method for separating phenylalanine from a fermentation feed comprising phenylalanine, salts, carbohydrates, amino acids and organic acids, comprising contacting said feed, while maintaining said feed at a pH of about 4.5 to about 6.5, with a hydrophobic, porous synthetic adsorbent having functional groups whose dipole moment is from 1.6 to 2.0, a surface area of 140 to 450 m.sup.2 /g, an average pore diameter of 80 to 235 Angstroms and a porosity of 0.5 to 0.55 ml/g, comprising a macroporous acrylic ester polymer, adsorbing said phenylalanine onto said adsorbent, removing said other feed components from contact with said adsorbent as raffinate, and desorbing said phenylalanine at desorption conditions with a desorbent comprising water, an alcohol, a ketone or an ester.
- 2. The method of claim 1 wherein said adsorbent is a crosslinked, macroporous acrylic ester copolymer.
- 3. The method of claim 2 wherein the crosslinking comonomer is trimethylolpropane trimethacrylate.
- 4. The method of claim 1 wherein said adsorbent is a crosslinked acrylic ester homopolymer.
- 5. The method of claim 4 wherein the monomer from which said homopolymer is derived is trimethylolpropane trimethacrylate.
- 6. The method of claim 1 wherein said desorption conditions comprise temperatures within the range of 40.degree. to 90.degree. C.
- 7. The method of claim 1 wherein said pH is about 6.
- 8. The method of claim 1 wherein the concentration of salts in said feed is less than about 0.1N.
- 9. The method of claim 1 wherein the concentration of salts in said feed is less than about 0.5N.
- 10. The method of claim 1 wherein the dipole moment of the functional groups of said adsorbent is 1.8.
- 11. The method of claim 10 wherein the desorbent is water.
- 12. The method of claim 1 wherein said adsorbent has a surface area of about 450 m.sup.2 /g, an average pore diameter of about 80 Angstroms, and a porosity of about 0.5 to 0.55 ml/g.
Parent Case Info
This is a continuation of copending application Ser. No. 07/380,921 filed on July 17, 1989, which, in turn, is a continuation-in-part of U.S. Ser. No. 260,105, filed Oct. 20, 1988, both now abandoned.
US Referenced Citations (11)
Non-Patent Literature Citations (2)
Entry |
Summary Bulletin--Amberlite Polymeric Adsorbents, Rohm & Haas (11 pages), 1978. |
Preliminary Technical Notes--Amberlite.RTM. XAD-7 , Rohm & Haas (13 pages) 1978. |
Continuations (1)
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Number |
Date |
Country |
Parent |
380921 |
Jul 1989 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
260105 |
Oct 1988 |
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