Claims
- 1. A process for preparing crystalline TACA ##STR9## which comprises the steps of: reacting 7-aminocephalosporanic acid with 20mercapto-4-methyl-5-carboxymethyl-1,3-thiazole in the presence of a base to form a solution of TACA,
- adding the TACA solution to less than one equivalent of an acid to initiate precipitation of the TACA from the solution, and
- completing precipitation by adding additional acid.
- 2. The process of claim 1, wherein the step of completing precipitation further includes adjusting the pH to a range of 3.0-4.5.
- 3. The process of claim 1, wherein the precipitation is completed by holding the pH constant and adding TACA solution with the additional acid.
- 4. The process of claim 1, further comprising the use of a precipitation auxiliary in the adding step.
- 5. The process of claim 4, wherein the precipitation auxiliary comprises an alcohol.
- 6. The process of claim 5, wherein the alcohol is n-butanol or amyl alcohol.
- 7. The process of claim 1, wherein the TACA solution is an eluate obtained from an absorption resin.
- 8. The process of claim 1, wherein the amount of acid ranges from 0.4-0.5 equivalents.
- 9. The process of claim 1, wherein the acid is an organic or inorganic acid.
- 10. The process of claim 9, wherein the inorganic acid is hydrochloric or sulfuric acid and the organic acid is formic or acetic acid.
- 11. The process of claim 2, wherein the pH is adjusted to a range from about 3.8-4.2.
- 12. The process of claim 1, further comprising centrifuging the crystalline TACA to form a crystal cake, washing the crystal cake of TACA, and centrifugally drying the washed crystal cake.
Priority Claims (1)
Number |
Date |
Country |
Kind |
40 26 630.3 |
Aug 1990 |
DEX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/869,194, filed Apr. 14, 1992, now abandoned, which was a continuation of application Ser. No. 07/747,992, filed Aug. 21, 1991, abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4376200 |
Ozasa et al. |
Mar 1983 |
|
5126445 |
Martin |
Jun 1992 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
869194 |
Apr 1992 |
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Parent |
747992 |
Aug 1991 |
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