Claims
- 1. A process for the preparation of sterile sodium amoxycillin comprising reacting a stable solution of amoxycillin trihydrate in a mixture of methyl alcohol and a lower C.sub.2 C.sub.5 alcohol under sterile conditions with a solution of a suitable salifying agent selected from the group consisting of an alcoholate and carboxylate of sodium in methyl acetate, and separating the resulting precipitate.
- 2. The process of claim 1, wherein the lower C.sub.2 C.sub.5 alcohol is isopropanol.
- 3. The process of claim 1, wherein the reacting step is carried out in the presence of a suitable amine.
- 4. The process of claim 3, wherein the suitable amine is selected from the group consisting of triethylamine and diethylamine.
- 5. The process of claim 1, wherein the salifying agent is sodium 2-ethyl hexanoate.
- 6. The process of claim 3, wherein the solution of amoxycillin trihydrate and the suitable amine in the mixture of methanol and lower C.sub.2 C.sub.5 alcohol undergoes a sterile filtration before being added to the solution of the salifying agent in methyl acetate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
MI92A2296 |
Oct 1992 |
ITX |
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Parent Case Info
This application is a continuation of Ser. No. 08/130,969, filed Oct. 4, 1993, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3192198 |
Nayler et al. |
Jun 1965 |
|
4387051 |
Corbett et al. |
Jul 1983 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0131147 |
Jan 1985 |
EPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
130969 |
Oct 1993 |
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