Claims
- 1. A process for preparing a membrane which binds low density lipoprotein cholesterol comprising
- (a) preparing a hollow fiber membrane from a casting solution comprising about 8 to about 22 weight % of a polysulfone polymer and 0 to about 10 weight % silica;
- (b) submerging said hollow fiber membrane in an acidic solution comprising polyacrylic acid and 0 to about 30 weight % calcium chloride;
- (c) immobilizing polyacrylic acid to said hollow fiber membrane by heating under pressure the submerged fibers of step (b); and
- (d) annealing the hollow fiber membrane of step (c) by heating under pressure in water.
- 2. The process of claim 1 wherein the acidic solution of step (c) is in the pH range of about 1.5 to 5.5.
- 3. The process of claim 1 wherein the submerged membrane is vacuum degassed between step (b) and step (c).
- 4. The process of claim 1 wherein the submerged membrane is vacuum degassed between step (c) and step (d).
- 5. The process of claim 1 wherein the membrane is soaked in a basic solution between step (a) and step (b).
- 6. The process of claim 1 which further comprises the following steps:
- (e) adjusting the solution of step (d) to a pH in the range of 7.5 to 10.5; and
- (f) drying the membrane in the presence of a simple salt and a surfactant.
- 7. The process of claim 1 wherein said silica is present in amounts of about 0.1 to about 10 weight %.
- 8. The process of claim 1 wherein said calcium chloride is present in amounts of about 0.1 to about 3 weight %.
Parent Case Info
This is a continuation-in-part of copending U.S. Ser. No. 782,348, filed Oct. 31, 1991, which is a continuation-in-part of copending U.S. Ser. No. 618,791, filed Nov. 27, 1990, now U.S. Pat. No. 5,187,010.
Non-Patent Literature Citations (2)
Entry |
English Translation of Japanese Reference 63-232845 (published Sep. 1988). |
English Translation of Japanese Reference 1-229878 (published Sep. 1988). |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
782348 |
Oct 1991 |
|
Parent |
618791 |
Nov 1990 |
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