The invention relates to a process of manufacturing an X-ray imaging device and to an X-ray imaging device produced by such a process.
X-ray imaging is conventionally performed by registering an effect produced by an X-ray conversion layer as a function of position. For example, when a scintillation layer is used as X-ray conversion layer, the cumulative intensity of the light produced by the scintillation layer is registered as a function of position. When an X-ray to charge X-ray conversion layer is used, cumulative charge produced by the layer is registered. The effect of the X-rays can be registered by means of an electro-optical detector array or charge detector array on a glass plate or other substrate, with the X-ray conversion layer on top of the electro-optical detector array or charge detector array, deposited by e.g. lamination using an adhesive. To supply and/or receive electronic signal to and/or from the detector array electronic circuits are used. The circuits are peripheral electronic circuits in the sense that they are located outside the detector array in its periphery next to the array, as seen in the direction perpendicular to the image plane defined by the array. The peripheral electronic circuits are located on the substrate next to the X-ray conversion layer, e.g. integrated in an integrated circuit on the substrate.
Earlier X-ray imaging made use of a photographic film instead of an electro-optical detector array to register the image. The use of an electro-optical detector array has the obvious advantage that it does not require a development step of the photographic film and that the image is immediately available for electronic storage, display and processing. However, in other aspects the use of an electro-optical detector array on a glass plate is less convenient than a photographic film. For example, in medical applications it may be more cumbersome to place the device in the desired position relative to a patient because the glass plate is stiff and heavy.
In more complicated X-ray detection devices a plurality of X-ray conversion layers are stacked. Stacking may be useful to realize multi spectral X-ray detection for example. In stacked devices it is a problem that stacking of X-ray conversion layers can lead to damage to layers that include detectors.
KR20160054102 discloses a thin film transistor array panel for digital x-ray detector. A digital X-ray detector is described that includes a thin film transistor array, and peripheral circuits such as a readout circuit unit. The array contains pixels, each with a photodiode that detects X-rays and a multi-layer thin film transistor to connect the photodiode to a data line under control of a gate line. The stiffness of the transistor array is determined by a transistor array substrate. The thin film transistors within the array are located on a buffer layer on the substrate. The peripheral circuits are located one four sides of the transistor array.
US2019179039 discloses use of peripheral circuits in the form of integrated circuit on an external substrate connected to a TFT array or over the TFT array. US2019179039 discloses an improvement of a prior art X-ray detector with a glass substrate with a thin film transistor layer, a PIN diode layer and a scintillator layer disposed over the PIN diode layer.
US2019179039 notes increasing demand for a flexible digital X-ray detector wherein the glass substrate is not used. A flexible digital X-ray detector panel without a base substrate is disclosed, including multi-buffer layer as the lowest layer of the panel, such that the entire thickness of the panel is reduced and flexibility can be more effectively allocated to the panel. The multi-buffer layer does not have a separate base substrate. The scintillator layer serves as a support substrate to provide rigidity to maintain the overall shape of the panel. A protective layer covers the scintillator layer and the device array layer at the scintillator layer 260, such that the scintillator layer has a stronger supporting force.
US2019179039 discloses a method of manufacturing such a device on a sacrificial layer over a sacrificial substrate such as a glass substrate. The multi-buffer layer is stacked over the sacrificial layer, to form a device array layer with thin film transistors 2 and PIN diodes over the multi-buffer layer, and to forming the scintillator layer over the device array layer. Afterwards, the sacrificial layer and the multi-buffer layer are separated, e.g. by laser lift off.
Among others, it is an object to provide for a way of manufacturing a more convenient X-ray imaging device. An optional further object is to reduce the risk of damage when stacking is used.
A method of manufacturing an X-ray imaging device is provided, which comprises
The substrate plate may be a glass plate for example. The further layer may consist entirely of the X-ray conversion area, or comprise another material of similar stiffness laterally adjacent to the area. Problems due to differences in stiffness of the flexible carrier layer and the layer that comprises the X-ray conversion area, such as a scintillator layer or an X-ray to charge conversion layer can be avoided and a flexible X-ray imaging device is obtained that can be fitted into place for use.
Preferably, a ratio of the stiffness of the flexible carrier layer and the stiffness of the further layer has a value so that the stiffness of the X-ray imaging device is substantially determined by the stiffness of the further layer (substantially means e.g. that the X-ray imaging device is less than 101% of the stiffness of the further layer on its own). The stiffness of the further layer is mainly determined by the stiffness of the X-ray conversion layer. This reduces the risk of damage to the array of detector cells sand allows bending the X-ray imaging device into place e.g. for medical use.
In an embodiment, the further layer extends over the entirety of the flexible carrier layer. The further layer may even extend beyond the flexible carrier layer. This prevents stress due to free bending of the flexible layer.
In an embodiment, the further layer consists of the X-ray conversion layer. In another embodiment, the further layer comprises a layer part that is not an X-ray conversion layer outside the area above the array of detector cells. The X-ray conversion layer covers the array of detector cells and is attached to the array of detector cells. The X-ray conversion layer and the layer part may be laterally adjacent to each other in the sense that, together, they form a layer wherein the X-ray conversion layer and the layer part cover different areas below that layer. In the embodiment with a layer part that is not of the material of the X-ray conversion layer, the layer part preferably surrounds the X-ray conversion layer in all lateral directions. Preferably the layer part and the X-ray conversion layer have similar stiffness (e.g. not different by more than a factor two).The layer part may be laminated to the substrate with an adhesive.
An X-ray imaging device manufactured using the steps of any of the preceding claims comprising a flexible carrier layer and a further layer comprising an X-ray conversion layer, wherein the stiffness of the X-ray imaging device is substantially determined by the flexible carrier layer and the X-ray conversion layer, with an array of detector cells and a peripheral circuit electrically interconnected to the detector cells on the flexible carrier layer, wherein the further layer is attached to the flexible carrier layer beyond first and second, mutually opposite edges of the array of detector cells, and beyond the peripheral circuit, the further layer comprising a recess or and opening to accommodate the peripheral circuit.
These and other objects and advantageous aspects will become apparent from a description of exemplary embodiments with reference to the following figures.
In a first step 11 a rigid substrate plate such as a glass plate 20 is provided. In a second step 12 a flexible carrier layer 21 is laminated to or deposited on glass plate 20, as shown in
A layer of a release agent (not shown) may be provided between flexible carrier layer 21 and glass plate 20. By way of reference a direction along flexible carrier layer 21 is indicated as the x direction and the direction perpendicular to flexible carrier layer 21 is indicated as the z-direction.
A third step 13 stands for a number of sub-steps wherein an array of detector cells 22 and its associated wiring is created on flexible carrier layer 21.
The gate of TFT access transistor 104 is coupled to a gate line G. In operation of detector cell 22, photo diode 100 generates electric current in response to incoming light, which charges capacitor 102. In response to a selection signal on gate line G the charge is transferred to the date line.
When an X-ray to charge conversion based imaging device is manufactured, photo diode 100 may be omitted and an electrode may be provided on top of the X-ray to charge conversion layer instead of on the semi-conductor layer that forms the photo diode in the electro -optic embodiment. Thus capacitor 102 is formed between the latter electrode and the electrode that is connected to the channel of transistor 104, with the X-ray to charge conversion layer in between. In this embodiment the detector cells 22 on flexible layer 21 comprise the transistor 104 and the plate electrode that is connected to transistor 104, but not the X-ray to charge conversion layer and the electrode on top of the X-ray to charge conversion layer.
Sub-steps for creating an array of detector cells 22 and its associated wiring are known per se, e.g. from G. Gelinck et al “X-ray detector-on-plastic with high sensitivity using low cost, solution-processed organic photodiodes”. IEEE Transactions on Electron Devices, 63(1), 197-204 (2016). A.R. Cowen, S.M. Kengyelics, A.G. Davies, Clinical Radiology (2008) 63, 487e498 also describe such detectors. TFT transistors can be realized on a flexible layer, which makes it possible for the array of detector cells to conform to bending of the X-ray conversion layer and keeps the detector cell array very thin. Preferably, the flexible layer 21 on which the array of detector cells 22 is located does not extend laterally beyond the X-ray conversion layer. This reduces the risk of damage.
In a fourth step 14 a peripheral circuit 23 is placed on flexible carrier layer 21 outside array of detector cells 22 and next to it, as seen in the direction perpendicular to the image plane, on the peripheral area on flexible carrier layer 21, in electrical connection with wiring that connects peripheral circuit 23 to detector cells 22. This is illustrated by
In a fifth step 15 an X-ray conversion layer 25 is provided, having a size that is sufficient to cover array of detector cells 22 and a perimeter area adjacent to the array of detector cells 22 as illustrated in
When an X-ray to charge X-ray conversion based imaging device is manufactured, an X-ray to charge conversion layer is provided and an X-ray transparent top electrode is provided on top of X-ray to charge conversion layer. Suitable X-ray to charge conversion materials are known per se. For example amorphous selenium (a-Se) or a perovskite may be used, such as Methyl Ammonium Lead Iodide (MAPI) direct conversion layer: (CH3)3NPbI3) and Cesium Lead Bromide (CsPbBr3).
In an embodiment, the layer thickness of the X-ray conversion layer 25 may be in a range of 100 micrometer to 1000 micrometer.
In a sixth step 16, X-ray conversion layer 25 is laminated onto detector cells 22 and peripheral area(s) 22b, as illustrated in
In the embodiment of the X-ray to charge X-ray conversion based imaging device, the capacitor 102 of the detector cell of
Instead of providing a previously prepared X-ray conversion layer 25 and laminating it onto detector cells 22 and peripheral area(s) 22a, by means of fifth and sixth steps 15, 16, X-ray conversion layer 25 may be deposited on detector cells 22 and peripheral area(s) 22a, e.g. by means of a printing process or other material deposition process.
In a seventh step 17, glass plate 20 is delaminated from flexible carrier layer 21, leaving a finished device, without glass plate 20 as illustrated in
Preferably, a ratio of the stiffness of the flexible carrier layer 21 and the stiffness of the X-ray conversion layer 25, or further layer of which it is part, has a value so that the stiffness of the X-ray imaging device is substantially determined by the stiffness of the further layer. For example, the ratio may have a value so that the stiffness of the X-ray imaging device with the flexible layer and the X-ray conversion layer 25, or further layer, is not more than ten percent higher than that of the X-ray conversion layer 25, or further layer. This does not depend on how the stiffness values are determined, as long as they are determined in the same way. For example the stiffness of each layer can be determined from the degree of bending of the layer when one end of the layer is fixed and a force perpendicular to the layer is exerted at the opposite end. The stiffness of the scintillation layer or further layer is mainly determined by the thickness of the scintillation layer. This allows for deformation of the X-ray imaging device to fit the device into place during use.
In operation during X-ray detection, X-ray conversion layer 25 directly or indirectly charges the capacitors that includes the plate electrodes in the cells of the array detector cells 22. In a first embodiment, direct charging may be used, wherein the X-ray to charge conversion layer directly generates an electric current to charge the plate electrode in response to X-rays. In a second embodiment indirect charging is used wherein the photo diode 100 in the detector cells act as photo-detector charges the plate electrode of the detector cell that generate electric current in response to light produced by the scintillator layer 25 in response to X-rays.
First layer part 40 and second layer part 42 may be laminated onto the device together at the same time or one after the other in separate steps.
As shown, a cavity in first layer part 40 is provided over peripheral circuit 23. Instead first layer part 40 may comprise an opening over peripheral circuit 23. In an embodiment, the cavity or opening may at least partly be filled with X-ray absorbing or reflecting material to shield peripheral circuit 23 against incoming X-rays.
Devices of the type described in the preceding may be stacked, for example to provide for simultaneous imaging of X-rays in different wavelength bands. When such embodiments are used, the stack will be exposed to X-rays from one surface side and the X-rays will be converted as they travel through the stack from that surface.
Such a stack of devices A, B may be manufactured for example by manufacturing both devices A, B as described in the preceding. In this process, before providing the X-ray conversion layer 25 on the flexible layer 21 and array of detector cells 22 of one of the devices A, B, the X-ray conversion layer 25 of that one of the devices A, B is provided on the X-ray conversion layer 25 of the other device B,A, if need be with one or more conductor layers 50 in between. In an embodiment, the X-ray conversion layers 25 of both devices A,B may be created as a single X-ray conversion layer 25, of the same composition, or with a composition that varies with height. The composition variation with height may be used to cause detection of conversion in different X-ray wavelength bands in the different devices A,B.
Alternatively, the X-ray conversion layers 25 with conductive layers 50 on top may be attached to each other after they have been provided on the flexible layers. In this case the substrates may be detached before the X-ray conversion layers 25 are attached to each other, or after both have been detached or between detachment of the substrates from the devices A, B. Detachment of at least one substrate after attaching conversion layers 25 to each other prevents bending during attachment attaching conversion layers 25 to each other.
In another embodiment the flexible layers of the stacked devices A, B may be attached back to back, so that the arrays of detector cells22 are located between the X-ray conversion circuit. This requires detachment of the substrates from both devices A, B before assembly of the stack. Moreover, when scintillation layers are used as X-ray conversion layers, a layer that is optically not transparent and X-ray transparent.
Although examples of a two device stack have been shown, it should be appreciated that more than two devices may be stacked. By using X-ray conversion layers that extend over the entire array of detector cells of the devices the risk of damage during assembly due to bending of the part of flexible layer 21 on which the detector cells are located is reduced. Preferably, flexible layers 21 in the stack do not extend laterally beyond the X-ray conversion layers, or the layers that contains the X-ray conversion layer. This reduces the risk of damage in the stack.
Number | Date | Country | Kind |
---|---|---|---|
20161170.4 | Mar 2020 | EP | regional |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/NL2021/050147 | 3/4/2021 | WO |