Claims
- 1. In the coupling of a carbohydrate moiety to a peptide chain, the improvement which comprises forming an amide bond between a peptide in the peptide chain and the carbohydrate moiety using bis-(trichloromethyl) carbonate, diphosgene or phosgene.
- 2. A peptide selected from the group consisting of:
17A) PheC2-NMeAla-Ala-AlaN3-NH2; 17B) GlyC1-Ala-Lys-(D)Ala-Ala-AlaN3-NH2; 18) Ala-Ala-Lys-(D)Ala-Ala-AlaC2-NH2; 19A) (D)Ala-AlaN2-Ala-Lys-(D)Ala-Ala-AlaC3-NH2; 19B) AlaN2-Ala-Lys-(D)Ala-Ala-AlaC3-NH2; 20A) GlyC1-Ala-Lys-(D)Ala-Ala-AlaN2-NH2; 20B) PheC2-N-MeAla-Ala-AlaN2-NH2; 22) (D)Ala-AlaN2-Ala-Lys-(D)Ala-Ala-AlaC3-NH2; 31) TrpC3-Ser-Glu-Tyr-Leu-PheN2-Gln-NH2 (SEQ ID NO:1); 37) PheC1-Phe-Phe-(D)Trp-(L)Lys-PheN2-NH2; 38) PheC1-Phe-Phe-(D)Trp-(D)Lys-PheN2-NH2; 39) PheC1-Phe-Leu-(D)Trp-(D)Lys-PheN2-NH2; 41) Biotin-Trp-Arg-Lys-(D)Arg-Phe-AlaC3-NH2; 42) PheC1-Ala-Phe-AlaN2-NH2; 47) Phe-NMePhe-NMePhe-NH2; 48) NMePhe-NMePhe-NMePhe-NH2; 51) Thr-AlaC2-Ser-Glu-Asn-His-Leu-Arg-His-Ala-LeuN3-Ser-NH2 (SEQ ID NO:2); 52) Thr-AlaC3-Ser-Glu-Asn-His-Leu-Arg-His-Ala-LeuN3-Ser-NH2 (SEQ ID NO:3); 56) TrpC3-Ser-Glu-Tyr-LeuN3-Amb-Ala-Arg-NH2 (SEQ ID NO:4); and 57) Biotin-Trp-Arg-Lys-(D)Arg-Phe-AlaC3-Leu-Arg-(D)Tyr-AlaN3-NH2.
Priority Claims (1)
Number |
Date |
Country |
Kind |
125314 |
Jul 1998 |
IL |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a division of U.S. application Ser. No. 09/756,223 filed Jan. 9, 2001, which is a continuation of the U.S. national stage designation of International Application no. PCT/IL99/00378 filed Jul. 11, 1999, the content of which is expressly incorporated herein by reference thereto.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09756223 |
Jan 2001 |
US |
Child |
10321648 |
Dec 2002 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/IL99/00378 |
Jul 1999 |
US |
Child |
09756223 |
Jan 2001 |
US |