Product for moisturizing an eye

Information

  • Patent Grant
  • 6297289
  • Patent Number
    6,297,289
  • Date Filed
    Monday, May 7, 2001
    23 years ago
  • Date Issued
    Tuesday, October 2, 2001
    22 years ago
Abstract
Substances, methods and devices for moisturizing the eye by stimulation of the lachrymatory glands to cause generation of tears.
Description




BACKGROUND OF THE INVENTION




This invention relates to methods, apparatus and substances for moisturizing the eye and particularly to moisturizing the eye with natural tears, i.e., by inducing natural tear production rather than introducing artificial tears.




Many people suffer from what is commonly known as “dry eye”. The condition arises from lack of sufficient tear production and results in a variety of symptoms such as burning, itching and undue sensitivity to smoke. The condition is more common in older adults inasmuch as a gradual lessening of tear production is a natural concomitant of the aging process. However, younger persons also suffer dry eye as a pathological disorder and the problem is particularly acute with the wearers of contact lenses. In this case, tear production may be entirely adequate for normal purposes but insufficient to provide adequate wetting and lubrication to permit wearing such lenses in comfort.




As any wearer of contact lenses knows, the low humidity of the average home or office in winter, windy days, and other ambient climatological conditions greatly aggravate the situation and often times precludes wearing contact lenses. With prolonged wear under drying conditions, the eye sometimes generates mucous which coats the lenses to the point that they can become opaque. If this occurs while the wearer is reading, say, a research paper before a learned society or making a presentation at a business meeting, it can be embarrassing; while driving, dangerous.




With more than discomfort involved, it is important that the eyes be quickly, easily, and effectively moisturized and there is a need to do this without embarrassment in public places and social situations.




THE PRIOR ART




At the present time numerous eye moisturizing products are available ranging from simple artificial tears to lens clearing and lubricating solutions and additives calculated to “get the red out”.




While these products vary widely in effectiveness, cost and the claims made for them, they have one thing in common: insofar as is known, all are liquids intended for macroscopic introduction into the eye in the form of drops and are packaged either in plastic squeeze-bottle droplet dispensers or glass containers having caps fitted with an eye dropper. They are intended to be administered by tilting back one's head, putting the dropper nozzle over and in proximity to the eye (being careful to observe the label warning not to touch the tip lest the contents of the dispenser become contaminated), and allow a drop or two to fall into one eye at a time.




Another method of administration of liquid drops involves pulling down the lower eyelid to form a pocket and placing the drops into the pocket.




With practice, some users become so proficient with one or the other technique that they can get a high percentage of the drops dispensed to fall into the eye. Near misses can be dealt with if tissues are handy and, if not, the drops roll harmlessly down the cheeks, the only occasional casualty being smeared mascara unless of course one is foolish enough to attempt the administration while driving!




From the foregoing it will be noted that a well-equipped wearer of contact lenses should carry: a lens case (to store the lenses in the event that dryness forces their removal); a pair of corrective spectacles to substitute for the “contacts”; a bottle of eye drops; and a supply of tissues.




Those persons who do not wear or aspire to wear contact lens but have dry eye suffer only slightly fewer vexations, viz., they are not burdened with the contact wearers paraphernalia.




With the foregoing state of the art in view, it is the object of this invention to overcome or at least mitigate the problems of the prior art as outlined above.




A further object is the provision of methods and means for moisturizing the eye without introducing moisturizing liquid into the eye.




Another object is to provide methods and means for inducing “dry eyes” to generate natural tear in situ. A still further object is to provide means for moisturizing the eye which can be employed discretely and without attracting notice in public places.




BRIEF DESCRIPTION OF THE INVENTION




To the fulfillment of these and other objects, the invention contemplates a method for moisturizing the eye by the microscopic introduction into the eye in gaseous or vapor form, a substance causing the generation of tears by the lachrymatory glands.




The substance is a lachrymatory agent vaporizable at room temperature diluted to a concentration which causes tearing of the eye without untoward smarting or irritation.




The invention further contemplates a device for moisturizing the eye comprising a container having an opening and a closure member normally closing the opening. Means are provided for opening the closure member and a lachrymatory agent as described above is disposed in the container.




A kit comprising an amount of lachrymatory agent and means for dispensing an effective amount of said lachrymatory agent to cause tears.











BRIEF DESCRIPTION OF THE DRAWINGS





FIG. 1

is a side elevation, partly in section on the vertical center line, of a device for moisturizing the eye embodying the invention.





FIG. 2

is an elevational view taken on line


2





2


of

FIG. 1

, looking in the direction of the arrows.





FIG. 3

is a top plan view of

FIGS. 1 and 2

.





FIG. 4

is an elevational view of the structure in

FIG. 1

with parts in an alternate position.





FIGS. 5

,


6


and


7


are views similar to

FIG. 4

showing modified embodiments of the invention.











DESCRIPTION OF PREFERRED EMBODIMENTS




It has been determined that the smarting and tearing effect associated with peeling onions is caused by propanethial-s-oxide (‘PSO”) and related compounds naturally occurring in onions. (See “PROPANETHIAL-S-OXIDE”, Chemical Abstracts Registry #3215729-2). The compounds are quite volatile, vaporizing at room temperature. These compounds, the most significant of which is propanethial-s-oxide, and other compounds having similar chemical and physical properties, viz., lachrymatory activity and volatility, can be diluted and utilized to stimulate tearing to combat pathogenic and benign dry eye conditions.




The method of moisturizing the eye contemplated by the invention consists of the fundamental step of introducing into the eye, in vapor, gaseous or otherwise microscopic form, a lachrymatory compound(s) naturally occurring in onions. For the purposes of this specification the term microscopic is defined to encompass misting, vaporous or gaseous methods of introducing lachrymatory agents into the eye. The lachrymatory compounds may be appropriately diluted to a concentration that is suitable to the individual using it. The concentration must be determined empirically as the strength of the compounds in onions varies widely with the variety of onion used, growing conditions, etc. The desideratum is a concentration which produces sufficient tearing without undue burning or smarting of the eye.




The preferred composition comprises an amount of PSO and related compounds to produce tears after a short exposure time. The purity of the compounds will have a direct effect on the production of tears. It is preferred to use pure PSO and related compounds, although the PSO and related compounds maybe diluted to promote the volatility of the PSO. Common pharmaceuticals adjuvants may also be added to the compositions to produce the desired composition. Said common pharmaceutical adjuvants can be found in Remingtons Pharmaceutical Sciences, fifth edition, by Mack Publishing Company, which publication is herein specifically incorporated by reference. The desired composition may be any that is known to those skilled in the art and can be based on, for example, an aerosol composition employing a propellant, or a volatile composition using volatility enhancers, such as, for instance, ethyl alcohol.




A device for introducing the lachrymatory agent will now be described with reference to the drawings and, first, to

FIGS. 1

to


4


showing a container


10


having an opening


12


at its upper end. A cap assembly


14


includes a mounting band


16


tightly encircling opening


12


and a captive closure member


18


secured to the band by a hinge


20


consisting of a strip of flexible plastic or other material.




Closure member


18


is of the type often referred to as a “snap-cap” and is closed by means of downward finger pressure applied on its top surface, preferably at a point diametrically opposite hinge


20


. In this condition, the cap closes opening


12


.




A radially projecting tab


22


on cap


18


facilitates opening the container which is accomplished by upward pressure on the tab. Thus opening can be accomplished with a single finger, usually the thumb, by pushing tab


22


upwardly; when in the open position, shown in

FIG. 4

, the cap is held captive by hinge


20


.




Container


10


has a generally ovate cross-section as appears in

FIG. 3

, lending itself to a comfortable fit in the user's palm and permitting easy removal and replacement of the cap.




Container


10


is filled to the desired level with the lachrymatory agent; preferably the agent is absorbed in a matrix of suitable absorbent material such as cotton shown at


24


in FIG.


1


. Whether or not a matrix is used, it is preferred that a wick


26


be disposed in the container extending from a point at or near its bottom


28


and extending to opening


12


, terminating flush with the face of the opening.




To moisturize the eye, the user simply positions the opening of the container close to his eye, opening the cap before or after doing so. (There is no need to tilt the head back.) The vapor from the container enters the eye and almost immediately stimulates tear production by the lachrymatory glands. After a few moments, i.e., when the desired effect is obtained, the process is repeated with the other eye. Then the cap is replaced and the container restored to purse or pocket.




An alternative form of the moisturizer is shown in

FIG. 5

wherein the cap assembly


14


′ is modified as compared to

FIGS. 1-4

by the substitution of a spring hinge


20


′ for hinge


20


.




Spring hinge


20


′ resiliently biases cap


18


toward its open position and a latch is provided diametrically opposite the hinge. When engaged, the latch maintains the cap in closed position against the bias effect of the spring. A latch release button


32


, when pressed, causes the cap to snap open; it is closed by applying downward pressure on the top surface of the cap in the same manner as the previously described embodiment. The use of the

FIG. 5

moisturizer is entirely analogous to and will be readily apparent from the above-described use of the device in

FIGS. 1-4

.





FIGS. 6 and 7

show further embodiments of the invention each including a preferably soft plastic cup-shaped member


34


and


34


′, respectively, mounted on a container


10


. Members


34


,


34


′ are configured and dimensioned to fit over the eye and are, in use, selectively placed in flow communication with the interior of the container so as to guide and confine vapor issuing there from to the ocular region.




The

FIG. 6

embodiment is a non-aerosol, pump-type dispenser which ejects a measured quantity of the contents of the container


10


each time the member


34


is depressed as by finger pressure on the flat


35


provided thereon for the purpose.





FIG. 7

illustrates an aerosol-type unit in which the contents of container


10


are under pressure and a metered quantity ejected into member


341


when a valve actuation button


36


is pressed. It will be understood that the construction and operation of the pump and aerosol dispensing devices per se are well known. However the substance issuing from the device is not an aerosol or spray but a vapor.




The use of the devices shown in

FIGS. 6 and 7

is completely analogous to that of the

FIG. 1-4

embodiment of the invention already described except, of course, that the cup-shaped member


34


,


34


′ is placed over the eye before dispensing the lachymatory vapor.




The use of a kit comprising means for dispensing lachrymatory agent and the lachrymatory agent itself is also within the scope of this invention. A preferred kit would use an apparatus for dispensing said lachrymatory agent as described above containing a lasting supply of lachrymatory agent. Such kit would be packaged in a shrink wrapped package or a hard plastic protection pack. The packaging material used in the kit can be any material known to those skilled in the art. Such materials can include cardboard, plastic and any combination of the two, for example.




From the foregoing description of exemplary embodiments, it will be seen that the objects of the invention are achieved, enabling moisturization of the eyes discretely and effectively, using a single hand, without tilting the head or possibility of misapplication of liquid drops. The scope of this invention is intended to include all such modifications that would be obvious to one of ordinary skill in the art.



Claims
  • 1. A product for combating a pathogenic, benign, dry or irritated eye condition comprising:a container having a normally closed opening and an interior compartment, the interior compartment holding an amount of propanethial-s-oxide sufficient to provide a plurality of individual dosages of sufficient strength to induce tearing in a mammalian eye; and a closure member cooperating with said opening and being selectively movable between a normally closed position, and an open position for releasing a microscopic quantity of propanethial-s-oxide through said opening.
  • 2. The product according to claim 1, wherein the container is a bottle and the closure member is a cap suitable for covering the bottle.
  • 3. The product according to claim 1, wherein the closure member is spring-biased towards the open position and the product includes a releasable latch for normally maintaining the closure member in the closed position.
  • 4. The product according to claim 1, wherein the closure member is secured to the container by a flexible hinge.
  • 5. The product according to claim 4, wherein the closure member is provided with a radially projecting tab which, upon upward pressure, moves the closure member from the normally closed position to the open position.
  • 6. The product according to claim 1, wherein the closure member comprises a non-aerosol pump-type dispenser which ejects a measured quantity of propanethial-s-oxide each time the dispenser is depressed.
  • 7. The product according to claim 1, wherein the closure member comprises a valve actuated by a button and propanethial-s-oxide within the interior compartment is under pressure.
  • 8. The product according to claim 1, further comprising a matrix material situated in the interior compartment, wherein the propanethial-s-oxide is absorbed in said matrix material.
  • 9. The product according to claim 8, wherein the matrix material is cotton.
  • 10. The product according to claim 8, further comprising a wick situated in the interior compartment, the wick extending from a point at or near a bottom of the interior compartment, to said container opening.
  • 11. The product according to claim 1, further comprising a wick situated in the interior compartment, the wick extending from a point at or near a bottom of the container, to its opening.
  • 12. The product according to claim 1, further comprising a cup-shaped member attached to the product and configured and dimensioned to fit over an eye.
  • 13. The product according to claim 1, placed in a package.
  • 14. The product according to claim 1, wherein the package comprises plastic, cardboard or a combination of plastic and cardboard.
  • 15. A product for combating a pathogenic, benign, dry or irritated eye condition comprising:a container having a normally closed opening and an interior compartment, the interior compartment holding an amount of a lachrymatory agent sufficient to provide a plurality of individual dosages of sufficient strength to induce tearing in a mammalian eye; and a closure member cooperating with said opening and being selectively movable between a normally closed position, and an open position for releasing a microscopic quantity of said lachrymatory agent through said opening, and a package comprising plastic, cardboard or a combination of plastic and cardboard, said package holding said container and said closure member.
  • 16. The product according to claim 15, wherein the lachrymatory agent comprises propanethial-s-oxide.
  • 17. The product according to claim 16, wherein the closure member is spring-biased towards the open position and the product includes a releasable latch for normally maintaining the closure member in the closed position.
  • 18. The product according to claim 16, wherein the closure member is secured to the container by a flexible hinge.
  • 19. The product according to claim 16, wherein the closure member comprises a non-aerosol pump-type dispenser which ejects a measured quantity of said lachrymatory agent, each time the dispenser is depressed.
  • 20. The product according to claim 16, wherein the closure member comprises a valve actuated by a button and the lachrymatory agent within the interior compartment is under pressure.
  • 21. The product according to claim 16, further comprising a matrix material situated in the interior compartment, wherein the lachrymatory agent is absorbed in said matrix material.
  • 22. A product for combating a pathogenic, benign, dry or irritated eye condition comprising:a container having a normally closed opening and an interior compartment, the interior compartment holding an amount of a lachrymatory agent sufficient to provide a plurality of individual dosages of sufficient strength to induce tearing in a mammalian eye; and a closure member cooperating with said opening and being selectively movable between a normally closed position, and an open position for releasing a microscopic quantity of said lachrymatory agent through said opening.
RELATED APPLICATIONS

This is a Continuation of patent application Ser. No. 08/164,879, filed Dec. 9, 1993, now U.S. Pat. No. 6,251,952, which is a Continuation-in-part of patent application Ser. No. 07/645,175, filed Jan. 24, 1991, now abandoned.

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Number Name Date Kind
2235453 Kirmes Mar 1941
2681252 Tuttle Jun 1954
3207441 Schreiber Sep 1965
3361306 Grim Jan 1968
3559851 Steiman Feb 1971
3679133 Sekiguchi et al. Jul 1972
4010875 Babiol Mar 1977
4017030 Coplan et al. Apr 1977
4539450 Lorenz et al. Sep 1985
4680283 Veber et al. Jul 1987
4728037 Mainhardt Mar 1988
4944429 Bishop Jul 1990
5002228 Su Mar 1991
Foreign Referenced Citations (3)
Number Date Country
504353 Apr 1939 GB
49-35198 Aug 1972 JP
63-280015 Nov 1988 JP
Non-Patent Literature Citations (5)
Entry
M. H. Brodnitz and J. V. Pascale, Thorpropanal S-Oxide: A Lachrymatory Factor in Onions, J. Agr. Food Chem., vol. 19, No. 2, 1971 pp. 269-272.
M. Nagarajan, H. Schecter, Structure and Origin of the Onion Lachrymatory Factor. A Microwave Study, Journal of the American Chemical Society, vol. 101 and 102, No. 8 and No. 7, Apr. 11, 1979 and Mar. 26, 1980 pp. 2200-2201, and pp. 2490-2491.
K.L. Bajaj, Chemical Evaluation of some Important Varieties of Onion, Vegetable Crops, Lanscaping and FloriculturePunjab Agricultural Univ., Ludhiana- 1410045, India, Qualitas Plantarum 30 (2) pages 117-122.
E. Block, et al., The Lachrymatory Factor of the Onion: an NMR Study, Tetrahedron Letters vol. 21, 1980, pp. 1277-1280.
K.L. Bajaj et al., The Lachrymatory Factor and Other Chemical Constituents of Some Varieties of Onion, Journal of Plant Foods vol. 3, 1979 pp. 199-203.
Continuations (1)
Number Date Country
Parent 08/164879 Dec 1993 US
Child 09/849367 US
Continuation in Parts (1)
Number Date Country
Parent 07/645175 Jan 1991 US
Child 08/164879 US