Patent Grant
10731125
The Sequence Listing associated with this application is filed in electronic format via EFS-Web and hereby incorporated by reference into the specification in its entirety. The name of the text file containing the Sequence Listing is 127299_00411_Sequence_Listing. The size of the text file is 27 KB, and the text file was created on Aug. 29, 2018.
This disclosure relates to compositions capable of programmed delivery of therapeutic agents to cancer cells or other cells related to a hyperproliferative disorder in a subject. This disclosure further relates to method of programming at least one bacteria comprising an inducible promoter and a nucleic acid sequence encoding a cellular toxin that modulates the delivery of a therapeutic agent or is itself a therapeutic agent. The bacteria of the invention can be genetically engineered for use in the methods or other aspects of the invention described herein.
The engineering of bacteria to controllably deliver therapeutics is an attractive application for synthetic biology. While most synthetic gene networks have been explored within microbes, there is a need for further characterization of in vivo circuit behavior in the context of applications where the host microbes are actively being investigated for efficacy and safety, such as tumor drug delivery. One major hurdle in is that culture-based selective pressures are absent in vivo, leading to strain-dependent instability of plasmid-based networks over time. Here, we experimentally characterize the dynamics of in vivo plasmid instability using attenuated strains of S. typhimurium and real-time monitoring of luminescent reporters. Computational modeling described the effects of growth rate and dosage on live-imaging signals generated by internal bacterial populations. This understanding will allow us to harness the transient nature of plasmid-based networks to create tunable temporal release profiles that reduce dosage requirements and increase the safety of bacterial therapies.
Over the past century, the ability of bacteria to accumulate preferentially in tumors has prompted the investigation of the use of a number of strains for cancer therapy, including C. novyi, E. coli, V. cholorae, B. longum, and S. typhimurium ([3], [12], [2], [24], [15], [21]). Attenuated strains of S. typhimurium have generated particular interest as they can innately home in on tumors and colonize a variety of sizes, and have exhibited safety and tolerance in human clinical trials ([22], [5], [19], [8]]). S. typhimurium were initially shown to have anti-tumor effects through recruitment of the host immune system and competition with cancer cells for nutrients. Subsequently, engineered production of therapeutic cargo was added through simple genetic modifications. While these studies represent important advances in the use of bacteria for tumor therapies, the majority have relied on constitutive, “always on” cargo production ([9], [23], [14], [6]) that typically results in high dosages, off-target effects, and development of host resistance.
As a next step, synthetic biology seeks to add controlled and dynamic production of cargo by utilizing computationally-designed “circuits” that have sophisticated sensing and delivery capability ([7], [4], [17]s[1]). These circuits can be designed to act as delivery systems that sense tumor-specific stimuli and self-regulate cargo production as accessory. Since plasmids are the common framework for synthetic circuits, we begin by characterizing the dynamics of plasmid-based gene expression in vivo by utilizing real-time luminescence imaging, quantitative biodistribution measurement, and computational modeling. Together, these approaches provide a framework for exploiting the inherent instability of plasmid-based networks, which will facilitate the generation of specific temporal release profiles directly within the tumor environment.
The invention relates to a method of delivering a therapeutic agent to a cancer cell by administering at least one bacterial cell to a subject, the bacterial cell comprising a therapeutic agent operably linked to at least one transcriptional element or promoter, wherein the transcriptional element modulates the expression or secretion of the therapeutic agent in response to the presence of a density or quantity of bacteria comprising the at least one transcriptional element or promoter. In some embodiments, the transcriptional element or promoter is non-constitutive.
The invention relates to a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
In some embodiments, the composition comprises at least one bacterial cell, wherein the at least one non-pathogenic bacterial cell is chosen from one or a combination of bacterial cells of the genera chosen from: Salmonella, Escherichia, Firmicutes, Bacteroidetes, Lactobacillus, Bifidobacteria, or Acidopholus.
In some embodiments, the composition disclosed herein, wherein the bacterial cell comprises no more than five exogenous nucleic acid sequences that are coding sequences, wherein the first exogenous nucleic acid sequence comprises at least one non-constitutive promoter operably linked to the second exogenous nucleic acid sequence that encodes the at least one therapeutic agent.
In some embodiments, the invention relates to a composition comprising at least one bacterial cell, wherein the bacterial cell comprises a first, a second, and a third exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises at least one inducible promoter, the second exogenous nucleic acid sequence encodes at least one therapeutic agent, and the third exogenous nucleic acid sequence encodes at least one amino acid sequence that directs targeting of the at least one therapeutic to a cancer cell or a cell associated with a hyperprolierative disorder. In some embodiments the promoter is operably linked to the nucleic acid sequence encoding a therapeutic agent and/or to the nucleic acid sequence encoding an amino acid that directs targeting of the at least one therapeutic agent to a cancer cell or a cell associated with a hyperprolierative disorder.
In some embodiments, the invention relates to a composition comprising at least one bacterial cell, wherein the bacterial cell comprises a first, a second, and a third exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises an inducible promoter, the second exogenous nucleic acid sequence encodes a therapeutic agent, and the third exogenous nucleic acid sequence encodes an amino acid sequence that directs targeting of the at least one therapeutic to the a cancer cell or a cell associated with a hyperproliferative disorder, and wherein the first, second, and third nucleic acid sequences reside on a single DNA plasmid.
In some embodiments, the invention relates to a composition comprising at least one bacterial cell, wherein the at least one bacterial cell comprises either: (a) a first, a second, and a third exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises an inducible promoter, the second exogenous nucleic acid sequence encodes a therapeutic agent, and the third exogenous nucleic acid sequence encodes an amino acid sequence that directs targeting of the at least one therapeutic to the a cancer cell or a cell associated with a hyperproliferative disorder, and wherein the first, second, and third nucleic acid sequences reside on at least one DNA plasmid; or (b) a first and a second exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises an inducible promoter, and the second exogenous nucleic acid sequence encodes a therapeutic agent, and the third exogenous nucleic acid sequence encodes an amino acid sequence that directs targeting of the at least one therapeutic to the a cancer cell or a cell associated with a hyperproliferative disorder, and wherein the first and second exogenous nucleic acid sequences reside on at least one DNA plasmid.
In some embodiments, the composition comprises at least one bacterial cell comprising a nucleic acid sequence that is an inducible and non-constitutive promoter, wherein the promoter is responsive to a single stimulus, wherein the stimulus comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second exogenous nucleic acid sequences. In some embodiments, the composition disclosed herein, the at least one stimuli are generated naturally by a microenvironment or tissue of a subject. In some embodiments, the microenvironment or tissue of the subject is a solid tumor in the subject.
In some embodiments, the composition disclosed herein, wherein the at least one stimuli comprise the presence of a bio film of bacteria.
In some embodiments, the composition comprises at least one bacterial cell comprising a nucleic acid sequence that encodes a therapeutic agent, wherein the therapeutic agent is a fusion protein encoded by the second nucleic acid sequence, the fusion protein comprising at least a first and second moiety, wherein the first moiety is a cellular toxin and the second moiety is a targeting sequence, the composition comprises at least one bacterial cell comprising a nucleic acid sequence that encodes a therapeutic agent, wherein the therapeutic agent is a fusion protein encoded by the second nucleic acid sequence, the fusion protein comprising at least a first and second moiety, wherein the first moiety is at least 70% homologous to SEQ ID NO:6 and the second moiety is at least 70% homologous to SEQ ID NO:5.
In some embodiments, the composition comprises at least one bacterial cell comprising a plasmid at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:1. In some embodiments, the composition comprises at least one bacterial cell comprising a plasmid at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:7. In some embodiments, a single plasmid encodes all of the exogenous nucleic acid sequences. In some embodiments, the at least one bacterial cells comprises or consists of SEQ ID NO:1 or SEQ ID NO:7.
In some embodiments, the composition comprises at least one bacterial cell comprising one or more exogenous nucleic acid sequences wherein at least one of the exogenous nucleic acid sequences is a coding sequence, and wherein each one or more exogenous nucleic acid sequences reside on a single plasmid.
In some embodiments, the composition comprises at least one bacterial cell comprising one or more exogenous nucleic acid sequences wherein each one or more exogenous nucleic acid sequences reside on a single plasmid consisting of or consisting essentially of SEQ ID NO:1.
In some embodiments, the invention relates to a composition comprising at least one bacteria cell disclosed herein, wherein the at least bacterial cell comprises at least two lux genes operably linked to one or more therapeutic agents. In some embodiments, the one or more therapeutic agents are one or more cellular toxins. In some embodiments, the composition comprises at least one bacterial cell, wherein the at least bacterial cell comprises at least two lux genes and one or more cellular toxins that is are least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ TD NO:6. In some embodiments, the cellular toxin is an amino acid encoded by a nucleic acid sequence at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:6 optionally fused to an amino acid encoded by a nucleic acid sequence at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:5. In some embodiments, the therapeutic agent is linked by a linker amino acid sequence at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:4.
In some embodiments, the invention relates to a composition comprising at least one bacterial cell disclosed herein, wherein the at least bacterial cell further comprises: (a) at least one exogenous nucleic acid sequence that encodes a marker amino acid sequence, and wherein the at least one exogenous nucleic acid sequences that encode a marker amino acid are optionally operably linked to the inducible promoter; or (b) at least one selectable marker.
In some embodiments, the invention relates to a pharmaceutical composition comprising: (a) the composition comprising any of the compositions disclosed herein, and (b) a pharmaceutically acceptable carrier or a pharmaceutically acceptable salt thereof. In some embodiments, the pharmaceutical composition disclosed herein, further comprises: (c) a chemotherapeutic compound.
In some embodiments, the invention relates to a pharmaceutical composition disclosed herein, wherein the pharmaceutical composition comprises one more radioactive isotopes, optionally incorporated into the at least bacterial cell. In some embodiments, the pharmaceutical composition comprises a therapeutically effective dose of the at least one bacterial cell. As used herein the terms “therapeutically effective dose” means the number of cells per dose administered to a subject in need thereof sufficient in number to ameliorate or reduce the burden of disease symptoms of the subject. In some embodiments, the terms “therapeutically effective dose” means the number of cells per dose administered to a subject in need thereof sufficient in number to reduce the rate of growth of a tumor or cancer cell or cell associated with a hyperproliferative disease, reduce the size of a tumor, or prevent the metastases of a tumor. In some embodiments, the pharmaceutical composition disclosed herein, wherein the therapeutically effective dose is from about 1×104 to about 1×107 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×101 to about 1×107 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×102 to about 1×107 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×103 to about 1×107 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×104 to about 1×107 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×105 to about 1×107 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×106 to about 1×107 bacterial cells.
In some embodiments, the therapeutically effective dose is from about 1×101 to about 1×106 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×102 to about 1×106 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×103 to about 1×106 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×104 to about 1×106 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×105 to about 1×106 bacterial cells.
In some embodiments, the therapeutically effective dose is from about 1×101 to about 1×105 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×102 to about 1×105 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×103 to about 1×105 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×104 to about 1×105 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×101 to about 1×104 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×102 to about 1×104 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×101 to about 1×103 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×103 to about 1×104 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×102 to about 1×103 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×101 to about 1×102 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10° to about 1×102 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10° to about 1×108 bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10° to about 1×109 bacterial cells. In some embodiments, the therapeutically effective dose of bacterial cells is more than 1×109 bacterial cells. In some embodiments, the therapeutically effective dose of bacterial cells is less than 10 cells.
In some embodiments, a food product comprising the composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. In some embodiments, the food product further comprises a natural or non-natural food additive.
The invention also relates to a kit comprising the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein. In some embodiments, the kit disclosed herein, further comprises a bacterial culture vessel. In some embodiments, the kit disclosed herein, further comprises a bacterial cell growth media.
In some embodiments, the at least one bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. In some embodiments, the at least one bacterial cell comprises a selectable marker or marker amino acid sequence. In some embodiments, the at least one bacterial cell comprises a marker amino acid sequence that is a luciferase gene or a functional fragment thereof.
In some embodiments, the at least one bacterial cell disclosed herein, wherein the at least one bacterial cell is a non-pathogenic bacterial cell. In some embodiments, the at least one bacterial cell disclosed herein, further comprising: (a) at least a third exogenous nucleic acid sequence that encodes at least one marker amino acid sequence; and (b) at least one selectable marker.
In some embodiments, the at least one bacterial cell comprises is a strain of bacteria chosen from Salmonella, Escherichia, Firmicutes, Bacteroidetes, Lactobacillus, Bifidobacteria, or Acidopholus. In some embodiments, the at least one bacterial cell disclosed herein, wherein the at least one cell is a strain of Salmonella typhimurium. In some embodiments, the at least one bacterium is a non-pathogenic bacterium. In some embodiments, the bacterium is attenuated or rendered non-pathogenic by mutating one or more virulence factors. In some embodiments, the at least one bacterium is chosen from any species listed on Table 1. In some embodiments, the at least one bacterium is chosen from any species listed on Table 1 and the strain is mutated to attenuate one or more virulence factors. In some embodiments, the non-pathogenic bacterium is a pro-biotic bacterium.
In some embodiments, the invention relates to a method of treating or preventing cancer comprising administering to a subject in need thereof the a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one inducible and/or non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the at least one inducible and/or non-constitutive promoter is responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. In some embodiments, the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein. In some embodiments, the compositions, pharmaceutical compositions or food products are delivered to a subject in need thereof per os, per anus, per muscosal lavage, via intravenous injection, subcutaneous injection, via any form of injection.
In some embodiments, the invention relates to a method of reducing the growth of a cancer cell, solid tumor, or cell associated with a hyperproliferative disorder comprising administering to a subject in need thereof the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed in paragraph herein. In some embodiments, the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.
In some embodiments, the invention relates to a method disclosed herein, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein.
In some embodiments, the invention relates to a method of delivering one or more therapeutic agents to a tumor in a subject comprising administering the composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences; or the pharmaceutical composition disclosed herein, or the food product disclosed herein to the subject in need thereof. In some embodiments, the only stimulus for inducing expression of the therapeutic agent is the density or quantity of bacteria in a given microenvironment where the at least one bacterial cell colonizes. In some embodiments, the microenvironment is chosen from at or around a cancer cell, a cell associated with a hyperproliferative disorder, a solid tumor, or a metastatic tumor, or a grafted tumor.
In some embodiments, the invention relates to a method disclosed herein, wherein the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method docs not comprise administering any light to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method does not comprise administering any chemical agent to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject prior to, simultaneously with, or subsequent to administration of the at least one bacterial cell.
In some embodiments, the invention relates to any of the methods disclosed herein, wherein the method comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject in need thereof one or more times subsequent to administration of the composition disclosed in herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein.
The invention also relates to a method of reducing tolerance to a therapeutic agent in a subject in need thereof comprising administering the composition disclosed in herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein to the subject in need thereof. In some embodiments, the method of reducing tolerance to a therapeutic agent further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.
In some embodiments, the method of reducing tolerance to a therapeutic agent does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject.
In some embodiments, the invention also relates to a method of manufacturing the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein comprising transforming at least one of nucleic acid comprising at least one inducible and/or non-constitutive promoter into at least one or a combination of bacterial cells. In some embodiments, the method of manufacturing the compositions and food products herein further comprises culturing any of the at least one or a combination of bacterial cells in a tissue culture vessel.
The invention also relates to a pharmaceutical composition comprising the at least one bacterial cell disclosed herein for treatment or prevention of cancer, growth of cells associated with a hyperproliferative disorder, or metastases.
The invention also relates to a pharmaceutical composition comprising the at least one bacterial cell disclosed herein manufactured in a medicament for cancer, growth of cells associated with a hyperproliferative disorder, or metastases.
Embodiments include methods of using tumor-targeted bacteria to identify a therapeutically effective dose of therapeutic agent in a solid tumor, the method comprising administering any of the compositions, pharmaceutical compositions, or food products disclosed herein to a subject in need thereof, in some embodiments, the subject is suspected of having or has been diagnosed with cancer or metastatic cancer.
Some embodiments relate to bacteria which comprise heterologous nucleic acid sequences. The bacteria colonize tumors. In some embodiments, the non-pathogenic bacteria are non-pathogenic bacteria that colonize tumor cells or cancer cells, or cell associated with a hyperproliferative disorder, and, at a certain concentration or cell density, the bacteria secrete, release, or enhance the activation of a therapeutic agent. In some embodiments, the bacteria that comprise heterologous nucleic acid sequences comprise at least one inducible promoter or non-constitutive promoter. Some embodiments provide compositions comprising at least one bacterial cell disclosed herein.
In some embodiments, the compositions are pharmaceutical compositions that comprise at least one bacterial cell disclosed herein and at least one pharmaceutically acceptable carrier. Some embodiments provide pharmaceutical compositions of the claimed invention that are useful to treat and/or prevent cancer. Some embodiments are useful to treat or prevent metastases. Some embodiments are useful to treat or prevent tumor growth.
Some embodiments provide compositions comprising at least one bacterial cell that comprises one or more exogenous plasmids, wherein at least one plasmid comprises a heterologous nucleic acid sequence that encodes a therapeutic agent operably linked to an non-constitutive and/or inducible promoter; such non-constitutive and/or inducible promoter modulates the expression of the nucleic acid encoding the therapeutic agent in the presence of at least one stimulus. In some embodiments, the inducible and non-constitutive promoter only induces the expression of the nucleic acid encoding the therapeutic agent in the presence of a certain density or number of bacterial cells comprising the inducible promoter and/or the nucleic acid that encodes the therapeutic agent. When such a bacterial cell reproduces in vivo, such as when the bacterial cell colonizes a tumor in an animal, the clonally derived progeny of the at least one bacterial cells may reach a certain density or number that such density or number triggers the expression of the therapeutic agent. The ability of a bacterial cell to modulate expression of a gene in the presence of a certain number or density of cells is quorum sensing. In some embodiments, the non-constitutive or inducible promoter has only a single stimulus that is a certain number or density of cells. In some embodiments, the non-constitutive and/or inducible promoter responds to at least one, two, three, four, five or more stimuli but none of the stimuli require administration or exposure of the stimulus or stimuli external to the subject. In some embodiments, the stimulus or stimuli necessary to induce expression of the nucleic acid encoding the therapeutic agent require exposure to or administration of a cofactor before, simultaneously to, or after administration of the at least one bacterial cell.
In some embodiments, the at least one bacterial cell optionally comprises a nucleic acid sequence that encodes a polarization protein or functional fragment thereof and/or a nucleic acid sequence that encodes a combination of a toxin and an antidote. When such microorganism reproduces in vivo, such as when they are colonizing a tumor in an animal, a greater proportion of the resulting progeny remain plasmid-bearing compared to the proportion of resulting progeny from bacteria which do not comprise a nucleic acid sequence that encodes a polarization protein, or functional fragment thereof and/or a nucleic acid sequence that encode a combination of a toxin and an antidote. The polarization protein, or optionally, the combination of the polarization protein and a toxin and an antidote, reduces plasmid loss that occurs during cell division and facilitates the inclusion of both the plasmids in the at least one bacterial cell and its progeny upon cellular division. This feature of improves therapeutics that use bacteria that target and colonize tumors and release therapeutics or products involved in tumor detection. In some embodiments, the bacteria further comprise a nucleic acid sequence that encodes a protein used in therapeutic methods that cause slowed or inhibit tumor growth or reduce or eliminate tumors.
Specific preferred embodiments of the present invention have been described here in sufficient detail to enable those skilled in the art to practice the full scope of invention. However it is to be understood that many possible variations of the present invention, which have not been specifically described, still fall within the scope of the present invention and the appended claims. Hence these descriptions given herein are added only by way of example and are not intended to limit, in any way, the scope of this invention. More generally, those skilled in the art will readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that the actual parameters, dimensions, materials, and/or configurations will depend upon the specific application or applications for which the teachings of the present invention is/are used. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, the invention may be practiced otherwise than as specifically described and claimed. The present invention is directed to each individual feature, system, article, material, kit, and/or method ‘described herein. In addition, any combination of two or more such features, systems, articles, materials, kits, and/or methods, if such features, systems, articles, materials, kits, and/or methods are not mutually inconsistent, is included within the scope of the present invention.
Various terms relating to the methods and other aspects of the present invention are used throughout the specification and claims. Such terms are to be given their ordinary meaning in the art unless otherwise indicated. Other specifically defined terms are to be construed in a manner consistent with the definition provided herein.
The term “about” as used herein when referring to a measurable value such as an amount, a temporal duration, and the like, is meant to encompass variations of ±20%, ±10%, ±5%, ±1%, or ±0.1% from the specified value, as such variations are appropriate to perform the disclosed methods.
The indefinite articles “a” and “an,” as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean “at least one.” The phrase “and/or,” as used herein in the specification and in the claims, should be understood to mean “either or both” of the elements so conjoined, i.e., elements that are conjunctively present in some cases and disjunctively present in other cases. Other elements may optionally be present other than the elements specifically identified by the “and/or” clause, whether related or unrelated to those elements specifically identified unless clearly indicated to the contrary. Thus, as a non-limiting example, a reference to “A and/or B,” when used in conjunction with open-ended language such as “comprising” can refer, in one embodiment, to A without B (optionally including elements other than B); in another embodiment, to B without A (optionally including elements other than A); in yet another embodiment, to both A and B (optionally including other elements); etc.
As used herein in the specification and in the claims, “or” should be understood to have the same meaning as “and/or” as defined above. For example, when separating items in a list, “or” or “and/or” shall be interpreted as being inclusive, i.e., the inclusion of at least one, but also including more than one, of a number or list of elements, and, optionally, additional unlisted items. Only terms clearly indicated to the contrary, such as “only one of or “exactly one of,” or, when used in the claims, “consisting of,” will refer to the inclusion of exactly one element of a number or list of elements. In general, the term “or” as used herein shall only be interpreted as indicating exclusive alternatives (i.e. “one or the other but not both”) when preceded by terms of exclusivity, such as “either,” “one of,” “only one of,” or “exactly one of “Consisting essentially of,” when used in the claims, shall have its ordinary meaning as used in the field of patent law.
In the claims, as well as in the specification above, all transitional phrases such as “comprising,” “including,” “carrying,” “having,” “containing,” “involving,” “holding,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases “consisting of and “consisting essentially of shall be closed or semi-closed transitional phrases, respectively.
The terms “amino acid” refer to a molecule containing both an amino group and a carboxyl group bound to a carbon which is designated the a-carbon. Suitable amino acids include, without limitation, both the D- and L-isomers of the naturally-occurring amino acids, as well as non-naturally occurring amino acids prepared by organic synthesis or other metabolic routes. In some embodiments, a single “amino acid” might have multiple sidechain moieties, as available per an extended aliphatic or aromatic backbone scaffold. Unless the context specifically indicates otherwise, the term amino acid, as used herein, is intended to include amino acid analogs including non-natural analogs.
The terms “exogenous gene” means a nucleic acid that has been recombinantly introduced into a cell, which encodes the synthesis of RNA and/or protein. In some embodiments, the exogenous gene is introduced by transformation. In some embodiments, the exogenous gene is introduced into the cell by electroporation. A transformed cell may be referred to as a recombinant cell, into which additional exogenous gene(s) may be introduced. The exogenous gene put into the host species may be taken from a different species (this is called heterologous), or it may naturally occur within the same species (this is homologous as defined below). Therefore, exogenous genes subsume homologous genes that are integrated within or introduced to regions of the genome, episome, or plasmid that differ from the locations where the gene naturally occurs. Multiple copies of the exogenous gene may be introduced into the cell. An exogenous gene may be present in more than one copy within the host cell or transformed cell. In some embodiments, the microorganism comprises between and including 1 and 10,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 1,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 10,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 1,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 500 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the exogenous gene is maintained by a cell as an insertion into the genome or as an episomal molecule. In some embodiments, the microorganism comprises no more than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, or 1000 copies of the one or more nucleic acids that encode one or more exogenous proteins.
The terms “functional fragment” means any portion of a polypeptide or nucleic acid sequence from which the respective full-length polypeptide or nucleic acid relates that is of a sufficient length and has a sufficient structure to confer a biological affect that is similar or substantially similar to the full-length polypeptide or nucleic acid upon which the fragment is based. In some embodiments, a functional fragment is a portion of a full-length or wild-type nucleic acid sequence that encodes any one of the nucleic acid sequences disclosed herein, and said portion encodes a polypeptide of a certain length and/or structure that is less than full-length but encodes a domain that still biologically functional as compared to the full-length or wild-type protein. In some embodiments, the functional fragment may have a reduced biological activity, about equivalent biological activity, or an enhanced biological activity as compared to the wild-type or full-length polypeptide sequence upon which the fragment is based. In some embodiments, the functional fragment is derived from the sequence of an organism, such as a human. In such embodiments, the functional fragment may retain 99%, 98%, 97%, 96%, 95%, 94%, 93%, 92%, 91%, or 90% sequence identity to the wild-type human sequence upon which the sequence is derived. In some embodiments, the functional fragment may retain 85%, 80%, 75%, 70%, 65%, or 60% sequence homology to the wild-type sequence upon which the sequence is derived. The present invention also comprises functional fragments of nucleotide sequences that encode a polypeptide capable of enzymatic activity, substrate activity, polarization activity, toxin activity, or antidote to toxin activity as disclosed herein in an animal. In some embodiments, the functional fragment are DNA or amino acid fragments selected from at least one of the various encoding nucleotide sequences of the present invention, including SEQ ID NO: 1, 7, 5, 6, 4, 2, or 3 and can be any of the following described DNA fragments, as it applies to the specific encoding nucleic acid sequence provided herein. In some embodiments, DNA fragments can comprise 30 or more, 45 or more, 60 or more, 75 or more, 90 or more, 120 or more, 150 or more, 180 or more, 210 or more, 240 or more, 270 or more, 300 or more, 360 or more, 420 or more, 480 or more, 540 or more, 600 or more, 660 or more, 720 or more, 780 or more, 840 or more, 900 or more, 960 or more, 1020 or more, 1080 or more, 1140 or more, 1200 or more, 1260 or more, 1320 or more, 1380 or more, 1440 or more, 1500 or more, 1560 or more, 1620 or more, 1680 or more, or 1740 or more, 1800 or more, 2000 or more, 2100 or more, 2200 or more, 2300 or more, 2400 or more, 2500 or more, 2600 or more, 2700 or more, 2800 or more, 2900 or more, 3000 or more, 4000 or more, 4500 or more, 5000 or more, 5500 or more, 6000 or more, 6500 or more, 7000 or more, 7500 or more, 8000 or more, 8500 or more, 9000 or more, 9500 or more, 10000 or more, 10100 or more nucleotides. In some embodiments, DNA fragments can comprise coding sequences for accessory proteins such as known ligands to tumor associated antigens expressed on the surface of tumor cells. In some embodiments, DNA fragments can comprise fewer than 60, fewer than 75, fewer than 90, fewer than 120, fewer than 150, fewer than 180, fewer than 210, fewer than 240, fewer than 270, fewer than 300, fewer than 360, fewer than 420, fewer than 480, fewer than 540, fewer than 600, fewer than 660, fewer than 720, fewer than 780, fewer than 840, fewer than 900, fewer than 960, fewer than 1020, fewer than 1080, fewer than 1140, fewer than 1200, fewer than 1260, fewer than 1320, fewer than 1380, fewer than 1440, fewer than 1500, fewer than 1560, fewer than 1620, fewer than 1680, or fewer than 1740, fewer than 1800, fewer than 1900, fewer than 2000, fewer than 2100, fewer than 2200, fewer than 2300, fewer than 2400, fewer than 2500, fewer than 2600, fewer than 2700, fewer than 2800, fewer than 2900, fewer than 3000, fewer than 4000, fewer than 5000, fewer than 6000, fewer than 7000, fewer than 8000, fewer than 9000, or fewer than 10000 nucleotides. In some embodiments, the functional fragments are nucleic acid fragments of SEQ ID NO:1 and include one or more nucleic acid derivatives. In some embodiments, the functional fragments are nucleic acid fragments of SEQ ID NO: 1, 2, 3, 7 and include more than about 5, 10, 15, 20, 25, or 30 nucleic acid derivatives.
The terms “hyperproliferative disorder” refer to a disorder characterized by abnormal proliferation, abnormal growth, abnormal senescence, abnormal quiescence, or abnormal removal of cells any or in an organism, and includes include hyperplasias, neoplasias, cancer, fibroproliferative disorders (such as involving connective tissues, as well as other disorders characterized by fibrosis, including for example, rheumatoid arthritis, insulin dependent diabetes mellitus, glomerulonephritis, cirrhosis, and scleroderma), smooth muscle proliferative disorders (such as atherosclerosis and restinosis), chronic inflammation, and epithelial cell proliferative disorders (for example, psoriasis; keratosis; acne; comedogenic lesions; verracous lesions such as verruca plana, plantar warts, verruca acuminata, and other verruciform lesions marked by proliferation of epithelial cells; folliculitis and pseudofolliculitis; keratoacanthoma; callosities; Darier's disease; ichthyosis; lichen planus; molluscous contagiosum; melasma; Fordyce disease; and keloids or hypertrophic scars). In some embodiments, the hyperproliferative disease is a cancer derived from the gastrointestinal tract or urinary system. In some embodiments, a hyperproliferative disease is a cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the term hyperproliferative disease is a cancer chosen from: lung cancer, bone cancer, CMML, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer, cancer of the anal region, stomach cancer, colon cancer, breast cancer, testicular, gynecologic tumors (e.g., uterine sarcomas, carcinoma of the fallopian tubes, carcinoma of the endometrium, carcinoma of the cervix, carcinoma of the vagina or carcinoma of the vulva), Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system (e.g., cancer of the thyroid, parathyroid or adrenal glands), sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphomas, cancer of the bladder, cancer of the kidney or ureter (e.g., renal cell carcinoma, carcinoma of the renal pelvis), or neoplasms of the central nervous system (e.g., primary CNS lymphoma, spinal axis tumors, brain stem gliomas or pituitary adenomas).
As used herein, the term “genetic construct” refers to the DNA or RNA molecules that comprise a nucleotide sequence that encodes one or more of the polypeptides. In some embodiments, the genetic construct encodes one or more of the polypeptides described herein. In some embodiments, the nucleotide sequence that encodes a one or more of the polypeptides described herein, or coding sequence, includes initiation and termination signals operably linked to regulatory elements including a bacterial promoter and polyadenylation signal capable of directing expression in the cells of the bacteria in which the nucleic acid molecule is transformed.
The terms “effective amount” refers to an amount of a compound, material, or composition, as described herein effective to achieve a particular biological result such as, but not limited to, biological results disclosed, described, or exemplified herein. Such results may include, but are not limited to colonization of a tumor by administration of a composition disclosed herein, or production of an amount of a therapeutic agent, portion thereof, or a reaction product after exposure of the substrate with an enzyme such that the presence, absence or quantity of substrate, portion thereof, or a reaction product determined by any means suitable in the art. In some embodiments, the biological result is an amount of a substrate, portion thereof, or a reaction product after exposure of the substrate with an enzyme such that the presence, absence or quantity of substrate, portion thereof, or a reaction product determined by visual inspection of urine excreted by a subject administered any one or more compositions disclosed herein. The effective amount of the composition may be dependent on any number of variables, including without limitation, the species, breed, size, height, weight, age, overall health of the subject, the type of formulation, the mode or manner of administration, the type and/or severity of the particular condition being treated.
The terms “electroporation,” “electro-permeabilization,” or “electro-kinetic enhancement” (“EP”) as used interchangeably herein refer to the use of a transmembrane electric field pulse to induce microscopic pathways (pores) in a bio-membrane; their presence allows biomolecules such as plasmids, oligonucleotides, siRNA, drugs, ions, and water to pass from one side of the cellular membrane to the other.
As used herein, the term “expressible form” refers to gene constructs that contain the necessary regulatory elements operably linked to a coding sequence that encodes one or more proteins described herein, such that, when present in a transformed or transfected cell, the coding sequence will be expressed.
In some embodiments, the compositions, kits, methods comprise at least one non-pathogenic bacteria. As used herein, the term “non-pathogenic” refers to a bacteria that is not capable of causing a disease or disorder in an animal when administered to an animal, including a human. In some embodiments, the microorganism is incapable of causing a disease or disorder when administered to a mammal. In some embodiments, the microorganism is a non-pathogenic microorganism incapable of causing a disease or disorder when administered to a human or domesticated animal (such as a dog, cat, horse, sheep, cow, goat, pig, etc.). In some embodiments, the microorganism is non-pathogenic microorganism incapable of causing a disease or disorder when administered to a human. In some embodiments, the microorganism is non-pathogenic microorganism is chosen from any one of the bacterial species identified in Table 1. In some embodiments, the non-pathogenic microorganism is not at least one of species listed on Table 1. In some embodiments, the non-pathogenic microorganism is an attenuated bacterial strain. In some embodiments, the non-pathogenic microorganism is an attenuated bacterial strain listed on Table 1. In some embodiments, the non-pathogenic microorganism is an attenuated bacterial strain genetically modified to silence, remove, or mutate a virulence factor.
The term “nucleic acid” refers to a molecule comprising two or more linked nucleotides. “Nucleic acid” and “nucleic acid molecule” are used interchangeably and refer to oligoribonucleotides as well as oligodeoxyribonucleotides. The terms also include polynucleosides (i.e., a polynucleotide minus a phosphate) and any other organic base containing nucleic acid. The organic bases include adenine, uracil, guanine, thymine, cytosine and inosine. The nucleic acids may be single or double stranded. The nucleic acid may be naturally or non-naturally occurring. Nucleic acids can be obtained from natural sources, or can be synthesized using a nucleic acid synthesizer (i.e., synthetic). Isolation of nucleic acids are routinely performed in the art and suitable methods can be found in standard molecular biology textbooks. (See, for example, Maniatis' Handbook of Molecular Biology.) The nucleic acid may be DNA or RNA, such as genomic DNA, mitochondrial DNA, mRNA, cDNA, rRNA, miRNA, PNA or LNA, or a combination thereof, as described herein. Non-naturally occurring nucleic acids such as bacterial artificial chromosomes (BACs) can also be used in accordance with some aspects of this invention.
Some aspects of this invention relate to the use of nucleic acid derivatives. The use of certain nucleic acid derivatives may increase the stability of the nucleic acids of the invention by preventing their digestion, particularly when they are exposed to biological samples that may contain nucleases. As used herein, a nucleic acid derivative is a non-naturally occurring nucleic acid or a unit thereof. Nucleic acid derivatives may contain non-naturally occurring elements such as non-naturally occurring nucleotides and non-naturally occurring backbone linkages. Nucleic acid derivatives according to some aspects of this invention may contain backbone modifications such as but not limited to phosphorothioate linkages, phosphodiester modified nucleic acids, combinations of phosphodiester and phosphorothioate nucleic acid, methylphosphonate, alkylphosphonates, phosphate esters, alkylphosphonothioates, phosphoramidates, carbamates, carbonates, phosphate triesters, acetamidates, carboxymethyl esters, methylphosphorothioate, phosphorodithioate, p-ethoxy, and combinations thereof. The backbone composition of the nucleic acids may be homogeneous or heterogeneous. Nucleic acid derivatives according to some aspects of this invention may contain substitutions or modifications in the sugars and/or bases. For example, some nucleic acid derivatives may include nucleic acids having backbone sugars which are covalently attached to low molecular weight organic groups other than a hydroxyl group at the 3′ position and other than a phosphate group at the 5′ position (e.g., an 2′-O-alkylated ribose group). Nucleic acid derivatives may include non-ribose sugars such as arabinose. Nucleic acid derivatives may contain substituted purines and pyrimidines such as C-5 propyne modified bases, 5-methylcytosine, 2-aminopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, hypoxanthine, 2-thiouracil and pseudoisocytosine. In some embodiments, a nucleic acid may comprise a peptide nucleic acid (PNA), a locked nucleic acid (LNA), DNA, RNA, or a co-nucleic acids of the above such as DNA-LNA co-nucleic acid.
As used herein the term “isolated nucleic acid molecule” refers to a nucleic acid that is not in its natural environment, for example a nucleic acid that has been (i) extracted and/or purified from a cell or microbe, for example, a bacteria or yeast, by methods known in the art, for example, by alkaline lysis of the host cell and subsequent purification of the nucleic acid, for example, by a silica adsorption procedure; (ii) amplified in vitro, for example, by polymerase chain reaction (PCR); (iii) recombinantly produced by cloning, for example, a nucleic acid cloned into an expression vector; (iv) fragmented and size separated, for example, by enzymatic digest in vitro or by shearing and subsequent gel separation; or (v) synthesized by, for example, chemical synthesis. In some embodiments, the term “isolated nucleic acid molecule” refers to (vi) an nucleic acid that is chemically markedly different from any naturally occurring nucleic acid. In some embodiments, an isolated nucleic acid can readily be manipulated by recombinant DNA techniques well known in the art.
Accordingly, a nucleic acid cloned into a vector, or a nucleic acid delivered to a host cell and integrated into the host genome is considered isolated but a nucleic acid in its native state in its natural host, for example, in the genome of the host, is not. An isolated nucleic acid may be substantially purified, but need not be. For example, a nucleic acid that is isolated within a cloning or expression vector is not pure in that it may comprise only a small percentage of the material in the cell in which it resides. Such a nucleic acid is isolated, however, as the term is used herein.
“Sequence homology” or “sequence identity” or “homolgous to” are used herein interchangeably for nucleotides and amino acids sequences determined using FASTA, BLAST and Gapped BLAST (Altschul et al., Nuc. Acids Res., 1997, 25, 3389, which is incorporated herein by reference in its entirety) and PAUP* 4,ObIO software (D. L. Swofford, Sinauer Associates, Massachusetts). Briefly, the BLAST algorithm, which stands for Basic Local Alignment Search Tool is suitable for determining sequence similarity (Altschul et al., J. Mol. Biol, 1990, 215, 403-410, which is incorporated herein by reference in its entirety). Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov). One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide sequences would occur by chance. For example, a nucleic acid is considered similar to another if the smallest sum probability in comparison of the test nucleic acid to the other nucleic acid is less than about 1, preferably less than about 0.1, more preferably less than about 0.01, and most preferably less than about 0.001. “Percentage of similarity” or percentage of sequence identity” can be calculated using PAUP* 4,ObIO software (D. L. Swofford, Sinauer Associates, Massachusetts). The average similarity of the consensus sequence is calculated compared to all sequences in the phylogenic tree. In some embodiments, the compositions disclosed herein comprise nucleic acid sequences that are at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% homologous to SEQ ID NO:1, SEQ ID NO: 5, SEQ ID NO: 6, and/or SEQ ID NO:7. In some embodiments, the compositions disclosed herein comprise nucleic acid or amino acid sequences that are at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% homologous to SEQ ID NOS:1-7.
As used herein, “conservative” amino acid substitutions may be defined as set out in Tables A, B, or C below. In some embodiments, the at least one bacterial cell of the present invention comprises any of the nucleic acid sequences or amino acid sequences disclosed herein with one or more conservative amino acid or nucleic acid mutations. The mutation may include those wherein conservative substitutions have been introduced by modification of polynucleotides encoding polypeptides of the invention. Amino acids can be classified according to physical properties and contribution to secondary and tertiary protein structure. A conservative substitution is recognized in the art as a substitution of one amino acid for another amino acid that has similar properties. Exemplary conservative substitutions are set out in Table A.
Alternately, conservative amino acids can be grouped as described in Lehninger, (Biochemistry, Second Edition; Worth Publishers, Inc. NY, N.Y. (1975), pp. 71-77) as set forth in Table B.
Alternately, exemplary conservative substitutions are set out in Table C.
It should be understood that the polypeptides comprising polypeptide sequences associated with the extracellular matrix described herein are intended to include polypeptides bearing one or more insertions, deletions, or substitutions, or any combination thereof, of amino acid residues as well as modifications other than insertions, deletions, or substitutions of amino acid residues.
The term “subject” is used throughout the specification to describe an animal to whom treatment with the compositions according to the present invention is provided or administered. For treatment of those conditions which are specific for a specific subject, such as a human being or such as a mammal, the term “patient” may be interchangeably used. In some instances in the description of the present invention, the term “patient” will refer to human patients. In some embodiments, the subject may be a mammal to whom the present invention is provided or administered. In some embodiments, the subject may be a domesticated mammal to whom the present invention is provided or administered such as a horse, dog, cat, pig, cow, goat, sheep, llama, or other non-human animal. In some embodiments, the subject is non-human. In some embodiments, the subject is a mammal suspected of having a hyperproliferative disorder. In some embodiments, the subject is an animal diagnosed with cancer and suspected of having cancer.
As used herein, the term “therapeutic agent” is any chemical compound, amino acid sequence, radioisotope, or combination thereof that can be used to reduce symptom burden or correct dysfunctional components of cellular pathways responsible for disease or improve a subject's prognosis or kill a cancer cell or cells. In some embodiments, the therapeutic agent treats or prevents metastatic cancer cell growth. In some embodiments, the therapeutic agent is an amino acid sequence that kills cancer cells or cells associated with a hyperproliferative disease. In some embodiments, the therapeutic agent is an amino acid sequence that enhances the ability of another molecule present in a particular microenvironment to kill cancer cells or cells associated with a hyperproliferative disease. In some embodiments, the therapeutic agent is an amino acid sequence that contains a cellular death domain and/or is a cellular toxin. In some embodiments, the cellular toxin in CDD or an amino acid analog thereof that is 70, 85 80, 85, 90, 95, 96, 97, 98, or 99% homolgous to CDD. In some embodiments, the therapeutic agent comprises a first and second moiety wherein the first moiety comprises one or more amino acid sequences that are cellular toxins and the second moiety comprises one or more targeting sequences. A targeting sequence for purposes of this invention is an amino acid sequence that directs delivery of a therapeutic agent to a target cell or microenvironment within a cell. In some embodiments, the therapeutic agent comprises a linker that fuses the first and second moieties. In some embodiments, the targeting moiety or targeting sequence comprises an amino acid sequence 70, 85 80, 85, 90, 95, 96, 97, 98, or 99% homolgous to iRGD or like proteins. In some embodiments, the therapeutic agent can kill or enhance killing of colorectal cancer cells and/or ovarian cancer cells. In some embodiments, the at least one bacterial cell is administered sequentially, simultaneously, or subsequently to dosing with one or more of the following chemotherapeutic agents:
In some embodiments, pharmaceutical compositions of the present invention comprise at least one bacterial cell disclosed herein, a pharmaceutical acceptable carrier, and at least one additional therapeutic agent. Combination products are contemplated by this invention. Many therapeutic agents are known. For instance, in some embodiments, the pharmaceutical compositions of the claimed invention comprise at least one additional therapeutic agent comprising any of the agents disclosed in U.S. Pat. Nos. 8,343,498, 6,849,272, 8,257,714, 8,466,110, 7,655,444, 6,693,112, 6,428,968, and 5,633,274, each of which are incorporated herein by reference in their entireties.
As used herein, the term “promoter” means at least a first nucleic acid sequence that regulates or mediates transcription of a second nucleic acid sequence. In some embodiments, the second nucleic acid sequence encodes a cellular toxin or an amino acid sequence that enhances cellular toxicity of a microenvironment in the absence or presence of a substance being secreted by a cell. In some embodiments, the second nucleic acid sequence encodes a cellular toxin or an amino acid sequence that enhances cellular toxicity of a microenvironment in the absence or presence of a substance being secreted by a cancer cell or cell associated with a hyperproliferative disorder. For purposes of the invention, a promoter may comprise nucleic acid sequences near the start site of transcription that are required for proper function of the promoter. As an example, a TATA element for a promoter of polymerase II type. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 5,000 base pairs from the initiation site. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 10,000 base pairs or more from the initiation site. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 1,000 base pairs from the initiation site. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 500 base pairs from the initiation site. The term “inducible promoter” refers to an operable linkage between a promoter and a nucleic acid sequence, whereby the promoter mediates the nucleic acid transcription in the presence or absence of at least one specific stimulus. In some embodiments, the inducible promoter mediates transcription of a nucleic acid sequence in the presence or absence of at least one, two, three, four, or five or more stimuli. In some embodiments, the one or more stimuli are not external stimuli in reference to the body of the subject to whom the at least one bacterial cell or compositions disclosed herein are administered. In some embodiments, the one or more stimuli are natural stimuli secreted or presented by the subject to whom the disclosed compositions or at least one bacterial cells are administered. In some embodiments, the at least one stimuli do not comprise light or a chemical molecule administered to the body of a subject before, simultaneously with, or after administration of the disclosed compositions or at least one bacterial cell. In some embodiments, the at least one stimuli is not administered to the body of a subject before, simultaneously with, or after administration of the disclosed compositions or at least one bacterial cell, but is a product or molecule found in the subject of a patient. In some embodiments, the none of the stimuli are administered to the body of a subject before, simultaneously with, or after administration of the disclosed compositions or at least one bacterial cell, but rather the stimulus is a product or molecule found in the subject of a patient. In some embodiments, the only stimulus of the promoter is presence of a certain density of bacteria found in the subject of a patient. In some embodiments, the only stimulus of the promoter is presence of a certain density of bacteria found in the subject of a patient.
In some embodiments, the inducible promoter mediates transcription of a nucleic acid that enhances cellular toxicity either by encoding an amino acid that is toxic to a cell or encoding an amino acid sequence that increases the toxicity of a microenvironment in which the at least one bacterial cell colonizes and grows. In some embodiments, the inducible promoter mediates transcription of a nucleic acid that enhances cellular toxicity either by encoding an amino acid that is toxic to a cell or encoding an amino acid sequence that increases the toxicity of a microenvironment in the absence of presence of a cellular factor natively produced by the body of the subject. In some embodiments, the at least one specific stimulus is a certain density of bacteria carrying the inducible promoter in a tissue of a subject. In some embodiments, the at least one specific stimulus is the presence of absence of a cofactor. In some embodiments, the at least one specific stimulus is the presence of absence of a cofactor that is a tumor associated antigen. In some embodiments, the inducible promoter does not require any external stimulus other than the presence of a certain density of bacteria within a cofactor which can be added to the environment of the composition comprising the nucleic acid sequence that contains the inducible promoter. An “operable linkage” refers to an operative connection between nucleic acid sequences, such as for example between a control sequence (e.g. a promoter) and another nucleic acid sequence that codes for a protein i.e. a coding sequence. If a promoter can regulate transcription of an exogenous nucleic acid sequence then it is in operable linkage with the gene.
Bacterial Strains
The invention relates to bacterial cells comprising any one or more of the nucleic acid sequences of the disclosed herein. In some embodiments, the at least one bacterial cell comprises one or combination of any two or more bacterial species chosen from Table 1. In some embodiments, the bacteria are non-pathogenic. In some embodiments, the bacteria are attenuated. In some embodiments, the bacteria are attenuate and non-pathogenic. One of ordinary skill in the art would know how to attenuate pathogenic bacteria to create non-pathogenic bacteria. In some embodiments, the bacteria are attenuated by removing, knocking out, or mutating a virulence gene such as altering genetic components of the bacterial secretion system. In some embodiments, at least one bacterial cell is a Machl (E. coli strain), E. coli Nissle, E. coli DH5alpha, or S. Typhimurium (strains SL7207, ELH430, ELH1301). In other embodiments, the bacterial strain is chosen from: Bifidobacterium, Vibrio fischeri, and Bifidolongum.
In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence that encodes a therapeutic amino acid sequence or functional fragment thereof operably linked to a second nucleic acid sequence that comprise one or more inducible promoters or functional fragments thereof operably linked to the first nucleic acid sequence, wherein the inducible promoter or functional fragment thereof mediates the non-constitutive expression of the first nucleic acid sequence. In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence that encodes a therapeutic amino acid sequence or functional fragment thereof operably linked to a second nucleic acid sequence encoding one or more inducible promoters or functional fragments thereof, wherein the inducible promoter or functional fragment thereof is a non-constitutive promoter that responds only to a single stimulus. In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence that encodes a therapeutic amino acid sequence or functional fragment thereof operably linked to a second nucleic acid sequence encoding one or more inducible promoters or functional fragments thereof, wherein the inducible promoter or functional fragment thereof is a non-constitutive promoter that mediates expression of the first nucleic acid sequence only in the presence or absence of a certain density of a bacterial cells comprising the first and second nucleic acid sequences.
In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence encoding an death domain or functional fragment thereof operably linked to a second nucleic acid sequence comprising one or more inducible promoters or functional fragments thereof, wherein the inducible promoter or functional fragments thereof are non-constitutive promoter. In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence encoding an death domain or functional fragment thereof operably linked to a second nucleic acid sequence encoding one or more inducible promoters or functional fragments thereof, wherein the inducible promoter is a non-constitutive promoter and responds to the density of bacteria in a tissue.
Some embodiments of the invention further comprise third nucleic acid sequence encoding a bacterial toxin or functional fragment thereof, and a fourth nucleic acid sequence encoding an antidote to the bacterial toxin. In order to manufacture or produce such a non-pathogenic microorganism, one of ordinary skill in the art would contact the microorganism with a composition comprising each of the first, second, third, or fourth nucleic acid sequences. Methods to deliver expression vectors or expression constructs into microbes, for example, into non-pathogenic bacteria, are well known to those of skill in the art. Nucleic acids, including expression vectors, can be delivered to prokaryotic microbes by various methods well known to those of skill in the relevant biological arts. Methods for the delivery of nucleic acids to a microbe in accordance to some aspects of this invention, include, but are not limited to, different chemical, electrochemical and biological approaches, for example, heat shock transformation, electroporation, transfection, for example liposome-mediated transfection, DEAE-Dextran-mediated transfection or calcium phosphate transfection. In some embodiments, a nucleic acid construct, for example an expression construct comprising any combination of the first, second, third, and/or fourth nucleic acid sequences disclosed herein, is introduced into the host microbe using a vehicle, or vector, for transferring genetic material. Vectors for transferring genetic material to microbes are well known to those of skill in the art and include, for example, plasmids, artificial chromosomes, and viral vectors. Methods for the construction of nucleic acid constructs, including expression constructs comprising constitutive or inducible heterologous promoters, knockout and knockdown constructs, as well as methods and vectors for the delivery of a nucleic acid or nucleic acid construct to a microbe are well known to those of skill in the art, and are described, for example, in J. Sambrook and D. Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press; 3rd edition (Jan. 15, 2001); David C. Amberg, Daniel J. Burke; and Jeffrey N. Strathern, Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, Cold Spring Harbor Laboratory Press (April 2005); John N. Abelson, Melvin I. Simon, Christine Guthrie, and Gerald R. Fink, Guide to Yeast Genetics and Molecular Biology, Part A, Volume 194 (Methods in Enzymology Series, 194), Academic Press (Mar. 11, 2004); Christine Guthrie and Gerald R. Fink, Guide to Yeast Genetics and Molecular and Cell Biology, Part B, Volume 350 (Methods in Enzymology, Vol 350), Academic Press; 1st edition (Jul. 2, 2002); Gregory N. Stephanopoulos, Aristos A. Aristidou and Jens Nielsen, Metabolic Engineering: Principles and Methodologies, Academic Press; 1 edition (Oct. 16, 1998); and Christina Smolke, The Metabolic Pathway Engineering Handbook: Fundamentals, CRC Press; 1 edition (Jul. 28, 2009), all of which are incorporated by reference herein in their entireties.
Some aspects of this invention relate to cultures of genetically modified microbes provided herein. In some embodiments, the culture comprises a genetically modified microbe provided herein and a medium, for example, a liquid medium. In some embodiments, the culture comprises a genetically modified microbe provided herein and a carbon source, for example, a carbohydrate source, or an organic acid or salt thereof. In some embodiments, the culture comprises a genetically modified microbe provided herein and a salt and/or buffer establishing conditions of salinity, osmolarity, and pH, that are amenable to survival, growth, and/or catalytic activity of the encoded enzyme. In some embodiments, the culture comprises an additional component, for example, an additive. Non-limiting examples of additives are nutrients, amino acids, albumin, growth factors, enzyme inhibitors (for example protease inhibitors), fatty acids, lipids, hormones (e.g., dexamethasone and gibberellic acid), trace elements, inorganic compounds (e.g., reducing agents, such as manganese), redox-regulators (e.g., antioxidants), stabilizing agents (e.g., dimethylsulfoxide), polyethylene glycol, polyvinylpyrrolidone (PVP), gelatin, antibiotics (e.g., Brefeldin A), salts (e.g., NaCl), chelating agents (e.g., EDTA, EGTA), and enzymes (e.g., cellulase, dispase, hyaluronidase, or DNase). In some embodiments, the culture may comprise a drug inducing or inhibiting transcription from a conditional or inducible promoter, for example doxicycline, tetracycline, tamoxifen, IPTG, hormones, or metal ions. While the specific culture conditions, for example, the concentration of the carbon source, will depend upon the respective engineered microorganism to be cultured, general methods and culture conditions for the generation of microbial cultures are well known to those of skill in the art, and are described, for example, in J. Sambrook and D. Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press; 3rd edition (Jan. 15, 2001); David C. Amberg, Daniel J. Burke; and Jeffrey N. Strathern, Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, Cold Spring Harbor Laboratory Press (April 2005); John N. Abelson, Melvin I. Simon, Christine Guthrie, and Gerald R. Fink, Guide to Yeast Genetics and Molecular Biology, Part A, Volume 194 (Methods in Enzymology Series, 194), Academic Press (Mar. 11, 2004), all of which are incorporated by reference herein.
In some embodiments, the genetically modified non-pathogenic microbe or microorganism exhibits a growth advantage over wild type microbes of the same kind and/or over other microbes, for example, microbes commonly found to contaminate microbial cultures for scaling up production of cultures to large volumes. In some embodiments, the growth and/or proliferation advantage of an engineered microbe provided by aspects of this invention translates into the possibility of using non-sterile culturing and fermentation conditions for production, because the problem of culture overgrowth by contaminating microbes is mitigated or completely abolished. In some embodiments, an engineered microbe provided by aspects of this invention is cultured under non-sterile conditions. For example, in some embodiments, non-sterilized feedstock, non-sterilized culture media, non-sterilized supplements, or a non-sterilized bioreactor (e.g. an open reactor under non-sterile conditions) is used for microorganism division.
A variety of different microbes can be genetically modified according to some aspects of this invention and used for scale-up and/or isolation for eventual animal ingestion, for example, various strains of non-pathogenic E. Coli. In some embodiments, the invention provides for a composition comprising one or a combination of non-pathogenic bacteria chosen from: probiotic bacteria is chosen from Salmonella spp., Escherichia spp., Firmicutes spp., Bacteroidetes spp., Lactobacillus spp., Bifidobacteria spp., or Adalopholus spp. In some embodiments, the probiotic is selected from Lactobacillus, Bifidobacteria, and Acidopholus. In some embodiments, the bacteria is harvested from a human or animal sample and transformed as described herein, with our system. The samples may be from stool samples (probiotics) or human/mouse tumor samples (bacteria that have potential to be very tumor selective). In some embodiments, the non-pathogenic microorganism is E. coli Nissle 1917 (EcN). In some embodiments, the non-pathogenic microorganism is a strain of E. coli but not the Nissle 1917 (EcN). In some embodiments, the compositions, pharmaceutical compositions, kits or cells disclosed herein comprise at least one E. coli strain Machl. Expanding upon this we have shown the E. coli Nissle, E. coli DH5alpha, and S. Typhimurium. In some embodiments, the compositions, pharmaceutical compositions, kits or cells disclosed herein comprise at least one bacterial cell chosen from SL7207, ELH430, and ELH130 strains of S. Typhimurium. In some embodiments, the compositions, pharmaceutical compositions, kits or cells disclosed herein comprise at least one bacterial cell chosen from Salmonella spp., Escherichia spp., Firmicutes spp., Bacteroidetes spp., Lactobacillus spp., Bifidobacteria spp., or Acidopholus spp.
The present invention relates to compositions comprising any one or combination of non-pathogenic bacteria disclosed herein wherein at least one of the bacteria comprises a first, second, third, and/or fourth nucleic acid sequences disclosed herein either alone or in combination. In some embodiments, the invention relates to compositions comprising any one or combination of non-pathogenic bacteria disclosed herein wherein at least one of the bacteria comprises a nucleotide sequence encoding a mutated virulence factor. For instance, in some embodiments, the non-pathogenic microorganism comprises a mutation in its Type I, II, III, IV, V, or VI secretion system which does not allow transport of host toxins and/or host immunogenic proteins out of the cell.
In some embodiments, the invention relates to a system comprising at least one of the bacterial cells disclosed herein and bacterial growth media. In some embodiments, the invention relates to a system comprising at least one of the bacterial cells disclosed herein and a cell culture vessel or biorcactor.
In some embodiments, the invention relates to a system comprising at least one of the bacterial cells disclosed herein, bacterial growth media, and a cell culture vessel or bioreactor. fermentation processes for large-scale microbe cell division may be carried out in bioreactors, isolated and then resuspended in an amount or dosage form disclosed herein. As used herein, the terms “bioreactor” and “fermentor”, which are interchangeably used, refer to an enclosure, or partial enclosure, in which a biological and/or chemical reaction takes place, at least part of which involves a living organism or part of a living organism. A “large-scale bioreactor” or “industrial-scale bioreactor” is a bioreactor that is used to generate large volumes of non-pathogenic bacteria for large scale isolation. Large scale bioreactors typically have volumes in the range of liters, hundreds of liters, thousands of liters, or more.
Other examples of bacteria that can be modified for use in the invention include food-grade bacterial strains. In some embodiments, the non-pathogenic bacteria is chosen from the bacterials strains identified in Humaran et al., Microbial Cell Factories 2011, 10(Suppl 1):S4; Shrivastava et al., PlosOne, August 2008, Volume 3, Issue 8: e2955; and T. Danino et al., ACS Synth. Biol. 2012, 1, 465-470, each of which are incorporated by reference in their entireties.
The invention relates to compositions comprising any of the bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an amount effective to colonize a tumor. The invention relates to compositions comprising any of the bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an amount effective to colonize a tumor upon administration of the compositions or bacteria to the subject in need thereof. The invention relates to compositions comprising any of the bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an effective amount to colonize a tumor and adequate produce enzyme or substrate in quantities detectable in urine. The invention relates to compositions comprising any of the non-pathogenic bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an effective amount to colonize a tumor and adequate produce enzyme or substrate in quantities detectable in urine by visual inspection. The invention relates to compositions comprising any of the non-pathogenic bacteria disclosed herein wherein the compositions are in a solid or liquid dosage form. In addition to the compositions disclosed in either solid or liquid form, the formulations and compositions of the present invention may also contain optional ingredients to enhance the characteristics of the solid dosage form, maintain the integrity of bacteria (in dried, lyophilized, dormant or sporulated forms) during the formulation process, and/or enhance the safety of the formulation. Any additional components may be compatible with the other ingredients in the formulations of the invention, in particular the active ingredients, and may be inert. If inert, the additional component does not adversely affect the osmolarity, osmolality, or isotoncity of the formulations or interfere, to a measureable degree, with the biological function of the non-pathogenic microorganism. Additional optional ingredients that may be used in the formulations of the invention include, for example, coatings, diluents, binders, glidants, lubricants, colors, disintegrants, flavors, sweeteners, polymers or waxes.
Non-limiting examples of diluents include various types of starch, cellulose, crystalline cellulose, microcrystalline cellulose, lactose, fructose, sucrose, mannitol or other sugar alcohols, kaolin, calcium phosphate or sulfate, inorganic salts such as sodium chloride and powdered sugar. Powdered cellulose derivatives are also useful. In some embodiments of the invention, the formulation does not include a diluent.
Lubricants, for example, may be included in the formulations of the invention. Such lubricants include, but are not limited to, magnesium stearate, potassium stearate, talc, stearic acid, sodium lauryl sulphate, and paraffin. In some embodiments of the invention, the colonic purgative formulation further comprises magnesium stearate. Lubricants serve to facilitate the manufacturing of a solid dosage form. In some embodiments of the invention, the formulation does not comprise a lubricant.
Additional suitable ingredients also include, but are not limited to, carriers, such as sodium citrate and dicalcium phosphate; fillers or extenders, such as stearates, silicas, gypsum, starches, lactose, sucrose, glucose, mannitol, talc, and silicic acid; binders, such as hydroxypropyl methylcellulose, hydroxymethyl-cellulose, alginates, gelatin, polyvinyl pyrrolidone, sucrose, and acacia; humectants, such as glycerol; disintegrating agents, such as agar, calcium carbonate, potato and tapioca starch, alginic acid, certain silicates, colloidal silicon dioxide, sodium starch glycolate, crospovidone, and sodium carbonate; solution retarding agents, such as paraffin; absorption accelerators, such as quaternary ammonium compounds; wetting agents, such as cetyl alcohol and glycerol monostearate; absorbents, such as kaolin and bentonite clay; stabilizers, such as fumaric acid; coloring agents; buffering agents; dispersing agents; preservatives; organic acids; and organic bases.
In some embodiments of the instant invention, the tablet or capsules may also include inert dispersal agents which will facilitate dissolution of the a solid dosage form of the non-pathogenic bacteria in the stomach of the patient. Preferably, the dispersal agent is a pharmaceutically acceptable dispersant and is one which also produces no appreciable osmotic effects. Examples of acceptable dispersants include microcrystalline cellulose (which is also useful as a compacting agent) and anhydrous lactose. In some embodiments, the dispersal agent is AC-DI-SOL, a cross-linked starch.
In some embodiments of the present invention, the formulation or composition may also include a buffering agent to minimize any acid imbalance which may accompany ingestion of the compositions disclosed herein. Suitable buffering agents include magnesium hydroxide, aluminum hydroxide, calcium carbonate and magnesium carbonate. In some embodiments, the formulation does not include a buffering agent.
In some embodiments of the invention, an additional component in the formulations of the invention may function to maintain the electrolyte balance in a subject after ingestion of a liquid dosage form of the compositions disclosed herein. For example, formulations of the invention may further comprise calcium, phosphate, potassium, magnesium, other anions, or salts thereof.
In some embodiments, the composition comprises at least one bacterium that comprises stably transfected nucleic acid molecules. In some embodiment, the nucleic acid molecules are DNA or RNA. In some embodiments, the nucleic acid molecules are DNA plasmids.
Culture System
The invention generally relates to a culture system that comprises at least one culture vessel comprising any one or combination of bacteria or compositions disclosed herein. Microbial culturing in the present invention is performed both for the sake of implementing genetic modifications, and for scaled up production of the bacteria disclosed herein. In some embodiments, the invention relates to the method of culturing at least one bacterium disclosed herein comprising inoculating a growth medium with the at least one bacterium disclosed herein.
Microbial culturing with the aim of genetic manipulation is generally performed at a small benchtop scale and often under conditions that select for genetically modified traits. Microbial culturing aimed at the commercial production of bacteria suitable for use in a subject can be performed in bioreactors at much greater scale (e.g., 1 L, 10 L, 500 L, 1,000 L 5,000 L, 10,000 L, 50,000 L, 100,000 L bioreactor volumes and higher). In certain embodiments the bacteria of the present invention are grown in a liquid media inside a bioreactor using the methods of the invention. In some embodiments of the present invention steel fermentors 50,000 liter and greater in volume are utilized. In some embodiments of the present invention egg-shape or cylindrical digestrors 3,000,000 liters and greater in volume are utilized. In some embodiments, the bioreactor comprising the microorganism does not allow light to penetrate its interior.
The bioreactor or fermentor is used to culture cells through the various phases of their physiological cycle. A bioreactor is utilized for the cultivation of cells, which may be maintained at particular phases in their growth curve. Generally the control of growth conditions including dissolved carbon dioxide, oxygen, and other gases such as hydrogen, as well as other dissolved nutrients, trace elements, temperature and pH are facilitated in a bioreactor.
Nutrient media as well as gases can be added to the bioreactor as either a batch addition, or periodically, or in response to a detected depletion or programmed set point, or continuously over the period the culture is grown and/or maintained. For certain embodiments, the bioreactor at inoculation is filled with a starting batch of nutrient media and/or gases at the beginning of growth, and no additional nutrient media and/or gases is added after inoculation. For certain embodiments, nutrient media and/or gases are added periodically after inoculation. For certain embodiments, nutrient media and/or gas is added after inoculation in response to a detected depletion of nutrient and/or gas. For certain embodiments, nutrient media and/or gas is added continuously after inoculation.
In some embodiments, the bioreactors comprise a mechanisms to mix of the nutrient media that include but are not limited to spinning stir bars, blades, impellers, or turbines, spinning, rocking, or turning vessels, gas lifts and sparging. The culture media may be mixed continuously or intermittently.
The ports that are standard in bioreactors may be utilized to deliver, or withdraw, gases, liquids, solids, and/or slurries, into the bioreactor vessel enclosing the microbes of the present invention. Many bioreactors have multiple ports for different purposes (e.g. ports for media addition, gas addition, probes for pH and DO, sampling), and a given port may be used for various purposes during the course of a fermentation run. As an example, a port might be used to add nutrient media to the bioreactor at one point in time and at another time might be used for sampling. Preferably, the multiple use of a sampling port can be performed without introducing contamination or invasive species into the growth environment. A valve or other actuator enabling control of the sample flow or continuous sampling can be provided to a sampling port. For certain embodiments the bioreactors are equipped with at least one port suitable for culture inoculation that can additionally serve other uses including the addition of media or gas. Bioreactors ports enable control of the gas composition and flow rate into the culture environment. For example the ports can be used as gas inlets into the bioreactor through which gases are pumped. For some embodiments gases that may be pumped into a bioreactor include hydrogen gas, CO2, air, air/CO2 mixtures, ammonia, nitrogen, noble gases, such as argon, as well as other gases. Raising the gas flow rate into a bioreactor can enhance mixing of the culture and produce turbulence if the gas inlet is positioned under the surface of the liquid media such that gas bubbles or sparges up through the media. In some embodiments, a bioreactor comprises gas outlet ports for gas escape and pressure release. In some embodiments, gas inlets and outlets are preferably equipped with check valves to prevent gas backflow.
The nucleic acid sequences of the present invention may be components of one, two or more, three or more, four or more than three different plasmid molecules. Each individual nucleica acid sequence may reside on its own nucleic acid molecule or plasmid. In some embodiments, each exogenous nucleic acid resides on a single DNA plasmid. In some embodiments, the nucleic acid sequence that is an inducible promoter comprises at least one, two, three, four or more exogenous nucleic acid sequences whose presence individually or in combination control the expression of one or more coding sequences. In some embodiments, the coding sequence is a therapeutic agent, cell death amino acid sequence, cancer cell targeting sequence (e.g. ligand of a tumor associated antigen), or a selectable marker or marker amino acid sequence. Example of marker amino acid sequences comprise amino acid sequences that, upon exposure to a light, emit a detectable wavelength of light. One of ordinary skill in the art can measure the emission of light from the marker amino acid sequence by known techniques such as fluorescent microscopy, FRET or other, wavelength detection equipment.
Kits
In some embodiments, the present disclosure provides kits for cell administration and treatment of cancer in a subject in need thereof comprising at least one bacterial cell disclosed herein. In some embodiments, the kit comprises cell growth media. In some embodiments, the kit comprises cell growth media in a separate vessel from the at least one bacterial cell. In some embodiments, the kit further comprises cells of the cell type of interest. In some embodiments, the kits provide
Methods
The present invention relates to methods of treating and preventing cancer. In some embodiments, the methods comprise the step of administering the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the methods comprise the step of administering a therapeutically effective dose of at least one bacterial cell as a component of the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the methods comprise the step of administering a therapeutically effective dose of the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the methods comprise the step of administering a therapeutically effective dose of at least one bacterial cell as a component of the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent the growth or spread of metastatic cancer. In some embodiments, the invention relates to any of the disclosed methods comprising the step of administering a therapeutically effective dose of at least one bacterial cell as a component of the pharmaceutical compositions, compositions or food disclosed herein.
Embodiments include methods of using tumor-targeted bacteria to identify a therapeutically effective dose of therapeutic agent in a solid tumor, the method comprising administering any of the compositions, pharmaceutical compositions, or food products disclosed herein to a subject in need thereof. In some embodiments, the subject is suspected of having or has been diagnosed with cancer or metastatic cancer.
Embodiments also include methods of using tumor-targeted bacteria to deliver a timed therapeutically effective dose of therapeutic agent in regular intervals in a solid tumor, the method comprising administering any of the compositions, pharmaceutical compositions, or food products disclosed herein to a subject in need thereof. In some embodiments, the subject is suspected of having or has been diagnosed with cancer or metastatic cancer. In some embodiments, the methods herein comprise administering one or more stimuli that activate the promoter sequence or sequences and induce expression of one or more coding sequence on the one or more nucleic acid sequences residing in the at least one bacterial cell. Based upon the time administration of the one or more stimuli, bacteria that colonize cancer cells, solid tumors, or cells associated with hyperproliferative disorders may release, secrete, or express cellular toxins, therapeutic agents, or amino acids comprising one or more cell death domains.
The invention also relates to a method of predicting the quantitative expression or dosage of a therapeutic agent in a subject, the method comprising: administering any of the compositions, pharmaceutical compositions or food stuff disclosed herein.
A single plasmid, p-TD106-DD was generated by subcloning coding sequences into a synthesized DNA molecule by known molecular biology techniques. We transformed the DNA into bacteria to use for quorum sensing as means to deliver therapeutic payloads to a cancer cell. A restriction enzyme map of the plasmid is depicted in
The sequence of the plasmid (SEQ ID NO:1) follows:
Embodiments of the invention optionally include at least one bacterial cells comprising a plasmid optionally including one or more of the following sequences:
In some embodiments, the at least one bacterial cell comprises SEQ ID NO:7 or a nucleci acid sequence 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homolgous to SEQ ID NO:7.
The restriction map of SEQ ID NO:7 is depicted in FIG. IB.
Synthetic biology seeks to add controlled and dynamic production of cargo by utilizing computationally-designed “circuits” that have sophisticated sensing and delivery capability. These circuits can be designed to act as delivery systems that sense tumor-specific stimuli and self-regulate cargo production as accessary. Since plasmids are the common framework for synthetic circuits, we begin by characterizing the dynamics of plasmid-based gene expression in an in vivo mouse model by utilizing real-time luminescence imaging, quantitative biodistribution measurement, and computational modeling. Together, these approaches provide a framework for exploiting the inherent instability of plasmid-based networks, which will facilitate the generation of specific temporal release profiles directly within the tumor environment.
In the context of drug delivery, a critical parameter is the rate at which a device releases drug into the surrounding environment. For instance, materials have been investigated that generate “burst”, “delayed”, or “sustained” release characteristics. The transient plasmid-based system we have developed here can generate a similar variety of expression dynamics. For instance, Strain A produces an expression profile analogous to, burst release due to its fast growth rate and high rate of plasmid loss. In contrast, Strain B yields a sustained release profile owing to its slow growth rate and moderate rate of plasmid loss. Bacteria are unique in the context of drug-delivery vehicles in that they produce their own cargo, in contrast to other devices that are pre-loaded and depleted. This allows them to deliver a time-varying concentration of cargo in a designed profile directly on site. In the future, this work will enable a variety of drug-release profiles from engineered bacteria for therapeutic applications.
Developing both experimental and computational techniques in concert will be critical to engineering in vivo genetic circuits. Computational modeling can rapidly probe system parameters to explore potential outputs but must remain closely tied to experimental results to remain relevant. On the other hand, in vivo experiments present the most direct application of engineered circuits, but involve long timescales and the results often difficult to interpret. Here, we have utilized plasmid instability to generate transient expression profiles in tumor environments. In our computational model, we can predict how dosage, strain growth rate, and plasmid loss rate combine to yield differing expression dynamics. Then, these designs can be implemented experimentally by varying plasmid type, copy number, and maintenance system or by modifying the strain growth rate. Building on this platform, future applications will include engineered gene circuits that further extend the range of expression dynamics, sensing tumor-specific stimuli and self-regulating cargo production.
Materials and Methods
S. typhimurium strains Strain A (SL1344 PhoPQ−) and Strain B (SL1344 PhoPQ− aroA−) were provided by Elizabeth Hohmann (MGH) ([10]). The constitutive plasmid bearing luxCDABE genes was received as a gift ([12]). On the day of injection, bacteria containing plasmids were diluted 1/1000× into fresh LB media (Difco, 0.22 um filtered) with antibiotics (Ampicillin 100 ug/mL) and grown up to OD600=0.4-0.6. Cells were then prepared by washing 4 times with PBS (0.22 um filtered) and measured for OD600. Colony counts were performed on the preparation as a calibration and cells were prepared at various concentrations for 100 μL injections.
Subcutaneous human xenograft tumors were generated by injecting 5×106 OVCAR-8 cells (NCI DCTD Tumor Repository, Frederick, Md.) bilaterally into the hind flanks of 4-week old female Ncr/Nu mice. Cells were grown to 80-100% confluency in RPMI1640 media supplemented with 10% fetal bovine serum and antibiotics (100 I.U./mL penicillin and 100 μg/mL streptomycin) before injection. Cells were pelleted, resuspended in phenol, red-free DMEM with 15% reduced growth factor Matrigel (BD Biosciences). Tumors were allowed to grow for 10-20 days until tumor diameters of 200-400 mm were reached.
Colony counts were measured by dissecting tumors and organs from mice, homogenizing using a Tissue-Tearor (BioSpec), and plating serial dilutions on LB and LB Ampicillin plates. Prior to imaging, mice were anesthetized with 2-3% isoflurane. IVIS signals were measured using the IVIS Spectrum imaging system (Caliper Life Sciences) with 1-60 second exposure times, and Living Image software (Caliper Life Sciences) was used for analysis. Data where the tumor had ulcerated or had low signal (maximum of trajectory did not reach above 106 radiance, or approximately 5-10× initial background) were not included.
In
These circuits can be designed to act as delivery systems that sense tumor-specific stimuli and self-regulate cargo production as accessary. Since plasmids are the common framework for synthetic circuits, we begin by characterizing the dynamics of plasmid-based gene expression in an in vivo mouse model by utilizing real-time luminescence imaging, quantitative biodistribution measurement, and computational modeling. Together, these approaches provide a framework for exploiting the inherent instability of plasmid-based networks, which will facilitate the generation of specific temporal release profiles directly within the tumor environment.
We began by transforming two different attenuated strains of S. typhimurium with a constitutively expressed luciferase (luxCDABE) plasmid to allow for real-time monitoring of luminescence with an in vivo imaging system (IVIS). Strain A (ELH430:SL1344 phoPQ−) is attenuated for the PhoPQ regulon which is known to activate a number of genes related to virulence while Strain B (ELH1301:SL1344 phoPQ−aroA−) contains an additional aromatic amino acid synthesis mutation which effectively allows it to grow only in nutrient-rich environments. Importantly, while these strains are derived from the same parent (SL1344), their growth rates, and therefore plasmid-loss characteristics, differ significantly. To investigate the in vivo gene expression dynamics of these strains, we generated model xenograft tumors in mice by subcutaneous injection of a human ovarian cancer cell line (OVCAR-8). After measurable tumors were established, bacterial strains were injected intravenously via tail vein (
We then monitored tumor signal over the course of 60 hours using time-lapse IVIS imaging (
Characterization of Strain A and Strain B IVIS Profiles.
Each measurement was compared to counts taken in the spleen, a control tissue where there is a stable sub-population as the bacteria accumulate but do not grow or die. At each time point, organs were excised from the mouse and then homogenized and plated with or without antibiotic selection (
While the total population of bacteria grew throughout the course of the experiment (60 hours), the number of plasmid-containing bacteria reaches a maximum at 24 hours (
The tumor-spleen ratio is commonly reported as a characteristic measure of specificity and tumor-homing ability for a given strain. Bacteria accumulate in the spleen from the initial dosing yet do not subsequently grow and divide. Given that we observed essentially no increase in the bacterial count in the spleen throughout the duration of our experiments, the tumor-spleen ratio increased over time (
Modeling Bacterial Dynamics Inside of Tumor Environments
The tumor-spleen ratio is commonly reported as a characteristic measure of specificity and tumor-homing ability for a given strain. Bacteria accumulate in the spleen from the initial dosing yet do not subsequently grow and divide. Given that we observed essentially no increase in the bacterial count in the spleen throughout the duration of our experiments, the tumor-spleen ratio increased over time (
Developing a fully tunable dynamic expression platform will require a more complete understanding of the underlying processes. Plasmid-loss dynamics have been well described in a variety of in vitro and in vivo contexts; however, modeling of population or gene-expression dynamics has not yet been studied for in vivo tumor environments. Specifically, we hope to learn how expression dynamics are dictated by the rates of growth and plasmid-loss for a given strain. To accomplish this, we developed an ordinary differential equation (ODE) model describing internal plasmid and non-plasmid-containing bacteria and their respective expression of luciferase signal (
Our ODE model produced dynamics that were consistent with our experimental observations, where IVIS signal is taken to be proportional to the plasmid-containing population (
These effects correlate with experimental observations that can be explained based on differences in strain growth rate. Since plasmids are lost during cell division, the faster a cell replicates, the more frequently it loses plasmid. Thus, the faster growing Strain A accumulates luciferase quickly but loses a comparatively larger fraction of plasmids per day, resulting in higher IVIS values that peak at earlier time points than Strain B (
In the context of drug delivery, a critical parameter is the rate at which a device releases drug into the surrounding environment. For instance, materials have been investigated that generate “burst”, “delayed”, or “sustained” release characteristics. The transient plasmid-based system we have developed here can generate a similar variety of expression dynamics. For instance, Strain A produces an expression profile analogous to burst release due to its fast growth rate and high rate of plasmid loss. In contrast, Strain B yields a sustained release profile owing to its slow growth rate and moderate rate of plasmid loss. Bacteria are unique in the context of drug-delivery vehicles in that they produce their own cargo, in contrast to other devices that are preloaded and depleted. This difference allows them to deliver a time-varying concentration of cargo in a designed profile directly on site. In the future, this work will enable a variety of drug-release profiles from engineered bacteria for therapeutic applications.
Developing both experimental and computational techniques in concert will be critical to engineering in vivo genetic circuits. Computational modeling can rapidly probe system parameters to explore potential outputs but must remain closely tied to experimental results to remain relevant. On the other hand, in vivo experiments present the most direct application of engineered circuits, but involve long time scales and the results are often difficult to interpret. Here, we have utilized plasmid instability to generate transient expression profiles in tumor environments. In our computational model, we can predict how dosage, strain growth rate, and plasmid loss rate combine to yield differing expression dynamics. Subsequently, these designs can be implemented experimentally by varying plasmid type, copy number, and maintenance system or by modifying the strain growth rate. Building on this platform, future applications will include engineered gene circuits that further extend the range of expression dynamics, sensing tumor-specific stimuli and self-regulating cargo production.
Computational models are further explained by way of functions that can be used to determine rate of plasmid loss in a function of concentration of substrate for bacterial growth. Our ordinary differential equation model is presented below in non-dimensional form. The model describes the dynamics of two populations of bacteria, those containing the luminescent plasmid (n+) and those who have lost the plasmid (n−). The two populations grow inside the tumor environment and consume a substrate (S) which is in limited supply.
The parameters above are x, the rate at which cells lose plasmid, μ+max and μ−max, the maximal growth of plasmid and non-plasmid containing cells respectively. K, the Michaelis-saturation constant of growth rate, A+ and A−, the depletion rate constants of substrate S by μ+ and μ−cells. γ+ and γ−, the death rates of the bacteria, and q, the rate at which tumor substrate depletion is limited by the maximal amount of cells. This last term is to account for the fact that a limited number of bacteria (those on the outward growing rim) can contribute to the decay of the tumor substrate. The model is non-dimensionalized by hours, 1 bacteria, and a substrate concentration of μM.
The total in vivo system (IVIS) signal is reflective of the number of luciferase enzymes and hence the number of actively expressing luciferase bacteria. As an approximation to this signal, we modeled the signal to be proportional to the number of plasmid containing cells (dominant contribution to the IVIS signal) minus the first-order decay of the luciferase enzyme. We assume that each bacterium containing a plasmid contributes equally to the IVIS signal although there is likely variability due to the distribution of plasmids per cell in a population as well as contributions from non-plasmid containing bacteria where luciferase is not yet significantly diluted. Another approximation in the IVIS signal arises in that plasmid-containing bacteria initially populate the tumor core and express luciferase, but as bacteria grow radially to a larger population, less nutrients are left for the bacteria in the center to express any of the luxCDABE genes (either luciferase or luciferin substrates), which are the main contributors to the IVIS signal. This results in colony counts reaching a nearly steady-state as a function of time but expression level plateauing, causing an decay in IVIS signal due luciferase instability. The rate of change of the luciferase enzymes is given by:
where B represents the number of rate of expression of luciferase per cell and gL represents the luciferase decay. The IVIS signal (I) is proportional to the luciferase signal, i.e., I=xL, which scales parameters B and γL accordingly. The value of k contains physical properties 1 such as the permitivity of skin to luciferase enzymes and number of photons emitted per enzyme. The lumped parameters chosen for the data presented in
Dose limiting toxicity of bacterial therapies is considered to be an important factor which limits the ability of bacteria to colonize tumors. Here we constructed a plasmid which expresses iRGD, a peptide known to internalize or internalize conjugated nanoparticles into tumors. We genetically expressed iRGD as a fusion to a receptor of an outer-membrane protein known as eCPX at both the N and C terminus. The expression of eCPX-iRGD depicted in Figure IB is controlled by induction with arabinose, which allows us to tune the level of iRGD expressed on the surface of the bacterial cells.
Quorum Sensing bacteria injected intravenously into nude mice bearing OVCAR-8 xenograft hind flank tumors at a concentration of 1×106 bacteria comprising the pTD106CDD plasmid construct (
Programming drug expression and release can lead to more efficacious and safe therapies from live bacteria or other vectors. Here we employed a quorum sensing approach as an example of how programming bacteria can make improvements over current methods. Quorum sensing (QS) is a system bacteria use to trigger behavior when a colony reaches a certain level. We programmed our bacteria to produce a therapeutic called CDD, Cell Death Domain, which is a previously known peptide that causes cell death by apoptosis, upon reaching a quorum. CDD is a toxic peptide that would not be possible to administer systemically, thus a programmed delivery vehicle would be necessary to get it to the tumor. Our QS system ensures that many bacteria have to be present to produce CDD, and since bacterial therapies can have bacteria lodged in other organs, this allows for only the high concentration of bacteria seen in the tumor to produce CDD locally in the tumor, reducing systemic side effects. In addition, QS produces drugs with a different dynamical program, which is more in a burst fashion, while previous methods only used a constitutive always-ON method of production. This can potentially have implications in generating less drug resistance, since longer, constant exposures to a drug often lead to tumor drug resistance.
Salmonella bongori
Salmonella enterica subsp. enterica serovar 1,4,(5),12:i:-
Salmonella bongori N268-08
Salmonella enterica subsp. enterica serovar 3,10:e,h:-
Salmonella bongori NCTC 12419
Salmonella enterica subsp. enterica serovar 3,10:l,v:e,n,x
Salmonella bongori serovar 40:z35:-
Salmonella enterica subsp. enterica serovar 4,12:-:-
Salmonella bongori serovar 40:z35:- str. 95-0123
Salmonella enterica subsp. enterica serovar 4,1 2:a:-
Salmonella bongori serovar 48:i:-
Saimoneiia enterica subsp. enterica serovar 4,12:i:-
Salmonella bongori serovar 48:z35:-
Salmonella enterica subsp. enterica serovar 4,12:r:-
Salmonella bongori serovar 48:z41:—
Salmonella enterica subsp. enterica serovar 4,5,12:b:-
Salmonella bongori serovar 48:z41:— str. RKS3044
Salmonella enterica subsp. enterica serovar 4 [5],12:i:-
Salmonella bongori serovar 60:z41:-
Salmonella enterica subsp. enterica serovar 4,[5],12:r:-
Salmonella bongori serovar 66:z35:-
Salmonella enterica subsp. enterica serovar 4,[5]:b:-
Salmonella bongori serovar 66:z41:-
Salmonella enterica subsp. enterica serovar 6,7:-:-
Salmonella bongori serovar 66:z41:- str. SA19983605
Salmonella enterica subsp. enterica serovar 6,7:-:1,5
Salmonella enterica
Salmonella enterica subsp. enterica serovar 6,7:-:l,w
Salmonella enterica subsp. arizonae
Salmonella enterica subsp. enterica serovar 6,7:d:-
Salmonella enterica subsp. arizona serovar Untypable str. 73711
Salmonella enterica subsp. enterica serovar 6,7:k:-
Salmonella enterica subsp. arizonae serovar 17:z29:-
Salmonella enterica subsp. enterica serovar 6,7:l,v:-
Salmonella enterica subsp. arizonae serovar 18:z4,z23:-
Salmonella enterica subsp. enterica serovar 8,(20):-:z6
Salmonella enterica subsp. arizonae serovar 41:z4,z23:-
Salmonella enterica subsp. enterica serovar 8,(20):i:-
Salmonella enterica subsp. arizonae serovar 48:z4,z23:-
Salmonella enterica subsp. enterica serovar 9,12:-:-
Salmonella enterica subsp. arizonae serovar 53:-:-
Salmonella enterica subsp. enterica serovar 9,12:l,v:-
Salmonella enterica subsp. arizonae serovar 53:g,z51:-
Salmonella enterica subsp. enterica serovar Abaetetuba
Salmonella enterica subsp. arizonae serovar 56:z4,z23:-
Salmonella enterica subsp. enterica serovar Aberdeen
Salmonella enterica subsp. arizonae serovar 62:z36:-
Salmonella enterica subsp. enterica serovar Abony
Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
Salmonella enterica subsp. enterica serovar Abortus
Salmonella enterica subsp. arizonae str. SARC 5
Salmonella enterica subsp. enterica serovar Abortusequi
Salmonella enterica subsp. diarizonae
Salmonella enterica subsp. enterica serovar Abortusovis
Salmonella enterica subsp. diarizonae serovar ‘OMG’ l,v:l,5
Salmonella enterica subsp. enterica serovar Adelaide
Salmonella enterica subsp. diarizonae serovar 35:i:z35
Salmonella enterica subsp. enterica serovar Aesch
Salmonella enterica subsp. diarizonae serovar 38:z10:z53
Salmonella enterica subsp. enterica serovar Agama
Salmonella enterica subsp. diarizonae serovar 38[k]:z35:-
Salmonella enterica subsp. enterica serovar Agona
Salmonclla enterica subsp. diarizonae serovar 42:l,v:l,5,7
Salmonella enterica subsp. enterica serovar Alabama
Salmonella enterica subsp. diarizonae serovar 42:l,v:e,n,x,z15
Salmonella enterica subsp. enterica serovar Alachua
Salmonella enterica subsp. diarizonae serovar 47:k:z35
Salmonella enterica subsp. enterica serovar Albany
Salmonella enterica subsp. diarizonae serovar 47:l,v ‘HMG’
Salmonella enterica subsp. enterica serovar Altona
Salmonella enterica subsp. diarizonae serovar 47:l,v:l,5,(7)
Salmonella enterica subsp. enterica serovar Amsterdam
Salmonella enterica subsp. diarizonae serovar 48:i:z
Salmonella enterica subsp. enterica serovar Anatum
Salmonella enterica subsp. diarizonae serovar 48:k:z35
Salmonella enterica subsp. enterica serovar Ank
Salmonella enterica subsp. diarizonae serovar 50:l,2,3:k:z
Salmonella enterica subsp. enterica serovar Antsalova
Salmonella enterica subsp. diarizonae serovar 50:k:z
Salmonella enterica subsp. enterica serovar Apapa
Salmonella enterica subsp. diarizonae serovar 50:l,v:e,n,x,z15
Salmonella enterica subsp. enterica serovar Aqua
Salmonella enterica subsp. diarizonae serovar 50:r:l,5
Salmonella enterica subsp. enterica serovar Arechavaleta
Salmonella enterica subsp. diarizonae serovar 58:z52:z35
Salmonella enterica subsp. enterica serovar Arizona
Salmonella enterica subsp. diarizonae serovar 59:zl0:-
Salmonella enterica subsp. enterica serovar Augustenborg
Salmonella enterica subsp. diarizonae serovar 59:zl0:z53
Salmonella enterica subsp. enterica serovar Austin
Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,zl5
Salmonella enterica subsp. enterica serovar Azteca
Salmonella enterica subsp. diarizonae serovar 60:r:enxzl5
Salmonella enterica subsp. enterica serovar Baildon
Salmonella enterica subsp. diarizonae serovar 60:z52:l,5
Salmonella enterica subsp. enterica serovar Banana
Salmonella enterica subsp. diarizonae serovar 60:z55:e,n,x
Salmonella enterica subsp. enterica serovar Bangkok
Salmonella enterica subsp. diarizonae serovar 61:-:1,5,7
Salmonella enterica subsp. enterica serovar Bangui
Salmonella enterica subsp. diarizonae serovar 61:c:l,5,(7)
Salmonella enterica subsp. enterica serovar Bardo
Salmonella enterica subsp. diarizonae serovar 61:k:l,5,7
Salmonella enterica subsp. enterica serovar Bareilly
Salmonella enterica subsp. diarizonae serovar 61:k:l,5,77
Salmonella enterica subsp. enterica serovar Barranquilla
Salmonella enterica subsp. diarizonae serovar 65:c:l,5,7
Salmonella enterica subsp. enterica serovar Bergen
Salmonella enterica subsp. diarizonae serovar 65:c:z
Salmonella enterica subsp. enterica serovar Berta
Salmonella enterica subsp. diarizonae serovar 061:k:l,5
Salmonella enterica subsp. enterica serovar Binza
Salmonella enterica subsp. diarizonae str. 01-005
Salmonella enterica subsp. enterica serovar Bispebjerg
Salmonella enterica subsp. diarizonae str. 36806
Salmonella enterica subsp. enterica serovar Bissau
Salmonella enterica subsp. diarizonae str. ATCC BAA-1579
Salmonella enterica subsp. enterica serovar Blegdam
Salmonella enterica subsp. enterica str. 77231
Salmonella enterica subsp. enterica serovar Blockley
Salmonella enterica subsp. enterica
Salmonella enterica subsp. enterica serovar Bonaricnsis
Salmonella enterica subsp. enterica serovar ‘02-6026 18:1 v-z-
Salmonella enterica subsp. enterica serovar Bonn
Salmonella enterica subsp. enterica serovar Borreze
Saimoneila enterica subsp. enterica serovar Bovismorbificans
Salmonella enterica subsp. enterica serovar Hvittingfoss
Salmonella enterica subsp. enterica serovar Braenderup
Salmonella enterica subsp. enterica serovar Idikan
Salmonella enterica subsp. enterica serovar Brandenburg
Salmonella enterica subsp. enterica serovar India
Salmonella enterica subsp. enterica serovar Bredeney
Salmonella enterica subsp. enterica serovar Indiana
Salmonella enterica subsp. enterica serovar Bron
Salmonella enterica subsp. enterica serovar Infantis
Salmonella enterica subsp. enterica serovar Brunei
Salmonella enterica subsp. enterica serovar Inverness
Salmonella enterica subsp. enterica serovar Bsilla
Salmonella enterica subsp. enterica serovar Isangi
Salmonella enterica subsp. enterica serovar Budapest
Salmonella enterica subsp. enterica serovar Istanbul
Salmonella enterica subsp. enterica serovar Bury
Salmonella enterica subsp. enterica serovar Itami
Salmonella enterica subsp. enterica serovar California
Salmonella enterica subsp. enterica serovar Javiana
Salmonella enterica subsp. enterica serovar Canada
Salmonella enterica subsp. enterica serovar Jericho
Salmonella enterica subsp. enterica serovar Caracas
Salmonella enterica subsp. enterica serovar Johannesburg
Salmonella enterica subsp. enterica serovar Carrau
Salmonella enterica subsp. enterica serovar Kahla
Salmonella enterica subsp. enterica serovar Cerro
Salmonella enterica subsp. enterica serovar Kedougou
Salmonella enterica subsp. enterica serovar Champaign
Salmonella enterica subsp. enterica serovar Kentucky
Salmonella enterica subsp. enterica serovar Chester
Salmonella enterica subsp. enterica serovar Keurmassar
Salmonella enterica subsp. enterica serovar Chincol
Salmonella enterica subsp. enterica serovar Kiambu
Salmonella enterica subsp. enterica serovar Chingola
Salmonella enterica subsp. enterica serovar Kiel
Salmonella enterica subsp. enterica serovar Choleraesuis
Salmonella enterica subsp. enterica serovar Kinshasa
Salmonella enterica subsp. enterica serovar Coeln
Salmonella enterica subsp. enterica serovar Kintambo
Salmonella enterica subsp. enterica serovar Concord
Salmonella enterica subsp. enterica serovar Kisangani
Salmonella enterica subsp. enterica serovar Coogee
Salmonella enterica subsp. enterica serovar Kitenge
Salmonella enterica subsp. enterica serovar Copenhagen
Salmonella enterica subsp. enterica serovar Kocsscn
Salmonella enterica subsp. enterica serovar Corvallis
Salmonella enterica subsp. enterica serovar Kottbus
Salmonella enterica subsp. enterica serovar Crossness
Salmonella enterica subsp. enterica serovar Krefeld
Saimoneila enterica subsp. enterica serovar Cubana
Salmonella enterica subsp. enterica serovar Kundunchi
Salmonella enterica subsp. enterica serovar Dakar
Salmonella enterica subsp. enterica serovar Kunzendorf
Salmonella enterica subsp. enterica serovar Decatur
Salmonella enterica subsp. enterica serovar Lansing
Salmonella enterica subsp. enterica serovar Derby
Salmonella enterica subsp. enterica serovar Lexington
Salmonella enterica subsp. enterica serovar Djakarta
Salmonella enterica subsp. enterica serovar Lille
Salmonella enterica subsp. enterica serovar Doorn
Salmonella enterica subsp. enterica serovar Limete
Salmonella enterica subsp. enterica serovar Dowd
Salmonella enterica subsp. enterica serovar Lindenburg
Salmonella enterica subsp. enterica serovar Dublin
Salmonella enterica subsp. enterica serovar Litchfield
Salmonella enterica subsp. enterica serovar Duesseldorf
Salmonella enterica subsp. enterica serovar Liverpool
Salmonella enterica subsp. enterica serovar Duisburg
Salmonella enterica subsp. enterica serovar Livingstone
Salmonella enterica subsp. enterica serovar Durban
Salmonella enterica subsp. enterica serovar Lomita
Salmonella enterica subsp. enterica serovar Eastbourne
Salmonella enterica subsp. enterica serovar London
Salmonella enterica subsp. enterica serovar Edinburgh
Salmonella enterica subsp. enterica serovar Macclesfield
Salmonella enterica subsp. enterica serovar Emek
Salmonella enterica subsp. enterica serovar Madelia
Salmonella enterica subsp. enterica serovar Enteritidis
Salmonella enterica subsp. enterica serovar Madjorio
Salmonella enterica subsp. enterica serovar Epinay
Salmonella enterica subsp. enterica serovar Manchester
Salmonella enterica subsp. enterica serovar Eschberg
Salmonella enterica subsp. enterica serovar Manhattan
Salmonella enterica subsp. enterica serovar Essen
Salmonella enterica subsp. enterica serovar Maracaibo
Salmonella enterica subsp. enterica serovar Etterbeek
Salmonella enterica subsp. enterica serovar Maregrosso
Salmonella enterica subsp. enterica serovar Farsta
Salmonella enterica subsp. enterica serovar Marrtens
Salmonella enterica subsp. enterica serovar Fischerhuette
Salmonella enterica subsp. enterica serovar Matopeni
Salmonella enterica subsp. enterica serovar Fischerkietz
Salmonella enterica subsp. enterica serovar Mbandaka
Salmonella enterica subsp. enterica serovar Flottbek
Salmonella enterica subsp. enterica serovar Mcleagridis
Salmonella enterica subsp. enterica serovar Freetown
Salmonella enterica subsp. enterica serovar Mgulani
Salmonella enterica subsp. enterica serovar Fresno
Salmonella enterica subsp. enterica serovar Miami
Salmonella enterica subsp. enterica serovar Fulica
Salmonella enterica subsp. enterica serovar Michigan
Salmonella enterica subsp. enterica serovar Gallinarum
Salmonella enterica subsp. enterica serovar Mikawasima
Salmonella enterica subsp. enterica serovar Gallinarum/pullorum
Salmonella enterica subsp. enterica serovar Milwaukee
Salmonella enterica subsp. enterica serovar Gamaba
Salmonella enterica subsp. enterica serovar Minneapolis
Salmonella enterica subsp. enterica serovar Gaminara
Salmonella enterica subsp. enterica serovar Minnesota
Salmonella enterica subsp. enterica serovar Garoli
Salmonella enterica subsp. enterica serovar Mississippi
Salmonella enterica subsp. enterica serovar Gatuni
Salmonella enterica subsp. enterica serovar Molade
Salmonella enterica subsp. enterica serovar Give
Salmonella enterica subsp. enterica serovar Monophasic
Saimoneila enterica subsp. enterica serovar Glostrup
Salmonella enterica subsp. enterica serovar Monschaui
Salmonella enterica subsp. enterica serovar Goettingen
Salmonella enterica subsp. enterica serovar Montevideo
Salmonella enterica subsp. enterica serovar Goldcoast
Salmonella enterica subsp. enterica serovar Moscow
Salmonella enterica subsp. enterica serovar Grumpensis
Salmonella enterica subsp. enterica serovar Muenchen
Salmonella enterica subsp. enterica serovar Gueuletapee
Salmonella enterica subsp. enterica serovar Muenster
Salmonella enterica subsp. enterica serovar Hadar
Salmonella enterica subsp. enterica serovar Mygdal
Salmonella enterica subsp. enterica serovar Haifa
Salmonella enterica subsp. enterica serovar Naestved
Salmonella enterica subsp. enterica serovar Hartford
Salmonella enterica subsp. enterica serovar Napoli
Salmonella enterica subsp. enterica serovar Havana
Salmonella enterica subsp. enterica serovar Nchanga
Salmonella enterica subsp. enterica serovar Heidelberg
Salmonella enterica subsp. enterica serovar Neukoelln
Salmonella enterica subsp. enterica serovar Ilessarek
Salmonella enterica subsp. enterica serovar Newbrunswick
Salmonella enterica subsp. enterica serovar Hillingdon
Salmonella enterica subsp. enterica serovar Newington
Saimoneila enterica subsp. enterica serovar Newlands
Salmonella enterica subsp. enterica serovar Tennessee
Salmonella enterica subsp. enterica serovar Newmexico
Salmonella enterica subsp. enterica serovar Tennyson
Salmonella enterica subsp. enterica serovar Newport
Salmonella enterica subsp. enterica serovar Texas
Salmonella enterica subsp. enterica serovar Ngili
Salmonella enterica subsp. enterica serovar Thompson
Salmonella enterica subsp. enterica serovar Niarembe
Salmonella enterica subsp. enterica serovar Tinda
Salmonella enterica subsp. enterica serovar Nima
Salmonella enterica subsp. enterica serovar Togba
Salmonella enterica subsp. enterica serovar Nitra
Salmonella enterica subsp. enterica serovar Tonev
Salmonella enterica subsp. enterica serovar Norwich
Salmonella enterica subsp. enterica serovar Toronto
Salmonella enterica subsp. enterica serovar Nottingham
Salmonella enterica subsp. enterica serovar Toulon
Salmonella enterica subsp. enterica serovar O rough
Salmonella enterica subsp. enterica serovar Travis
Salmonella enterica subsp. enterica serovar O rough O:r:l,2
Salmonella enterica subsp. enterica serovar Tripoli
Salmonella enterica subsp. enterica serovar 07:Hc:l,5
Salmonella enterica subsp. enterica serovar Tshiongwe
Salmonella enterica subsp. enterica serovar 07:Hh:l,5
Salmonella enterica subsp. enterica serovar Tucson
Salmonella enterica subsp. enterica serovar Ohio
Salmonella enterica subsp. enterica serovar Typhi
Salmonella enterica subsp. Enterica serovar Ondcrstcpoort
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Oranienburg
Salmonella enterica subsp. enterica serovar Typhisuis
Salmonella enterica subsp. enterica serovar Ordonez
Salmonella enterica subsp. enterica serovar Uganda
Salmonella enterica subsp. enterica serovar Orion
Salmonella enterica subsp. enterica serovar Untypable str. 75788
Salmonella enterica subsp. enterica serovar Oslo
Salmonella enterica subsp. enterica serovar Untypable str. 77116
Salmonella enterica subsp. enterica serovar Osnabrueck
Salmonella enterica subsp. enterica serovar Untypable str. 77132
Salmonella enterica subsp. enterica serovar Othmarschen
Salmonella enterica subsp. enterica serovar Untypable str. 77528
Salmonella enterica subsp. enterica serovar Ouakam
Salmonella enterica subsp. enterica serovar Untypable str. 81146
Salmonella enterica subsp. enterica serovar Ovcrvccht
Salmonella enterica subsp. enterica serovar Untypable str. 83332
Salmonella enterica subsp. enterica serovar Panama
Salmonella enterica subsp. enterica serovar Untypable str. 83987
Salmonella enterica subsp. enterica serovar Paratyphi A
Salmonella enterica subsp. enterica serovar Untypable str. 91013
Saimoneila enterica subsp. enterica serovar Paratyphi B
Salmonella enterica subsp. enterica serovar Untypable str. 91510
Salmonella enterica subsp. enterica serovar Paratyphi C
Salmonella enterica subsp. enterica serovar Untypable str. 92055
Salmonella enterica subsp. enterica serovar Pensacola
Salmonella enterica subsp. enterica serovar Uphill
Salmonella enterica subsp. enterica serovar Poano
Salmonella enterica subsp. enterica serovar Urbana
Salmonella enterica subsp. enterica serovar Poeseldorf
Salmonella enterica subsp. enterica serovar Utrecht
Salmonella enterica subsp. enterica serovar Pomona
Salmonella enterica subsp. enterica serovar Vellore
Salmonella enterica subsp. enterica serovar Poona
Salmonella enterica subsp. enterica serovar Virchow
Salmonella enterica subsp. enterica serovar Portedeslilas
Salmonella enterica subsp. enterica serovar Virginia
Salmonella enterica subsp. enterica serovar Potsdam
Salmonella enterica subsp. enterica serovar Wagenia
Salmonella enterica subsp. enterica serovar Pullorum
Salmonella enterica subsp. enterica serovar Wandsworth
Salmonella enterica subsp. enterica serovar Putten
Salmonella enterica subsp. enterica serovar Wangata
Salmonella enterica subsp. enterica serovar Quebec
Salmonella enterica subsp. enterica serovar Washington
Salmonella enterica subsp. enterica serovar Rachaburi
Salmonella enterica subsp. enterica serovar Waycross
Salmonella enterica subsp. enterica serovar Reading
Salmonella enterica subsp. enterica serovar Weltevreden
Salmonella enterica subsp. enterica serovar Richmond
Salmonella enterica subsp. enterica serovar Weslaco
Salmonella enterica subsp. enterica serovar Rissen
Salmonella enterica subsp. enterica serovar Westhampton
Salmonella enterica subsp. enterica serovar Rosenberg
Salmonella enterica subsp. enterica serovar Wien
Salmonella enterica subsp. enterica serovar Rostock
Salmonella enterica subsp. enterica serovar Worthington
Salmonella enterica subsp. enterica serovar Rubislaw
Salmonella enterica subsp. enterica serovar York
Salmonella enterica subsp. enterica serovar Saintpaul
Salmonella enterica subsp. enterica serovar Yovokome
Salmonella enterica subsp. enterica serovar Salford
Salmonella enterica subsp. enterica serovar Zaiman
Salmonella enterica subsp. enterica serovar Sandiego
Salmonella enterica subsp. enterica serovar Zanzibar
Salmonella enterica subsp. enterica serovar Sangcra
Salmonella enterica subsp. enterica str. 01-11525
Salmonella enterica subsp. enterica serovar Sanjuan
Salmonella enterica subsp. enterica str. 09-06166
Salmonella enterica subsp. enterica serovar Sanktgeorg
Salmonella enterica subsp. enterica str. 11-01213
Salmonella enterica subsp. enterica serovar Sarajane
Salmonella enterica subsp. enterica str. 11-01214
Salmonella enterica subsp. enterica serovar Schlcisshcim
Salmonella enterica subsp. enterica str. 11-01216-1
Salmonella enterica subsp. enterica serovar Schwarzengrund
Salmonella enterica subsp. enterica str. 609458-2604314 2-2
Salmonella enterica subsp. enterica serovar Sendai
Salmonella enterica subsp. enterica str. 85356
Salmonella enterica subsp. enterica serovar Senftenberg
Salmonella enterica subsp. enterica str. CFSAN004167
Salmonella enterica subsp. enterica serovar Setubal
Salmonella enterica subsp. enterica str. S703
Salmonella enterica subsp. enterica serovar Shomron
Salmonella enterica subsp. enterica str. xld
Salmonella enterica subsp. enterica serovar Simsbury
Salmonella enterica subsp. houtenae
Saimoneila enterica subsp. enterica serovar Singapore
Salmonella enterica subsp. houtenae serovar l,40:g,z51:-
Salmonella enterica subsp. enterica serovar Sloterdijk
Salmonella enterica subsp. houtenae serovar I,40:z4,z24:-
Salmonella enterica subsp. enterica serovar Soalianina
Salmonella enterica subsp. houtenae serovar 16:z4,z32:-
Salmonella enterica subsp. enterica serovar Soerenga
Salmonella enterica subsp. houtenae serovar 16:z4,z32:--
Salmonella enterica subsp. enterica serovar Stanley
Salmonella enterica subsp. houtenae serovar 40:z4,z24:-
Salmonella enterica subsp. enterica serovar Stanleyville
Salmonella enterica subsp. houtenae serovar 43:z4,z23:-
Salmonella enterica subsp. enterica serovar Stellingen
Salmonella enterica subsp. houtenae serovar 44:a:-
Salmonella enterica subsp. enterica serovar Stourbridge
Salmonella enterica subsp. houtenae serovar 44:z4,z23:-
Salmonella enterica subsp. enterica serovar Taksony
Salmonella enterica subsp. houtenae serovar 45a,b:g,z51:-
Salmonella enterica subsp. enterica serovar Tallahassee
Salmonella enterica subsp. houtenae serovar 48:g,z51:-
Salmonella enterica subsp. enterica serovar Tejas
Salmonella enterica subsp. houtenae serovar 50:g,z51:-
Salmonella enterica subsp. enterica serovar Telaviv
Salmonella enterica subsp. houtenae serovar 6,7:z4,z24:-
Saimoneila enterica subsp. houtenae serovar Houten
Salmonella sp. APK1
Salmonella enterica subsp. houtenae str. ATCC BAA-1580
Salmonella sp. ATK1
Salmonella enterica subsp. houtenae str. ATCC BAA-1581
Salmonella sp. AV(2010)
Salmonella enterica subsp. indica
Salmonella sp. BSCC 29
Salmonella enterica subsp. indica serovar l,6,14,25:a:e,n,x
Salmonella sp. BV10
Salmonella enterica subsp. indica serovar ll:b:l,7
Salmonella sp. BV34
Salmonella enterica subsp. indica serovar ll:b:e,n,x
Salmonella sp. BV37
Salmonella enterica subsp. indica serovar 45:a:e,n,x
Salmonella sp. Bz21
Salmonella enterica subsp. indica serovar 6,14,25:zl0:l,(2),7
Salmonella sp. CASMBAUKKAGK2
Salmonella enterica subsp. indica serovar 6,7:z41:l,7
Salmonella sp. CDC 156-87
Salmonella enterica subsp. indica str. ATCC BAA-1576
Salmonella sp. CMCC50041
Salmonella enterica subsp. indica str. ATCC BAA-1578
Salmonella sp. Co9901
Salmonella enterica subsp. salamae
Salmonella sp. Co9936
Salmonella enterica subsp. salamae serovar l,4,12,27:a:e,n,x
Salmonella sp. Co9937
Salmonella enterica subsp. salamae serovar l,4,12,27:b:c,n,x
Salmonella sp. CRMB13
Salmonella enterica subsp. salamae serovar l,40:zl0:e,n,x
Salmonella sp. CRMB68
Salmonella enterica subsp. salamae serovar l,9,12:d:e,n,x
Salmonella sp. CRTB1
Salmonella enterica subsp. salamae serovar 1,9,12:l,w:e,n,x
Salmonella sp. CRTB29
Salmonella enterica subsp. salamae serovar 1 l:l,z28:e,n,x
Salmonella sp. CRTB7
Salmonella enterica subsp. salamae serovar 35:g,z62:e,n,x
Salmonella sp. D187-2
Salmonella enterica subsp. salamae serovar 35:m,t:e,n,x
Salmonella sp. D194-1
Salmonella enterica subsp. salamae serovar 4,12,27:i:z35
Salmonella sp. D194-2
Salmonella enterica subsp. salamae serovar 4,12:z:l,7
Salmonella sp. D76
Salmonella enterica subsp. salamae serovar 40:zl0:e,n,x
Salmonella sp. DAPS
Salmonella enterica subsp. salamae serovar 42:f,g,t:--
Salmonella sp. DSPV 002PSA
Saimoneila enterica subsp. salamae serovar 42:l,v:e,n,x,zl5
Salmonella sp. ES-B43
Salmonella enterica subsp. salamae serovar 48:d:z6
Salmonella sp. H16-244
Salmonella enterica subsp. salamae serovar 55:k:z39
Salmonella sp. H17-62
Salmonella enterica subsp. salamae serovar 56:zl:enx
Salmonella sp. H3
Salmonella enterica subsp. salamae serovar 57:z42:l,6:z53
Salmonella sp. H48
Salmonella enterica subsp. salamae serovar 58:l,zl3,z28:z6
Salmonella sp. ICMP 15669
Salmonella enterica subsp. salamae serovar 6,7:l,w:l,5,7
Salmonella sp. Inspire71
Salmonella enterica subsp. salamae serovar 9,12:d:e,n,x
Salmonella sp. Inspire72
Salmonella enterica subsp. salamae serovar 9,12:l,v:e,n,x
Salmonella sp. Inspire73
Salmonella enterica subsp. salamae serovar Greenside
Salmonella sp. Inspire74
Salmonella enterica subsp. salamae serovar Sofia
Salmonella sp. Inspire75
Salmonella enterica subsp. salamae str. 3588/07
Salmonella sp. JPunkl-2
Salmonella enterica subsp. salamae str. ATCC BAA-15 82
Salmonella sp. LCN1-13
Salmonella enterica subsp. salamae str. ATCC BAA-15 83
Salmonella sp. LFW070403
Salmonella enterica subsp. salamae str. DMA-1
Salmonella sp. Lorraine road_2007_01
Salmonella enterica subsp. VII
Salmonella sp. Lorraine road_2007_03
Salmonella enterica VII l,40:g,z51:--
Salmonella sp. Lorraine road_2007_07
Salmonella enterica VII 40:z4,z24:--
Salmonella sp. Lorraine road_2007_08
Salmonella subterranea
Salmonella sp. Lorraine road_2007_14
Salmonella sp.
Salmonella sp. Lorraine road_2007_16
Salmonella sp. ‘group B’
Salmonella sp. Lorraine road_2007_17
Salmonella sp. 10
Salmonella sp. Lorraine road_2007_19
Salmonella sp. 14
Salmonella sp. M9
Salmonella sp. 2
Salmonella sp. M9397
Salmonella sp. 30
Salmonella sp. MRT3
Salmonella sp. 40
Salmonella sp. Pratt ave_2007_03
Salmonella sp. 4063
Salmonella sp. Pratt ave_2007_06
Salmonella sp. 4064
Salmonella sp. Pratt ave_2007_10
Salmonella sp. 4065
Salmonella sp. Pratt ave_2007_11
Salmonella sp. 4066
Salmonella sp. Pratt ave_2007_12
Salmonella sp. 4071
Salmonella sp. Pratt ave_2007_14
Salmonella sp. 4072
Salmonella sp. Pratt ave_2007_15
Salmonella sp. 4182
Salmonella sp. Pratt ave_2007_16
Saimoneila sp. 45
Salmonella sp. RG-14/07
Salmonella sp. 467
Salmonella sp. RPWA1.6
Salmonella sp. 53
Salmonella sp. RV_A06_3c
Salmonella sp. 56
Salmonella sp. s010
Salmonella sp. 577
Salmonella sp. s084
Salmonella sp. 6R
Salmonella sp. S126
Salmonella sp. 77
Salmonella sp. S138
Salmonella sp. 85 MP
Salmonella sp. S14
Salmonella sp. 8R
Salmonella sp. S191
Salmonella sp. 9
Salmonella sp. S1a
Salmonella sp. 96A-29192
Salmonella sp. SAM2
Salmonella sp. AHL 6
Salmonella sp. sc-S
Salmonella sp. SSBC3
Salmonella sp. Trautman ave_2007_26
Salmonella sp. STM13
Salmonella sp. Trautman ave_2007_27
Salmonella sp. Tla
Salmonella sp. Trautman ave_2007_28
Salmonella sp. TC67
Salmonella sp. Trautman ave_2007_29
Salmonella sp. TR-95
Salmonella sp. Vetaran hospital_2007_03
Salmonella sp. Trautman ave_2007_01
Salmonella sp. Vetaran hospital_2007_20
Salmonella sp. Trautman ave_2007_02
Salmonella sp. Veteran hospital_2007_01
Salmonella sp. Trautman ave_2007_03
Salmonella sp. Veteran hospital_2007_02
Salmonella sp. Trautman ave_2007_04
Salmonella sp. Veteran hospital_2007_07
Salmonella sp. Trautman ave_2007_05
Salmonella sp. Veteran hospital_2007_08
Salmonella sp. Trautman ave_2007_06
Salmonella sp. Veteran hospital_2007_11
Salmonella sp. Trautman ave_2007_07
Salmonella sp. Veteran hospital_2007_14
Salmonella sp. Trautman ave_2007_08
Salmonella sp. VI11
Salmonella sp. Trautman ave_2007_09
Salmonella sp. VII
Salmonella sp. Trautman ave_2007_10
Salmonella sp. WT
Salmonella sp. Trautman ave_2007_11
Salmonella sp. XJ-ZG1
Salmonella sp. Trautman ave_2007_12
Salmonella sp. YLA4
Salmonella sp. Trautman ave_2007_13
Salmonella sp. YLD3
Salmonella sp. Trautman ave_2007_14
Salmonella sp. ZKC20
Salmonella sp. Trautman ave_2007_15
Salmonella sp. ZZ-4
Salmonella sp. Trautman ave_2007_16
Salmonella sp. Trautman ave_2007_17
Salmonella sp. enrichment culture clone CL107
Salmonella sp. Trautman ave_2007_18
Salmonella sp. enrichment culture clone NEP50
Salmonella sp. Trautman ave_2007_19
Salmonella sp. enrichment culture clone NJ-8
Salmonella sp. Trautman ave_2007_20
Salmonella sp. enrichment culture clone TB43_1
Salmonella sp. Trautman ave_2007_21
Salmonella sp. enrichment culture clone TB43_2
Salmonella sp. Trautman ave_2007_22
Salmonella sp. enrichment culture clone TB43_3
Salmonella sp. Trautman ave_2007_23
Salmonella sp. enrichment culture clone TB43_4
Salmonella sp. Trautman ave_2007_24
Salmonella sp. Trautman ave_2007_25
Escherichia albertii
Escherichia coli 10.0833
Escherichia albertii B090
Escherichia coli 10.0869
Escherichia albertii B1 56
Escherichia coli 13B01
Escherichia albertii NBRC 107761
Escherichia coli 1412
Escherichia albertii TW07627
Escherichia coli 14A
Escherichia albertii TW08933
Escherichia coli 19B05
Escherichia albertii TW11588
Escherichia coli 113290
Escherichia albertii TW15818
Escherichia coli 113302
Escherichia coli
Escherichia coli 113303
Escherichia coli O.1288
Escherichia coli 1303
Escherichia coli #1/H766
Escherichia coli 2.3941
Escherichia coli ‘BL21-Gold(DE3)pLysS AG’
Escherichia coli 2.4168
Escherichia coli O8BKT055439
Escherichia coli 2.41 74
Escherichia coli O8BKT77219
Escherichia coli 201600.1
Escherichia coli O.1197
Escherichia coli 20B05
Escherichia coli O7798
Escherichia coli 2254-75 (11a)
Escherichia coli 101-1
Escherichia coli 229_11
Escherichia coli 110957
Escherichia coli 2362-75
Escherichia coli O9BKT078844
Escherichia coli 23B03
Escherichia coli 1.0080
Escherichia coli 24B05
Escherichia coli 1.2264
Escherichia coli 2534-86
Escherichia coli 1.2741
Escherichia coli 2719100
Escherichia coli O9BKT024447
Escherichia coli 2720900
Escherichia coli O9BKT076207
Escherichia coli 179100
Escherichia coli O.1304
Escherichia coli 179550
Escherichia coli 151_06
Escherichia coli 180050
Escherichia coli 1520
Escherichia coli 180200
Escherichia coli 174750
Escherichia coli 180600
Escherichia coli 174900
Escherichia coli 1827-70
Escherichia coli 178200
Escherichia coli 199900.1
Escherichia coli 178850
Escherichia coli 2733950
Escherichia coli 178900
Escherichia coli 2735000
Escherichia coli 112469215-isolatel
Escherichia coli 2741950
Escherichia coli 112469218-isolatel
Escherichia coli 2747800
Escherichia coli 10.0562
Escherichia coli 2749250
Escherichia coli 10.0821
Escherichia coli 2756500
Escherichia coli 2762100
Escherichia coli 2860650
Escherichia coli 2770900
Escherichia coli 2861200
Escherichia coli 2780750
Escherichia coli 55989
Escherichia coli 2785200
Escherichia coli 576-1
Escherichia coli 2788150
Escherichia coli 5905
Escherichia coli 2845350
Escherichia coli 6.0172
Escherichia coli 2845650
Escherichia coli 6.168
Escherichia coli 2846750
Escherichia coli 7.1485
Escherichia coli 2846750-DM-A
Escherichia coli 7.1495
Escherichia coli 2846750-DM-B
Escherichia coli 7.1575
Escherichia coli 2846750-DM-B-A
Escherichia coli 7.3192
Escherichia coli 2846750-DM-B-B
Escherichia coli 75
Escherichia coli 2848050
Escherichia coli 754_10
Escherichia coli 2850400
Escherichia coli 79
Escherichia coli 2850750
Escherichia coli 8.0416
Escherichia coli 2851500
Escherichia coli 8.0566
Escherichia coli 2853500
Escherichia coli 8.0569
Escherichia coli 1E14
Escherichia coli 8.0586
Escherichia coli 2.073 1
Escherichia coli 8.2256
Escherichia coli 2.0966
Escherichia coli 8.2524
Escherichia coli 2.3916
Escherichia coli 83972
Escherichia coli 2862600
Escherichia coli 85.0143
Escherichia coli 2864350
Escherichia coli 85.1284
Escherichia coli 2865200
Escherichia coli 8624
Escherichia coli 2866350
Escherichia coli 87-1713(10i)
Escherichia coli 2722950
Escherichia coli 88.0221
Escherichia coli 2726800
Escherichia coli 88.1042
Escherichia coli 2726950
Escherichia coli 88.1467
Escherichia coli 2729250
Escherichia coli 88817 (10j)
Escherichia coli 2729250-DM-A
Escherichia coli 89.0511
Escherichia coli 2729250-DM-B
Escherichia coli 9.0111
Escherichia coli 2729250-DM-B-A
Escherichia coli 9.1649
Escherichia coli 2729250-DM-B-B
Escherichia coli 2866450
Escherichia coli 2730350
Escherichia coli 908616
Escherichia coli 2730450
Escherichia coli 908624
Escherichia coli 2731150
Escherichia coli 908632
Escherichia coli 2866550
Escherichia coli 908658
Escherichia coli 2866750
Escherichia coli 908675
Escherichia coli 2867750
Escherichia coli 908691
Escherichia coli 2871950
Escherichia coli 909945-2
Escherichia coli 2872000
Escherichia coli 53638
Escherichia coli 2872800
Escherichia coli 541-1
Escherichia coli 2875000
Escherichia coli 541-15
Escherichia coli 2875150
Escherichia coli 5412
Escherichia coli 2886-75
Escherichia coli 93-001
Escherichia coli 290 10
Escherichia coli 93-111
Escherichia coli 3.0190
Escherichia coli 93.0055
Escherichia coli 3.2303
Escherichia coli 93.0056
Escherichia coli 3.2608
Escherichia coli 93.0624
Escherichia coli 3.3884
Escherichia coli 94.0618
Escherichia coli 3.4870
Escherichia coli 95.0183
Escherichia coli 3.4871
Escherichia coli 95.0941
Escherichia coli 3003
Escherichia coli 95.0943
Escherichia coli 3006
Escherichia coli 95.1288
Escherichia coli 3030-1
Escherichia coli 95JB1
Escherichia coli 3350-73 (13a)
Escherichia coli 95NR1
Escherichia coli 3431
Escherichia coli 96.0107
Escherichia coli 371 08
Escherichia coli 96.0109
Escherichia coli 4.0522
Escherichia coli 96.0427
Escherichia coli 4.0967
Escherichia coli 96.0428
Escherichia coli 4_1_47FAA
Escherichia coli 96.0497
Escherichia coli 5.0588
Escherichia coli 96.0932
Escherichia coli 5.0959
Escherichia coli 96.0939
Escherichia coli 5.2219
Escherichia coli 96.154
Escherichia coli 5.2239
Escherichia coli 97.0003
Escherichia coli 5.2246
Escherichia coli 97.0007
Escherichia coli 5.3169
Escherichia coli 97.0010
Escherichia coli 536
Escherichia coli 97.0246
Escherichia coli 2854350
Escherichia coli 97.0259
Escherichia coli 2860050
Escherichia coli 97.0264
Escherichia coli 97.1742
Escherichia coli C40_11
Escherichia coli 98NK2
Escherichia coli C418_89
Escherichia coli 99.0670
Escherichia coli C458_10
Escherichia coli 99.0672
Escherichia coli C48807
Escherichia coli 99.0678
Escherichia coli C496_10
Escherichia coli 99.0713
Escherichia coli C497_10
Escherichia coli 99.0741
Escherichia coli C527_94
Escherichia coli 99.0814
Escherichia coli C54-58 (lb)
Escherichia coli 99.0815
Escherichia coli C581_05
Escherichia coli 99.0816
Escherichia coli C586_05
Escherichia coli 99.0839
Escherichia coli C58_11
Escherichia coli 99.0848
Escherichia coli C595_09
Escherichia coli 99.1753
Escherichia coli C639_08
Escherichia coli 99.1762
Escherichia coli C652_10
Escherichia coli 99.1775
Escherichia coli C654_09
Escherichia coli 99.1781
Escherichia coli C666_01
Escherichia coli 99.1793
Escherichia coli C691-71 (14b)
Escherichia coli 99.1805
Escherichia coli C717_10
Escherichia coli A-03_34
Escherichia coli C725_88
Escherichia coli A25922R
Escherichia coli C732_98
Escherichia coli A35218R
Escherichia coli C743_03
Escherichia coli A9619-c2 (11c)
Escherichia coli C751_03
Escherichia coli AA86
Escherichia coli C77_OS
Escherichia coli AB42410445-isolate1
Escherichia coli C78_09C
Escherichia coli AB4255441 8-isolate1
Escherichia coli C792_92
Escherichia coli AB42602061 -isolate1
Escherichia coli C796_10
Escherichia coli AB43739056-isolate1
Escherichia coli C799_92
Escherichia coli ABU 83972
Escherichia coli C79_08
Escherichia coli AD30
Escherichia coli C807_09
Escherichia coli ADL-218
Escherichia coli C80_08
Escherichia coli ADL-223
Escherichia coli C824_10
Escherichia coli ADL-226
Escherichia coli C82_11
Escherichia coli ADL-304
Escherichia coli C838_10
Escherichia coli ADL-305
Escherichia coli C842_97
Escherichia coli ADL-306
Escherichia coli C844_97
Escherichia coli ADL-307
Escherichia coli ADL-309
Escherichia coli ADL-308
Escherichia coli ADL-310
Escherichia coli 9.1796
Escherichia coli ADL-311
Escherichia coli 90.0039
Escherichia coli ADL-312
Escherichia coli 90.0091
Escherichia coli ADL-313
Escherichia coli 90.2281
Escherichia coli ADL-314
Escherichia coli 900105 (10e)
Escherichia coli ADL-316
Escherichia coli 902034 (7b)
Escherichia coli ADL-324
Escherichia coli 907357
Escherichia coli ADL-327
Escherichia coli 907391
Escherichia coli AI27
Escherichia coli 907446
Escherichia coli APEC IMT5155
Escherichia coli 907672
Escherichia coli APEC 01
Escherichia coli 907700
Escherichia coli APEC 078
Escherichia coli 907701
Escherichia coli ARL10/167
Escherichia coli 907710
Escherichia coli ARS4.2123
Escherichia coli 907713
Escherichia coli ATCC 25922
Escherichia coli 907715
Escherichia coli ATCC 35150
Escherichia coli 907779
Escherichia coli B
Escherichia coli 907889
Escherichia coli B str. REL606
Escherichia coli 907892
Escherichia coli B str. REL607
Escherichia coli 908519
Escherichia coli B-04_28
Escherichia coli 908521
Escherichia coli B088
Escherichia coli 908522
Escherichia coli B093
Escherichia coli 908524
Escherichia coli B102
Escherichia coli 908525
Escherichia coli B103
Escherichia coli 908541
Escherichia coli B104
Escherichia coli 908555
Escherichia coli B105
Escherichia coli 908573
Escherichia coli B106
Escherichia coli 908585
Escherichia coli B107
Escherichia coli C33_11
Escherichia coli B108
Escherichia coli C341_10
Escherichia coli B109
Escherichia coli C343_08
Escherichia coli B112
Escherichia coli C347_93
Escherichia coli B113
Escherichia coli C353_09
Escherichia coli B114
Escherichia coli C354_03B
Escherichia coli B1167
Escherichia coli 909957
Escherichia coli BIDMC 39
Escherichia coli 910096-2
Escherichia coli BIDMC 6
Escherichia coli 92.0144 (F03)
Escherichia coli BIDMC 9
Escherichia coli 929-78
Escherichia coli BL21
Escherichia coli B185
Escherichia coli BL21(DE3)
Escherichia coli B26-1
Escherichia coli BWH 24
Escherichia coli B26-2
Escherichia coli BWII 32
Escherichia coli B28-1
Escherichia coli BWH 34
Escherichia coli B28-2
Escherichia coli BWH 40
Escherichia coli B29-1
Escherichia coli C
Escherichia coli B29-2
Escherichia coli ATCC 8739
Escherichia coli B354
Escherichia coli C-04_22
Escherichia coli B36-1
Escherichia coli C-34666
Escherichia coli B36-2
Escherichia coli C1214 90
Escherichia coli B367
Escherichia coli C1244 91
Escherichia coli B40-1
Escherichia coli C12_92
Escherichia coli B40-2
Escherichia coli C154_11
Escherichia coli B41
Escherichia coli C155_11
Escherichia coli B49-1
Escherichia coli C157_11
Escherichia coli B49-2
Escherichia coli C161_11
Escherichia coli B5-1
Escherichia coli C166_11
Escherichia coli B5-2
Escherichia coli C170_11
Escherichia coli B574
Escherichia coli C186-61 (10h)
Escherichia coli B671
Escherichia coli C2139_99
Escherichia coli B7-1
Escherichia coli C213_10
Escherichia coli B7-2
Escherichia coli C238_91
Escherichia coli B706
Escherichia coli C240-52 (9c)
Escherichia coli B799
Escherichia coli C260_92
Escherichia coli B7A
Escherichia coli C262_10
Escherichia coli B83
Escherichia coli C283_09
Escherichia coli B84
Escherichia coli C295_10
Escherichia coli B85
Escherichia coli C309-64 (lOg)
Escherichia coli B86
Escherichia coli DH5[alpha]
Escherichia coli B89
Escherichia coli DSM 30083 = JCM 1649
Escherichia coli B90
Escherichia coli E-01_37
Escherichia coli B91
Escherichia coli E1002
Escherichia coli B92
Escherichia coli E101
Escherichia coli B921
Escherichia coli E110019
Escherichia coli B93
Escherichia coli E1114
Escherichia coli B94
Escherichia coli E1118
Escherichia coli B95
Escherichia coli E1167
Escherichia coli Bal225
Escherichia coli E128010
Escherichia coli BCE001_MS16
Escherichia coli E1492
Escherichia coli BCE002_MS12
Escherichia coli E1520
Escherichia coli BCE006_MS-23
Escherichia coli E1777
Escherichia coli BCE007_MS-11
Escherichia coli E2265
Escherichia coli BCE008_MS-01
Escherichia coli E24377A
Escherichia coli BCE008_MS-13
Escherichia coli E267
Escherichia coli BCEO11_MS-01
Escherichia coli E482
Escherichia coli BCEO19_MS-13
Escherichia coli E560
Escherichia coli BCE030_MS-09
Escherichia coli E704
Escherichia coli BCE032-DM-A
Escherichia coli E74/68
Escherichia coli BCE032-DM-B
Escherichia coli E851/71
Escherichia coli BCE032-DM-B-A
Escherichia coli Ec 1 1-9450
Escherichia coli BCE032-DM-B-B
Escherichia coli Ec 11-9941
Escherichia coli BCE032 MS-12
Escherichia coli Ec 11-9990
Escherichia coli BCE034 MS-14
Escherichia coli EC096/10
Escherichia coli Bd5610_99
Escherichia coli Eel 1-4986
Escherichia coli B1DMC 15
Escherichia coli ECT734
Escherichia coli BIDMC 17A
Escherichia coli EC1735
Escherichia coli BIDMC 17B
Escherichia coli EC1736
Escherichia coli BIDMC 19A
Escherichia coli EC1737
Escherichia coli BIDMC 19B
Escherichia coli EC 1738
Escherichia coli BIDMC 19C
Escherichia coli EC1845
Escherichia coli BIDMC 20A
Escherichia coli EC 1846
Escherichia coli BIDMC 20B
Escherichia coli EC 1847
Escherichia coli BIDMC 2B
Escherichia coli EC 1848
Escherichia coli BIDMC 3
Escherichia coli EC 1849
Escherichia coli BIDMC 37
Escherichia coli EC1850
Escherichia coli BIDMC 38
Escherichia coli EC1856
Escherichia coli EC 1862
Escherichia coli FR1K920
Escherichia coli EC 1863
Escherichia coli FVEC1302
Escherichia coli EC 1864
Escherichia coli FVEC1412
Escherichia coli EC 1865
Escherichia coli FVEC1465
Escherichia coli EC 1866
Escherichia coli G5101
Escherichia coli EC 1868
Escherichia coli G58-1
Escherichia coli EC 1869
Escherichia coli GEMS_EPEC1
Escherichia coli EC 1870
Escherichia coli H001
Escherichia coli EC302/04
Escherichia coli H120
Escherichia coli EC4013
Escherichia coli H16
Escherichia coli EC4100B
Escherichia coli H185
Escherichia coli EC4196
Escherichia coli H218
Escherichia coli EC4203
Escherichia coli H220
Escherichia coli EC4402
Escherichia coli H223
Escherichia coli EC4421
Escherichia coli H252
Escherichia coli EC4422
Escherichia coli H260
Escherichia coli EC4436
Escherichia coli C87_11
Escherichia coli EC4437
Escherichia coli C887_10
Escherichia coli EC4439
Escherichia coli C900_01
Escherichia coli EC4448
Escherichia coli C93_11
Escherichia coli EC96038
Escherichia coli C9_92
Escherichia coli ECA-0157
Escherichia coli CB7326
Escherichia coli ECA-727
Escherichia coli B15
Escherichia coli ECC-1470
Escherichia coli B17
Escherichia coli ECC-7
Escherichia coli B171
Escherichia coli EcN DM1
Escherichia coli B175
Escherichia coli ED la
Escherichia coli CE418
Escherichia coli EDM 106
Escherichia coli CE516
Escherichia coli EDM 116
Escherichia coli CE549
Escherichia coli EDM530
Escherichia coli CFT073
Escherichia coli Envira 10/1
Escherichia coli chi7122
Escherichia coli Envira 8/11
Escherichia coli cloneA_il
Escherichia coli EPEC 32/73
Escherichia coli Combat2D2
Escherichia coli EPEC C342-62
Escherichia coli CTJMT8
Escherichia coli EPEC 11
Escherichia coli D-04_27
Escherichia coli EPECa12
Escherichia coli DEC10A
Escherichia coli EPECa14
Escherichia coli DEC 10B
Escherichia coli ER2796
Escherichia coli DEC10C
Escherichia coli ES699
Escherichia coli DEC10D
Escherichia coli ETEC 1392/75
Escherichia coli DEC10E
Escherichia coli ETEC DS168-1
Escherichia coli DEC 1 OF
Escherichia coli ETEC HI0407
Escherichia coli DEC11A
Escherichia coli H10407_1968
Escherichia coli DEC11B
Escherichia coli HI0407_1970
Escherichia coli DEC11C
Escherichia coli ETEC TW03439
Escherichia coli DEC11D
Escherichia coli ETEC TW03452
Escherichia coli DEC11E
Escherichia coli ETEC TW03574
Escherichia coli DEC12A
Escherichia coli ETEC TW03576
Escherichia coli DEC12B
Escherichia coli ETEC TW03585
Escherichia coli DEC12C
Escherichia coli ETEC TW03741
Escherichia coli DEC12D
Escherichia coli ETEC TW 14691
Escherichia coli DEC12E
Escherichia coli ETEC WS1896A
Escherichia coli DEC13A
Escherichia coli ETEC WS2068A
Escherichia coli DEC13B
Escherichia coli ETEC WS3080A
Escherichia coli DEC13C
Escherichia coli F11
Escherichia coli DEC13D
Escherichia coli F18+
Escherichia coli DEC13E
Escherichia coli F576
Escherichia coli DEC14A
Escherichia coli FDA504
Escherichia coli DEC14B
Escherichia coli FDA505
Escherichia coli DEC14C
Escherichia coli FDA506
Escherichia coli DEC14D
Escherichia coli FDA507
Escherichia coli DEC15A
Escherichia coli FDA517
Escherichia coli DEC15B
Escherichia coli FREP
Escherichia coli DECT5C
Escherichia coli FRIK1985
Escherichia coli DEC15D
Escherichia coli FRIK1990
Escherichia coli DEC15E
Escherichia coli FRIK1996
Escherichia coli DEC1A
Escherichia coli FRIK1997
Escherichia coli DECTB
Escherichia coli FRIK1999
Escherichia coli DEC1C
Escherichia coli FRIK2001
Escherichia coli DEC ID
Escherichia coli FRIK523
Escherichia coli DEC1E
Escherichia coli DEC2A
Escherichia coli HVH 223 (4-2976528)
Escherichia coli DEC2B
Escherichia coli HVH 225 (4-1273116)
Escherichia coli DEC2C
Escherichia coli HVH 227 (4-2277670)
Escherichia coli DEC2D
Escherichia coli HVH 228 (4-7787030)
Escherichia coli DEC2E
Escherichia coli HVH 23 (4-6066488)
Escherichia coli DEC3A
Escherichia coli HVH 24 (4-5985145)
Escherichia coli DEC3B
Escherichia coli IIVII 25 (4-5851939)
Escherichia coli DEC3C
Escherichia coli HVH 26 (4-5703913)
Escherichia coli DEC3D
Escherichia coli HVH 27 (4-7449267)
Escherichia coli DEC3E
Escherichia coli HVH 28 (4-0907367)
Escherichia coli DEC3F
Escherichia coli HVH 29 (4-3418073)
Escherichia coli DEC4A
Escherichia coli HVH 3 (4-7276001)
Escherichia coli DEC4B
Escherichia coli HVH 30 (4-2661829)
Escherichia coli DEC4C
Escherichia coli HVH 31 (4-2602156)
Escherichia coli DEC4D
Escherichia coli HVH 32 (4-3773988)
Escherichia coli DEC4E
Escherichia coli HVH 33 (4-2174936)
Escherichia coli DEC4F
Escherichia coli HVH 35 (4-2962667)
Escherichia coli DEC5A
Escherichia coli HVH 36 (4-5675286)
Escherichia coli DEC5B
Escherichia coli HVH 37 (4-2773848)
Escherichia coli DEC5C
Escherichia coli HVH 38 (4-2774682)
Escherichia coli DEC5D
Escherichia coli HVH 39 (4-2679949)
Escherichia coli DEC5E
Escherichia coli HVH 4 (4-7276109)
Escherichia coli DEC6A
Escherichia coli HVH 40 (4-1219782)
Escherichia coli DEC6B
Escherichia coli HVH 41 (4-2677849)
Escherichia coli DEC6C
Escherichia coli HVH 42 (4-21 00061)
Escherichia coli DEC6D
Escherichia coli HVH 43 (4-2173468)
Escherichia coli DEC6E
Escherichia coli HVH 44 (4-2298570)
Escherichia coli DEC7A
Escherichia coli HVH 45 (4-3129918)
Escherichia coli DEC7B
Escherichia coli HVH 46 (4-2758776)
Escherichia coli DEC7C
Escherichia coli HVH 48 (4-2658593)
Escherichia coli DEC7D
Escherichia coli HVH 5 (4-7148410)
Escherichia coli DEC7E
Escherichia coli HVH 50 (4-2593475)
Escherichia coli DEC8A
Escherichia coli HVH 51 (4-2172526)
Escherichia coli DEC8B
Escherichia coli HVH 53 (4-0631051)
Escherichia coli DEC8C
Escherichia coli HVH 54 (4-2723514)
Escherichia coli DEC8D
Escherichia coli IIVII 55 (4-2646161)
Escherichia coli DEC8E
Escherichia coli HVH 56 (4-2153033)
Escherichia coli DEC9A
Escherichia coli HVH 58 (4-2839709)
Escherichia coli DEC9B
Escherichia coli HVH 59 (4-1119338)
Escherichia coli DEC9C
Escherichia coli IIVII 6 (3-8296502)
Escherichia coli DEC9D
Escherichia coli HVH 61 (4-2736020)
Escherichia coli DEC9E
Escherichia coli HVH 63 (4-2542528)
Escherichia coli DH1
Escherichia coli HVH 65 (4-2262045)
Escherichia coli HVH 199 (4-5670322)
Escherichia coli HVH 68 (4-0888028)
Escherichia coli HVH 2 (4-6943160)
Escherichia coli HVH 69 (4-2837072)
Escherichia coli HVH 20 (4-5865042)
Escherichia coli HVH 7 (4-7315031)
Escherichia coli HVH 200 (4-4449924)
Escherichia coli HVH 70 (4-2963531)
Escherichia coli HVH 201 (4-4459431)
Escherichia coli HVH 73 (4-2393174)
Escherichia coli HVH 202 (4-3163997)
Escherichia coli HVH 74 (4-1034782)
Escherichia coli HVH 203 (4-3126218)
Escherichia coli HVH 76 (4-2538717)
Escherichia coli HVH 204 (4-3112802)
Escherichia coli HVH 77 (4-2605759)
Escherichia coli HVH 205 (4-3094677)
Escherichia coli HVH 78 (4-2735946)
Escherichia coli HVH 206 (4-3128229)
Escherichia coli HVH 79 (4-2512823)
Escherichia coli HVH 207 (4-3113221)
Escherichia coli HVH 80 (4-2428830)
Escherichia coli HVH 208 (4-3112292)
Escherichia coli HVH 82 (4-2209276)
Escherichia coli HVH 209 (4-3062651)
Escherichia coli HVH 83 (4-2051087)
Escherichia coli HVH 21 (4-4517873)
Escherichia coli HVH 84 (4-1021478)
Escherichia coli HVH 21 0 (4-3042480)
Escherichia coli HVH 85 (4-0792144)
Escherichia coli HVH 211 (4-3041891)
Escherichia coli HVH 86 (4-7026218)
Escherichia coli HVH 212 (3-9305343)
Escherichia coli HVH 87 (4-5977630)
Escherichia coli HVH 213 (4-3042928)
Escherichia coli HVH 88 (4-5854636)
Escherichia coli HVH 214 (4-3062198)
Escherichia coli HVH 89 (4-5885604)
Escherichia coli HVH 215 (4-3008371)
Escherichia coli HVH 9 (4-6942539)
Escherichia coli HVH 216 (4-3042952)
Escherichia coli HVH 90 (4-3191362)
Escherichia coli HVH 217 (4-1022806)
Escherichia coli HVH 91 (4-4638751)
Escherichia coli HVH 218 (4-4500903)
Escherichia coli HVH 92 (4-5930790)
Escherichia coli HVH 22 (4-2258986)
Escherichia coli HVH 93 (4-5851025)
Escherichia coli HVH 220 (4-5876842)
Escherichia coli HVH 95 (4-6074464)
Escherichia coli IIVII 221 (4-3136817)
Escherichia coli IIVII 96 (4-5934869)
Escherichia coli HVH 222 (4-2977443)
Escherichia coli HVH 97 (4-6859038)
Escherichia coli HVH 98 (4-5799287)
Escherichia coli KTE115
Escherichia coli HVH 99 (4-6745172)
Escherichia coli KTE116
Escherichia coli IAI1
Escherichia coli KTE117
Escherichia coli IAI39
Escherichia coli KTE118
Escherichia coli IHE3034
Escherichia coli KTE119
Escherichia coli IMT8073
Escherichia coli KTE12
Escherichia coli J53
Escherichia coli KTE120
Escherichia coli J96
Escherichia coli KTE121
Escherichia coli JB1-95
Escherichia coli KTE122
Escherichia coli JC2722
Escherichia coli KTE123
Escherichia coli JC5048
Escherichia coli KTE124
Escherichia coli JCL16
Escherichia coli KTE125
Escherichia coli JCMA
Escherichia coli KTE126
Escherichia coli Jurua 18/11
Escherichia coli KTE127
Escherichia coli Jurua 20/10
Escherichia coli KTE128
Escherichia coli K-12
Escherichia coli KTE129
Escherichia coli BW25113
Escherichia coli KTE13
Escherichia coli BW2952
Escherichia coli KTE130
Escherichia coli BW38028
Escherichia coli KTE131
Escherichia coli LW1655F+
Escherichia coli KTE132
Escherichia coli MC1061
Escherichia coli KTEI33
Escherichia coli NC-7
Escherichia coli KTE134
Escherichia coli str. K-12 substr. DH10B
Escherichia coli KTE135
Escherichia coli str. K-12 substr. MDS42
Escherichia coli KTE136
Escherichia coli str. K-12 substr. MG1655
Escherichia coli KTEI37
Escherichia coli str. K-12 substr. W3110
Escherichia coli KTE138
Escherichia coli Kl
Escherichia coli KTE139
Escherichia coli K2
Escherichia coli KTE14
Escherichia coli K71
Escherichia coli KTE140
Escherichia coli KD1
Escherichia coli KTE141
Escherichia coli KD2
Escherichia coli KTE142
Escherichia coli KO11FL
Escherichia coli KTE143
Escherichia coli KOEGE 10 (25a)
Escherichia coli KTE144
Escherichia coli KOEGE 118 (317a)
Escherichia coli KTE145
Escherichia coli KOEGE 131 (358a)
Escherichia coli KTE146
Escherichia coli KOEGE 3 (4a)
Escherichia coli KTE147
Escherichia coli KOEGE 30 (63a)
Escherichia coli KTE148
Escherichia coli KOEGE 32 (66a)
Escherichia coli KTE149
Escherichia coli KOEGE 33 (68a)
Escherichia coli KTE15
Escherichia coli KOEGE 40 (102a)
Escherichia coli KTE150
Escherichia coli KOEGE 43 (105a)
Escherichia coli KTE153
Escherichia coli KOEGE 44 (106a)
Escherichia coli KTE154
Escherichia coli KOEGE 56 (169a)
Escherichia coli KTE155
Escherichia coli KOEGE 58 (171a)
Escherichia coli KTE156
Escherichia coli KOEGE 61 (174a)
Escherichia coli KTE157
Escherichia coli KOEGE 62 (175a)
Escherichia coli KTE158
Escherichia coli KOEGE 68 (182a)
Escherichia coli KTE159
Escherichia coli KOEGE 7 (16a)
Escherichia coli KTE16
Escherichia coli KOEGE 70 (185a)
Escherichia coli KTE160
Escherichia coli KOEGE 71 (186a)
Escherichia coli KTE161
Escherichia coli KOEGE 73 (195a)
Escherichia coli KTE162
Escherichia coli KOEGE 77 (202a)
Escherichia coli KTE163
Escherichia coli KTE1
Escherichia coli KTE165
Escherichia coli KTE10
Escherichia coli KTE166
Escherichia coli KTE100
Escherichia coli KTE167
Escherichia coli KTE101
Escherichia coli KTE168
Escherichia coli KTE102
Escherichia coli KTE169
Escherichia coli KTE1 03
Escherichia coli KTE1 7
Escherichia coli KTE104
Escherichia coli KTE170
Escherichia coli KTE105
Escherichia coli KTE171
Escherichia coli KTE106
Escherichia coli KTE172
Escherichia coli KTE107
Escherichia coli KTE173
Escherichia coli KTE108
Escherichia coli KTE174
Escherichia coli KTE109
Escherichia coli KTE175
Escherichia coli KTE11
Escherichia coli KTE176
Escherichia coli KTE110
Escherichia coli KTE177
Escherichia coli KTE111
Escherichia coli KTE178
Escherichia coli KTE112
Escherichia coli KTE179
Escherichia coli KTE113
Escherichia coli KTE18
Escherichia coli KTE114
Escherichia coli KTE180
Escherichia coli KTE181
Escherichia coli H489
Escherichia coli KTE182
Escherichia coli H494
Escherichia coli KTE183
Escherichia coli H504
Escherichia coli KTE184
Escherichia coli H588
Escherichia coli KTE185
Escherichia coli H591
Escherichia coli KTE186
Escherichia coli H593
Escherichia coli KTE187
Escherichia coli II605
Escherichia coli KTE188
Escherichia coli H617
Escherichia coli KTE189
Escherichia coli H660
Escherichia coli KTE19
Escherichia coli H730
Escherichia coli KTE190
Escherichia coli H736
Escherichia coli KTE191
Escherichia coli HB101
Escherichia coli KTE192
Escherichia coli HM26
Escherichia coli KTE193
Escherichia coli HM27
Escherichia coli KTE194
Escherichia coli HM46
Escherichia coli KTE195
Escherichia coli HM605
Escherichia coli KTE196
Escherichia coli HM65
Escherichia coli KTE197
Escherichia coli HM69
Escherichia coli KTE198
Escherichia coli HP20A2007
Escherichia coli KTE199
Escherichia coli HUSEC41
Escherichia coli KTE2
Escherichia coli HVH 1 (4-6876161)
Escherichia coli KTE20
Escherichia coli HVH 10 (4-6832164)
Escherichia coli KTE200
Escherichia coli HVH 100 (4-2850729)
Escherichia coli KTE201
Escherichia coli HVH 101 (4-6859844)
Escherichia coli KTE202
Escherichia coli HVH 102 (4-6906788)
Escherichia coli KTE203
Escherichia coli HVH 103 (4-5904188)
Escherichia coli KTE204
Escherichia coli HVH 104 (4-6977960)
Escherichia coli KTE205
Escherichia coli HVH 105 (4-6748473)
Escherichia coli KTE206
Escherichia coli HVH 106 (4-6881831)
Escherichia coli KTE207
Escherichia coli HVH 107 (4-5860571)
Escherichia coli KTE208
Escherichia coli HVH 108 (4-6924867)
Escherichia coli KTE209
Escherichia coli HVH 109 (4-6977162)
Escherichia coli KTE21
Escherichia coli HVH 110 (4-6978754)
Escherichia coli KTE210
Escherichia coli HVH 111 (4-7039018)
Escherichia coli KTE211
Escherichia coli HVH 112 (4-5987253)
Escherichia coli KTE212
Escherichia coli HVH 113 (4-7535473)
Escherichia coli KTE213
Escherichia coli HVH 114 (4-7037740)
Escherichia coli KTE214
Escherichia coli HVH 115 (4-4465989)
Escherichia coli KTE215
Escherichia coli HVH 115 (4-4465997)
Escherichia coli KTE216
Escherichia coli HVH 116 (4-6879942)
Escherichia coli KTE217
Escherichia coli HVH 117 (4-6857191)
Escherichia coli KTE218
Escherichia coli HVH 118 (4-7345399)
Escherichia coli KTE219
Escherichia coli HVH 119 (4-6879578)
Escherichia coli KTE22
Escherichia coli HVH 12 (4-7653042)
Escherichia coli KTE220
Escherichia coli HVH 120 (4-6978681)
Escherichia coli KTE221
Escherichia coli HVH 121 (4-6877826)
Escherichia coli KTE222
Escherichia coli HVH 122 (4-6851606)
Escherichia coli KTE223
Escherichia coli HVH 125 (4-2634716)
Escherichia coli KTE224
Escherichia coli HVH 126 (4-6034225)
Escherichia coli KTE225
Escherichia coli HVH 127 (4-7303629)
Escherichia coli KTE226
Escherichia coli HVH 128 (4-7030436)
Escherichia coli KTE227
Escherichia coli HVH 13 (4-7634056)
Escherichia coli KTE228
Escherichia coli HVH 130 (4-7036876)
Escherichia coli KTE229
Escherichia coli HVH 132(4-6876862)
Escherichia coli KTE23
Escherichia coli HVH 133 (4-4466519)
Escherichia coli H263
Escherichia coli HVH 134 (4-6073441)
Escherichia coli H288
Escherichia coli HVH 135 (4-4449320)
Escherichia coli H296
Escherichia coli HVH 136(4-5970458)
Escherichia coli H299
Escherichia coli HVH 137 (4-2124971)
Escherichia coli H30
Escherichia coli HVH 138 (4-6066704)
Escherichia coli H305
Escherichia coli HVH 139 (4-3192644)
Escherichia coli H378
Escherichia coli HVH 140(4-5894387)
Escherichia coli H383
Escherichia coli HVH 141 (4-5995973)
Escherichia coli H3 86
Escherichia coli HVH 142 (4-5627451)
Escherichia coli H397
Escherichia coli HVH 143 (4-5674999)
Escherichia coli H413
Escherichia coli HVH 144 (4-4451937)
Escherichia coli H420
Escherichia coli HVH 145 (4-5672112)
Escherichia coli H442
Escherichia coli HVH 146 (4-3189767)
Escherichia coli II454
Escherichia coli HVH 147 (4-5893887)
Escherichia coli H461
Escherichia coli HVH 148 (4-3192490)
Escherichia coli HVH 149 (4-4451880)
Escherichia coli MP021552.12
Escherichia coli HVH 150 (4-3258106)
Escherichia coli MP021552.7
Escherichia coli HVH 151 (4-5755573)
Escherichia coli MP021552.8
Escherichia coli HVH 152 (4-3447545)
Escherichia coli MP021561.2
Escherichia coli HVH 153 (3-9344314)
Escherichia coli MP021561.3
Escherichia coli HVH 154 (4-5636698)
Escherichia coli MP021566.1
Escherichia coli IIVII 155 (4-4509048)
Escherichia coli MP 1
Escherichia coli HVH 156 (4-3206505)
Escherichia coli MS 107-1
Escherichia coli HVH 157 (4-3406229)
Escherichia coli MS 110-3
Escherichia coli HVH 158 (4-3224287)
Escherichia coli MS 115-1
Escherichia coli HVH 159 (4-5818141)
Escherichia coli MS 116-1
Escherichia coli HVH 16 (4-7649002)
Escherichia coli MS 117-3
Escherichia coli HVH 160 (4-5695937)
Escherichia coli MS 119-7
Escherichia coli HVH 161 (4-3119890)
Escherichia coli MS 124-1
Escherichia coli HVH 162 (4-5627982)
Escherichia coli MS 145-7
Escherichia coli HVH 163 (4-4697553)
Escherichia coli MS 146-1
Escherichia coli HVH 164 (4-5953081)
Escherichia coli MS 153-1
Escherichia coli HVH 167 (4-6073565)
Escherichia coli MS 16-3
Escherichia coli HVH 169 (4-1075578)
Escherichia coli MS 175-1
Escherichia coli HVH 17 (4-7473087)
Escherichia coli MS 182-1
Escherichia coli HVH 170 (4-3026949)
Escherichia coli MS 185-1
Escherichia coli HVH 171 (4-3191958)
Escherichia coli MS 187-1
Escherichia coli HVH 172 (4-3248542)
Escherichia coli MS 196-1
Escherichia coli HVH 173 (3-9175482)
Escherichia coli MS 198-1
Escherichia coli HVH 175 (4-3405184)
Escherichia coli MS 200-1
Escherichia coli HVH 176 (4-3428664)
Escherichia coli MS 21-1
Escherichia coli HVH 177 (4-2876612)
Escherichia coli MS 45-1
Escherichia coli HVH 178 (4-3189163)
Escherichia coli MS 57-2
Escherichia coli HVH 18 (4-8589585)
Escherichia coli MS 60-1
Escherichia coli HVH 180 (4-3051617)
Escherichia coli MS 69-1
Escherichia coli HVH 182 (4-0985554)
Escherichia coli MS 78-1
Escherichia coli HVH 183 (4-3205932)
Escherichia coli MS 79-10
Escherichia coli HVH 184 (4-3343286)
Escherichia coli MS 84-1
Escherichia coli HVH 185 (4-2876639)
Escherichia coli MS 85-1
Escherichia coli HVH 186 (4-3405044)
Escherichia coli N1
Escherichia coli IIVII 187 (4-4471660)
Escherichia coli NA114
Escherichia coli HVH 188 (4-2356988)
Escherichia coli NC101
Escherichia coli HVH 189 (4-3220125)
Escherichia coli NCCP 15653
Escherichia coli HVH 19 (4-7154984)
Escherichia coli NCCP 15655
Escherichia coli IIVII 190 (4-3255514)
Escherichia coli NCCP 15656
Escherichia coli HVH 191 (3-9341900)
Escherichia coli NCCP15647
Escherichia coli HVH 192 (4-3054470)
Escherichia coli NCCP 15648
Escherichia coli HVH 193 (4-3331423)
Escherichia coli NCCP 15657
Escherichia coli HVH 194 (4-2356805)
Escherichia coli NCCP 15658
Escherichia coli HVH 195 (3-7155360)
Escherichia coli NCTC 86
Escherichia coli HVH 196 (4-4530470)
Escherichia coli NDMlDok01
Escherichia coli HVH 197 (4-4466217)
Escherichia coli NE037
Escherichia coli HVH 198 (4-3206106)
Escherichia coli NE098
Escherichia coli MA6
Escherichia coli NE1487
Escherichia coli MCI9
Escherichia coli Nissle 1917
Escherichia coli MC21
Escherichia coli NT:H19
Escherichia coli MC23
Escherichia coli NT:H40
Escherichia coli MC6002
Escherichia coli NU14
Escherichia coli MC6003
Escherichia coli O08
Escherichia coli MG1657
Escherichia coli O10
Escherichia coli MGR194
Escherichia coli O10 str. Bi8337-41
Escherichia coli MP020940.1
Escherichia coli O10EH33
Escherichia coli MP020980.1
Escherichia coli O103
Escherichia coli MP020980.2
Escherichia coli O103 str. RM10042
Escherichia coli MP021017.1
Escherichia coli O103 str. RM8385
Escherichia coli MP021017.10
Escherichia coli O103:H2
Escherichia coli MP021017.il
Escherichia coli E22
Escherichia coli MP021017.12
Escherichia coli O103:H2 str. 12009
Escherichia coli MP021017.2
Escherichia coli O103:H2 str. CVM9450
Escherichia coli MP021017.3
Escherichia coli O103:H25
Escherichia coli MP021017.4
Escherichia coli O103:H25 str. 6582
Escherichia coli MP021017.5
Escherichia coli O103:H25 str. CVM9340
Escherichia coli MP021017.6
Escherichia coli O103:H25 sir. NIPH-11060424
Escherichia coli MP021017.9
Escherichia coli O103:IINM
Escherichia coli MP021552.11
Escherichia coli O103:K+
Escherichia coii O104:H12
Escherichia coli O109:H9
Escherichia coli O104:H21
Escherichia coli O10:K5(L):H4
Escherichia coli O104:H21 str. CFSAN002236
Escherichia coli O10:K5(L):H4 str. ATCC 23506
Escherichia coli O104:H21 str. CFSAN002237
Escherichia coli O11
Escherichia coli O104:H4
Escherichia coli O11 str. Bi632-42
Escherichia coli O104:H4 str. 01-09591
Escherichia coli O11 1
Escherichia coli O104:114 str. 04-8351
Escherichia coli O11 1 str. RM9322
Escherichia coli O104:H4 str. 09-7901
Escherichia coli O111:B4
Escherichia coli O104:H4 str. 11-02030
Escherichia coli O111:H−
Escherichia coli O104:H4 str. 11-02033-1
Escherichia coli O111:H− str. 11128
Escherichia coli O104:H4 str. 11-02092
Escherichia coli O111:H11
Escherichia coli O104:H4 str. 11-02093
Escherichia coli O111:H11 str. CFSAN001630
Escherichia coli O104:H4 str. 11-02281
Escherichia coli O111H11 str. CVM9455
Escherichia coli O104:H4 str. 11-02318
Escherichia coli O111:H11 str. CVM9534
Escherichia coli O104:H4 str. 11-02913
Escherichia coli O111:H11 str. CVM9545
Escherichia coli O104:H4 sir. 11-03439
Escherichia coli O111:H11 sir. CVM9553
Escherichia coli O104:H4 str. 11-03943
Escherichia coli O111:H19
Escherichia coli O104:H4 str. 11-04080
Escherichia coli O111:H2
Escherichia coli O104:H4 str. 11-3677
Escherichia coli O111:H21
Escherichia coli O104:H4 str. 11-3798
Escherichia coli O111:H21 str. 226
Escherichia coli O1 04:H4 str. 11-4404
Escherichia coli O111:H8
Escherichia coli O104:H4 str. 11-4522
Escherichia coli O111:H8 str. 1074
Escherichia coli O104:H4 str. 11-4623
Escherichia coli O111:H8 str. 9662
Escherichia coli O104:H4 str. 11-4632 CI
Escherichia coli O111:H8 str. CFSAN001632
Escherichia coli O104:H4 str. 1 1-4632 C2
Escherichia coli O111:H8 str. CVM9570
Escherichia coli O104:H4 str. 11-4632 C3
Escherichia coli O111:H8 str. CVM9574
Escherichia coli O104:H4 str. 11-4632 C4
Escherichia coli O111:H8 str. CVM9602
Escherichia coli O104:H4 str. 11-4632 C5
Escherichia coli O111:H8 str. CVM9634
Escherichia coli O104:H4 str. 2009EL-2050
Escherichia coli O111:NM
Escherichia coli O104:H4 str. 2009EL-2071
Escherichia coli O113
Escherichia coli O104:H4 str. 2011C-3493
Escherichia coli O113:H19
Escherichia coli O104:H4 str. C227-11
Escherichia coli O113:H21
Escherichia coli O104:H4 str. C236-11
Escherichia coli O113:H21 str. CL-3
Escherichia coli O104:H4 str. C237-11
Escherichia coli O115:H−
Escherichia coli O104:H4 str. E101/11
Escherichia coli O115:HMN
Escherichia coli O104:114 str. E103/11
Escherichia coli O115:K+
Escherichia coli O104:H4 str. E107/11
Escherichia coli O117:Kl:H7
Escherichia coli O104:H4 str. El 12/10
Escherichia coli O119:H6
Escherichia coli O104:H4 str. E83/11
Escherichia coli O119:UT
Escherichia coli O104:114 str. E84/11
Escherichia coli O120:IINM
Escherichia coli O104:H4 str. E90/11
Escherichia coli O121
Escherichia coli O104:H4 str. E92/11
Escherichia coli O121 str. RM8352
Escherichia coli O104:H4 str. E94/11
Escherichia coli O12EH19
Escherichia coli O104:H4 str. Eel 1-4984
Escherichia coli O12EH19 str. 9918
Escherichia coli O104:H4 str. Eel 1-4986
Escherichia coli O12EH19 str. MT#2
Escherichia coli O104:H4 str. Eel 1-4987
Escherichia coli O12EH46
Escherichia coli O104:H4 str. Eel 1-4988
Escherichia coli O124:H−
Escherichia coli O104:H4 str. Eel 1-5536
Escherichia coli O124:H40
Escherichia coli O104:H4 str. Eel 1-5537
Escherichia coli O126:H27
Escherichia coli O104:H4 str. Eel 1-5538
Escherichia coli O127:B8
Escherichia coli O104:H4 str. Eel 1-5603
Escherichia coli O127:H21
Escherichia coli O104:H4 str. Eel 1-5604
Escherichia coli O127:H27
Escherichia coli O104:H4 str. Eel 1-6006
Escherichia coli O127:H27 str. C43/90
Escherichia coli O104:Ft4 str. Eel 1 -9450
Escherichia coli O127:H6
Escherichia coli O104:H4 str. Eel 1-9941
Escherichia coli O127:H6 str. E2348/69
Escherichia coli O104:H4 str. Eel 1-9990
Escherichia coli O127a:H6
Escherichia coli O104:H4 str. Eel2-0465
Escherichia coli O128:H2
Escherichia coli O104:H4 str. Eel 2-0466
Escherichia coli O131:H25
Escherichia coli O104:H4 str. GOS1
Escherichia coli O136:H−
Escherichia coli O104:H4 sir. GOS2
Escherichia coli O138:NM
Escherichia coli O104:H4 str. HI 12180280
Escherichia coli O138:H11
Escherichia coli O104:H4 str. HI 12180282
Escherichia coli O142:H6
Escherichia coli O104:H4 str. HI 12180283
Escherichia coli O145
Escherichia coli O104:H4 str. HI 12180540
Escherichia coli O145 str. RM9872
Escherichia coli O104:H4 str. HI 12180541
Escherichia coli O145:H−
Escherichia coli O104:H4 str. LB226692
Escherichia coli O145:H28
Escherichia coli O104:H4 str. ON2010
Escherichia coli O145:H28 str. 4865/96
Escherichia coli O104:H4 str. ON2011
Escherichia coli O145:H28 str. RM12581
Escherichia coli O104:114 str. TY-2482
Escherichia coli O145:1128 str. RM12761
Escherichia coli O108:H25
Escherichia coli O145:H28 str. RM13514
Escherichia coli O145:H28 str. RM13516
Escherichia coli O157:H7 str. Sakai
Escherichia coli O145:NM
Escherichia coli O157:H7 str. SS17
Escherichia coli O145:NM str. 2012C-4474
Escherichia coli O157:H7 str. SS52
Escherichia coli O145:NM str. 2012C-4477
Escherichia coli O157:H7 str. TW14359
Escherichia coli O145:NM str. 2012C-4478
Escherichia coli O157:H7 str. TW14588
Escherichia coli O145:NM str. 2012C-4479
Escherichia coli O157:H7 str. ZAP430
Escherichia coli O145:NM str. 2012C-4480
Escherichia coli O157:119
Escherichia coli O145:NM str. 8235
Escherichia coli O157:HNM
Escherichia coli O149:H10
Escherichia coli O157:NM
Escherichia coli O153:H21
Escherichia coli O15:H34
Escherichia coli O153:H7
Escherichia coli O15:NM
Escherichia coli O154:H9
Escherichia coli O16
Escherichia coli O157
Escherichia coli O16 str. Fill 19-41
Escherichia coli 3.4880
Escherichia coli O169:H−
Escherichia coli 7.1982
Escherichia coli O17
Escherichia coli 95.0083
Escherichia coli O17 str. K12a
Escherichia coli ATCC 700728
Escherichia coli O174:H21
Escherichia coli O157 str. NCCP15738
Escherichia coli O177:H11
Escherichia coli O157 str. NCCP15739
Escherichia coli O18
Escherichia coli PA11
Escherichia coli O18 str. F10018-41
Escherichia coli PA13
Escherichia coli O180:H−
Escherichia coli PA19
Escherichia coli O19
Escherichia coli PA35
Escherichia coli O19 str. F8188-41
Escherichia coli O157:12
Escherichia coli O20
Escherichia coli O157:H−
Escherichia coli O20 str. P7a
Escherichia coli O157:H− str. 493-89
Escherichia coli O23
Escherichia coli O157:H− str. H 2687
Escherichia coli O23 str. P7a
Escherichia coli O157:H12
Escherichia coli O25
Escherichia coli O157:H16
Escherichia coli O25 str. E39a
Escherichia coli O157:H37
Escherichia coli O25b:H4
Escherichia coli O157:H39
Escherichia coli O25b:H4-ST131 str. EC958
Escherichia coli O157:H43
Escherichia coli O25b:ST131
Escherichia coli O157:H43 str. T22
Escherichia coli O26
Escherichia coli O157:H45
Escherichia coli O26 str. RM10386
Escherichia coli O157:H7
Escherichia coli O26 str. RM8426
Escherichia coli O157:117 str. 1044
Escherichia coli O26:11−
Escherichia coli O157:H7 str. 1125
Escherichia coli O26:H11
Escherichia coli O157:H7 str. 121
Escherichia coli O26:H11 str. 10140
Escherichia coli O157:H7 str. 262
Escherichia coli O26:H11 str. 11368
Escherichia coli O157:117 str. 611
Escherichia coli O26:1111 str. 6629
Escherichia coli O157:H7 str. EC10
Escherichia coli O26:H11 str. CFSAN001629
Escherichia coli O157:H7 str. EC1212
Escherichia coli O26:H11 str−. CVM10021
Escherichia coli O157:H7 str. EC4009
Escherichia coli O26:H11 str. CVM 10026
Escherichia coli O157:H7 str. EC4024
Escherichia coli O26:H11 str. CVM10030
Escherichia coli O157:H7 str. EC4042
Escherichia coli O26:H11 sir. CVM10224
Escherichia coli O157:H7 str. EC4045
Escherichia coli O26:H11 str. CVM9942
Escherichia coli O157:H7 str. EC4076
Escherichia coli O26:H11 str. CVM9952
Escherichia coli O157:H7 str. EC4084
Escherichia coli O26:H11:K60
Escherichia coli O157:H7 str. EC4113
Escherichia coli O26:NM
Escherichia coli O157:H7 str. EC4115
Escherichia coli O27
Escherichia coli O157:H7 str. EC4127
Escherichia coli O27 str. E47a
Escherichia coli O157:H7 str. EC4191
Escherichia coli O28ac:H−
Escherichia coli O157:H7 str. EC4192
Escherichia coli O29
Escherichia coli O1 57:H7 str. EC4196
Escherichia coli O29 str. Su4338-41
Escherichia coli O157:H7 str. EC4205
Escherichia coli O30
Escherichia coli O157.−H7 str. EC4206
Escherichia coli O30 str. P2a
Escherichia coli O157:H7 str. EC4401
Escherichia coli O32:H37
Escherichia coli O1 57:H7 str. EC4486
Escherichia coli O32:H37 str. P4
Escherichia coli O157:H7 str. EC4501
Escherichia coli O33
Escherichia coli O157:−H7 str. EC508
Escherichia coli O33 str. E40
Escherichia coli O157:H7 str. EC536
Escherichia coli O34
Escherichia coli O157:H7 str. EC869
Escherichia coli O34 str. H304
Escherichia coli O157:H7 str. EDL933
Escherichia coli O41:H−
Escherichia coli O157:H7 str. F8092B
Escherichia coli O42:H37
Escherichia coli O157:H7 str. FRIK2000
Escherichia coli O44:H 18
Escherichia coli O157:F£7 str. FRIK966
Escherichia coli O42
Escherichia coli O157:H7 str. G5101
Escherichia coli O45:H2
Escherichia coli O157:H7 str. GZ-021210/cattle
Escherichia coli O45:H2 str. 03-EN-705
Escherichia coli O157:117 str. II093800014
Escherichia coli O45:NM
Escherichia coli O157:H7 str. LSU-61
Escherichia coli O45:NM str. G4
Escherichia coii O5
Escherichia coli P0298942.7
Escherichia coli O5 str. TJ1-41
Escherichia coli P0298942.8
Escherichia coli O5:K4(L):H4 str. ATCC 23502
Escherichia coli P0298942.9
Escherichia coli O51:H−
Escherichia coli P0299438.10
Escherichia coli O55:H2
Escherichia coli P0299438.11
Escherichia coli O55:H51
Escherichia coli P0299438.2
Escherichia coli O55:TI6
Escherichia coli P0299438.3
Escherichia coli O55:H7
Escherichia coli P0299438.4
Escherichia coli O55:H7 str. 3256-97
Escherichia coli P0299438.5
Escherichia coli O55:H7 str. CB9615
Escherichia coli P0299438.6
Escherichia coli O55:H7 str. RM12579
Escherichia coli P0299438.7
Escherichia coli O55:H7 str. USDA 5905
Escherichia coli P0299438.8
Escherichia coli O5:H−
Escherichia coli P0299438.9
Escherichia coli O6
Escherichia coli P0299483.1
Escherichia coli O6 str. Bi7458-41
Escherichia coli P0299483.2
Escherichia coli O63:H6
Escherichia coli P0299483.3
Escherichia coli O63:HNM
Escherichia coli P02997067.6
Escherichia coli O6:HNM
Escherichia coli P0299917.1
Escherichia coli O70:NM
Escherichia coli P0299917.10
Escherichia coli O75:H2
Escherichia coli P0299917.2
Escherichia coli O78:H9
Escherichia coli P0299917.3
Escherichia coli IMT2125
Escherichia coli P0299917.4
Escherichia coli O7:K1
Escherichia coli P0299917.5
Escherichia coli O7:K1 str. CE10
Escherichia coli P0299917.6
Escherichia coli OS
Escherichia coli P02999I7.7
Escherichia coli O8 str. G3404-41
Escherichia coli P0299917.8
Escherichia coli O83:H1
Escherichia coli P0299917.9
Escherichia coli O83:H1 str. NRG 85 7C
Escherichia coli P0301867.1
Escherichia coli O84:H−
Escherichia coli P0301867.11
Escherichia coli O86a:H34
Escherichia coli P0301867.13
Escherichia coli O86a:H40
Escherichia coli P0301867.2
Escherichia coli O9
Escherichia coli P0301867.3
Escherichia coli O9 str. Bi316-42
Escherichia coli P0301867.4
Escherichia coli O90:H8
Escherichia coli P0301867.5
Escherichia coli O91
Escherichia coli P0301867.7
Escherichia coli O91 str. RM7190
Escherichia coli P0301867.8
Escherichia coli O91:H21
Escherichia coli P0301904.3
Escherichia coli O91:H21 str. B2F1
Escherichia coli P0302293.10
Escherichia coli O9:H51
Escherichia coli P0302293.2
Escherichia coli OK1114
Escherichia coli P0302293.3
Escherichia coli OK1180
Escherichia coli P0302293.4
Escherichia coli OK1357
Escherichia coli P0302293.6
Escherichia coli ONT:H−
Escherichia coli P0302293.7
Escherichia coli ONT:H10
Escherichia coli P0302293.8
Escherichia coli ONT:H25
Escherichia coli P0302293.9
Escherichia coli ONT:H33
Escherichia coli P0302308.1
Escherichia coli ONT:H33 str. C48/93
Escherichia coli P0302308.10
Escherichia coli OP50
Escherichia coli P0302308.11
Escherichia coli Orough:H12
Escherichia coli P0302308.12
Escherichia coli Orough:H19
Escherichia coli P0302308.13
Escherichia coli Orough:H34
Escherichia coli P0302308.14
Escherichia coli Orough:H37
Escherichia coli P0302308.2
Escherichia coli Orough:H9
Escherichia coli P0302308.3
Escherichia coli OUT:HI 2
Escherichia coli P0302308.4
Escherichia coli OUT:H18
Escherichia coli P0302308.5
Escherichia coli OUT:H45
Escherichia coli P0304777.1
Escherichia coli OUT:H6
Escherichia coli P0304777.10
Escherichia coli OUT:H7
Escherichia coli P0304777.1 1
Escherichia coli OUT:HNM
Escherichia coli P0304777.12
Escherichia coli OUT:NM
Escherichia coli P0304777.13
Escherichia coli P0298942.1
Escherichia coli P0304777.14
Escherichia coli P0298942.10
Escherichia coli P0304777.15
Escherichia coli P0298942.11
Escherichia coli P0304777.2
Escherichia coli P0298942.12
Escherichia coli P0304777.3
Escherichia coli P0298942.14
Escherichia coli P0304777.4
Escherichia coli P0298942.15
Escherichia coli P0304777.5
Escherichia coli P0298942.2
Escherichia coli P0304777.7
Escherichia coli P0298942.3
Escherichia coli P0304777.8
Escherichia coli P0298942.4
Escherichia coli P0304777.9
Escherichia coli P0298942.6
Escherichia coli P0304799.3
Escherichia coli P0304816.1
Escherichia coli PA49
Escherichia coli P0304816.10
Escherichia coli PA5
Escherichia coli P0304816.11
Escherichia coli PA7
Escherichia coli P0304816.12
Escherichia coli PA8
Escherichia coli P0304816.13
Escherichia coli PA9
Escherichia coli P0304816.14
Escherichia coli PB10
Escherichia coli P0304816.15
Escherichia coli PDA1
Escherichia coli P0304816.2
Escherichia coli PBA5
Escherichia coli P0304816.3
Escherichia coli PBA9
Escherichia coli P0304816.4
Escherichia coli PBB13
Escherichia coli P0304816.5
Escherichia coli PBB4
Escherichia coli P0304816.6
Escherichia coli PBB5
Escherichia coli P0304816.7
Escherichia coli PBB6
Escherichia coli P0304816.8
Escherichia coli PBC20
Escherichia coli P0304816.9
Escherichia coli PBC22
Escherichia coli P0305260.1
Escherichia coli PBC3
Escherichia coli P0305260.10
Escherichia coli PBC6
Escherichia coli P0305260.11
Escherichia coli PBC7
Escherichia coli P0305260.12
Escherichia coli PBD1
Escherichia coli P0305260.13
Escherichia coli PBD11
Escherichia coli P0305260.1 5
Escherichia coli PBD16
Escherichia coli P0305260.2
Escherichia coli PBD19
Escherichia coli P0305260.3
Escherichia coli PBD2
Escherichia coli P0305260.4
Escherichia coli PBD20
Escherichia coli P0305260.5
Escherichia coli PBD21
Escherichia coli P0305260.6
Escherichia coli PBD22
Escherichia coli P0305260.7
Escherichia coli PBD24
Escherichia coli P0305260.8
Escherichia coli PBD3
Escherichia coli P0305260.9
Escherichia coli PBD7
Escherichia coli p0305293.1
Escherichia coli PCN009
Escherichia coli p0305293.10
Escherichia coli PCN033
Escherichia coli p0305293.11
Escherichia coli PCN042
Escherichia coli p0305293.12
Escherichia coli PCN079
Escherichia coli p0305293.13
Escherichia coli PCN097
Escherichia coli p0305293.14
Escherichia coli PMV-1
Escherichia coli p0305293.15
Escherichia coli PS
Escherichia coli p0305293.2
Escherichia coli PUTI459
Escherichia coli p0305293.3
Escherichia coli R424
Escherichia coli p0305293.4
Escherichia coli R527
Escherichia coli p0305293.5
Escherichia coli R529
Escherichia coli p0305293.6
Escherichia coli RDEC-1 (10f)
Escherichia coli p0305293.7
Escherichia coli REL606
Escherichia coli p0305293.8
Escherichia coli RN587/1
Escherichia coli p0305293.9
Escherichia coli RS218
Escherichia coli PI2b
Escherichia coli S17
Escherichia coli P4-96
Escherichia coli S88
Escherichia coli P4-NR
Escherichia coli SCD1
Escherichia coli PA 10
Escherichia coli SCD2
Escherichia coli PA 14
Escherichia coli SCI-07
Escherichia coli PA 15
Escherichia coli SE11
Escherichia coli PA2
Escherichia coli SE15
Escherichia coli PA22
Escherichia coli SEPT362
Escherichia coli PA23
Escherichia coli SEQ895
Escherichia coli PA24
Escherichia coli SMS-3-5
Escherichia coli PA25
Escherichia coli STEC_7v
Escherichia coli PA28
Escherichia coli STEC_94C
Escherichia coli PA3
Escherichia coli STEC_B2F1
Escherichia coli PA31
Escherichia coli STEC_CI 65-02
Escherichia coli PA32
Escherichia coli STEC_DG131-3
Escherichia coli PA33
Escherichia coli STEC_EH250
Escherichia coli PA34
Escherichia coli STEC_H.1.8
Escherichia coli PA38
Escherichia coli STEC_MHI813
Escherichia coli PA39
Escherichia coli STEC_031
Escherichia coli PA4
Escherichia coli STEC_SI 191
Escherichia coli PA40
Escherichia coli STHG79
Escherichia coli PA41
Escherichia coli str. ‘clone D il4’
Escherichia coli PA42
Escherichia coli str. ‘clone D i2’
Escherichia coli PA45
Escherichia coli str. Deng
Escherichia coli PA47
Escherichia coli SWW33
Escherichia coli PA48
Escherichia coli T1282_01
Escherichia coli T1840 97
Escherichia coli TW10491
Escherichia coli T234_00
Escherichia coli TW10503
Escherichia coli T408
Escherichia coli TW10509
Escherichia coli T426
Escherichia coli TW10512
Escherichia coli T924 01
Escherichia coli TW10518
Escherichia coli TA004
Escherichia coli TW10519
Escherichia coli TA007
Escherichia coli TW10523
Escherichia coli TA008
Escherichia coli TW10526
Escherichia coli TA014
Escherichia coli TW10530
Escherichia coli TA024
Escherichia coli TW10537
Escherichia coli TA054
Escherichia coli TW10545
Escherichia coli TA103
Escherichia coli TW 10547
Escherichia coli TA124
Escherichia coli TW10564
Escherichia coli TA141
Escherichia coli TW10568
Escherichia coli TA143
Escherichia coli TW 10595
Escherichia coli TA144
Escherichia coli TW10598
Escherichia coli TA155
Escherichia coli TW10619
Escherichia coli TA206
Escherichia coli TW10664
Escherichia coli TA249
Escherichia coli TW10722
Escherichia coli TA255
Escherichia coli TW10738
Escherichia coli TA271
Escherichia coli TW10742
Escherichia coli TA280
Escherichia coli TW10747
Escherichia coli TA435
Escherichia coli TW10785
Escherichia coli TA445
Escherichia coli TW10818
Escherichia coli TA447
Escherichia coli TW10828
Escherichia coli TA464
Escherichia coli TW10880
Escherichia coli ThroopD
Escherichia coli TW10894
Escherichia coli TOP2386
Escherichia coli TW10899
Escherichia coli TOP2396-1
Escherichia coli TW11039
Escherichia coli TOP2396-2
Escherichia coli TW11606
Escherichia coli TOP2396-3
Escherichia coli TW11638
Escherichia coli TOP2515
Escherichia coli TW11651
Escherichia coli TOP2522-1
Escherichia coli TW11666
Escherichia coli TOP2522-3
Escherichia coli TW11681
Escherichia coli TOP2652
Escherichia coli TW11685
Escherichia coli TOP2662-1
Escherichia coli TW11690
Escherichia coli TOP2662-2
Escherichia coli KTE230
Escherichia coli TOP2662-3
Escherichia coli KTE231
Escherichia coli TOP2662-4
Escherichia coli KTE232
Escherichia coli TOP291
Escherichia coli KTE233
Escherichia coli TOP293-1
Escherichia coli KTE234
Escherichia coli TOP293-2
Escherichia coli KTE235
Escherichia coli TOP293-3
Escherichia coli KTE236
Escherichia coli TOP293-4
Escherichia coli KTE237
Escherichia coli TOP379
Escherichia coli KTE24
Escherichia coli TOP382-1
Escherichia coli KTE240
Escherichia coli TOP382-2
Escherichia coli KTE25
Escherichia coli TOP382-3
Escherichia coli KTE26
Escherichia coli TOP498
Escherichia coli KTE27
Escherichia coli TOP550-1
Escherichia coli KTE28
Escherichia coli TOP550-2
Escherichia coli KTE29
Escherichia coli TOP550-3
Escherichia coli KTE3
Escherichia coli TOP550-4
Escherichia coli KTE31
Escherichia coli TT12B
Escherichia coli KTE33
Escherichia coli TW00353
Escherichia coli KTE34
Escherichia coli TW06591
Escherichia coli KTE35
Escherichia coli TW07509
Escherichia coli KTE36
Escherichia coli TW07793
Escherichia coli KTE37
Escherichia coli TW07945
Escherichia coli KTE38
Escherichia coli TW09098
Escherichia coli KTE39
Escherichia coli TW09109
Escherichia coli KTE4
Escherichia coli TW09195
Escherichia coli KTE40
Escherichia coli TW10119
Escherichia coli KTE41
Escherichia coli TW10245
Escherichia coli KTE42
Escherichia coli TW10246
Escherichia coli KTE43
Escherichia coli TW10470
Escherichia coli KTE44
Escherichia coli TW10481
Escherichia coli KTE45
Escherichia coli TW10483
Escherichia coli KTE46
Escherichia coli TW10484
Escherichia coli KTE47
Escherichia coli TW10485
Escherichia coli KTE48
Escherichia coli HS
Escherichia coli LT-62
Escherichia coli HT115
Escherichia coli LT-68
Escherichia coli HUSEC2001
Escherichia coli LY180
Escherichia coli HUSEO2011
Escherichia coli M056
Escherichia coli KTE52
Escherichia coli M1
Escherichia coli KTE53
Escherichia coli M10
Escherichia coli KTE54
Escherichia coli M11
Escherichia coli KTE55
Escherichia coli M114
Escherichia coli KTE56
Escherichia coli M12
Escherichia coli KTES7
Escherichia coli M13
Escherichia coli KTES8
Escherichia coli M14
Escherichia coli KTE59
Escherichia coli Ml5
Escherichia coli KTE6
Escherichia coli M16
Escherichia coli KTE60
Escherichia coli M17
Escherichia coli KTE61
Escherichia coli Ml8
Escherichia coli KTE62
Escherichia coli M19
Escherichia coli KTE63
Escherichia coli M2
Escherichia coli KTE64
Escherichia coli M20
Escherichia coli KTE65
Escherichia coli M21
Escherichia coli KTE66
Escherichia coli M22
Escherichia coli KTE67
Escherichia coli M23
Escherichia coli KTE68
Escherichia coli M3
Escherichia coli KTE69
Escherichia coli M4
Escherichia coli KTE7
Escherichia coli M5
Escherichia coli KTE70
Escherichia coli M6
Escherichia coli KTE71
Escherichia coli M605
Escherichia coli KTE72
Escherichia coli M646
Escherichia coli KTE73
Escherichia coli M7
Escherichia coli KTE74
Escherichia coli M718
Escherichia coli KTE75
Escherichia coli M8
Escherichia coli KTE76
Escherichia coli M863
Escherichia coli KTE77
Escherichia coli M9
Escherichia coli KTE78
Escherichia coli M919
Escherichia coli KTE79
Escherichia coli UMEA 3687-1
Escherichia coli KTE8
Escherichia coli UMEA 3693-1
Escherichia coli KTE80
Escherichia coli UMEA 3694-1
Escherichia coli KTE81
Escherichia coli UMEA 3702-1
Escherichia coli KTE82
Escherichia coli UMEA 3703-1
Escherichia coli KTE83
Escherichia coli UMEA 3705-1
Escherichia coli KTE84
Escherichia coli UMEA 3707-1
Escherichia coli KTE85
Escherichia coli UMEA 3718-1
Escherichia coli KTE86
Escherichia coli UMEA 3805-1
Escherichia coli KTE87
Escherichia coli UMEA 3821-1
Escherichia coli KTE88
Escherichia coli UMEA 3834-1
Escherichia coli KTE89
Escherichia coli UMEA 3889-1
Escherichia coli KTE9
Escherichia coli UMEA 3893-1
Escherichia coli KTE90
Escherichia coli UMEA 3899-1
Escherichia coli KTE91
Escherichia coli UMEA 3955-1
Escherichia coli KTE93
Escherichia coli UMEA 4075-1
Escherichia coli KTE94
Escherichia coli CTMEA 4076-1
Escherichia coli KTE95
Escherichia coli UMEA 4207-1
Escherichia coli KTE96
Escherichia coli UMN026
Escherichia coli KTE97
Escherichia coli UMNF18
Escherichia coli KTE98
Escherichia coli LTMNK88
Escherichia coli KTE99
Escherichia coli UTI89
Escherichia coli LAU-EC1
Escherichia coli VDP
Escherichia coli LAU-EC10
Escherichia coli Vir68
Escherichia coli EALI-EC2
Escherichia coli VI.2732
Escherichia coli LAU-EC3
Escherichia coli VI.2874
Escherichia coli LAU-EC4
Escherichia coli VR50
Escherichia coli LAU-EC5
Escherichia coli W
Escherichia coli LAU-EC6
Escherichia coli W113
Escherichia coli LAU-EC 7
Escherichia coli W181
Escherichia coli LAU-EC8
Escherichia coli W202
Escherichia coli LAU-EC9
Escherichia coli W26
Escherichia coli LCT-EC106
Escherichia coli Wa1
Escherichia coli LCT-EC52
Escherichia coli Wa2
Escherichia coli LCT-EC59
Escherichia coli WC1
Escherichia coli LF82
Escherichia coli WC2
Escherichia coli LT-41
Escherichia coli WV_060327
Escherichia coli XH001
Escherichia coli UMEA 3155-1
Escherichia coli XH140A
Escherichia coli UMEA 3159-1
Escherichia coli Xuzhou21
Escherichia coli UMEA 3160-1
Escherichia coli TW11694
Escherichia coli UMEA 3161-1
Escherichia coli TW11699
Escherichia coli UMEA 3162-1
Escherichia coli TW11704
Escherichia coli UMEA 3 163-1
Escherichia coli TW11728
Escherichia coli UMEA 3172-1
Escherichia coli TW11737
Escherichia coli UMEA 3173-1
Escherichia coli TW11741
Escherichia coli UMEA 3174-1
Escherichia coli TW11756
Escherichia coli UMEA 3 175-1
Escherichia coli TW11767
Escherichia coli UMEA 3176-1
Escherichia coli TW11786
Escherichia coli UMEA 3178-1
Escherichia coli TW11816
Escherichia coli UMEA 3180-1
Escherichia coli TW11833
Escherichia coli UMEA 3185-1
Escherichia coli TW11839
Escherichia coli UMEA 3190-1
Escherichia coli TW11890
Escherichia coli UMEA 3193-1
Escherichia coli TW11906
Escherichia coli UMEA 3199-1
Escherichia coli TW11917
Escherichia coli UMEA 3200-1
Escherichia coli TW11950
Escherichia coli UMEA 3201-1
Escherichia coli TW11951
Escherichia coli UMEA 3203-1
Escherichia coli TW11973
Escherichia coli UMEA 3206-1
Escherichia coli TW 12001
Escherichia coli UMEA 3208-1
Escherichia coli TW12002
Escherichia coli UMEA 3212-1
Escherichia coli TW 12009
Escherichia coli UMEA 3215-1
Escherichia coli TW12014
Escherichia coli UMEA 3216-1
Escherichia coli TW12019
Escherichia coli UMEA 3217-1
Escherichia coli TW12023
Escherichia coli UMEA 3220-1
Escherichia coli TW12033
Escherichia coli UMEA 3221-1
Escherichia coli TW12082
Escherichia coli UMEA 3222-1
Escherichia coli TW12086
Escherichia coli UMEA 3230-1
Escherichia coli TW12093
Escherichia coli UMEA 3233-1
Escherichia coli TW12101
Escherichia coli UMEA 3240-1
Escherichia coli TW14301
Escherichia coli UMEA 3244-1
Escherichia coli TW14313
Escherichia coli UMEA 3252-1
Escherichia coli TW14380
Escherichia coli UMEA 3257-1
Escherichia coli TW14390
Escherichia coli UMEA 3264-1
Escherichia coli TW14397
Escherichia coli UMEA 3268-1
Escherichia coli KTE49
Escherichia coli UMEA 3271-1
Escherichia coli KTE5
Escherichia coli UMEA 3290-1
Escherichia coli KTE50
Escherichia coli UMEA 3292-1
Escherichia coli KTE51
Escherichia coli UMEA 3298-1
Escherichia coli TW14711
Escherichia coli UMEA 3304-1
Escherichia coli TW15901
Escherichia coli UMEA 3314-1
Escherichia coli Txl686
Escherichia coli UMEA 3317-1
Escherichia coli TX1999
Escherichia coli UMEA 3318-1
Escherichia coli Tx3800
Escherichia coli UMEA 3323-1
Escherichia coli UM146
Escherichia coli UMEA 3329-1
Escherichia coli UMEA 3014-1
Escherichia coli UMEA 3336-1
Escherichia coli UMEA 3022-1
Escherichia coli UMEA 3337-1
Escherichia coli EIMEA 3033-1
Escherichia coli UMEA 3341-1
Escherichia coli UMEA 3041-1
Escherichia coli UMEA 3342-1
Escherichia coli UMEA 3052-1
Escherichia coli UMEA 3355-1
Escherichia coli UMEA 3053-1
Escherichia coli LTMEA 3391-1
Escherichia coli UMEA 3065-1
Escherichia coli UMEA 3426-1
Escherichia coli UMEA 3087-1
Escherichia coli UMEA 3489-1
Escherichia coli UMEA 3088-1
Escherichia coli UMEA 3490-1
Escherichia coli UMEA 3097-1
Escherichia coli LTMEA 3585-1
Escherichia coli UMEA 3108-1
Escherichia coli UMEA 3592-1
Escherichia coli UMEA 3113-1
Escherichia coli UMEA 3609-1
Escherichia coli UMEA 3117-1
Escherichia coli UMEA 3617-1
Escherichia coli UMEA 3121-1
Escherichia coli UMEA 3632-1
Escherichia coli UMEA 3122-1
Escherichia coli UMEA 3652-1
Escherichia coli UMEA 3124-1
Escherichia coli UMEA 3656-1
Escherichia coli UMEA 3139-1
Escherichia coli UMEA 3662-1
Escherichia coli UMEA 3140-1
Escherichia coli UMEA 3671-1
Escherichia coli UMEA 3144-1
Escherichia coli UMEA 3682-1
Escherichia coli UMEA 3148-1
Escherichia coli TW14435
Escherichia coli UMEA 3150-1
Escherichia coli TW14406
Escherichia coli UMEA 3151-1
Escherichia coli TW14425
Escherichia coli UMEA 3152-1
Escherichia coli TW14427
Escherichia faecaiis
Escherichia sp. ASG34
Escherichia fergusonii
Escherichia sp. B1147
Escherichia fergusonii ATCC 35469
Escherichia sp. B1225
Escherichia fergusonii B253
Escherichia sp. B4
Escherichia fergusonii ECD227
Escherichia sp. B49
Escherichia hermannii
Escherichia sp. B646
Escherichia hermannii NDRC 105704
Escherichia sp. B685
Escherichia senegalensis
Escherichia sp. B827
Escherichia vulneris
Escherichia sp. BBDP20
Escherichia vulneris NBRC 102420
Escherichia sp. BBDP27
Escherichia sp. 003.10
Escherichia sp. BV24
Escherichia sp. 003.14
Escherichia sp. BV25
Escherichia sp. 003.22
Escherichia sp. CO13(2010)
Escherichia sp. 003.23
Escherichia sp. CPD32
Escherichia sp. 006.16
Escherichia sp. daliu
Escherichia sp. 006.18
Escherichia sp. dayi
Escherichia sp. 006.33
Escherichia sp. DGM MC1E
Escherichia sp. 1.1-11
Escherichia sp. DGM MC3E
Escherichia sp. 1.3-02
Escherichia sp. DGM MC4E
Escherichia sp. 1.9-16
Escherichia sp. DJM1A6
Escherichia sp. 104.10
Escherichia sp. DJM1A8
Escherichia sp. 105.12
Escherichia sp. DJM1B4
Escherichia sp. 105.16
Escherichia sp. DJM1B6
Escherichia sp. 105.17
Escherichia sp. DJM1C4
Escherichia sp. 105.3
Escherichia sp. DM104
Escherichia sp. 105.30
Escherichia sp. DSD31
Escherichia sp. 105.6
Escherichia sp. DSP
Escherichia sp. 115
Escherichia sp. E1118
Escherichia sp. 12
Escherichia sp. E195
Escherichia sp. 1_1_43
Escherichia sp. E1196
Escherichia sp. 2.2.5-13
Escherichia sp. E1492
Escherichia sp. 21CR
Escherichia sp. E24-PCAi-T2P21
Escherichia sp. 22
Escherichia sp. E25-PCAi-T2P21
Escherichia sp. 23
Escherichia sp. E471
Escherichia sp. 23CR
Escherichia sp. E472
Escherichia sp. 253b
Escherichia sp. E5-PCAi-T2P21
Escherichia sp. 26N
Escherichia sp. E620
Escherichia sp. 28N
Escherichia sp. E7-PCAi-T2P21
Escherichia sp. 3-26(2010)
Escherichia sp. E807
Escherichia sp. 32
Escherichia sp. EC3
Escherichia sp. 33
Escherichia sp. EECC-575
Escherichia sp. 34
Escherichia sp. EECC-590
Escherichia sp. 3_2_53FAA
Escherichia sp. EMB 210
Escherichia sp. 4
Escherichia sp. EMB 339
Escherichia sp. 4067
Escherichia sp. ES13
Escherichia sp. 4094
Escherichia sp. F24-PCAi-T3P21
Escherichia sp. 41
Escherichia sp. FH12
Escherichia sp. 42
Escherichia sp. FH14
Escherichia sp. 43
Escherichia sp. FHM101
Escherichia sp. 49
Escherichia sp. FHM102
Escherichia sp. 49A
Escherichia sp. FHM106
Escherichia sp. 4_1_40B
Escherichia sp. FHM113
Escherichia sp. 4B
Escherichia sp. G3
Escherichia sp. 54
Escherichia sp. GDR06
Escherichia sp. 63
Escherichia sp. H442
Escherichia sp. 64
Escherichia sp. H605
Escherichia sp. 68
Escherichia sp. HPCKc-45
Escherichia sp. 6B
Escherichia sp. 16
Escherichia sp. 6CR
Escherichia sp. IICFP6
Escherichia sp. 75R
Escherichiasp. II_B13
Escherichia sp. 7CR
Escherichia sp. July_KB 1F3
Escherichia sp. 80
Escherichia sp. July_NA2A8
Escherichia sp. 88
Escherichia sp. July_TSA2A8
Escherichia sp. A422
Escherichia sp. Kaveri_River_12
Escherichia sp. A441
Escherichia sp. M1108
Escherichia sp. A741
Escherichia sp. M1N2G03
Escherichia sp. A94
Escherichia sp. M2T9B5
Escherichia sp. AF4
Escherichia sp. M863
Escherichia sp. AI(2010)
Escherichia sp. ML-11
Escherichia sp. AJ(2010)
Escherichia sp. ML2-46
Escherichia sp. MSCB-10
Escherichia sp. ZHS050713
Escherichia sp. NBRC 13921
Escherichia sp. ZHS050714
Escherichia sp. Nil
Escherichia sp. ZY-2006a
Escherichia sp. Nj-91
Escherichia sp. 4
Escherichia sp. NMU-ST2
Escherichia sp. OES18
Escherichia coli CAG:4
Escherichia sp. P14
Escherichia sp. enrichment culture clone 01-084
Escherichia sp. PF7
Escherichia sp. enrichment culture clone 02-023
Escherichia sp. RL325/96
Escherichia sp. enrichment culture clone 03-018
Escherichia sp. S4-AA1-4
Escherichia sp. enrichment culture clone 03-426
Escherichia sp. Sam130-5B
Escherichia sp. enrichment culture clone 04
Escherichia sp. Sam130-6A
Escherichia sp. enrichment culture clone 1(2012)
Escherichia sp. SC-C4-4
Escherichia sp. enrichment culture clone 11(2012)
Escherichia sp. SDT20
Escherichia sp. enrichment culture clone 12
Escherichia sp. Sflu5
Escherichia sp. enrichment culture clone 16
Escherichia sp. SI-56
Escherichia sp. enrichment culture clone 17
Escherichia sp. SO-A5-32
Escherichia sp. enrichment culture clone 19(2012)
Escherichia sp. SO-Y1-39
Escherichia sp. enrichment culture clone 23
Escherichia sp. SOD-7317
Escherichia sp. enrichment culture clone 3(2012)
Escherichia sp. Souza-207
Escherichia sp. enrichment culture clone 9(2012)
Escherichia sp. Souza-273
Escherichia sp. enrichment culture clone AVCTGRB2A
Escherichia sp. Souza-57
Escherichia sp. enrichment culture clone AVCTGRB2B
Escherichia sp. SR2-18-f
Escherichia sp. enrichment culture clone CMX
Escherichia sp. SVUB6
Escherichia sp. enrichment culture clone Jdgsrb051
Escherichia sp. SW86
Escherichia sp. enrichment culture clone Jdgsrb055
Escherichia sp. SWM Isolation 4
Escherichia sp. enrichment culture clone Jdgsrb056
Escherichia sp. SZ-6
Escherichia sp. enrichment culture clone NBAR001
Escherichia sp. T2
Escherichia sp. enrichment culture clone NBAR004
Escherichia sp. TA04
Escherichia sp. enrichment culture clone NBAR005
Escherichia sp. TA290
Escherichia sp. enrichment culture clone NBAR006
Escherichia sp. TW09231
Escherichia sp. enrichment culture clone NBAR013
Escherichia sp. TW09254
Escherichia sp. enrichment culture clone NBAR015
Escherichia sp. TW09266
Escherichia sp. enrichment culture clone NBAR018
Escherichia sp. TW09276
Escherichia sp. enrichment culture clone NBAR020
Escherichia sp. TW09308
Escherichia sp. enrichment culture clone NBAR022
Escherichia sp. TW10509
Escherichia sp. enrichment culture clone NBAR023
Escherichia sp. TW11930
Escherichia sp. enrichment culture clone NBAR024
Escherichia sp. TW11966
Escherichia sp. enrichment culture clone NX
Escherichia sp. TW14182
Escherichia sp. enrichment culture clone R_1017-3_OTU3
Escherichia sp. TW 14263
Escherichia sp. enrichment culture clone R_8m3_OTU3
Escherichia sp. TW 14264
Escherichia sp. enrichment culture clone SRC_NBA4
Escherichia sp. TW 14265
Escherichia sp. enrichment culture clone SRC_NBA7
Escherichia sp. TW 14266
Escherichia sp. enrichment culture clone SRC_NBA8
Escherichia sp. TW 14267
Escherichia sp. enrichment culture clone SunHY
Escherichia sp. TW15838
Escherichia sp. enrichment culture clone V-S5SRC 1-51
Escherichia sp. TX3
Escherichia sp. enrichment culture DGGE band D5
Escherichia sp. V2M20
Escherichia sp. oral clone 3RH-30
Escherichia sp. V3M66
Escherichia sp. VA17
Escherichia sp. VF2(2010)
Escherichia sp. W8-PCAi-E14
Escherichia sp. Z205
Cardinium endosymbiont of Culicoides iungchiensis
Cardinium endosymbiont of Culicoides ohmorii
Cardinium endosymbiont of Culicoides peregrinus
Cardinium endosymbiont of Cybaeota nana
Cardinium endosymbiont of Cybaeus chauliodous
Cardinium endosymbiont of Cybaeus chaulodious
Cardinium endosymbiont of Cybaeus eutypus
Cardinium endosymbiont of Cybaeus hesper
Cardinium endosymbiont of Cybaeus morosus
Cardinium endosymbiont of Cybaeus multnoma
Cardinium endosymbiont of Cybaeus paralypropriapus
Cardinium endosymbiont of Cybaeus penedenlatus
Cardinium endosymbiont of Cybaeus reticulatus
Cardinium endosymbiont of Cybaeus sanbruno
Cardinium endosymbiont of Cybaeus signifcr
Cardinium endosymbiont of Cybaeus somesbar
Cardinium endosymbiont of Cybaeus waynei
Cardinium endosymbiont of Dermanyssus gallinae
Cardinium endosymbiont of Encarsia hispida
Cardinium endosymbiont of Encarsia inaron
Cardinium endosymbiont of Encarsia pergandiella
Cardinium endosymbiont of Eotetranychus suginamensis
Cardinium endosymbiont of Euidcs speciosa
Caidinium endosymbiont of Formica cinerea
Cardinium endosymbiont of Harmalia sirokata
Cardinium endosymbiont of Hemiberiesia paimae
Cardinium endosymbiont of Holocnemus pluchei
Caidinium endosymbiont of honey bee mite
Cardinium endosymbiont of Howardia biclavis
Cardinium endosymbiont of Indozuriel dantur
Cardinium endosymbiont of Ixodes scapularis
Cardinium endosymbiont of Leiobunum vittatum
Cardinium endosymbiont of Lepidosaphes pinnaeformis
Cardinium endosymbiont of Leucaspis pusilla
Cardinium endosymbiont of Nitocra spinipes
Cardinium endosymbiont of Oceanaspidiotus spinosus
Cardinium endosymbiont of Oedothorax gibbosus
Cardinium endosymbiont of Oedothorax retusus
Cardinium endosymbiont of Oligonychus ilicis
Cardinium endosymbiont of Palinaspis quohogiformis
Cardinium endosymbiont of Pallulaspis ephedrae
Cardinium endosymbiont of Panonychus ulmi
Cardinium endosymbiont of Petrobia harti
Cardinium endosymbiont of Phalangium opilio
Sunxiuqinia
Cardinium endosymbiont of Plagiomerus diaspidis
Sunxiuqinia elliptica
Cardinium endosymbiont of Poliaspis media
Sunxiuqinia sp. CAU1234
Cardinium endosymbiont of Protargionia larreae
Sunxiuqinia sp. JNU-J035
Cardinium endosymbiont of Rilacna triangularis
Sunxiuqinia sp. JNU-SGY008
Cardinium endosymbiont of Scaphoideus titanus
Sunxiuqinia sp. SCSIO N0430
Cardinium endosymbiont of Sogatella furcifera
Cardinium endosymbiont of Tetranychus cinnabarinus
Bifissio
Cardinium endosymbiont of Tetranychus pucraricola
Bifissio spartinae
Cardinium endosymbiont of Tetranychus urticae
Cardinium endosymbiont of Tetranychus urticae red form A
Candidatus Amoebophilus
Cardinium endosymbiont of Tetranychus urticae red form B
Candidatus Amoebophilus asiaticus
Cardinium endosymbiont of Tetranychus urticae red form C
Cardinium endosymbiont of Unaspis euonymi
Cardinium symbiont of Neoseiulus paspalivorus
Candidatus Cardinium
Candidatus Cardinium sp. Sigean4
Candidatus Cardinium hertigii
Cardinium endosymbiont of Anyphaenidae sp.
Cardinium endosymbiont of Abgrallaspis degenerata
Cardinium endosymbiont of Aonidomytilus sp.
Cardinium endosymbiont of Aleurodicus dispersus
Cardinium endosymbiont of Aphytis sp.
Cardinium endosymbiont of Amphitetranychus quercivorus
Cardinium endosymbiont of Araneidae sp.
Cardinium endosymbiont of Aspediotus paranerii
Cardinium endosymbiont of Brevipalpus sp.
Cardinium endosymbiont of Aspidiotus nerii
Cardinium endosymbiont of Chaetodactylus sp.
Cardinium endosymbiont of Bemisia tabaci
Cardinium endosymbiont of Leiobunum sp.
Cardinium endosymbiont of Bryobia rubrioculus
Cardinium endosymbiont of Marietta sp.
Cardinium endosymbiont of Bryobia sarothamni
Cardinium endosymbiont of Melanaspis sp.
Cardinium endosymbiont of Chionaspis heterophyllae
Cardinium endosymbiont of Prodigiaspis sp.
Cardinium endosymbiont of Culicoides arakawae
Cardinium endosymbiont of Pseudoparlatoria sp.
Cardinium endosymbiont of Rilaena sp.
Cardinium endosymbiont of Salticidae sp.
Cardinium endosymbiont of Tetragnathidae sp.
Cardinium endosymbiont of Theridiidae sp.
Candidatus Paenicardinium
Candidatus Paenicardinium endonii
Marinifilum
Marinifilum fragile
Marinifilum sp. CECT 7448
Marinifilum sp. JNU-H032
Marinifilum sp. JNU-H036
Marinifilum sp. JNU-J034
Marinifilum sp. KYW 585
Prolixibacter
Prolixibacter bellariivorans
Tuber borcliii symbiont b-lORA
Tuber borchii symbiont b-1 7BO
Tuber borchii symbiont b-1 BO
Tuber borchii symbiont b-Z43
Venteria
Venteria marina
Coleomegilla maculata male-killing endosymbiont
Encarsia berlesei endosymbiont
Encarsia citrina endosymbiont
Encarsia hispida endosymbiont
Encarsia pergandiella asexual line endosymbiont
Encarsia pergandiella sexual line endosymbiont
Eubostrichus dianae epibacterium 1 60
Robbea sp. associated bacterium 4
Stilbonema sp. associated bacterium 2
Stilbonema sp. associated bacterium 3
Stilbonema sp. associated bacterium 4
Stilbonema sp. associated bacterium 5
Stilbonema sp. associated baclerium 6
Stilbonema sp. associated bacterium 7
Rhodothermus
Rubricoecus
Salinibacter
Salisaeta
Thermonema
Thermonema lapsum
Thermonema rossianum
Flexibacter maritimus-like bacterium S3C18
Flexibacter maritimus-like bacterium S3C19
Flexibacter maritimus-like bacterium S3C20
Lactobacillus acetotolerans
Lactobacillus coleohominis
Lactobacillus acetotolerans JCM 3825
Lactobacillus coleohominis 101-4-CHN
Lactobacillus acidifarinae
Lactobacillus coleohominis DSM 14060
Lactobacillus acidipiscis
Lactobacillus collinoides
Lactobacillus acidipiscis KCTC 13900
Lactobacillus composti
Lactobacillus acidophilus
Lactobacillus concavus
Lactobacillus acidophilus 30SC
Lactobacillus coryniformis
Lactobacillus acidophilus ATCC 4796
Lactobacillus coryniformis subsp. coryniformis
Lactobacillus acidophilus CIP 76.13
Lactobacillus coryniformis subsp. coiyniformis CECT 5711
Lactobacillus acidophilus CIRM-BIA 442
Lactobacillus coryniformis subsp. coiyniformis KCTC 3167
Lactobacillus acidophilus CIRM-BIA 445
Lactobacillus coryniformis subsp. torquens
Lactobacillus acidophilus CRBIP 24179
Lactobacillus coryniformis subsp. torquens KCTC 3535
Lactobacillus acidophilus DSM 20242
Lactobacillus crispatus
Lactobacillus acidophilus DSM 9126
Lactobacillus crispatus 125-2-CHN
Lactobacillus acidophilus JV3179
Lactobacillus crispatus 2029
Lactobacillus acidophilus La-14
Lactobacillus crispatus 214-1
Lactobacillus acidophilus NCFM
Lactobacillus crispatus CTV-05
Lactobacillus agilis
Lactobacillus crispatus EX533959VC01
Lactobacillus algidus
Lactobacillus crispatus EX533959VC03
Lactobacillus alimentarius
Lactobacillus crispatus EX533959VC04
Lactobacillus alvei
Lactobacillus crispatus EX533959VC05
Lactobacillus alvi
Lactobacillus crispatus EX533959VC06
Lactobacillus amylolyticus
Lactobacillus crispatus EX533959VC07
Lactobacillus amylolyticus DSM 11664
Lactobacillus crispatus EX533959VC13
Lactobacillus amylophilus
Lactobacillus crispatus EX849587VC01
Lactobacillus amylophilus JCM 1125
Lactobacillus crispatus EX849587VC02
Lactobacillus amylotrophicus
Lactobacillus crispatus EX849587VC04
Lactobacillus amylovorus
Lactobacillus crispatus EX849587VC07
Lactobacillus amylovorus DSM 16698
Lactobacillus crispatus EX849587VC08
Lactobacillus amylovorus GRI. 1112
Lactobacillus crispatus FB049-03
Lactobacillus amylovoms GRL 1115
Lactobacillus crispatus FB077-07
Lactobacillus amylovoms GRL1118
Lactobacillus crispatus JCM 1185
Lactobacillus animalis
Lactobacillus crispatus JV-V01
Lactobacillus animalis KCTC 3501
Lactobacillus crispatus MV-lA-tJS
Lactobacillus animata
Lactobacillus crispatus MV-3A-FTS
Lactobacillus antri
Lactobacillus crispatus SJ-3C-US
Lactobacillus antri DSM 16041
Lactobacillus crispatus ST1
Lactobacillus apis
Lactobacillus crustorum
Lactobacillus apodemi
Lactobacillus crustorum FH4
Lactobacillus aquaticus
Lactobacillus curvatus
Lactobacillus aviarius
Lactobacillus curvatus CRL 705
Lactobacillus aviarius subsp. araffinosus
Lactobacillus curvatus F16 9
Lactobacillus aviarius subsp. aviarius
Lactobacillus curvatus JCM 1096
Lactobacillus backi
Lactobacillus curvatus WSU1
Lactobacillus bifermentans
Lactobacillus brevisimilis
Lactobacillus brantae
Lactobacillus buchneri
Lactobacillus brevis
Lactobacillus buchneri ATCC 11577
Lactobacillus brevis AG48
Lactobacillus buchneri CD034
Lactobacillus brevis ATCC 14869
Lactobacillus buchneri NRRL B-30929
Lactobacillus brevis ATCC 367
Lactobacillus cacaonum
Lactobacillus brevis KB290
Lactobacillus camelliae
Lactobacillus brevis subsp. gravesensis
Lactobacillus capillatus
Lactobacillus brevis subsp. gravesensis ATCC 27305
Lactobacillus casei group
Lactobacillus casei
Lactobacillus delbrueckii subsp. bulgaricus 2038
Lactobacillus casei 12A
Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842
Lactobacillus casei 21/1
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
Lactobacillus casei 32G
Lactobacillus delbrueckii subsp. bulgaricus CNCM 1-1519
Lactobacillus casei A2-362
Lactobacillus delbrueckii subsp. bulgaricus CNCM 1-1632
Lactobacillus casei ATCC 334
Lactobacillus delbrueckii subsp. bulgaricus ND02
Lactobacillus casei DD-II
Lactobacillus delbrueckii subsp. bulgaricus PB2003/044-T3-4
Lactobacillus casei BL23
Lactobacillus delbrueckii subsp. delbrueckii
Lactobacillus casei CRF28
Lactobacillus delbrueckii subsp. indicus
Lactobacillus casei DN-114001
Lactobacillus delbrueckii subsp. lactis
Lactobacillus casei Lc-10
Lactobacillus delbrueckii subsp. lactis CRL581
Lactobacillus casei LC2W
Lactobacillus delbrueckii subsp. lactis DSM 20072
Lactobacillus casei LcA
Lactobacillus delbrueckii subsp. sunkii
Lactobacillus casei LcY
Lactobacillus delbrueckii ZN7a-9
Lactobacillus casei LOCK919
Lactobacillus dcxtrinicus
Lactobacillus casei Lpc-37
Lactobacillus diolivorans
Lactobacillus casei M36
Lactobacillus equi
Lactobacillus casei str. Zhang
Lactobacillus equicursoris
Lactobacillus casei subsp. casei ATCC 393
Lactobacillus equicursoris CIP 110162
Lactobacillus casei T71499
Lactobacillus equigenerosi
Lactobacillus casei UCD174
Lactobacillus fabifermentans
Lactobacillus casei UW1
Lactobacillus faeni
Lactobacillus casei UW4
Lactobacillus farciminis
Lactobacillus casei W56
Lactobacillus farciminis KCTC 3681
Lactobacillus paracasei
Lactobacillus farraginis
Lactobacillus paracasei COM0101
Lactobacillus fermentum
Lactobacillus paracasei subsp. paracasei
Lactobacillus fermentum 28-3-CHN
Lactobacillus paracasei subsp. tolerans
Lactobacillus fermentum 3872
Lactobacillus paracasei TXW
Lactobacillus fermentum ATCC 14931
Lactobacillus zeae
Lactobacillus fermentum CECT 5716
Lactobacillus zeae KCTC 3804
Lactobacillus fermentum F-6
Lactobacillus sp. LA601
Lactobacillus fermentum FTDC8312
Lactobacillus sp. Od.76
Lactobacillus fermentum IFO 3956
Lactobacillus catenefornis
Lactobacillus fermentum Lfl
Lactobacillus catenefornis DSM 20559
Lactobacillus fermentum MTCC 8711
Lactobacillus ceti
Lactobacillus floricola
Lactobacillus ceti DSM 22408
Lactobacillus riorum
Lactobacillus fuchuensis
Lactobacillus florum 2F
Lactobacillus futsaii
Lactobacillus florum 8D
Lactobacillus gallinarum
Lactobacillus fornicalis
Lactobacillus gasseri
Lactobacillus fructivorans
Lactobacillus gasseri 2016
Lactobacillus fructivorans KCTC 3543
Lactobacillus gasseri 202-4
Lactobacillus frumenti
Lactobacillus gasseri 224-1
Lactobacillus mali
Lactobacillus gasseri ADL-35 1
Lactobacillus mali KCTC 3596 = DSM 20444
Lactobacillus gasseri ATCC 33323
Lactobacillus manihotivorans
Lactobacillus gasseri CECT 5714
Lactobacillus mindensis
Lactobacillus gasseri EX336960VC01
Lactobacillus mobilis
Lactobacillus gasseri EX336960VC02
Lactobacillus mucosae
Lactobacillus gasseri EX336960VC03
Lactobacillus mucosae LM1
Lactobacillus gasseri EX336960VC06
Lactobacillus murinus
Lactobacillus gasseri EX336960VC07
Lactobacillus murinus ASF361
Lactobacillus gasseri EX336960VC10
Lactobacillus guizhouensis
Lactobacillus gasseri EX336960VC13
Lactobacillus halophilus
Lactobacillus gasseri EX336960VC15
Lactobacillus hammesii
Lactobacillus gasseri JV-V03
Lactobacillus hamsteri
Lactobacillus gasseri K7
Lactobacillus harbinensis
Lactobacillus gasseri MV-22
Lactobacillus harbinensis DSM 16991
Lactobacillus gasseri SJ-9E-US
Lactobacillus hayakitensis
Lactobacillus gasseri SV-16A-US
Lactobacillus helveticus
Lactobacillus gastricus
Lactobacillus helveticus CIRM-BIA 101
Lactobacillus gastricus PS3
Lactobacillus helveticus CIRM-BIA 103
Lactobacillus genomosp. CT
Lactobacillus helveticus CIRM-BIA 104
Lactobacillus genomosp. C2
Lactobacillus helveticus CIRM-BIA 951
Lactobacillus ghanensis
Lactobacillus helveticus CIRM-BIA 953
Lactobacillus gigeriorum
Lactobacillus helveticus CNRZ32
Lactobacillus gigeriorum CRBIP 24.85
Lactobacillus helveticus DPC 4571
Lactobacillus graminis
Lactobacillus helveticus DSM 20075
Lactobacillus delbrueckii
Lactobacillus helveticus 1110
Lactobacillus delbrueckii subsp. bulgaricus
Lactobacillus helveticus H9
Lactobacillus helveticus MTCC 5463
Lactobacillus kunkeei
Lactobacillus helveticus R0052
Lactobacillus larvae
Lactobacillus helveticus subsp. jugurti
Lactobacillus leichmannii
Lactobacillus heterohiochii
Lactobacillus letivazi
Lactobacillus hilgardii
Lactobacillus lindneri
Lactobacillus hilgardii ATCC 8290
Lactobacillus malefermentans
Lactobacillus hokkaidonensis
Lactobacillus malefermentans KCTC 3548
Lactobacillus hominis
Lactobacillus sunkii
Lactobacillus hominis CRBIP 24.179
Lactobacillus taiwanensis
Lactobacillus homohiochii
Lactobacillus thailandensis
Lactobacillus hordei
Lactobacillus tucceti
Lactobacillus iatae
Lactobacillus ultunensis
Lactobacillus iners
Lactobacillus ultunensis DSM 16047
Lactobacillus iners AB-1
Lactobacillus uvarum
Lactobacillus iners ACS-070-V-Col3
Lactobacillus vaccinostcrcus
Lactobacillus iners ATCC 55195
Lactobacillus vaginalis
Lactobacillus iners DSM 13335
Lactobacillus vaginalis ATCC 49540
Lactobacillus iners LactinV OlVl-a
Lactobacillus vaginalis EX336960VC05
Lactobacillus iners LactinV 03Vl-b
Lactobacillus vaginalis EX336960VC11
Lactobacillus iners LactinV 09V1-C
Lactobacillus vaginalis EX336960VC12
Lactobacillus iners LactinV 11VI-d
Lactobacillus vermiforme
Lactobacillus iners LEAF 2052A-d
Lactobacillus versmoldensis
Lactobacillus iners LEAF 2053A-b
Lactobacillus versmoldensis KCTC 3814
Lactobacillus iners LEAF 2062A-hl
Lactobacillus vini
Lactobacillus iners LEAF 3008A-a
Lactobacillus vini DSM 20605
Lactobacillus iners SPIN 1401G
Lactobacillus vini JP7.8.9
Lactobacillus iners SPIN 2503V10-D
Lactobacillus zymae
Lactobacillus iners UPII 143-D
Lactobacillus sp.
Lactobacillus iners UPII 60-B
Lactobacillus sp. O-C-2
Lactobacillus ingluviei
Lactobacillus sp. 1-3-3
Lactobacillus ingluviei str. Autruche 4
Lactobacillus sp. 1.1424
Lactobacillus insectis
Lactobacillus nagelii
Lactobacillus intermedius
Lactobacillus namurensis
Lactobacillus intestinalis
Lactobacillus nantensis
Lactobacillus japonicus
Lactobacillus nasuensis
Lactobacillus jensenii
Lactobacillus nodensis
Lactobacillus jensenii 115-3-CHN
Lactobacillus nodensis NBRC 107160
Lactobacillus jensenii 1153
Lactobacillus odoratitoflii
Lactobacillus jensenii 208-1
Lactobacillus oeni
Lactobacillus jensenii 269-3
Lactobacillus oligofermentans
Lactobacillus jensenii 27-2-CHN
Lactobacillus oligofermentans LMG 22743
Lactobacillus jensenii EX533959VC02
Lactobacillus oris
Lactobacillus jensenii EX849587VC03
Lactobacillus oris F0423
Lactobacillus jensenii EX849587VC05
Lactobacillus oris PB013-T2-3
Lactobacillus jensenii EX849587VC06
Lactobacillus oryzae
Lactobacillus jensenii JV-V16
Lactobacillus otakiensis
Lactobacillus jensenii MD HE-70(2)
Lactobacillus otakiensis JCM 15040
Lactobacillus jensenii SJ-7A-US
Lactobacillus ozcnsis
Lactobacillus johnsonii
Lactobacillus panis
Lactobacillus johnsonii 135-1 -CHN
Lactobacillus pantheris
Lactobacillus johnsonii 16
Lactobacillus parabrevis
Lactobacillus johnsonii ATCC 33200
Lactobacillus parabrevis ATCC 53295
Lactobacillus johnsonii DPC 6026
Lactobacillus parabuchneii
Lactobacillus johnsonii FT9785
Lactobacillus paracollinoides
Lactobacillus johnsonii NCC 533
Lactobacillus parafarraginis
Lactobacillus johnsonii pfOl
Lactobacillus parafarraginis F0439
Lactobacillus kalixensis
Lactobacillus parakefiri
Lactobacillus kefiranofaciens
Lactobacillus paralimentarius
Lactobacillus kefiranofaciens subsp. kefiranofaciens
Lactobacillus parapiantarum
Lactobacillus kefiranofaciens subsp. kefirgranum
Lactobacillus pasteurii
Lactobacillus kefiranofaciens ZW3
Lactobacillus pasteurii CRBIP 24.76
Lactobacillus kefiri
Lactobacillus pentosus
Lactobacillus kefiri JCM 5818
Lactobacillus pentosus IG1
Lactobacillus kimchicus
Lactobacillus pentosus KCA1
Lactobacillus kimchicus JCM 15530
Lactobacillus pentosus MP-10
Lactobacillus kimchiensis
Lactobacillus perolens
Lactobacillus kimchii
Lactobacillus plantarum
Lactobacillus kisonensis
Lactobacillus plantarum 16
Lactobacillus kisonensis F0435
Lactobacillus plantarum 2025
Lactobacillus kitasatonis
Lactobacillus plantarum 2165
Lactobacillus plantarum 4_3
Lactobacillus mminis
Lactobacillus plantamm AY01
Lactobacillus mminis ATCC 25644
Lactobacillus plantamm CMPG5300
Lactobacillus mminis ATCC 27782
Lactobacillus plantarum DOMLa
Lactobacillus mminis SPM0211
Lactobacillus plantamm EGD-AQ4
Lactobacillus saerimneri
Lactobacillus plantamm IPLA88
Lactobacillus saerimneri 30a
Lactobacillus plantamm JDM1
Lactobacillus saerimneri DSM 16049
Lactobacillus plantarum subsp. argentoratensis
Lactobacillus sakei
Lactobacillus plantamm subsp. plantarum
Lactobacillus sakei dgh6
Lactobacillus plantamm subsp. plantamm ATCC 14917
Lactobacillus sakei L45
Lactobacillus plantamm subsp. plantarum KCA-1
Lactobacillus sakei subsp. carnosus
Lactobacillus plantarum subsp. plantarum NC8
Lactobacillus sakei subsp. carnosus DSM 15831
Lactobacillus plantamm subsp. plantamm P-8
Lactobacillus sakei subsp. sakei
Lactobacillus plantamm subsp. plantamm R0403
Lactobacillus sakei subsp. sakei 23K
Lactobacillus plantamm subsp. plantamm ST-III
Lactobacillus sakei subsp. sakei LS25
Lactobacillus plantarum UCMA 3037
Lactobacillus salivarius
Lactobacillus plantamm WCFS1
Lactobacillus salivarius ACS-116-V-Col5a
Lactobacillus plantamm ZJ316
Lactobacillus salivarius ATCC 11741
Lactobacillus pobuzihii
Lactobacillus salivarius B-30514
Lactobacillus pobuzihii E100301
Lactobacillus salivarius CECT 5713
Lactobacillus pontis
Lactobacillus salivarius CELA2
Lactobacillus psittaci
Lactobacillus salivarius cp400
Lactobacillus psittaci DSM 15354
Lactobacillus salivarius DPC 6502
Lactobacillus rapi
Lactobacillus salivarius GJ-24
Lactobacillus rennini
Lactobacillus salivarius NTAS840
Lactobacillus reuteri
Lactobacillus salivarius SMXD51
Lactobacillus reuteri 100-23
Lactobacillus salivarius str. Ren
Lactobacillus reuteri 1063
Lactobacillus salivarius UCC118
Lactobacillus reuteri ATCC 53608
Lactobacillus sanfranciscensis
Lactobacillus reuteri CF48-3A
Lactobacillus sanfranciscensis TMW 1.1304
Lactobacillus reuteri DSM 20016
Lactobacillus saniviri
Lactobacillus reuteri F275
Lactobacillus satsumensis
Lactobacillus reuteri 15007
Lactobacillus secaliphilus
Lactobacillus reuteri JCM 1112
Lactobacillus senioris
Lactobacillus reuteri lpuph
Lactobacillus senmaizukei
Lactobacillus reuteri mlc3
Lactobacillus senmaizukei NBRC 103853
Lactobacillus reuteri MM2-2
Lactobacillus sharpeae
Lactobacillus reuteri MM2-3
Lactobacillus sharpeae JCM 1186
Lactobacillus reuteri MM4-1A
Lactobacillus shenzhenensis
Lactobacillus reuteri SD2112
Lactobacillus shenzhenensis LY-73
Lactobacillus reuteri TD1
Lactobacillus silagei
Lactobacillus rhamnosus
Lactobacillus siliginis
Lactobacillus rhamnosus 2166
Lactobacillus similis
Lactobacillus rhamnosus ATCC 21052
Lactobacillus similis JCM 2765
Lactobacillus rhamnosus ATCC 8530
Lactobacillus spicheri
Lactobacillus rhamnosus CASL
Lactobacillus sucicola
Lactobacillus rhamnosus CRL1505
Lactobacillus suebicus
Lactobacillus rhamnosus DSM 14870
Lactobacillus suebicus KCTC 3549
Lactobacillus rhamnosus GG
Lactobacillus sp. 14.2.14
Lactobacillus rhamnosus LMG 25859
Lactobacillus sp. 14.2.15
Lactobacillus rhamnosus LMG 27229
Lactobacillus sp. 14.2.18
Lactobacillus rhamnosus HN001
Lactobacillus sp. 14.2.20
Lactobacillus rhamnosus K32
Lactobacillus sp. 14.2.30
Lactobacillus rhamnosus L31
Lactobacillus sp. 1 4.2.31
Lactobacillus rhamnosus L33
Lactobacillus sp. 14.2.33
Lactobacillus rhamnosus L34
Lactobacillus sp. 14.2.37
Lactobacillus rhamnosus L35
Lactobacillus sp. 14.2.39
Lactobacillus rhamnosus Ec 705
Lactobacillus sp. 14.2.4
Lactobacillus rhamnosus LMS2-1
Lactobacillus sp. 14.2.41
Lactobacillus rhamnosus LOCK900
Lactobacillus sp. 14.2.46
Lactobacillus rhamnosus LOCK908
Lactobacillus sp. 14.2.48
Lactobacillus rhamnosus LRHMDP2
Lactobacillus sp. 14.2.9
Lactobacillus rhamnosus LRHMDP3
Lactobacillus sp. 14.8.15
Lactobacillus rhamnosus MSUIS1
Lactobacillus sp. 14.8.19
Lactobacillus rhamnosus MTCC 5462
Lactobacillus sp. 14.8.23
Lactobacillus rhamnosus NBRC 3425
Lactobacillus sp. 14.8.24
Lactobacillus rhamnosus R0011
Lactobacillus sp. 14.8.36
Lactobacillus rogosae
Lactobacillus sp. 14.8.40
Lactobacillus rossiae
Lactobacillus sp. 14.8.43
Lactobacillus rossiae DSM 15814
Lactobacillus sp. 14.8.44
Lactobacillus sp. 14.8.6
Lactobacillus sp. 7.8.26
Lactobacillus sp. 14.8.7
Lactobacillus sp. 7.8.27
Lactobacillus sp. 14B10
Lactobacillus sp. 7.8.33
Lactobacillus sp. 166
Lactobacillus sp. 7.8.6
Lactobacillus sp. 16DCCH01MX
Lactobacillus sp. 70811
Lactobacillus sp. 18BSM
Lactobacillus sp. 70819
Lactobacillus sp. 19-2
Lactobacillus sp. 71
Lactobacillus sp. 19DCCH01MX
Lactobacillus sp. 711
Lactobacillus sp. 1L
Lactobacillus sp. 100-23
Lactobacillus sp. 20(2010)
Lactobacillus sp. 100-5
Lactobacillus sp. 2011 Ileo VSA CI
Lactobacillus sp. 11050
Lactobacillus sp. 2011 Ileo VSA C5
Lactobacillus sp. 11102
Lactobacillus sp. 2011 Ileo VSA D2
Lactobacillus sp. 120-6-20
Lactobacillus sp. 2011 Ileo VSA E2
Lactobacillus sp. 12IB
Lactobacillus sp. 201 l_Oral_VSA C7
Lactobacillus sp. 123B
Lactobacillus sp. 20326H4L1
Lactobacillus sp. 14-3-19
Lactobacillus sp. 24DCCH01 MX
Lactobacillus sp. 14.2.12
Lactobacillus sp. 3-6
Lactobacillus sp. 14.2.13
Lactobacillus sp. 3.1.1
Lactobacillus sp. Anhor4
Lactobacillus sp. 3.2.22
Lactobacillus sp. Aiilioto7
Lactobacillus sp. 3.2.35
Lactobacillus sp. Anhoto8
Lactobacillus sp. 3.8.18
Lactobacillus sp. Anuhmtol3
Lactobacillus sp. 3.8.40
Lactobacillus sp. Anuhmto23
Lactobacillus sp. 3.8.42
Lactobacillus sp. ARB2
Lactobacillus sp. 3.8.8
Lactobacillus sp. Arif Mardan-
Lactobacillus sp. 30.2.8
Lactobacillus sp. AS5
Lactobacillus sp. 30A
Lactobacillus sp. ASF360
Lactobacillus sp. 30BPM
Lactobacillus sp. ATCC 8291
Lactobacillus sp. 326
Lactobacillus sp. Atm5
Lactobacillus sp. 34-10B
Lactobacillus sp. Autruche 4
Lactobacillus sp. 39D2CCL02MX
Lactobacillus sp. Autruche 5
Lactobacillus sp. 39DCCL02MX
Lactobacillus sp. B 225
Lactobacillus sp. 3AB9
Lactobacillus sp. B 226
Lactobacillus sp. 3b
Lactobacillus sp. B 227
Lactobacillus sp. 3d
Lactobacillus sp. B 228
Lactobacillus sp. 3F11
Lactobacillus sp. B 229
Lactobacillus sp. 41DCCL02MX
Lactobacillus sp. B 230
Lactobacillus sp. 43D2CCL02MX
Lactobacillus sp. B 236
Lactobacillus sp. 43DCCL02MX
Lactobacillus sp. B 237
Lactobacillus sp. 45
Lactobacillus sp. B 238
Lactobacillus sp. 459
Lactobacillus sp. B 239
Lactobacillus sp. 46-211
Lactobacillus sp. B 245
Lactobacillus sp. 47DCCL02MX
Lactobacillus sp. B 246
Lactobacillus sp. 49DCCL02MX
Lactobacillus sp. B 247
Lactobacillus sp. 4B13
Lactobacillus sp. B 248
Lactobacillus sp. 4B31
Lactobacillus sp. B 249
Lactobacillus sp. 5-1-2
Lactobacillus sp. B 250
Lactobacillus sp. 52A
Lactobacillus sp. B 251
Lactobacillus sp. 54DCEP01MX
Lactobacillus sp. B 252
Lactobacillus sp. 59DCEP01MX
Lactobacillus sp. B 253
Lactobacillus sp. 5D32
Lactobacillus sp. B 254
Lactobacillus sp. 6225121
Lactobacillus sp. B 255
Lactobacillus sp. 6225335
Lactobacillus sp. B10
Lactobacillus sp. 6225616
Lactobacillus sp. B13
Lactobacillus sp. 62DACEP01MX
Lactobacillus sp. B16
Lactobacillus sp. 66c
Lactobacillus sp. B164
Lactobacillus sp. 6D3
Lactobacillus sp. B18
Lactobacillus sp. 7-19
Lactobacillus sp. B2
Lactobacillus sp. 7.2.21
Lactobacillus sp. B21
Lactobacillus sp. 7.2.29
Lactobacillus sp. B22
Lactobacillus sp. 7.2.33
Lactobacillus sp. B3
Lactobacillus sp. 7.2.35
Lactobacillus sp. B3(2009)
Lactobacillus sp. 7.2.36
Lactobacillus sp. B4
Lactobacillus sp. 7.2.40
Lactobacillus sp. B5
Lactobacillus sp. 7.2.46
Lactobacillus sp. B5406
Lactobacillus sp. 7.2.48
Lactobacillus sp. B5407
Lactobacillus sp. 7.2.49
Lactobacillus sp. B6
Lactobacillus sp. 7.2.50
Lactobacillus sp. B6(2012)
Lactobacillus sp. 7.8.15
Lactobacillus sp. B7
Lactobacillus sp. 7.8.17
Lactobacillus sp. B8
Lactobacillus sp. B9
Lactobacillus sp. Adhmtol
Lactobacillus sp. BB9
Lactobacillus sp. Adhmtol5
Lactobacillus sp. BBDP73
Lactobacillus sp. Adhmtol9
Lactobacillus sp. BCRC16000
Lactobacillus sp. Adhmto21
Lactobacillus sp. BH0900
Lactobacillus sp. Adporo6
Lactobacillus sp. 713
Lactobacillus sp. AF20(2010)
Lactobacillus sp. 74(2011)
Lactobacillus sp. AF26(2010)
Lactobacillus sp. 7 1 47FAA
Lactobacillus sp. Afhotl
Lactobacillus sp. 7b
Lactobacillus sp. AFL13-2
Lactobacillus sp. 8525126
Lactobacillus sp. AFL17-5
Lactobacillus sp. 88
Lactobacillus sp. AFL18-2
Lactobacillus sp. 8BAM
Lactobacillus sp. AFL18-5
Lactobacillus sp. 9C4
Lactobacillus sp. AFL19-3
Lactobacillus sp. 9C6
Lactobacillus sp. Afpor8
Lactobacillus sp. 9D10
Lactobacillus sp. Afpotol3
Lactobacillus sp. 9D6
Lactobacillus sp. Afpolol4
Lactobacillus sp. 9D8
Lactobacillus sp. Afpoto7
Lactobacillus sp. AA
Lactobacillus sp. AI197
Lactobacillus sp. Aabbtol6
Lactobacillus sp. AI460
Lactobacillus sp. Aabbto7
Lactobacillus sp. AI461
Lactobacillus sp. Aahmrol5
Lactobacillus sp. AK11 3
Lactobacillus sp. Aahmtol2
Lactobacillus sp. AK21
Lactobacillus sp. Aahonto7
Lactobacillus sp. Akhmbto4
Lactobacillus sp. ABO 15
Lactobacillus sp. Akhmr6
Lactobacillus sp. AB032
Lactobacillus sp. Akhmro 1
Lactobacillus sp. ABO 5
Lactobacillus sp. Akhmtol8
Lactobacillus sp. ABO 5-1
Lactobacillus sp. Aldimto2
Lactobacillus sp. AB06
Lactobacillus sp. Akpobrol
Lactobacillus sp. ab2
Lactobacillus sp. Akporo7
Lactobacillus sp. ab3-wl
Lactobacillus sp. AL2
Lactobacillus sp. AB511
Lactobacillus sp. AL5
Lactobacillus sp. AB511-2
Lactobacillus sp. Alhmlto4
Lactobacillus sp. AB5115-9
Lactobacillus sp. Alhm2tol 1
Lactobacillus sp. AB5216-2
Lactobacillus sp. Alhonto3
Lactobacillus sp. AB523-1
Lactobacillus sp. Alhonto4
Lactobacillus sp. AB5252
Lactobacillus sp. Am 09
Lactobacillus sp. AB5261-2
Lactobacillus sp. AMC1
Lactobacillus sp. AB5262
Lactobacillus sp. AMC2
Lactobacillus sp. AB5281
Lactobacillus sp. AmmhmR15
Lactobacillus sp. AB5282
Lactobacillus sp. AmmhmR3
Lactobacillus sp. ab6
Lactobacillus sp. AmmhmR5
Lactobacillus sp. ABRIINW-GOL4
Lactobacillus sp. AmmhmT7
Lactobacillus sp. ABRIINW.F58
Lactobacillus sp. AmmohmiT
Lactobacillus sp. ABT LI
Lactobacillus sp. Ammohmr22
Lactobacillus sp. ABT L2
Lactobacillus sp. Ammohml5
Lactobacillus sp. AbxANB3
Lactobacillus sp. Ammoporl3
Lactobacillus sp. AbxANB4
Lactobacillus sp. Ammopor2
Lactobacillus sp. ACD7
Lactobacillus sp. AmmpolR3
Lactobacillus sp. Achmtol6
Lactobacillus sp. AmmpolR6
Lactobacillus sp. Achmto2
Lactobacillus sp. Amsbbrl7
Lactobacillus sp. AcjLac1
Lactobacillus sp. Amsbbrl9
Lactobacillus sp. AcjLac10
Lactobacillus sp. Amsbbr2
Lactobacillus sp. AcjLac11
Lactobacillus sp. Amsbbr24
Lactobacillus sp. AcjLac12
Lactobacillus sp. Amsbbrfi
Lactobacillus sp. AcjLac13
Lactobacillus sp. Amsbbtll
Lactobacillus sp. AcjLac14
Lactobacillus sp. DSM 15502
Lactobacillus sp. AcjLac15
Lactobacillus sp. DSM 20197
Lactobacillus sp. AcjLac16
Lactobacillus sp. DumLac1
Lactobacillus sp. AcjLac17
Lactobacillus sp. DumLac10
Lactobacillus sp. AcjLac18
Lactobacillus sp. DumLac11
Lactobacillus sp. AcjLac3
Lactobacillus sp. DumLac12
Lactobacillus sp. AcjLac4
Lactobacillus sp. DumLac13
Lactobacillus sp. AcjLac5
Lactobacillus sp. DumLac14
Lactobacillus sp. AcjLac6
Lactobacillus sp. DumLac15
Lactobacillus sp. AcjLac7
Lactobacillus sp. DumLac17
Lactobacillus sp. AcjLac8
Lactobacillus sp. DumLac18
Lactobacillus sp. AcjLac9
Lactobacillus sp. DumLac19
Lactobacillus sp. Acpor9
Lactobacillus sp. DumLac2
Lactobacillus sp. Adhmro12
Lactobacillus sp. DumLac20
Lactobacillus sp. Adhmro7
Lactobacillus sp. DumLac21
Lactobacillus sp. DumLac22
Lactobacillus sp. GL1
Lactobacillus sp. DumLac23
Lactobacillus sp. GL2
Lactobacillus sp. DuiuLac24
Lactobacillus sp. GM 01
Lactobacillus sp. DumLac25
Lactobacillus sp. GS21
Lactobacillus sp. DumLac26
Lactobacillus sp. GTH1
Lactobacillus sp. DumLac27
Lactobacillus sp. GTH10
Lactobacillus sp. DumLac28
Lactobacillus sp. GTH13
Lactobacillus sp. DumLac29
Lactobacillus sp. GTH15
Lactobacillus sp. DumLac3
Lactobacillus sp. GTH17
Lactobacillus sp. DumLac30
Lactobacillus sp. GTH18
Lactobacillus sp. DumLac31
Lactobacillus sp. GTH2
Lactobacillus sp. DumLac32
Lactobacillus sp. GTH20
Lactobacillus sp. DuinLac33
Lactobacillus sp. GTH22
Lactobacillus sp. DumLac34
Lactobacillus sp. GTH24
Lactobacillus sp. DumLac3 5
Lactobacillus sp. GTH26
Lactobacillus sp. DumLac36
Lactobacillus sp. GTH28
Lactobacillus sp. DumLac37
Lactobacillus sp. GTH29
Lactobacillus sp. DumLac38
Lactobacillus sp. GTH30
Lactobacillus sp. DumLac39
Lactobacillus sp. GTH32
Lactobacillus sp. DuniLac4
Lactobacillus sp. GTH33
Lactobacillus sp. DumLac40
Lactobacillus sp. GTH5
Lactobacillus sp. DumLac41
Lactobacillus sp. GTH6
Lactobacillus sp. DumLac42
Lactobacillus sp. GTH7
Lactobacillus sp. DumLac43
Lactobacillus sp. GTH8
Lactobacillus sp. DuniLac44
Lactobacillus sp. GTP1
Lactobacillus sp. DumLac45
Lactobacillus sp. GTP2
Lactobacillus sp. DumLac46
Lactobacillus sp. GTP3
Lactobacillus sp. DuuiLac47
Lactobacillus sp. GTP4
Lactobacillus sp. DumLac48
Lactobacillus sp. GTP5
Lactobacillus sp. DumLac49
Lactobacillus sp. GTP6
Lactobacillus sp. DumLac5
Lactobacillus sp. GTR1
Lactobacillus sp. DuniLac50
Lactobacillus sp. GTR2
Lactobacillus sp. DumLac51
Lactobacillus sp. GTS2
Lactobacillus sp. DumLac5 2
Lactobacillus sp. GV6
Lactobacillus sp. DumLac53
Lactobacillus sp. H1HS25N
Lactobacillus sp. DumLac54
Lactobacillus sp. II1IIS38N
Lactobacillus sp. DumLac6
Lactobacillus sp. H4
Lactobacillus sp. DumLac8
Lactobacillus sp. H4bbl8N
Lactobacillus sp. DumLac9
Lactobacillus sp. H4BP4N
Lactobacillus sp. El2
Lactobacillus sp. II6IIS1N
Lactobacillus sp. EG 12
Lactobacillus sp. H6HS21N
Lactobacillus sp. EL3
Lactobacillus sp. H6HS25N
Lactobacillus sp. EL6
Lactobacillus sp. H6HS28N
Lactobacillus sp. EL7
Lactobacillus sp. Hadi Naser-1
Lactobacillus sp. EMML 3041
Lactobacillus sp. Hadi Tajabadi-1
Lactobacillus sp. F-2
Lactobacillus sp. HG209
Lactobacillus sp. F1
Lactobacillus sp. HJ1
Lactobacillus sp. Fl 1
Lactobacillus sp. HJ2
Lactobacillus sp. F16
Lactobacillus sp. HL7
Lactobacillus sp. F2
Lactobacillus sp. Hma11N
Lactobacillus sp. F2(2009)
Lactobacillus sp. Hma2
Lactobacillus sp. F31
Lactobacillus sp. Hma2N
Lactobacillus sp. F52
Lactobacillus sp. Hma8
Lactobacillus sp. F7
Lactobacillus sp. HmaSN
Lactobacillus sp. Faegheh Dilah-1
Lactobacillus sp. Hon2
Lactobacillus sp. Faegheh Hadi-1
Lactobacillus sp. Hon2N
Lactobacillus sp. FAM-02
Lactobacillus sp. HRPRS2
Lactobacillus sp. FAM-04
Lactobacillus sp. HRPRTF.3
Lactobacillus sp. fhon 13
Lactobacillus sp. HRRO′lT
Lactobacillus sp. Fhonl3N
Lactobacillus sp. HRROT3
Lactobacillus sp. Fhon2N
Lactobacillus sp. HRROTE4
Lactobacillus sp. FKTJ23
Lactobacillus sp. HumaH4
Lactobacillus sp. FL1
Lactobacillus sp. HumL3
Lactobacillus sp. FL2
Lactobacillus sp. ID9203
Lactobacillus sp. FL4
Lactobacillus sp. IDLAc
Lactobacillus sp. FS1111
Lactobacillus sp. IDSAc
Lactobacillus sp. FT
Lactobacillus sp. IJ-K2
Lactobacillus sp. Gl
Lactobacillus sp. IL3
Lactobacillus sp. G24
Lactobacillus sp. IV-132
Lactobacillus sp. GB001
Lactobacillus sp. BH1398
Lactobacillus sp. BH1480
Lactobacillus sp. CL6
Lactobacillus sp. Bin4
Lactobacillus sp. CL8
Lactobacillus sp. Bin4N
Lactobacillus sp. CL9
Lactobacillus sp. Biut2
Lactobacillus sp. CLE-4
Lactobacillus sp. Biut2N
Lactobacillus sp. Com4
Lactobacillus sp. BJ H8-4
Lactobacillus sp. CPP1
Lactobacillus sp. BJ32B3
Lactobacillus sp. CR-609S
Lactobacillus sp. BJ32B4D
Lactobacillus sp. CR-6AS
Lactobacillus sp. BJ32B4S
Lactobacillus sp. CR-7AS
Lactobacillus sp. BJ4-6B
Lactobacillus sp. CRA21
Lactobacillus sp. BL263
Lactobacillus sp. CS10
Lactobacillus sp. BL301
Lactobacillus sp. CS24.2
Lactobacillus sp. BL302
Lactobacillus sp. CWBI/B-659/(E912)
Lactobacillus sp. BL303
Lactobacillus sp. CY1
Lactobacillus sp. BL304
Lactobacillus sp. D2-2-1
Lactobacillus sp. BLB1a
Lactobacillus sp. D5-2
Lactobacillus sp. BLB 1b
Lactobacillus sp. D6-4
Lactobacillus sp. BLB1c
Lactobacillus koreensis
Lactobacillus sp. BLB2
Lactobacillus sp. DCY65
Lactobacillus sp. BLB3
Lactobacillus sp. DCY75
Lactobacillus sp. Bma5
Lactobacillus sp. DF1
Lactobacillus sp. Bma5N
Lactobacillus sp. DI71
Lactobacillus sp. BS-05
Lactobacillus sp. DI83
Lactobacillus sp. BS-09
Lactobacillus sp. Dilah Makhdzir-1
Lactobacillus sp. BS-10
Lactobacillus sp. DJF R156
Lactobacillus sp. BS-11
Lactobacillus sp. DJF CR11
Lactobacillus sp. BS-15
Lactobacillus sp. DJF RP24
Lactobacillus sp. BS-19
Lactobacillus sp. DJF SLA41
Lactobacillus sp. BS-22
Lactobacillus sp. DJF WC57
Lactobacillus sp. BS-27
Lactobacillus sp. DL-DW
Lactobacillus sp. BS-29
Lactobacillus sp. DL3
Lactobacillus sp. BS-32
Lactobacillus sp. DL6
Lactobacillus sp. BS-33
Lactobacillus sp. Dorsata
Lactobacillus sp. BS-36
Lactobacillus sp. DSA-8Z
Lactobacillus sp. BS1
Lactobacillus sp. L24
Lactobacillus sp. BT6
Lactobacillus sp. L25
Lactobacillus sp. BTLCH M1/2
Lactobacillus sp. L26
Lactobacillus sp. C30An22
Lactobacillus sp. L27
Lactobacillus sp. C30An7
Lactobacillus sp. L28
Lactobacillus sp. C30An8
Lactobacillus sp. L29
Lactobacillus sp. C33LV5
Lactobacillus sp. L3
Lactobacillus sp. C56
Lactobacillus sp. L30
Lactobacillus sp. C9
Lactobacillus sp. L31
Lactobacillus sp. CCC 96S9L
Lactobacillus sp. L32
Lactobacillus sp. CCTCC ‘M 2011381’
Lactobacillus sp. L33
Lactobacillus sp. CD6
Lactobacillus sp. L34
Lactobacillus sp. cemb29
Lactobacillus sp. L35
Lactobacillus sp. CF38
Lactobacillus sp. L37
Lactobacillus sp. CHU-R
Lactobacillus sp. L376
Lactobacillus sp. CIA-04
Lactobacillus sp. L38
Lactobacillus sp. CTA-40BC
Lactobacillus sp. L39
Lactobacillus sp. CIDCA 83110
Lactobacillus sp. L4
Lactobacillus sp. CIDCA 83111
Lactobacillus sp. L40
Lactobacillus sp. CIDCA 83116
Lactobacillus sp. L41
Lactobacillus sp. CIDCA 8314
Lactobacillus sp. L42
Lactobacillus sp. CIDCA 8315
Lactobacillus sp. L43
Lactobacillus sp. CIDCA 8317
Lactobacillus sp. L44
Lactobacillus sp. CIDCA 8321
Lactobacillus sp. L45
Lactobacillus sp. CIDCA 8325
Lactobacillus sp. L5gt
Lactobacillus sp. CIDCA 8326
Lactobacillus sp. L5km
Lactobacillus sp. CIDCA 8332
Lactobacillus sp. L6
Lactobacillus sp. CIDCA 8337
Lactobacillus sp. L6 N139
Lactobacillus sp. CIDCA 8343
Lactobacillus sp. L6 N18
Lactobacillus sp. CIDCA 8345
Lactobacillus sp. L6 N23
Lactobacillus sp. CIDCA 8347
Lactobacillus sp. L6 N6
Lactobacillus sp. CIDCA 8348
Lactobacillus sp. L6 N68
Lactobacillus sp. CL
Lactobacillus sp. L63(2011)
Lactobacillus sp. CL11
Lactobacillus sp. L67
Lactobacillus sp. CL3
Lactobacillus sp. L7
Lactobacillus sp. CL5
Lactobacillus sp. L8
Lactobacillus sp. L8(2006)
Lactobacillus sp. MA
Lactobacillus sp. L9
Lactobacillus sp. Makhdzir Dilah-1
Lactobacillus sp. L9(2006)
Lactobacillus sp. Makhdzir Mardan-1
Lactobacillus sp. L9(2008)
Lactobacillus sp. Makhdzir Naser-1
Lactobacillus sp. LA-6
Lactobacillus sp. Mardan Mustafa-1
Lactobacillus sp. LAB-1
Lactobacillus sp. Mardan Naser-1
Lactobacillus sp. LAB-3
Lactobacillus sp. Mardan Yazid-1
Lactobacillus sp. LAB 10
Lactobacillus sp. Mardanium
Lactobacillus sp. lab 11
Lactobacillus sp. mashak 26
Lactobacillus sp. lab 13
Lactobacillus sp. MB1A
Lactobacillus sp. Iab2
Lactobacillus sp. MB1C
Lactobacillus sp. Lac 1
Lactobacillus sp. MB1D
Lactobacillus sp. Lac 2
Lactobacillus sp. MbBbr1
Lactobacillus sp. Lac 3
Lactobacillus sp. MbBipro17
Lactobacillus sp. Lac 4
Lactobacillus sp. MbBipro19
Lactobacillus sp. Lac 5
Lactobacillus sp. MbBipro7
Lactobacillus sp. Lac 6
Lactobacillus sp. MbBipto3
Lactobacillus sp. Lact01
Lactobacillus sp. MbHmrol
Lactobacillus sp. Lact02
Lactobacillus sp. MbHmro5
Lactobacillus sp. Lact03
Lactobacillus sp. Mbhoto3
Lactobacillus sp. Lact04
Lactobacillus sp. Mbhsr5
Lactobacillus sp. Lact05
Lactobacillus sp. Mbobb2r6
Lactobacillus sp. Lact06
Lactobacillus sp. Mbohmt7
Lactobacillus sp. Lact0S
Lactobacillus sp. Mboho2r2
Lactobacillus sp. Lact09
Lactobacillus sp. Mbohs2rl 2
Lactobacillus sp. Lact11
Lactobacillus sp. Mbohs2t2
Lactobacillus sp. Lact12
Lactobacillus sp. Mbohs2t7
Lactobacillus sp. Lact13
Lactobacillus sp. Mbopo2r2
Lactobacillus sp. Lact14
Lactobacillus sp. Mbopo2t4
Lactobacillus sp. Lact15
Lactobacillus sp. Mbopo2t6
Lactobacillus sp. Ib01
Lactobacillus sp. MBUL75
Lactobacillus sp. LB1
Lactobacillus sp. MD-1
Lactobacillus sp. LB6
Lactobacillus sp. MEB1
Lactobacillus sp. LBS-27
Lactobacillus sp. MF-07
Lactobacillus sp. ljubLlr
Lactobacillus sp. MF1
Lactobacillus sp. ljubL4to
Lactobacillus sp. MF19(2010)
Lactobacillus sp. LM-17
Lactobacillus sp. MF213
Lactobacillus sp. LMG 17676
Lactobacillus sp. MF41(2010)
Lactobacillus sp. LOOC279
Lactobacillus sp. MF44(2010)
Lactobacillus sp. LQC 1642
Lactobacillus sp. MIB1
Lactobacillus sp. LQC 1677
Lactobacillus sp. MMP239
Lactobacillus sp. LQC 1693
Lactobacillus sp. MMP241
Lactobacillus sp. LQC 1930
Lactobacillus sp. MMP242
Lactobacillus sp. LQC 1937
Lactobacillus sp. MNFS-3
Lactobacillus sp. LQC 1938
Lactobacillus sp. MONT4
Lactobacillus sp. LQC 1942
Lactobacillus sp. MR-1
Lactobacillus sp. LQC 1951
Lactobacillus sp. MR-2
Lactobacillus sp. LQC 1954
Lactobacillus sp. MRS-II22
Lactobacillus sp. LQC 1958
Lactobacillus sp. MRS-III06
Lactobacillus sp. LQC 1959
Lactobacillus sp. MRSB
Lactobacillus sp. LSI
Lactobacillus sp. MSUGMIR-3
Lactobacillus sp. LS3
Lactobacillus sp. MWBPC 1-3-1
Lactobacillus sp. LS7
Lactobacillus sp. MYMRS/TEN2
Lactobacillus sp. Is79
Lactobacillus sp. MYMRS/TLLT1
Lactobacillus sp. LS8
Lactobacillus sp. MYMRS/TLU1-T
Lactobacillus sp. Lu3
Lactobacillus sp. MYTPY/TEN3
Lactobacillus sp. Lu5
Lactobacillus sp. Nl-5-2
Lactobacillus sp. Lu7
Lactobacillus sp. N19
Lactobacillus sp. M.U.L2
Lactobacillus sp. N2-7-1
Lactobacillus sp. Ml
Lactobacillus sp. N20
Lactobacillus sp. M1T3B2
Lactobacillus sp. N27
Lactobacillus sp. M1T4B2
Lactobacillus sp. N3-1-1
Lactobacillus sp. M20
Lactobacillus sp. N3-10-1
Lactobacillus sp. M23
Lactobacillus sp. N3-6
Lactobacillus sp. M2T2B4
Lactobacillus sp. N4-4
Lactobacillus sp. M3T1B1
Lactobacillus sp. N4-6
Lactobacillus sp. M3T1B2
Lactobacillus sp. N4-9
Lactobacillus sp. M3T1B5
Lactobacillus sp. N54
Lactobacillus sp. M8
Lactobacillus sp. Naser Makhdzir-1
Lactobacillus sp. M9-1
Lactobacillus sp. Naser Tajabadi-1
Lactobacillus sp. NBRC 101665
Lactobacillus sp. NBRC 107254
Lactobacillus sp. NBRC 101976
Lactobacillus sp. NBRC 107255
Lactobacillus sp. NBRC 106011
Lactobacillus sp. NBRC 107257
Lactobacillus sp. NBRC 106019
Lactobacillus sp. NBRC 107258
Lactobacillus sp. NBRC 106020
Lactobacillus sp. NBRC 107259
Lactobacillus sp. NBRC 106022
Lactobacillus sp. NBRC 107261
Lactobacillus sp. NBRC 106024
Lactobacillus sp. NBRC 107262
Lactobacillus sp. NBRC 106029
Lactobacillus sp. NBRC 107263
Lactobacillus sp. NBRC 106038
Lactobacillus sp. NBRC 107265
Lactobacillus sp. NBRC 106039
Lactobacillus sp. NBRC 107266
Lactobacillus sp. NBRC 106040
Lactobacillus sp. NBRC 107267
Lactobacillus sp. NBRC 106041
Lactobacillus sp. NBRC 107268
Lactobacillus sp. NBRC 106042
Lactobacillus sp. NBRC 107270
Lactobacillus sp. NBRC 106044
Lactobacillus sp. NBRC 107273
Lactobacillus sp. NBRC 106045
Lactobacillus sp. NBRC 107274
Lactobacillus sp. NBRC 106046
Lactobacillus sp. NBRC 107275
Lactobacillus sp. NBRC 106047
Lactobacillus sp. NBRC 107276
Lactobacillus sp. NBRC 107174
Lactobacillus sp. NBRC 107279
Lactobacillus sp. NBRC 107175
Lactobacillus sp. NBRC 107282
Lactobacillus sp. NBRC 107177
Lactobacillus sp. NBRC 107283
Lactobacillus sp. NRRC 1071 79
Lactobacillus sp. NRRC 107284
Lactobacillus sp. NBRC 107180
Lactobacillus sp. NBRC 107285
Lactobacillus sp. NBRC 107181
Lactobacillus sp. NBRC 107286
Lactobacillus sp. NBRC 107182
Lactobacillus sp. NBRC 107288
Lactobacillus sp. NRRC 1071 83
Lactobacillus sp. NBRC 1 07289
Lactobacillus sp. NBRC 107184
Lactobacillus sp. NBRC 107290
Lactobacillus sp. NBRC 107185
Lactobacillus sp. NBRC 107292
Lactobacillus sp. NBRC 107187
Lactobacillus sp. NBRC 107293
Lactobacillus sp. NBRC 107188
Lactobacillus sp. NBRC 107294
Lactobacillus sp. NBRC 107191
Lactobacillus sp. NBRC 107295
Lactobacillus sp. NBRC 107192
Lactobacillus sp. NBRC 107297
Lactobacillus sp. NBRC 107194
Lactobacillus sp. NBRC 107298
Lactobacillus sp. NBRC 107195
Lactobacillus sp. NBRC 107300
Lactobacillus sp. NBRC 107196
Lactobacillus sp. NBRC 107301
Lactobacillus sp. NBRC 107197
Lactobacillus sp. NBRC 107302
Lactobacillus sp. NBRC 107198
Lactobacillus sp. NBRC 107304
Lactobacillus sp. NBRC 107199
Lactobacillus sp. NBRC 107305
Lactobacillus sp. NBRC 107200
Lactobacillus sp. NBRC 107307
Lactobacillus sp. NBRC 107201
Lactobacillus sp. NBRC 107308
Lactobacillus sp. NBRC 107202
Lactobacillus sp. NBRC 107311
Lactobacillus sp. NBRC 107203
Lactobacillus sp. NBRC 107312
Lactobacillus sp. NRRC 107205
Lactobacillus sp. NBRC 107313
Lactobacillus sp. NBRC 107207
Lactobacillus sp. NBRC 107315
Lactobacillus sp. NBRC 107208
Lactobacillus sp. NBRC 107316
Lactobacillus sp. NBRC 107210
Lactobacillus sp. NBRC 107318
Lactobacillus sp. NRRC 107211
Lactobacillus sp. NBRC 107320
Lactobacillus sp. NBRC 107212
Lactobacillus sp. NBRC 107321
Lactobacillus sp. NBRC 107214
Lactobacillus sp. NBRC 107323
Lactobacillus sp. NBRC 107215
Lactobacillus sp. NBRC 107324
Lactobacillus sp. NBRC 107216
Lactobacillus sp. NBRC 107325
Lactobacillus sp. NBRC 107220
Lactobacillus sp. NBRC 107326
Lactobacillus sp. NBRC 107223
Lactobacillus sp. NBRC 107327
Lactobacillus sp. NBRC 107224
Lactobacillus sp. NBRC 107328
Lactobacillus sp. NRRC 107226
Lactobacillus sp. NBRC 107329
Lactobacillus sp. NBRC 107227
Lactobacillus sp. NBRC 107330
Lactobacillus sp. NBRC 107228
Lactobacillus sp. NBRC 107332
Lactobacillus sp. NBRC 107229
Lactobacillus sp. NBRC 107334
Lactobacillus sp. NRRC 107232
Lactobacillus sp. NBRC 1 07336
Lactobacillus sp. NBRC 107233
Lactobacillus sp. NBRC 107337
Lactobacillus sp. NBRC 107234
Lactobacillus sp. NBRC 107338
Lactobacillus sp. NBRC 107236
Lactobacillus sp. NBRC 107339
Lactobacillus sp. NBRC 107237
Lactobacillus sp. NBRC 107340
Lactobacillus sp. NBRC 107238
Lactobacillus sp. NBRC 107341
Lactobacillus sp. NBRC 107239
Lactobacillus sp. NBRC 107342
Lactobacillus sp. NBRC 107240
Lactobacillus sp. NBRC 107347
Lactobacillus sp. NBRC 107242
Lactobacillus sp. NBRC 107348
Lactobacillus sp. NRRC 107246
Lactobacillus sp. NBRC 107349
Lactobacillus sp. NBRC 107249
Lactobacillus sp. NBRC 107351
Lactobacillus sp. NBRC 107252
Lactobacillus sp. NBRC 107352
Lactobacillus sp. NBRC 107253
Lactobacillus sp. NBRC 14511
Lactobacillus sp. NBRC 14512
Lactobacillus sp. JCM 8637
Lactobacillus sp. NBRC 14513
Lactobacillus sp. JCM 8652
Lactobacillus sp. NBRC 3229
Lactobacillus sp. JCM 8653
Lactobacillus sp. NBRC 3231
Lactobacillus sp. JCM 9717
Lactobacillus sp. NBRC 3914
Lactobacillus sp. JCM 9721
Lactobacillus sp. NBRC 3954
Lactobacillus sp. JN05
Lactobacillus sp. NEQAS6172
Lactobacillus sp. JN1
Lactobacillus sp. NGRI 0001
Lactobacillus sp. JN10
Lactobacillus sp. NGRI 0130
Lactobacillus sp. JN2
Lactobacillus sp. NGRI 0130Q
Lactobacillus sp. JN3
Lactobacillus sp. NGRI 0304
Lactobacillus sp. JN4
Lactobacillus sp. NGRI 0305
Lactobacillus sp. JN5
Lactobacillus sp. NIR2
Lactobacillus sp. JN6
Lactobacillus sp. NIR20
Lactobacillus sp. JN7
Lactobacillus sp. NIR24
Lactobacillus sp. JN8
Lactobacillus sp. NIR4
Lactobacillus sp. JN9
Lactobacillus sp. NIR5
Lactobacillus sp. JSB1
Lactobacillus sp. NIR6
Lactobacillus sp. JV-2006
Lactobacillus sp. NIR7
Lactobacillus sp. JW04
Lactobacillus sp. NIR8
Lactobacillus sp. KC19
Lactobacillus sp. NIRD-P2
Lactobacillus sp. KC35b
Lactobacillus sp. NM120-1
Lactobacillus sp. KC36a
Lactobacillus sp. NM191-2
Lactobacillus sp. KC36b
Lactobacillus sp. NM191-3
Lactobacillus sp. KC38
Lactobacillus sp. NM48-2
Lactobacillus sp. KC45a
Lactobacillus sp. IV-136
Lactobacillus sp. KC45b
Lactobacillus sp. IV-145
Lactobacillus sp. KLB46
Lactobacillus sp. IWT246
Lactobacillus sp. KLB58
Lactobacillus sp. IWT248
Lactobacillus sp. KLB79
Lactobacillus sp. j0227
Lactobacillus sp. KLDS 1.0701
Lactobacillus sp. j0228
Lactobacillus sp. KLDS 1.0702
Lactobacillus sp. j0230
Lactobacillus sp. KLDS 1.0703
Lactobacillus sp. j0238
Lactobacillus sp. KLDS 1.0704
Lactobacillus sp. j0383
Lactobacillus sp. KLDS 1.0705
Lactobacillus sp. JC-11
Lactobacillus sp. KLDS 1.0706
Lactobacillus sp. JCM 1013
Lactobacillus sp. KLDS 1.0707
Lactobacillus sp. JCM 1033
Lactobacillus sp. KLDS 1.0708
Lactobacillus sp. JCM 1034
Lactobacillus sp. KLDS 1.0709
Lactobacillus sp. JCM 1035
Lactobacillus sp. KLDS 1.0710
Lactobacillus sp. JCM 1088
Lactobacillus sp. KLDS 1.0711
Lactobacillus sp. JCM 1102
Lactobacillus sp. KLDS 1.0712
Lactobacillus sp. JCM 11039
Lactobacillus sp. KLDS 1.0713
Lactobacillus sp. JCM 1177
Lactobacillus sp. KLDS 1.0714
Lactobacillus sp. JCM 1179
Lactobacillus sp. KLDS 1.0715
Lactobacillus sp. JCM 1183
Lactobacillus sp. KLDS 1.0716
Lactobacillus sp. JCM 1552
Lactobacillus sp. KLDS 1.0717
Lactobacillus sp. JCM 1555
Lactobacillus sp. KLDS 1.0718
Lactobacillus sp. JCM 20043
Lactobacillus sp. KLDS 1.0719
Lactobacillus sp. JCM 20061
Lactobacillus sp. kvahm3N
Lactobacillus sp. JCM 2010
Lactobacillus sp. L-YJ
Lactobacillus sp. JCM 20147
Lactobacillus sp. L01
Lactobacillus sp. JCM 2048
Lactobacillus sp. L02
Lactobacillus sp. JCM 2049
Lactobacillus sp. L03
Lactobacillus sp. JCM 2761
Lactobacillus sp. LI
Lactobacillus sp. JCM 2762
Lactobacillus sp. L10
Lactobacillus sp. JCM 2763
Lactobacillus sp. LI 1
Lactobacillus sp. JCM 2764
Lactobacillus sp. L12
Lactobacillus sp. JCM 2768
Lactobacillus sp. LI3
Lactobacillus sp. JCM 2770
Lactobacillus sp. L13(2006)
Lactobacillus sp. JCM 2774
Lactobacillus sp. L14
Lactobacillus sp. JCM 5867
Lactobacillus sp. L15
Lactobacillus sp. JCM 5868
Lactobacillus sp. L17
Lactobacillus sp. JCM 5869
Lactobacillus sp. LI8
Lactobacillus sp. JCM 7524
Lactobacillus sp. L19
Lactobacillus sp. JCM 7525
Lactobacillus sp. L2
Lactobacillus sp. JCM 7527
Lactobacillus sp. L20
Lactobacillus sp. JCM 8601
Lactobacillus sp. L21
Lactobacillus sp. JCM 8609
Lactobacillus sp. L215
Lactobacillus sp. JCM 8616
Lactobacillus sp. L22
Lactobacillus sp. JCM 8633
Lactobacillus sp. L23
Lactobacillus sp. SR2
Lactobacillus sp. TBZ3
Lactobacillus sp. SW201
Lactobacillus sp. TFC 4301
Lactobacillus sp. SWM Isolation 3
Lactobacillus sp. THK-024
Lactobacillus sp. SXVIII10(2011)
Lactobacillus sp. THK-V2
Lactobacillus sp. SXVIII11(2011)
Lactobacillus sp. THK-V8
Lactobacillus sp. SXVIII9(2011)
Lactobacillus sp. THK-W28
Lactobacillus sp. T057
Lactobacillus sp. TIIK-W4
Lactobacillus sp. T059
Lactobacillus sp. Thmrol5
Lactobacillus sp. T11g2
Lactobacillus sp. Thmro2
Lactobacillus sp. T13/5
Lactobacillus sp. Thmro6
Lactobacillus sp. T17/4D
Lactobacillus sp. Thoto2
Lactobacillus sp. T17/4F
Lactobacillus sp. TL33a
Lactobacillus sp. T1R1C12
Lactobacillus sp. TL35
Lactobacillus sp. T1R2C3
Lactobacillus sp. TLMP1
Lactobacillus sp. T1R3C2
Lactobacillus sp. TLMP2
Lactobacillus sp. T23/3
Lactobacillus sp. TLMP3
Lactobacillus sp. T2R1C4
Lactobacillus sp. TLMP4
Lactobacillus sp. T2R2C12
Lactobacillus sp. TLMP5
Lactobacillus sp. T2R4C3
Lactobacillus sp. TMW 1.1309
Lactobacillus sp. T3R1C1
Lactobacillus sp. TNG 15
Lactobacillus sp. T3R2C12
Lactobacillus sp. TN627
Lactobacillus sp. T3R2C13
Lactobacillus sp. TN644
Lactobacillus sp. T4R2C14
Lactobacillus sp. Tporo2
Lactobacillus sp. T4R3C18
Lactobacillus sp. TR7.2.20
Lactobacillus sp. T5 R1C10
Lactobacillus sp. TR7.3.1 7
Lactobacillus sp. T5R3C15
Lactobacillus sp. TR7.4.12
Lactobacillus sp. T5R3C19
Lactobacillus sp. TRC1
Lactobacillus sp. T5R3C24
Lactobacillus sp. TRC7
Lactobacillus sp. T5R4C21
Lactobacillus sp. TRF5
Lactobacillus sp. TAB-OI
Lactobacillus sp. TRF7
Lactobacillus sp. TAB-02
Lactobacillus sp. TRF8
Lactobacillus sp. TAB-03
Lactobacillus sp. TS1
Lactobacillus sp. TAB-04
Lactobacillus sp. TS2
Lactobacillus sp. TAB-05
Lactobacillus sp. TS3
Lactobacillus sp. TAB-06
Lactobacillus sp. TS4
Lactobacillus sp. TAB-07
Lactobacillus sp. TSK G32-2
Lactobacillus sp. TAB-08
Lactobacillus sp. TTp12
Lactobacillus sp. TAB-09
Lactobacillus sp. TTp13
Lactobacillus sp. TAB-10
Lactobacillus sp. TTp14
Lactobacillus sp. TAB-11
Lactobacillus sp. TTp4
Lactobacillus sp. TAB-13
Lactobacillus sp. TTp6
Lactobacillus sp. TAB-15
Lactobacillus sp. V2
Lactobacillus sp. TAB-16
Lactobacillus sp. VITPRS49
Lactobacillus sp. TAB-19
Lactobacillus sp. VM9
Lactobacillus sp. TAB-20
Lactobacillus sp. W2
Lactobacillus sp. TAB-21
Lactobacillus sp. W20
Lactobacillus sp. TAB-22
Lactobacillus sp. W56
Lactobacillus sp. TAB-23
Lactobacillus sp. WC2
Lactobacillus sp. TAB-24
Lactobacillus sp. WDC04
Lactobacillus sp. TAB-25
Lactobacillus sp. WK2S-6B
Lactobacillus sp. TAB-26
Lactobacillus sp. WX131
Lactobacillus sp. TAB-29
Lactobacillus sp. WX212
Lactobacillus sp. TAB-30
Lactobacillus sp. WX213
Lactobacillus sp. TAB-31
Lactobacillus sp. XI
Lactobacillus sp. TAB-33
Lactobacillus sp. Y10
Lactobacillus sp. Taj Amir-1
Lactobacillus sp. Yazid Arash-1
Lactobacillus sp. Taj Mahdi
Lactobacillus sp. Yazid Taj-1
Lactobacillus sp. Taj Mar-1
Lactobacillus sp. YE06
Lactobacillus sp. Taj Mustafa-1
Lactobacillus sp. YE07
Lactobacillus sp. Taj Naser-1
Lactobacillus sp. YE08
Lactobacillus sp. Taj Yazid-1
Lactobacillus sp. YE 10
Lactobacillus sp. Taj-KH107
Lactobacillus sp. YFPB2BMX
Lactobacillus sp. Taj-KH109
Lactobacillus sp. YW
Lactobacillus sp. Taj-KH123
Lactobacillus sp. YYS
Lactobacillus sp. Taj-KS164
Lactobacillus sp. ZL7
Lactobacillus sp. Taj-KS82
Lactobacillus sp. ZYM7
Lactobacillus sp. Tajabadi-I
Lactobacillus sp. A A18
Lactobacillus sp. Tbbtol5
Lactobacillus sp. A A21
Lactobacillus sp. TBZ
Lactobacillus sp. A A25
Lactobacillus sp. TBZ2
Lactobacillus sp. A A29
Lactobacillus sp. A A3 5
Lactobacillus sp. r2
Lactobacillus sp. A A44
Lactobacillus sp. R4B
Lactobacillus sp. A A45
Lactobacillus sp. R4C
Lactobacillus sp. A A48
Lactobacillus sp. r5-wl0
Lactobacillus sp. A A49
Lactobacillus sp. r7
Lactobacillus sp. A A85
Lactobacillus sp. r8
Lactobacillus sp. A A96
Lactobacillus sp. RA2053
Lactobacillus sp. B A100
Lactobacillus sp. RA2062
Lactobacillus sp. B A101
Lactobacillus sp. RA2066
Lactobacillus sp. B A102
Lactobacillus sp. RA2113
Lactobacillus sp. B A103
Lactobacillus sp. RA2120
Lactobacillus sp. B A12
Lactobacillus sp. rennanqilfy 10
Lactobacillus sp. B A13
Lactobacillus sp. rennanqilfy 1 1
Lactobacillus sp. B A14
Lactobacillus sp. rennanqilfy 14
Lactobacillus sp. B A16
Lactobacillus sp. rennanqilfy 15
Lactobacillus sp. B A19
Lactobacillus sp. rennanqilfy 16
Lactobacillus sp. B A20
Lactobacillus sp. rennanqilfy 17
Lactobacillus sp. B A23
Lactobacillus sp. rennanqilfy 19
Lactobacillus sp. B A31
Lactobacillus sp. rennanqilfy 2
Lactobacillus sp. B A33
Lactobacillus sp. rennanqilfy20
Lactobacillus sp. NM59-6
Lactobacillus sp. rennanqilfy32
Lactobacillus sp. NR1006
Lactobacillus sp. rennanqilfy34
Lactobacillus sp. NRCT-KU 1
Lactobacillus sp. rennanqilfy61
Lactobacillus sp. NS 111
Lactobacillus sp. rennanqilyf 13
Lactobacillus sp. NS123
Lactobacillus sp. rennanqilyf4
Lactobacillus sp. NS133
Lactobacillus sp. rennanqilyf5
Lactobacillus sp. Oh-3
Lactobacillus sp. rennanqilyf7
Lactobacillus sp. Oh-4
Lactobacillus sp. rennanqilyfiS
Lactobacillus sp. OR 11
Lactobacillus sp. rennanqilyf?
Lactobacillus sp. OR 9
Lactobacillus sp. RIC11-BK004
Lactobacillus sp. OR1
Lactobacillus sp. RIC11-BK008
Lactobacillus sp. OR6
Lactobacillus sp. RIC11-BK009
Lactobacillus sp. oral taxon 052
Lactobacillus sp. RIC11-MK006
Lactobacillus sp. oral taxon 418
Lactobacillus sp. RIC11-MK010
Lactobacillus sp. oral taxon 424
Lactobacillus sp. RIC12-Oh002
Lactobacillus sp. oral taxon 461
Lactobacillus sp. RIC12-Oh004
Lactobacillus sp. oral taxon A89
Lactobacillus sp. RKY2
Lactobacillus sp. oral taxon B73
Lactobacillus sp. RMS3-1
Lactobacillus sp. oral taxon B80
Lactobacillus sp. Rnm4
Lactobacillus sp. oral taxon D06
Lactobacillus sp. Rrv5
Lactobacillus sp. oral taxon G15
Lactobacillus sp. RU1
Lactobacillus sp. oral taxon G16
Lactobacillus sp. SI
Lactobacillus sp. oral taxon G18
Lactobacillus sp. S14
Lactobacillus sp. oral taxon G19
Lactobacillus sp. SI5
Lactobacillus sp. oral taxon G98
Lactobacillus sp. S16
Lactobacillus sp. oral taxon H08
Lactobacillus sp. S19
Lactobacillus sp. oral taxon H12
Lactobacillus sp. S4-3
Lactobacillus sp. oral taxon H14
Lactobacillus sp. S4B
Lactobacillus sp. oral taxon H25
Lactobacillus sp. S4C
Lactobacillus sp. OS 10
Lactobacillus sp. Sal8
Lactobacillus sp. OS72
Lactobacillus sp. SCA34
Lactobacillus sp. P22
Lactobacillus sp. SCA39
Lactobacillus sp. P23
Lactobacillus sp. SCA52
Lactobacillus sp. P8
Lactobacillus sp. SCA7
Lactobacillus sp. PC-3
Lactobacillus sp. SD2
Lactobacillus sp. PC121B
Lactobacillus sp. SDR1
Lactobacillus sp. pep8
Lactobacillus sp. SH.Z4
Lactobacillus sp. Probio-24
Lactobacillus sp. sh.zhl
Lactobacillus sp. Probio-27
Lactobacillus sp. sfi.zh2
Lactobacillus sp. QOX-01BC
Lactobacillus sp. sh.zh3
Lactobacillus sp. QOX-02BC
Lactobacillus sp. Shuhaimi Arash-1
Lactobacillus sp. QOX-06BC
Lactobacillus sp. Shuhaimi Mardan-1
Lactobacillus sp. QOX-10BC
Lactobacillus sp. Shuhaimi naser-1
Lactobacillus sp. QOX-20G
Lactobacillus sp. Shuhaimi Taj-1
Lactobacillus sp. R-17510
Lactobacillus sp. Shuhaimi Yazid-1
Lactobacillus sp. R-17516
Lactobacillus sp. SK007
Lactobacillus sp. R-17818
Lactobacillus sp. SL
Lactobacillus sp. R-21386
Lactobacillus sp. SRI
Lactobacillus sp. R-42633
Lactobacillus sp. B AB1
Lactobacillus sp. rlw3
Lactobacillus sp. B CGI
Lactobacillus sp. B CG3
Lactobacillus sp. B A98
Lactobacillus sp. B CG53
Lactobacillus sp. B CG71
Lactobacillus sp. B CG63
Lactobacillus sp. B CG76
Lactobacillus sp. B A34
Lactobacillus sp. B A36
Lactobacillus amylovorus CAG:719
Lactobacillus sp. B A37
Lactobacillus mminis CAG:367
Lactobacillus sp. B A41
Lactobacillus sp. DGGE band 26
Lactobacillus sp. B A42
Lactobacillus sp. DGGE band 29
Lactobacillus sp. B A52
Lactobacillus sp. enrichment culture clone 1
Lactobacillus sp. B A53
Lactobacillus sp. enrichment culture clone 58
Lactobacillus sp. B A64
Lactobacillus sp. enrichment culture clone PSR03
Lactobacillus sp. B A65
Lactobacillus sp. enrichment culture clone PSR2
Lactobacillus sp. B A76
Lactobacillus sp. enrichment culture clone PTmrs6
Lactobacillus sp. B A78
Lactobacillus sp. enrichment culture DGGE gel band 10
Lactobacillus sp. B A81
Lactobacillus sp. enrichment culture DGGE gel band 12
Lactobacillus sp. B A86
Lactobacillus sp. enrichment culture DGGE gel band 4
Lactobacillus sp. B A87
Lactobacillus sp. enrichment culture DGGE gel band 8
Lactobacillus sp. B A89
Lactobacillus sp. enrichment culture DGGE gel band 9
Lactobacillus sp. B A90
Lactobacillus sp. oral clone CX036
Lactobacillus sp. B A91
Lactobacillus sp. oral clone HT002
Lactobacillus sp. B A95
Lactobacillus sp. B A97
Bifidobacterium adolescentis
Bifidobacterium breve EX336960VC18
Bifidobacterium adolescentis ATCC′ 15703
Bifidobacterium breve EX336960VC19
Bifidobacterium adolescentis L2-32
Bifidobacterium breve EX336960VC21
Bifidobacterium angulatum
Bifidobacterium breve EX533959VC21
Bifidobacterium angulatum DSM 20098 = JCM 7096
Bifidobacterium breve HPH0326
Bifidobacterium angulatum F16 22
Bifidobacterium breve JCP7499
Bifidobacterium animalis
Bifidobacterium breve S27
Bifidobacterium animalis subsp. animalis
Bifidobacterium breve UCC2003
Bifidobacterium animalis subsp. animalis ATCC 25527
Bifidobacterium callitrichos
Bifidobacterium animalis subsp. lactis
Bifidobacterium catenulatum
Bifidobacterium animalis subsp. lactis AD011
Bifidobacterium catenulatum DSM 16992 = JCM 1194
Bifidobacterium animalis subsp. lactis ATCC 27673
Bifidobacterium chocrinum
Bifidobacterium animalis subsp. lactis B420
Bifidobacterium choerinum DSM 20434
Bifidobacterium animalis subsp. lactis BB-12
Bifidobacterium coryneforme
Bifidobacterium animalis subsp. lactis Bi-07
Bifidobacterium crudilactis
Bifidobacterium animalis subsp. lactis Bl-04
Bifidobacterium cuniculi
Bifidobacterium animalis subsp. lactis B112
Bifidobacterium dentium
Bifidobacterium animalis subsp. lactis BLC1
Bifidobacterium dentium ATCC 27678
Bifidobacterium animalis subsp. lactis BS 01
Bifidobacterium dentium ATCC 27679
Bifidobacterium animalis subsp. lactis CNCM 1-2494
Bifidobacterium dentium Bd 1
Bifidobacterium animalis subsp. lactis DSM 10140
Bifidobacterium dentium JCM 1195
Bifidobacterium animalis subsp. lactis HN019
Bifidobacterium dentium JCVTHMP022
Bifidobacterium animalis subsp. lactis V9
Bifidobacterium gallicum
Bifidobacterium asteroides
Bifidobacterium gallicum DSM 20093
Bifidobacterium asteroides PRL2011
Bifidobacterium gallinarum
Bifidobacterium biavatii
Bifidobacterium indicum
Bifidobacterium bifidum
Bifidobacterium bifidum ATCC 29521 - JCM 1255
Bifidobacterium indicum LMG 11587
Bifidobacterium bifidum BGN4
Bifidobacterium kashiwanohense
Bifidobacterium bifidum CECT 7366
Bifidobacterium kashiwanohense JCM 15439
Bifidobacterium bifidum DSM 20215
Bifidobacterium longum
Bifidobacterium bifidum IPLA 20015
Bifidobacterium longum 3 1 37DFAAB
Bifidobacterium bifidum JCM 1254
Bifidobacterium longum AGR2137
Bifidobacterium bifidum LMG 13195
Bifidobacterium longum BORI
Bifidobacterium bifidum NCI MB 41171
Bifidobacterium longum D2957
Bifidobacterium bifidum PRL2010
Bifidobacterium longum DJO10A
Bifidobacterium bifidum S17
Bifidobacterium longum El 8
Bifidobacterium bombi
Bifidobacterium longum NCC2705
Bifidobacterium bombi DSM 19703
Bifidobacterium longum subsp. infantis
Bifidobacterium bourn
Bifidobacterium longum subsp. infantis 157F
Bifidobacterium breve
Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222
Bifidobacterium breve ACS-071 -V-Sch8b
Bifidobacterium longum subsp. infantis CCUG 52486
Bifidobacterium breve CECT 7263
Bifidobacterium longum subsp. longum
Bifidobacterium breve DPC 6330
Bifidobacterium longum subsp. longum 1-5B
Bifidobacterium breve DSM 20213 = JCM 1192
Bifidobacterium longum subsp. longum 1-6B
Bifidobacterium longum subsp. longum 17-1B
Bifidobacterium sp. 234
Bifidobacterium longum subsp. longum 2-2B
Bifidobacterium sp. 265
Bifidobacterium longum subsp. longum 35B
Bifidobacterium sp. 266
Bifidobacterium longum subsp. longum 44B
Bifidobacterium sp. 27
Bifidobacterium longum subsp. longum 7-IB
Bifidobacterium sp. 272
Bifidobacterium longum subsp. longum ATCC 55813
Bifidobacterium sp. 283
Bifidobacterium longum subsp. longum BBMN68
Bifidobacterium sp. 286
Bifidobacterium longum subsp. longum CECT 7347
Bifidobacterium sp. 316
Bifidobacterium longum subsp. longum CMCC P0001
Bifidobacterium sp. 320
Bifidobacterium longum subsp. longum F8
Bifidobacterium sp. 323
Bifidobacterium longum subsp. longum GT15
Bifidobacterium sp. 33
Bifidobacterium longum subsp. longum JCM 1217
Bifidobacterium sp. 343
Bifidobacterium longum subsp. longum JDM301
Bifidobacterium sp. 344
Bifidobacterium longum subsp. longum KACC 91563
Bifidobacterium sp. 360
Bifidobacterium longum subsp. suis
Bifidobacterium sp. 397
Bifidobacterium magnum
Bifidobacterium sp. 401
Bifidobacterium magnum DSM 20222
Bifidobacterium sp. 434
Bifidobacterium merycicum
Bifidobacterium sp. 445
Bifidobacterium minimum
Bifidobacterium sp. 470
Bifidobacterium minimum DSM 20102
Bifidobacterium sp. 471
Bifidobacterium mongoliense
Bifidobacterium sp. 65947
Bifidobacterium pseudocatenulatum
Bifidobacterium sp. 69
Bifidobacterium pseudocatenulatum D2CA
Bifidobacterium sp. 7101
Bifidobacterium pseudocatenulatum DSM 20438 - JCM 1200
Bifidobacterium sp. 77
Bifidobacterium pseudolongum
Bifidobacterium sp. 84
Bifidobacterium pseudolongum AGR2145
Bifidobacterium sp. 98
Bifidobacterium pseudolongum subsp. globosum
Bifidobacterium sp. Al
Bifidobacterium pseudolongum subsp. pseudolongum
Bifidobacterium sp. Al 1
Bifidobacterium psychraerophilum
Bifidobacterium sp. Al 5
Bifidobacterium pullorum
Bifidobacterium sp. A24
Bifidobacterium pullorum ATCC 49618
Bifidobacterium sp. A30
Bifidobacterium reuteri
Bifidobacterium sp. Aabbtol9
Bifidobacterium ruminantium
Bifidobacterium sp. Aahmro6
Bifidobacterium saeculare
Bifidobacterium sp. Aahmto9
Bifidobacterium saguini
Bifidobacterium sp. Acbbto5
Bifidobacterium scardovii
Bifidobacterium sp. Achmrol 1
Bifidobacterium scardovii JCM 12489
Bifidobacterium sp. AcjBFl
Bifidobacterium simiae
Bifidobacterium sp. AcjBFlO
Bifidobacterium stellenboschense
Bifidobacterium sp. AcjBFl 1
Bifidobacterium stercoris
Bifidobacterium sp. AcjBF2
Bifidobacterium subtile
Bifidobacterium sp. AcjBF3
Bifidobacterium subtile DSM 20096
Bifidobacterium sp. AcjBF4
Bifidobacterium thermaeidophilum
Bifidobacterium sp. AcjBF5
Bifidobacterium thermacidophilum subsp. porcinum
Bifidobacterium sp. AcjBF6
Bifidobacterium thermacidophilum subsp. thermacidophilum
Bifidobacterium sp. AcjBF7
Bifidobacterium thermacidophilum subsp. thermacidophilum DSM
Bifidobacterium sp. AcjBF8
Bifidobacterium sp. AcjBF9
Bifidobacterium thcrmophilum
Bifidobacterium sp. Adhmto 10
Bifidobacterium Ihermophilum RBL67
Bifidobacterium sp. AFB22-4
Bifidobacterium tsurumiense
Bifidobacterium sp. Afporl 1
Bifidobacterium tsurumiense DSM 17777
Bifidobacterium sp. Afpor3
Bifidobacterium sp.
Bifidobacterium sp. Afpotol9
Bifidobacterium sp. 103
Bifidobacterium sp. AGR2158
Bifidobacterium sp. 108
Bifidobacterium sp. Alhonro l
Bifidobacterium sp. 11-5-G
Bifidobacterium sp. Ammopor6
Bifidobacterium sp. 113
Bifidobacterium sp. Ammpo1R4
Bifidobacterium sp. 120
Bifidobacterium sp. AmsbbiTO
Bifidobacterium sp. 126
Bifidobacterium sp. Amsbbt12
Bifidobacterium sp. 129
Bifidobacterium sp. Amshmr9
Bifidobacterium sp. 12147BFAA
Bifidobacterium sp. Amshor11
Bifidobacterium sp. 138
Bifidobacterium sp. Anbbr2
Bifidobacterium sp. 150
Bifidobacterium sp. Anuhmto12
Bifidobacterium sp. 17
Bifidobacterium sp. B4
Bifidobacterium sp. 172
Bifidobacterium sp. BBDP69
Bifidobacterium sp. 176
Bifidobacterium sp. BcRW10
Bifidobacterium sp. 182
Bifidobacterium sp. Bin2
Bifidobacterium sp. 197
Bifidobacterium sp. Bin7
Bifidobacterium sp. 202
Bifidobacterium sp. Bisn6
Bifidobacterium sp. 215
Bifidobacterium sp. Bma6
Bifidobacterium sp. 216
Bifidobacterium sp. CB38
Bifidobacterium sp. CB8
Bifidobacterium sp. M45
Bifidobacterium sp. CFAR 172
Bifidobacterium sp. M7
Bifidobacterium sp. CJ59
Bifidobacterium sp. Mbobb2r3
Bifidobacterium sp. CJ75
Bifidobacterium sp. Mbobb2t2
Bifidobacterium sp. CS16
Bifidobacterium sp. Mbpor2
Bifidobacterium sp. CS2
Bifidobacterium sp. MSTE12
Bifidobacterium sp. CS30
Bifidobacterium sp. MSX5B
Bifidobacterium sp. CWCAST32
Bifidobacterium sp. MW-222
Bifidobacterium sp. CWCAST40
Bifidobacterium sp. MW-613
Bifidobacterium sp. CWSAB40
Bifidobacterium sp. MW-623
Bifidobacterium sp. CWSAB6
Bifidobacterium sp. MW-81
Bifidobacterium sp. DJF_RP64kl
Bifidobacterium sp. N33
Bifidobacterium sp. DJF WC44
Bifidobacterium sp. oral strain A32ED
Bifidobacterium sp. DPTE6
Bifidobacterium sp. oral strain H6-M4
Bifidobacterium sp. DPVI-TET3
Bifidobacterium sp. PB24
Bifidobacterium sp. DPVI-TET6
Bifidobacterium sp. PEB0163
Bifidobacterium sp. F-10
Bifidobacterium sp. PFGE 14
Bifidobacterium sp. F-ll
Bifidobacterium sp. PFGE 18
Bifidobacterium sp. F2
Bifidobacterium sp. PFGE 8
Bifidobacterium sp. F8
Bifidobacterium sp. PFGE 9a
Bifidobacterium sp. G29
Bifidobacterium sp. PG10
Bifidobacterium sp. GC61
Bifidobacterium sp. PG12A
Bifidobacterium sp. group 1-3
Bifidobacterium sp. PG12B
Bifidobacterium sp. group II-3
Bifidobacterium sp. PG13
Bifidobacterium sp. group TII-3
Bifidobacterium sp. PG1 5
Bifidobacterium sp. hl2
Bifidobacterium sp. PG18
Bifidobacterium sp. HGAT1
Bifidobacterium sp. PG19
Bifidobacterium sp. HGAT10
Bifidobacterium sp. PG2
Bifidobacterium sp. HGAT2
Bifidobacterium sp. PG22
Bifidobacterium sp. HGAT3
Bifidobacterium sp. PG30
Bifidobacterium sp. HGAT4
Bifidobacterium sp. PG9
Bifidobacterium sp. HGAT5
Bifidobacterium sp. PL1
Bifidobacterium sp. HGAT6
Bifidobacterium sp. S-10
Bifidobacterium sp. HGAT7
Bifidobacterium sp. S13-05
Bifidobacterium sp. HGAT8
Bifidobacterium sp. S18-11
Bifidobacterium sp. HGAT9
Bifidobacterium sp. SLPYG-1
Bifidobacterium sp. Hma3
Bifidobacterium sp. SMst02
Bifidobacterium sp. HMLN1
Bifidobacterium sp. SRW-001
Bifidobacterium sp. HMLN12
Bifidobacterium sp. SRW-002
Bifidobacterium sp. HMLN13
Bifidobacterium sp. SRW-003
Bifidobacterium sp. HMLN14
Bifidobacterium sp. SRW-004
Bifidobacterium sp. HMLN5
Bifidobacterium sp. Tbbto10
Bifidobacterium sp. HMLN8
Bifidobacterium sp. Thsr10
Bifidobacterium sp. HMSFfl
Bifidobacterium sp. Thsr18
Bifidobacterium sp. HMSH2
Bifidobacterium sp. Thsr2
Bifidobacterium sp. HMSH5
Bifidobacterium sp. TM-7
Bifidobacterium sp. IR007-108
Bifidobacterium sp. Trm9
Bifidobacterium sp. IR007-113
Bifidobacterium sp. IR007-15
Bifidobacterium adolescentis CAG:119
Bifidobacterium sp. IR007-57
Bifidobacterium bifidum CAG:234
Bifidobacterium sp. IR007-93
Bifidobacterium longum CAG:69
Bifidobacterium sp. IR007-94
Bifidobacterium pscudocatcnulatum CAG:263
Bifidobacterium sp. IS03519
Bifidobacterium sp. enrichment culture DGGE gel band 6
Bifidobacterium sp. JCM 6439
Bifidobacterium sp. enrichment culture DGGE gel band 7
Bifidobacterium sp. JCM 7013
Bifidobacterium sp. oral clone 5RH-30
Bifidobacterium sp. JCM 7022
Bifidobacterium sp. oral clone CX010
Bifidobacterium sp. JCM 7023
Bifidobacterium sp. JCM 7027
Bifidobacterium sp. JCM 7028
Bifidobacterium sp. JCM 7042
Bifidobacterium sp. JEMLUCVII-1
Bifidobacterium sp. JEMLUCVIII-4
Bifidobacterium sp. LISLUCII-P2
Bifidobacterium sp. LISLUCIII-2
Bifidobacterium sp. LISLUCIII-P2
Bifidobacterium sp. LISPASI-P3
Bifidobacterium sp. LLS001
Bifidobacterium sp. LUCL-P3
Bifidobacterium sp. LUCL-W4
Bifidobacterium sp. M24
Lactobacillus acidophilus
This application is a continuation of U.S. application Ser. No. 14/428,341, filed Mar. 13, 2015, which is a United States National Stage filing under 35 U.S.C. § 371 of International PCT Application Serial No. PCT/US2013/059832, filed Sep. 13, 2013, that claims priority to U.S. Provisional Application Ser. No. 61/700,663, filed Sep. 13, 2012, entitled “Programmable Drug Delivery Profiles Of Tumor-Targeted Bacteria, each of which is incorporated herein by reference in its entirety.
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| Number | Date | Country | |
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| 20190078050 A1 | Mar 2019 | US |
| Number | Date | Country | |
|---|---|---|---|
| 61700663 | Sep 2012 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 14428341 | US | |
| Child | 16005390 | US |
