Patent Grant
12066017
The present invention relates to a cassette for pumping fluid.
In accordance with one aspect of the pumping cassette, the cassette is a cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.
Various embodiments of this aspect of the cassette include one or more of the following. Where the reciprocating pressure displacement pumps includes a curved rigid chamber wall and a flexible membrane attached to the rigid chamber wall. The flexible membrane and the rigid chamber wall define a pumping chamber. Also, where the cassette housing includes a top plate, midplate and a bottom plate. Also, where the cassette further includes a metering pump within the housing. The metering pump is fluidly connected to a fluid line and pumps a volume of a fluid. Also, where the pressure pump and the metering pump are pneumatically actuated pumps. Also, where the metering pump pumps a volume of a fluid such that the fluid bypasses the balancing chambers and the metering pump is a membrane pump. Also, where the cassette includes at least one fluid valve. Also, where the cassette includes at least two fluid valves actuated by one pneumatic valve.
In accordance with another aspect of the cassette is a cassette including a housing that includes at least one inlet fluid line and at least one outlet fluid line. The cassette also includes at least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod includes a membrane wherein the membrane forms two chambers within the balancing pod. Also included in the cassette is at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A metering pump is also included within the housing. The metering pump is fluidly connected to a fluid line. The metering pump pumps a predetermined volume of a fluid such that the fluid bypasses the balancing chambers and wherein the metering pump is a membrane pump.
Various embodiments of this aspect of the cassette include one or more of the following. Where the reciprocating pressure displacement pumps includes a curved rigid chamber wall and a flexible membrane attached to the rigid chamber wall. The flexible membrane and the rigid chamber wall define a pumping chamber. Also, where the cassette housing includes a top plate, a midplate and a bottom plate. Also, where the cassette further includes a at least one fluid valve, and/or where the fluid valve is actuated by one pneumatic valve. Also, where the cassette includes at least two fluid valves actuated by one pneumatic valve.
In accordance with another aspect of the pumping cassette, the pumping cassette includes a housing that includes at least two inlet fluid lines and at least two outlet fluid lines. Also, at least two balancing pods within the housing and in fluid connection with the fluid lines. The balancing pods balance the flow of pure dialysate and impure dialysate such that the volume of pure dialysate equals the volume of impure dialysate. At least two reciprocating pressure displacement membrane pumps are also included in the housing. The pressure pumps pump the pure dialysate and said impure dialysate. A UF metering pump is also included within the housing. The UF metering pump pumps a predetermined volume of impure dialysate from the at least one fluid line such that the predetermined volume bypasses said balancing chamber.
Various embodiments of this aspect of the cassette include one or more of the following. Where the reciprocating pressure displacement pumps includes a curved rigid chamber wall and a flexible membrane attached to the rigid chamber wall. The flexible membrane and the rigid chamber wall define a pumping chamber. Also, where the cassette housing includes a top plate, a midplate and a bottom plate. Also, a plurality of pneumatically actuated fluid valves.
These aspects of the invention are not meant to be exclusive and other features, aspects, and advantages of the present invention will be readily apparent to those of ordinary skill in the art when read in conjunction with the appended claims and accompanying drawings.
These and other features and advantages of the present invention will be better understood by reading the following detailed description, taken together with the drawings wherein:
1. Pumping Cassette
1.1 Cassette
The pumping cassette include various features, namely, pod pumps, fluid lines and in some embodiment, valves. The cassette embodiments shown and described in this description include exemplary and some alternate embodiments. However, any variety of cassettes having a similar functionality is contemplated.
As well, although the cassette embodiments described herein are implementations of the fluid schematics as shown in
In the exemplary embodiment, the cassette includes a top plate, a midplate and a bottom plate. There are a variety of embodiments for each plate. In general, the top plate includes pump chambers and fluid lines, the midplate includes complementary fluid lines, metering pumps and valves and the bottom plate includes actuation chambers (and in some embodiments, the top plate and the bottom plate include complementary portions of a balancing chamber).
In general, the membranes are located between the midplate and the bottom plate. However, with respect to balancing chambers, a portion of a membrane is located between the midplate and the top plate. Some embodiments include where the membrane is attached to the cassette, either overmolded, captured, bonded, press fit, welded in or any other process or method for attachment. However, in the exemplary embodiments, the membranes are separate from the top plate, midplate and bottom plate until the plates are assembled.
The cassettes may be constructed of a variety of materials. Generally, in the various embodiments, the materials used are solid and non flexible. In the preferred embodiment, the plates are constructed of polysulfone, but in other embodiments, the cassettes are constructed of any other solid material, and in exemplary embodiments, of any thermoplastic or thermosot. In some embodiments the cassettes are constructed of polycarbonate.
In the exemplary embodiment, the cassettes are formed by placing the membranes in their correct locations, assembling the plates in order, and connecting the plates. In one embodiment, the plates are connected using a laser welding technique. However, in other embodiments, the plates may be glued, mechanically fastened, strapped together, ultrasonically welded, or any other mode of attaching the plates together.
In practice, the cassette may be used to pump any type of fluid from any source to any location. The types of fluid include nutritive, nonnutritive, inorganic chemicals, organic chemicals, bodily fluids or any other type of fluid. Additionally, fluid in some embodiments include a gas. Thus, in some embodiments, the cassette is used to pump a gas.
The cassette serves to pump and direct the fluid from and to the desired locations. In some embodiments, outside pumps pump the fluid into the cassette and the cassette pumps the fluid out. However, in some embodiments, the pod pumps serve to pull the fluid into the cassette and pump the fluid out of the cassette.
As discussed above, depending on the valve locations, control of the fluid paths is imparted. Thus, the valves being in different locations or additional valves are alternate embodiments of this cassette. Additionally, the fluid lines and paths shown in the figures described above are mere examples of fluid lines and paths. Other embodiments may have more, less and/or different fluid paths. In still other embodiments, valves are not present in the cassette.
The number of pod pumps described above may also vary depending on the embodiment. For example, although the exemplary and alternate embodiments shown and described above include two pod pumps, in other embodiments, the cassette includes one. In still other embodiments, the cassette includes more than two pod pumps. The pod pumps can be single pumps or work in tandem to provide a more continuous flow. Either or both may be used in various embodiments of the cassette.
The various fluid inlets and fluid outlets are fluid ports. In practice, depending on the valve arrangement and control, a fluid inlet can be a fluid outlet. Thus, the designation of the fluid port as a fluid inlet or a fluid outlet is only for description purposes. The various embodiments have interchangeable fluid ports. The fluid ports are provided to impart particular fluid paths onto the cassette. These fluid ports are not necessarily all used all of the time; instead, the variety of fluid ports provides flexibility of use of the cassette in practice.
1.2 Exemplary Pressure Pod Pump Embodiments
A membrane 112 separates the central cavity of the pod pump into two chambers. In one embodiment, these chambers are: the pumping chamber that receives the fluid to be pumped, and an actuation chamber for receiving the control gas that pneumatically actuates the pump. An inlet 102 allows fluid to enter the pumping chamber, and an outlet 104 allows fluid to exit the pumping chamber. The inlet 102 and the outlet 104 may be formed between midplate 108 and the top plate 106. Pneumatic pressure is provided through a pneumatic port 114 to either force, with positive gas pressure, the membrane 112 against one wall of pod pump cavity to minimize the pumping chamber's volume, or to draw, with negative gas pressure, the membrane 112 towards the other wall of the pod pump 100 cavity to maximize the pumping chamber's volume.
The membrane 112 is provided with a thickened rim 116, which is held tightly by a protrusion 118 in the midplate 108. Thus, in manufacture, the membrane 112 can be placed in and held by the groove 108 before the bottom plate 110 is connected (in the exemplary embodiment) to the midplate 108.
Although not shown in
Referring first to
During typical fluid pumping operations, the application of negative or vent to atmosphere pneumatic pressure to the actuation or pneumatic interface 114 tends to withdraw the membrane 112 toward the actuation chamber wall 120 so as to expand the pumping/liquid chamber and draw fluid into the pumping chamber through the inlet 102, while the application of positive pneumatic pressure tends to push the membrane 112 toward the pumping chamber wall 122 so as to collapse the pumping chamber and expel fluid in the pumping chamber through the outlet 104. During such pumping operations, the interior surfaces of the pumping chamber wall 122 and the actuation chamber wall 120 limit movement of the membrane 112 as it reciprocates back and forth. In the embodiment shown in
Thus, in the embodiment shown in
In an exemplary embodiment, the pumping chamber wall 122 and the actuation chamber wall 120 both have a hemispheroid shape so that the pumping chamber will have a spheroid shape when it is at its maximum volume. By using a pumping chamber that attains a spheroid shape—and particularly a spherical shape—at maximum volume, circulating flow may be attained throughout the pumping chamber. Such shapes accordingly tend to avoid stagnant pockets of fluid in the pumping chamber. As discussed further below, the orientations of the inlet 102 and outlet 104 also tend to have an impact on the flow of fluid through the pumping chamber and in some embodiments, reduce the likelihood of stagnant pockets of fluid forming. Additionally, compared to other volumetric shapes, the spherical shape (and spheroid shapes in general) tends to create less shear and turbulence as the fluid circulates into, through, and out of the pumping chamber.
Referring now to
1.3 Exemplary Balancing Pods Embodiment
Referring now to
The membrane 112 provides a seal between the two chambers. The balancing chambers work to balance the flow of fluid into and out of the chambers such that both chambers maintain an equal volume rate flow. Although the inlets 102 and outlets 104 for each chamber are shown to be on the same side, in other embodiments, the inlets 102 and outlets 104 for each chamber are on different sides. Also, the inlets 102 and outlets 104 can be on either side, depending on the flow path in which the balancing chamber is integrated.
In one embodiment of the balancing chambers the membrane 112 includes an embodiment similar to the one described below with respect to
1.4 Metering Pumps and Fluid Management System
The metering pump can be any pump that is capable of adding any fluid or removing any fluid. The fluids include but are not limited to pharmaceuticals, inorganic compounds or elements, organic compounds or elements, nutraceuticals, nutritional elements or compounds or solutions, or any other fluid capable of being pumped. In one embodiment, the metering pump is a membrane pump. In the exemplary embodiment, the metering pump is a smaller volume pod pump. In the exemplary embodiment, the metering pump includes an inlet and an outlet, similar to a larger pod pump (as shown in
Thus, depending on the embodiment, this volume of fluid that has been removed will not then flow to the fluid outlet, the balance chambers or to a pod pump. Thus, in some embodiments, the metering pump is used to remove a volume of fluid from a fluid line. In other embodiments, the metering pump is used to remove a volume of fluid to produce other results.
FMS may be used to perform certain fluid management system measurements, such as, for example, measuring the volume of subject fluid pumped through the pump chamber during a stroke of the membrane or detecting air in the pumping chamber, e.g., using techniques described in U.S. Pat. Nos. 4,808,161; 4,826,482; 4,976,162; 5,088,515; and 5,350,357, which are hereby incorporated herein by reference in their entireties.
Metering pumps are also used in various embodiments to pump a second fluid into the fluid line. In some embodiments, the metering pump is used to pump a therapeutic or a compound into a fluid line. One embodiment uses the metering pump to pump a volume of compound into a mixing chamber in order to constitute a solution. In some of these embodiments, the metering pumps are configured for FMS volume measurement. In other embodiments, the metering pumps are not.
For FMS measurement, a small fixed reference air chamber is located outside of the cassette, for example, in the pneumatic manifold (not shown). A valve isolates the reference chamber and a second pressure sensor. The stroke volume of the metering pump may be precisely computed by charging the reference chamber with air, measuring the pressure, and then opening the valve to the pumping chamber. The volume of air on the chamber side may be computed based on the fixed volume of the reference chamber and the change in pressure when the reference chamber was connected to the pump chamber.
1.5 Valves
The exemplary embodiment of the cassette includes one or more valves. Valves are used to regulate flow by opening and closing fluid lines. The valves included in the various embodiments of the cassette include one or more of the following: volcano valves or smooth valves. In some embodiments of the cassette, check valves may be included. Embodiments of the volcano valve are shown in
Generally speaking, reciprocating positive-displacement pumps of the types just described may include, or may be used in conjunction with, various valves to control fluid flow through the pump. Thus, for example, the reciprocating positive-displacement pump or the balancing pods may include, or be used in conjunction with, an inlet valve and/or an outlet valve. The valves may be passive or active. In the exemplary embodiment of the reciprocating positive-displacement pump the membrane is urged back and forth by positive and negative pressurizations, or by positive and vent to atmosphere pressurizations, of a gas provided through the pneumatic port, which connects the actuation chamber to a pressure actuation system. The resulting reciprocating action of the membrane pulls fluid into the pumping chamber from the inlet (the outlet valve prevents liquid from being sucked back into the pumping chamber from the outlet) and then pushes the fluid out of the pumping chamber through the outlet (the inlet valve prevents fluid from being forced back from the inlet).
In the exemplary embodiments, active valves control the fluid flow through the pump(s) and the cassette. The active valves may be actuated by a controller in such a manner as to direct flow in a desired direction. Such an arrangement would generally permit the controller to cause flow in either direction through the pod pump. In a typical system, the flow would normally be in a first direction, e.g., from the inlet to the outlet. At certain other times, the flow may be directed in the opposite direction, e.g., from the outlet to the inlet. Such reversal of flow may be employed, for example, during priming of the pump, to check for an aberrant line condition (e.g., a line occlusion, blockage, disconnect, or leak), or to clear an aberrant line condition (e.g., to try to dislodge a blockage).
Pneumatic actuation of valves provides pressure control and a natural limit to the maximum pressure that may be developed in a system. In the context of a system, pneumatic actuation has the added benefit of providing the opportunity to locate all the solenoid control valves on one side of the system away from the fluid paths.
Referring now to
The pneumatic port 208 is defined by a channel formed in the top plate 214. By providing pneumatic control of several valves in a cassette, valves can be ganged together so that all the valves ganged together can be opened or closed at the same time by a single source of pneumatic pressure. Channels formed on the midplate 204, corresponding with fluid paths along with the bottom plate 216, define the valve inlet 218 and the valve outlet 220. Holes formed through the midplate 204 provide communication between the inlet 218 and the valving chamber 206 and between the valving chamber 206 and the outlet 220.
The membrane 202 is provided with a thickened rim 222, which fits tightly in a groove 224 in the midplate 204. Thus, the membrane 202 can be placed in and held by the groove 224 before the top plate 214 is connected to the midplate 204. Thus, this valve design may impart benefits in manufacture. As shown in
1.6 Exemplary Embodiments of the Pod Membrane
In some embodiments, the membrane has a variable cross-sectional thickness, as shown in
Referring now to
The membrane may be made of any flexible material having a desired durability and compatibility with the subject fluid. The membrane can be made from any material that may flex in response to fluid, liquid or gas pressure or vacuum applied to the actuation chamber. The membrane material may also be chosen for particular bio-compatibility, temperature compatibility or compatibility with various subject fluids that may be pumped by the membrane or introduced to the chambers to facilitate movement of the membrane. In the exemplary embodiment, the membrane is made from high elongation silicone. However, in other embodiments, the membrane is made from any elastomer or rubber, including, but not limited to, silicone, urethane, nitrile, EPDM or any other rubber, elastomer or flexible material.
The shape of the membrane is dependent on multiple variables. These variables include, but are not limited to: the shape of the chamber; the size of the chamber; the subject fluid characteristics; the volume of subject fluid pumped per stroke; and the means or mode of attachment of the membrane to the housing. The size of the membrane is dependent on multiple variables. These variables include, but are not limited to: the shape of the chamber; the size of the chamber; the subject fluid characteristics; the volume of subject fluid pumped per stroke; and the means or mode of attachment of the membrane to the housing. Thus, depending on these or other variables, the shape and size of the membrane may vary in various embodiments.
The membrane can have any thickness. However, in some embodiments, the range of thickness is between 0.002 inches to 0.125 inches. Depending on the material used for the membrane, the desired thickness may vary. In one embodiment, high elongation silicone is used in a thickness ranging from 0.015 inches to 0.050 inches. However, in other embodiments, the thickness may vary.
In the exemplary embodiment, the membrane is preformed to include a substantially dome shape in at least part of the area of the membrane. One embodiment of the dome-shaped membrane is shown in
In the exemplary embodiment, the membrane dome is formed using liquid injection molding. However, in other embodiments, the dome may be formed by using compression molding. In alternate embodiments, the membrane is substantially flat. In other embodiments, the dome size, width, or height may vary.
In various embodiments, the membrane may be held in place by various means and methods. In one embodiment, the membrane is clamped between the portions of the cassette, and in some of these embodiments, the rim of the cassette may include features to grab the membrane. In others of this embodiment, the membrane is clamped to the cassette using at least one bolt or another device. In another embodiment, the membrane is over-molded with a piece of plastic and then the plastic is welded or otherwise attached to the cassette. In another embodiment, the membrane is pinched between the mid plate described with respect to
In some embodiments of the gasket, the gasket is contiguous with the membrane. However, in other embodiments, the gasket is a separate part of the membrane. In some embodiments, the gasket is made from the same material as the membrane. However, in other embodiments, the gasket is made of a material different from the membrane. In some embodiments, the gasket is formed by over-molding a ring around the membrane. The gasket can be any shape ring or seal desired so as to complement the pod pump housing embodiment. In some embodiments, the gasket is a compression type gasket.
1.7 Mixing Pods
Some embodiments of the cassette include a mixing pod. A mixing pod includes a chamber for mixing. In some embodiments, the mixing pod is a flexible structure, and in some embodiments, at least a section of the mixing pod is a flexible structure. The mixing pod can include a seal, such as an o-ring, or a membrane. The mixing pod can be any shape desired. In the exemplary embodiment, the mixing pod is similar to a pod pump except it does not include a membrane and does not include an actuation port. Some embodiments of this embodiment of the mixing pod include an o-ring seal to seal the mixing pod chamber. Thus, in the exemplary embodiment, the mixing pod is a spherical hollow pod with a fluid inlet and a fluid outlet. As with the pod pumps, the chamber size can be any size desired.
2. Pressure Pump Actuation System
The positive-pressure reservoir provides to the actuation chamber the positive pressurization of a control gas to urge the membrane towards a position where the pumping chamber is at its minimum volume (i.e., the position where the membrane is against the rigid pumping-chamber wall). The negative-pressure reservoir provides to the actuation chamber the negative pressurization of the control gas to urge the membrane in the opposite direction, towards a position where the pumping chamber is at its maximum volume (i.e., the position where the membrane is against the rigid actuation-chamber wall).
A valving mechanism is used to control fluid communication between each of these reservoirs and the actuation chamber. As shown in
The controller also receives pressure information from the three pressure transducers: an actuation-chamber pressure transducer, a positive-pressure-reservoir pressure transducer, and a negative-pressure-reservoir pressure transducer. As their names suggest, these transducers respectively measure the pressure in the actuation chamber, the positive-pressure reservoir, and the negative-pressure reservoir. The actuation-chamber-pressure transducer is located in a base unit but is in fluid communication with the actuation chamber through the pod pump pneumatic port. The controller monitors the pressure in the two reservoirs to ensure they are properly pressurized (either positively or negatively). In one exemplary embodiment, the positive-pressure reservoir may be maintained at around 750 mmHg, while the negative-pressure reservoir may be maintained at around −450 mmHg.
Still referring to
The pressure provided by the positive-pressure reservoir is preferably strong enough— under normal conditions— to urge the membrane all the way against the rigid pumping-chamber wall. Similarly, the negative pressure (i.e., the vacuum) provided by the negative-pressure reservoir is preferably strong enough— under normal conditions to urge the membrane all the way against the actuation-chamber wall. In a further preferred embodiment, however, these positive and negative pressures provided by the reservoirs are within safe enough limits that even with either the positive-supply valve or the negative-supply valve open all the way, the positive or negative pressure applied against the membrane is not so strong as to damage the pod pump or create unsafe fluid pressures (e.g., that may harm a patient receiving pumped blood or other fluid).
It will be appreciated that other types of actuation systems may be used to move the membrane back and forth instead of the two-reservoir pneumatic actuation system shown in
3. Fluid Handling
As shown and described with respect to
Referring again to
Pressure sensors are used to monitor pressure in the pneumatic portion of the chambers themselves. By alternating between positive pressure and vacuum on the pneumatic side of the chamber, the membrane is cycled back and forth across the total chamber volume. With each cycle, fluid is drawn through the upstream valve of the inlet fluid port when the pneumatics pull a vacuum on the pods. The fluid is then subsequently expelled through the outlet port and the downstream valve when the pneumatics deliver positive pressure to the pods.
In many embodiments, pressure pumps consist of a pair of chambers. When the two chambers are run 180 degrees out of phase from one another the flow is essentially continuous.
4. Volume Measurement
These flow rates in the cassette are controlled using pressure pod pumps which can detect end of stroke. An outer control loop determines the correct pressure values to deliver the required flow. Pressure pumps can run an end-of-stroke algorithm to detect when each stroke completes. While the membrane is moving, the measured pressure in the chamber tracks a desired sinusoidal pressure. When the membrane contacts a chamber wall, the pressure becomes constant, no longer tracking the sinusoid. This change in the pressure signal is used to detect when the stroke has ended, i.e., the end of stroke.
The pressure pumps have a known volume. Thus, an end of stroke indicates a known volume of fluid is in the chamber. Thus, using the end of stroke, fluid flow may be controlled using rate equating to volume.
As described above in more detail, FMS may be used to determine the volume of fluid pumped by the metering pumps. In some embodiments, the metering pump may pump fluid without using the FMS volume measurement system, however, in the exemplary embodiments, the FMS volume measurement system is used to calculate the exact volume of fluid pumped.
5. Exemplary Embodiment of the Pumping Cassette
Referring now to
Balancing pods 822, 812 in the cassette 800 provide for a desired balance of volume of fluid pumped into and out of the cassette 800, i.e., between the first fluid and the second fluid. The balancing pods 822, 812, however, may be bypassed by way of the metering pump 830. The metering pump 830 pumps a volume of second fluid (or first fluid in other embodiments) out of the fluid line, bypassing the balancing pod 822, 812. Thus, a smaller or reduced volume (i.e., a “new” volume) of the fluid that has been removed by the metering pump 830 will actually enter the balancing pod 822, 812 and thus, the metering pump 830 functions to provide a “new” volume of second fluid by removing the desired volume from the fluid path before the second fluid reaches the balancing pod 822, 812 (or in other embodiments, removing first fluid the desired volume from the fluid path before the second fluid reaches the balancing pod 822, 812) resulting in less first fluid (or in other embodiments, second fluid) being pumped for that pump cycle.
The fluid schematic of the cassette 800 shown in
Referring still to
Referring first to
At the same time, pod pump B 820 includes a volume of second fluid. The volume of second fluid is pumped to balancing pod B 822. Balancing pod B 822 contains a volume of first fluid, and this volume of first fluid is displaced by the volume of second fluid. The volume of first fluid from balancing pod B 822 flows to the second fluid outlet 824 and exits the cassette. A volume of a second fluid enters the cassette at fluid inlet two 826 and flows to pod pump A 828.
Referring still to
First fluid flows into the cassette through the first fluid inlet 810 and flows to balancing pod B 822. The first fluid displaces the second fluid in balancing pod B 822, forcing the second fluid to flow out of the cassette through the first fluid outlet 816. Second fluid flows into the cassette through the second fluid inlet 826 and to pod pump B 820.
The metering pump can be actuated at any time and its function is to remove fluid from the fluid path in order to bypass the balancing pod. Thus, any volume of fluid removed would act to decrease the volume of the other fluid flowing out of the second fluid outlet 824. The metering pump is independent of the balancing pods 812, 822 and the pod pumps 820, 828. The fluid enters through fluid inlet two 826 and is pulled by the metering pump 830. The metering pump then pumps the volume of fluid through the second fluid outlet 816.
Although in the embodiment of the fluid schematic shown in
In the exemplary fluid flow-path embodiment shown in
In the exemplary embodiment, the fluid valves are volcano valves, as described in more detail in this specification. Although the fluid flow-path schematic has been described with respect to a particular flow path, in various embodiments, the flow paths can change based on the actuation of the valves and the pumps. Additionally, the terms inlet and outlet as well as first fluid and second fluid are used for description purposes only. In other embodiments, an inlet can be an outlet, as well as, a first and second fluid may be different fluids or the same fluid types or composition.
Referring now to
Referring now to
Still referring to
The groove 1002 provides a fluid path whereby when the membrane is at the end of stroke, there is still a fluid path between the inlet and outlet such that the pockets of fluid or air do not get trapped in the pod pump or balancing pod. The groove 1002 is included in both the liquid and air sides of the pod pumps 820, 828 and balancing pods 812, 822 (see
The liquid side of the pod pumps 820, 828 and balancing pods 812, 822, in the exemplary embodiment, include a feature whereby the inlet and outlet flow paths are continuous while the outer ring 1004 is also continuous. This feature allows for the seal, formed with the membrane (not shown) to be maintained.
Referring to
Referring now to
In the exemplary embodiment of the cassette, sensor elements are incorporated into the cassette so as to discern various properties of the fluid being pumped. In one embodiment, the three sensor elements are included. In the exemplary embodiment, the sensor elements are located in the sensor cell 1114. The cell 1114 accommodates three sensor elements in the sensor element housings 1116, 1118, 1120. In the exemplary embodiment, two of the sensor housings 1116, 1118 accommodate a conductivity sensor element and the third sensor element housing 1120 accommodates a temperature sensor element. The conductivity sensor elements and temperature sensor elements can be any conductivity or temperature sensor elements in the art. In one embodiment, the conductivity sensor elements are graphite posts. In other embodiments, the conductivity sensor elements are posts made from stainless steel, titanium, platinum or any other metal coated to be corrosion resistant and still be electrically conductive. The conductivity sensor elements will include an electrical lead that transmits the probe information to a controller or other device. In one embodiment, the temperature sensor is a thermister potted in a stainless steel probe. However, in alternate embodiments, a combination temperature and conductivity sensor elements is used similar to the one described in co-pending U.S. Patent Application entitled Sensor Apparatus Systems, Devices and Methods filed Oct. 12, 2007 and published as Publication No. US 2008/0240929. In this embodiment, the sensor cell 1114 is a single opening to the fluid line or a single connection to the fluid line.
In alternate embodiments, there are either no sensors in the cassette or only a temperature sensor, only one or more conductivity sensors or one or more of another type of sensor.
Still referring to
Referring now to
Referring now to
5.1 Membranes
In the exemplary embodiment, the membrane is a double o-ring membrane as shown in
Referring now to
The membrane used in the metering pump 1224, in the preferred embodiment, is shown in more detail in
One embodiment of the conductivity sensor elements 1214, 1216 and the temperature sensor 1218, which make up the sensor cell 1212, are also shown in
5.2 Cross Sectional Views
Referring now to
Referring now to
As described above, the exemplary embodiment is one cassette embodiment that incorporates the exemplary fluid flow-path schematic shown in
Referring now to
Referring now to
Referring now to
Referring now to
5.3 Exemplary Embodiments of the Pumping Cassette
The pumping cassette can be used in a myriad of applications. However, in one exemplary embodiment, the pumping cassette is used to balance fluid going into the first fluid inlet and out the first fluid outlet with fluid coming into the cassette through the second fluid inlet and exiting the cassette through the second fluid outlet (or vice versa). The pumping cassette additionally provides a metering pump to remove a volume of fluid prior to that volume affecting the balancing pods or adds a volume of fluid prior to the fluid affecting the balancing pods.
The pumping cassette may be used in applications where it is critical that two fluid volumes are balanced. Also, the pumping cassette imparts the extra functionality of metering or bypassing a fluid out of the fluid path, or adding a volume of the same fluid or a different fluid into the fluid path. The flow paths shown in the schematic are bi-directional, and various flow paths may be created by changing the valve locations and or controls, or adding or removing valves. Additionally, more metering pumps, pod pumps and/or balancing pods may be added, as well as, more or less fluid paths and valves. Additionally, inlets and outlets may be added as well, or the number of inlets or outlets may be reduced.
One example is using the pumping cassette as an inner dialysate cassette as part of a hemodialysis system. Clean dialysate would enter the cassette through the first fluid inlet and pass through the sensor elements, checking if the dialysate is at the correct concentration and/or temperature. This dialysate would pass through the balancing pods and be pumped through the first fluid outlet and into a dialyzer. The second fluid in this case is used or impure dialysate from the dialyzer. This second fluid would enter through the second fluid inlet and balance with the clean dialysate, such that the amount of dialysate that goes into the dialyzer is equal to the amount that comes out.
The metering pump may be used to remove additional used dialysate prior to that volume being accounted for in a balancing pod, thus, creating a “false” balancing chamber through an ultra filtration (“UF”) bypass. The situation is created where less clean dialysate by a volume equaled to the bypassed volume will enter the dialyzer.
In this embodiment, the valves controlling fluid connections to the balancing chambers shall be oriented such that the volcano feature of the valve is on the fluid port connected to the balancing chamber. This orientation directs most of the fluid displaced by the valve as it is thrown away from the balancing chamber.
The valves controlling fluid connections to the UF pump shall be oriented such that the volcano feature of the valve is on the fluid port connected to the pumping chamber. In the exemplary embodiment, the nominal stroke volume of each inside dialysate pump chamber shall be 38 ml. The nominal volume of each balancing pod shall be 38 ml. The stroke volume of the UF pump shall be 1.2 ml+/−0.05 ml. The inner dialysate pump low-pressure pneumatic variable valves shall vent to ambient atmospheric pressure. This architecture feature minimizes the chance that dissolved gas will leave the dialysate while inside of the balancing chambers. Other volumes of pod pumps, balancing chambers and metering pumps are easily discernable and would vary depending on the application. Additionally, although the embodiment described discusses venting to ambient, in other applications, negative pressure can be administered.
In various embodiments of the cassette, the valve architecture varies in order to alter the fluid flow path. Additionally, the sizes of the pod pumps, metering pump and balancing pods may also vary, as well as the number of valves, pod pumps, metering pumps and balancing pods. Although in this embodiment, the valves are volcano valves, in other embodiments, the valves are not volcano valves and in some embodiments are smooth surface valves.
While the principles of the invention have been described herein, it is to be understood by those skilled in the art that this description is made only by way of example and not as a limitation as to the scope of the invention. Other embodiments are contemplated within the scope of the present invention in addition to the exemplary embodiments shown and described herein. Modifications and substitutions by one of ordinary skill in the art are considered to be within the scope of the present invention.
This application is a continuation of U.S. patent application Ser. No. 17/107,495, filed on Nov. 30, 2020, which is a continuation of U.S. patent application Ser. No. 16/133,279, filed on Sep. 17, 2018, and issued on Dec. 1, 2020 as U.S. Pat. No. 10,851,769, which is a continuation of U.S. patent application Ser. No. 15/635,780, filed on Jun. 28, 2017, and issued on Sep. 18, 2018 as U.S. Pat. No. 10,077,766, which is a continuation of U.S. patent application Ser. No. 14/589,829, filed on Jan. 5, 2015 and issued on Jul. 11, 2017 as U.S. Pat. No. 9,700,660, which is a continuation of U.S. patent application Ser. No. 13/684,995, filed on Nov. 26, 2012 and issued on Jan. 6, 2015 as U.S. Pat. No. 8,926,294, which is a continuation of U.S. patent application Ser. No. 11/871,712, filed on Oct. 12, 2007 and issued on Nov. 27, 2012 as U.S. Pat. No. 8,317,492, which claims priority from the following U.S. Provisional Patent Applications: U.S. Provisional Patent Application No. 60/904,024 entitled Hemodialysis System and Methods filed on Feb. 27, 2007; and U.S. Provisional Patent Application No. 60/921,314 entitled Sensor Apparatus filed on Apr. 2, 2007. Each of the above-indicated priority applications are hereby incorporated by reference in their entireties.
| Number | Name | Date | Kind |
|---|---|---|---|
| 3111125 | Schulte et al. | Nov 1963 | A |
| 3568214 | Goldschmied et al. | Mar 1971 | A |
| 4083777 | Hutchisson | Apr 1978 | A |
| 4137168 | Perrot | Jan 1979 | A |
| 4267040 | Schal | May 1981 | A |
| 4269708 | Bonomini et al. | May 1981 | A |
| 4386634 | Stasz et al. | Jun 1983 | A |
| 4441357 | Kahn et al. | Apr 1984 | A |
| 4583920 | Lindner | Apr 1986 | A |
| 4594058 | Fischell | Jun 1986 | A |
| 4623334 | Riddell | Nov 1986 | A |
| 4623450 | Vantard et al. | Nov 1986 | A |
| 4770769 | Schael | Sep 1988 | A |
| 4778451 | Kamen | Oct 1988 | A |
| 4808161 | Kamen | Feb 1989 | A |
| 4826482 | Kamen | May 1989 | A |
| 4897184 | Shouldice et al. | Jan 1990 | A |
| 4971700 | Tsuji et al. | Nov 1990 | A |
| 4976162 | Kamen | Dec 1990 | A |
| 4997570 | Polaschegg | Mar 1991 | A |
| 5002471 | Perlov | Mar 1991 | A |
| 5178182 | Kamen | Jan 1993 | A |
| 5247434 | Peterson et al. | Sep 1993 | A |
| 5275724 | Bucchianeri et al. | Jan 1994 | A |
| 5318414 | Lundback | Jun 1994 | A |
| 5350357 | Kamen et al. | Sep 1994 | A |
| 5415528 | Ogden et al. | May 1995 | A |
| 5421823 | Kamen et al. | Jun 1995 | A |
| 5423738 | Robinson et al. | Jun 1995 | A |
| 5431627 | Pastrone et al. | Jul 1995 | A |
| 5438510 | Bryant et al. | Aug 1995 | A |
| 5458468 | Ye et al. | Oct 1995 | A |
| 5470483 | Bene et al. | Nov 1995 | A |
| 5472325 | Svendsen | Dec 1995 | A |
| 5486286 | Peterson et al. | Jan 1996 | A |
| 5542919 | Simon et al. | Aug 1996 | A |
| 5566718 | Nagai et al. | Oct 1996 | A |
| 5575310 | Kamen et al. | Nov 1996 | A |
| 5580460 | Polaschegg | Dec 1996 | A |
| 5609572 | Lang | Mar 1997 | A |
| 5660722 | Nederlof | Aug 1997 | A |
| 5676644 | Toavs et al. | Oct 1997 | A |
| 5704520 | Gross | Jan 1998 | A |
| 5744027 | Connell et al. | Apr 1998 | A |
| 5808181 | Wamsiedler | Sep 1998 | A |
| 5836908 | Beden et al. | Nov 1998 | A |
| 6041801 | Gray et al. | Mar 2000 | A |
| 6042784 | Wamsiedler | Mar 2000 | A |
| 6165154 | Gray et al. | Dec 2000 | A |
| 6261065 | Nayak et al. | Jul 2001 | B1 |
| 6284131 | Hogard et al. | Sep 2001 | B1 |
| 6302653 | Bryant et al. | Oct 2001 | B1 |
| 6321597 | Demers et al. | Nov 2001 | B1 |
| 6382257 | Mead et al. | May 2002 | B2 |
| 6382923 | Gray | May 2002 | B1 |
| 6416293 | Bouchard et al. | Jul 2002 | B1 |
| 6419462 | Horie et al. | Jul 2002 | B1 |
| 6481980 | Vandlik et al. | Nov 2002 | B1 |
| 6485263 | Bryant et al. | Nov 2002 | B1 |
| 6491656 | Morris | Dec 2002 | B1 |
| 6503062 | Gray et al. | Jan 2003 | B1 |
| 6505691 | Judge et al. | Jan 2003 | B2 |
| 6520747 | Gray et al. | Feb 2003 | B2 |
| 6579074 | Chiba | Jun 2003 | B2 |
| 6638478 | Treu et al. | Oct 2003 | B1 |
| 6692457 | Flaherty | Feb 2004 | B2 |
| 6709417 | Houle et al. | Mar 2004 | B1 |
| 6726656 | Kamen et al. | Apr 2004 | B2 |
| 6752172 | Lauer | Jun 2004 | B2 |
| 6752599 | Park | Jun 2004 | B2 |
| 6852090 | Burbank et al. | Feb 2005 | B2 |
| 6905314 | Danby | Jun 2005 | B2 |
| 6905479 | Bouchard et al. | Jun 2005 | B1 |
| 6929751 | Bowman, Jr. et al. | Aug 2005 | B2 |
| 6939471 | Gross | Sep 2005 | B2 |
| 7029245 | Maianti et al. | Apr 2006 | B2 |
| 7044432 | Beden et al. | May 2006 | B2 |
| 7175606 | Bowman, Jr. et al. | Feb 2007 | B2 |
| 7232418 | Neri et al. | Jun 2007 | B2 |
| 7238164 | Childers et al. | Jul 2007 | B2 |
| 7300413 | Burbank | Nov 2007 | B2 |
| 7318292 | Helbling et al. | Jan 2008 | B2 |
| 7364563 | Lucke et al. | Apr 2008 | B2 |
| 7473238 | Brugger et al. | Jan 2009 | B2 |
| 7500962 | Childers et al. | Mar 2009 | B2 |
| 7559524 | Gray et al. | Jul 2009 | B2 |
| 7648627 | Beden et al. | Jan 2010 | B2 |
| 7699806 | Ware et al. | Apr 2010 | B2 |
| 7727176 | Tonelli et al. | Jun 2010 | B2 |
| 7744553 | Kelly et al. | Jun 2010 | B2 |
| 7776006 | Childers et al. | Aug 2010 | B2 |
| 7794141 | Perry et al. | Sep 2010 | B2 |
| 7798997 | Kamen et al. | Sep 2010 | B2 |
| 7867214 | Childers et al. | Jan 2011 | B2 |
| 7892331 | Childers et al. | Feb 2011 | B2 |
| 7909795 | Childers et al. | Mar 2011 | B2 |
| 7967022 | Grant et al. | Jun 2011 | B2 |
| 8029454 | Kelly et al. | Oct 2011 | B2 |
| 8038639 | Lo et al. | Oct 2011 | B2 |
| 8038640 | Orr | Oct 2011 | B2 |
| 8042563 | Wilt et al. | Oct 2011 | B2 |
| 8105265 | Demers et al. | Jan 2012 | B2 |
| 8113244 | Kamen et al. | Feb 2012 | B2 |
| 8137553 | Fulkerson et al. | Mar 2012 | B2 |
| 8197439 | Wang et al. | Jun 2012 | B2 |
| 8211048 | Szamosfalvi et al. | Jul 2012 | B2 |
| 8246826 | Wilt et al. | Aug 2012 | B2 |
| 8273049 | Demers et al. | Sep 2012 | B2 |
| 8287480 | Sasaki et al. | Oct 2012 | B2 |
| 8292594 | Tracey et al. | Oct 2012 | B2 |
| 8317492 | Demers et al. | Nov 2012 | B2 |
| 8357298 | Demers et al. | Jan 2013 | B2 |
| 8393690 | Grant et al. | Mar 2013 | B2 |
| 8409441 | Wilt | Apr 2013 | B2 |
| 8425471 | Grant et al. | Apr 2013 | B2 |
| 8459292 | Wilt et al. | Jun 2013 | B2 |
| 8469331 | Burbank et al. | Jun 2013 | B2 |
| 8491184 | Kamen et al. | Jul 2013 | B2 |
| 8499780 | Wilt et al. | Aug 2013 | B2 |
| 8512553 | Cicchello et al. | Aug 2013 | B2 |
| 8535525 | Heyes et al. | Sep 2013 | B2 |
| 8545698 | Wilt et al. | Oct 2013 | B2 |
| 8556225 | Gray | Oct 2013 | B2 |
| 8562834 | Kamen et al. | Oct 2013 | B2 |
| 8597229 | Pan | Dec 2013 | B2 |
| 8721879 | Van der Merwe et al. | May 2014 | B2 |
| 8721884 | Wilt et al. | May 2014 | B2 |
| 8728020 | Caleffi et al. | May 2014 | B2 |
| 8764702 | Childers et al. | Jul 2014 | B2 |
| 8771508 | Grant et al. | Jul 2014 | B2 |
| 8858787 | Muller et al. | Oct 2014 | B2 |
| 8863772 | Dale et al. | Oct 2014 | B2 |
| 8870549 | Tracey et al. | Oct 2014 | B2 |
| 8888470 | Demers et al. | Nov 2014 | B2 |
| 8926294 | Demers et al. | Jan 2015 | B2 |
| 8968232 | Kamen et al. | Mar 2015 | B2 |
| 8985133 | Grant et al. | Mar 2015 | B2 |
| 8992075 | Kamen et al. | Mar 2015 | B2 |
| 8992189 | Wilt et al. | Mar 2015 | B2 |
| 9028691 | Grant et al. | May 2015 | B2 |
| 9039395 | Gray et al. | May 2015 | B2 |
| 9072831 | Kelly et al. | Jul 2015 | B2 |
| 9115708 | van der Merwe et al. | Aug 2015 | B2 |
| 9272082 | Demers et al. | Mar 2016 | B2 |
| 9302037 | Wilt et al. | Apr 2016 | B2 |
| 9302039 | Kelly et al. | Apr 2016 | B2 |
| 9364655 | Grant et al. | Jun 2016 | B2 |
| 9488167 | Gray et al. | Nov 2016 | B2 |
| 9494151 | Gray et al. | Nov 2016 | B2 |
| 9517295 | Wilt et al. | Dec 2016 | B2 |
| 9535021 | Kamen et al. | Jan 2017 | B2 |
| 9539379 | Grant et al. | Jan 2017 | B2 |
| 9550018 | Demers et al. | Jan 2017 | B2 |
| 9555179 | Wilt et al. | Jan 2017 | B2 |
| 9593678 | Gray et al. | Mar 2017 | B2 |
| 9597442 | Wilt | Mar 2017 | B2 |
| 9603985 | Wilt et al. | Mar 2017 | B2 |
| 9649418 | Demers et al. | May 2017 | B2 |
| 9677554 | Wilt et al. | Jun 2017 | B2 |
| 9700660 | Demers et al. | Jul 2017 | B2 |
| 9700711 | Grant et al. | Jul 2017 | B2 |
| 9717834 | Wilt et al. | Aug 2017 | B2 |
| 9724458 | Grant et al. | Aug 2017 | B2 |
| 9750865 | Vasta et al. | Sep 2017 | B2 |
| 9770546 | Vasta | Sep 2017 | B2 |
| 9795728 | Grant et al. | Oct 2017 | B2 |
| 9951768 | Grant et al. | Apr 2018 | B2 |
| 9987407 | Grant et al. | Jun 2018 | B2 |
| 9999717 | van der Merwe et al. | Jun 2018 | B2 |
| 10058694 | Norris et al. | Aug 2018 | B2 |
| 10060867 | Kamen et al. | Aug 2018 | B2 |
| 10077766 | Demers et al. | Sep 2018 | B2 |
| 10098998 | Wilt | Oct 2018 | B2 |
| 10201647 | Norris et al. | Feb 2019 | B2 |
| 10201650 | Wilt et al. | Feb 2019 | B2 |
| 10302075 | Tracey et al. | May 2019 | B2 |
| 10415559 | Demers et al. | Sep 2019 | B2 |
| 10441697 | Kamen et al. | Oct 2019 | B2 |
| 10443591 | Wilt et al. | Oct 2019 | B2 |
| 10449280 | Wilt et al. | Oct 2019 | B2 |
| 10463774 | Ballantyne et al. | Nov 2019 | B2 |
| 10500327 | Grant et al. | Dec 2019 | B2 |
| 10537671 | Wilt et al. | Jan 2020 | B2 |
| 10682450 | Wilt et al. | Jun 2020 | B2 |
| 10697913 | Kamen et al. | Jun 2020 | B2 |
| 10780210 | Grant et al. | Sep 2020 | B2 |
| 10780213 | Grant et al. | Sep 2020 | B2 |
| 10799628 | Wilt et al. | Oct 2020 | B2 |
| 10850089 | Grant et al. | Dec 2020 | B2 |
| 10851769 | Demers et al. | Dec 2020 | B2 |
| 10871157 | Tracey et al. | Dec 2020 | B2 |
| 11033671 | van der Merwe et al. | Jun 2021 | B2 |
| 11052181 | Wilt et al. | Jul 2021 | B2 |
| 11103625 | Wilt | Aug 2021 | B2 |
| 11110212 | Grant et al. | Sep 2021 | B2 |
| 11154646 | Wilt et al. | Oct 2021 | B2 |
| 11197951 | Wilt et al. | Dec 2021 | B2 |
| 11311656 | Kamen et al. | Apr 2022 | B2 |
| 11371498 | Grant et al. | Jun 2022 | B2 |
| 11400272 | Norris et al. | Aug 2022 | B2 |
| 11419965 | Demers et al. | Aug 2022 | B2 |
| 11529444 | Wilt et al. | Dec 2022 | B2 |
| 11568043 | Ballantyne et al. | Jan 2023 | B2 |
| 11598329 | Grant et al. | Mar 2023 | B2 |
| 11633526 | Wilt et al. | Apr 2023 | B2 |
| 11666690 | Wilt et al. | Jun 2023 | B2 |
| 11724011 | Wilt et al. | Aug 2023 | B2 |
| 11725645 | Wilt et al. | Aug 2023 | B2 |
| 11752244 | Grant et al. | Sep 2023 | B2 |
| 11752248 | Beavers et al. | Sep 2023 | B2 |
| 11754064 | Tracey et al. | Sep 2023 | B2 |
| 11766554 | Grant et al. | Sep 2023 | B2 |
| 11779689 | van der Merwe et al. | Oct 2023 | B2 |
| 11779691 | Demers et al. | Oct 2023 | B2 |
| 11793915 | Wilt et al. | Oct 2023 | B2 |
| 11828279 | Wilt et al. | Nov 2023 | B2 |
| 20020103453 | Burbank et al. | Aug 2002 | A1 |
| 20040136843 | Jahn et al. | Jul 2004 | A1 |
| 20040211718 | Deguchi et al. | Oct 2004 | A1 |
| 20040243049 | Brugger et al. | Dec 2004 | A1 |
| 20050045540 | Connell et al. | Mar 2005 | A1 |
| 20050145010 | Vanderveen et al. | Jul 2005 | A1 |
| 20060002823 | Feldstein | Jan 2006 | A1 |
| 20070077156 | Orr | Apr 2007 | A1 |
| 20070135758 | Childers et al. | Jun 2007 | A1 |
| 20070278155 | Lo et al. | Dec 2007 | A1 |
| 20080015515 | Hopkins et al. | Jan 2008 | A1 |
| 20080058697 | Kamen et al. | Mar 2008 | A1 |
| 20080077068 | Orr | Mar 2008 | A1 |
| 20080132828 | Howard | Jun 2008 | A1 |
| 20080175719 | Tracey et al. | Jul 2008 | A1 |
| 20080203023 | Burbank et al. | Aug 2008 | A1 |
| 20080216898 | Grant et al. | Sep 2008 | A1 |
| 20080253911 | Demers et al. | Oct 2008 | A1 |
| 20090076434 | Mischelevich et al. | Mar 2009 | A1 |
| 20090095679 | Demers et al. | Apr 2009 | A1 |
| 20090107335 | Wilt et al. | Apr 2009 | A1 |
| 20090107902 | Childers et al. | Apr 2009 | A1 |
| 20090124963 | Hogard et al. | May 2009 | A1 |
| 20090137940 | Orr | May 2009 | A1 |
| 20090182263 | Burbank et al. | Jul 2009 | A1 |
| 20090294359 | Hopping et al. | Dec 2009 | A1 |
| 20100056975 | Dale et al. | Mar 2010 | A1 |
| 20100187176 | Del Canizo Lopez | Jul 2010 | A1 |
| 20100296953 | Gray | Nov 2010 | A1 |
| 20110005992 | Kelly et al. | Jan 2011 | A1 |
| 20110060204 | Weston | Mar 2011 | A1 |
| 20110071465 | Wang et al. | Mar 2011 | A1 |
| 20110105877 | Wilt et al. | May 2011 | A1 |
| 20110218600 | Kamen et al. | Sep 2011 | A1 |
| 20120106289 | Wilt et al. | May 2012 | A1 |
| 20130022483 | Wilt et al. | Jan 2013 | A1 |
| 20130074959 | Demers et al. | Mar 2013 | A1 |
| 20130126413 | van der Merwe et al. | May 2013 | A1 |
| 20130204174 | Olde et al. | Aug 2013 | A1 |
| 20130304020 | Wilt et al. | Nov 2013 | A1 |
| 20140112828 | Grant et al. | Apr 2014 | A1 |
| 20140153356 | Giant et al. | Jun 2014 | A1 |
| 20140199193 | Wilt et al. | Jul 2014 | A1 |
| 20140207062 | Eagle et al. | Jul 2014 | A1 |
| 20140260551 | Gray et al. | Sep 2014 | A1 |
| 20140260556 | Gray et al. | Sep 2014 | A1 |
| 20140276428 | Gray et al. | Sep 2014 | A1 |
| 20140286794 | Gray et al. | Sep 2014 | A1 |
| 20140309611 | Wilt et al. | Oct 2014 | A1 |
| 20140322053 | van der Merwe et al. | Oct 2014 | A1 |
| 20150050166 | Tracey et al. | Feb 2015 | A1 |
| 20150125319 | Demers et al. | May 2015 | A1 |
| 20150151047 | Anderson et al. | Jun 2015 | A1 |
| 20150196698 | Grant et al. | Jul 2015 | A1 |
| 20150196699 | Wilt et al. | Jul 2015 | A9 |
| 20150265760 | Wilt et al. | Sep 2015 | A1 |
| 20160030657 | Kelly et al. | Feb 2016 | A1 |
| 20160082173 | Coll et al. | Mar 2016 | A1 |
| 20160101227 | Norris et al. | Apr 2016 | A1 |
| 20160101278 | Norris et al. | Apr 2016 | A1 |
| 20160175505 | Demers et al. | Jun 2016 | A1 |
| 20160175506 | Wilt et al. | Jun 2016 | A1 |
| 20180368704 | Kawamura et al. | Dec 2018 | A1 |
| 20180372084 | Grant et al. | Dec 2018 | A1 |
| 20200400595 | Kamen et al. | Dec 2020 | A1 |
| 20210030938 | Kopperschmidt | Feb 2021 | A1 |
| 20210060231 | Grant et al. | Mar 2021 | A1 |
| 20210316058 | van der Merwe et al. | Oct 2021 | A1 |
| 20220152286 | Wilt et al. | May 2022 | A1 |
| 20220241479 | Kamen et al. | Aug 2022 | A1 |
| 20220355006 | Demers et al. | Nov 2022 | A1 |
| 20230177149 | Ballantyne et al. | Jun 2023 | A1 |
| 20230256148 | Wilt et al. | Aug 2023 | A1 |
| 20230272791 | Grant et al. | Aug 2023 | A1 |
| 20230287876 | Wilt et al. | Sep 2023 | A1 |
| 20230338632 | Wilt et al. | Oct 2023 | A1 |
| 20230364312 | Grant et al. | Nov 2023 | A1 |
| 20230381383 | van der Merwe et al. | Nov 2023 | A1 |
| 20230398274 | Wilt et al. | Dec 2023 | A1 |
| 20230400425 | Kamen et al. | Dec 2023 | A1 |
| Number | Date | Country |
|---|---|---|
| 1323312 | Oct 1993 | CA |
| 2704411 | May 2009 | CA |
| 3328744 | Feb 1985 | DE |
| 0 288 145 | Oct 1988 | EP |
| 0 406 562 | Jan 1991 | EP |
| 1 356 836 | Oct 2003 | EP |
| S58-169462 | Oct 1983 | JP |
| S60-30489 | Feb 1985 | JP |
| S61-167492 | Oct 1986 | JP |
| H06-207845 | Jul 1994 | JP |
| H06-237988 | Aug 1994 | JP |
| H07-100199 | Apr 1995 | JP |
| H09-287441 | Nov 1997 | JP |
| H10-196814 | Jul 1998 | JP |
| 2000-167040 | Jun 2000 | JP |
| 2001-009025 | Jan 2001 | JP |
| 2002-113096 | Apr 2002 | JP |
| 2004-147721 | May 2004 | JP |
| 2005-013502 | Jan 2005 | JP |
| 2005-021246 | Jan 2005 | JP |
| 2005-034671 | Feb 2005 | JP |
| 2005-261558 | Sep 2005 | JP |
| 3865150 | Jan 2007 | JP |
| 2007-035582 | Feb 2007 | JP |
| WO 8402473 | Jul 1984 | WO |
| WO 9420157 | Sep 1994 | WO |
| WO 9625214 | Aug 1996 | WO |
| WO 9910028 | Mar 1999 | WO |
| WO 01037895 | May 2001 | WO |
| WO 0230267 | Apr 2002 | WO |
| WO 03008076 | Jan 2003 | WO |
| WO 03099353 | Dec 2003 | WO |
| WO 03101510 | Dec 2003 | WO |
| WO 2006120415 | Nov 2006 | WO |
| WO 2007120812 | Oct 2007 | WO |
| WO 2009006498 | Jan 2009 | WO |
| WO 2010139918 | Dec 2010 | WO |
| WO 2015183976 | Dec 2015 | WO |
| WO 2015183981 | Dec 2015 | WO |
| Entry |
|---|
| Office Action for AU Application No. 2022202714 dated Aug. 28, 2023 and claims pending as of Aug. 28, 2023. |
| Examiner's Report for CA Application No. 3,045,352 filed Feb. 26, 2008, which Examiner's Report was mailed May 19, 2020, and claims as pending for CA Application No. 3,045,352 as of May 19, 2020. |
| Office Action for CN Application No. 200880013766.6 filed Oct. 27, 2009, published as CN 101678159 on Mar. 24, 2010, which Office Action is dated Mar. 23, 2012, and claims as pending for CN Application No. 200880013766.6 as of Mar. 23, 2012. |
| Response to Communication dated Sep. 19, 2012 for EP Application No. 08730740.1 filed Sep. 25, 2009, which Response is dated Mar. 20, 2013, and claims as pending for EP Application No. 08730740.1 as of Mar. 20, 2013. |
| Examination Report for EP Application No. 08730740.1 filed Sep. 25, 2009, published as EP 2131886 on Dec. 16, 2009, which Office Action is dated Sep. 18, 2014, and claims as pending for EP Application No. 08730740.1 as of Sep. 18, 2014. |
| Extended European Search Report for EP Application No. 19161594.7 dated Nov. 12, 2019 and claims pending as of Nov. 12, 2019. |
| Office Action for IN Application No. 6140/DELNP/2009 filed Sep. 24, 2009, which Office Action is dated Aug. 30, 2017, and claims as pending for IN Application No. 6140/DELNP/2009 as of Aug. 30, 2017. |
| First Examination Report for IN Application No. 201718040630 dated Oct. 11, 2021 and claims pending as of Oct. 11, 2021. |
| Office Action for JP Application No. 2012-282805 filed Dec. 26, 2012, unpublished as of Dec. 24, 2013, which Office Action is dated Dec. 24, 2013, and claims as pending for JP Application No. 2012-282805 as of Dec. 24, 2013. |
| Office Action for JP Application No. 2019-213144 dated Aug. 3, 2021 and claims pending as of Aug. 3, 2021. |
| Office Action for JP Application No. JP 2019-213144 dated Mar. 8, 2022 and pending claims as of Mar. 8, 2022. |
| Office Action for KR Application No. 10-2009-7020133 filed Sep. 25, 2009, unpublished as of Apr. 16, 2015, which Office Action is dated Apr. 16, 2015, and claims as pending for KR Application No. 10-2009-7020133 as of Apr. 16, 2015. |
| Office Action for KR Application No. 10-2009-7020133 filed Sep. 25, 2009, unpublished as of Apr. 16, 2015, which Office Action is dated Jan. 21, 2016, and claims as pending for KR Application No. 10-2009-7020133 as of Jan. 21, 2016. |
| Office Action for KR Application No. 10-2014-7033704 filed Dec. 1, 2014, unpublished as of Feb. 16, 2015, which Office Action is dated Feb. 16, 2015, and claims as pending for KR Application No. 10-2014-7033704 as of Feb. 16, 2015. |
| Office Action for MX Application No. MX/a/2014/001513 filed Aug. 27, 2009, which Office Action is dated Aug. 18, 2017, and claims as pending for MX Application No. MX/a/2014/001513 as of Aug. 18, 2017. |
| International Search Report and Written Opinion for Application No. PCT/US2008/055000 mailed Aug. 1, 2008. |
| International Preliminary Report on Patentability for Application No. PCT/US2008/055000 mailed Sep. 11, 2009. |
| Office Action for U.S. Appl. No. 11/871,680, published as US 2008-0208103 on Aug. 28, 2008 which Office Action is dated Aug. 22, 2011, and claims as pending for U.S. Appl. No. 11/871,680 as of Aug. 22, 2011. |
| Office Action for U.S. Appl. No. 11/871,712, published as US 2009/0004033 on Jan. 1, 2009, which Office Action is dated Feb. 4, 2010, and claims as pending for U.S. Appl. No. 11/871,712 as of Feb. 4, 2010. |
| Office Action for U.S. Appl. No. 11/871,712, published as US 2009-0004033 on Jan. 1, 2009, which Office Action is dated Oct. 15, 2010, and claims as pending for U.S. Appl. No. 11/871,712 as of Oct. 15, 2010. |
| Office Action for U.S. Appl. No. 11/871,712, published as US 2009-0004033 on Jan. 1, 2009, which Office Action is dated Feb. 7, 2011, and claims as pending for U.S. Appl. No. 11/871,712 as of Feb. 7, 2011. |
| Office Action for U.S. Appl. No. 11/871,787, published as US 2008-0253911 on Oct. 16, 2008, which Office Action is dated Apr. 14, 2011, and claims as pending for U.S. Appl. No. 11/871,787 as of Apr. 14, 2011. |
| Office Action for U.S. Appl. No. 11/871,793, published as US 2008-0253912 on Oct. 16, 2008, which Office Action is dated Apr. 28, 2011, and claims as pending for U.S. Appl. No. 11/871,793 as of Apr. 28, 2011. |
| Office Action for U.S. Appl. No. 11/871,793, published as US 2008-0253912 on Oct. 16, 2008, which Office Action is dated Nov. 28, 2011, and claims as pending for U.S. Appl. No. 11/871,793 as of Nov. 28, 2011. |
| Office Action for U.S. Appl. No. 11/871,793, published as US 2008-0253912 on Oct. 16, 2008, which Office Action is dated Oct. 29, 2013, and claims as pending for U.S. Appl. No. 11/871,793 as of Oct. 29, 2013. |
| Office Action for U.S. Appl. No. 13/352,250, published as US 2012-0207627 on Aug. 16, 2012, which Office Action is dated Feb. 27, 2015, and claims as pending for U.S. Appl. No. 13/352,250 as of Feb. 27, 2015. |
| Office Action for U.S. Appl. No. 13/352,250, published as US 2012-0207627 on Aug. 16, 2012, which Office Action is dated Dec. 3, 2015, and claims as pending for U.S. Appl. No. 13/352,250 as of Dec. 3, 2015. |
| Office Action for U.S. Appl. No. 13/352,250, published as US 2012-0207627 on Aug. 16, 2012, which Office Action is dated Aug. 23, 2016, and claims as pending for U.S. Appl. No. 13/352,250 as of Aug. 23, 2016. |
| Office Action for U.S. Appl. No. 13/624,460, published as US 2013-0074959 on Mar. 28, 2013, which Office Action is dated Jan. 16, 2015, and claims as pending for U.S. Appl. No. 13/624,460 as of Jan. 16, 2015. |
| Office Action for U.S. Appl. No. 13/684,995, published as 2013-0177457 on Jul. 11, 2013, which Office Action is dated Jun. 21, 2013, and claims as pending for U.S. Appl. No. 13/684,995 as of Jun. 21, 2013. |
| Grant et al., Hemodialysis System. U.S. Appl. No. 18/394,189, filed Dec. 22, 2023. |
| Mineshima et al., Efficacy of internal filtration enhanced hemodialysis. Artificial Organs. 1999;28(1):127-33. Abstract only. |
| Number | Date | Country | |
|---|---|---|---|
| 20240066197 A1 | Feb 2024 | US |
| Number | Date | Country | |
|---|---|---|---|
| 60921314 | Apr 2007 | US | |
| 60904024 | Feb 2007 | US |
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|---|---|---|---|
| Parent | 17107495 | Nov 2020 | US |
| Child | 18460492 | US | |
| Parent | 16133279 | Sep 2018 | US |
| Child | 17107495 | US | |
| Parent | 15635780 | Jun 2017 | US |
| Child | 16133279 | US | |
| Parent | 14589829 | Jan 2015 | US |
| Child | 15635780 | US | |
| Parent | 13684995 | Nov 2012 | US |
| Child | 14589829 | US | |
| Parent | 11871712 | Oct 2007 | US |
| Child | 13684995 | US |
