Claims
- 1. A process for the production of the cephalosporins cefixime or cefdinir comprising the steps ofa) depleting 7-ADCA of formula from a mixture of 7-ADCA with vinyl-ACA of formula by forming and isolating a crystalline salt of vinyl-ACA with a cation of formula wherein R1, R2 and R3 are the same or different and independently of one another denote hydrogen, alkyl, aryl, aralkyl or cycloalkyl; or R1 and R2 together with the nitrogen atom form a 5- or 6-membered heterocycle containing one or several heteroatoms selected from the group consisting of N, S and O and R3 is as defined above; in a solvent in which the salt of 7-ADCA has a higher solubility than the salt of vinyl-ACA, wherein the solvent is selected from amides, ketones, alcohols, nitriles, esters, chlorinated hydrocarbons, water, or mixtures thereof, and wherein the salt forming agent is NR1R2R3 or an organic salt thereof, and converting said salt into vinyl-ACA in free form by adding an acid; and b) further substituting vinyl-ACA by introducing the corresponding 7-acyl group to obtain cefdinir or cefixime.
Priority Claims (1)
Number |
Date |
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Kind |
A 1369/95 |
Aug 1995 |
AT |
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Parent Case Info
This application is a continuation of prior application U.S. Ser. No. 09/880,213, filed Jun. 13, 2001, now abandoned; which in turn was a division of U.S. Ser. No. 09/567,623, filed May 9, 2000, now U.S. Pat. No. 6,284,888, issued Sep. 4, 2001; which in turn was a continuation of U.S. Ser. No. 09/011,388 filed Apr. 20, 1998, now abandoned; which was filed as a 371 of international application No. PCT/EP06/03582 on Aug. 13, 1998.
US Referenced Citations (9)
Foreign Referenced Citations (4)
Number |
Date |
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A 0 503 453 |
Sep 1992 |
EP |
A 0 597 429 |
May 1994 |
EP |
WO A 93 16084 |
Aug 1993 |
WO |
WO 9316084 |
Aug 1993 |
WO |
Non-Patent Literature Citations (1)
Entry |
Takagugi C.A. 112 (21) No 197966. |
Continuations (2)
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Number |
Date |
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Parent |
09/880213 |
Jun 2001 |
US |
Child |
10/348569 |
|
US |
Parent |
09/011388 |
|
US |
Child |
09/567623 |
|
US |