Claims
- 1. An antibiotic product comprising:
- at least one Group B streptogramin of the formula (I) and
- at least one Group A streptogramin of the formula (II),
- wherein said at least one Group B streptogramin of the formula (I) has the formula: ##STR9## wherein (1) A.sub.1 is a radical of the formula (Ia) or (Ia') ##STR10## wherein R' is a hydrogen atom or a hydroxyl radical, and Y is a hydrogen atom, a methylamino radical or a dimethylamino radical, and R is an ethyl radical, or when R' represents a hydrogen atom, R can also represent a methyl radical, and R.sub.1 and R.sub.2 each represent a hydrogen atom, or
- (2) A.sub.1 is a radical of formula (Ib): ##STR11## wherein R is an isobutyl radical, and R.sub.1 is a hydroxyl radical and R.sub.2 is a methyl radical;
- wherein said at least one Group A streptogramin of the formula (II) has the formula: ##STR12## wherein R" is a hydrogen atom, a methyl radical or an ethyl radical; and with the proviso that if Group A streptogramin PIIA of the formula ##STR13## is present in said product, said PIIA is not the majority component of the Group A streptogramins in said product.
- 2. An antibiotic product according to claim 1, wherein said at least one Group B streptogramin of the formula (I) and said at least one Group A streptogramin of the formula (II) are in the form of a cocrystallizate.
- 3. An antibiotic product according to claim 1, wherein said at least one Group B streptogramin of the formula (I) and said at least one Group A streptogramin of the formula (II) are in the form of a coprecipitate.
- 4. An antibiotic product according to claim 3, wherein said coprecipitate contains a proportion of from 10:90 to 90:10, respectively, by weight of the Group A streptogramin of the formula (II) to the Group B streptogramin of the formula (I), and wherein said weight proportion in said coprecipitate does not contain a molar ratio of the Group B streptogramin of the formula (I) to the Group A streptogramin of the formula (II) on order of 1:2.
- 5. An antibiotic product according to claim 4, wherein said weight proportion in said coprecipitate is from 20:80 to 80:20.
- 6. An antibiotic product according to claim 1, wherein said at least one Group B streptogramin of the formula (I) and said at least one Group A streptogramin of the formula (II) are in the form of a physical mixture of powders.
- 7. An antibiotic product according to claim 6, wherein said physical mixture of powders contains a proportion of from 10:90 to 90:10, respectively, by weight of the Group A streptogramin of the formula (II) to the Group B streptogramin of the formula (I).
- 8. An antibiotic product according to claim 7, wherein said weight proportion in said physical mixture of powders is from 20:80 to 80:20.
- 9. An antibiotic product according to claim 1, wherein said PIIA is present in an amount less than 6% of said product.
- 10. An antibiotic product according to claim 9, wherein said PIIA is present in an amount less than 3% of said product.
- 11. An antibiotic product according to claim 1,
- wherein in said at least one Group A streptogramin of the formula (II), R" is a methyl radical, and
- wherein in said at least one Group B streptogramin of the formula (I),
- A.sub.1 is a radical of the formula (Ia), and either R' is a hydrogen atom, Y is a methylamino radical or a dimethylamino radical, R.sub.1 and R.sub.2 each represent a hydrogen atom, and R is a ethyl or methyl radical or
- R' is a hydroxyl radical, Y is a dimethylamino radical, R.sub.1 and R.sub.2 each represent a hydrogen atom, and R is a ethyl radical.
- 12. An antibiotic product according to claim 1,
- wherein in said at least one Group A streptogramin of the formula (II), R" is a methyl radical, and
- wherein in said at least one Group B streptogramin of the formula (I), A.sub.1 is a radical of the formula (Ia), R" is a hydrogen atom, Y is a methylamino radical, R.sub.1 and R.sub.2 each represents a hydrogen atom, and R is a ethyl radical.
- 13. An antibiotic product according to claim 1,
- wherein in said at least one Group A streptogramin of the formula (II), R" is a methyl radical, and
- wherein either:
- there are two Group B streptogramins of the formula (I), A.sub.1 being a radical of the formula (Ia), R' being a hydrogen atom, Y being a hydrogen atom, R.sub.1 and R.sub.2 each being a hydrogen atom, and R in one of said two streptogramins of the formula (I) being a ethyl radical and R in the other of said two streptogramins of the formula (I) being a methyl radical; or
- there is one Group B streptogramin of the formula (I), A.sub.1 being a radical of the formula (Ia), R' being a hydrogen atom, Y being a hydrogen atom, R.sub.1 and R.sub.2 each being a hydrogen atom, and R being a ethyl radical.
- 14. A pharmaceutical composition containing an antibiotically effective amount of the antibiotic product of claim 1 and a pharmaceutically acceptable carrier.
- 15. A method of delivering the antibiotic product of claim 1 to a patient comprising the step of orally administering an antibiotically effective amount of said antibiotic product to said patient.
- 16. An isolated Group A PIIF streptogramin of the formula (II): ##STR14##
- 17. An isolated Group A PIIG streptogramin of the formula (II): ##STR15##
- 18. A Group A PIIB streptogramin of the formula (II): ##STR16## said streptogramin being at least 92% pure by weight.
- 19. A Group A PIIB streptogramin of the formula (II) according to claim 18, wherein said streptogramin is at least 94% pure by weight.
- 20. A Group A PIIB streptogramin of the formula (II) according to claim 19, wherein said streptogramin is at least 97% pure by weight.
- 21. An antibiotic product comprising streptogramins selected from the group consisting of
- at least one Group B streptogramin of the formula (I) and
- at least one Group A streptogramin of the formula (II),
- wherein the total amount of streptogramin impurities is less than 6% of said product, and
- wherein said streptogramin impurities are streptogramins other than those of formulae (I) and (II),
- wherein said at least one Group B streptogramin of the formula (I) has the formula: ##STR17## wherein (1) A.sub.1 is a radical of the formula (Ia) or (Ia') ##STR18## wherein R' is a hydrogen atom or a hydroxyl radical, and Y is a hydrogen atom, a methylamino radical or a dimethylamino radical, and R is an ethyl radical, or when R' represents a hydrogen atom, R can also represent a methyl radical, and R.sub.1 and R.sub.2 each represent a hydrogen atom, or
- (2) A.sub.1 is a radical of formula (Ib): ##STR19## wherein R is an isobutyl radical, and R.sub.1 is a hydroxyl radical and R.sub.2 is a methyl radical;
- wherein said at least one Group A streptogramin of the formula (II) has the formula: ##STR20## wherein R" is a hydrogen atom, a methyl radical or an ethyl radical.
- 22. An antibiotic product according to claim 21, wherein said streptogramin impurities include PIIA.
Priority Claims (1)
Number |
Date |
Country |
Kind |
93 01787 |
Feb 1993 |
FRX |
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Parent Case Info
This is a continuation of application Ser. No. 08/197,984, filed on Feb. 17, 1994 now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4618599 |
Corbet et al. |
Oct 1986 |
|
4668669 |
Barriere et al. |
May 1987 |
|
4798827 |
Barriere et al. |
Jan 1989 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2 619 008 |
Feb 1989 |
FRX |
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts, vol. 110, No. 7, Feb. 13, 1989, Columbus Ohio, abstract No. 56082, N.K. Sharma et al. |
Continuations (1)
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Number |
Date |
Country |
Parent |
197984 |
Feb 1994 |
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