Claims
- 1. A compound of the formula ##STR12## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);
- R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);
- R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;
- n and m are each independently 0, 1 or 2, the sum of n and m being 2;
- X, Y and Z are each independently --NR.sub.4 -- or .dbd.CR.sub.5 --, provided that only one of X, Y and Z is --NR.sub.4 --;
- R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms; and
- R.sub.5 is hydrogen;
- or, when m and n are both 1, the dihydro form with its double bond in conjugation with the C-terminal carboxylic group;
- or a non-toxic, pharmacologically acceptable salt thereof.
- 2. A compound of claim 1, where all of the centers of asymmetry are in the L-configuration.
- 3. An antihypertensive pharmaceutical composition consisting essentially of an inert pharmaceutical carrier and an effective antihypertensive amount of a compound of claim 1.
- 4. The method of lowering the blood pressure of a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective antihypertensive amount of a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3302125 |
Jan 1983 |
DEX |
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Parent Case Info
This is a division of Ser. No. 749,473, filed June 27, 1985, now U.S. Pat. No. 4,683,238 which in turn is a division of Ser. No. 572,179, filed Jan. 19, 1984, now U.S. Pat. No. 4,555,511.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4683238 |
Schnorrenberg et al. |
Jul 1987 |
|
Divisions (2)
|
Number |
Date |
Country |
Parent |
749473 |
Jun 1985 |
|
Parent |
572179 |
Jan 1984 |
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