Rapidly dissolving solid oral dosage form for delivery of composition for increasing nitric oxide activity

Abstract

The present invention relates to a dietary supplement and method for a rapidly dissolving and disintegrating solid oral dosage form. Specifically, the present invention provides dietary supplements and methods for the delivery of dietary supplements comprising Arginine or derivatives thereof and Xanthinol Nicotinate or derivatives thereof. By way of oral administration to an individual of said solid oral dosage form, a method of rapidly increasing nitric oxide activity in an individual is also provided.

Description

Claims

1. A dietary supplement comprising Arginine or derivatives thereof and Xanthinol Nicotinate or derivatives thereof.

2. The dietary supplement of claim 1, further comprising Crospovidone or derivatives thereof.

3. The dietary supplement of claim, 1 further comprising Croscarmellose or derivatives thereof.

4. A composition of claim 1, wherein the Arginine or derivatives thereof are fine-milled.

5. A composition of claim 1, wherein at least from about 1% to about 10% of the Arginine or derivatives thereof are fine-milled.

6. A composition of claim 5, wherein the Arginine or derivatives thereof are fine-milled between 2 nm and 50 nm in average particle size.

7. A method of decreasing the disintegration time of tablet comprising at least Arginine or derivatives thereof as an active ingredient.

8. The method of claim 7 wherein hydrophilic Croscarmellose or derivatives thereof are used as a tablet disintegrant.

9. The method of claim 8 wherein said hydrophilic Croscarmellose absorbs a liquid and swells resulting in the promotion of the dissolution and disintegration of a tablet.

10. The method of claim 8 wherein said Crocarmellose is imbedded in and in communication with the constituents of a tablet wherein the exploitation the hydrophilic properties of Croscarmellose results in a rapid dissolution and disintegration of said tablet.

11. The method of claim 10 wherein the time to bioavailability of said active ingredients is decreased.

12. The method of claim 7 wherein hydrophilic Crosprovidone or derivatives thereof are used as a tablet disintegrant.

13. The method of claim 12 wherein said hydrophilic Crospovidone absorbs liquids and swells resulting in the promotion of the dissolution and disintegration of a tablet.

14. The method of claim 12 wherein said Crospovidone is imbedded in and in communication with the constituents of a table wherein the exploitation the hydrophilic properties of Croscarmellose results in a rapid dissolution and disintegration of said tablet.

15. The method of claim 14 wherein the time to bioavailability of said active ingredients is decreased.

16. A method comprising the step of the administering to an individual, e.g. a human or an animal comprising a dietary supplement according to claim 1.

17. A method comprising the step of the administering to an individual, e.g. a human or an animal comprising a dietary supplement according to claim 2.

18. A method comprising the step of the administering to an individual, e.g. a human or an animal comprising a dietary supplement according to claim 3.

19. A method comprising the step of the administering to an individual, e.g. a human or an animal comprising according a dietary supplement to claim 2 wherein said Croscarmellose decreases the dissolution and disintegration time when said dietary supplement is administered in the form of a tablet.

20. A method comprising the step of the administering to an individual, e.g. a human or an animal comprising according a dietary supplement to claim 3 wherein said Crospovidone decreases the dissolution and disintegration time when said dietary supplement is administered in the form of a tablet.