Claims
- 1. A combination of a matrix with memory, comprising:
- (A) a recording device, comprising a data storage unit programmed with information that identifies a molecule or biological particle that is proximate to the matrix;
- (B) a matrix material, and
- (C) the molecule, biological particle, mixture of molecules, mixture of biological particles or a mixture of molecules and biological particles in proximity to the matrix, wherein:
- the device is less than about 5 mm.sup.3 in size;
- the matrix material is in the form of a container used for chemical syntheses;
- the recording device is in contact with the matrix or in a composition that is in contact with the matrix;
- the molecules are either linked to the matrix or in a composition that is in contact with the matrix and comprise nucleic acids, oligonucleotides, nucleotides, amino acids, biopolymers, organic molecules, peptides or proteins;
- the biological particles are either linked to the matrix or in a composition that is in contact with the matrix and comprise viral capsids with or without packaged nucleic acids, phage, phage capsids with or without encapsulated nucleotide acid, eukaryotic cells, prokaryotic cells or fragments thereof; and
- the data storage unit is electromagnetically remotely programmable.
- 2. The combination of claim 1, wherein the recording device comprises:
- a memory device having a non-volatile memory means for storing a plurality of data points and means for receiving a transmitted write signal so that the write signal causes a stored data point corresponding to the data signal to be stored within the non-volatile memory means.
- 3. The combination of claim 1, wherein the recording device further comprises an antenna for receiving transmitted electromagnetic radiation.
- 4. The combination of claim 1, wherein the recording device is encased in the matrix material.
- 5. The combination of claim 1, wherein:
- the memory device comprises an optical recording medium having a plurality of unique recording locations therein; and
- each of plurality of unique recording locations is uniquely addressable for storing the plurality of data points.
- 6. The combination of claim 5, wherein the memory device comprises a shell for enclosing the optical recording medium, the shell comprising a material that is inert with respect to the optical recording medium, and is transmissive of an optical signal.
- 7. The combination of claim 5, wherein the each of the plurality of unique recording locations comprises a spectral hole corresponding to a unique wavelength of light.
- 8. The combination of claim 1, wherein at least one surface of the device is coated with the matrix material.
- 9. The combination of claim 1, wherein the matrix material is continuous and is in the form of a container, which contains one or more recording device(s) impregnated in the matrix or inside the container, wherein the container is transmissive of at least a portion the electromagnetic spectrum, and the portion includes at least visible light, infrared light, radio frequencies, ultraviolet light or other light.
- 10. The combination of claim 3, wherein the container is a microtiter plate with a plurality of wells, in which on or more of the wells contain the recording device, or is a test tube, culture dish, vial or beaker.
- 11. The combination of claim 1, wherein the matrix material is selected from among a polystyrene, a cellulose, a glass, a polyacrylamide, a polysaccharide, a rubber, silicon, a plastic, sand, pumice, agarose, halogenated hydrocarbon polymers, and any polymer used as a matrix in solid phase syntheses.
- 12. The combination of claim 1, wherein:
- the matrix particles are in the form of a container;
- the container is less than about 50 ml in volume or comprises a plurality of wells, each being about 1 ml or less in volume;
- the container is transmissive to electromagnetic radiation selected from radio frequencies, infrared wavelengths, ultraviolet wavelengths, microwave frequencies, visible wavelengths or laser light;
- the recording device comprises a memory device having a non-volatile memory means for storing a plurality of data points and means for receiving the transmitted signal so that the write signal causes a stored data point corresponding to the data signal to be stored within the non-volatile memory means;
- the recording device is about 5 mm.sup.3 in size or less;
- the recording device is remotely programmable using electromagnetic radiation;
- the recording device is in contact with the container; and
- the molecules and/or biological particles are in a composition in the container.
- 13. The combination of claim 12, wherein the container is comprised of a polymeric material to which molecules or biological molecules can be bound.
- 14. The combination of claim 12, wherein the container is a well of a microtiter plate.
- 15. The combination of claim 12, wherein the container is a vial or test tube.
- 16. A matrix particle, comprising:
- a recording device in contact with the particle;
- the matrix particle is less than about 10 mm.sup.3 in size, and is comprised of a polymeric material adapted for binding molecules or biological particles;
- the recording device comprises a memory device having memory means for storing a plurality of data points and means for receiving the transmitted signal so that the write signal causes a stored data point corresponding to the data signal to be stored within the non-volatile memory means;
- the recording device is encased in the matrix;
- the recording device is about 5 mm.sup.3 in size or less;
- the recording device is remotely programmable using electromagnetic radiation; and
- biological particles and/or molecules are linked to the surface of the matrix.
- 17. A library, comprised of a plurality of the combinations of claim 16.
- 18. The library of claim 17 that is a combinatorial library.
- 19. The library of claim 16, wherein the components of the library are molecules that are peptides, oligonucleotides, peptoids or organic molecules.
- 20. The library of claim 19 that is a phage display library.
RELATED APPLICATIONS
This application is a continuation-in-part of U.S. application Ser. No. 08/428,662, filed Apr. 25, 1995, by Michael P. Nova and Andrew E. Senyei, entitled, "REMOTELY PROGRAMMABLE MATRICES WITH MEMORIES". The subject matter of U.S. application Ser. No. 08/428,662 is herein incorporated by reference in its entirety. The subject matter of copending application entitled "REMOTELY PROGRAMMABLE MATRICES WITH MEMORIES" filed on the same day as this application, and having U.S. application Ser. No. 08/480,196, by Michael P. Nova, Andrew E. Senyei and Gary S. David is also incorporated herein by reference thereto.
US Referenced Citations (265)
Foreign Referenced Citations (32)
Number |
Date |
Country |
0196174 |
Oct 1986 |
EPX |
0420177 |
Apr 1991 |
EPX |
0526173 A2 |
Feb 1993 |
EPX |
0526173 A3 |
Feb 1993 |
EPX |
0535242 |
Apr 1993 |
EPX |
0541340 |
May 1993 |
EPX |
0637750 |
Feb 1995 |
EPX |
2526169 |
Apr 1983 |
FRX |
2555744 |
May 1985 |
FRX |
4310169 |
Sep 1993 |
DEX |
4213065 |
Oct 1993 |
DEX |
4313807 |
Nov 1993 |
DEX |
4301401 |
Jul 1994 |
DEX |
4306563 |
Sep 1994 |
DEX |
9416270 |
Dec 1994 |
DEX |
57-016359 |
Jan 1982 |
JPX |
8603840 |
Jul 1986 |
WOX |
8901157 |
Feb 1989 |
WOX |
8908264 |
Sep 1989 |
WOX |
9015070 |
Dec 1990 |
WOX |
9201268 |
Jan 1992 |
WOX |
9210092 |
Jun 1992 |
WOX |
9209300 |
Jun 1992 |
WOX |
9306121 |
Apr 1993 |
WOX |
9308472 |
Apr 1993 |
WOX |
9413402 |
Jan 1994 |
WOX |
9402634 |
Feb 1994 |
WOX |
9405394 |
Mar 1994 |
WOX |
9408051 |
Apr 1994 |
WOX |
9411388 |
May 1994 |
WOX |
9413623 |
Jun 1994 |
WOX |
9414980 |
Jul 1994 |
WOX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
428662 |
Apr 1995 |
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