General methods for the preparation of peptides

CCHEMISTRY METALLURGY C07Organic chemistry C07KPEPTIDES

C07K1/00General methods for the preparation of peptides

C07K1/003by transforming the C-terminal amino acid to amides C07K1/006of peptides containing derivatised side chain amino acids C07K1/02in solution C07K1/023using racemisation inhibiting agents C07K1/026by fragment condensation in solution C07K1/04on carriers C07K1/042characterised by the nature of the carrier C07K1/045using devices to improve synthesis C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries C07K1/06using protecting groups or activating agents C07K1/061using protecting groups C07K1/062for alpha- or omega-carboxy functions C07K1/063for alpha-amino functions C07K1/064for omega-amino or -guanidino functions C07K1/065for hydroxy functions, not being part of carboxy functions C07K1/066for omega-amido functions C07K1/067for sulfur-containing functions C07K1/068for heterocyclic side chains C07K1/08using activating agents C07K1/082containing phosphorus C07K1/084containing nitrogen C07K1/086containing sulfur C07K1/088containing other elements C07K1/10using coupling agents C07K1/107by chemical modification of precursor peptides C07K1/1072by covalent attachment of residues or functional groups C07K1/1075by covalent attachment of amino acids or peptide residues C07K1/1077by covalent attachment of residues other than amino acids or peptide residues C07K1/113without change of the primary structure C07K1/1133by redox-reactions involving cystein/cystin side chains C07K1/1136by reversible modification of the secondary, tertiary or quarternary structure C07K1/12by hydrolysis C07K1/122Hydrolysis with acids different from HF C07K1/124Hydrazinolysis C07K1/126Aminolysis C07K1/128sequencing C07K1/13Labelling of peptides C07K1/14Extraction Separation Purification C07K1/145by extraction or solubilisation C07K1/16by chromatography C07K1/165mixed-mode chromatography C07K1/18Ion-exchange chromatography C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography C07K1/22Affinity chromatography or related techniques based upon selective absorption processes C07K1/24by electrochemical means C07K1/26Electrophoresis C07K1/28Isoelectric focusing C07K1/285multi dimensional electrophoresis C07K1/30by precipitation C07K1/303by salting out C07K1/306by crystallization C07K1/32as complexes C07K1/34by filtration, ultrafiltration or reverse osmosis C07K1/36by a combination of two or more processes of different types