The present invention relates to a sample transport system suitable for a clinical laboratory automation system that handles vessels such as sample tubes containing a specimen and more particularly to a sample transport system that efficiently utilizes a sample transport path using transport units movable two-dimensionally in a plane.
As one example of the method for operating a research laboratory sample distribution system, Patent Literature 1 describes a research laboratory sample distribution system in which a sample vessel carrier holds one or more sample vessels, the sample vessel contains the sample to be analyzed by a specified number of research laboratory stations, a transport surface is provided and structured to support the sample vessel carrier, a specified number of transport positions are arranged on the transport surface and the transport positions are assigned to the corresponding research laboratory stations.
Patent Literature 1: Japanese Patent Application Laid-Open No. 2016-218060
In clinical inspection, an automatic analyzer that includes modules for performing pre-anlytical processes such as centrifugation, uncapping and dispensing for a sample tube containing a biological sample collected from a human body such as blood or urine (hereinafter referred to as a specimen) has the function to mount the sample tube containing the specimen on a carrier such as a rack or holder in order to perform various processes sequentially and transport it to the relevant processing sections.
On a transport path to transport these, generally the carrier is moved in forward and backward directions one-dimensionally so that the carrier is transported physically with stability.
Therefore, vessels that contain various specimens, including not only a normal sample to be processed in a normal time period, but also a STAT sample from an emergent treatment room or operating room, a sample under processing for which other various processes have been finished and a processed sample, are transported on a one-dimensional transport path.
In this kind of system, in order to handle an STAT sample, usually a transport path for STAT samples is provided apart from a line for normal samples. In addition, by providing a transport path to connect the transport of a normal sample and that of a STAT sample at a specific spot, the STAT sample can overtake the normal sample so that the STAT sample can be preferentially processed and transported. Furthermore, two or more one-dimensional paths may be combined so that the normal sample stands by temporarily.
On the other hand, unlike a one-dimensional transport path which is physically fixed, a transport unit that enables two-dimensional movement in a plane has a feature that a transport path can be logically made on the transport surface forming the upper surface of the transport unit.
The technique described in Patent Literature 1 is one aspect of this technique. In this technique, electromagnetic coils are installed on the lower surface of the transport surface and an electric current is supplied to these electromagnetic coils successively to move the holder with a magnet that is placed on the transport surface.
Here, in order to transport along each position on a transport path in one vertical or horizontal direction, it is necessary to check whether or not another holder is present on the positions that constitute the transport path. For this reason, the transport unit incorporates a sensor and has a memory area that stores its condition at the same time.
In a sample transport system that adopts a sample transport path using a transport surface to enable planar two-dimensional movement instead of a transport path system as a combination of one-dimensional transport paths, like the one in Patent Literature 1, a management section that manages the whole system including all the transport surfaces makes a concrete transport path.
In this case, there is a problem that when the system is larger, the management section must handle a larger amount of information and the total amount of information including the route definition information required to determine a transport path and holder position information is larger, resulting in a larger load on the communication system. Even if the system is small, there is also a problem that a burden is put on the management section itself.
Therefore, there is a demand for an information holding method that reduces the amount of information including the route definition information required to determine a transport path and the holder position information and does not put a burden on the communication system.
The object of the present invention is to provide a sample transport system that reduces the load on the communication system as compared with the prior art.
The present invention includes a plurality of means to solve the above problem and one example is a sample transport system for transporting carriers equipped with sample tubes in which specimens are contained, which comprises: a plurality of transport units capable of moving the carriers in a two-dimensional direction in a plane; a plurality of control sections for managing action of the transport units; a control driver provided for each of the transport units to perform driving and situation detection of the transport unit; and a management section for integrally managing the sample transport system. The sample transport system is configurated to combine a plurality of the transport units and to be connectable to a preprocessing module for performing preprocessing before analysis for the specimens, a postprocessing module for performing postprocessing for the specimens, or an analysis module for performing analysis of the specimens. The control section is connected between the management section and a plurality of the control drivers. The management section generates transport route information on a destination of the carriers, based on a situation of the transport units that has been detected by the control drivers. The control section generates a transport route of the carriers in the transport units managed by the control driver connected based on the transport route information and generates a command signal to the transport units to output the command signal to the control driver.
According to the present invention, the load on the communication system can be reduced as compared with the prior art. Other issues, elements and effects will become apparent from the description of embodiments given below.
Next, a sample transport system according to embodiments of the present invention will be described referring to drawings.
A sample transport system according to the first embodiment of the present invention will be described referring to
First, the whole automatic analysis system including the sample transport system will be described referring to
The sample transport system 100 shown in
The sample transport system 100 shown in
In the sample transport system 100, a plurality of transport tiles 401 movable two-dimensionally in a plane make connection between the preprocessing modules 601 and 602 and between these modules and a plurality of automatic analysis modules 603, 604, 605, and 606.
Consequently, the sample tube 31 put in from the preprocessing module 601 having the sample input unit is transported to the prescribed preprocessing module 602 thorough the transport tiles 401 and then transported to the automatic analysis modules 603, 604, 605, and 606 through the transport tiles 401.
In order to transport the sample tube 31 containing a specimen, the sample transport system 100 includes a plurality of carriers. The carriers each have a magnetic body such as a permanent magnet on their bottom side, namely on their transport tile 401 side surface and each carrier is structured to hold one or more sample tubes 31.
The transport tiles 401 have a tile-like shape and are positioned two-dimensionally in a plane so that a plurality of holders 30 can stand by. The transport tiles 401 are structured so that the whole sample transport system 100 makes a flat plane to support and transport the holder 30.
One transport tile 401 includes: an electromagnetic coil 402 comprised of a core and a winding around the core; a drive circuit for supplying an electric current to the electromagnetic coil 402; and a sensor for detecting whether or not there is a holder just above it, and includes a plurality of these coils, drive circuits and sensors.
Usually, the transport tiles 401 have a transport surface (not shown) to support the holder 30 between the electromagnetic coils 402 and the holder 30. As the electromagnetic coils 402 under the transport surface are successively electrified, the holder 30 with a magnetic body that is placed on the transport surface moves in a sliding manner.
Details of the sensor for detecting the holder 30 are not limited. For example, it may be a Hall sensor that detects the magnetic flux of the magnetic body attached to the bottom of the holder 30, or a length measuring device or camera. Furthermore, another method may be used.
The management section 101 controls operation of the whole sample transport system including the sample transport system 100, preprocessing modules 601 and 602 and automatic analysis modules 603, 604, 605, and 606. It is a computer that includes a display device such as a liquid crystal display, an input device, a storage unit, a CPU, and a memory.
The management section 101 also controls various actions of the above modules and so on.
The various devices are controlled by the management section 101 according to the various programs stored in the storage unit.
Processing for operation control by the management section 101 may be performed according to a single program or a plurality of programs or a combination of programs. Part or all of a program may be implemented by dedicated hardware or in the form of a module.
Although
Details of the preprocessing module structure are also not limited and a known preprocessing device structure may be adopted. If two ore more preprocessing modules are provided, they may have the same specification or different specifications and their specifications are not limited.
The same is true for the automatic analysis modules. A known automatic analyzer that performs analysis for biochemical items and immunological items may be adopted. If two or more automatic analyzers are provided, they may have the same specification or different specifications and their specifications are not limited.
Here, destination information is required for the holder 30 to move on a transport tile 401 or between transport tiles 401. Next, the configuration of the sample transport system to generate destination information will be explained referring to
First, the system configuration will be explained referring to
As shown in
In this embodiment, as shown in
Furthermore, each of the control sections 201, 202, and 203 in this embodiment is connected to a plurality of transport tiles 401 and controls the transport tiles 401. For example, as shown in
For example, the maximum number of control drivers that can be connected to one control section 201, namely the total number of transport tiles 401, is 64. However, in configuring the system, the number may be varied depending on the CPU performance, system price, processing speed and other factors.
For the convenience of illustration,
Furthermore, in this embodiment, as shown in
The management section 101 can know which spot is congested in the sample transport system 100, by referring to the sample situation memory 2. After that, the management section 101 can define (generate) route definition information 1 for the holder 30 in consideration of the congested spot known from the sample situation memory 2. The management section 101 outputs the defined transport route information to the control sections 201, 202, and 203.
The control sections 201, 202, and 203, which have received the transport route information, calculate which positions (route) to be used by the holder 30, in consideration of the situation in the transport tiles 401 in the area under their control and give an instruction to the relevant control drivers 301, 302, 303, and 304 to transport the holder 30.
Each of the control sections 201, 202, and 203 manages a plurality of corresponding transport tiles 401. It is desirable to notify the management section 101 of the situation of all the transport tiles 401 under the control by the control sections 201, 202, and 203, for example, in cycles of 3 seconds, rather than notifying the management section 101 of the situation each time the situation of one position on the transport tiles 401 has changed.
The sample situation memory 2 exists on the storage unit, such as a memory or hard disk drive, in the management section 101. As shown in
For example, “0×0” can mean that the holder 30 is absent; “0×1” can mean that the holder 30 is present above it; “0×5” can mean that processing by the adjacent preprocessing module or analysis module is in progress; “0×8” can mean an error (holder 30 is absent); and “0×9” can mean an error (holder 30 is present).
Here, if the control section 20 controls twenty transport tiles 401, the data indicating the situation of the transport tiles 401 that is exchanged between the control section 201 and the management section 101 is telegram data, the amount of which is as follows:
20 transport tiles×18 bytes=360 bytes
The amount of this telegram data is not more than one half that of cleartext data as a communication text.
The update cycle of the sample situation memory 2 is determined depending on the processing speed of the sample transport system 100. Specifically, if the transport capability is 1,200 carriers/hour, the update cycle of 3 seconds is enough because 3,600 seconds+1,200 carriers=3 seconds. However, if the transport capability is 1,800 carriers/hour, updating in cycles of 2 seconds is needed. Therefore, it is desirable that the cycle of the control section 201 notifying the management section 101 of the sample situation should be variable.
Each of the control sections 201, 202, and 203 refers to the route definition information 1 at startup or at the time of resetting and determines the purpose of use of each transport tile 401. The transport definition information of one position is expressed by one byte (route definition information of one position 12) and as indicated by meaning 14 of one definition column 13 of route information definition, definitions are made with respect to the buffer, processing sections, direction, speed, and whether to limit or not in the vertical and transverse directions.
For example, as shown in
In addition, for the transport tiles to enable two-dimensional transport, in order to define intersection of transport paths and moving directions in a buffer area, not only E direction in the meaning 14 of definition column of route information definition, but also F and G (whether to limit or not in vertical and transverse directions) in the meaning 14 of definition column of route information definition can be specified.
Furthermore, H in the meaning 14 of definition column of route information definition can be used for definition to enable transport at high or low speed by changing the electric current to electrify the electromagnetic coils 402 in the electromagnetic method.
The transport path 17 shown in
On the other hand, the transport path 15 transports the holder 30 at low speed leftward in
In addition, the transport paths 15, 16, and 17 can transport it only in the transverse direction.
Next,
The transport tiles 411 to 426 in
The transport route area 501 represents a transport path for forward transport from left to right in
The buffer definition area 502 is located in the center of
The processing section definition area 504 is an area which functions as an interface with the analysis module 607 in the right bottom of
Next, the effects of this embodiment will be explained.
In the above sample transport system 100 according to the first embodiment of the present invention, the management section 101 generates transport route information to transport the holder 30 on the basis of the situation of transport tiles 401 that has been detected by the control drivers 301, 302, 303, and 304, and the control sections 201, 202, and 203 generate a transport route of the holder 30 on the basis of the transport route information, generates a command signal to the transport tiles 401 and outputs it to the control drivers 301, 302, 303, and 304.
Consequently, the information exchanged between the management section 101 and the control sections 201, 202, and 203 for controlling a plurality of transport tiles 401 is not concrete transport route information for the holder 30 but merely rough information concerning the destination. This makes the load on the communication system smaller than before, so high transport efficiency can be achieved. In addition, the following advantageous effects are produced: the management section 101, responsible for integrated management, need not generate concrete route information and thus the load on the management section 101 itself can be smaller than before, thereby suppressing the need for higher performance of the management section 101.
In addition, since the update cycle of the situation of the holder 30 that is managed by the management section 101 is determined depending on the transport capability of the sample transport system 100, the position information of the holder 30 is prevented from being exchanged each time the holder 30 moves and thus the updating frequency can be decreased as compared with the prior art. Therefore, the load on the communication system can be reduced.
Furthermore, the transport route information includes not only route information to carry in, or out of, at least one of the preprocessing modules 601 and 602 and automatic analysis modules 603, 604, 605, and 606, but also route information for low speed or stop to perform processing of the sample tube 31 by at least one of the preprocessing modules 601 and 602 and automatic analysis modules 603, 604, 605, and 606, so a variety of transport situations for the holder 30 can be produced and thus more flexible transport can be realized by the whole system.
The sample transport system according to the second embodiment of the present invention will be described. The same elements as in the first embodiment are designated by the same reference signs and their description is omitted. The same is true for the embodiments described below.
For the sample that has been put into the above sample transport system 100, the transport route to the required preprocessing modules 601 and 602 and the transport route to the automatic analysis modules 603, 604, 605, and 606 are determined according to the inspection item for which measurement should be made, namely the requested inspection item.
In connection with the transport route information generated by the management section 101, when the scale of the sample transport system 100 is larger, the number of the automatic analysis modules 603, 604, 605, and 606 to operate asynchronously is larger, which might cause unexpected congestion to occur partially.
In addition, when the scale of the sample transport system 100 is larger, even in the system in which the management section 101 checks the situation of all the transport tiles 401 to generate a route, the burden on the management section 101 would tend to increase and reduction in the load would be needed.
Therefore, in determining the transport route, it is desirable, for example, that the management section 101 should determine the degree of congestion of holders 30 on the basis of the congestion condition of transport tiles 401 that has been detected by the control drivers 301, 302, 303, and 304 and recorded in the sample situation memory 2 and correct the transport route so as to achieve the shortest time.
For example, if, as the default route definition as shown in
Therefore, if the management section 101 judges that many specimens must be measured by the analysis module 607, it can change the transport route definition to a definition that, in the transport tiles 426, 425, and 424 to be connected to the analysis module 607, five rows are in the forward direction and one row is used in the backward direction so that the congestion before the analysis module 607 is alleviated.
In addition, if, in the sample transport system 100, a plurality of modules of identical specification configuration exist among the preprocessing modules 601 and 602 and the automatic analysis modules 603, 604, 605, and 606, it is desirable for the management section 101 to indicate the transport route information by treating the modules not as individual modules but as a module group as a group of modules of identical specification, instead of indicating the positions on the transport tiles 401.
For example, the destination information may include a preprocessing module group as a group of identical processing modules, in addition to or instead of preprocessing modules required for processing. Also, the destination information may include an analysis module or an analysis module group as a plurality of analysis modules that can make measurements for the same inspection.
The control sections 201, 202, and 203, which have received the destination information based on such group management, calculates which positions are used to make a route for the holder 30, in consideration of the situation in the transport tiles 401 that are managed by the control sections 201, 202, and 203, and send a command to the relevant control drivers 301, 302, 303, and 304.
When the control sections 201, 202, and 203 calculate a route, they refer to the route information in
The other elements and actions are almost the same as in the first embodiment and details thereof are omitted.
The sample transport system according to the second embodiment of the present invention also produces almost the same advantageous effects as the above sample transport system according to the first embodiment.
In addition, the management section 101 can change the route in order to resolve the bottlenecks for a STAT sample's overtaking or avoidance of congested spots that a one-dimensional transport path could not solve, by correcting the transport route information according to the congestion situation of transport tiles 401 that has been detected by the control drivers 301, 302, 303, and 304. Thus, the transport efficiency of the sample transport system 100 can be further improved.
Furthermore, if, among the preprocessing modules 601 and 602 and automatic analysis modules 603, 604, 605, and 606, at least some of them area a plurality of modules of identical specification configuration, the management section 101 treats them not as individual modules but as a module group as a group of modules of identical specification and thereby reduces the amount of data exchanged between the management section 101 and the control sections 201, 202, and 203 for transport route information, so the advantageous effect that the load can be reduced even if the scale of the system is larger can be
The sample transport system according to the third embodiment of the present invention will be described referring to
Basically, the route definition information 1 is changed before the sample transport system 100 is operated, such as at the startup of the management section 101 or at the time of resetting.
However, the specimen analysis result can be obtained more quickly by changing the destination or transport route for the holders 30 according to the congestion situation of holders 30 in the sample transport system 100 or the progress of processing by the preprocessing module 601 or 602 or the automatic analysis module 603, 604, 605 or 606.
In order to cope with such a case, the management section 101 in the sample transport system 100 according to this embodiment corrects the transport route information on the basis of the congestion situation of transport tiles 401 that has been detected by the control drivers 301, 302, 303, and 304.
Then, when the transport route information is corrected by the management section 101, the control sections 201, 202, and 203 maintain the transport route before correction if holders 30 exist on the route before correction, and correct the transport route after transport of all the holders 30 is finished. Next, the method for correction will be explained in detail referring to
It is supposed that the management section 101 refers to the sample situation memory 2 that is periodically updated during operation and decides whether it is necessary to change the route definition or not. It is desirable to make this decision on the basis of the congestion situation of holders 30 in the sample transport system 100 or the progress of processing by the preprocessing module 601 or 602 or the automatic analysis module 603, 604, 605 or 606, as mentioned above.
If it is decided that it is necessary to change the route definition, the management section 101 changes the route definition and outputs the changed route definition to the control sections 201, 202, and 203. On the other hand, if it is decided that it is unnecessary to change the route definition, the management section 101 maintains the existing route information and outputs the route definition to the control sections 201, 202, and 203.
After start of operation (Step S701), the control sections 201, 202, and 203 decide whether the route definition currently in use has been changed or not (Step S702). If the control sections 201, 202, and 203 decide that the route definition has been changed, they make the process go to Step S703 or if they decide that the route definition has not been changed, they make the process go to Step S707.
If it is decided that the route definition currently in use has been changed, the control sections 201, 202, and 203 first decide whether or not there is a holder 30 being transported based on the previous transport definition, on the transport tiles 401 managed by the control sections 201, 202, and 203 respectively (Step S703). If it is decided that there is a holder 30, they make the process go to Step S704. On the other hand, if it is decided that there is no holder 30, they make the process go to Step S706.
If it is decided at Step 703 that there is a holder, the control sections 201, 202, and 203 lock the current transport route (Step S704) and continue transporting the holder 30 (Step S705). After that, they make the process go back to Step S703 to finish the transport of the holder 30 based on the previous route definition. At this time, it is desirable to perform preferential control to prevent a new holder 30 from being carried onto a position whose purpose of use is changed after definition change.
On the other hand, if it is decided at Step S703 that there is no holder 30, the control sections 201, 202, and 203 change the transport definition (Step S706) because there is no holder 30 on the changed route and starts transport control of a holder 30 along the transport route according to the new transport definition.
If it is decided at Step S702 that the route definition has not been changed, the control sections 201, 202, and 203 lock the current transport route (Step S707) in the same way as at Steps S704 and S705 and continue transporting the holder 30 (Step S708).
After that, the process is ended (Step S709).
The control sections 201, 202, and 203 refer to the route definition information 1 periodically during operation and carry out the above steps shown in
The other elements and actions are almost the same as in the sample transport system 100 according to the first embodiment and details thereof are omitted.
The sample transport system according to the third embodiment of the present invention also produces almost the same advantageous effects as the sample transport system 100 according to the first embodiment.
In addition, when the management section 101 has corrected the transport route information, the control sections 201, 202, and 203 maintain the transport route before correction if there is a holder 30 on the route before correction, and correct the transport route after transport of all holders 30 is finished, so that the route definition can be dynamically changed and the transport route can be flexibly controlled, for example, by changing the amount of transport in the downstream or upstream direction by time of day or changing the route for circumvention in case of an error. Thus, the transport efficiency can be further improved.
The present invention is not limited to the above embodiments but includes many variations. For example, the above embodiments have been described in detail for easy understanding of the present invention, but the present invention is not limited to a structure that includes all the elements described above.
Furthermore, an element of an embodiment may be replaced by an element of another embodiment or an element of an embodiment may be added to another embodiment. In each embodiment, addition of another element or deletion or replacement of an element can be made.
1: Route definition information
2: Sample situation memory
11: Route definition information of one transport tile
12: Route definition information of one position
13: One definition column of route information definition in one position
14: Meaning of definition column of route information definition
15, 16, 17: Transport path
21: Sample situation of one transport tile
22: Sample situation of two positions
30: Holder (Carrier)
31: Sample tube
100: Sample transport system
101: Management section
201, 202, 203: Control section
201A, 202A, 203A: Cover range
301, 302, 303, 304: Control driver
401: Transport tile (transport unit)
402: Electromagnetic coil
411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422,
423, 424, 425, 426: Transport tile
501, 503: Transport route area
502: Buffer definition area
504: Processing section definition area
601, 602: Preprocessing module
603, 604, 605, 606: Automatic analysis module
607: Analysis module
701, 702, 703, 704, 705, 706, 707, 708, 709: Processing flow at the time of changing route definition information
Number | Date | Country | Kind |
---|---|---|---|
2019-136004 | Jul 2019 | JP | national |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/JP2020/010627 | 3/11/2020 | WO |