Claims
- 1. An isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1; (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 30 to nucleotide 539; (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 99 to nucleotide 539; (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone BA3.1 deposited under accession number ATCC 98357; (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone BA3.1 deposited under accession number ATCC 98357; (f) a polynucleotide comprising the nucleotide sequence of the mature protein coding sequence of clone BA3.1 deposited under accession number ATCC 98357; (g) a polynucleotide encoding the mature protein encoded by the cDNA insert of clone BA3.1 deposited under accession number ATCC 98357; (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2; (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 80 to amino acid 89 of SEQ ID NO:2; (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; and (l) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(i).
- 2. The polynucleotide of claim 1 wherein said polynucleotide is operably linked to at least one expression control sequence.
- 3. A host cell transformed with the polynucleotide of claim 2.
- 4. The host cell of claim 3, wherein said cell is a mammalian cell.
- 5. A process for producing a protein encoded by the polynucleotide of claim 2, which process comprises:
(a) growing a culture of the host cell of claim 3 in a suitable culture medium; and (b) purifying said protein from the culture.
- 6. A protein produced according to the process of claim 5.
- 7. The protein of claim 6 comprising a mature protein.
- 8. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:2; (b) the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 140; (c) fragments of the amino acid sequence of SEQ ID NO:2 comprising the amino acid sequence from amino acid 80 to amino acid 89 of SEQ ID NO:2; and (d) the amino acid sequence encoded by the cDNA insert of clone BA3.1 deposited under accession number ATCC 98357; the protein being substantially free from other mammalian proteins.
- 9. The protein of claim 8, wherein said protein comprises the amino acid sequence of SEQ ID NO:2.
- 10. The protein of claim 8, wherein said protein comprises the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 140.
- 11. A composition comprising the protein of claim 8 and a pharmaceutically acceptable carrier.
- 12. A method for preventing, treating or ameliorating a medical condition which comprises administering to a mammalian subject a therapeutically effective amount of a composition of claim 11.
- 13. An isolated gene corresponding to the cDNA sequence of SEQ ID NO:1.
- 14. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO:1.
- 15. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 from nucleotide 30 to nucleotide 539.
- 16. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of the full-length protein coding sequence of clone BA3.1 deposited under accession number ATCC 98357.
- 17. The polynucleotide of claim 1, wherein the polynucleotide encodes the full-length protein encoded by the cDNA insert of done BA3.1 deposited under accession number ATCC 98357.
- 18. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of the mature protein coding sequence of BA3.1 deposited under accession number ATCC 98357.
- 19. The polynucleotide of claim 1, wherein the polynucleotide encodes the mature protein encoded by the cDNA insert of clone BA3.1 deposited under accession number ATCC 98357.
- 20. The polynucleotide of claim 1, wherein the polynucleotide encodes a protein comprising the amino acid sequence of SEQ ID NO:2.
- 21. The polynucleotide of claim 1, wherein the polynucleotide encodes a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 80 to amino acid 89 of SEQ ID NO:2.
- 22. The protein of claim 8, wherein the protein comprises a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 80 to amino acid 89 of SEQ ID NO:2.
- 23. The protein of claim 8, wherein the protein comprises the amino acid sequence encoded by the cDNA insert of clone BA3.1 deposited under accession number ATCC 98357.
- 24. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 from nucleotide 99 to nucleotide 539.
Parent Case Info
[0001] This application is a continuation-in-part of application Ser. No. 08/818,163, filed Mar. 14, 1997, which is incorporated by reference herein.
Continuations (1)
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Number |
Date |
Country |
Parent |
09041159 |
Mar 1998 |
US |
Child |
10041778 |
Jan 2002 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
08818163 |
Mar 1997 |
US |
Child |
09041159 |
Mar 1998 |
US |